Abstract: The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface.

Abstract: Lubricious hydrophilic coatings and methods of making the same.

Abstract: An adhesion prevention material consisting of: (1) a first agent comprising a gelatin derivative, the gelatin derivative (a) including a structure represented by the following formula, GltnNH—CHR1R2, in the formula, Gltn represents a gelatin residue, R1 represents an alkyl group with 5 to 17 carbon atoms, and R2 represents a hydrogen atom or an alkyl group with 5 to 17 carbon atoms; (b) having imino group/amino group (molar ratio) of 1/99 to 30/70; and (c) having a weight average molecular weight of 10,000 to 50,000; and (2) a second agent comprising a crosslinker for the gelatin derivative.

Abstract: The invention relates to a method for lubricating a component consisting of a hydrophilic compound crosslinked by means of a water-soluble transition metal chelate.

Abstract: Provided is an antimicrobial composition comprised of at least one degradation product of oxidized cellulose (OC), such as oxidized regenerate cellulose (ORC), and minocycline, methods of preparation thereof and uses thereof.

Abstract: A blood processing filter includes a container having 2 ports respectively functioning as an inlet for a liquid to be processed and as an outlet for the processed liquid, and a filtration medium filled in the container, wherein an airflow resistance of the filtration medium is 55.0 kPa·s/m or more and less than 85.0 kPa·s/m, the filtration medium includes a filter material A having an airflow resistance per unit basis weight of 0.01 kPa·s·m/g or more and less than 0.04 kPa·s·m/g and a filter material B having an airflow resistance per unit basis weight of 0.04 kPa·s·m/g or more, at least a part of the filter material A is disposed on a side closer to the inlet for a liquid to be processed than the filter material B, and a sum of airflow resistances of the filter material A is 6.0 kPa·s/m or more.

Abstract: A blood purification apparatus including the following: a peristaltic pump that includes a stator to which a pump tube including a first portion and a second portion is detachably attached, and a rotor including a roller and a guide portion, the roller delivering liquid by squeezing the pump tube attached to the stator, the guide portion retaining the pump tube at an appropriate position where the pump tube is squeezable with the roller, the rotor being rotatable about a predetermined axis; an anchor member that anchors an attaching member to which the pump tube is attached; and a displacing portion that displaces the attaching member between a set position and an unset position by moving the anchor member with the attaching member being anchored by the anchor member.

Abstract: This disclosure relates to a blood treatment system including a blood treatment machine, a dialyzer configured to be coupled to the blood treatment machine, a blood line having a first end configured to be connected to the dialyzer and a second end configured to be connected to a needle for insertion into a patient, and one or more sensors operable to transmit, to the blood treatment machine, data related to tension along the blood line. The blood treatment machine is configured to take action in response to the data received from the one or more sensors.

Abstract: The invention relates to veterinary science. An extrarenal blood purification procedure is performed to remove toxins from the blood. Baseline parameters of urea and creatinine in the blood serum are measured during the blood purification procedure; on the basis of the data obtained, a dialysis intensity index (DII) is determined as the ratio of the patient's total fluid volume to the volume of the fluid purified of toxins and a uremic toxin accumulation index (UTAI) is determined as the rate of accumulation of the quantity of urea or creatinine per unit of time. Moreover, it is deemed necessary to repeat the hemodialysis procedure if the UTAI value for urea is more than 0.5 and/or the UTAI value for creatinine is more than 8, and/or the DII value is less than 0.9.

Abstract: Flow capture device and method for removing cells from blood The current invention discloses a blood treating and/or purifying device for removing circulating pathogens, preferably pathogenic cells, more preferably circulating tumor cells from the blood of a patient, a method of producing such a device and method to treat cancer and other diseases caused by virus infection, bacterial infection and parasites infection as well as autoimmune disorders. The described method is an extracorporeal medical therapy, thus can be done also in a hemodialysis system. The current invention also describes a device and an in-situ production method of preparing the device to remove CTC and other pathogens i.e. virus, bacteria or parasites from the bloodstream.

Abstract: A renal failure therapy system includes a dialysis fluid circuit including a dialysis fluid pump; a source of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit; a source of purified water in fluid communication with the dialysis fluid circuit; and a logic implementer in operable communication with the dialysis fluid pump, the logic implementer causing the physiological cleaning, disinfecting, and/or decalcifying substance from its source to be added to purified water from the purified water source to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump to at least one of clean, disinfect or decalcify at least a portion of the dialysis fluid circuit without a subsequent rinse.

Abstract: A lid that retains a pump tube which is elastic; a finger driving unit that is disposed facing the lid with the pump tube interposed therebetween, and that causes a plurality of fingers to sequentially move in the direction of contacting and separating from the lid; and a pump tube opening/closing mechanism that causes the finger driving unit to advance towards and retract from the lid, and that closes and opens the pump tube which is disposed between the fingers and the lid.

Abstract: A peritoneal dialysis system includes a water purifier, a cycler, and a disposable set operable with the cycler. The disposable set includes a pumping cassette including a water inlet port, a heater/mixing container in fluid communication with the pumping cassette, a water accumulator, a first water line segment, and a second water line segment. The first water line segment is in fluid communication with the water inlet port and the water accumulator. Additionally, the second water line segment is in fluid communication with the water accumulator and the water purifier.

Abstract: An attaching member attachable to a blood purification apparatus including a peristaltic pump, the attaching member holding a pump tube to be squeezed in a predetermined direction by the peristaltic pump for liquid delivery. The attaching member includes a body attachable to a predetermined position of the blood purification apparatus, and a holding portion attached to the body and that holds the pump tube. The holding portion holds the pump tube such that the pump tube is inclined in a direction in which the pump tube is attached to the peristaltic pump.

Abstract: A system for detecting whether a vascular access has been interrupted in an arrangement in which two catheters or needles are present in a blood vessel, fistula or graft. A fluid line leading to a pump is connected via a first connector to a first indwelling catheter, and a fluid line leading from a pump is connected via a second connector to a second indwelling catheter. Each connector is equipped with an electrode in contact with the lumen of the connector, the electrodes electrically connected to an electronic circuit that measures the impedance or conductivity of fluid between the first connector and second connectors via a fluid path through the blood vessel, fistula or graft. An electronic controller receives the impedance or conductivity data and processes the data to determine whether a vascular access disconnection has occurred.

Abstract: A device includes a processor and a non-transitory memory having processor-executable instructions stored thereon. The device is usable with a blood treatment apparatus, such as a hemodialysis machine. The processor-executable instructions, when executed by the processor, facilitate: determining a time point with regard to puncturing a vessel of a patient, wherein puncturing the vessel of the patient is related to a blood treatment for the patient using a blood treatment apparatus; determining a time period based on the determined time point; and transmitting data related to the determined time point and/or data related to the determined time period to a receiving device.

Abstract: Disclosed are a medical drainage monitoring method, apparatus, system based on image recognition. A medical drainage monitoring system comprises: a drainage device comprising a frame and a drainage container disposed in the frame, the drainage container having an inlet for receiving drained liquid; a first video acquisition device mounted on the frame aimed at the drainage container for obtaining video data of the drained liquid in the drainage container; an image processing circuit, configured to receive and process the video data from the first video acquisition device to obtain first drainage data of the drained liquid; and a monitoring circuit configured to monitor the first drainage data and trigger an alarm signal when the first drainage data violates a predetermined threshold.

Abstract: The present invention relates to an enema device comprising a delivery container arranged for accommodating an enema and an applicator nozzle for dispersing the enema, and wherein the delivery container is arranged as a hand held pump and wherein a cross-section of said delivery container has the shape of an oval. Thereby is provided a simple, inexpensive and essentially maintenance free enema device which can be used for self-administrating of an enema.

Abstract: A modular radio-labeling tracer synthesizer system comprising a housing having a plurality of slots containing syringe actuators. Each syringe actuator including a syringe holder, a syringe driver for driving a syringe plunger in a loading and/or dispensing direction. The unit is capable of adopting multiple configurations and is fully programmable and provides enhanced flexibility in development of novel radiotracers.

Abstract: A syringe nest assembly includes a base having a first surface and an opposing second surface and a first plate movably coupled to the base. The base includes a plurality of nesting units extending upwardly away from the first surface of the base. Each nesting unit includes a hollow body having a first open end distal from the first surface of the base and an opposing second open end. The first plate has a first surface and an opposing second surface. The first plate includes a plurality of apertures extending from the first surface to the second surface of the first plate. Each aperture of the first plate is generally aligned with a respective nesting unit of the base.

Abstract: A pump system including: a pump configured to intermittently perform an ejecting operation that ejects a fluid; a flow meter configured to measure a flow rate of the fluid ejected from the pump; and a control unit connected to the pump and the flow meter, configured to decide on a length of a stopping section during which the ejecting operation is stopped such that an ejection amount of fluid excessively ejected from the pump is canceled, based on a measured flow rate, which is the flow rate measured by the flow meter, and a target flow rate of the pump set in advance, and configured to control the pump so as to stop the ejecting operation according to the length of the stopping section.

Abstract: A frame for engaging at least two fluid containers includes: a first engagement member configured to secure at least a portion of one of the at least two fluid containers; a second engagement member configured to secure at least a portion of another one of the at least two fluid containers; and a body structure connected to the first engagement member and the second engagement member. The body structure is sized and shaped to index the at least two fluid containers with a powered injector system such that the at least two fluid injectors are held in an orientation and distance relative to each other for insertion into at least two pressure jackets associated with the powered injector system.

Abstract: The present disclosure provides a needle assembly and a drug injection device including a needle, a cannula into which the needle is inserted, a first holder supporting the needle, a second holder disposed to face one side of the first holder and supporting the cannula, a sleeve accommodating the first holder in an inner space and rotating with respect to the first holder, and an elastic member disposed between the first holder and the sleeve, wherein, when the sleeve is rotated, the elastic member is expanded and the first holder and the second holder are moved to an extended position, and wherein, when the sleeve is further rotated, the elastic member is contracted and only the first holder is returned to an original position.

Abstract: A medical device (1) for administering a medical fluid to a patient (4) comprises a housing (10) comprising a housing portion (11), a control device (19) for controlling operation of the medical device (1), a control element (18) placed on said housing portion (11) and being actuatable for entering a control command to be input to the control device (119), wherein the control element (18), for actuation, is at least one of rotatable about an axis of rotation (R) and linearly movable along the axis of rotation (R) with respect to said housing portion (11), and an actuation element (15) operatively connected to the control element (18) for actuating the control element (18). Herein, the actuation element (15) comprises a first knob element (17) operatively connected to the control element (18) and a second knob element (16) supported on said housing portion (11).

Abstract: According to various aspects of the present application, embodiments of an infusion pump for administering medication to a patient are provided. According to one embodiment, the infusion pump automatically determines time intervals and associated rates of infusion of the medication, and automatically controls a pump engine to infuse the medication for the determined time intervals at the associated rates of infusion. According to another embodiment, the infusion pump determines whether an infusion set is configured to infuse medication into a patient at one site or at two sites. The infusion pump then controls the pump engine based on the determined configuration of the infusion set. According to another embodiment, the infusion pump automatically primes the infusion set for infusion of medication into a patient. According to another embodiment, the infusion pump automatically determines whether one or more needles have been placed on the patient correctly.

Abstract: An implantable glymphatic pump configured to flush metabolites from a brain parenchyma of a patient. The implantable glymphatic pump including at least one spinal catheter having a distal end configured to be positioned within an intrathecal space of a spine of a patient, at least one cranial catheter having a distal end configured to be positioned within a brain parenchyma of the patient, and an implantable pump configured to draw cerebrospinal fluid from the intrathecal space of the spine in the patient via the at least one spinal catheter, and reintroduce said cerebrospinal fluid to the brain parenchyma of the patient via the one or more cranial catheters to encourage a flow of the cerebrospinal fluid through the brain parenchyma.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: The present disclosure describes embodiments of a patient monitoring system and methods that include the measure and display of hemoglobin statistics. In an embodiment, total hemoglobin trending is displayed over a period of time. Statistics can include frequency domain analysis, which may be unique for each patient monitored. The total hemoglobin trending and/or statistics can further be used to help control the treatment of a patient, such as being used to control IV administration.

Abstract: A system and method to configure a rule set used in connection with a medical monitoring system for monitoring patients and patient care equipment, especially medication delivery pumps, based on a variety of conditions and parameters associated with monitored biometric information and equipment information and for providing user-defined responses to those conditions and parameters.

Abstract: Proposed is a syringe for dermis regeneration, the syringe including: an injection unit having a first space therein and being open at a rear end portion, the first space being filled with a liquid or a gas and communicating with the outside; a needle combined with a front end portion of the injection unit and having a space therein, the space communicating with the first space; a liquid supply unit having a first end portion removably combined with the rear end portion, having a second end portion through which a piston moves, and having a space therein, the space being filled with the liquid and communicating with the first space, and the piston being inserted into the liquid supply unit; and a gas injection port passing through a sidewall of the injection unit and communicating with the first space to allow the first space to be filled with the gas.

Abstract: A medicament delivery device extends along a longitudinal axis and includes: a generally tubular elongated housing having a proximal and a distal end, where the generally tubular elongated housing is arranged to accommodate a medicament container; a drive unit comprising a drive element and plunger rod operably arranged to act on the medicament container; a tubular element rotatably arranged in relation to the housing and operably arranged to the plunger rod, where the plunger rod includes at least one holding member and where the tubular element includes at least one arm extending generally transversal to the longitudinal axis of the device, wherein the at least one arm is arranged to engage the at least one holding member on the plunger rod to releasable hold the drive unit in an energy accumulated state.

Abstract: Drug delivery devices and associated heating and/or cooling devices are disclosed. In an example, a drug delivery device includes a housing, a container, a therapy layer, and a first adhesive layer. The housing includes a top wall and a bottom wall. The container is at least partially disposed within the housing. The container has an inner volume to contain a drug. The therapy layer have a first side and a second side. The first side faces the bottom wall and the second side faces away from the bottom wall. The first adhesive layer couples the first side of the therapy layer and the bottom wall. The therapy layer is adapted to at least one of heat or cool an area adjacent an injection site.

Abstract: A system for a drug delivery device is provided. The system includes: a housing and a cartridge unit that is attachable to the housing or releasably attached to the housing. The cartridge unit includes a cartridge unit guide feature, the cartridge unit guide feature being provided to establish a guiding interface with the housing in order to guide relative movement of the cartridge unit and the housing with respect to one another when attaching the cartridge unit to the housing. The cartridge unit includes a cartridge unit interface feature, the cartridge unit interface feature being provided to form a further interface, in addition to the guiding interface, with the housing of the further interface being established when the cartridge unit is attached to the housing.

Abstract: The present invention relates to a prefilled glass container, such as a prefilled glass syringe, comprising an aqueous botulinum toxin formulation. The aqueous botulinum toxin formulation in the prefilled container is stable at low to ambient temperature for a prolonged time period. Furthermore, the present invention relates to a kit comprising the botulinum toxin prefilled container, and to the use of the botulinum toxin prefilled container in therapeutic and cosmetic applications.

Abstract: Provided herein are devices, systems, and methods for providing controlled delivery of a therapeutic substance during a surgical procedure, the devices and systems including a base, a frame having a proximal end and a distal end attached to the base, an injection subassembly including a plunger shaft, a relative motion subassembly including a lever plate, and a fastener configured to connect the plunger shaft of the injection subassembly and the lever plate of the relative motion subassembly.

Abstract: A medication delivery device is disclosed including a rack-and-pinion plunger drive system. The drive system includes an output drive having a pawled end movably coupled with the ratchet teeth of the plunger, and a pinion drive coupled between the housing, the output drive and an actuator. Actuator is longitudinally movable between dose set and delivery positions. Movement of the actuator causes rotation of the pinion drive along the rack to translate the output drive member with the pawled end that is engaged with the plunger ratchet teeth to distally advance the plunger. The device may include one or more of an end of dose mechanism to limit travel of the actuator, a load brake system to stop travel of the plunger under high input forces, a dose detection system, and a dose selector to vary the amount of dose set.

Abstract: A syringe assembly includes a main part with a bottom part and a top part. A compressible portion is connected to the top part, and a press unit is formed to the top the compressible portion. A needle is fixed to the top part and located within the compressible portion. The tip of the needle is located corresponding to a film of the press unit. The bottom part has a first lip and a second lip formed to the inner periphery thereof. The top part has a first groove and a second groove in the outer periphery thereof. Multiple collars are telescopically connected to each other, and are connected between the top part and the bottom part. The main part is located in the multiple collars. Each collar has two engaging portions which form two engaging grooves to be engaged with each other when collapsing the collars.

Abstract: In some embodiments, a delivery device includes a device actuator and a cannula portion through which a therapeutic substance is ejected. The cannula portion includes an outer shaft, a needle that is configured to move through the outer shaft, and a plunger that is configured to move through the needle, forming a positive displacement arrangement.

Abstract: The present disclosure relates to an injection device including: a housing; a carrier disposed within the housing for holding a syringe that has a needle at one end; a needle sleeve located within the housing and being axially moveable with respect to the housing between an extended position and a retracted position; a biasing element configured to bias the needle sleeve towards the extended position; and a locking mechanism configured to lock the needle sleeve in the extended position after use of the injection device, the locking mechanism comprising; a first locking member provided on and projecting from the carrier; and a second locking member comprising a deflectable arm provided on the needle sleeve and moveable between a relaxed position and a deflected position.

Abstract: The present invention provides a curved needle design which deflects to an advantageous angle when inserted within the medial posterior soft tissue of the patient lower jaw. The deflected needle tip is more perpendicular to the vertical wall of the posterior ramus and promotes the needle tip contacting bone proximate to the inferior alveolar nerve prior to injection of anesthetic. The needle design also improves the tactile feedback to the dental practitioner as the needle penetrates tissue and contacts bone.

Abstract: Improved apparatus for use with medication in fluid form, which is particularly beneficial for medications having a relatively high viscosity. The disclosed syringe adapter has an opening that is relatively large, as compared to a conventional needle, and thus affixing the disclosed syringe adapter to a syringe improves syringeability of higher-viscosity medications. Some embodiments feature a lateral extension that prevents inserting the syringe adapter too far into a medicine bottle, and some embodiments feature a component that assists in firmly grasping. When the disclosed syringe adapter is affixed to a pistol-grip or tab-handled syringe, the medication withdrawn into the pistol-grip syringe can be more easily administered from the syringe barrel. In some embodiments, the syringe adapter will be replaced with a needle prior to injecting the medication, while in some other embodiments, the needle is affixed to the in-place syringe adapter for the injection.

Abstract: An injection device is used for “tattooing” markers inside the heart of a patient at specific locations. Placement within the heart of markers, such as points marked with a radiopaque dye, may reduce the use of x-ray dye and echocardiography, may allow a quicker cardiac procedure, and thus may improve the procedure outcome for the patient. Alternatively or additionally to cardiac marking with a radiopaque dye, cardiac tissue fibrosis, cardiac tissue contraction, and/or cardiac tissue stiffening (or hardening) can be promoted at specific locations by delivering a suitable substance.

Abstract: A portable medical spray includes a tubular body, and a canister is located in the room. A needle is located in the room and a nozzle is formed to the top end of the body. The nozzle has a passage defined therethrough and the passage communicates with the room and the needle. A holding portion is formed to outside of the body. A connection portion extends from the bottom end of the body. The canister has medicine received therein and a breakable portion is formed to the top end of the canister and located corresponding to the needle. An end part is movable movably mounted to the connection portion. When a user pushes the end part to move the canister toward the needle, the needle penetrates through the breakable portion of the canister to release the medicine via the needle.

Abstract: An inhaler includes a body portion defining a flow path for the administration of medicament to a patient, and an entrained polymer in the flow path and being secured to or integral with the body portion. The entrained polymer has a monolithic material that includes a base polymer, an active agent (e.g., desiccant and optionally odor adsorber), and optionally a channeling agent. Optionally, the entrained polymer in a 16 gram quantity releases less than 4 parts per million volatile organic compounds after heating at 60° C. for up to 72 hours, optionally zero parts per million.

Abstract: Methods and devices for delivering one or more substances within at least one body cavity are provided. The device includes at least one nosepiece including at least one capsule having a volume Vsub of the substances; at least one base in communication with the nosepiece, the base including at least one chamber configured to confine pressurized fluid at volume VPF and pressure PPF; and at least one hollow puncturing member. The hollow puncturing member includes at least one end in fluid communication with the nosepiece and a second end in fluid communication with the base. The first and second ends are fluidly interconnected by a hollow tube. The fluid inlet port of the capsule is configured in terms of size and shape to interface in a sealable manner with the one end of the at least one puncturing member.

Abstract: A medicament device sensor (Sensor) comprises a body, a front wall, a back wall, an audio sensor, and a plurality of pressure sensors. The body includes a bottom surface on which the various sensors are coupled. The front wall and the back wall provide mirror symmetry in at most one plane, thereby defining a single orientation in which the Sensor attaches to the medicament device. The front wall includes a securement clip that attaches to a ledge on the medicament device. To detect secure attachment of the Sensor to the medicament device, one pressure sensor detects pressure when the Sensor is secured to the medicament device. Another one or more pressure sensors detect depression of one or more dosing buttons confirming priming of the medicament device. The audio sensor detects an inhalation confirming dispensing of medicament. In effect, the Sensor determines a dispensing event has occurred.

Abstract: An inhaler device for delivering a powder substance contained in a capsule includes a main body having a first body portion and a second body portion jointly defining a first capsule seat part adapted to retain a first capsule part. The first and second body portions are hinged to each other so as to be rotatable between a closed main body position, adapted to retain the first capsule part in the first capsule seat part, and an open main body position adapted to allow expulsion of the first capsule part from the first capsule seat part. A slider, formed by a first slide portion and a second slide portion jointly defining a second capsule seat part adapted to retain a second capsule part, is slidingly housed in the main body.

Abstract: A device for releasing discrete doses of medicament carried in a plurality of spaced-apart compartments on a medicament carrier, each compartment being arranged in a carrier strip and sealed by a sealing layer, the device comprising: a release mechanism arranged to engage between the carrier strip and the sealing layer so as to unseal at least a portion of the compartment and expose the medicament dose contained therein, wherein the release mechanism preferably covers said exposed compartment in place of the sealing layer.

Abstract: A hand-held device for metered dispensing of sprayable substances, in particular inhaler medicaments, includes a housing and a cartridge which can be displaced into a dispensing position by a pressure application relative to the housing, wherein the housing has a mouthpiece, wherein the cartridge can be displaced initially into a ready-to-dispense position and a dispensing spray process can be triggered by sucking in, wherein the displacement of the cartridge can be executed by tensioning a spring supported on the housing and acting on the cartridge. The spring is displaced into the position to perform a spraying process, but is hindered by a counterforce that can be deactivated by application of a negative pressure through the mouthpiece of the hand-held device A valve flap is moved by the negative pressure and cancels a mechanical block of the movement of the cartridge.

Abstract: Described is a manual artificial respiration bag (1) having a deformable bag (2) with a gas inlet (4), a gas outlet (3) and an inner volume (5); a downstream conduct element (100) fluidly connected to the gas outlet (3) and comprising an exhaust valve (110) with an exhaust port (111); a downstream one-way valve (50, 55) arranged into the downstream conduct element (100) that is configured for allowing a flow of respiratory gas to pass through said downstream one-way valve (50, 55) only toward the exhaust valve (110). The manual artificial respiration bag (1) further has a mobile port-closure (124), actuatable by a user, cooperating with the exhaust port (111) of the exhaust valve (110) for at least partially closing said exhaust port (111) thereby controlling the flow of respiratory gas passing through the exhaust port (111) of the exhaust valve (110).