Patents Issued in August 1, 2023
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Patent number: 11713446Abstract: The present invention provides improved and/or shortened processes and methods for reprogramming TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy. Such reprogrammed TILs find use in therapeutic treatment regimens.Type: GrantFiled: May 4, 2022Date of Patent: August 1, 2023Assignee: IOVANCE BIOTHERAPEUTICS, INC.Inventors: Cecile Chartier-Courtaud, Krit Ritthipichai
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Patent number: 11713447Abstract: The invention is directed to production of megakaryocyte (MK) compositions and their the treatment of thrombocytopenia in a subject in need thereof.Type: GrantFiled: August 4, 2017Date of Patent: August 1, 2023Assignee: Icahn School of Medicine at Mount SinaiInventors: Camelia Iancu-Rubin, Ronald Hoffman
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Patent number: 11713448Abstract: Methods for producing hepatocytes from pluripotent human stem cells are disclosed herein. The stem cells are plated on a cell culture substrate comprising two laminins. The stem cells are then exposed to different cell culture mediums to induce differentiation. The resulting hepatocytes have higher metabolic capacity compared to hepatocytes cultured on different substrates.Type: GrantFiled: June 16, 2020Date of Patent: August 1, 2023Assignee: BIOLAMINA ABInventors: Louise Kristina Hagbard, Carl Gunnar Jesper Ericsson, Katherine Rachel Cameron, David Colin Hay, Stuart John Forbes, Hassan Rashidi
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Patent number: 11713449Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.Type: GrantFiled: April 21, 2021Date of Patent: August 1, 2023Assignee: Ths Trustees of the University of PennsylvaniaInventors: Martin Lock, Mauricio Alvira
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Patent number: 11713450Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.Type: GrantFiled: May 24, 2021Date of Patent: August 1, 2023Assignee: Ths Trustees of the University of PennsylvaniaInventors: Martin Lock, Mauricio Alvira
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Patent number: 11713451Abstract: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.Type: GrantFiled: October 29, 2020Date of Patent: August 1, 2023Assignee: Codexis, Inc.Inventors: Fabien Louis Cabirol, Haibin Chen, Anupam Gohel, Steven J. Collier, Derek J. Smith, Birgit Kosjek, Jacob Janey
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Patent number: 11713452Abstract: Certain embodiments are directed to modified or variant Cas9 proteins, and/or methods of using the same.Type: GrantFiled: September 10, 2018Date of Patent: August 1, 2023Assignee: UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTERInventors: Jin Liu, Zhicheng Zuo, Yu-Chieh Wang
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Patent number: 11713453Abstract: The invention concerns fusion proteins, wherein two endoglycosidases are fused, possibly via a linker. The fusion enzymes according to the invention have structure (1): EndoX-(L)p-EndoY (1), wherein EndoX is an endoglycosidase, EndoY is an endoglycosidase distinct from EndoX, L is a linker and p is 0 or 1. Such fusion enzymes capable of trimming glycoproteins comprising at least two distinct glycoforms in a single step. The invention further concerns the use of the fusion enzyme according to the invention for trimming glycoproteins. In another aspect, the invention relates to the process of production of the fusion enzyme. In a further aspect, the inventions concerns a process for trimming glycoproteins, comprising trimming the glycoprotein with a fusion enzyme according to the invention, to obtain a trimmed glycoprotein.Type: GrantFiled: December 7, 2020Date of Patent: August 1, 2023Assignee: SYNAFFIX B.V.Inventors: Remon Van Geel, Maria Antonia Wijdeven, Inge Catharina Josephina Hurkmans, Floris Louis Van Delft, Sander Sebastiaan Van Berkel
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Patent number: 11713454Abstract: The present invention provides a mutated histidine decarboxylase suitable for a practical use. Specifically, the present invention provides a mutated histidine decarboxylase having at least one amino acid residue mutated as compared to a wild-type histidine decarboxylase, and having higher histidine decarboxylase activity and/or stability than the wild-type histidine decarboxylase, and also a use thereof. The mutated histidine decarboxylase has Motifs (1) to (6), and an amino acid residue in at least one motif thereof can be mutated. The mutated histidine decarboxylase can also have a mutation of at least one amino acid residue in an amino acid sequence designated by SEQ ID NO: 3 and in a homologous sequence thereto.Type: GrantFiled: September 10, 2019Date of Patent: August 1, 2023Assignee: AJINOMOTO CO., INC.Inventors: Hiroki Yamaguchi, Masayuki Sugiki, Kunio Nakata
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Patent number: 11713455Abstract: For enhanced selection of efficient targeted genome manipulating agents, an apparatus includes first and second chip-based biosensors having one or more sensing surfaces configured to detect biomolecular binding interactions between a nucleic acid sample and a targeted genome manipulating agent functionalized to a capture surface within a sensing range of the one or more sensing surfaces. The first chip-based biosensor uses a nucleic acid sample incubated with a blocking agent that blocks on-target binding and the second chip-based biosensor holds a nucleic acid sample that omits the blocking agent. A measurement apparatus measures first and second sets of response signals produced in response to the biomolecular binding interactions occurring between the nucleic acid sample and the targeted genome manipulating agent. An analysis module determines the genome manipulating efficiency parameters of the targeted genome manipulating agent. A system and a method perform the functions of the apparatus.Type: GrantFiled: February 5, 2020Date of Patent: August 1, 2023Assignee: Cardea Bio, Inc.Inventors: Regis Peytavi, Kiana Aran, Brett Goldsmith, Alexander Kane
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Patent number: 11713456Abstract: The invention comprises methods for isolating nucleic acids, such as DNA and RNA, while enzyme-inhibiting polyanions are reduced at the same time, using a non-alcoholic binder solution that is not based on chaotropic salts, and a washing solution containing an amine compound, and kits suitable for such a method, comprising the mentioned binder solution and washing solution.Type: GrantFiled: April 8, 2021Date of Patent: August 1, 2023Assignee: AXAGARIUS GMBH & CO. KGInventor: Andreas von Bohl
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Patent number: 11713457Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.Type: GrantFiled: November 14, 2022Date of Patent: August 1, 2023Assignee: 10X GENOMICS, INC.Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov
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Patent number: 11713458Abstract: The present invention relates to a method of modifying at least one gene in a cell via CRISPR/Cas, wherein the at least one gene has at least three alleles. The present invention further relates to cells obtainable by the method of the invention. Additionally, the present invention provides a method of producing a protein in a cell obtainable by the method of modifying at least one gene of the invention. Moreover, the invention relates to proteins obtainable by the method of producing a protein and use thereof, for example in therapy.Type: GrantFiled: June 20, 2017Date of Patent: August 1, 2023Assignee: Octapharma AGInventors: Karina Nawrath, Janine Guendel, Sven Bahrke, Lars Stoeckl, Steffen Goletz
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Patent number: 11713459Abstract: Aspects of the invention described herein concern the incorporation of a FOXP3 cDNA (e.g., full-length human codon-optimized cDNA) into a FOXP3 gene or a non-FOXP3 locus so as to provide constitutive or regulated FOXP3 expression in a primary human CD34+ cells or cells derived from edited CD34+ cells. In some embodiments, guide RNA sequences that are directed to FOXP3, AAVS1, or other candidate loci are used for CRISPR/Cas9-mediated gene regulation, and gene delivery cassettes for HDR based gene-modification are provided.Type: GrantFiled: April 25, 2019Date of Patent: August 1, 2023Assignee: SEATTLE CHILDREN'S HOSPITALInventors: David J. Rawlings, Iram F. Khan, Yuchi Chiang Honaker, Swati Singh, Karen Sommer, Andrew M. Scharenberg
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Patent number: 11713460Abstract: This invention is in the field of molecular biology, gene expression, functional genomics, and bioinformatics and relates to novel RNA and related structures and methods of use thereof that enables modulation of gene expression and preservation of particular transcriptome targets. The invention contemplates various applications of RNA sequences derived from the genomic RNA of flaviviruses (FVs) and the application of such features in combination with heterologous sequences.Type: GrantFiled: February 11, 2021Date of Patent: August 1, 2023Assignee: The Regents of the University of ColoradoInventors: Jeffrey S. Kieft, Erich G. Chapman, David A. Costantino, Jay R. Hesselberth, Andrea MacFadden, Benjamin Akiyama
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Patent number: 11713461Abstract: The present disclosure provides methods of treating patients having decreased bone mineral density, methods of identifying subjects having increased risk of developing decreased bone mineral density, methods of detecting human Zinc And Ring Finger 3 (ZNRF3) variant nucleic acid molecules and variant polypeptides, and ZNRF3 variant nucleic acid molecules and variant polypeptides.Type: GrantFiled: June 22, 2020Date of Patent: August 1, 2023Assignees: Regeneran Pharmaceuticals, Inc., University of Maryland, BaltimoreInventors: Da-Wei Gong, Nehal Gosalia, Alan Shuldiner, Cristopher Van Hout, James Perry
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Patent number: 11713462Abstract: Provided herein are methods, compounds, and compositions for reducing expression of GYS1 in an individual. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a glycogen storage disease or disorder in an individual in need.Type: GrantFiled: December 23, 2021Date of Patent: August 1, 2023Assignees: Ionis Pharmaceuticals, Inc., The Hospital for Sick ChildrenInventors: Tamar R. Grossman, Susan M. Freier, Berge Minassian, Saija Ahonen
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Patent number: 11713463Abstract: Described herein are compositions and methods that are used to increase the expression of SCN2A, which may be used to treat neurological or psychiatric disorders. Antisense oligonucleotides that target upstream open reading frames (uORFs) may be administered to prevent translation initiation from a uORF to increase expression from a primary ORF (pORF), thus increasing the levels of SCN2A protein.Type: GrantFiled: January 17, 2019Date of Patent: August 1, 2023Assignee: The Florey Institute of Neuroscience and Mental HealthInventors: Steven Petrou, Eric G. Marcusson
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Patent number: 11713464Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.Type: GrantFiled: September 10, 2018Date of Patent: August 1, 2023Assignee: Duke UniversityInventors: Bruce A. Sullenger, Michael Goldstein, Elizabeth D. Pratico, Michael Kastan, Bethany Gray
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Patent number: 11713465Abstract: The present invention provides methods for the transformation of viable explants from wheat seeds to permit production of transgenic wheat plants. The present invention also relates to methods for producing such explants and related embodiments.Type: GrantFiled: November 21, 2014Date of Patent: August 1, 2023Assignee: MONSANTO TECHNOLOGY, LLCInventors: David R. Duncan, Sarah Heifner, David Kelm, Brian J. Martinell, Lorena Moeller, Anatoly Rivlin, Rebecca Rode, Xudong Ye, Ashok Shrawat, Yurong Chen
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Patent number: 11713466Abstract: Methods are provided to mutate, in a targeted manner, the genome of a plant cell using a double stranded DNA break inducing enzyme. Also provided are plants, in particular Brassica plants that yield seeds producing oils having a reduced total saturated fatty acid content, and method for making such plants.Type: GrantFiled: November 20, 2018Date of Patent: August 1, 2023Inventor: Meridith Kammerzell
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Patent number: 11713467Abstract: Provided are plasmid vector constructs encoding multiple immunomodulatory proteins where each protein or component thereof can be expressed utilizing appropriate promotors and/or translation modifiers. Additional immunomodulatory proteins and genetic adjuvants containing shared tumor antigens can be added to further therapeutic potential as well as allow tracking of therapeutic treatment. Also provides are methods of expressing the plasmid constructs.Type: GrantFiled: December 16, 2016Date of Patent: August 1, 2023Assignee: OncoSec Medical IncorporatedInventors: Jean Campbell, David A. Canton, Robert H. Pierce
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Patent number: 11713468Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel elements that further improve expression. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.Type: GrantFiled: August 2, 2018Date of Patent: August 1, 2023Assignee: DNA TWOPOINTO INC.Inventors: Jeremy Minshull, Maggie Lee
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Patent number: 11713469Abstract: Provided herein are adenoviral vectors comprising nucleotide sequences encoding a Zika virus M and Env antigen, wherein the nucleotide sequence encoding the Zika virus M and Env antigen is operably linked to a cytomegalovirus (CMV) promoter comprising at least one tetracycline operator (TetO) motif. Also provided herein are pharmaceutical compositions comprising the adenoviral vectors, methods of producing the adenoviral vectors, methods of preventing Zika virus or the progression of Zika virus in a subject in need thereof, and kits comprising the adenoviral vectors and host cells.Type: GrantFiled: July 19, 2019Date of Patent: August 1, 2023Assignee: Janssen Vaccines & Prevention B.V.Inventor: Taco Gilles Uil
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Patent number: 11713470Abstract: Provided herein are nucleic acids for expressing modified ligand-gated ion channel proteins in excitable cells or secretory cells, such as nerves and neurons and optionally including viral sequences, such as Adeno-associated virus sequences, for delivery to excitable cells or secretory cells of a patient. Also provided herein are methods of modulating cell membrane potentials in an excitable cell or secretory cell, and for treatment of a disease or disorder associated with the nervous system in a patient, such as chronic pain or itch.Type: GrantFiled: March 20, 2018Date of Patent: August 1, 2023Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Rebecca Seal, Cynthia Mary Arokiaraj
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Patent number: 11713471Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.Type: GrantFiled: March 28, 2022Date of Patent: August 1, 2023Assignee: METAGENOMI, INC.Inventors: Brian Thomas, Christopher Brown, Audra Devoto, Cristina Butterfield, Lisa Alexander, Daniela S. A. Goltsman, Justine Albers, Alan Brooks, Greg Cost, Morayma Temoche-Diaz, Cindy Castelle, Rebecca Lamothe
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Patent number: 11713472Abstract: Methods of RNA-guided DNA endonuclease-mediated genome editing in Bacteria and Archaea are provided.Type: GrantFiled: March 4, 2019Date of Patent: August 1, 2023Assignee: The Board of Trustees of the University of IllinoisInventors: William W. Metcalf, Dipti Dinkar Nayak
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Patent number: 11713473Abstract: The present disclosure discloses a process for accelerating, increasing, and stabilizing production of biogas with a high methane content in systems for biodigestion of organic waste. The process comprises: a) obtaining from an anaerobic biodigester (3) a fraction of organic waste equal in weight to K times the weight of the daily organic waste load of the anaerobic biodigester (3), wherein the parameter K is a numeric value selected between 10?3 and 10?1, sending the fraction to one or more acceleration devices (4), retaining the fraction in the one or more acceleration devices (4) until a final concentration (Cf) of the methanogenic bacteria in the fraction is equal to M times an initial concentration (Ci), wherein the parameter M is a numeric value selected between 103 and 108; b) as soon as said final concentration (Cf) is obtained in the fraction, directing said fraction from the acceleration device (4) back to the anaerobic biodigester (3); and c) successively repeating steps a) and b).Type: GrantFiled: July 1, 2021Date of Patent: August 1, 2023Assignees: G-Meta Consultoria, Participaçôes e Serviços LTDA, Bio-Tronic Energy Co. LLCInventor: Luciano Pesce
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Patent number: 11713474Abstract: Processes and systems for recovering products from a fermentation mash. In some examples, a process for recovering products from a fermentation mash can include processing a ground corn product to produce a fermentation mash that can include ethanol. At least a portion of the ethanol can be separated from the fermentation mash to produce a whole stillage. The whole stillage can be separated to produce a fiber rich product and a filtrate. The fiber rich product can be hydrolyzed to produce a saccharification mash. The saccharification mash can be processed to produce additional ethanol and a stillage protein product.Type: GrantFiled: February 18, 2022Date of Patent: August 1, 2023Assignee: POET GRAIN (OCTANE), LLCInventor: Jason Bootsma
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Patent number: 11713475Abstract: Disclosed are genetically engineered microbial cells for the production of oligosaccharides comprising a galactose-?1,4-glucose moiety at their reducing end, wherein said microbial cells are able to produce said oligosaccharides in the absence of exogenously added lactose, and a method of producing said oligosaccharides using said microbial cells.Type: GrantFiled: September 2, 2019Date of Patent: August 1, 2023Assignee: Chr. Hansen HMO GmbHInventors: Stefan Jennewein, Dirk Wartenberg, Katja Parschat
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Patent number: 11713476Abstract: The present invention relates to enzyme compositions for high temperature saccharification of cellulosic material and to uses thereof.Type: GrantFiled: July 12, 2021Date of Patent: August 1, 2023Assignee: NOVOZYMES, INC.Inventors: Brett McBrayer, Tarana Shaghasi, Elena Vlasenko
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Patent number: 11713477Abstract: The presently disclosed subject matter provides a process for starch liquefaction using at least two classes of ?-amylase enzymes, wherein the starch hydrolysis pattern from at least two of these classes is different. At least one class of enzyme is provided to the liquefaction process in the form of transgenic plant material expressing at least one class of ?-amylase enzyme or is provided in the form of a purified or partially-purified ?-amylase enzyme preparation. The second or subsequent class(es) of ?-amylase enzymes may be provided in the form of additional transgenic plant material expressing the second or subsequent class(es), or may be provided in the form of a second or subsequent purified or partially-purified ?-amylase enzyme preparation.Type: GrantFiled: August 24, 2021Date of Patent: August 1, 2023Assignee: Syngenta Participations AGInventor: George W. Aux
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Patent number: 11713478Abstract: The present disclosure relates to methods for characterizing and diagnosing dental diseases. In particular, the present disclosure relates to methods for characterizing and diagnosing dental disease (e.g., gingivitis and periodontal disease) based on levels of AI-2 in oral fluids and plaque.Type: GrantFiled: August 31, 2020Date of Patent: August 1, 2023Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, COLGATE-PALMOLIVE COMPANYInventors: Alexander Rickard, William Giannobile, Michelle Swetky, Nielson T. Baxter, Steven E. Miller, Laurence Du-Thumm, Hans Stettler
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Patent number: 11713479Abstract: A method for determining whether a test sample contains a phytopathogenic fungus, which includes (a) putting the test sample on a front surface of a substrate having a through hole; the substrate having a cellulose film on the back surface thereof; the through hole has a cross-sectional area of not less than 7.065 square micrometers and not more than 19.625 square micrometers; and the cellulose film has a thickness of not less than 0.5 micrometers and not more than 3.7 micrometers; (b) leaving the test sample at rest after the step (a); (c) irradiating the cellulose film with ultraviolet light after the step (b); (d) bringing a back surface of the cellulose film into contact with a fungus color reaction reagent after the step (c); and (e) determining that the test sample contains the phytopathogenic fungus, if a color is given to the fungus color reaction reagent.Type: GrantFiled: July 16, 2021Date of Patent: August 1, 2023Assignee: PANASONIC INTRILECTUAL PROPERTY MANAGEMENT CO., LTD.Inventors: Yuki Kushida, Yoshitsugu Uriu, Yosifumi Kariatumari
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Patent number: 11713480Abstract: The present disclosure relates to materials and methods for spatial detection of nucleic acid in a tissue sample or a portion thereof. In particular, provided herein are materials and methods for detecting RNA so as to obtain spatial information about the localization, distribution or expression of genes in a tissue sample. In some embodiments, the materials and methods provided herein enable detection of gene expression in a single cell.Type: GrantFiled: March 30, 2022Date of Patent: August 1, 2023Assignee: The Regents of the University of MichiganInventor: Jun Hee Lee
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Patent number: 11713481Abstract: A process for pre-concentration and detection of at least one single-stranded nucleic acid target molecule, the process comprising the steps of generating a flow of liquid comprising at least one magnetic nanoparticle in a micro-channel and a plurality of single-stranded nucleic acid probe molecules attached to the nanoparticle, generating an alternating magnetic field in the part of the micro-channel using an electromagnet, the magnetic field having an intensity and frequency that are suitable for causing magnetic hyperthermia of the nanoparticles so as to cause denaturing of the duplex formed by the single-stranded nucleic acid target molecule and the single-stranded nucleic acid probe molecule, and detecting the single-stranded target molecule dispersed in the liquid.Type: GrantFiled: October 5, 2018Date of Patent: August 1, 2023Assignees: Centre National de la Recherche Scientifique (CNRS), Institut National de La Sante et de la Recherche Medicale (INSERM), Sorbonne UniversiteInventors: Marie-Charlotte Horny, Jean-Michel Siaugue, Vincent Dupuis, Mathieu Lazerges, Jean Gamby
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Patent number: 11713482Abstract: Disclosed herein are methods, devices and compositions comprising nucleic acid captor molecules with a stem region and a loop region for detecting target nucleic acids.Type: GrantFiled: June 15, 2017Date of Patent: August 1, 2023Assignee: GENECAPTURE, INC.Inventors: Paula M. Koelle, Krishnan Chittur, Valentin Korman, Zachary McGee
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Patent number: 11713483Abstract: Provided herein are products and methods for detecting analytes using polymers that bind to such analytes and thereby undergo a conformational change or contribute to a newly formed complex.Type: GrantFiled: February 8, 2017Date of Patent: August 1, 2023Assignee: Children's Medical Center CorporationInventors: Wesley Philip Wong, Clinton H. Hansen
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Patent number: 11713484Abstract: Providing herein, among other things, is a method comprising incubating a double-stranded nucleic acid having a nick with a nick translating activity, a ligase, and a nucleotide mix comprising at least one modified nucleotide, to generate a product comprising a patch of a newly synthesized strand of a duplex nucleic acid containing a plurality of modified nucleoside monophosphates that are at or adjacent to the site of the nick. In some embodiments, the method may be used to map damaged nucleoside monophosphates in a nucleic acid. Compositions and kits for use in performing the method are also provided.Type: GrantFiled: August 21, 2018Date of Patent: August 1, 2023Inventors: Kelly M. Zatopek, Vladimir Potapov, Jennifer Ong, Laurence Ettwiller, Lixin Chen, Thomas C. Evans, Jr., Andrew F. Gardner
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Patent number: 11713485Abstract: The disclosure provides a method for detecting a target analyte in a biological sample including contacting the sample with one or more probe sets each comprising a primary probe and a linker, contacting the sample with an initiator sequence, contacting the sample with a plurality of fluorescent DNA hairpins, wherein the probe binds the target molecule, the linker connects the probe to the initiator sequence, and wherein the initiator sequence nucleates with the cognate hairpin and triggers self-assembly of tethered fluorescent amplification polymers, and detecting the target molecule by measuring fluorescent signal of the sample.Type: GrantFiled: August 3, 2021Date of Patent: August 1, 2023Assignee: President and Fellows of Harvard CollegeInventors: Evan R. Daugharthy, George M. Church
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Patent number: 11713486Abstract: The present invention provides combinations of biomarkers that can be used in the diagnosis and differentiation of bipolar disorder and schizophrenia. The present invention therefore provides methods of differentiating, diagnosing and treating bipolar disorder and schizophrenia, by examining relevant proteins and RNA in a patient sample.Type: GrantFiled: September 15, 2017Date of Patent: August 1, 2023Assignees: The Regents of the University of California, Laguna Diagnostics, LLCInventors: Terry W. Osborn, Marquis Vawter
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Patent number: 11713487Abstract: In the field of transplant rejection, identified are SNPs wherein mismatches in variants present in a recipient and donor for such SNPs are predictive of transplant outcome, wherein the SNPs represent non-HLA loci newly implicated in rejection. By the invention, transplant outcomes such as elevated risk of antibody mediated rejection, elevated risk of T-cell mediated rejection, or low risk of rejection can be predicted by analyzing mismatches between donor and recipient for the enumerated SNPs. Certain SNPs enumerated are predictive of kidney transplant outcome. The compatibility of prospective donors can be assessed for a recipient, allowing for optimized donor-recipient pairing.Type: GrantFiled: July 16, 2018Date of Patent: August 1, 2023Assignee: The Regents of the University of CaliforniaInventors: Minnie Sarwal, Marina Sirota, Silvia San Juan Pineda
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Patent number: 11713488Abstract: The present invention generally relates to the field of cancer, in particular to cancers having microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency. Examples of such cancers include many colorectal, gastric, and endometrial tumors. Accordingly, the present invention provides a novel diagnostic marker panel for analyzing MSI loci, together with methods and kits of using said panel in the detection of cancers having microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency.Type: GrantFiled: January 22, 2019Date of Patent: August 1, 2023Assignee: BIOCARTIS NVInventors: Bram De Craene, Klaas Decanniere, Jan Van De Velde, Geert Maertens
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Patent number: 11713489Abstract: Embodiments of present disclosure are directed to methods for amplifying nucleic acid, comprising two steps: a first step of preparing a reaction mixture comprising the target nucleic acid and a second step of processing the reaction mixture in a thermocycler. During a first phase of the processing step, the thermocycler may be configured to heat the reaction mixture to a first temperature and cool the reaction mixture to a second temperature repeatedly for a first plurality of cycles. During the first phase, fluorescence probes do not anneal to template strands and do not emit fluorescence signals. During a second phase of the processing step, the thermocycler may heat the reaction mixture to a third temperature and cool the reaction mixture to a fourth temperature repeatedly for a second plurality of cycles.Type: GrantFiled: October 26, 2020Date of Patent: August 1, 2023Assignee: Tetracore, Inc.Inventors: William M. Nelson, Kyle Armantrout, Tracy Calvin Fecteau
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Patent number: 11713490Abstract: A method for identifying a quantitative trait locus associated with desirable nutritional traits in canola includes: analyzing a population of canola plants or germplasm for desirable nutritional traits; determining the genotype of the canola plants or germplasm using at least one marker selected from the group consisting of SEQ ID NO:1 through SEQ ID NO:111; mapping the canola plants or germplasm for the presence of a quantitative trait locus (QTL) associated with the markers; and associating the QTL with the desirable nutritional trait. An isolated and/or recombinant nucleic acid includes a sequence associated with a quantitative trait locus (QTL), wherein the QTL is associated with a desirable nutritional trait in a canola plant or germplasm and wherein the QTL is further associated with at least one marker selected from the group consisting of SEQ ID NO:1 through SEQ ID NO:111.Type: GrantFiled: October 6, 2020Date of Patent: August 1, 2023Assignee: CORTEVA AGRISCIENCE LLCInventors: Shunxue Tang, Van L. Ripley, Thomas G. Patterson, Michelle Wiggins, Joshua A. Flook, Cherie Ochsenfeld, Daniel Garcia, Syed Masood Rizvi, Ryan Preuss, Donna Carolynn Knievel, Zoe Christina Ehlert, Steve Rounsley, Muhammad Tahir
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Patent number: 11713491Abstract: Provided herein is a nucleotide cassette comprising an inducible promoter, a nucleotide sequence that corresponds to at least one single stranded RNA diagnostic target, a nucleotide sequence that encodes artemin, a molecular switch and a nucleotide sequence that encodes a DNAse enzyme and is under control of the molecular switch, wherein the single stranded RNA diagnostic target is a sequence detected by a molecular diagnostic assay. In some embodiments the nucleotide cassette can be used to obtain an RNA expression product. Also provided are vectors and cells comprising the nucleotide cassette or the RNA expression product thereof. The nucleotide cassette can further be used to obtain a diagnostic control composition comprising a non-pathogenic recombinant bacterium having a modified genetic content comprising the nucleotide cassette and to methods of producing such recombinant bacteria.Type: GrantFiled: April 23, 2021Date of Patent: August 1, 2023Assignee: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURGInventors: Bavesh Davandara Kana, Edith Erika Machowski
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Patent number: 11713492Abstract: A roller chain having at least one pair of offset links wherein the offset link plates are made with a steel having a high chromium content and are through-hardened using an austempering heat treatment (such as a salt bath quench). The resulting offset link plates may have a hardness in range of 44-50 HRC on the Rockwell hardness scale and a bainite metallurgical microstructure. The offset link plates may also have a greater fatigue strength than at least one of the inner link plates and the outer link plates. The inner and outer link plates may be formed out of a plain carbon steel which is heated, quenched and tempered to produce a martensite microstructure.Type: GrantFiled: May 20, 2020Date of Patent: August 1, 2023Assignee: Iwis Drive Systems, LLCInventor: Andrew J. Binford
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Patent number: 11713493Abstract: This disclosure provides engineered microbes coding at least one rare earth element (REE) binding ligand for the preferential separation of REEs, as well as methods of use thereof.Type: GrantFiled: February 28, 2019Date of Patent: August 1, 2023Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Dan Mcfarland Park, Aaron William Brewer, Yongqin Jiao
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Patent number: 11713494Abstract: Provided are processes for extracting lithium and optionally nickel from a Nickel(II)/Lithium(I) (Ni2+/Li+) solution. The extraction is optionally performed in a series of steps with counterflow of aqueous and organic flows to thereby produce a lithium poor solution. The lithium poor solution may be treated so that remaining Ni in the lithium poor solution may be directly precipitated therefrom in the form of a Ni salt. Once complete, the process provides for recoverable nickel and/or lithium that may be recycled into batteries or sold for other uses.Type: GrantFiled: November 4, 2020Date of Patent: August 1, 2023Assignee: BASF CorporationInventors: Jack Bender, William C. Mays, Tinoush Dinn, Martin L. Panchula, Dieter G. Von Deak
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Patent number: 11713495Abstract: A tantalum or tantalum alloy which contains pure or substantially pure tantalum and at least one metal element selected from the group consisting of Ru, Rh, Pd, Os, Ir, Pt, Mo, W and Re to form a tantalum alloy that is resistant to aqueous corrosion. The invention also relates to the process of preparing the tantalum alloy.Type: GrantFiled: April 12, 2021Date of Patent: August 1, 2023Assignee: Materion Newton Inc.Inventors: Paul R. Aimone, Evan Hinshaw