Abstract: A novel peptide analog of acylated oxyntomodulin and its uses are disclosed. A pharmaceutical composition containing the novel peptide analog is useful and effective for preventing and treating obesity or overweightness, or diabetes accompanied by obesity and overweightness. The peptide analog and a composition containing the peptide analog are superior to those of wild-type oxyntomodulin in dual agonism on GLP-1 and glucagon receptors and longer in vivo half-life. A pharmaceutical composition containing the peptide analog is effective in the treatment of metabolic diseases such as obesity and diabetes mellitus.

Abstract: Provided herein are GLP1-GDF15 fusion proteins comprising a GLP1 or GLP1 variant peptide, a first linker peptide, a serum albumin protein, a second linker peptide, and a GDF15 protein.

Abstract: The present invention provides Claudin-18.2-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T cell epitopes which are useful for immunotherapy.

Abstract: The instant invention provides binding proteins (“CD38-binding proteins”) which each comprise (1) a CD38-binding region for cell-targeting and (2) a Shiga toxin A Subunit effector polypeptide (“Shiga toxin effector polypeptide”). The Shiga toxin effector polypeptide components of the CD38-binding proteins may comprise a combination of mutations relative to a wild-type Shiga toxin sequence providing (1) de-immunization and/or (2) a reduction in protease sensitivity; wherein each Shiga toxin effector polypeptide retains one or more Shiga toxin function, such as, e.g., stimulating cellular internalization, directing intracellular routing, catalytic activity, and/or potent cytotoxicity. The CD38-binding proteins may have one or multiple uses, e.g., the selective killing of a specific CD38-expressing cell-type; and more generally, for the diagnosis and treatment of cancers and disorders involving CD38-expressing cells, e.g., in CD38-positive hematopoietic cancers such as multiple myeloma.

Abstract: The present disclosure relates to a scFv amino acid sequence capable of recognizing CD19 antigen and a nucleotide sequence encoding the same, and also relates to a chimeric antigen receptor, a nucleic acid encoding the same and a cell expressing the same, and their uses in the manufacture of a medicament for treating tumors. The chimeric antigen receptor of the present disclosure comprises at least one extracellular domain, an optional transmembrane domain and at least one intracellular costimulatory signaling domain, wherein the extracellular domain comprises a CD19 antigen-recognizing and binding domain. The chimeric antigen receptor of the present disclosure has been humanized, resulting in a longer survival period in vivo, and a corresponding extended complete remission period in patients.

Abstract: This disclosure relates to antibodies and antigen binding fragments that specifically bind Ebola virus particles. In certain embodiments, the antibodies and fragments are capable of treating or preventing an Ebola viral infection. In certain embodiments, the antibodies and antigen binding fragments are also contemplated for diagnostic methods and compositions related thereto.

Abstract: The present invention relates to a medicine for treating disorders of glucose and/or lipid metabolism. This invention demonstrates a new therapeutic target for treatment of glucose and/or lipid metabolic disorders. The invention further provides a method of treating glucose and/or lipid metabolic disorders, administering to a subject comprising a Nogo-B inhibitor, thereby treating the glucose and/or lipid metabolic disorders.

Abstract: The present invention relates to methods for preventing or treating head and neck squamous cell cancer and bladder cancer using an immunotoxin comprising (a) a ligand that binds to a protein on the cancer cell attached to; (b) a toxin that is cytotoxic to the cancer cell. In a specific embodiment, the invention is directed to the prevention or treatment of head and neck squamous cell cancer or bladder cancer using Vb4-845, which is a recombinant immunotoxin comprising a humanized, MOC31-derived, single-chain antibody fragment that is fused to a truncated form of Pseudomonas exotoxin A. Also encompassed by the invention are combination therapy methods, including the use of reduced dosages of chemotherapeutic agents, for the prevention or treatment of cancer. Also encompassed by the invention are formulations and methods for direct administration of the recombinant immunotoxin to the carcinoma, for the prevention or treatment of cancer.

Abstract: The present invention relates to methods for preventing or treating head and neck spuamous cell cancer and bladder cancer using an immunotoxin comprising (a) a ligand that binds to a protein on the cancer cell attached to; (b) a toxin that is cytotoxic to the cancer cell. In a specific embodiment, the invention is directed to the prevention or treatment of head and neck squamous cell cancer or bladder cancer using Vb4-845, which is a recombinant immunotoxin comprising a humanized, MOC31-derived, single-chain antibody fragment that is fused to a truncated form of Pseudomonas exotoxin A. Also encompassed by the invention are combination therapy methods, including the use of reduced dosages of chemotherapeutic agents, for the prevention or treatment of cancer. Also encompassed by the invention are formulations and methods for direct administration of the recombinant immunotoxin to the carcinoma, for the prevention or treatment of cancer.

Abstract: Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-1. Also provided are methods of making and using these constructs.

Abstract: The present invention relates to antagonists, particularly antibodies and antigen binding fragments thereof, that bind to the protein galectin-10, particularly human galectin-10. The galectin-10 antagonists disrupt the crystallization of galectin-10 and are therefore useful in methods of preventing and treating diseases and conditions wherein the pathology is linked to the formation/presence of Charcot-Leyden crystals (CLCs).

Abstract: The present invention relates to combination therapies with anti-CD38 antibodies.

Abstract: The present invention provides new modified anti-SIRPa antibodies linked to an immunotherapeutic agent which are bifunctional and able to specifically enhance the immune response and uses thereof.

Abstract: Provided by the invention is an antibody or an antigen-binding fragment thereof, which binds to a CD38 protein at a KD value below 1×10-9M. The antibody or an antigen-binding fragment thereof has strong specific recognition and binding capabilities for CD38 protein, and may kill CD38+ cells by means of antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and/or apoptosis. Further provided by the present invention is an application of the antibody or antigen-binding fragment thereof in preventing and treating tumors.

Abstract: The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.

Abstract: The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer, each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

Abstract: An object of the present invention is to provide an efficient method for producing cellulose nanofibers, without N-oxyl compounds such as TEMPO remaining in the cellulose nanofibers. Provided is a method for producing cellulose nanofibers, the method including: oxidizing a cellulose raw material with hypochlorous acid, or a salt thereof, having an available chlorine concentration of from 14% by mass to 43% by mass, to produce an oxidized cellulose; and fibrillating the oxidized cellulose into nanofibers.

Abstract: This invention relates to novel hydrogenation catalyst compositions obtainable from reacting metal-based complex hydrogenation catalysts with specific co-catalysts and to a process for selectively hydrogenating nitrile rubbers in the presence of such novel hydrogenation catalyst compositions.

Abstract: A depolymerizer is formed by grafting thiol groups on parts of the double bonds of a polymer of linear conjugated diene monomer. The linear conjugated diene monomer can be 1,3-butadiene, isoprene, 1,3-pentadiene, 2,3-dimethyl-1,3-butadiene, 2-methyl-1,3-pentadiene, 2,3-dimethyl-1,3-pentadiene, 2-phenyl-1,3-butadiene, or 4,5-diethyl-1,3-octadiene. The depolymerizer has a weight average molecular weight of 1000 to 400000.

Abstract: Provided are an apparatus and a method for manufacturing high-pressure method low-density polyethylene, the apparatus and the method having excellent characteristics that the amount of smoke generated during processing of a polyethylene to be obtained is small, and the number of fish eyes contained in a film formed from the polyethylene is small. An apparatus for manufacturing high pressure method polyethylene includes: an ethylene supply line that is a line branched from a high pressure recycle ethylene line and connected to a recycle ethylene holding drum for decompressing high pressure recycle ethylene from the high pressure recycle ethylene line and supplying the decompressed recycle ethylene to the recycle ethylene holding drum; and the recycle ethylene holding drum that is a drum for holding the decompressed recycle ethylene through the ethylene supply line.

Abstract: The present disclosure provides base stocks and or diesel fuel, and processes for producing such base stocks and or diesel fuel by polymerizing alpha-olefins and internal olefins. The present disclosure further provides polyolefin products useful as base stocks and or diesel fuel. In at least one embodiment, a process includes: i) introducing, neat or in the presence of a solvent, a feed comprising a branched C5-C30 internal olefin, with a catalyst compound comprising a group 8, 9, 10, or 11 transition metal and at least one heteroatom and ii) obtaining a C6-C100 polyolefin product having one olefin, a methylene content of from about 1 wt % to about 98 wt %, and or a methyl content of from about 1 wt % to about 75 wt %. The feed may further include a linear C4-C30 internal olefin, a C2-C30 alpha-olefin, or a mixture thereof.

Abstract: A method for preparing a modified conjugated diene-based polymer is provided. The method is characterized in adding a polyoxyethylene phosphate ester-based compound having a specific structure together with sulfur chloride modifier during modification, by which modification reproducibility may be markedly improved, stable process may be performed, the changing degree of the physical properties, specifically a Mooney viscosity increasing ratio and the degree of branching of a modified conjugated diene-based polymer according to modification conditions may be anticipated, and the changing degree of a Mooney viscosity increasing ratio and the degree of branching may be easily controlled by controlling modification conditions.

Abstract: The present invention provides a resin composition for a model material, for obtaining an optically shaped article that has flexibility and does not crack even when it is bent, and a method for manufacturing optically shaped articles that are shaped using the resin composition for a model material. The present invention relates to a resin composition for a model material, comprising, based on 100 parts by weight of a whole resin composition, 20 to 90 parts by weight of a (meth)acrylate monomer represented by the following formula (1) and/or a (meth)acrylate monomer represented by the following formula (2) as a monofunctional monomer (A), and 5 parts by weight or more of a polyfunctional oligomer as an oligomer (B), and further comprises no or 15 parts by weight or less, based on 100 parts by weight of the whole resin composition, of polyfunctional monomer (C), wherein R1, R2 and R3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 3 carbon atoms.

Abstract: A resin composition useful for additive manufacturing is provided, which resin composition may exhibit improved shelf life through inhibition of crystallization. Such resin composition may include a crystallization inhibitor as taught herein, and/or a prepolymer produced by reaction of an isocyanate with multiple isomers and comprising a lower percentage of the structurally symmetric isomer. Methods of forming a three-dimensional object using such resin composition are also provided.

Abstract: Foamable waterborne dispersions which form stable flexible foams under ambient cure conditions are disclosed, said foamable waterborne dispersions comprising: a polyurethane polymer formed from one or more aliphatic or cycloaliphatic polyisocyanate and at least two different polymeric polyol components selected from polyether polyol, polyester polyol, and polycarbonate polyol; wherein the ambient cure conditions include a temperature of from 4° C. to 32° C., and a humidity of 0% relative humidity to 90% relative humidity. Also disclosed are the flexible foams produced from the foamable waterborne dispersions, as well as methods of providing a space filling layer or space filling volume adjacent to or on a surface, said methods comprising applying to said surface a foamed sample of the foamable waterborne dispersions, and allowing the foamed sample of foamable waterborne dispersion to dry under ambient conditions to yield a stable flexible foam.

Abstract: The presently claimed invention relates to a composition comprising polyurethane polymer and diluents, which is used as an additive in coating formulations, in particular water-borne paint and coating formulations, for reducing the effect of the viscosity loss caused by the addition of colorants/pigment pastes thereby improving the viscosity stability in tinted coating formulations as well as the method for preparing the composition.

Abstract: The disclosed technology provides improved thermoset vitrimers. It has been discovered that by incorporating adaptable dynamic groups along the polymer backbone, along with permanent, non-dynamic crosslinking points, an improved thermoset vitrimer is generated. In some variations, a thermoset vitrimer comprises: a linear polymer backbone containing associative dynamic covalently bonded species; a crosslinked network containing non-dynamic branch points; and non-dynamic species between non-dynamic branch points and terminal ends of the linear polymer backbone.

Abstract: The present invention relates to a polar functional group-partially introduced polymer, a preparation method therefor, and an organic electronic element adopting the same. The organic electronic element of the present invention has excellent photoelectric conversion efficiency and stability and is very advantageous in commercialization, by adopting the polar functional group-partially introduced polymer of the present invention.

Abstract: The present application relates to a dispersing resin, a universal color paste used for impregnating coating, and a preparation method therefor. The dispersing resin is prepared from a raw material including: diol, polyol, aromatic dicarboxylic acid, anhydride, maleic anhydride, polymerization inhibitor, reactive diluent, and azeotropic solvent.

Abstract: The present invention relates to a polyester resin. The polyester resin contains a particular content of diol moieties, derived from isosorbide and diethylene glycol, and thus can provide a resin molded product exhibiting high transparency in spite of a large wall thickness thereof.

Abstract: Aspects of the present disclosure relate to Schiff base oligomers and uses thereof. In at least one aspect, an oligomer is represented by Formula (I) wherein each instance of R4, R5, R6, R7, R8, R10, R11, R12, R13, and R14 is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxyl, aryloxyl, ether, and heterocyclyl. Each instance of R9 of Formula (I) is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, and ether. Each instance of R28 and R29 of Formula (I) is independently selected from the group consisting of hydrogen, alkyl, and aryl. Each instance of R33 of Formula (I) is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, and a bond. Each instance of R41 of Formula (I) is independently —NH— or a bond and each instance of R40 is independently —NH— or —NH—NH—.

Abstract: The present invention provides a barrier material formation composition comprising a silane oligomer, at least a part of the silane oligomer being modified with a metal alkoxide.

Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.

Abstract: This invention relates to a polymeric pipe, and more particularly a polymeric pipe where the pipe comprises a cross-linked polyolefin formed from extruded polyolefin comprising a bismaleimido crosslinker. This invention relates to the manufacturing of plastic pipes and tubing of polyolefinic polymers such as polyethylene, with crosslinking by a bismaleimido crosslinker, to produce crosslinked polyethylene (PEX) pipes and tubing.

Abstract: The polymer film according to an embodiment comprises at least one polymer resin selected from the group consisting of a polyamide-based resin, a polyimide-based resin, and a polyamide-imide-based resin, and has a haze of 0.6% or less and an in-plane retardation within a specific range for each wavelength band in the visible light region. The polymer film, which has an in-plane retardation within a specific range for each wavelength band in the visible light region, is excellent in transparency and optical properties, and it can remarkably reduce the rainbow phenomenon and improve the reflection appearance.

Abstract: The present invention is suitable for optical applications with excellent transparency through a haze value of 1.5% or lower and particles that are hardly visible to the naked eye, by producing a film using particles having little difference in refractive index in polyethylene terephthalate (PET), which is a commonly-used polyester film, and can provide a highly transparent optical film capable of improving a winding property by forming surface roughness of 4 nm or higher.

Abstract: A method for surface treatment of a silicone rubber includes: providing the silicone rubber bearing a polar group on a surface of the silicone rubber, and applying a multifunctional compound to the surface of the silicone rubber bearing the polar group to allow the multifunctional compound to react with the polar group to form a coating.

Abstract: Modified plastic surfaces with perfluoropolymers are provided, whereby plastic surfaces that are intended for use under tribological conditions have substantially improved assembly properties and/or sliding friction properties and exhibit a very low degree of wear. Accordingly, modified plastic surfaces with perfluoropolymers are provided in which modified perfluoropolymer (micro)powders are present at the surface of plastics that comprise olefinically unsaturated double bonds at least at the surface such that the modified perfluoropolymer (micro)powders are chemically covalently bonded via a radical coupling of the olefinically unsaturated double bonds with perfluoropolymer (peroxy) radicals of the modified perfluoropolymer (micro)powders after a reactive conversion under mechanical stress at room temperature.

Abstract: A polyurethane foam is disclosed having unique load bearing characteristics rendering it suitable for a variety of applications. The foam exhibits high surface-softness and smoothness properties, making it well-suited for use in articles such as pillows and mattress toppers. However, upon continued application of pressure, the resilience of the foam increases sharply, translating into a remarkable support characteristics that make the foam suitable for use in the seat portions of chairs and sofas, as well as in the base portion of mattresses. The foams therefore address the limitations of conventional, high-resilience and visco-elastic polyurethane foams. A process of making the foam and its use in various articles is also disclosed.

Abstract: To provide a method for producing a porous film in which even when minute fine particles are used, fine particles can be satisfactorily dispersed, a method for producing a composition for producing a porous film, and a porous film that can be produced by the method for producing a porous film. When a porous film is formed using a varnish including at least one resin component selected from the group consisting of polyamide acid, polyimide, a polyamide-imide precursor, polyamide-imide and polyethersulfone, and fine particles, varnish is produced by dispersing the fine particles by using a pressure device that pressurizes slurry including the fine particles and a dispersing device provided with a flow path whose cross-sectional area is 1960 ?m2 or more and 785000 ?m2 or less, and allowing the slurry pressurized to 50 MPa or more to pass through the flow path.

Abstract: A device (e.g., an article of athletic gear) comprising a post-molded expandable component, which is a part of the device that is configured to be expanded or has been expanded after being molded. This may allow the post-molded expandable component to have enhanced characteristics (e.g., be more shock-absorbent, lighter, etc.), to be cost-effectively manufactured (e.g., by using less material and/or making it in various sizes), and/or to be customized for a user (e.g., by custom-fitting it to the user).

Abstract: A process for fabricating a thermochromic film is disclosed which includes the steps of dispersing a predetermined amount of vanadium dioxide (VO2) nanoparticles in a predetermined amount of poly(methyl methacrylate) (PMMA), stirring a mixture thereof for a first predetermined amount of time, generating cross-links to molecule chains of the PMMA in the mixture, and blade coating a predetermined thickness of the cross-linked mixture on a substrate to form the thermochromic film.

Abstract: The present invention provides a stabilising composition, comprising: a) a first phenolic antioxidant comprising one or more phenolic compounds having the structure of formula (I): ?wherein R1 is a linear or branched alkyl group having from 12 to 20 carbon atoms; and b) one or more second phenolic antioxidants independently selected from: ?a mono-hydroxybenzene having lower steric hindrance than the first phenolic antioxidant; ?a di-hydroxybenzene; and/or ?a tri-hydroxybenzene.

Abstract: A method of testing the composition or quality of water includes dissolving about two parts by weight of a 2-hydroxybenzyl alcohol and about one part by weight of a sodium nitroprusside in about seventy-five parts by weight of a polyethylene glycol; adding the sodium nitroprusside solution to a water sample to catalyze an indophenol monochloramine reaction; and detecting the concentration of monochloramine in the water sample. The polyethylene glycol may be a polyethylene glycol 300, a PEG-400 or a PEG-1000. The method may also be accomplished with a solution made by dissolving a 2-hydroxybenzyl alcohol and a sodium nitroprusside in a mixture of propane-1,2-diol and water.

Abstract: A composition of matter having oxygen scavenging properties comprises a blend of a base polymer, a butadiene polymer, and titanium dioxide in an amount sufficient to catalyze reaction of oxygen with the butadiene polymer. In further aspects, methods for making the compositions herein and packaging film structures comprising the compositions herein, and packaging articles formed of the same, are also provided.

Abstract: An object of the present invention is to provide a propylene polymer composition capable of forming a heat seal layer that can be heat-sealed at a relatively low temperature and suppressing blocking in a film including the heat seal layer. A propylene polymer composition contains the following propylene polymer (1) and the following propylene-?-olefin copolymer (2), in which a content of the propylene polymer (1) is 2% by mass to 25% by mass with respect to 100% by mass of a total content of the propylene polymer (1) and the propylene-?-olefin copolymer (2), and the propylene polymer composition satisfies the following requirement (3): Propylene polymer (1): a polymer containing 94% by mass or more of a monomer unit derived from propylene. Propylene-?-olefin copolymer (2): a copolymer containing 60% by mass or more and less than 94% by mass of a monomer unit derived from propylene and more than 6% by mass and 40% by mass or less of a monomer unit derived from an ?-olefin having 4 to 12 carbon atoms.

Abstract: A thermoplastic elastomer composition for overmolding a predominantly polyamide substrate, a method for the preparation of an overmolded article, and an overmolded article having a layer of thermoplastic elastomer is provided. The thermoplastic elastomer composition comprises a thermoplastic vulcanizate, an olefinic block copolymer, and a maleated functionalized polyolefin copolymer. The method for the preparation of the overmolded article comprises heating the thermoplastic elastomer composition followed by applying the heated composition to at least a portion of the predominantly polyamide substrate.

Abstract: A resin composition includes 100 parts by weight of a maleimide resin; 20 parts by weight to 60 parts by weight of a benzoxazine resin; 5 parts by weight to 40 parts by weight of an epoxy resin; 120 parts by weight to 240 parts by weight of silica including spherical silica having a sediment volume of less than or equal to 0.4 mL/g and a particle size distribution D50 of less than or equal to 1.0 ?m; and 0.5 part by weight to 1.6 parts by weight of an imidazole compound having a long-chain alkyl group, wherein the imidazole compound having a long-chain alkyl group includes octylimidazole, undecylimidazole, heptadecylimidazole or a combination thereof.

Abstract: A polyester resin composition contains a polyester resin A containing 50 to 100 mass % of a polybutylene terephthalate resin and 0 to 50 mass % of a polyethylene terephthalate resin. The polyester resin composition further contains a predetermined amount of a metal organic acid salt B, which is either or both of an alkali metal organic acid salt and an alkaline earth metal organic acid salt; a predetermined amount of a styrenic resin C; and a predetermined amount of an inorganic filler D. The amount of linear oligomers of polybutylene terephthalate or the amount of the linear oligomers of polybutylene terephthalate and linear oligomers of polyethylene terephthalate is less than or equal to 1000 mg/kg. Inorganic filler D has an average particle size of 0.05 to 3 ?m.

Abstract: The present invention relates to a sinter powder (SP) comprising at least one semicrystalline terephthalate polyester (A), at least one amorphous terephthalate polyester (B) and at least one phosphinic salt (C). The present invention further relates to a method of producing a shaped body by sintering the sinter powder (SP) or by an FFF (fused filament fabrication) method, to a shaped body obtainable by the method of the invention, and to the use of a phosphinic salt in a sinter powder (SP) for broadening the sintering window (WSP) of the sinter powder (SP).