Abstract: Disclosed is a method of building a customized deep learning (DL) stack classifier to detect organization sensitive data in images, referred to as image-borne organization sensitive documents, and protecting against loss of the image-borne organization sensitive documents, including distributing a trained feature map extractor stack, with stored parameters, configured to allow the organization to extract from image-borne organization sensitive documents, feature maps that are used to generate updated DL stacks and to save non invertible feature maps derived from the images, and ground truth labels for the image. Also included is receiving organization-specific examples including the non-invertible feature maps extracted from the organization-sensitive documents and the ground truth labels and using the received organization-specific examples to update a customer-specific DL stack classifier. Further included is sending the customer-specific DL stack classifier to the organization.

Abstract: The present disclosure provides a bone conduction based sound generating lollipop, a processing method and a system thereto. The bone conduction based sound generating lollipop includes a housing, a trigger, a controller and a sound generating component. The sound generating component, the controller and the trigger are integrated in a packaging cavity formed by the housing, and a separate packaging of the sound generating component is eliminated. When a supporting component of the housing enters a human oral cavity, the trigger sends an opening instruction to the controller, the controller drives the sound generating component to vibrate, and then a vibration signal is transmitted to a human auditory system in a bone conduction manner after passing through the supporting component of the housing and an edible object attached to the supporting component, and passing through an oral tissue or teeth of the human body.

Abstract: Embodiments are directed to providing integrity-protected command buffer execution. An embodiment of an apparatus includes a computer-readable memory comprising one or more command buffers and a processing device communicatively coupled to the computer-readable memory to read, from a command buffer of the computer-readable memory, a first command received from a host device, the first command executable by one or more processing elements on the processing device, the first command comprising an instruction and associated parameter data, compute a first authentication tag using a cryptographic key associated with the host device, the instruction and at least a portion of the parameter data, and authenticate the first command by comparing the first authentication tag with a second authentication tag computed by the host device and associated with the command.

Abstract: Techniques are described, as implemented by computing devices, to control access to transactions through use of security deposits based on tokenized reputation scores. This is performed by leveraging a blockchain such that tokenized reputation scores are generated based on amounts of cryptographic reputation tokens associated with blockchain account addresses associated with service provider accounts. Access to transactional functionality is controlled for a service provider account by using an amount of cryptographic reputation tokens as a security deposit, where the security deposit is calculated based on a tokenized reputation score of the service provider account. Further, return of a security deposit is controlled for a service provider account based on a determination of a successful or unsuccessful completion of a transaction.

Abstract: A camera system may include one or more voice coil motor (VCM) actuators to implement focus, tilt and shift functions. The VCM actuators may include coils segmented into multiple coil segments having individually impedances lower than the impedance of the respective coil as a whole. The coil segments may be individually driven by respective currents at different points in time to interact with magnet(s) to produce motive forces along the same axis. Based on the winding configuration and driving mode of the coil segments, the motive forces may move a lens group relative to an image sensor in a direction substantially orthogonal to an image plane, tilt the lens group relative to the image sensor, or shift the image sensor relative to the lens group on the image plane.

Abstract: System configuration data characterizing a configuration of a fueling station system that includes a fueling station controller and an electronic fueling station component, each located at a fueling station, can be received. Component configuration data characterizing a configuration of the electronic fueling station component can be received. A query can be determined based on the received component configuration data and the received system configuration data. The query can be provided to a remote database, and the remote database can be configured to determine, based on the received query, operation data characterizing data required to operate the fueling station system. The operation data can be received from the remote database. The fueling station controller and the electronic fueling station component can be configured to operate based on the received operation data and the received system configuration data. Related apparatus, systems, methods, techniques, and articles are also described.

Abstract: The present invention provides novel and stable pharmaceutical compositions comprising bispecific single chain antibody constructs, cyclodextrins and a buffer.

Abstract: Examples described herein are generally directed to facilitating access to container state through multiple protocols. According to an example, a distributed state store is provided in which container state is accessible by multiple client containers via nodes of the distributed state store across which the container state is replicated. Responsive to receipt from a first client container of a storage request via a first application programming interface (API) method of the distributed state store that is associated with a first protocol, the container state is stored within the distributed state store. Responsive to receipt from a second client container of an access request via a second API method of the distributed state store that is associated with a second protocol, the container state is returned to the second client container via the second protocol.

Abstract: A method for communication with multiple connections is provided. The method can include sending a first message frame and a second message frame with a first connection and a second connection among the multiple connections, respectively, and resending the first message frame after a first waiting duration, in response to receiving a second feedback message frame related to the second message frame with the second connection and not receiving a first feedback message frame related to the first message frame with the first connection.

Abstract: A detection system and a portable detection device for detecting an object of interest in a lateral flow immunoassay strip. The lateral flow immunoassay strip has a detection carrier and a reporter, the detection carrier has a control zone and a test zone. The detection system has a laser light source, a scanning and spatial modulation module, a signal acquisition assembly, and a processing device. The laser light source provides a laser light. The scanning and spatial modulation module receives the laser light, and then provides a scanning and spatially modulating laser beam for irradiating a lateral flow immunoassay strip to generate a detecting signal. The signal acquisition assembly receives the detecting signal. The processing device electronic connects to the signal acquisition assembly and receives the detecting signal from the signal acquisition assembly.

Abstract: This disclosure relates generally to video coding and particularly to intra block copy (IBC) padding mode. One method is disclosed for performing an IBC padding. The method includes receiving a coded video bitstream; extracting, from the coded video bitstream, a first syntax element, the first syntax element indicating that an IBC padding is available for a current video block; extracting, from the coded video bitstream, a second syntax element, the second syntax element indicating that the current video block is predicted using the IBC padding; extracting, from the coded video bitstream, at least one syntax element; partitioning the current video block into at least two sub-partitions based on the at least one syntax element, wherein the at least two sub-partitions comprise a padding sub-partition and an IBC sub-partition; predicting the padding sub-partition based on a predefined padding rule; and predicting the IBC sub-partition based on a predefined IBC rule.

Abstract: The present disclosure provides systems and methods for calibrating for errors dependent upon spectral characteristics of tissue for a medical device by estimating a spectral characteristic of tissue providing error due to scattering or absorption of emitted light based upon operating the sensor in reflectance mode to generate a first SpO2 reading and estimating error due to spectral characteristics of skin therefrom, operating the sensor in transmissive mode to generate a second SpO2 reading, and applying a correction to a pulse oximetry transmissive mode measurement to correct for the error dependent upon the estimated spectral characteristic of tissue.

Abstract: A method of treating a subject suffering from Gaucher Disease is provided, the method including administering to the subject an effective amount of a composition including saposin C, dioleoylphosphatidylserine (SapC-DOPS), and acid ?-glucosidase (GCase). Also provided is a nanovesicle including saposin C, dioleoylphosphatidylserine, and acid ?-glucosidase and pharmaceutical compositions including the SapC-DOPS-GCase nanovesicles.

Abstract: A turning method for performing a turning on a workpiece in a machine tool includes: feeding a tool in a rotation axis direction and/or a radial direction of a workpiece while rotating the workpiece, the tool including an insert having a side cutting edge, the side cutting edge including a straight line portion; and feeding the tool in the rotation axis direction and the radial direction and in a predetermined inclined direction that is non-parallel to a final machining surface of the workpiece, so as to perform a turning such that a cutting edge angle as an angle formed by the straight line portion of the side cutting edge and the inclined direction becomes less than 90°.

Abstract: Disclosed in the present invention are a crystal form of a TrkA inhibitor and a preparation method therefor, and an application thereof in preparation of drugs for treating diseases associated with pain, cancer, inflammation, neurodegenerative diseases, and certain infectious diseases.

Abstract: An electronic device is provided. The electronic device includes a communication circuit, at least one processor, and a memory. The memory may store instructions which, when executed, cause the at least one processor to participate in a push-to-talk (PTT) session of an off-network mode, receive a media packet including media data from an external electronic device of the PTT session while possessing a floor of the PTT session, determine whether the floor of the PTT session is maintained, on the basis of at least one parameter included in the header of the media packet, and transmit, when the floor of the PTT session is not maintained, a message indicating release of the floor of the PTT session.

Abstract: Method of improving the efficiency of polyolefin production comprising: performing a reaction to yield (1) a product stream comprising a polyolefin, and (2) a purge stream, wherein the purge stream comprises unreacted monomers, inert impurities and saturated co-monomers; compressing the purge stream in a first stage compressor to create a first compressed stream; cooling the stream first compressed stream in a cooler to create a cooled stream; directing the cooled stream to a first drum, to create a waste liquid stream and a first drum stream; removing the waste liquid stream from the first drum; compressing the first drum stream in a second stage compressor to create a second compressed stream; condensing the second compressed stream to produce a condensed stream; processing the condensed stream in a second drum to produce a second drum gas stream and a second drum liquid stream; and, sending at least a portion of the second drum liquid stream to a polyolefin reactor.

Abstract: Embodiments of a device facilitate controlled positioning and manipulation of an individual's relative head, neck and jaw positions to facilitate stable airway management. In various embodiments, the device includes a base to which support arms are movably attached. A thrust arm is movably attached to each support arm and a jaw disc is attached to each thrust arm and adapted for rotation in accommodating various shapes and sizes of patient jaws.

Abstract: An information processing apparatus includes a detection result acquisition unit configured to acquire a detection result of a physical quantity that changes as a movable body moves while being in contact with a subject; an image data acquisition unit configured to acquire image data of the subject; and a display control unit configured to control a display to display likelihood information indicating a likelihood of abnormality of the subject and the image data in association with each other. The likelihood is determined based on the detection result.

Abstract: A receive end for wireless charging, a wireless charging method, and an electronic device are provided. The receive end is configured to charge a battery by using energy provided by a transmit end, and includes a receive coil, a matching circuit, a rectifier circuit, and a controller. An input terminal of the matching circuit is connected to the receive coil, and an output terminal of the matching circuit is connected to an input terminal of the rectifier circuit. The matching circuit is configured to: perform matching on the alternating current, and supply the alternating current to the input terminal of the rectifier circuit. The rectifier circuit includes a controllable switching transistor, and the rectifier circuit is configured to: rectify the input alternating current into a direct current under control of the controller, and supply the direct current to a charging control circuit.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: A soft tissue and bone repair system and corresponding method are provided which are particularly useful for labral repairs in the human shoulder. The system comprises at least two guide cannulae capable of being introduced into an anatomical structure of a human body at different entry points for repair of a tear in soft tissue. A pulling line can be passed within the anatomical structure between the guide cannulae. A guide device may be attached to the pulling line and inserted into one of the guide cannula. The guide device is capable of delivering a drilling device into the anatomical structure. The pulling line is capable of being pulled to move an end of the guide device from a one location to another within the anatomical structure to position the drilling device on a desired drilling path to access the tear in soft tissue.

Abstract: An occupant protection device is such that an airbag is housed in a housing region of a lap belt portion that can be disposed on a front side of a waist portion of an occupant seated in a seat. The airbag can receive and protect an upper body of the occupant using a rear face side occupant restraining face when inflation is completed. The airbag includes an exhaust port that can discharge an inflating gas and a regulating valve mechanism that restricts a discharge of the inflating gas from the exhaust port. The regulating valve mechanism permits a discharge of the inflating gas from the exhaust port when a protrusion upward of the airbag from the housing portion is restricted, and restricts a discharge of the inflating gas from the exhaust port when a protrusion upward of the airbag from the housing portion is not restricted.

Abstract: This application provides example communication methods, apparatuses, and systems. One example method includes receiving, by a user plane network element, characteristic information of a service data flow, where the characteristic information describes a characteristic of the service data flow. The user plane network element identifies a data packet group in the service data flow based on the characteristic information of the service data flow. The user plane network element sends the data packet group to an access network device.

Abstract: The invention is directed to biomarkers for predicting whether a patient will experience toxicity from radiation treatment or will have an increased risk of mortality, biochemical relapse, or distant failure despite undergoing radiation treatment.

Abstract: In some embodiments, a method includes receiving a target reproductive property associated with a managed livestock, and receiving an indication of health status of the managed livestock. The method further includes generating a set of input vectors based on the target reproductive property and the indication of health status. The method further includes providing the set of input vectors to a machine learning model trained to generate an output indicating a feed selection to be used to feed the managed livestock. The feed selection can be configured to, upon consumption, increase a likelihood of achieving the target reproductive property associated with the managed livestock. The method further includes administering a feed blend including the feed selection to the managed livestock.

Abstract: A shaped body including at least one section of a polyurethane foam. The shaped body includes a temperature-regulating device arranged in thermal contact with the at least one section of the polyurethane foam and a control device for the temperature-regulating device adapted to adjust the firmness of the at least one section of the polyurethane foam by alteration of temperature of the at least one section of the polyurethane foam this device being in “S” shape. The shaped body is used as a bed or mattress for promoting sleep in one application.

Abstract: A system and method of livestock management comprising a device disposed in a livestock animal. The device comprises a network interface, a housing defining a cavity, a weighted element, a power supply, a data processing unit, a temperature sensor and an accelerometer. The temperature sensor acquires temperature data of the livestock animal. The accelerometer acquires movement data of the livestock animal. The cavity includes a data processing system having at least one processor and memory. The data processing system is coupled with the power source and communicatively coupled with the temperature sensor and the accelerometer. The data processing system transmits, via the network interface, temperature data and movement data. The cavity includes an activation receiver to receive activation signal to activate the data processing system. A livestock management server receives and analyzes the data, along with any data from any additional data sources, and provides output to a user interface.

Abstract: A location information sharing control system enables detection of a location of an object person with precision while suppressing power consumption of a terminal carried by the object person, and enables a related person other than a specific manager to grasp the location of an object person. An object person terminal transmits identification information via short-range wireless communication. A detection terminal transmits the identification information transmitted from the object person terminal to the server. The server, on the basis of information transmitted from the detection terminal, specifies the location of the object person terminal, and manages the information on a location information sharing user who shares the information on the location of the object person terminal, and shares the information on the location of the object person terminal with the location information sharing user set to be able to share the information on the location of the object person terminal.

Abstract: The present disclosure relates to a memory structure and a forming method thereof. The present disclosure can improve the integration density of the memory structure. The memory structure includes: a plurality of vertical transistors, where the vertical transistors include silicon pillars; a plurality of the silicon pillars are arranged in m rows and n columns; the rows extend in a first direction and the columns extend in a second direction; m bit lines extending in the first direction and electrically connected to drains of all the vertical transistors in the same row, where the drains are located below the silicon pillars; and n word lines extending in the second direction, located in the middle of the silicon pillars, and serving as gates of all the vertical transistors in the same column, where the first direction and the second direction form a non-right angle.

Abstract: A single axis solar tracker includes two drive systems (motors) that both rotate a rotating shaft. The drive systems may be located about 16-25% from either longitudinal end of the rotating shaft.

Abstract: Embodiments of the present invention provide an energy management system and an energy management method, the system comprising: a reception unit for receiving energy price information from an energy supplier; an output unit for outputting predicted energy price information by inputting, into an artificial neural network (ANN), environment information including the energy price information; and a determination unit for determining the energy consumption action of each of a plurality of energy consumption devices at time (h) on the basis of determination information including the predicted energy price information, wherein the determination unit repetitively performs, until a set completion condition is satisfied, an update step of updating a Q value determined on the basis of an energy consumption state and an energy consumption action of each energy consumption device along time in order to determine the energy consumption action at time (h).

Abstract: The present disclosure raltes to an optical system, an image acquisition module and an electronic device. The optical system includes, successively in order from an object side to an image side: a first lens having a positive refractive power, an object side surface thereof being convex near an optical axis, an image side surface thereof being convex near the optical axis; a second lens having a negative refractive power, an object side surface thereof being convex near the optical axis, an image side surface thereof being concave near the optical axis; a third lens having a negative refractive power, an image side surface thereof being convex near the optical axis; a fourth lens having a positive refractive power; a fifth lens having a negative refractive power. The optical system satisfies the following condition: 11 mm?f/tan(HFOV)?12.5 mm.

Abstract: A medical system is provided with: a medical device that is inserted inside a living body; a distal end electrode that is disposed at a distal end of the medical device, and passes a high frequency to the living body from inside the living body; a magnetic sensor that is disposed outside the living body, and detects a magnetic field generated by the high frequency that has been passed from the distal end electrode to the living body; and an image generation portion that generates an internal image of the living body using magnetic field information output from the magnetic sensor.

Abstract: A disclosed system for transport asset monitoring, for example monitoring truck trailer unloading progress at large retail locations, includes an artificial intelligence (AI) solution for managing operations at a facility. The AI solution analyzes current load percentage and other data to predict availability for moving the transport asset and ability to accept a new incoming transport asset. Predictions of availability can reduce response times, resulting in higher utilization rates for assets, thereby improving efficiency. An exemplary system includes a sensor configured to sense operation progress parameter data for a transport asset; and logic to receive the operation progress parameter data from the sensor; determine, using the AI solution and based at least on the operation progress parameter data, a predicted milestone parameter; and report the predicted milestone parameter to a remote node.

Abstract: The present disclosure discloses a method and an apparatus for generating a vector representation of a knowledge graph, and relates to a field of a field of artificial intelligence technologies. The detailed implementing solution is: obtaining a knowledge graph, the knowledge graph including a plurality of entity nodes; obtaining a context type and context data corresponding to the knowledge graph; and generating vector representations corresponding to the plurality of entity nodes by a context model based on the context data and the context type.

Abstract: A vortex ring generation device is configured to release an airflow in a form of a vortex ring from a release port. The vortex ring generation device includes a plurality of gas chamber units, an actuator, and a communication path. Each gas chamber unit has an air chamber that communicates with the release port. Each gas chamber units includes a fixing member forming the air chamber, and a movable member moving to push air out of the air chamber. The movable members of all of the gas chamber units are coupled together to form one movable body. The actuator is connected to an end portion of the movable body and is configured to drive the movable body. The communication path allows the air chambers of the plurality of gas chamber units to communicate with each other.

Abstract: A deployment of sensors transmit radio frequency (RF) signals into an area of interest. The radar maps are generated from the reflected signals, including a static radar map and a dynamic radar map. Multipath and radar sidelobes are removed from the radar maps using a neural network to produce a density map. The neural network can be trained in two phases: a training phase that uses training data from a training site and a transfer learning phase that uses training data from the area of interest.

Abstract: A device may receive technician data identifying home geographical locations of technicians and base station data identifying geographical locations of base stations, and may calculate travel distances and travel times between each of the technicians and each of the base stations based on the technician data, the base station data, and map data. The device may calculate technician distances between the technicians based on the technician data, and may determine the base stations to assign to each of the technicians, to generate groups of assigned base stations, based on a least cost model. The device may determine technician clusters based on processing the groups of assigned base stations with a clustering model, and may generate optimized technician assignments and modified groups of assigned base stations based on utilizing a balancing model. The device may perform one or more actions based on the modified groups of assigned base stations.

Abstract: A hydraulic steering arrangement (1) including a supply port (2), a return port (4), a working port arrangement having two working ports (5, 6), a main flow path (7) between the supply port (2) and one of the working ports (5) and a return flow path (8) between the other working port (6) and the return port (4), wherein the main flow path (7) includes a main orifice (A1), a flow meter (9), a first flow meter orifice (A2) upstream the flow meter (9), a second flow meter orifice (A3) downstream the flow meter (9), and a first working port orifice (A4), the return flow path (8) includes a second working port orifice (A5), a load sensing point (17) is arranged between the main orifice (A1) and the first flow meter orifice (A2), a drain orifice (Ad) is arranged between the load sensing point (17) and the return port (4), and a priority valve arrangement (10) is arranged between the supply port (2) and the main orifice (A1). Such a steering arrangement should enable a high steering speed without loss of comfort.

Abstract: A device for receiving signals via an electrically driveable or adjustable furniture element includes a receiving device for receiving at least one wirelessly transmitted signal, and the at least one wirelessly transmitted signal that has been received by the receiving device can be transmitted on to a furniture element. The receiving device is designed such that the at least one wirelessly transmitted signal can be received and processed via a first transmission protocol and a second transmission protocol, wherein the first transmission protocol is different from the second transmission protocol.

Abstract: A method performed by a user equipment (UE) for multiple transmission and reception points (multi-TRP) based physical uplink shared channel (PUSCH) transmission is provided. The method includes receiving, from a base station (BS), a Radio Resource Control (RRC) parameter that enables the UE to derive a default uplink (UL) spatial filter for PUSCH transmission; receiving, from the BS, a downlink control indication (DCI) format 0_0 that schedules the PUSCH transmission on a serving cell; determining one or two default UL spatial filters for the PUSCH transmission; and applying the one or two default UL spatial filters to perform the PUSCH transmission.

Abstract: Embodiments are disclosed for a system. The system includes a semiconductor structure. The semiconductor structure includes a dielectric liner that wraps around a top and one side of a substrate island. The dielectric liner separates a substrate from a gate stack. Further, the system includes an access trench in physical contact with the dielectric liner.

Abstract: A cache system, having cache sets, a connection to a line identifying an execution type, a connection to a line identifying a status of speculative execution, and a logic circuit that can: allocate a first subset of cache sets when the execution type is a first type indicating non-speculative execution, allocate a second subset when the execution type changes from the first type to a second type indicating speculative execution, and reserve a cache set when the execution type is the second type. When the execution type changes from the second to the first type and the status of speculative execution indicates that a result of speculative execution is to be accepted, the logic circuit can reconfigure the second subset when the execution type is the first type; and allocate the at least one cache set when the execution type changes from the first to the second type.

Abstract: A consumer product having a detergent product and a container, particularly containers that include corrugated fiberboard, where the container includes a box and a lid having a top panel and flanks, the flanks having at least a first flank that has a first major flap, the first major flap having a first flank corrugated fiberboard layer. Methods of manufacturing and using such products and containers.

Abstract: In general, embodiments of the present invention provide for ranking data objects using machine learning and scoring to configure a graphical interface. In this regard, a machine learning model is applied to data object attributes to generate data object relevance scores for the candidate data objects. Additionally, a respective personalization score for the candidate data objects is generated based at least in part on a compounded ratio and a geometric mean of the compounded ratio. The data object relevance scores for the candidate data objects are modified based at least in part on the respective personalization score for the candidate data objects to generate modified object relevance scores for the candidate data objects. The candidate data objects are then ranked based at least in part on the modified object relevance scores to generate a ranked data object set and to facilitate configuration of a graphical interface.

Abstract: An electronic apparatus and a controlling method thereof are provided. The electronic apparatus includes a display, a memory configured to store at least one instruction, and a processor configured to control the electronic apparatus by executing at least one instruction stored in the memory, and the processor is configured to receive a user input for entering a first mode, perform a search based on a search word corresponding to a user history in a first application related to the first mode in response to the user input, and display a first image provided by the first application on a first area of the display based on a result of the search, and control the display to display a second image obtained through a camera connected to the electronic apparatus on a second area of the display.

Abstract: Static/Fixed-time meeting notifications may not be adequate and are not useful if the user is not online when the static/fixed-time reminder is sent. Systems, methods, and software to provide intelligent reminders. In one embodiment, presence data associated with a user is collected and stored. A calendar of the user is accessed to determine if any meetings have a start time occurring within a predetermined timeframe, wherein the predetermined timeframe is determined based on the presence data associated with the user. For each identified meeting that occurs within the predetermined time frame, determining a notification time based on the presence data associated with the user and presenting a notification at the determined notification time.

Abstract: A fresh-keeping device for a refrigerator, and a refrigerator. The fresh-keeping device includes a fresh-keeping box body having a lower frame and an upper frame, the lower frame being provided with an accommodating space as well as an opening and a gas inlet communicated with the accommodating space, the upper frame being provided with a refrigerating air channel, and the refrigerating air channel being used for refrigerating the accommodating space; a drawer is configured to enter from the opening and accommodated in the accommodating space to fit the fresh-keeping box body to form the sealed accommodating space; and a nitrogen generating means connected to the side of the fresh-keeping box body on which the gas inlet is formed and is configured to charge generated nitrogen into the accommodating space from the gas inlet.

Abstract: Treatment of CHD1L-driven cancers, including TCF transcription-driven cancers and EMT-driven cancers using CHD1L inhibitors. Small molecule inhibitors of CHDL1 which inhibit CHD1L ATPase and inhibit CHD1L-dependent TCF-transcription have been identified. CHD1L inhibitors prevent the TCF-complex from binding to Wnt response elements and promoter sites. More specifically, CHD1L inhibitors induce the reversion of EMT. CHD1L inhibitors are useful in the treatment of various cancers and particularly CRC and m-CRC. The CHD1L-driven cancer is among others, CRC, breast cancer, glioma, liver cancer, lung cancer or gastrointestinal (GI) cancers. CHD1L inhibitors of formulas I and XX and salts thereof as defined herein are provided as well as pharmaceutical compositions containing CHD1L inhibitors. Synergistic combinations of CHD1L inhibitors with other antineoplastic agents are also described.