Abstract: The invention concerns a device for quantifying the dexterity of the fingers of a hand, comprising a main body, several systems for measuring the movement and/or the force applied by a finger in a pressure direction, each system for measuring comprising a sensor for deformation, the sensor for deformation comprising a deformable body, characterized in that each system for measuring also comprises a guide bearing, integral with the main body, a shaft having a bearing surface, the bearing surface being in contact with the deformable body, a tube, adapted to slide in translation in the guide bearing and around the shaft in the pressure direction, having a head adapted to fix the finger to the tube, a first spring connecting the bearing to the tube, a second spring connecting the shaft to the tube, the first spring and the second spring being pre-tensioned, so as to pre-tension the deformable body.

Abstract: A method for obtaining blood glucose concentration using near infrared spectroscopy (NIR) data is provided. The method includes obtaining, by an independent component analysis (ICA) temporal module, orthogonal pure spectra from human NIR spectra; performing, by a processing module, one or more preprocessings and drift removal on the human NIR spectra and the orthogonal pure spectra to obtain preprocessed spectra; and obtaining, by a regression block, the blood glucose concentration from the preprocessed spectra.

Abstract: Hypoglycemic event prediction using machine learning is described. A CGM platform includes a machine learning model trained using historical time series glucose measurements of a user population. Once trained, the machine learning model predicts hypoglycemic events for users. When predicting hypoglycemic events, a time series of glucose measurements for a day time interval is received. The glucose measurements of this time series for the day time interval are provided by a CGM system worn by the user. The machine learning model predicts whether a hypoglycemic event will occur during a night time interval that is subsequent to the day time interval by processing the time series of glucose measurements using the trained machine learning model. The hypoglycemic event prediction is then output, such as via communication and/or display of a notification about the hypoglycemic event prediction.

Abstract: A blood glucose measurement device and a blood glucose measurement system using the same are proposed, the device being non-invasive, measuring blood glucose with sweat rather than blood, having a sweat-inducing means that requires no drug in a sweat induction process, and including: a sweat-inducing part having two electrodes arranged to be spaced apart from each other and to which opposite polarities are respectively applied; a housing for fixing the sweat-inducing part allowing the two electrodes to be exposed on one surface of the housing; and a blood glucose sensor inserted into the housing and in contact with body fluids induced by the sweat-inducing part, whereby pain, infection, and scars do not occur, the drugs that may affect the normal sweat-inducing mechanism in the skin are not used, and all the collected sweat is used to measure the blood glucose level with high-accuracy.

Abstract: A non-invasive method to determine a current functional blood oxygen saturation level (SpO2): a—acquiring, at a sampling frequency, a photoplethysmography light response for each wavelength of a plurality of at least three wavelengths (?1, ?2, ?3), resulting respectively in a first, second and third raw data series, b—applying a low-pass filter to each of the first, second and third raw data series, resulting respectively in a first, second and third DC data series representing an unmodulated amplitude response c—determining respectively in a first, second and third AC data series representing an unmodulated amplitude response, d—applying a computation engine to the first, second and third AC and DC data series, and determining therefrom a user current blood oxygen saturation level.

Abstract: Some embodiments are directed to a system and method monitoring oxygenation in biological tissue, comprising a control unit configured and operable to receive data indicative of light response from a region of the biological tissue being subjected to illumination and/or collection at two separate wavelengths in two selected wavelength ranges and processing the data by comparing data indicative of each selected wavelength range to determine an oxygenated/deoxygenated status of the biological tissue. The two wavelength ranges include a first wavelength range in which the absorbance of the deoxyhemoglobin within the tissue is higher than the oxyhemoglobin, and a second wavelength range in which the absorbance of the oxyhemoglobin within the tissue is higher than the deoxyhemoglobin or vice versa. The two wavelengths in the two wavelength ranges include first and second wavelengths satisfying a predetermined condition of a ratio between the absorbance of the deoxyhemoglobin and oxyhemoglobin for each wavelength.

Abstract: A system includes an enclosure having a processor and a memory coupled to the processor. The enclosure includes a display coupled to the processor where the display is visible from an exterior of the enclosure; and a battery within the enclosure coupled to the processor and the display. The enclosure includes a probe tip coupled to an exterior of the enclosure. The probe tip includes first, second, and third sensor openings. A first distance between the first and second sensor openings is different than a second distance between the first and third sensor openings. The enclosure includes code stored in the memory where the code is executable by the processor, and includes code to receive first data associated with the first and second sensor openings, code to receive second data associated with the first and second sensor openings, and code to perform SRS using the first and the second data.

Abstract: A surgical instrument may be configured to sense a light re-emitting probe to resolve tissue oxygenation, the surgical instrument including: an optical emitter configured to excite the light re-emitting probe within an absorption band of the light re-emitting probe; an optical detector configured to receive the re-emitted light from the probe; and a signal processor configured to resolve the tissue oxygenation based on the received light. The surgical instrument can be a surgical stapler anvil or a flexible substrate having a tissue interfacing surface. Further, a monitoring device may be configured to map oxygenation of a tissue containing a light re-emitting probe, the monitoring device including: an optical emitter configured to excite the light re-emitting probe; at least one optical detector configured to receive the re-emitted light from the probe; and a signal processor that is configured to resolve the tissue oxygenation at multiple points to generate an oxygen map.

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Abstract: Images of an individual can be obtained and analyzed to determine an amount of facial paralysis of the individual. The images can also be analyzed to determine an amount of gaze deviation of the individual. The amount of facial paralysis of the individual and/or the amount of gaze deviation of the individual can be used to determine a probability that the individual experienced a biological condition.

Abstract: Deception can be evaluated by presenting a set of sentences or words to a testee, including some sentences or words that are expected to evoke significant pupil dilation in a testee who is lying and other sentences or words that are not expected to evoke significant pupil dilation in the testee. Changes in the testee's pupil size are compared to ascertain whether a pupil-dilation response to certain sentences or words is larger than for other sentences or words, and an indication of deceptiveness or non-deceptiveness is output based on the results of the ascertaining.

Abstract: Deception can be evaluated by presenting a set of sentences or words to a testee, including some sentences or words that are expected to evoke significant pupil dilation in a testee who is lying and other sentences or words that are not expected to evoke significant pupil dilation in the testee. Changes in the testee's pupil size are compared to ascertain whether a pupil-dilation response to certain sentences or words is larger than for other sentences or words, and an indication of deceptiveness or non-deceptiveness is output based on the results of the ascertaining.

Abstract: A multi-lumen catheter for monitoring intra-abdominal pressure, the catheter including an expandable outer balloon and an expandable inner balloon positioned within the outer balloon. A first lumen communicates with the inner balloon and the inner balloon and first lumen are filled with gas to form a gas filled chamber to monitor pressure within the bladder to thereby monitor pressure within an abdomen of the patient. A second lumen communicates with the bladder to remove fluid from the bladder. The catheter is configured for attachment of an external pressure transducer communicating with the gas filled chamber for measuring bladder pressure based on gas compression caused by deformation of the expanded inner balloon deformed by the expanded outer balloon.

Abstract: A probe assembly comprising: an electrode-based probe comprising a probe head and one or more slender electrodes extending from the probe head for insertion into biological tissue; and a support element disposed around one or more of said electrodes, distal from the probe head, the support element comprising one or more apertures through which said one or more electrodes pass, the probe head and said electrode(s) being movable relative to the support element during insertion; wherein the support element is configured to constrain the angle of the end of the said electrode(s) at the point of insertion into the tissue.

Abstract: A sensor (30) for measuring a biological potential of an individual, comprising: a measurement electrode (31) comprising a base (32), at least one leg intended to come into contact with an anatomical zone of the individual and at least one electrical connection member (38), at least one locking member (45) configured to cooperate in a reversible manner with at least one complementary locking member (25) on an external support (10) so as to removably fasten the sensor (30) to the external support (10), the locking member (45) being separate from the electrical connection member (38), a protection element (40) made from a resilient material and delimiting a recess (41) in which the leg extends.

Abstract: A bioelectrode includes a support member, an electrode member of conductive rubber, including a supported part that is a member to be supported by the support member and at least one electrode part that is a member protruding from the supported part, and a snap-button-type connector that is provided on the support member, and that electrically connects the electrode member to outside. The snap-button-type connector and the supported part are integrally molded.

Abstract: A pediatric electrocardiogram electrode and cover are provided. The pediatric electrocardiogram electrode and cover includes an electrode. The electrode includes an interface that is designed to connect to an electrocardiogram machine. The electrode also includes a gel surface that conducts electrical currents through the electrode. A cover is sized to cover the electrode. The electrode includes an adhesive surface to secure the cover thereon. The cover includes a pair of arms that can overlap to secure the cover to the electrode.

Abstract: A method, including receiving a bipolar signal from a pair of electrodes in proximity to a myocardium of a human subject, and receiving a unipolar signal from a selected one of the pair of electrodes. The method further includes delineating a window of interest (WOI) for the unipolar and bipolar signals, within the WOI computing local unipolar minimum derivatives of the unipolar signal, and times of occurrence of the local unipolar minimum derivatives, and within the WOI computing bipolar derivatives of the bipolar signal at the times of occurrence. The method also includes evaluating ratios of the bipolar derivatives to the local unipolar minimum derivatives, and when the ratios are greater than a preset threshold ratio value, assigning the times of occurrence as times of activation of the myocardium, counting a number of the times of activation; and classifying the unipolar signal according to the number.

Abstract: Fast recovery electrocardiogram (ECG) signal method and apparatus are provided. In one embodiment, an ECG apparatus includes an input for receiving a biometric cardiogram signal, such as a Wilson Central Terminal (WCT) signal, and a combiner, such as an adder, for producing a compensated signal. Processing circuitry produces an ECG reflective of the compensated signal and also outputs a signal corresponding to high frequency response of the compensated signal to compensate for low response of the biometric cardiogram signal to high frequency spikes. A resultant ECG is produced by the processing circuitry having pacing signal contribution within the biometric cardiogram signal cancelled.

Abstract: Provided is a method for displaying electrocardiogram (ECG) data for the detection of myocardial ischemia, wherein a map is configured in the form of concentric circles using ST segments obtained through ECG measurement such that the inner circle consists of a “depression” origin and the outer circle consists of an “elevation” origin so as to display by connecting graphs or dots according to the measured ECG values of limb leads (frontal plane leads; I to aVF) and chest leads (precordial plane leads; V1 to V6), and the intuitive confirmation of the presence of subendocardial ischemia or transmural injury is enabled through the map, thereby making it possible to quickly and accurately recognize the patient's conditions and inducing prompt treatment.

Abstract: Techniques are disclosed for using both feature delineation and machine learning to detect cardiac arrhythmia. A computing device receives cardiac electrogram data of a patient sensed by a medical device. The computing device obtains, via feature-based delineation of the cardiac electrogram data, a first classification of arrhythmia in the patient. The computing device applies a machine learning model to the received cardiac electrogram data to obtain a second classification of arrhythmia in the patient. As one example, the computing device uses the first and second classifications to determine whether an episode of arrhythmia has occurred in the patient. As another example, the computing device uses the second classification to verify the first classification of arrhythmia in the patient. The computing device outputs a report indicating that the episode of arrhythmia has occurred and one or more cardiac features that coincide with the episode of arrhythmia.

Abstract: A determination device (100) for determining the origin of an arrhythmia and a mapping system (200) are disclosed. In the determination device (100), an analysis unit (120) is configured to process ECG data extracted over a predetermined period of time by a data extracting unit (110) and input the processed data into a determination model (131), where a calculation is performed thereon to produce origin information about the origin. An output unit (140) is configured to output the origin information, and a model configuration unit (130) is configured to configure the determination model (131). The determination device (100) allows identifying a cardiac site suitable for focused mapping, thereby dispensing with the need to map the whole heart and shortening the time required for mapping. The mapping system (200) includes the determination device (100).

Abstract: Described herein are methods, devices, and systems that improve arrhythmia episode detection specificity, such as, but not limited to, atrial fibrillation (AF) episode detection specificity. Such a method can include obtaining an ordered list of R-R intervals within a window leading up to a detection of a potential arrhythmia episode, determining a measure of a dominant repeated R-R interval pattern within the window, and comparing the measure of the dominant repeated R-R interval pattern to a pattern threshold. If the measure of the dominant repeated R-R interval pattern is below the pattern threshold, that is indicative of a regularly irregular pattern being present, and there is a determination that the detection of the potential arrhythmia episode does not correspond to an actual arrhythmia episode. Such embodiments can beneficially be used to significantly reduce the number of false positive arrhythmia detections.

Abstract: This invention relates to an ex vivo use of the instantaneous frequency modulation (iFM) signal of cardiac activations and to an ex vivo use of the instantaneous amplitude modulation (iAM) signal obtained from the sequence of amplitude excursions of said activations for detecting ‘driver’ or ‘high-hierarchy’ regions and/or the cardiac spots that display the footprint of rotational activations in the heart of a subject with cardiac fibrillation without requiring panoramic simultaneous acquisition.

Abstract: Techniques are disclosed for explaining and visualizing an output of a machine learning system that detects cardiac arrythmia in a patient. In one example, a computing device receives cardiac electrogram data sensed by a medical device. The computing device applies a machine learning model, trained using cardiac electrogram data for a plurality of patients, to the received cardiac electrogram data to determine, based on the machine learning model, that an episode of arrhythmia has occurred in the patient and a level of confidence in the determination that the episode of arrhythmia has occurred in the patient. In response to determining that the level of confidence is greater than a predetermined threshold, the computing device displays, to a user, a portion of the cardiac electrogram data, an indication that the episode of arrhythmia has occurred, and an indication of the level of confidence that the episode of arrhythmia has occurred.

Abstract: This disclosure describes systems and methods for electrocardiographic waveform analysis, data presentation and actionable advisory generation. Electrocardiographic waveform data can be received from a wearable device associated with a patient. A mathematical analysis can be performed on the electrocardiographic waveform data to provide cardiac analytics. A visualization of the cardiac analytics on a dashboard display can be generated. A value can be based on a comparison of the cardiac analytics to at least one baseline value for the patient; and a decision of whether or not to generate an actionable advisory for the electrocardiographic waveform data can be made based on the value. When the actionable advisory is generated, the actionable advisory is sent to one or more medical professionals, where it can be modified, and displayed with the visualization of the cardiac analytics.

Abstract: In alternative embodiments, provided are products of manufacture, including devices and integrated systems, and methods, for reducing error-related negativity (ERN) and anxiety, and for treating or ameliorating Anxiety Disorders such as Generalized Anxiety Disorder (GAD) or Social Anxiety Disorder (SAD) and obsessive-compulsive disorder (OCD).

Abstract: An electrode for use in ambulatory BEG signal collection includes an electrode contact comprising a gelatin or hydrogel polymer having low input impedance. The electrode contact retains adhesive ability and low input impedance over long periods of time. A system using the electrode includes circuits and software for analyzing EEG signals to detect and report ictal events in real time. At least part of the system is wearable; and advantageously part of the system resides in a cloud based system. A signal analyzer incorporated in the system provides real time ictal signal identification through physical graphing and cross-correlation. In some aspects the analyzer also provides confirmation of ictal signal identification by physical graphing and machine deep learning. Analysis of physical graphs may conveniently be performed using a graphics processing unit to speed processing.

Abstract: Example aspects of a volatile organic compound detection device, a wearable health monitoring device, and a method of monitoring a user's health are disclosed. The volatile organic compound detection device can comprise a collector comprising a collector material configured to collect volatile organic compounds given off from a user's skin; a separator comprising a gas chromatography column configured to separate mixtures of the volatile organic compounds into their constituent chemicals; and an identifier comprising a detector and a processor, the detector configured to transduce the the constituent chemicals into a signal, the processor configured to process the signal to identify specific volatile organic compounds indicative of a health condition.

Abstract: A measuring device is provided with an improved contact property of a measuring surface of a sensor with respect to a surface of a target object. The measuring device includes a main body and a probe that has a head section at the distal end thereof and an arm section connecting the head section to the main body. The head section has a support portion, a measuring portion, and a coupling portion. The support portion is connected to the distal end of the arm section. The measuring portion has a first surface at which a measuring surface of a sensor is exposed and a thickness with the first surface as a datum plane. The coupling portion is disposed between and couples the measuring portion and the support portion. The coupling portion has a first connection portion connected to the measuring portion and a through hole.

Abstract: Systems and methods for assessing milk volume changes within a breast are described. Also described are systems and methods for assessing volume changes in the stomach of an infant.

Abstract: This present invention discloses a fetal monitoring device that enables the monitoring of an unborn baby's heartbeat and its movements inside the womb. The fetal monitoring device includes an elastic strap with a fetal monitor disposed centrally on the strap. The fetal monitoring device is worn such that the strap fits to the abdomen of the pregnant woman, and the fetal monitor is placed adjacent to the location of the fetus, so as to monitor the fetus' condition and further project real-time imagery of the unborn baby on a related display device.

Abstract: Facial skin analysis methods and systems for improving facial skin conditions using vehicle cameras of vehicles having onboard communication modules. Each vehicle is equipped to analyze the facial skin images over time periods and compare the images to determine skin conditions. Based on the facial skin conditions, a treatment recommendation can be transmitted to a seat occupant. Each vehicle is operatively connected to a facial skin analysis application in a data center. The facial skin analysis application includes a registration module which registers each vehicle. Additionally, a vehicle user may register with the facial skin analysis application to have his/her facial skin analyzed when travelling in any of the plurality of vehicles. The facial skin analysis application is operatively connected to a skin data AI analytics module and data lake and searches a plurality of databases for information related to the facial skin conditions to improve the treatment recommendation.

Abstract: A device for photographing a human face comprising: a) a light-excluding housing configured to receive a human face at an aperture in said housing; and b) a stand on which the light-excluding housing is mounted at one or more (preferably two rotatable pivot points, such that rotation about said pivot points results in movement of the aperture upwards and/or downwards.

Abstract: System, apparatus, and method for automatic detection of arthritis according to temperature asymmetry estimation in contralateral joints is presented. Simultaneously recorded thermogram and the optical image of an inspected joint and its contralateral joint are sent to the processing unit, where they are stored, processed, and analyzed. The system, apparatus, and method automatically detects outlines of joints in thermograms and optical images. Grid of points of interest is distributed inside the inspected and the contralateral joint's outline. Temperature maps are calculated according to both grids points and the temperature disparity map is estimated. The set of inflammation regions is obtained by analyzing the temperature disparity map and collecting adjacent points containing temperature differences surpassing the threshold. The system, apparatus, and method are non-invasive and non-contact, and suitable for real world environments with natural home or health care institutions background.

Abstract: A surgical probe for augmenting artificial intelligence (AI) based anatomical recognition. Preferably the medical device probe is applied to any body cavity or space for which an image can be obtained and the medical device probe delivered to the target tissue captured on the image (i.e. endoscopic, arthroscopic, or other minimally invasive surgical procedures) in order to train and augment anatomical recognition models. The probe may provide reference points, markings, surface contours, size and scale representations, dye marking, spatial cues, light refraction, sonic propagation and other modalities for determining tissue properties and biomechanical characteristics. A data set of device probe augmented medical images and video are captured from the procedure and used to train the AI based recognition algorithms.

Abstract: The invention relates to a system, in particular an NFB system, and method which permits the treatment of addictions, of the types involving the insular cortex, of an individual in need thereof, with low relapse rates.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Abstract: Systems and methods for use in monitoring one or more physiological parameters of a user. The system comprises: at least one sensing unit comprising at least one vibration sensor; and at least one elastic tube configured to be embedded within a cushioning layer for supporting at least a portion of the user. One end of the at least one tube is sealed and the other end of the at least one tube is closed by the at least one sensing unit so as to form a volume that is filled with fluid and that is defined by one or more inner walls of the tube and a surface of the at least one sensing unit. The at least one elastic tube is configured to transmit vibrations from one or more sections of the at least one tube to the at least one sensing unit for detection by the at least one vibration sensor.

Abstract: A sleep apnea and obesity comorbidity treatment system includes a transceiver and a control module. The control module is configured to: receive sensor data, where the sensor data is indicative of a glucose level of a patient and a ketones level of the patient, transmit the sensor data to a remote feedback device, receive feedback information from the remote feedback device based on the sensor data, and where the feedback information provides indications to the patient to maintain or alter a behavior of the patient based on the glucose level and the ketones level, and based on the feedback information, performing an operation to maintain or alter at least one of a diet or physical activity of the patient.

Abstract: A method for diagnosing a malady of a patient from sounds of the patient including the steps of: making a digital recording of the sounds of the patient; processing the digital recording to extract a multiplicity of features for sub-segments of each of a number epochs of the digital recording; determining deviation scores from a probability distribution for each epoch based on extracted multiplicity of features; applying a test vector derived from the deviation scores to a pre-trained decision machine; and presenting a diagnosis of the malady on the basis of an output from said decision machine.

Abstract: A method for configuring a prosthesis and/or orthosis or for determining malpositions in the set-up of a prosthesis or orthosis of the lower limb. The method includes recording a first set of measurement data of at least one sensor that is fixed to a body part of a person, wherein the first set of measurement data is allocated to a first state of movement of the person, recording a second set of measurement data of at least one sensor that is fixed to a body part of a person, wherein the second set of measurement data is allocated to a second state of movement of the person, and evaluating the first and second set of measurement data.

Abstract: Systems, devices and methods are provided for neuromonitoring, particularly neuromonitoring to reduce the risks of contacting or damaging nerves or causing patient discomfort during and after surgical procedures, including spinal surgeries. The neuromonitoring procedures include monitoring for the presence of or damage to sensory nerves, and optionally includes additional monitoring for motor nerves. In some systems, including systems that monitor for both sensory and motor nerves, components of the monitoring systems (e.g., stimulating electrodes and response sensors), may be combined with one or more surgical instruments. The systems, devices, and methods provide for pre-surgical assessment of neural anatomy and surgical planning, intraoperative monitoring of nerve condition, and post-operative assessment of nerve position and health.

Abstract: Disclosed are sensor devices, systems, and methods for performing electrochemical measurements. The sensor device includes a flexible orthodontic device substantially cylindrical in shape with a hole in an end configured to allow saliva to pass. The device further includes one or more valves to allow the saliva to pass in a forward direction through the flexible orthodontic device and not in a reverse direction, and one or more electrochemical electrodes configured to contact the saliva, wherein the one or more electrodes are configured to determine the presence of one or more chemical biomarkers in the saliva.

Abstract: A system for performing measurements on a biological subject, the system including: at least one substrate including a plurality of plate microstructures configured to breach a stratum corneum of the subject; at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure response signals from the at least one microstructure; and, one or more electronic processing devices configured to: determine measured response signals; and, at least one of: provide an output based on measured response signals; perform an analysis at least in part using the measured response signals; and, store data at least partially indicative of the measured response signals.

Abstract: Systems and methods are disclosed for proximity sensing in physiological sensors, and more specifically to using one or more proximity sensors located on or within a physiological sensor to determine the positioning of the physiological sensor on a patient measurement site. Accurate placement of a physiological sensor on the patient measurement site is a key factor in obtaining reliable measurement of physiological parameters of the patient. Proper alignment between a measurement site and a sensor optical assembly provides more accurate physiological measurement data. This alignment can be determined based on data from a proximity sensor or sensors placed on or within the physiological sensor.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: A sensing guidewire device used to measure physiological parameters within a living body. In one embodiment, the device is used to measure the fractional flow reserve (FFR) across a stenotic lesion in a patient's vasculature. The device includes a sensor that is adapted to be affixed near the distal end of a guidewire. The guidewire contains a corewire, processed to enclose electrical conductors in a sealed, off-centered interstice or channel, with an outer diameter approximate to the outer diameter of the device, running substantially the full length of the device, and has a homogenous outer surface. The enclosed eccentric channel provides space for electrical conductors to move freely. The corewire can have a tapered segment to create desirable flexibility. A solid connector comprised of alternating conductive and insulating elements for connecting the conductors to an external device is disclosed.