Abstract: A speculum (10) includes a speculum sheath (12) formed with a first lumen (20) which is in fluid communication with a pump and controller unit (24) for introducing pressurized air into a vagina, a second lumen (26) in fluid communication with the pump and controller unit (24) for measuring air pressure in the vagina, and a third lumen (30) in which is disposed a viewing device (18).

Abstract: Systems and methods are disclosed for facilitating the evaluation of eye health and vision. The system is a mobile system and comprises at least one diagnostic device for performing a vision diagnostic test, the device being a VR headset; a portable computer communicatively coupled to the at least one diagnostic device, the computer having hardware adapted to guide a patient through the test, to compile test data, and to transmit the test data via a data connection; and a server in communication with the computer via the data connection, the server gathering the test data and presenting test data to a physician so that treatment may be provided to the patient. The at least one diagnostic device may include multiple portable, handheld diagnostic devices.

Abstract: A heterogeneous visual acuity chart and a visual acuity testing method and device are provided. The heterogeneous visual acuity chart is a size illusion chart composed of a heterogeneous reference zone and at least two types of optotypes of different sizes, where the heterogeneous reference zone is used to cause incorrect identification on the different types of optotypes of different sizes. The visual acuity testing method and device determine whether a visual acuity of a subject is true based on a difference between visual acuities tested with the heterogeneous visual acuity chart and a standard logarithmic visual acuity chart. The visual acuity chart is a size illusion chart composed of optotypes of different sizes and a perspective, which causes an illusion on a visual depth to interfere with the identification of the optotypes of different sizes.

Abstract: Aspect of this invention include methods for measuring the connection between neurosensory abnormalities and dry eye and for testing the efficacy of new and existing therapies of the treatment of Dry Eye in patients with symptoms of this or related conditions.

Abstract: An optical coherence tomography instrument suitable for imaging a retina is disclosed. In the instrument, an adjustable optical frequency shifter, which can be or include an acousto-optic modulator or electro-optic modulator, is arranged either (i) between a coupler and a reference optical system, (ii) in a reference optical system, (iii) between the coupler and a front-end optical system, or (iv) in a front-end optical system. The optical frequency of reference light or signal light may adjustably be increased or decreased. In operation, a subject is arranged such that its retina is in the focal depth of the front-end optical system. The increase or decrease in the optical frequency of the reference light or the sample light can be adjusted. Thereby, an interferogram representing a depth structure at the retina obtained between returning signal light and returning reference light may be brought to lie within a detection bandwidth of the instrument.

Abstract: Certain aspects of the present disclosure provide a system for processing image data from an intraoperative diagnostic device in real-time during an ophthalmic procedure. The system comprises an image capture element that captures a grayscale image of a first size and an image processing element that scales the grayscale image from the first size to a second size. The system also comprises a two-stage classification model comprising: a feature extraction stage to process the scaled grayscale image and generate a feature vector based on the scaled grayscale image and a classification stage to process the feature vector and generate an output vector. The image processing element is further configured to determine an image quality of the obtained grayscale image based on the output vector for display to an operator and the image quality of the obtained grayscale image indicates a probability that the obtained grayscale image includes an artifact.

Abstract: Systems and methods are disclosed for measuring pupillary light reflex and detecting diseases based on eyes features and trends in pupillary and other eye related features. In one example, disclosed is a system for evaluating pupillary features includes a device, a camera, a distance detector, a memory, and a control system. Image data corresponding to an eye of a user is received from the camera. Distance data associated with the eye of the user is received from the distance detector. The distance data is processed to determine a distance of the at least one eye of the user from the distance detector. The image data and the distance are processed to determine at least one pupillary feature. Based on the at least one pupillary feature, a health status associated with the user is determined.

Abstract: An ophthalmic device for observing a subject eye, including: a light source; a scanning section that scans light from the light source; and an objective optical system configured to form a pupil, which has a conjugate relationship with a pupil of the subject eye, at the scanning section, wherein the objective optical system has, in order from the scanning section toward the subject eye, a first lens group that is positive, a second lens group that is positive, and a third lens group that is disposed between the first lens group and the second lens group, and that includes a concave surface configured to diverge light.

Abstract: An additional floodlight projection device (10) based on an ophthalmic slit lamp and an ophthalmic image analysis system, comprising a slit lamp microscope examination instrument (20), the floodlight projection device (10), an image collection device (30), and an image analysis device (40).

Abstract: According to one embodiment, an intraocular pressure measurement system includes a pressure sensor implantable in an eye and comprising an optical cavity with an optical cavity depth that varies based on an intraocular pressure of the eye. The system further includes an external device for emitting light and measuring intraocular pressure based on reflected light. In an embodiment, the external device includes a light source configured to emit a plurality of beams, and a spectrometer configured to receive light reflected from at least two beams and produce an output based on the light reflected from the at least two beams. The output varies based on the depth of the optical cavity. The external device further includes a processor configured to receive the output and, based on the output, estimate the intraocular pressure of the eye.

Abstract: A device for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject includes a flexible lens that fits on the eye and changes curvature in response to a change in curvature of the eye. A microchannel disposed in or on the lens has one or more ends that are open to the atmosphere and an indicator solution is disposed in a portion of the 5 microchannel. The microchannel exhibits a change in volume in response to a change in curvature of the lens, which results in a change in position of the indicator solution in the microchannel. The change in position of the indicator solution in the microchannel is indicative of a change in IOP. The change in position of the indicator solution may be detected in digital images of the lens taken with a camera of a mobile electronic device such 0 as a smartphone or a camera worn by the subject.

Abstract: The present invention relates to a non-contact portable tonometry system and tonometry method using a difference in infrared intensity. A nozzle module receives compressed air from a compressed air supply source and sprays the same through an air spray port to a cornea of a subject, thus to cause corneal deformation. An infrared ray sensor is disposed in the nozzle module to emit infrared rays to the cornea and measure an amount of light reflected from the cornea. A controller converts the amount of light measured by the infrared ray sensor before and after the deformation of corneal into intraocular pressure.

Abstract: Systems and methods for real-time target validation during radiation treatment therapy based on real-time target displacement and radiation dosimetry measurements.

Abstract: An apparatus (100) and method (700, 800) for finding a range of lumen clearance, comprises: positioning (802) an imaging probe (160) in a lumen (170) such that the probe tip is positioned to irradiate a target area (172); acquiring a first set of images of an inside of the lumen while performing a non-flush pullback operation (S806) with the probe; analyzing the first set of images to determine a location of the probe tip with respect to a guide catheter; calculating a range of lumen clearance based on the location; and acquiring a second set of images of the inside of the lumen while performing a flush pullback operation only within the calculated range of lumen clearance. Calculating the range of lumen clearance includes calculating a pullback distance from the target area to the distal end of the guide catheter. The method further includes calculating a volume of contrast agent for clearing the calculated pullback distance.

Abstract: An imaging system for a patient comprises an imaging probe. The imaging probe comprises: an elongate shaft for insertion into the patient and comprising a proximal end, a distal portion, and a lumen extending between the proximal end and the distal portion; a rotatable optical core comprising a proximal end and a distal end, the rotatable optical core configured to optically and mechanically connect with an interface unit; a probe connector positioned on the elongate shaft proximal end and surrounding at least a portion of the rotatable optical core and an optical assembly positioned in the elongate shaft distal portion and proximate the rotatable optical core distal end, the optical assembly configured to direct light to tissue and collect reflected light from the tissue. A shear-thinning fluid can be provided between the elongate shaft and the rotatable optical core, such as to reduce undesired rotational variations of the rotatable optical core.

Abstract: A sensor module for blood pressure measurement includes: a substrate unit; and a first pressure sensor unit and a second pressure sensor unit coupled to the substrate unit, protruding by different distances from a reference plane of the substrate unit, and disposed adjacent to each other. Sensor module includes a control unit that controls operations of the first pressure sensor unit and the second pressure sensor unit, and measures a blood pressure in a blood pressure measurement target blood vessel based on a first pressure sensed by the first pressure sensor unit and a second pressure sensed by the second pressure sensor unit. There is a step between a reference plane of the first pressure sensor unit and a reference plane of the second pressure sensor unit.

Abstract: A method for evaluating cardiac diastolic function, which applies to the field of cardiac monitoring. The method comprises: obtaining vibration information of the surface of the thoracic cavity of a subject by means of one or more optical fiber sensors; preprocessing the vibration information to generate hemodynamic related information; performing high-frequency component extraction on the hemodynamic related information to generate high-frequency component information; determining a first feature value and a second feature value based on the hemodynamic related information and the high-frequency component information; generating indicating parameters based on the first feature value and the second feature value, and evaluating the cardiac diastolic function of the subject based on the indicating parameters.

Abstract: A mechanism for interpreting spatiotemporal data from augmented reality devices and virtual reality devices based on an analysis performed by one or more predictive machines. The predictive machines may implement machine learning techniques and/or algorithms to predict a heart rate for a user, from which user calorie expense can be calculated. In operation, a virtual reality or augmented reality device can receive positional data over time, for example derived from image data from a camera. The positional data can be averaged over time, and the averages can be rolled-up, and the averaged and rolled-up data can be fed into a predictive machine to generate a heart rate prediction. The heart rate prediction is used to generate a user heart rate, from which calories for the user's corresponding motion is determined.

Abstract: Methods and systems are provided for diagnosis and/or treatment of microvascular dysfunction, such as microvascular obstruction (MVO) by injecting volumetric flows into a vessel using an infusion system to arrest or reverse native antegrade flow, such that an equipoise value of volumetric flow rate and corresponding pressure may be determined, which in turn enables calculation of MVO, absolute hydrodynamic resistance, fractional flow reserve, coronary flow reserve, and other physiologic parameters in real-time or near real time.

Abstract: Apparatus and methods for diagnosing conditions consistent with the presence of cranial blood vessel blockage and large vessel occlusions (LVO's) using the framework of a small head-harness that is transportable, field-expedient, and durable. A single pulse set using ultrasonic or near-infrared energy is broadcast into a patient's brain allowing the apparatus to perform an area scan of the brain and detect and decipher cranial blood vessel blockage and LVO signal patterns. The interpretation of the pattern lies within the internal programming which produces a binary signal as to whether an LVO is suspected or not.

Abstract: A cardiac output measurement device according to at least one embodiment of the present disclosure includes a cardiac waveform measurement unit that measures a waveform of microwaves transmitted through a living body; a respiratory waveform measurement unit that measures a waveform during breathing or a waveform during apnea of the living body; and a cardiac output calculation unit that calculates a waveform for obtaining a cardiac output of the living body from the waveform of the microwaves by using the waveform during breathing or the waveform during apnea.

Abstract: As placement of a physiological monitoring sensor is typically at a sensor site located at an extremity of the body, the state of microcirculation, such as whether vessels are blocked or open, can have a significant effect on the readings at the sensor site. It is therefore desirable to provide a patient monitor and/or physiological monitoring sensor capable of distinguishing the microcirculation state of blood vessels. In some embodiments, the patient monitor and/or sensor provide a warning and/or compensates a measurement based on the microcirculation state. In some embodiments, a microcirculation determination process implementable by the patient monitor and/or sensor is used to determine the state of microcirculation of the patient.

Abstract: A method of measuring column interruption duration in a selected lower leg vein of a patient without undertaking dorsal foot measurements. The method includes the step of selecting a vein in the lower leg to be examined and selecting a valve in the vein to be observed. The valve's actions will be observed with Duplex ultrasound and timed. The method then effects calf muscle ejection and observing the action of the selected valve in the respective vein selected. The valve can be observed for opening or closing action, or action of blood flow (or lack of flow) through the valve. The CID is then determined calculated based on the timing of events observed with ultrasound. The ultrasound can be Duplex ultrasound; invasive measurements are not required.

Abstract: A system for measuring a pressure in a vein includes a needle sized and shaped to be inserted through a working channel of an endoscope. The needle is extending longitudinally and including a channel extending longitudinally therethrough. The system also includes a pressure sensing device including a longitudinally extending body sized and shaped to be slidably inserted through the channel of the needle and a sensor mounted on a distal portion of the body and connected to a proximal portion of the pressure sensing device via a connection cable. The sensor is configured to detect information corresponding to a pressure of a flow of blood through a vein.

Abstract: The present invention provides a sphygmomanometer that can create, before measuring a blood pressure, a state for making a blood pressure measurement accurate. A sphygmomanometer includes a fluid circuit and a control unit. The control unit has a first preparation processing unit, a second preparation processing unit, and a measurement processing unit which operate in a worn state of the sphygmomanometer. The first preparation processing unit operates a pressing cuff to discharge remaining fluid in a sensing cuff to the atmosphere through the fluid circuit. Then, the second preparation processing unit causes the sensing cuff to store a predetermined amount of pressure transmitting fluid received from a pump through the fluid circuit.

Abstract: Disclosed are a blood pressure measurement system for calculating a blood pressure value by using biometric signals measured at two different regions and a blood pressure measurement method using the same. The blood pressure measurement system includes a first sensor unit for detecting a hemorheological parameter at one region of a body; a second sensor unit for detecting a hemorheological parameter and arterial pressure at another region of the body; and a control unit including a blood pressure calculation unit for calculating a blood pressure value of a region at which a first hemorheological parameter is detected, from the first hemorheological parameter detected by the first sensor unit and a second hemorheological parameter and the arterial pressure detected by the second sensor unit.

Abstract: Provided is a video-based method and system for accurately estimating heart rate and facial blood volume distribution, and the method mainly comprises the following steps: firstly, carrying out face detection of video frame containing human face, and extracting face image sequence and face key position points sequence in time dimension; secondly, compressing these sequence of face image and face key position points to obtain the facial signals in time dimension; thirdly, estimating facial blood volume distribution by facial signals mentioned in third step; finally, estimating heart rate values by using model based on deep learning technology and the spectrum analysis method respectively, then fusing the estimation results by Kalman filter to promote the accuracy of heart rate estimation.

Abstract: A smart wearable device includes a display screen, a rear cover that engages with the display screen, a light generator, and a light receiver. The light generator and the light receiver are disposed in a mounting cavity formed after the display screen engages with the rear cover, the light generator is configured to emit light to an outer side of the rear cover, the light receiver is configured to receive light transmitted from the outer side of the rear cover, the light generator is disposed on a first control panel, the light receiver is disposed on a second control panel, and the light generator is disposed closer to the rear cover than the light receiver.

Abstract: A method for generating a transcranial magnetic stimulation (TMS) coil pose atlas based on electromagnetic simulating calculation includes: constructing coil array positions and orientations of a scalp in a standard Montreal Neurological Institute (MNI) space and matching the coil array positions and orientations of the scalp to a brain space of an individual to obtain coil array positions and orientations of the brain space of the individual; using a finite element calculation method to simulate the coil array positions of the brain space of the individual to obtain induced electric field distributions of brain tissue in different coil orientations; obtaining optimal regulation effects based on the induced electric field distributions of the brain tissue; and obtaining a coil position and orientation corresponding to each optimal regulation effect as an optimal coil pose of each divided brain area of the individual, and constructing a TMS coil pose atlas of the individual.

Abstract: Devices and methods are provided for non-invasive sensing of tissue fluid distribution in a patient. The device includes one or more magnets configured to provide a static magnetic field source; one or more RF transmitter coils connected to a pulse sequence generator which are configured to apply a varying magnetic field to tissues of the patient; one or more RF receiver coils configured to detect a magnetic field generated within tissues of the patient; and a signal acquisition and processor system configured to acquire signals from the RF receiver coils and perform an NMR measurement of a relaxation parameter of hydrogen nuclei within a muscle tissue site of the patient. A single-sided MR sensor device may include permanent magnets arranged in a unilateral linear Halbach array; and RF coils and a processor which are configured to produce a depth-resolved, diffusion-weighted, multicomponent T2 relaxometry measurements of intramuscular fluid shifts in a patient.

Abstract: A method for imaging a tissue region of a patient includes receiving a plurality of magnetic resonance (MR) signals of the tissue region, each MR signal being measured by a corresponding one of a plurality of coils, each coil having a different spatial sensitivity profile; and generating an image of the tissue region based on the plurality of MR signals and the spatial sensitivity profile of each coil, including applying one or more constraints to the image generation, wherein at least one of the constraints couples a first image value to one or more neighboring image values.

Abstract: Reference data relating to a portion of a patient anatomy during patient motion can be acquired from a magnetic resonance imaging system (MRI) to develop a patient motion library. During a time of interest, tracking data is acquired that can be related to the reference data. Partial volumetric data is acquired during the time of interest and at approximately the same time as the acquisition of the tracking data. A volumetric image of patient anatomy that represents a particular motion state can be constructed from the acquired partial volumetric data and acquired tracking data.

Abstract: Various arrangements for performing radar-based measurement of vital signs. Waveform data may be received then filtered of data indicative of static objects to obtain motion-indicative waveform data. The motion-indicative waveform data may be analyzed to determine one or more frequencies of movement present within the motion-indicative waveform data. A spectral analysis may be performed on the motion-indicative waveform data to determine a spectral-analysis state of a monitored region. The spectral-analysis state of the monitored region may be determined to match a predefined spectral-analysis state during which vital sign monitoring is permitted. One or more vital signs of a monitored user present within the monitored region may be determined and output based on analyzing the motion-indicative waveform data.

Abstract: A measuring device and a measuring method according to embodiments of the present disclosure can measure an index related to a heart with high accuracy. The present disclosure provides a measuring device configured to measure an index related to a heart of a living body. The measuring device includes: a transmitting unit and a receiving unit that can transmit microwaves at a plurality of different locations of the living body and measure the transmitted microwaves; a detecting unit that can acquire waveform parameters of the microwaves measured at the plurality of locations and compare the waveform parameters; and a detecting unit that can position the transmitting unit and the receiving unit that measure the microwave used to calculate the index among the microwaves measured at the plurality of locations based on a comparison result obtained by the detecting unit.

Abstract: An AC current of a particular frequency is setup in a body to be sensed, and amplitudes and phases of AC voltages at many electrodes attached to the body are detected simultaneously. Two modulating signals of the same frequency as the introduced AC current, one in phase with the AC input and one 90 degrees out of phase with it, are provided at all electrode measurement circuits. At the electrode measurement circuit, each of the modulating signals is mixed separately with the electrode signal using non-linear circuit components such as transistors or diodes. The output of this mixed signal is stored as a charge, in a capacitor or a semiconductor device (e.g. a CMOS transistor) that can store charge when in a certain state. Upon assertion of a readout signal, the charge is converted back into voltage and sent out on an analog voltage output line from which it is read using ADCs. The charge is reset upon the assertion of a reset signal.

Abstract: A spirometer comprises a housing defining a fluid flow pathway extending between a first end and a second end, a first opening along the pathway and a second opening longitudinally spaced along the pathway from the first opening. A flow chamber defining a fluid flow pathway is disposed within the housing between the first opening and the second opening, the flow chamber including an elongated resistive element along the central longitudinal axis of the flow chamber for defining a flow passage through the flow chamber between the resistive element and the inner surface of the flow chamber. The flow chamber conditions fluid flow for accurate sensing of the fluid flow over a range. A pressure sensor is disposed within the housing in fluid communication with the first opening and the second opening for sensing a pressure differential between the first opening and the second opening and producing an electric signal that corresponds with the rate of fluid flow through the housing.

Abstract: A respiration measurement device includes: a first body which has an air flow path formed therein to allow air generated by respiration of a user to be introduced and moved therethrough, a part of the air flowpath being opened to form an opening; a second body which includes a respiration. measurement unit for measuring the pressure of air moving through the air flow path, is detachably formed at the first body, and is installed to close the opening formed through the first body; and a mouthpiece which is detachably coupled to the inlet side of the air flow path.

Abstract: There is provided a kit of parts for an exhaled breath condensate collection device. The kit comprises a mouthpiece module comprising a breath passageway defined in the mouthpiece module providing fluid conduction from a mouthpiece breath inlet port for receiving exhaled breath to a mouthpiece breath outlet port in use. The kit further comprises a collection vessel for insertion into the device for cooling in use. The collection vessel defines a sealed and resealable chamber for collecting exhaled breath condensate in use. The collection vessel has a vessel breath inlet for admitting exhaled breath into the chamber. The kit of parts is configured such that the collection vessel is: insertable into the device into an sample collection configuration in which the vessel breath inlet is unsealed and in fluid communication with the mouthpiece breath outlet port of the mouthpiece module; and removable from the device in a sample containment configuration in which the collection vessel chamber is resealed.

Abstract: A system and method for monitoring a walking activity are disclosed, which have three major components: a pre-processing phase, a step detection phase, and a filtering and post-processing phase. In the preprocessing phase, recorded motion data is received, reoriented with respect to gravity, and low-pass filtered. Next, in the step detection phase, walking step candidates are detected from vertical acceleration peaks and valleys resulting from heel strikes. Finally, in the filtering and post-processing phase, false positive steps are filtered out using a composite of criteria, including time, similarity, and horizontal motion variation. The method 200 is advantageously able to detect most walking activities with accurate time boundaries, while maintaining very low false positive rate.

Abstract: A method for monitoring a recumbent patient to obtain information on a body position of the patient comprises the steps of emitting electromagnetic waves by a sender (11) arranged in a distance from the patient, receiving electromagnetic waves reflected by the patient by a receiver (12, 13, 14) arranged in a distance from the patient, determining a movement activity level from an amplitude and/or phase of the received electromagnetic waves, classifying the activity level into at least one high activity level class and into at least one low activity level class and analyzing the amplitude and/or phase of the received electromagnetic waves relating to an activity level classified in the at least one low activity level class to obtain the information on the body position of the patient.

Abstract: A system, device, and method to determine a dominant activity observed from body-worn sensors and accurately characterize the activity. Various embodiments may include using Periodicity Transform (PT) along with Partial Cycle Measurement (PCM) calculations to detect a dominant activity associated with a data interval from one or more data channels. For example, in a body-worn sensor (e.g., chest-worn, limb-worn, etc.), there may be contradictory signals that overlap in time, frequency, amplitudes, and/or the like, and this overlapping data may convey the specific dominant information in a mixed way. Various embodiments described herein seek to determine the dominant source of information from any channel by using fractional cycles and periodicity transforms.

Abstract: Provided is an information processing device including an acquisition unit configured to acquire motion information of a foot of a user measured by a motion measurement device provided on the foot and a feature amount extracting unit configured to extract a feature amount used for identifying the user from time series data of at least one walking cycle included in the motion information.

Abstract: The present patent of invention describes a high-resolution portable biometric reader for newborns that, according to the characteristics thereof, provides for the creation of a biometric reader for newborns (1) in a curved portable structure of electronic type and based on a frame and a comfortable handle enabling the operator to hold the reader in a single hand and arrange the capture surface area according to the newborn's position thus enabling the fingerprints of the newborn and those of the mother to be digitally captured using the frustrated total internal reflection technique with a prism as an optical system (4) having a resolution greater than 29 lp/mm (1450 ppi) over the entire capture area of more than 18×36 mm, so as to provide full optimization in the capturing procedures for fingerprint, palm-print and footprint imaging of newborn babies and the fingerprints of the respective mothers, i.e.

Abstract: Embodiments herein relate to ear-wearable device that can be used to detect conditions associated with the ears and related methods. In an embodiment, an ear-wearable device is included having a control circuit, a microphone, an electroacoustic transducer for generating sound in electrical communication with the control circuit, a motion sensor, and a power supply circuit, wherein the ear-wearable device is configured to provide auditory stimulation across a range of frequencies with the electroacoustic transducer, detect vibrations within or about the ear with the microphone, and identify a resonant vibrational frequency based on detected vibrations. Other embodiments are also included herein.

Abstract: An exemplary hearing evaluation system is configured to obtain a first auditory measurement dataset representative of one or more auditory measurements corresponding to a first ear of a user and that are acquired using a first auditory measurement test procedure having a first acoustic stimulus attribute set, obtain a second auditory measurement dataset representative of one or more auditory measurements corresponding to a second ear of the user and that are acquired using a second auditory measurement test procedure having a second acoustic stimulus attribute set different than the first acoustic stimulus attribute set, obtain a questionnaire response dataset representative of one or more responses to one or more question items associated with the user, and determine, based on the first auditory measurement dataset, the second auditory measurement dataset, and the questionnaire response dataset, a hearing profile of the user.

Abstract: The present invention relates to an optical sensing-type needle-type biosensor, and provides a needle-type biosensor comprising: a hollow microneedle comprising an internal channel connected to a tip end portion; a fluorescent sensor provided in the internal channel and producing fluorescence by binding to a specific target material; and a reader for detecting the fluorescence from the fluorescent sensor, wherein the internal channel comprises a region where the diameter of one end thereof connected to the tip end portion is increased.

Abstract: Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.

Abstract: The present invention provides an electrochemical biosensor comprising a carbon nanotube for measuring biosignals. The electrochemical biosensor for continuous glucose monitoring comprises an electrode to which a sensing film including an oxidoreductase, an electron transfer mediator, and a crosslinker is fixed, together with a carbon nanotube, wherein the oxidoreductase oxidizes a target substance and the electron thus generated in the oxidation process is transferred through the electron transfer mediator and the carbon nanotube, whereby the electrochemical biosensor can be used as a sensor having an excellent performance for continuous glucose monitoring.

Abstract: A sensing device includes a base, a probe structure and a transmitter structure. The base is provided with a first fastener part. The probe structure includes a second fastener part, a probe and a connection area. The transmitter structure includes a transmitter housing and a transmitter disposed inside the transmitter housing, the transmitter housing is provided with a connection hole, the shape of which matches the shape of the probe structure, and when the transmitter structure is mounted to the base, the probe structure is located in the connection hole, and the transmitter is electrically connected to the connection area to receive the signal generated by the probe.

Abstract: A system may include an implantable structure with a plurality of electrodes attached thereto, where the implantable structure is configured to be implanted proximate to a nerve that innervates and is proximate to an organ involved with glucose control. The system may further include a controller configured for use to control which of the plurality of electrodes are modulation electrodes and which of the plurality of electrodes are sense electrodes, a modulation energy generator configured to deliver modulation energy using one or more of the modulation electrodes, and a nerve traffic sensor configured to sense nerve traffic in the nerve using one or more of the sense electrodes. The controller may be configured to determine if the delivered modulation energy captures the nerves based on the sensed neural activity.