Abstract: The invention relates to determining a representation of cardiac output in a patient. Provided are a method and a system for monitoring a cardiac output using a single device inserted into a Central Venous Catheter (CVC) or Peripheral Inserted Central Catheters (PICC) line. In an embodiment, the device contains an elongated body that fits the lumen of a Central Venous Cava or Peripheral Inserted Central Catheters line and has an ultrasound transducer at the tip. By operating the device such that the velocity in both the Superior Vena Cava and Inferior Vena Cava can be sampled continuously the CO is monitored.

Abstract: Systems, devices, and methods for automated, fast lung pulse detection are provided. In an embodiment, a system for detecting pneumothorax (PTX) includes an ultrasound probe in communication with a processor. The processor is configured to generate, using the ultrasound imaging data received from the ultrasound probe, an M-mode image including a pleural line of the lung. Using the M-mode image, the processor generates a difference image comprising a plurality of difference lines generated by subtracting adjacent samples of the M-mode image. The processor analyzes the difference image to determine whether the difference image includes a periodic signal corresponding to the heartbeat of the patient and outputs a graphical representation of detecting the lung pulse based on determining that the difference image includes the periodic signal corresponding to the heartbeat.

Abstract: A controller (310) for identifying positioning of an intravascular ultrasound probe (952) includes a memory (362) that stores instructions (884) and a processor (361) that executes the instructions (884). When executed by the processor (361), the instructions (884) cause the controller (310) to execute a process that includes receiving first signals from at least one element of the intravascular ultrasound probe (952). The process also includes receiving second signals from an external ultrasound probe. Based on the first signals and the second signals, the controller (310) determines a position of the intravascular ultrasound probe (952) in a tracking space that includes the intravascular ultrasound probe (952) and the external ultrasound probe.

Abstract: The invention provides a method for estimating the weight of a fetus. A plurality of different three dimensional ultrasound images of an imaging region are acquired, wherein the plurality of different three dimensional ultrasound images comprise: a head image; an abdominal image; and a femur image. Each of the plurality of different three dimensional ultrasound images undergoes segmentation and the fetal weight estimation is performed based on the resulting segmentations.

Abstract: An intraluminal imaging device includes a flexible elongate shaft including a distal portion and a proximal portion, wherein the flexible elongate shaft is configured for insertion into a patient body; a distal tip that comprises an imaging element and is operably associated with the distal portion of the flexible elongate shaft; and a control handle coupled to the proximal portion of the flexible elongate shaft, wherein the control handle includes: a first actuator configured to position the imaging element within the patient body; and a first frictional member coupled to the first actuator and arranged to contact the first actuator to control positioning of the imaging element. Associated devices, systems, and methods are also provided.

Abstract: An ultrasound probe positioning system (100) comprises a positioning unit (102) for holding an ultrasound probe unit (104) and for moving the ultrasound probe unit and positioning it at a target position and a positioning control unit (106) configured to provide target positioning data indicative of a target position that establishes a mechanical contact of the ultrasound probe unit with an external object (110) and to control the mechanical positioning unit in moving and positioning the ultrasound probe at the target position. The positioning unit comprises a force actuation unit (108) configured to adapt a pressing force amount of a mechanical pressing force exerted on the object in response to a variation of a counterforce amount so as to maintain a predetermined net pressing force amount exerted by the mechanical pressing force against the counterforce.

Abstract: An ultrasound system (1) has a configuration in which a mobile information terminal (3) is connected to an ultrasound probe (2) and a head-mounted display (4) in a wireless manner. The ultrasound probe (2) includes an image information data generation unit (19) that generates image information data. The mobile information terminal (3) includes a mobile information terminal-side display unit (34), an operation image generation unit (37) that generates an operation image for an input operation, and a head-mounted display data generation unit (36) that generates head-mounted display data from the image information data. The head-mounted display (4) displays a head-mounted display ultrasound image based on the head-mounted display data.

Abstract: According to one embodiment, an ultrasound diagnosis apparatus includes processing circuitry. The processing circuitry acquires a change in a display parameter related to image display in a first bloodstream imaging mode of displaying a bloodstream signal acquired by an ultrasonic probe during execution of the first bloodstream imaging mode, and determines whether or not the display parameter after the change is more suitable for a second bloodstream imaging mode than for the first bloodstream imaging mode, an imaging method of the second bloodstream imaging mode differing from an imaging method of the first bloodstream imaging mode.

Abstract: Provided is an ultrasound diagnostic apparatus to be applied to an ultrasound inspection of a living body part that moves with a movement of a subject in a living body inside the subject. The ultrasound diagnostic apparatus includes: an ultrasound image generation section that generates an ultrasound image based on a reception signal acquired from ultrasound probe which transmits and receives an ultrasound; an image analysis section that detects a movement of the subject by performing an image analysis of time-series camera images acquired from a camera which images the movement of the subject; and a display image generation section that generates a display image including the ultrasound image, and changes a display content or display mode of the display image in conjunction with the movement of the subject detected by the image analysis.

Abstract: The present disclosure provides an ultrasound probe, an ultrasound imaging apparatus, and a control method thereof that can efficiently and quickly determine whether a disinfectant remains in an ultrasound probe or whether the ultrasound is operating normally without changing the structure of an ultrasound imaging device. The ultrasound imaging apparatus of an embodiment includes: a display provided on the main body; a main body including at least one slot connected to the connector; and a controller configured to output a warning message to the display when the connector and the slot are connected and the current flowing from the ultrasound probe is out of a predetermined reference range, and the controller is composed of at least one processor included in the main body.

Abstract: The present invention relates to a saliva collection device. A saliva collection device according to one embodiment of the present invention comprises: a saliva collector part which is provided in a vessel shape open at one side thereof and has an inner collection space open at one side thereof; a saliva movement part having a predetermined length, connected at one end thereof to the saliva collector part, and provided in a pipe structure having a saliva movement passage connected to the collection space; and a saliva collection part connected to the other end of the saliva movement part and having an inner space in which saliva can be stored.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for extracting a tissue sample. In an illustrative embodiment, an apparatus includes a rotatable sampling element having a cylindrical body that defines a receiving chamber configured to receive therein a tissue sample cut from a tissue mass. A cutting apparatus is disposed at a distal end of the cylindrical body to cut the tissue sample from the tissue mass abutting the distal end responsive to rotation of the cylindrical body as it is pressed against the tissue mass. The apparatus also includes a flexible drive shaft having a distal end fixably engaged with a proximal end of the rotatable sampling element. The flexible drive shaft is linearly movable to motivate the rotatable sampling element to press it against the tissue mass and rotatable to impart rotational force to the rotatable sampling element to cause the rotatable sampling element to rotate around the axis.

Abstract: Systems, devices, and methods for performing tissue removal and analysis based on the in-situ optical analysis of tissue and liquid collected from a tissue region. A tissue removal and analysis probe involves an elongate tissue removal device, an optical fiber, and a fluid fillable conduit, wherein distal ends of the optical fiber and the conduit are in communication with an external region that is adjacent to a distal functional portion of the tissue removal device. The optical analysis results of at least one of external tissue and collected fluid is employed to determine whether tissue removal is to be performed. Various devices are interfaced with the conduit for optical analysis of the collected fluid. The tissue removal device is movable relative to the optical fiber and conduit.

Abstract: An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool.

Abstract: Disclosed are embodiments of a device for closing or occluding a cavity or opening within a body. Some embodiments of the device can include an implant configured to be deployed within the cavity, configured to be expanded or moved against a wall portion of the cavity, and configured to twist at least a portion of the cavity when the implant is rotated. Thereafter, a securing element, staple, suture, or other fastener can be implanted in the gathered tissue to hold the tissue in the gathered state, thereby occluding the opening of the cavity. The implant can remain in the cavity or be removed.

Abstract: A tissue specimen retrieval bag assembly includes a tissue specimen bag having an open proximal end including a cuff defined therein and extending around a periphery thereof, a closed distal end and a bag brim disposed within the cuff. The bag brim includes a cross section configured to facilitate furling the tissue specimen bag onto itself around the bag brim to approximate a tissue specimen contained within the bag for morcellation. The tissue specimen bag also includes a suture channel defined therein near the proximal end thereof. The suture channel is defined around the periphery of the tissue specimen bag and is configured to house a suture therein. Pulling the suture away from the tissue specimen bag cinches the tissue specimen bag to secure the tissue specimen therein.

Abstract: An elongate medical apparatus and a method for manufacturing the same. The apparatus including a base element and at least one spline. The base element and the at least one spline may include various materials to define various characteristics of the apparatus. For example, the base element may include a first material and define a lumen therein. The at least one spline may protrude from an outer surface of the base element and may include a second material. In one or more embodiments, the at least one spline may extend along a helical path.

Abstract: An elongate shaft and associated systems and methods are disclosed herein. In some embodiments, the elongate shaft comprises a lumen extending along a length of the elongate shaft, and a structure radially peripheral to the lumen. The structure can be tapered in a distal direction such that an outermost cross-sectional dimension at a proximal portion of the structure is greater than an outermost cross-sectional dimension at a distal portion of the structure. An innermost cross-sectional dimension of the structure can be generally constant along all or a portion of the length of the elongate shaft. In some embodiments, the structure can comprise a plurality of layers or regions.

Abstract: In one embodiment, the present invention relates to a tissue shaping device adapted to be disposed in a vessel near a patient's heart to reshape the patient's heart. Such tissue shaping device can include an expandable proximal anchor; a proximal anchor lock adapted to lock the proximal anchor in an expanded configuration; an expandable distal anchor; a distal anchor lock adapted to lock the distal anchor in an expanded configuration; and a connector disposed between the proximal anchor and the distal anchor, the connector having a substantially non-circular cross-section.

Abstract: Disclosed herein is an improved tissue retraction and direct visualization tool of a spinal surgical site, such as a site in the cervical spine, including a retractor assembly having a visualization channel, a first retractor member, and a second retractor member, the retractor assembly configured to be coupled to an actuator assembly configured to actuate the retractor assembly. In some aspects, the retractor assembly may transition from an unexpanded state for delivery to an expanded state for visualization. In some aspects, the retractor assembly is expanded with an actuator assembly. A method of using the visualization tool is also disclosed.

Abstract: Devices, systems, and methods for measuring a force applied to a joint during a surgical procedure are disclosed. The device includes an insertion tool, a handle, and one or more force indicators. The insertion tool includes an insertion end and a base end. The one or more force indicators may be attached to the insertion tool and the handle. The insertion end of the device may be inserted into a joint during a surgical procedure and used to apply a force to the joint and/or measure the force using the one or more force indicators when the force is applied.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for suturing a wound, incision, or other opening. In an illustrative embodiment, an apparatus includes a helically-shaped needle having a helical radius, the needle having a shaft and drawing a filament from a trailing end. Two generally-parallel rollers are configured to engage therebetween the shaft, the first roller having a roller radius that is less than the helical radius of the needle to enable the needle to revolve around the first roller to pierce a body adjacent the first roller and to draw the filament therethrough. A frame is configured to counter-rotatably support the rollers. The frame includes couplings configured to detachably receive distal ends of a support shaft and drive member extending from a drive mechanism, the drive member being configured to provide the rotational force to at least one of the rollers.

Abstract: Tissue fixation and repair constructs and methods of repair using the same are provided. An exemplary tissue fixation and repair construct can include a first implantable anchor coupled to a suture having a fixed tail and a tensioning tail. The fixed tail can include an overhand knot located distally adjacent to the finger trap, such that the overhand knot substantially abuts the finger trap when adjacent thereto, a fixed stopper knot configured to prevent further movement of the fixed tail through a second implantable anchor when the second implantable anchor is placed onto the suture, and a finger trap. The tensioning tail can be passed through the finger trap and overhand knot, and can be used to adjust the tension of the tissue fixation and repair construct when the first implantable anchor and the second implantable anchor are inserted into bone.

Abstract: A surgical access assembly includes a cannula including an elongated shaft and a retention anchor movably positionable along the elongated shaft. The retention anchor includes an annular body and a fixation body. The annular body includes a proximally-facing surface, a distally-facing surface, an inner side surface defining an opening therethrough, and an outer side surface. The fixation body includes a disc secured to the distally-facing surface of the annular body and wings extending radially outwardly from the disc beyond the outer side surface of the annular body. The disc defines an opening therethrough and the elongated shaft extends through the openings in the annular body and the fixation body.

Abstract: An apparatus and methods are provided for a syndesmosis treatment assembly that includes an insertion assembly and a syndesmosis suture construct for securing a first bone against a second bone. The syndesmosis suture construct is configured to be passed through a bone hole drilled across the first bone and the second bone and cinched to press the bones together. The insertion assembly includes a sleeve and a push rod for inserting the syndesmosis suture construct through the bone hole. The sleeve maintains the syndesmosis suture construct and the push rod in an elongate configuration suitable for being inserted through the bone hole. The push rod enables deploying a distal fixator comprising the syndesmosis suture construct to be anchored against a distal contact surface of the second bone. The sleeve and push rod are removable from the bone hole before the syndesmosis suture construct is cinched to secure the bones.

Abstract: Disclosed is a handle mechanism, including: a body, a first anchor delivery device provided to the body, a second anchor delivery device provided to the body, a tightening device provided to the body, and a locking and cutting device provided to the body. The first anchor delivery device is configured to control a first tissue anchor. The second anchor delivery device is configured to control a second tissue anchor. The tightening device is configured to pull a suture member.

Abstract: An apparatus and methods are provided for a syndesmosis treatment assembly that includes an insertion assembly and a syndesmosis suture construct for securing a first bone against a second bone. The syndesmosis suture construct is configured to be passed through a bone hole drilled across the first bone and the second bone and cinched to press the bones together. In an embodiment, the insertion assembly includes a sleeve and a push rod for inserting the syndesmosis suture construct through the bone hole. The sleeve maintains the syndesmosis suture construct in an elongate configuration suitable for being inserted through the bone hole. The push rod enables deploying a distal fixator comprising the syndesmosis suture construct to be anchored against a distal contact surface of the second bone. The sleeve and push rod are removable from the bone hole before the syndesmosis suture construct is cinched to secure the bones.

Abstract: A medical device for at least partially covering and applying force on tissue includes a body having a spanning structure and struts respectively connected to lateral portions of the spanning structure. Inner ends of the struts extend into an area over which the medial portion of the spanning structure extends. The medical device is reconfigurable between extended and retracted configurations. The inner ends of the struts are closer to one another in the retracted configuration than in the extended configuration. The inner ends of the struts are closer to the medial portion of the spanning structure in the retracted configuration than in the extended configuration. Each strut includes an engagement zone configured to engage and apply force on the tissue, at least while the medical device is in the retracted configuration. A web can be connected to the struts and span between the inner ends of the struts.

Abstract: A suture device includes a suture ring that defines an arcuate channel extending therein. A first arcuate needle passer is slidingly disposed within a first side of the arcuate channel and a second arcuate needle passer is slidingly disposed within a second side of the arcuate channel. An arcuate needle is passable between the first arcuate needle passer and the second arcuate needle passer and includes a first latching feature adapted to releasably secure the arcuate needle to the first arcuate needle passer and a second latching feature adapted to releasably secure the arcuate needle to the second arcuate needle passer.

Abstract: A suture device comprises a needle (5) which is movable between a retracted configuration and an extended configuration and a drive for rotating the needle between the retracted and extended configurations. The drive comprises an axle (18) which is rotated by a rack (12) and pinion (10) system.

Abstract: A tissue closure device includes a pusher assembly having a drive arm extending from a drive shaft and a needle driver at a distal end of the drive arm, wherein the needle driver is capable of releasably engaging and rotating a suturing needle having a pointed end and a blunt end about a rotational axis and a cartridge having a protective housing and the suturing needle, the cartridge extending from a distal end of a cartridge holder assembly and releasably attached to the cartridge holder assembly. A pointed end of the suturing needle may be positioned within the protective housing before and after a complete rotation of the suturing needle about the rotational axis. A removable electronic module may be provided controlled by an actuator that mechanically engages the drive shaft to rotate the drive shaft and the needle driver, thereby rotating the suturing needle about the rotational axis.

Abstract: The present disclosure provides a method for controlling a surgical instrument. The method includes connecting a power assembly to a control circuit, wherein the power assembly is configured to provide a source voltage, energizing, by the power assembly, a voltage boost convertor circuit configured to provide a set voltage greater than the source voltage, and energizing, by the voltage boost convertor, one or more voltage convertors configured to provide one or more operating voltages to one or more circuit components.

Abstract: The present disclosure provides a method for controlling a surgical instrument. The method includes connecting a power assembly to a control circuit, wherein the power assembly is configured to provide a source voltage, energizing, by the power assembly, a voltage boost convertor circuit configured to provide a set voltage greater than the source voltage, and energizing, by the voltage boost convertor, one or more voltage convertors configured to provide one or more operating voltages to one or more circuit components.

Abstract: A fixation device delivery system is described. The system includes a driver and a cooperating fixation element featuring a barb which becomes active upon deployment in the inner abdominal wall.

Abstract: A bone fixation system can be used to stabilize two bone portions intended to be fused together. The system include a bone staple or clip that includes a cross bar and two legs. The system can include a plurality of screws or other additional implant(s) configured to be implanted at an angle to the legs of the bone staple on opposite sides of the interface between two bone portions. The system can improve fixation strength and/or stability of the two bone portions. The fixation system can be used, for example, in small bones such as bones in the foot or hand.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for suturing a wound, incision, or other opening. In an illustrative embodiment, an apparatus includes a roller mechanism configured to counter-rotatably support two generally-parallel rollers configured to engage therebetween a shaft of a helically-shaped needle, the needle having a point at a leading end, drawing a filament from a trailing end, and having a first helical radius, the needle being revolvable around a first roller having a roller radius that is less than a helical radius of the needle to enable the needle to pierce a body and draw a filament through a body disposed adjacent the first roller. A motor drive is operably coupled with roller mechanism to convey rotational force to rotate the two generally-parallel rollers. A controller is operably coupled with the motor drive and configured to cause the needle to complete at least one revolution to form a single suture in the body.

Abstract: A surgical stapler body, a cartridge, a surgical stapler and a control method for the surgical stapler. The surgical stapler body includes an identification part capable of identifying information in a storage part that is connected to the cartridge assembly and capable of storing information of the cartridge assembly, the surgical stapler body further comprises a control unit capable of analyzing information stored in the storage part and sending an instruction, a power part capable of providing a power source for the surgical stapler body, and a driving part capable of driving the cartridge assembly to be closed. On the one hand, it is ensured that the driving part can drive the firing rod to move stably, so as to avoid a large vibration caused by manually operating the firing rod to influence the stitching, and reduce medical risk of human misoperation.

Abstract: Techniques for controlling an end effector include a computer-assisted device having a drive system configured to actuate a moveable element to a first commanded position and a control unit coupled to the drive system. The control unit is configured to actuate, using the drive system, the moveable element to the first commanded position. The control unit is further configured to monitor a force or torque applied by the drive system to actuate the moveable element to the first commanded position, determine a force or torque limit for the drive system based on the monitored force or torque applied by the drive system in response to determining that the moveable element has reached a first position, and further actuate the moveable element to a second commanded position while limiting a force or torque applied by the drive system based on the determined force or torque limit.

Abstract: A staple drive assembly includes an actuation sled and at least one staple pusher. The staple drive assembly is adapted to fit within a staple cartridge having a plurality of staples and a corresponding number of retention slots. The at least one staple pusher includes at least one pusher plate for releasably engaging a backspan of a staple. The staple pusher may include a plurality of pusher plates that may be laterally and longitudinally spaced apart. An actuation member has at least one angled camming surface for engaging a complimentary angled surface of the at least one staple pusher. Camming engagement between the actuation member and the at least one staple pusher causes vertical movement of the at least one staple pusher. Lateral and longitudinal offset of the actuation member camming surfaces and the corresponding staple pusher following surfaces improves stability and control of the staple pusher during firing.

Abstract: An Anastomosis Device is intended to create an end-to-side anastomosis between a graft vessel and a target vessel. The anastomosis is created by the delivery of staples that connect the graft vessel to the target vessel and the creation of an incision to open a flow path between the graft vessel and the target vessel.

Abstract: Adapter assemblies for connecting loading units to handle assemblies include a trocar assembly releasably securable within an elongate body by a retaining mechanism. The retaining mechanism includes first and second retention members pivotable between a locked position in which the first and second retention members are positioned to be received within respective first and second openings in a trocar housing of the trocar assembly when the trocar assembly is received within a distal portion of the elongate body, and a release position in which the first and second retention members are positioned to be spaced from the respective first and second openings in the trocar housing when the trocar assembly is received within the distal portion of the elongate body, wherein engagement of the first and second retention members with the seal member when in the locked position frictionally retains the first and second retention members in the locked position.

Abstract: Adapter assemblies include a trocar assembly releasably securable within an elongate body by a retaining mechanism. The retaining mechanism includes first and second retention members movable between a locked position in which the first and second retention members are positioned to retain the trocar assembly within the elongate body, and an unlocked position in which the first and second retention member are positioned permit release of the trocar assembly. Each of the first and second retention members includes a first camming surface configured to engage the trocar housing as the trocar assembly is received within the elongate body to move the first and second retention members to the unlocked position, and a second camming surface configured to engage the trocar housing when the trocar assembly is rotated about the longitudinal axis of the distal portion to move the first and second retention members to the unlocked position.

Abstract: Adapter assemblies include a trocar assembly releasably securable within an elongate body by a retaining mechanism. The retaining mechanism includes a housing, and first and second flexible arms extending from the housing. The first and second flexible arms each include a free end, and a locking portion disposed on the free end. The locking portions of the first and second flexible arms are positioned to be received within first and second cutouts of a trocar housing of the trocar assembly when the trocar assembly is received within the distal portion of the elongate body and in a first rotational orientation relative to the longitudinal axis, and the locking portions of the first and second flexible arms are flexed radially outward from the respective first and second cutouts when the trocar assembly is in a second rotational orientation relative to the longitudinal axis.

Abstract: An apparatus for controlling the flow of urine in a urethra of a patient, comprising an implantable adjustable constriction device for constricting the urethra, a control device for controlling the constriction device, an operation device for operating the constriction device to change the constriction of the urethra, and an energy source for supplying energy for the operation device. The control device comprises a temperature sensor configured to sense a temperature of the apparatus or a temperature of the patient.

Abstract: An intraoperative clip loading device includes an elongate body that can be positioned at a surgical site through a cannula during an endoscopic surgical procedure to provide a supply of ligation clips to the clip applier. The elongate body includes structure for supporting and advancing the ligation clips within the elongate body.

Abstract: An applicator capable of operating a clip unit including a first link, a medical apparatus including the applicator and the clip unit, and a method for operating the medical apparatus are disclosed. The applicator includes: a second link capable of engaging with the first link; an operation wire; a sheath capable of accommodating the second link; a slider that is connected to the operation wire and can be operated to move the second link; and a knob. In a state where the slider is in an advanced-most position, the knob can be operated to adjust the length of the wire extending from the slider to the second link between: a first length at which the second link protrudes from the sheath, and a second length that is shorter than the first length, and at which the second link is inside the sheath.

Abstract: An apparatus (500) for compressing a tumor in an organ of a body of a subject for increasing pressure within the tumor until causing ischemia and/or necrosis in the tumor. The apparatus includes an elongated body (501) for reaching surface of the organ via surgical access formed in the body. The apparatus includes a tightening mechanism (502) for tightening a tension member around a volumetric portion of organ and/or the tumor. The tightening mechanism includes a pulling member (504,505) and a force manipulator unit (513) for applying a tensioning force via the pulling member to force the tension member into a tightened state. The apparatus includes a securing mechanism (503) for securing first and second portions of the tension member for maintaining the tension member in the tightened state.

Abstract: A medical device includes: a clip; a wire configured to be capable of operating the clip; a link that detachably connects the clip and the wire; a sheath with an inner diameter that can accommodate the link; a handle connected to the sheath; a slider provided on the handle and configured to be movable relative to the handle, the slider being connected to the wire; a first sheath constituting the sheath, the first sheath having a length such that the link is arranged at a position protruding from the first sheath when the slider is advanced with respect to the handle to a maximum extent; and a second sheath constituting the sheath and connected to the first sheath, the second sheath having a length such that the link is arranged at a position accommodated in the sheath when the slider is advanced with respect to the handle to a maximum extent.

Abstract: Canalicular occlusion devices are described comprising an occlusive element and a memory frame comprising a memory material. The occlusive element is configured to substantially prevent fluid from flowing through portions of the canaliculus. Also disclosed are methods of occluding a canalicular system with the devices of the present invention.

Abstract: A medical system may include a left atrial appendage closure device including an expandable framework and a proximal hub centered on a central longitudinal axis of the framework. An insert may be disposed within the proximal hub and include a collar configured to engage the proximal hub, a recess extending into the insert from a proximal end, and a post member disposed within the recess. The post member may be radially spaced apart from the collar and may extend proximally from a distal end of the recess to a proximal surface. The insert may include a first connection structure disposed distal of the proximal surface. The medical system may include a delivery catheter having a second connection structure configured to engage the first connection structure in a delivery configuration. The distal end of the delivery catheter includes a hollow portion configured to receive the post member in the delivery configuration.