Abstract: Provided is a liquid drug permeation system (100) for causing permeation of a liquid drug under an endoscope (10), including: a liquid drug permeation apparatus (20); and an assisting device (30) configured to assist position adjustment of the liquid drug permeation apparatus (20) under the endoscope (10). When a connector portion (32) of the assisting device (30) is mounted on the endoscope (10) and an inner tube (21) is fixed to the assisting device (30) with a fixture (33), an outer tube (22) of the liquid drug permeation apparatus (20) is allowed to selectively advance and retract with respect to the inner tube (21), and a water-absorbing material (23) mounted on a distal end of the inner tube (21) is allowed to be pulled into the outer tube (22) by advancing the outer tube (22) with respect the inner tube (21).

Abstract: Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitation mechanism disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.

Abstract: An intrathecal drug delivery system configured to monitor one or more physiological conditions of the patient to look for opportunities to time medicament delivery to coincide with patient activity inferring heightened cerebrospinal fluid oscillations, thereby improving dispersion of the medicament within the intrathecal space of the patient. The intrathecal drug delivery system includes an implantable medical pump, one or more physiological sensors, and an external programmer configured to program the implantable medical pump with a treatment protocol specifying at least one period of time during which a specified quantity of medicament is to be administered during which the implantable medical pump utilizes data from the one or more physiological sensors to time delivery of the medicament.

Abstract: An array of differing microneedles can be accurately achieved including a film having first and second, outwardly facing major surfaces. The first, outwardly facing major surface has a plurality of stratum corneum piercing microneedles extending therefrom, and the plurality of microneedles includes a plurality of first microneedles having a first benefit agent and a plurality of second microneedles having a second benefit agent.

Abstract: The present invention relates a device (10) for applying a tattoo or a permanent make-up or a similar skin treatment. The device has a grip portion (11) containing a drive unit, and a disposable needle-holder cartridge (13) which can be coupled to the grip portion (11). The needle-holder cartridge (13) comprises an attachment part (20) for attachment to the grip portion (11), a needle-holder head (28) with a stem (30) which partially protrudes from the attachment part (20), a needle supported by the needle-holder head (28), a tip (25) having a needle-guide nozzle (27). The needle-holder head (28) is arranged in the needle-holder cartridge (13) for a linear movement along the axial direction of the needle-holder cartridge (13), in order to cause the oscillation of the end of the needle in and out of the tip (25) of the needle-holder cartridge (13).

Abstract: A vascular access device including a catheter adapter, a port opening, and an elastomeric valve. The catheter adapter extends along a longitudinal axis and includes a proximal end, a distal end, and a lumen extending therebetween. The port opening is formed in a surface of the catheter adapter in fluid communication with a side port of the catheter adapter and the lumen. A structural geometry of the port opening directs a fluid into the lumen in a proximal direction. The elastomeric port valve is disposed within the lumen and configured to deform in response to a transverse force applied thereto. A proximal gap may result between the inner wall forming the lumen and a proximal side of the elastomeric port valve, thereby opening a fluid path.

Abstract: This present disclosure provides devices, systems, and methods relating to the management of a subject's medical needs involving safely accessing a body cavity. In particular, the present disclosure is directed to body cavity conduit devices and systems that facilitate repeated access to a subject's body cavity for removing fluid or performing a procedure in a manner that provides enhanced comfort, safety, and efficacy.

Abstract: A hemostatic valve extension is provided that allows a clinician to perform interventional procedures from any location around the patient rather than being limited to a particular side, often the right side. The extension provides for a hemostatic connector, flexible tube, and a replacement hemostatic valve that allows the original hemostatic valve, which can be, for example, part of an introducer sheath, to be bypassed and the replacement hemostatic valve to be used to perform the medical procedure from a desired location of the clinician. The extension can include a distal end connecting element that is configured to be used with a plurality of hemostatic valve types such that the connector can be used with different sized hemostatic valves without having to swap parts or components on the connector.

Abstract: A device to assist the performance of a heart with at least one pump that is formed as a rotary pump and driven via a magneto coupling.

Abstract: A device to assist the performance of a heart with at least one pump that is formed as a rotary pump and driven via a magneto coupling.

Abstract: A pump system is provided for pumping a fluid and a method is provided for operating the pump system. The pump system comprises a first diaphragm fluid pump, a first inlet cannula connected to the first diaphragm fluid pump for supplying a fluid to the first diaphragm fluid pump, a first outlet cannula connected to the first diaphragm fluid pump for discharging the fluid out of the first diaphragm fluid pump, and a first service pump, which is connected via a first pressure line to the first diaphragm fluid pump and is confirmed to drive the first diaphragm fluid pump via the first pressure line. The pump system further comprises a first inlet flow sensor for detecting a first inlet flow of the fluid in the first inlet cannula and/or a first outlet flow sensor for detecting a first outlet flow of the fluid in the first outlet cannula.

Abstract: Systems and related methods for supplying power to an implantable blood pump are provided. A system includes a base module and a plurality of energy storage devices. A first energy storage device is operatively coupled to the base module. A second energy storage device is operatively coupled to the first modular energy storage device. The energy storage devices are mechanically coupled in series, electrically coupled in parallel, and configured to provide redundant sources of power to drive an implantable blood pump.

Abstract: Disclosed is an iontophoresis-based patch type skin care device for allowing a functional substance for skin care to be effectively absorbed into a user's skin by causing iontophoresis on the user's skin through a conductive patch. The iontophoresis-based patch type skin care device for allowing the functional substance for the skin care to be absorbed into the user's skin by the iontophoresis includes a skin care device body that generates power to cause the iontophoresis. The skin care device body includes a power circuit that is provided in an interior space of a body and that includes a power unit that generates the power for the iontophoresis and one or more electrodes to which the power is applied, and a bridge that is provided so as to be combinable with the body and that receives the power through the one or more electrodes.

Abstract: The present disclosure generally relates to a system for treating headaches and other pain associated with the occipital nerves. More particularly, the disclosure relates to a system of treating pain by selectively activating specific nerve fibers with a single, fault-resistant contact situated proximate to, but not in direct contact with, portions of one or more the occipital nerves. Additional measures ensure the lead does not migrate or fracture, resulting in long-lasting pain relief.

Abstract: The present invention provides a lead template for optimal lead placement and spacing during a surgical method and procedure for implantation of a neuromodulation system at a spinal treatment site.

Abstract: A system and/or method involving sensing first data via at least one implantable sensor of an implantable medical device (IMD) system, and identifying a presence-absence state of a magnetic resonance imaging (MRI) system using the first data.

Abstract: A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.

Abstract: The present disclosure provides a neuromodulation medical treatment device and a medical treatment neuromodulation method for stimulating peripheral nerves. The device comprises a pulse generator and at least one active electrode connected to the pulse generator. The at least one active electrode has an electrically conductive surface of less than or equal to 0.3100 square inch and the electrically conductive surface is attachable to a patient's skin in a proximity of branches of peripheral nerves. The at least one active electrode is adapted to stimulate via the electrically conductive surface the peripheral nerves by electrical pulses generated by the pulse generator. The control unit controls the pulse generator and sets at least one parameter of generated electrical pulses.

Abstract: A swallowing medical device includes: an attachment unit configured to be attached to a target portion of a human body for a medical operation; a control unit configured to control the medical operation; and a storage configured to store use information regarding a use state over time of the attachment unit. The control unit executes a control for restricting use of the attachment unit on the basis of a fact that the use information does not satisfy a set condition for ensuring a characteristic of the attachment unit.

Abstract: Method for calibrating a nerve stimulation device comprising (a) providing the user with an initial stimulus at a sub-sensory level and obtaining feedback regarding whether the stimulus is felt; (b) if it is not felt, increasing the stimulation level by a first level variation and again obtaining feedback; (c) repeating the previous step until feeling the stimulus is reported; (d) reducing stimulus by the initial level variation; (e) repeating the process from the previously established level while using a second level variation is used which is smaller than the first level variation; (f) once stimulus feeling is reported, the level is again reduced by the second level variation; (g) this level, achieved after the second “crossing” of the threshold, can be used as the sensory threshold value; (h) additional calibration rounds can be conducted using ever-lower level variations for each subsequent round to more accurately the sensory threshold is determined.

Abstract: The invention pertains to the restriction of movement of one or two cochlear implant processors affixed inside of a decorative hairbow. The functionality of a concealed pocket within the hairbow is to limit the movement of a cochlear implant processor while concealing the presence of the processor. Concealed pockets are located bilaterally on the hairbow to provide users with either a unilateral or bilateral wearing option. The hairbow is affixed to a retainment item that can be attached to the user's hair or head. Due to the decorative nature of the hairbow, young cochlear implant users may be more inclined to wear the cochlear device.

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

Abstract: A device and algorithm for controlling an autonomic function in an individual. A controller device that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure. A control interface and algorithm for controlling an autonomic function in a subject. For instance, an algorithm that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure.

Abstract: The disclosure describes an implementation of a combinational thermometric-R2R that includes a thermometric DAC circuit to output the coarse output steps, an R2R circuit to control the fine output steps, and a resistor in series with the thermometric and R2R circuits. The techniques of this disclosure implement a fine resolution DAC, on the order of two nanoamps per bit, that operates at low current, yet maintains monotonicity throughout the DAC output range.

Abstract: Devices, systems, and techniques are described for selecting an evoked compound action potential (ECAP) growth curve based on a posture of a patient. The ECAP growth curve defines a relationship between a parameter defining delivery of stimulation pulses delivered to the patient and a parameter of an ECAP signal of a nerve of a patient elicited by a stimulation pulse. In one example, a medical device detects a posture of a patient and selects an ECAP growth curve corresponding to the detected posture. The medical device selects, based on the ECAP growth curve corresponding to the detected posture and a characteristic of a detected ECAP signal, a value for a parameter for defining delivery of the stimulation pulses to the patient and controls delivery of the stimulation pulses according to the selected value for the parameter.

Abstract: Techniques are disclosed for using a cardiac signal sensed via a plurality of electrodes disposed on one or more leads implanted within an epidural space of a patient to control spinal cord stimulation (SCS) therapy. In one example, an implantable medical device (IMD) senses an electrical signal via a plurality of electrodes disposed on one or more leads implanted within an epidural space of a patient. Processing circuitry determines, from the electrical signal, one or more cardiac features indicative of activity of a heart of the patient. The processing circuitry controls, based on the one or more cardiac features, delivery of SCS therapy to the patient.

Abstract: Embodiments may provide the capability to provide brain monitoring and stimulation devices using parameter sets that are automatically refined during operation. For example, in an embodiment, a system may comprise a plurality of stimulation devices connected to signal output circuitry interfacing the processor with the stimulation devices, so that the processor generates and transmits stimulation signals to the stimulation devices, and a plurality of sensing devices connected to signal input circuitry interfacing the processor with the sensing devices, so that the processor receives sensed signals from the sensing devices, wherein the program instructions and data stored in the memory are further configured so that the processor performs dynamic closed loop feedback of the stimulation signals based on the received sensed signals to provide self-guided, self-directed diagnostics and treatment of neural conditions using at least one recipe for a treatment strategy guided by artificial intelligence.

Abstract: The present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for evaluating the efficacy of neuromodulation therapy using evoked potential (EPs). The systems and methods disclosed herein facilitate the evaluation of both parameter-dependent and system-dependent changes in EPs as indicators of therapeutic efficacy.

Abstract: The present disclosure relates to a medical system, comprising at least an implantable medical device, and a multi-axis accelerometer comprised by the implantable medical device for measuring an acceleration of the implantable medical device along a plurality of vectors, wherein the multi-axis accelerometer is configured to provide for each vector a signal indicative of the acceleration of the implantable medical device in the direction of the respective vector. The medical system is configured to assess said signals to automatically select or propose a vector of said plurality of vectors that comprises the best alignment with a pre-defined vector.

Abstract: Systems and methods for monitoring and treating patients with heart failure are discussed. The system can store in a memory stimulation parameters, including stimulation timing parameters for a plurality of heart rate ranges. The system includes a plurality of timers with respective durations for the plurality of heart rate ranges. A stimulation control circuit can identify a target heart range in which a detected heart rate falls, and measure an atrioventricular (AV) conduction characteristic value in response to the timer for the target heart range being expired at the detected heart rate. The stimulation control circuit can update a stimulation parameter corresponding to the target heart rate range using the measured AV conduction characteristic. The updated stimulation parameter can be used in cardiac stimulation.

Abstract: VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.

Abstract: Ventricle-from-atrium (VfA) cardiac therapy may utilize a tissue-piercing electrode implanted in the left ventricular myocardium of the patient's heart from the right atrium through the right atrial endocardium and central fibrous body. The exemplary devices and methods may determine whether the tissue-piercing electrode is achieving effective left ventricular capture. Additionally, one or more pacing parameters, or paced settings, may be adjusted in view of the effective left ventricular capture determination.

Abstract: Embodiments of the present disclosure relate to implantable medical device (IMD) enclosures. In an exemplary embodiment, an IMD comprises: a housing comprising an open end and a header defining a cavity and comprising at least one conduit through a wall of the header, wherein the header is formed from a non-conductive material. Further, the IMD comprises a coupling member comprising a flange, wherein the flange is configured to be received by the open end of the housing and wherein the flange and the open end of the housing at least partially overlap along an axial direction of the IMD when the flange is received by the open end. Additionally, the IMD comprises an electrode arranged on an outer surface of the header and a feedthrough coupled to the electrode and extending through the conduit of the header, wherein the feedthrough is configured to be coupled to internal circuitry housed within the IMD. Further, the IMD comprises a ring forming a hermetic seal between the coupling member and the header.

Abstract: The disclosure describes various aspects of an automated external defibrillator (AED) system, including shock generating electronics, a battery configured for providing power to the shock generating electronics, power management circuitry configured for managing the shock generating electronics and the battery, at least one environmental sensor configured for monitoring environmental conditions in which the AED system is placed, and a controller configured for controlling the power management circuitry and the at least one environmental sensor. The at least one environmental sensor includes a temperature sensor configured for providing a temperature measurement, and the controller is further configured for adjusting operations of the power management circuitry in accordance with the temperature measurement provided by the temperature sensor. The disclosure further describes associated methods of using the AED system.

Abstract: Wearable, automatic external, and implantable defibrillators, as well as methods of operation in such systems, are disclosed with shock delivery mitigations to avoid delivering a defibrillation shock on a T-wave. Prior to issuance of a defibrillation shock, one or more detected cardiac events are analyzed to characterize a detected event that is sensed for purposes of synchronizing the defibrillation shock. The detected event can be characterized as an R-wave or a T-wave, and the shock delivery protocol is then selected based on the characterization of the detected event to avoid shock-on-T and potential pro-arrhythmia.

Abstract: The present invention relates to a method for producing a nitrogen-based non-thermal atmospheric pressure plasma for treating damaged muscles or promoting regeneration of damaged muscles, and to a method for treating damaged muscle or promoting regeneration of damaged muscles using the atmospheric pressure plasma. The nitrogen-based non-thermal atmospheric pressure plasma according to the present invention can effectively induce muscle cell activation, migration of muscle cells to damaged sites, muscle cell proliferation, and muscle cell differentiation, without surgical operation or during a treatment procedure after surgical operation, and thus can be advantageously used as a novel therapeutic agent and therapeutic method against muscle damage and muscle damage-associated diseases.

Abstract: A method of modulating a brain activity of a mammal is achieved by subjecting the mammal to transcranial magnetic stimulation (TMS) with a TMS apparatus at random variable pulse intervals for a time sufficient to modulate said brain activity. The method can also be used by administering electric stimulation to the brain. Improvement in a physiological condition or a clinical condition is achieved. Conditions to be treated include but are not limited to PTSD, autism spectrum disorder addiction (SUD) and Alzheimer's disease.

Abstract: A pulsed electromagnetic field (PEMF) device includes at least one electromagnetic (EM) field emitter. During post-birth recovery, a patient applies the EM field emitter to herself. The PEMF device performs a recovery cycle. In the recovery cycle, the EM field emitter emits EM fields having frequency combinations with a response frequency and a target frequency for a frequency combination period.

Abstract: There is a present unmet need for non-invasive therapeutic methods for administration to brain cancer subjects that would provide a robust attack against their primary or metastatic brain cancer. The present disclosure describes such methods to therapeutically induce regression and/or elimination of primary and metastatic brain cancers through Transcranial Electromagnetic Treatment (TEMT). The methods involve 1) enhancement of brain meningeal lymph flow to increase immune trafficking between the brain cancer and cervical lymph nodes, 2) rebalancing of immune or non-immune signaling within the brain, particularly from the brain tumor to the lymphatic system, and/or 3) direct attack on cells within and around the brain tumor itself. Thus, the above described TEMT methods could induce and boost a specific immune or non-immune response to a given brain tumor, as well as directly attack the brain tumor, to provide an effective therapeutic intervention against both primary and metastatic brain cancers.

Abstract: A light therapy device mounting system may include an elongate pole comprising a plurality of holes, a first portion, a second portion, and a coupler configured to couple the first portion and the second portion. In some embodiments, the system includes a slider mount slidably coupled to the elongate pole via at least one hole of the plurality of holes, a top bracket slidably coupled to the first portion of the elongate pole, and a bottom bracket slidably coupled to the second portion of the elongate pole. The top bracket may include a top hook for receiving a top portion of a door, and the bottom bracket may include a bottom hook for receiving a bottom portion of the door.

Abstract: An implantable vestibular prosthesis system includes an implantable optical array of optical sources configured for engagement with a disordered vestibular system to deliver optical stimulation signals to target stimulation locations within the bony or membranous labyrinth of the disordered vestibular system. An implantable stimulation processor is connected to the optical array and configured to produce the optical stimulation signals with the optical sources so as to generate directional pressure waves within the endolymphatic fluid directed to the target stimulation locations for vestibular perception by residual vestibular functioning.

Abstract: A device for delivering low-level electromagnetic radiation to a patient is provided herein. The device includes a support including a base surface that is substantially planar and configured to rest on a substrate. The support includes a contact surface opposite the base surface and contoured to support a curvature of a lumbar region and a sacral region of the patient in a supine position. The device also includes a first plurality of emitters coupled to the support proximate to the contact surface and configured to emit low-level electromagnetic radiation transdermally to at least one of the lumbar region and the sacral region.

Abstract: The invention relates to a glasses provided with a light source for illuminating at least a portion of the eye of a subject wearing the glasses and relates to a system comprising such a glasses. The invention further relates to a system comprising the glasses of the invention and further comprising an external device provided with a processor as well as a computer program which, in use, causes the processor to control the at least one light source in the glasses in accordance with a predetermined program, wherein preferably the desired program is chosen by a wearer of the glasses. The invention also relates to a glasses case. The invention also relates to the glasses of the invention for use in a method of treatment of Parkinson's Disease by phototherapy.

Abstract: Provided herein is a method of treating a traumatic brain injury in a subject in need thereof, the method including administering to the subject a therapeutically effective amount of radiation. The methods can improve motor function recovery and reverse motor function deficits after traumatic brain injury and/or ischemic stroke in a subject.

Abstract: Systems and methods are disclosed for predicting a resistance index associated with a tumor and surrounding tissue, comprising receiving one or more digital images of a pathology specimen, receiving additional information about a patient and/or a disease associated with the pathology specimen, determining at least one target region of the one or more digital images for analysis and removing a non-relevant region of the one or more digital images, applying a machine learning system to the one or more digital images to determine a resistance index for the target region of the one or more digital images, the machine learning system having been trained using a plurality of training images to predict the resistance index for the target region using a plurality of images of pathology specimens, and outputting the resistance index corresponding to the target region.

Abstract: The present invention discloses an intelligent life-saving system for a high-rise building and an electromechanical device for intelligent fast descent. The life-saving system includes a coverall with short-term high temperature resistance, cushioning and collision resistance, an oxygen-supplying helmet, a high-temperature resistant sling, and an electromechanical device for intelligent fast descent. The electromechanical device includes an intelligent detection and control device, a frame, a follow-up reel, a main shaft, and a fire-proofing and flame-retardant lifeline wound around the follow-up reel.

Abstract: A light-transmitting member includes a substrate including a resin layer, and a functional film disposed on the substrate. The substrate has a thickness of 1 ?m or more and less than 1 mm. An optical thickness of the functional film with respect to light having a wavelength of 464 nm or more and 653 nm or less is less than a half of the wavelength. A contact angle of water with respect to an upper surface of the functional film in the light-transmitting member is less than 90°. The functional film has a porous portion containing a plurality of particles. A first particle and a second particle among the plurality of particles are bound to each other with a binder. Each of the first particle, the second particle, and the binder contains an inorganic material.

Abstract: The present invention relates to face mask with a formed air duct, which makes it much easier for the user of the face mask to breathe. The facial layer of the face mask is provided with an extra piece. This support layer is located at the level of the chin of the skin and contacts the face layer in such a way that an air duct is created between the face layer and the support layer. Also, a filter can be fitted in this air duct.

Abstract: A personal air-purifying (PAP) mask includes a fan assembly; a plasma driven catalyst (PDC) assembly including an anti-microbial catalyst, wherein the anti-microbial catalyst is incorporated within a nanofiber layer of the PDC assembly; and a pre-filter, wherein the pre-filter also includes the anti-microbial catalyst incorporated therewith; wherein the PDC assembly is positioned between the fan assembly and the pre-filter, and wherein the fan assembly, the PDC assembly, and the pre-filter are within a main body of the PAP mask.

Abstract: The present invention provides a protective face mask having a two layer structure configured to have increased efficiency rate and longer filtration hours, while reducing resistance. In one embodiment, the protective mask of the present invention comprises layers treated with electret masterbatch.