Abstract: An optical apparatus includes an optical system that forms an optical image, a moving frame that holds at least part of the optical system, a fixed frame that encompasses the moving frame and slidably holds the moving frame in an optical axis direction of the optical image, a coil configured to generate a magnetic field to drive the moving frame along the optical axis and at least two magnets disposed at a position where torque with a predetermined moment is generated around an axis parallel to the optical axis by a magnetic force in the moving frame. The at least two magnets include a first magnet and a second magnet that are disposed such that a midpoint of a line connecting respective centers of the first magnet and the second magnet on a cross section orthogonal to the optical axis falls within a cross-sectional region of the moving frame.

Abstract: A medical device may comprise a sheath configured to be inserted into a body lumen of a patient. A distal end of the sheath may include an elevator for changing an orientation of a medical device. A handle may include an actuator. The actuator may be operably connected to the elevator. Activation of the actuator may cause movement of the elevator. An engaging portion may, in at least one configuration of the handle, protrude from a surface of a handle body toward the actuator. A force exerted by the user on at least one of the actuator or the engaging portion may cause the handle to transition between (a) a first configuration in which the engaging portion interacts with the actuator to inhibit movement of the actuator relative to the engaging portion and (b) a second configuration in which the actuator is movable relative to the engaging portion.

Abstract: A medical device may comprise a distal tip having a viewing element, a lighting element, and at least one feature configured to removably couple the distal tip to a shaft. The medical device may also comprise a working channel coupled to the distal tip and defining a central lumen configured to receive a tool. A wall of the working channel may define at least one additional lumen. The working channel may be configured to be removably inserted into the shaft. The medical device may also comprise at least one of a wire, a cable, or a conduit passing through the at least one additional lumen.

Abstract: Minimizing image sensor input/output pads in a pulsed laser mapping imaging system is disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a plurality of bidirectional pads comprising an output state for issuing data and an input state for receiving data. The system includes a controller configured to synchronize timing of the emitter and the image sensor. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises a laser mapping pattern.

Abstract: Methods and apparatus for treating disorders of the ear, nose, throat or paranasal sinuses, including methods and apparatus for dilating ostia, passageways and other anatomical structures, endoscopic methods and apparatus for endoscopic visualization of structures within the ear, nose, throat or paranasal sinuses, navigation devices for use in conjunction with image guidance or navigation system and hand held devices having pistol type grips and other handpieces.

Abstract: A device to check the quality and dosage of anesthetic dispensing device that is used for the application of anesthetic fluids using a spray nozzle is provided. This device can be adapted for use in the oral cavity and upper tracheal area of a medical patient prior to intubation of such patient. The present device comprises of a camera system, a stroboscopic lighting system, and an image analysis software.

Abstract: A vaginal speculum and system include a plurality of pivoting blades coupled to a housing having an aperture. The plurality of pivoting blades is coupled to a cam plate, and upon rotation of the cam plate, the plurality of pivoting blades and configured to go from a collapsed state to an expanded state. The system further includes an insert having a vaginal seal at a distal end and a plurality of ports at a proximal end. The vaginal speculum and system are configured for use in medical diagnostic and treatment procedures by opening the vagina of a patient in multiple directions for mitigating potential obstruction of view such that a practitioner may fully visualize the cervix and properly inspect and diagnose cervical conditions or the absence thereof.

Abstract: An ophthalmic stimulator for temporarily constricting a pupil of an eye comprises an irradiation control system, having a feedback system, to generate an irradiation control signal using a feedback of the feedback system; an irradiation source, coupled to the irradiation control system, to generate an irradiation; and an irradiation delivery system, having a targeting system and coupled to the irradiation control system, to receive the irradiation from the irradiation source, and to direct a patterned irradiation in a pattern to a treatment region of an iris of the eye using the targeting system; wherein the irradiation control system controls at least one of the irradiation source and the irradiation delivery system with the irradiation control signal so that the patterned irradiation causes a temporary constriction of the pupil, without causing a permanent constriction of the pupil.

Abstract: Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. An optical diagnostic method for an eye includes obtaining a sequence of aberration measurements of the eye, identifying an outlier aberration measurement of the sequence of aberration measurements, and excluding the outlier aberration measurement from the sequence of aberration measurements to produce a qualified sequence of aberration measurements. The sequence of aberrations measurements can be obtained by using a wavefront sensor. An optical correction for the eye can be formulated in response to the qualified sequence of aberration measurements.

Abstract: A method for virtual reality-based visual field inspection according to an embodiment is a method that performs a visual field inspection on a head-mounted display. The method includes: outputting a background including a background image and a focus point image; outputting an indicator on the background; and sensing user input from an examinee according to output of the indicator.

Abstract: The present invention provides a morphology determining method of corneal topography, including: a parameter obtaining step, based on an original contour line of a cornea of a target subject as the reference, obtaining a relative displacement of each observation point of a contour line of the pressed cornea changed with time from the beginning of pressing the cornea by an external pressure to a predetermined time after the pressing is finished; a conversion step, performing a mathematical function conversion of the above relative displacement with respect to a spatial contour at each observation time point, so as to respectively obtain one or more order vibrational modes representing the contour line of the time points; and a determining step, respectively comparing the one or more order vibrational modes of the cornea of the target subject with a corresponding order vibrational mode of at least one reference cornea, and determining a morphology of the corneal topography of the cornea of the target subject.

Abstract: A device for visualizing an irido-corneal angle of an eye through a window of a patient interface configured to be placed on the eye includes and optics structure and at least one imaging apparatus. The optics structure is configured to engage with the patient interface to provide a line of sight through the window in the direction of the irido-corneal angle, and to subsequently disengage from the patient interface. The imaging apparatus is associated with the optics structure and aligned with the line of sight to enable capturing an image of the eye including the irido-corneal angle.

Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.

Abstract: A computing system comprising one or more electronic computing devices receives data from a hearing-assistance device. The computing system determines, based on the data received from the hearing-assistance device, a cognitive benefit measure for a wearer of the hearing-assistance device. The cognitive benefit measure being an indication of a change of a cognitive benefit of the wearer of the hearing-assistance device attributable to use of the hearing-assistance device by the wearer of the hearing-assistance device. The computing device outputs an indication of the cognitive benefit measure.

Abstract: A method of using bidirectionally a sensor platform incorporated into a garment of a wearer using a plurality of sensed biometric data, the method comprising: receiving from sensors of the sensor platform a set of the plurality of biometric data; sending the set to network device associated with the sensor platform; receiving a response including a command from the network device; and applying the command via one or more actuators of the sensor platform to effect a change in an operational characteristic of at least one of the sensors of the sensor platform.

Abstract: An optical analysis of saliva or a fluid-saliva mix obtained during or after an oral care action is performed in order to check whether the saliva or fluid-saliva mix contains blood, which allows for determining whether or not a person may suffer from gingivitis or another condition affecting gum health. In particular, light received from a representative sample (23) containing saliva is detected and analyzed. The analysis involves determination of measurement values of light received by a light-receiving unit (25) for one or more main wavelengths of the light and one or more auxiliary wavelengths of the light. Advantageously, the main wavelength(s) is/are associated with high hemoglobin absorption and the auxiliary wavelength(s) is/are associated with low hemoglobin absorption. A measurement value at an auxiliary wavelength is used for correcting a measurement value at as main wavelength for background influences.

Abstract: Disclosed is an optical dental caries diagnostic device and an optical diagnostic device for periodontal diseases that can quantitatively diagnose progression of dental caries or periodontal diseases, and an optical diagnostic method including the same. Also disclosed is a diagnostic system including such diagnostic devices. The optical dental caries diagnostic device (1) has a probe (30) having optical transparency and a taper shape with an end portion to be in contact with a tooth, a light source (20) emitting light to the probe (30), and a light receiving element (40) receiving light from the end portion of the probe (30).

Abstract: Diagnosing and treating viral infections. One example is a method of diagnosing absence of severe acute respiratory syndrome 2 (SARS-CoV-2), the method including: isolating a human in a covid-free environment for an isolation period; performing measurements of a core temperature during the isolation period; and if each of the measurements of the core temperature indicate a lack of fever, declaring the human free of SARS-CoV-2. Another example is a method including treating coronavirus in a human by: receiving a core temperature measurement; receiving a test result regarding the SARS-CoV-2 virus; responsive to the human having both fever and the presence of the SARS-CoV-2 virus, submerging the trunk and the legs of the human in water with a surfactant, and the human at least partially submerged for a treatment period of at least three hours; and controlling a temperature of the water during the treatment period.

Abstract: A physiological signal processing method includes the following steps: receiving a plurality of ECG signals and user information; capturing the ECG signals; detecting the displacement state of the ECG monitoring device to obtain three-axis data; calculating the heart rate based on an ECG or the ECG signals, and calculating an activity amount based on the three-axis data; and generating an activity intensity based on the activity amount, the user information, and the heart rate.

Abstract: An instrument and method for non-invasively deriving at least one biometric datum of a living vertebrate. A sensor positioned against the vertebrate measures vibrations within its body. The sensor provides the samples to the instrument as at least one time-stamped stream that correspond to one or more linear and/or rotational acceleration measurement axes. The instrument organizes the samples into windowed streams, separates them into a first set of streams corresponding to physical events of the vertebrate associated with cardiovascular activity and a second set of streams corresponding to physical events of the vertebrate associated with respiration. A datum can be extracted from the first set by autocorrelating it with a time-delayed version thereof to identify at least one characteristic peak of the vertebrate's cardiac cycle. A datum can be extracted from the second set by determining a characteristic frequency of respiration of the vertebrate.

Abstract: System for determining a blood pressure (BP) of users, comprising: for each user, a signal module configured to cooperate with a wearable device destined to be worn on a wrist of the user and comprising a pulsatility sensing unit; the signal module comprising a controlling module for controlling the pulsatility sensing unit to measure a plurality of pulsatility signals at the user's wrist; a processing module for processing the pulsatility signals to obtain pulsatility signal data; and a communication module for remotely transmitting said pulsatility signal data; the system further comprising an external service module including a database storage system for storing in a database the transmitted pulsatility signal data for each user; and a calculating module configured for calculating a BP value for each user, based on the pulsatility signal data stored in the database.

Abstract: An example method includes (a) generating, via a sensor of a computing device, a signal representing vibrations originating from a blood vessel of a subject, where the vibrations are indicative of heart beats and/or respirations of the subject; (b) using the signal to determine first times elapsed between respective pairs of consecutive heartbeats indicated by the vibrations and/or second times elapsed between respective pairs of consecutive respirations indicated by the vibrations; and (c) using the determined first times elapsed to determine a heart rate variability of the subject and/or the determined second times elapsed to determine a respiration rate variability of the subject.

Abstract: Provided is a blood pressure measurement device capable of discharging a fluid from three cuffs even when either one of a pump valve or an on-off valve fails, that includes a pump including a pump valve; a first flow path including a first on-off valve and fluidly connecting the pump and a sensing cuff; a second flow path branching from the first flow path between the pump and the first on-off valve, including a second on-off valve, a third on-off valve, and a fourth on-off valve, and connecting the pump and atmosphere; a third flow path branching from an intermediate portion between the second on-off valve and the third on-off valve and fluidly connecting the pump and the tensile cuff; and a fourth flow path branching from an intermediate portion between the third on-off valve and the fourth on-off valve and fluidly connecting the pump and the pressing cuff.

Abstract: An ambient monitoring device includes a housing, contactless sensors coupled to the housing, and a processing device disposed in the housing. The processing device is coupled to the contactless sensors. The processing device is to receive, from one or more contactless sensors of the plurality of contactless sensors, historical sensor data. The processing device is further to determine baseline vital signs based on the historical sensor data. The processing device is further to receive, from the one or more contactless sensors, current sensor data associated with a user that is within a threshold distance of the ambient monitoring device without contacting the ambient monitoring device. The processing device is further to determine, based on the current sensor data, current vital signs of the user. Responsive to determining the current vital signs do not meet the baseline vital signs, the processing device is to provide an alert.

Abstract: To provide an information processing apparatus, an information processing method, and a program that can provide a time for an individual according to how the individual feels the flow of time. Provided is an information processing apparatus including: an information acquisition unit (320) that acquires a temporal change in biological information from one or a plurality of biological information sensors worn by a user; and a calculation unit (332) that calculates a difference between a temporal change in first biological information in a first section and a temporal change in second biological information in a second section having a same time as the first section at predetermined time intervals and calculates a time difference with respect to a standard time.

Abstract: A method and a system to monitor the progression of a pulmonary ailment in patients who are mechanically ventilated or spontaneously breathing. By delivering specific gases to the patient and monitoring the release of those gases over various timescales, the system monitors the progression of pulmonary shunt. No invasive procedures are required, and the system is able to operate through the sole delivery and monitoring of respiratory gases.

Abstract: Systems, methods, apparatuses, and computer program products for reconstructing electrocardiogram (ECG) waveforms from photoplethysmogram (PPG) signals using dictionary learning and deep learning for continuous monitoring and analytics. A method may include obtaining an electrical signal of a heart. The method may also include obtaining a circulatory signal related to a pulsatile volume of blood in tissue. The method may further include preprocessing the electrical signal and the circulatory signal. In addition, the method may include learning a mapping from at least one of the preprocessed electrical signal and the preprocessed circulatory signal. Further, the method may include training a model using the mapping. The method may also include deriving cardiovascular data based on the trained model.

Abstract: To calibrate a differential pressure measurement to a geodetic height difference of (approximately) zero, a reference position determination part is led close up to the blood pressure measuring device where a calibration signal is triggered if a minimum distance is not reached between two respective points defined at the reference position determination part and a blood pressure measuring device. A control device integrated in or connected to the blood pressure measuring device performs the calibration measurement in response to the trigger signal. The triggering means are implemented, e.g., as an RFID tag on the reference position determination part-side and an associated near-field communication reader on the blood pressure measuring device-side. If the near-field communication reader detects the correctly encoded RFID tag in the reference position determination part, it triggers the calibration signal.

Abstract: The present disclosure provides methods and systems for diagnosing and treating fibromyalgia in a patient. In one method, a pressure value is obtained for the patient, wherein the pressure value is determined by inserting a needle of a device into a location in the patient, injecting saline solution into the patient at the location, and measuring a pressure at the location; and fibromyalgia is diagnosed in the patient if the pressure at the location exceeds a threshold pressure value. The present disclosure also provides a device for use in the methods of the disclosure. One such device includes a needle, a syringe including a saline solution, a tube positioned between the syringe and the needle, and a pressure sensor configured to obtain a pressure value at a muscle location of a patient.

Abstract: A method for analyzing an electrocardiography (ECG) signal is provided. The ECG signal is measured through a sensor. One or more specified waveforms in the ECG signal are detected. Multiple ECG features from each specified waveform are captured. The ECG features are input into multiple candidate models to obtain multiple candidate scores. Each candidate score is compared with a standard value to obtain an ideal score among the candidate scores. One of the candidate models corresponding to the ideal score is selected as a risk prediction model to predict disease risk through the risk prediction model.

Abstract: Provided are coil assemblies, and holding assemblies, devices and systems comprising the coil assembly as well as methods of use thereof. The coil assembly includes a first radio frequency coil element configured for transmitting a first radio frequency signal through a region of interest of a subject or test sample, the first radio frequency signal for exciting a first spin species in the region of interest. The coil assembly also includes a second radio frequency coil element configured for resonating at a second radio frequency signal to receive a magnetic resonance signal from a second spin species from the region of interest. The first radio frequency signal and the second radio frequency signal are separated by a frequency interval. A drive circuitry is connected to the second radio frequency coil element. A first decoupling circuit prevents coil coupling between the first radio frequency coil element and/or a transmitter coil element.

Abstract: An apparatus and method are provided to simultaneously provide good image quality and fast image reconstruction from magnetic resonance imaging (MRI) data by selecting an appropriate value for the regularization parameter used in compressed sensing (CS) image reconstruction. In CS reconstruction a high-resolution image can be reconstructed from randomized undersampled data by imposing sparsity in multi-scale transformation (e.g., wavelet) domain. Further, in the transformation domain, a threshold can be determined between signal and noise levels of the transform coefficients. A regularization parameter based on this threshold scales the regularization term, which imposes sparsity, relative to the data fidelity term in an objective function, thereby balancing the tradeoff between noise and smoothing.

Abstract: A non-invasive drug release monitoring and quantification method and system is provided using magnetic particle imaging to monitor in vivo drug release. A living body is imaged with a magnetic particle imager after the living body has been injected with a nanocomposite composed of a biodegradable polymer shell layer containing a cluster of magnetic nanoparticles and a drug. A magnetic particle signal is detected and obtained which represents the release of magnetic nanoparticles from the PLGA shell layer, which is the result of a disassembly of the biodegradable polymer shell layer due to biological degradation of the biodegradable polymer shell layer in an acidic environment of the living body resulting in drug release and magnetic nanoparticle release. The release of the drug in the living body is quantified using a previously obtained reference linear relationship defined between the magnetic particle signal and the drug release rate.

Abstract: A system for monitoring hydration status of a human body is provided. The system comprises a plurality of sensors adapted to perform bio-impedance measurements at predefined locations on the body, thereby generating respective measurement data. The system further comprises a processing unit adapted to receive and to process the measurement data in order to estimate a body composition parameter for the respective locations on the body. In this context, at least one sensor is adapted to perform bio-impedance measurement at the throat region or esophagus region in order to detect a swallowing or fluid intake event.

Abstract: The present invention provides a MEMS sensor guidance system mounted on a surgical instrument and uses the MEMS sensor to determine Inertial Measurement Units to track rotation and acceleration in all three spatial directions. Further the invention provides a method of surgery in which a reference axis, a loci, and a depth are defined and the instrument including the sensor duster of the invention is placed in relation to the y-axis and x-axis and following the working end is aligned and the orientation and depth data display is observed to aid in maintaining the desired instrument.

Abstract: Systems and methods to determine a composite respiration phase of a patient are disclosed, including a signal receiver circuit to receive first and second physiologic information of a patient, and an assessment circuit to determine first respiration phase information of the first physiologic information and to determine the composite respiration phase of the patient using the determined first respiration phase information and the second physiologic information.

Abstract: A device for detecting and quantifying lung function includes a piezoelectric sensor configured for attachment to a mammalian chest wall and to feed signals to an ADC providing digitized signals to a processor. The processor firmware extracts inspiration and expiration times from the digitized signals and generates an I/E ratio from them. The processor has firmware to detect wheezing sounds in the signals. The device has an analog event detector configured to wake-up the processor upon detection of candidate wheeze sounds in the signals. In embodiments, the analog event detector includes bandpass filters coupled to a modeling circuit feeding a correlation circuit, the filters having bandpass adjusted by feedback from a circuit within the analog event detector. In an embodiment, the device uses an FFT with a gated recurrent unit (GRU) with partial reset (GRUPR) neural network to detect wheezes.

Abstract: The present invention provides a pneumonia detection device for detecting an exhaled air of a patient to determine whether the lungs of the patient have been infected by at least one bacterial species. The device comprises a multi-gas sensing module, a temperature and humidity control module, and an operation control unit. The multi-gas sensing module comprises a gas sensor array reacting with a gas metabolized from the bacteria to generate a plurality of characteristic signals. The temperature and humidity control module controls and measures an operational condition of 45° C.-60° C. and humidity between 7% and 20% for the gas sensor array. The gas sensor array contacts with the exhaled air to generate a plurality of measurement signals. The operation control unit comparisons the measurement signals and the characteristic signals of different bacteria to generate a result determining whether the patient has contracted the bacteria.

Abstract: An apparatus assesses a condition of a patient. The apparatus may contain a patient interface for communicating a treatment generated by a respiratory treatment apparatus to the respiratory system of a patient. The apparatus may also include a sensing module containing one or more electrochemical sensors to sense chemicals in exhaled breath in real time, or over an extended period of time. The apparatus may also include one or more collectors to accumulate a breath condensate over an extended period of time. The sample collectors may contain an absorbent material, and may also be adapted for replacement within a sensing module. The absorbent material may also include a preservative for preserving a chemical component of the breath, such as an analyte of the exhaled breath.

Abstract: The disclosure relates to a method and a device for obtaining a breath sample of a test person, wherein the test person inhales a droplet mist which is preferably colder than the ambient temperature. The material exhaled and/or ejected by the test person is collected as a breath sample in one or more collection vessels.

Abstract: A method of avoiding a contaminant which would skew an analyte result in a breath analysis method and of calibrating subject of the breath analysis includes, immediately before the breath analysis method or the collection of breath for the breath analysis method, administering to the subject a predetermined gas composition. A system for analyzing an analyte in breath of a subject while avoiding a local contaminant which would skew an analyte result and calibrating the subject of so that the result of the analyte analysis will be the same regardless of where the test is performed geographically, includes a source of a predetermined gas composition immediately before the breath analysis method or the collection of gas for the breath analysis method, administering to the subject a predetermined gas mixture.

Abstract: Systems and methods are provided for estimating 3D poses of a subject based on tactile interactions with the ground. Test subject interactions with the ground are recorded using a sensor system along with reference information (e.g., synchronized video information) for use in correlating tactile information with specific 3D poses, e.g., by training a neural network based on the reference information. Then, tactile information received in response to a given subject interacting with the ground can be used to estimate the 3D pose of the given subject directly, i.e., without reference to corresponding reference information. Certain exemplary embodiments use a sensor system in the form of a pressure sensing carpet or mat, although other types of sensor systems using pressure or other sensors can be used in various alternative embodiments.

Abstract: Systems and methods in accordance with many embodiments of the invention include a motion evaluation system that trains a model to evaluate motion (such as, but not limited to, gait) through images (or video) captured by a single image capture device. In certain embodiments, motion evaluation includes predicting clinically relevant variables from videos of patients walking from keypoint trajectories extracted from the captured images.

Abstract: A patient support apparatus includes a plurality of primary sensors adapted to measure different parameters used in the control of the patient support apparatus. One or more suites of secondary sensors are added to the patient support apparatus to provide data about the primary sensors. The secondary sensors may be used to detect errors in the primary sensors, to modify outputs from the primary sensors, and/or to provide usage and/or diagnostic data about the use of the patient support apparatus. The suite(s) of secondary sensors may measure parameters that affect the outputs of one or more of the primary sensors. In some embodiments, the suite(s) of secondary sensors include one or more dormant sensors that are not used on the patient support apparatus until a code modification is received from one or more external sources instructing the control system of the patient support apparatus to begin using the dormant sensor(s).

Abstract: Systems and methods for analysis of symmetry between sides of a body. A wearable device includes a body mounting portion structured and arranged to, in use, be mounted to one or more parts of a body of a patient on one side of the body. The wearable device includes at least one sensor configured to output a signal indicative of at least one physiological parameter from a side of the body to which the wearable device is mounted. At least one processor is configured to receive at least one physiological parameter from the wearable device while mounted to a first side of the body, and at least one physiological parameter from the wearable device while mounted to a second side of the body. An indicator of symmetry between the first side and the second side of the body is determined based at least in part on the at least one physiological parameter from the first side of the body and the at least one physiological parameter from the second side of the body.

Abstract: A device that enables an assessment or a management of a medical condition in a patient, includes a base member comprising a pair of surface spaced apart from each other to define a thickness of the base member. The base member can be provided as an elongated base member. Markings are disposed on one surface from the pair of surfaces of the elongated base member along a length of the elongated base member. An array of targets is provided with targets being disposed, during use of the device, below a bottom edge of the elongated base member. Coupling members are also provided with each coupling member coupling a respective target from the array of targets to the elongated base member for a reciprocal linear movement along the length of the elongated base member. The device can be affixed to a structure or provided as a mobile device.

Abstract: This invention is smart clothing which enables human motion capture through combined analysis of data from dual inertial sensors and dual stretch (or bend) sensors. In a preferred embodiment, a first inertial motion sensor is located proximal to a body joint, a second inertial sensor is located distal to the body joint, and two stretch sensors span the body joint in different configurations.

Abstract: A method for conducting a cross frequency simultaneous masking (xF SM) test begins with generating a signal probe and a masker probe. The center frequencies of the signal and masker probes are separated by a fixed frequency ratio. An xF SM curve is generated by sweeping the signal and masker probes across a given frequency range, while maintaining the fixed frequency ratio between the two. While sweeping, the masker probe is maintained at a pre-determined masker amplitude or a series of pre-determined masker amplitudes. The amplitude of the signal probe is adjusted in response to a series of user inputs, which are then interpolated to generate the xF SM curve. Additionally, while sweeping, the signal probe can be maintained at one or more pre-determine amplitudes and the amplitude of the masker probe adjusted in response to user inputs, which are then interpolated to generate the xF SM curve.

Abstract: A composite material for detecting and measuring levels of analytes and target molecules in biological fluid and tissue is disclosed herein. This composite material is constructed from a porous mesh sheet that is coated with a signal emitting material and is impregnated with target detecting molecules mixed inside one or multiple polymer mixtures. The geometry and configuration of different constituents can provide high efficiency of signals, the ability to measure multiple signals, small dimensions, fast response to changes, long storage lifetimes, controlled diffusional and mechanical properties, as well as easy industrial manufacturability. The composite material can be used in many sensing applications including optical or electrochemical continuous biosensing such as continuous glucose and lactate monitors.

Abstract: Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.