Patents Issued in April 7, 2022
  • Publication number: 20220104722
    Abstract: According to some aspects, a magnetic resonance imaging system capable of imaging a patient is provided. The magnetic resonance imaging system comprising at least one B0 magnet to produce a magnetic field to contribute to a B0 magnetic field for the magnetic resonance imaging system and a member configured to engage with a releasable securing mechanism of a radio frequency coil apparatus, the member attached to the magnetic resonance imaging system at a location so that, when the member is engaged with the releasable securing mechanism of the radio frequency coil apparatus, the radio frequency coil apparatus is secured to the magnetic resonance imaging system substantially within an imaging region of the magnetic resonance imaging system.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 7, 2022
    Applicant: Hyperfine, Inc.
    Inventors: Anne Michele Nelson, Christopher Thomas McNulty, Jeremy Christopher Jordan, Michael Stephen Poole, Gang Chen
  • Publication number: 20220104723
    Abstract: A device for treating an aneurysm of a human or mammal patient, wherein the aneurysm may self-expand, leading to the aneurysm bursting with high risk for death of the human or mammal patient. The device comprising an implantable member adapted to be placed in connection with the outside of a blood vessel having the aneurysm, and to exercise a pressure on the outside of the blood vessel having the aneurysm, a measuring device or sensor for measuring or sensing an expansion of the aneurysm, and a pressure regulator adapted to regulate the exercised pressure on the outside of the blood vessel having the aneurysm.
    Type: Application
    Filed: October 18, 2021
    Publication date: April 7, 2022
    Inventor: Peter Forsell
  • Publication number: 20220104724
    Abstract: A computer system receives sensor measurements from a respiration sensor. The computer system generates a particular set of data features from the sensor measurements. The computer system then processes the particular set of data features through a computer-based ataxic breathing rating algorithm. The computer system displays on a user interface an ataxic breathing rating that is calculated from the computer-based ataxic breathing rating algorithm.
    Type: Application
    Filed: January 7, 2020
    Publication date: April 7, 2022
    Inventors: Lara M. Brewer CATES, Robert J. FARNEY, Sean C. ERMER, Joseph A. ORR
  • Publication number: 20220104725
    Abstract: An artificial intelligence-based system and method for scalable screening of individuals for respiratory infection, such as COVID-19. The system is trained to distinguish distinct latent features of cough sounds produced by a COVID-19 infected person from cough sounds produced by patients suffering from any other respiratory infection or involuntary cough sounds produced by a healthy person. Cough sound samples from individuals can be remotely collected and evaluated by the system for likelihood of the COVID-19 infection. Additionally, images of affected body parts, biomarkers, metadata, and other respiratory sound samples can also be used for screening.
    Type: Application
    Filed: July 13, 2021
    Publication date: April 7, 2022
    Inventors: Ali Imran, Iryna Posokhova, Ali Rizwan
  • Publication number: 20220104726
    Abstract: The embodiments disclose a method including making electrodes using an electrically conductive material for impedimetric detection of analytical targets in an electrochemical sensing platform device, collecting patient samples in a solution compartment of the electrochemical sensing platform device, binding primers and aptamers to electrodes for functionalizing electrodes for detecting and binding targeted viruses and bacterial pathogens, incubating oral fluid samples in the solution compartment using a heater, measuring electrode impedance changes, recording measured electrode impedance changes in a memory device, and integrating wireless technologies into the electrochemical sensing platform device configured for transmitting recorded measured data.
    Type: Application
    Filed: October 18, 2021
    Publication date: April 7, 2022
    Inventor: Gregory J. Hummer
  • Publication number: 20220104727
    Abstract: The present invention relates to a device for measuring the circumference of an object, in particular a device for measuring the circumference of a body part.
    Type: Application
    Filed: February 6, 2020
    Publication date: April 7, 2022
    Inventor: Joseph Harfouche
  • Publication number: 20220104728
    Abstract: The present invention relates to a device and a method for detecting whether a bedridden person is getting out of bed or has fallen out of their bed. The device performs an analysis over time of the distances between the sensors of a detector and the objects that are present in the detection field of the detector. The detection is based on variations in said distances and of the locations thereof within the monitored space.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 7, 2022
    Inventor: Philippe Kaplan
  • Publication number: 20220104729
    Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the distal motor function of a subject having a muscular disability, in particular SMA by active testing of the subject.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian GOSSENS, Michael LINDEMANN, Florian LIPSMEIER, Detlef WOLF
  • Publication number: 20220104730
    Abstract: The present disclosure discloses system and method for detecting behavioral disorder of a person in early stage. The claimed system including: a plurality of camera modules for capturing videos of the person, wherein the captured videos are utilized to observe behavior of the person; a processing unit connected with the plurality of camera modules to pre-process the captured videos for generating behavioral disorder report of the person; a motion detection sensor connected with the processing unit for detecting motion of the person from the captured videos; an extractor connected with the motion detection sensor for extracting features from the captured videos; and a classifier connected with the extractor to differentiate abnormal behavior from normal behavior of the person.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 7, 2022
    Inventors: Yousef S. Alsahafi, Talal M. Alasmari
  • Publication number: 20220104731
    Abstract: A glucose-specific sensor has a glucose limiting layer (GLL), an enzyme layer and an interference layer. The GLL comprises polyurethane with a molecular weight greater than 100,000 Daltons that is physically crosslinked with a water-soluble polymer having a molecular weight greater than 100,000 Daltons. The interference layer has a polymer formed from pyrrole, phenylenediamine (PDA), aminophenol, aniline, or combinations thereof. Methods for making a glucose-specific sensor include mixing a monomer with a solvent to form a monomer solution, applying the monomer solution to a substrate and electropolymerizing the monomer to form a polymer on the substrate. The polymer is an interference layer for the glucose-specific sensor. An enzyme layer is formed on the interference layer, and a glucose limiting layer is formed on the enzyme layer.
    Type: Application
    Filed: September 29, 2021
    Publication date: April 7, 2022
    Applicant: Zense-Life Inc.
    Inventors: Huashi Zhang, Robert James Boock, Michael Wheelock, Mark Wu, Qinyi Yan, Yubin Huang, Steven Soto, Jessie Haskamp
  • Publication number: 20220104732
    Abstract: A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. In a preferred embodiment, the at least one antimicrobial material is LL-37.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Georgetown University
    Inventors: Makarand Paranjape, Shruti M. Paranjape
  • Publication number: 20220104733
    Abstract: A working wire for a continuous biological sensor is disclosed and includes a substrate having a conductive surface and an enzyme layer formed on the conductive surface. The enzyme layer includes enzymes, an immobilization matrix and a polymeric crosslinking agent that crosslinks the enzymes and the immobilization matrix creating an enzyme immobilization network. A protective layer is included over the enzyme layer. A method for making the working wire for a continuous biological sensor is disclosed and includes combining an enzyme with a solvent creating an enzyme mixture. An immobilization matrix is mixed with the enzyme mixture. After the mixing, a polymeric crosslinking agent is combined with the enzyme mixture and the immobilization matrix creating a crosslinked mixture. The crosslinked mixture is allowed to stabilize. The stabilized crosslinked mixture is applied to the working wire, and the applied mixture is cured on the working wire.
    Type: Application
    Filed: September 30, 2021
    Publication date: April 7, 2022
    Applicant: Zense-Life Inc.
    Inventors: Mark Wu, Huashi Zhang, Robert James Boock, Yubin Huang, Qinyi Yan, Michael Christophe Walsh
  • Publication number: 20220104734
    Abstract: Subject matter disclosed herein relates to monitoring and/or controlling blood glucose levels in patients. In particular, times for obtaining metered blood glucose samples of a patient may be altered based, at least in part, on a blood glucose level of said patient observed from a blood glucose sensor.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 7, 2022
    Inventors: Rebecca K. Gottlieb, Meena Ramachandran
  • Publication number: 20220104735
    Abstract: An apparatus for non-invasively estimating an analyte concentration is provided. The apparatus for estimating an analyte concentration includes: (1) a signal measurer including: an optical coherence tomography (OCT) device configured to emit an OCT signal to an object and receive the OCT signal reflected or scattered from the object; and a spectrometer configured to emit a spectrometer signal to the object and obtain a spectrum based on the spectrometer signal reflected or scattered from the object, and (2) a processor configured to predict a path length distribution for each wavelength in a predetermined wavelength range, based on the OCT signal, and estimate a concentration of an analyte based on the predicted path length distribution and the obtained spectrum.
    Type: Application
    Filed: April 7, 2021
    Publication date: April 7, 2022
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jun Ho LEE, Sung Mo AHN
  • Publication number: 20220104736
    Abstract: A method of determining concentration of an analyte in a body fluid using a mobile device having a camera is disclosed. In the inventive method, the camera is used to take a series of calibration images of a region of interest of an object. The calibration images differ in their brightness. A key calibration figure is derived from each calibration image, the key calibration images being characteristic for a tone mapping function of the mobile device. A probable tone mapping function of the mobile device is determined by taking into account the key calibration figures. An analysis image is taken of at least part of a test field of an optical test strip, the test field having a body fluid applied thereto. Analyte concentration is determined from the analysis image of the test field by taking into account the probable tone mapping function of the mobile device.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Inventors: Max Berg, Fredrik Hailer, Bernd Limburg, Daria Skuridina, Volker Tuerck, Momme Winkelnkemper
  • Publication number: 20220104737
    Abstract: In some examples, a system includes an oxygen saturation sensing device configured to sense an oxygen saturation level of a patient and processing circuitry. The processing circuitry may be configured to receive a signal indicative of the oxygen saturation level of the patient, determine that the signal indicates the oxygen saturation level is at or below a desaturation threshold, and in response to determining the oxygen saturation level of the patient is at or below the desaturation threshold, predict, using an oxygen saturation prediction model, whether the oxygen saturation level of the patient will increase above the desaturation threshold by the end of a predefined time period. In response to predicting that the oxygen saturation level of the patient will increase above the desaturation threshold by the end of the predefined time period, the processing circuitry refrains from outputting an indication of the patient experiencing an oxygen desaturation event.
    Type: Application
    Filed: October 1, 2020
    Publication date: April 7, 2022
    Inventors: Philip C. Smit, Andre Antunes, Dean Montgomery, Paul S. Addison
  • Publication number: 20220104738
    Abstract: An ongoing pain detection system and method are provided. The method includes obtaining imaging data from patient using functional near-infrared spectroscopy from at least one cortical region of the brain of a non-responsive patient and observing power spectral density variations in the signal. The measured imaging data is compared with patient pain based on control data to recognize ongoing pain in the non-responsive patient.
    Type: Application
    Filed: September 11, 2019
    Publication date: April 7, 2022
    Inventors: David Borsook, Ke Peng
  • Publication number: 20220104739
    Abstract: Methods and systems for measuring hemoglobin concentration (cHb). A retinal tissue having blood vessels is illuminated by light including two isosbestic wavelengths (?1,?2). The isosbestic wavelengths(?1,?2) correspond to isosbestic points where oxy- and deoxyhemoglobin (HbIO2,Hb) have the same molar extinction coefficient. Measurements are collected of a plurality of backscattered reflection intensities (I(?b,?1), I(xt,?1), I(?b,?2), I(xx,X2)). Preferably, the measurements are spectrally resolved at least for the two isosbestic wavelengths (?1,?2) and position-resolved for at least a blood vessel location (xb) coinciding with a selected blood vessel and a tissue location (xt) coinciding with the retinal tissue without blood vessel. The hemoglobin concentration (cHb) can be calculated based on a combination of the measurements at the two isosbestic wavelengths (?t,?2).
    Type: Application
    Filed: January 23, 2020
    Publication date: April 7, 2022
    Inventors: Arjen AMELINK, Mathivanan DAMODARAN, Johannes Fitzgerald DE BOER
  • Publication number: 20220104740
    Abstract: A hemodialysis patient data acquisition and management system resides on a host computer which receives information from one or more non-invasive, optical blood monitors associated with a hemodialysis system. When a patient is undergoing hemodialysis treatment, a sensor assembly monitors the patient's blood flowing through the hemodialysis system and a controller for the blood monitor generates data which includes at least an identification code for the patient undergoing the treatment on the respective system, and non-invasively determined blood data taken at the onset of the scheduled treatment, such as initial Hgb, HCT, and SAT values. A host computer communicates with the one or more optical blood monitors, preferably via a wireless network, and the patient's session commencement data is downloaded to the host computer.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 7, 2022
    Inventors: Louis LeeGrande Barrett, David W. Peterson, Brian H. Nathanson, Michael J. Germain, Michael K. Black
  • Publication number: 20220104741
    Abstract: A syringe assembly includes (i) a syringe with a cylindrical body, luer tip at a first end, finger grip at a second end and a cannula extending from the luer tip into the cylindrical body, and (ii) a plunger unit having an adapter portion, receiving cavity, finger grip and piston. A channel extends the length of the adapter portion to receive the cannula in one end and a variety of connectors, valves and/or syringes in a second end. The end of the channel accessible in the receiving cavity mates with or engages any number of commercially available valves, connectors and/or syringes while the luer tip similarly connects to any number of valves, catheters, connectors, etc., depending on the task being undertaken with the syringe assembly.
    Type: Application
    Filed: December 8, 2020
    Publication date: April 7, 2022
    Inventors: Michael Brewer, Robert Fortune, Bill Phillips
  • Publication number: 20220104742
    Abstract: An automatically locking safety device, e.g., for use in a blood collection procedure, can include a housing, first and second needle covers that are at least partly received in the housing, and a needle that is at least partly received in at least one of the first and second needle covers. The needle can include a proximal tip configured for placement into a patient and a distal tip configured for placement into a blood collection vial. In some embodiments, the first and second needle covers are biased by a biasing member. In some cases, one or both of the first and second needle covers can be locked to prevent axial movement thereof after the blood collection procedure. In certain embodiments, a distal end of the device is configured to connect with a medical connector, such as a needleless IV access device.
    Type: Application
    Filed: September 13, 2021
    Publication date: April 7, 2022
    Inventors: David P. Allen, Edward P. Browka, Jessie Delgado, Matthew R. Penny, David L. Foshee, Theodore J. Mosler
  • Publication number: 20220104743
    Abstract: A condition estimation device calculates different types of index values using biological information of the user, and estimates the relax level of the user using relax levels set according to change tendencies of the index values. As the index values, at least two of a heart rate of the user, an ? wave time content ratio indicating a ratio of a time period during which an ? wave of the user is generated to a unit time period, and an integrated value of high frequency components of the heart rate of the user by performing a frequency analysis to a change in the heart rate of the user are calculated. The relax level of the user is estimated using the relax levels set according to the change tendencies of the calculated index values.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Inventor: Yumi SHIBAGAKI
  • Publication number: 20220104744
    Abstract: An evaluation device includes a display unit; a point-of-gaze detector configured to detect a position of a point of gaze of a subject on the display unit; a display controller configured to display, on the display unit, an image containing an induction area that tends to induce visual hallucinations in the subject; a determination unit configured to, based on position data on the point of gaze, determine whether the point of gaze is staying; an area detector configured to, when the determination unit determines that the point of gaze is staying, calculate an area of staying in which the point of gaze is staying in the display unit; an acquisition unit configured to acquire a feature value representing a state of display of the area of staying that is calculated by the area setting unit; and an evaluation unit.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Inventor: Katsuyuki Shudo
  • Publication number: 20220104745
    Abstract: A worry stone system is provided. The system includes a worry stone device having an internal sensing and processing system, a user computing device, and a server having a memory storing worry stone data. The server may be programmed to receive worry stone data from the worry stone device through the user computing device in near real-time that includes contact time between the user and the worry stone device, a rate of rubbing the worry stone device, and/or a pressure used for rubbing the worry stone device. The server may process the worry stone data and send the same for display on the user computing device. The server operates to continuously process received near real-time worry stone data and send the processed worry stone data for display on the user computing device during the entire time of engagement of the worry stone device by the user.
    Type: Application
    Filed: March 15, 2021
    Publication date: April 7, 2022
    Inventor: Charles Isgar
  • Publication number: 20220104746
    Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the motor function of a subject having a muscular disability, in particular SMA by active testing of the subject.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian GOSSENS, Michael LINDEMANN, Florian LIPSMEIER, Detlef WOLF
  • Publication number: 20220104747
    Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the distal hypotonia of a subject having a muscular disability, in particular SMA by active testing of the subject.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian GOSSENS, Michael LINDEMANN, Florian LIPSMEIER, Detlef WOLF
  • Publication number: 20220104748
    Abstract: The present disclosure relates to a microneedle array for bio-sensing or a biosensor using the microneedle array. The microneedle array for bio-sensing does not include an additional electrode or an additional conductive coating, have a solid structure, and is homogeneous throughout the solid structure. The microneedle array for bio-sensing is composed of a material including poly (3,4-ethylendeddioxythiophene):poly (styrenesulfonate) (PEDOT:PSS).
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: RAPHAS CO., LTD.
    Inventors: Keun Ho LEE, Eun Jin AN, Jung Hyun BAE, Jung Dong KIM, Do Hyeon JEONG
  • Publication number: 20220104749
    Abstract: Systems and methods for cardiac fast firing (e.g., atrial fast firing) detection perform frequency analysis on channels of collected cardiac waveform data and test the data for outlier frequency complex content that is of higher frequency than baseline frequency complex content associated with cardiac fibrillation (e.g., atrial fibrillation) or other arrhythmogenic activity. Anatomical regions from whence the cardiac fast firing originates can be displayed in real time on an epicardial surface map via a graphical display, aiding administration of therapy. Prior to such detection, QRST complex removal can be performed to ensure that ventricular activity does not infect the atrial fast firing analysis. A frequency-based method for QRST complex removal is also disclosed.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Inventors: PING JIA, QINGGUO ZENG, TIMOTHY G. LASKE, QING LOU
  • Publication number: 20220104750
    Abstract: Systems and methods are provided for analyzing electrocardiogram (ECG) data of a patient using a substantial amount of ECG data. The systems receive ECG data from a sensing device positioned on a patient such as one or more ECG leads. The system may include an application that communicates with an ECG platform running on a server(s) that processes and analyzes the ECG data, e.g., using neural networks for delineation of the cardiac signal and classification of various abnormalities, conditions and/or descriptors. The processed ECG data is communicated from the server(s) for display in a user-friendly and interactive manner with enhanced accuracy.
    Type: Application
    Filed: October 18, 2021
    Publication date: April 7, 2022
    Applicant: Cardiologs Technologies SAS
    Inventors: Jia LI, Romain POMIER, Chiara SCABELLONE, Cyril GAUDEFROY, Benjamin BARRE, Julien FONTANARAVA, Christophe GARDELLA, Mathieu SORNAY, Thomas BORDIER
  • Publication number: 20220104751
    Abstract: A computer-implemented method for determining and/or monitoring a level of modified state of consciousness of a subject receiving a treatment session comprising modifying the state of consciousness of the subject non-pharmacologically, the method comprising the steps of: receiving response data representing a subject's response to the treatment session, wherein the response data comprises measured data comprising electroencephalogram, BEG, data, the EEG data comprising: data collected from at least one of: at least one frontal (F) EEG electrode located on the scalp anatomical region corresponding to a frontal lobe of the subject, and at least one parietal (P) EEG electrode located on the scalp anatomical region corresponding to a parietal lobe of the subject, determining from the response data, the level of modified state of consciousness of a subject of the subject.
    Type: Application
    Filed: February 7, 2020
    Publication date: April 7, 2022
    Applicant: ONCOMFORT SA
    Inventors: Diane Jooris, Mario Huyghe, Clémence Toussaint
  • Publication number: 20220104752
    Abstract: According to an embodiment of the present application, as a method of determining whether to output an alert of a user's thyroid dysfunction, there may be provided a thyroid dysfunction monitoring method including receiving a user's medication information from an external device; selecting a monitoring algorithm to be used to determine whether to output the alert on the basis of the medication information; and determining whether to output the alert on the basis of the selected monitoring algorithm.
    Type: Application
    Filed: October 29, 2021
    Publication date: April 7, 2022
    Inventor: Jae Hoon MOON
  • Publication number: 20220104753
    Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the axial motor function of a subject having a muscular disability, in particular SMA by active testing of the subject.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian GOSSENS, Michael LINDEMANN, Florian LIPSMEIER, Detlef WOLF
  • Publication number: 20220104754
    Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the axial motor function of a subject having a muscular disability, in particular SMA by active testing of the subject.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian GOSSENS, Michael LINDEMANN, Florian LIPSMEIER, Detlef WOLF
  • Publication number: 20220104755
    Abstract: Aspects described herein relate to the field of disease tracking and diagnostics. Specifically, they relate to a method of assessing a muscular disability and, in particular, spinal muscular atrophy (SMA) in a subject comprising the steps of determining at least one parameter from a dataset of sensor measurements of the subject using a mobile device, and comparing the determined at least one parameter to a reference, whereby the muscular disability and, in particular, SMA will be assessed. Aspects described herein also relate to a mobile device comprising a processor, at least one pressure sensor and a database as well as software which is tangibly embedded to said device and, when running on said device, carries out the method of the invention as well as the use of such a device for assessing a muscular disability and, in particular, SMA.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian GOSSENS, Michael LINDEMANN, Florian LIPSMEIER, Detlef WOLF
  • Publication number: 20220104756
    Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the axial motor function of a subject having a muscular disability, in particular SMA by active testing of the subject.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian GOSSENS, Michael LINDEMANN, Florian LIPSMEIER, Detlef WOLF
  • Publication number: 20220104757
    Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the lung volume of a subject having a muscular disability, in particular SMA by active testing of the subject.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian GOSSENS, Michael LINDEMANN, Florian LIPSMEIER, Detlef WOLF
  • Publication number: 20220104758
    Abstract: A device and method for sleep monitoring, in particular to a device and method for determining time-to-sleep and wake periods during sleep and to a device and method for determining rapid eye movement (REM) sleep and non REM (NREM) sleep. The method for determining time-to-sleep and wake periods during sleep comprising the steps of obtaining motion data representative of motion of a user; detecting the time-to-sleep from the motion data based on a first time-above-threshold (TAT) threshold and a first proportional integration method (PIM) threshold; and detecting the wake periods during sleep from the motion data based on a second TAT threshold and a second PIM threshold.
    Type: Application
    Filed: October 22, 2021
    Publication date: April 7, 2022
    Inventors: Khine Cho Cho Thein, William Tan, Kittipong Kasamsook
  • Publication number: 20220104759
    Abstract: The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general anesthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.
    Type: Application
    Filed: August 16, 2021
    Publication date: April 7, 2022
    Inventors: Emery N. Brown, Ken Solt, Joseph F. Cotten, Jessica J. Chemali, Frederick M. Debros
  • Publication number: 20220104760
    Abstract: A method for determining a representation for a level of pain experienced by a patient, the method comprising: providing reference information concerning at least two visible features that are indicative of experienced pain; capturing information indicative of facial features by observing the patient directly or indirectly over a predetermined time period; allocating at least one pain indicator corresponding to each feature based on the captured information; and collating each indicator to construct the pain level indicator.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Inventor: Philip Anastasis Daffas
  • Publication number: 20220104761
    Abstract: In general, techniques are described for automatic disablement of alerts for diabetic conditions. A device including a memory and a processor may be configured to perform the techniques. The memory may store alert data. The processor may obtain projected levels of glucose in a patient over a time frame, and determine whether the projected levels of glucose leave a prescribed range. The processor may generate, when the projected levels of glucose in the patient leave the prescribed range during the time frame and based on the alert data, a graphical alert indicating that the projected levels of glucose will leave the prescribed range. The processor may further determine that a maintenance event alters the projected levels of glucose, and disable, without user input and based on the determination that the maintenance event alters the projected levels of glucose, the graphical alert for a temporary period of time.
    Type: Application
    Filed: September 22, 2021
    Publication date: April 7, 2022
    Inventors: Yuxiang Zhong, Pratik J. Agrawal, Chantal M. McMahon, Dae Kang, David Legray, Nicole T. Robinson, Natassia Mattoon, Michael A. Hill
  • Publication number: 20220104762
    Abstract: Systems, devices, and methods for performing precise treatment, mapping, and/or testing of tissues are disclosed. Systems, devices, and methods for administering an agent to one or more a precise regions within a tissue mass are disclosed. Systems, devices, and methods for treating targeted regions within a tissue mass are disclosed. Systems, devices, and methods for identifying, localizing, monitoring neural traffic in the vicinity of, quantifying neural traffic in the vicinity of, and mapping neural traffic near targeted regions within a tissue mass are disclosed.
    Type: Application
    Filed: October 14, 2021
    Publication date: April 7, 2022
    Inventors: Landy Toth, Robert Schwartz
  • Publication number: 20220104763
    Abstract: This disclosure relates generally to method and system for determining myocardial ischemia severity based on hemodynamic parameters estimation. Many patients suffer from myocardial ischemia due to narrowing of coronary artery resulting poor oxygen supply in cardiac muscles. The method includes receiving Electrophysiology (EP) signal from a simulated heart surface model to generate a single lead ECG template. The method further estimates hemodynamic parameters using a hemodynamic module based on the single lead ECG template and then estimates cardiac pressure-volume loop variables. The myocardial ischemia severity of the heart surface model is determined which includes one of moderate ischemia, severe ischemia and silent ischemia. Here, the cardiac source module is coupled with the hemodynamic module to determine cardiac transmembrane potential (TMP) of the heart surface model through contractility function.
    Type: Application
    Filed: August 17, 2021
    Publication date: April 7, 2022
    Applicant: Tata Consultancy Services Limited
    Inventors: OISHEE MAZUMDER, DIBYENDU ROY, ANIRUDDHA SINHA
  • Publication number: 20220104764
    Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the distal motor function of a subject having a muscular disability, in particular SMA by active testing of the subj ect.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian GOSSENS, Michael LINDEMANN, Florian LIPSMEIER, Detlef WOLF
  • Publication number: 20220104765
    Abstract: A surgical visualization system may include particle trend analysis. The surgical visualization system may include a field programable gate array (FPGA) that is configured to transform sensor information of backscattered laser light into real-time information of particle movement (e.g., blood cells) in a portion of a surgical field. The system may communicate the real-time information to a processor that is remote to the FPGA for aggregation and analysis. The surgical visualization system may display both a metric representing a present state of moving particles and an aggregated state of the moving particles. The system may display both the rate of particle movement and the acceleration for use by the surgeon.
    Type: Application
    Filed: October 2, 2020
    Publication date: April 7, 2022
    Applicant: ETHICON LLC
    Inventors: Frederick E. Shelton, IV, Jason L. Harris
  • Publication number: 20220104766
    Abstract: An apparatus and a method of monitoring fat burning in a subject non-invasively by measuring capacitance of the skin is described. In some embodiments, capacitance is measured at one or more skin depths for measuring acetone concentration and/or production as an indicator of fat burning or ketosis.
    Type: Application
    Filed: June 18, 2020
    Publication date: April 7, 2022
    Inventor: Geoffrey Locke Taylor
  • Publication number: 20220104767
    Abstract: An intraoral biological monitoring device includes a sensor, a communication unit that is configured to perform communication in response to an operation in which a signal is input to the sensor, and a mouthpiece that holds the sensor and the communication unit, and is attached to a crown of a subject to cover at least a part of a gum of the subject.
    Type: Application
    Filed: January 24, 2020
    Publication date: April 7, 2022
    Inventors: Ryosuke ISOGAI, Yoshifumi YOSHIDA, Kotaro MAKI
  • Publication number: 20220104768
    Abstract: Instrumented mouthguards include components such as accelerometer modules that enable monitoring of head movements of a mouthguard wearer. Various embodiments that provide instrumented mouthguard devices and components configured for use in instrumented mouthguard devices, including flexible circuit board substrates. In some embodiments, the flexible circuit board substrate is configured to allow sizing irregularities resultant from customization of the mouthguard body to a specific wearer.
    Type: Application
    Filed: February 5, 2020
    Publication date: April 7, 2022
    Inventors: Michael Vegar, Ben Nizette, Lucas Lang, David Austin
  • Publication number: 20220104769
    Abstract: A biological information monitoring system includes: a biological information monitoring apparatus that monitors biological information of an organism wearing the biological information monitoring apparatus on an ear; and a charger that charges the biological information monitoring apparatus in a non-contact manner. The charger charges the biological information monitoring apparatus when the biological information monitoring apparatus is not monitoring biological information.
    Type: Application
    Filed: December 23, 2020
    Publication date: April 7, 2022
    Applicant: Agama-X Co., Ltd.
    Inventors: Motofumi BABA, Masahiro SATO, Kiichiro ARIKAWA, Tadashi SUTO, Kengo TOKUCHI
  • Publication number: 20220104770
    Abstract: A circuit system includes a user interface, voltage source, and a terminal bank connected to the voltage source. The circuit can be used in a powered catheter system where the catheter includes a structural reinforcement layer such as a braid comprised of one or more wires. The reinforcement layer can be used to convey a current or signal in a powered catheter. The catheter may utilize a hypotube element which provides integrated sensors in order to power and control multiple systems in the powered catheter.
    Type: Application
    Filed: December 14, 2021
    Publication date: April 7, 2022
    Applicant: MicroVention, Inc.
    Inventor: Heath Bowman
  • Publication number: 20220104771
    Abstract: An automated health check device and methods, the device comprising: at least one imaging sensor configured for capturing at least one image of at least an area confined by a window of the vehicle; at least one vital signs sensor configured for measuring a health parameter of a passenger at the area confined by the window; and at least one processor configured for: acquiring and analyzing the at least one image to determine location of the window; determining based on the determined location of the window a location of the passenger; determining the at least one vital signs sensor being oriented to a predetermined point of view in relation to the location of the passenger determined; and obtaining a measurement of the health parameter of the passenger from the at least one vital signs sensor.
    Type: Application
    Filed: October 6, 2020
    Publication date: April 7, 2022
    Applicant: NEC Corporation Of America
    Inventors: Tsvi LEV, Yaacov HOCH