Abstract: One aspect of the present disclosure provides a production method for a composite, the method including: a cooling step of performing cooling under a pressurized condition in a state where a heated molten material of a thermosetting composition is brought into contact with a resin-impregnated body, in which the above-described resin-impregnated body includes a nitride sintered body having a porous structure and a semi-cured product of the thermosetting composition impregnated into the above-described nitride sintered body.

Abstract: According to some embodiments, there is provided herein a granule comprising polyhalite and phosphate rock, in a ratio of between 30:70 to 70:30, respectively.

Abstract: Soil treatment compositions, products, systems, kits, and methods, for increasing the amount, level, ratio, or proportion of soluble and/or bioavailable phosphorus in soil, for solubilizing phosphorus, for enhancing or improving bioavailability of phosphorus in soil, for improving soil fertility, for increasing crop production, for reducing phosphorus fertilizer requirements, and so forth. Bioactivated fertilizer compositions and related methods for increasing phosphorus solubility and/or bioavailability in soil.

Abstract: A composition including at least about 50 wt% basalt and no more than about 20 wt% binding agent, wherein the composition is in the form of a plurality of particles. The composition can find applications in agriculture, horticulture, and gardening, and can be used, e.g., as soil amendment.

Abstract: A micronutrient formulation includes (i) a biochelant; (ii) a micronutrient salt; (iii) a ring opener; and (iv) a solvent. A micronutrient formulation includes a sugar oxidation product, a ring opener, a micronutrient salt and a solvent. The micronutrient formulation has a sodium ion concentration of from about 1,000 ppm to about 99,000 ppm.

Abstract: An Arthrobacter pascens X-1 for promoting a growth of nodules and increasing an abundance of probiotic microorganism populations is disclosed. After the Arthrobacter pascens X-1 provided by the disclosure is applied, nutrient elements required by plants such as potassium, calcium and magnesium in rock powder are effectively released, rock erosion is accelerated to form soil, simultaneously effective nitrogen fixation of soybeans is promoted, nitrogen required for soybean growth is provided, symbiotic nitrogen fixation capability of rhizobium and host plants is obviously exerted, total weight of root nodules is promoted to be increased by 150.00%, content of hydrolyzed nitrogen is improved to be increased by 11.58%, and symbiotic nitrogen fixation capability is effectively exerted. At the same time, the relative abundance of Bradyrhizobium in the soil is increased from 0.21% to 52.47%.

Abstract: The invention relates to a composting device for providing compost material from organic material, comprising a drying chamber for receiving organic material to be composted, a heating device located on the drying chamber for heating the organic material located in the drying chamber, a control device for controlling and/or regulating the heating device, and a composting chamber, which is connected to the drying chamber via an opening for material transfer and in which the organic material that has been dried in the drying chamber can be converted into compost material. The invention further relates to a method for providing compost material.

Abstract: Methods for producing solid acidic fertilizer granules, solid acidic fertilizer granules, and methods for their use in fertigation, are disclosed. The method can include providing a plant nutrient containing nitrogen (N), phosphorus (P) and optionally potassium (K), in a container; feeding an acid solution containing an inorganic acid into the container at a feeding rate comprising an average feed rate of 0.2 to 0.8 metric ton of the inorganic acid (MTacid) per hour per metric ton of the plant nutrient (MTnutrient) (MT acid.h?1.MT nutrient?1) and contacting the inorganic acid and the plant nutrient to obtain acidified granules with average moisture content of 0.5 wt. % to 1.0 wt. %; and drying the acidified granules to obtained dried acidic granules.

Abstract: The present invention relates to a fertilizer in granular form comprising within the same granule a mixture of: (A) From 15 to 85 wt % of a potassium sulfate; and (B) From 85 to 15 wt % of at least one salt that is different from (A) and that provides potassium and/or magnesium and/or calcium and/or sulfate; wherein the fertilizer in granular form has—a potassium level (expressed as K2O) of at least 18 wt %, preferably at least 20 wt %;—a chloride level of at most 10 wt %, preferably at most 5 wt %, more preferably at most 3 wt %;—a magnesium level (expressed as MgO) of at most 10 wt %, preferably at most 9.5 wt %. Materials of the invention are free flowing & combine a good nutrient balance with a good hardness and wear resistance.

Abstract: Provided is a gas-generating agent composition containing the components (a) to (d) below, in which a content of the following (d) calcium carbonate is 5 mass % or less: (a) guanidine nitrate; (b) a basic metal nitrate; (c) a binder; and (d) calcium carbonate.

Abstract: The invention relates to a process for oligomerization of ethylene, preferably for selective trimerization of ethylene to hex-1-ene, comprising simultaneously bringing ethylene into contact with the components of a catalytic composition based on chromium.

Abstract: The disclosure relates to a process to perform an endothermic methane pyrolysis reaction, said process comprising the steps of providing at least one fluidized bed reactor comprising at least two electrodes; and a bed comprising particles, wherein the particles are put in a fluidized state by passing upwardly through the said bed a fluid stream, to obtain a fluidized bed; heating the fluidized bed to a temperature ranging from 500° C. to 1200° C. to conduct the endothermic methane pyrolysis reaction; wherein the particles of the bed comprise electrically conductive particles and particles of a catalytic composition; wherein at least 10 wt. % of the particles are electrically conductive particles and have a resistivity ranging from 0.001 Ohm·cm to 500 Ohm·cm at 800° C. and wherein the step of heating the fluidized bed is performed by passing an electric current through the fluidized bed.

Abstract: The disclosure relates to a process to perform a catalytic cracking reaction of hydrocarbons having at least four carbons, said process comprising the steps of providing a fluidized bed reactor comprising at least two electrodes and a bed comprising particles, wherein the particles are put in a fluidized state to obtain a fluidized bed; heating said bed to a temperature between 500° C. and 850° C. by passing an electric current through the fluidized bed to conduct the reaction. The process is remarkable in that the particles of the bed comprise electrically conductive particles and particles of a catalytic composition, wherein at least 10 wt. % of the particles are electrically conductive particles and have a resistivity from 0.001 to 500 Ohm.cm at 500° C. and in that the step of heating the fluidized bed is performed by passing an electric current through the fluidized bed.

Abstract: Provided is a method for producing a deuterated aromatic compound and a deuterated reaction composition. The method includes performing a deuterated reaction of an aromatic compound including one or more hydrocarbon aromatic rings using a solution comprising heavy water, an organic compound which can be hydrolyzed by the heavy water, the aromatic compound, and an organic solvent. The method has an advantage in that impurities due to hydrogen gas are not generated, the deuterium substitution rate is high, and the deuterated reaction can be performed under a lower pressure and a lower temperature.

Abstract: The present invention relates to a process for producing alcohols by hydrogenation of C13 aldehydes. The process according to the invention is performed in two consecutive hydrogenation stages, wherein the first hydrogenation stage employs an activated metal catalyst based on a nickel metal foam and the second stage employs a supported catalyst containing a catalytically active component from the group consisting of nickel, copper, chromium and mixtures thereof.

Abstract: The present invention relates to a process for producing alcohols by hydrogenation of C4 to C20 aldehydes. The process according to the invention is performed in two consecutive hydrogenation stages, wherein the first hydrogenation stage employs an activated metal catalyst based on a nickel metal foam and the second stage employs a supported catalyst containing a catalytically active component from the group consisting of nickel, copper, chromium and mixtures thereof.

Abstract: The present invention relates to a process for producing alcohols by hydrogenation of C9 aldehydes. The process according to the invention is performed in two consecutive hydrogenation stages, wherein the first hydrogenation stage employs an activated metal catalyst based on a nickel metal foam and the second stage employs a supported catalyst containing a catalytically active component from the group consisting of nickel, copper, chromium and mixtures thereof.

Abstract: Steam reforming, water separation, and hydrogen separation by membrane can be performed sequentially on a mixture of steam and a hydrocarbon. A hydrogen-rich permeate stream from the hydrogen membrane can be used as fuel for combustion heating, leaving a retentate mixture of a prescribed ratio of hydrogen to oxides of carbon. The retentate can be compressed and synthesized to methanol in a methanol synthesis reactor. The synthesized methanol can be separated into a methanol-rich stream and a tail gas stream containing the remaining outlet gas from the synthesis reactor. The methanol-rich stream can be refined. The tail gas stream can be divided into a methanol loop recycle stream, an SMR recycle stream, and a nitrogen purge stream. The methanol loop recycle stream is compressed and recycled to the methanol synthesis reactor. The SMR recycle stream is recycled as feedstock to the reformer. The nitrogen purge stream is combusted in a burner.

Abstract: A process for producing isomerized olefins, branched aldehydes, branched alcohols and branched surfactants through isomerization, hydroformylation, hydrogenation and surfactant forming reactions.

Abstract: Systems and methods for producing MTBE without using a catalytic distillation column or a super fractionator have been disclosed. An optimum volume of methanol stream required to maximize MTBE production and reduce slippage of isobutylene to minimum acceptable values together with a crude C4 stream are flowed into a primary reaction unit that comprises a first reactor and a second reactor in parallel configured to produce maximum values of final MTBE volumes under higher or equal established purity commercial quality specifications levels. The combined effluent from the first reactor and the second reactor is split to form a first portion, a second portion and a third portion. The first portion is flowed to a third reactor configured to produce additional MTBE. The second portion is combined with an effluent from the third reactor for further separation. The third portion is recycled to the first reactor and/or second reactor.

Abstract: Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic oxidation, a reduction reaction, performing an acid-catalyzed coupling reaction, a methylation reaction and a deprotection reaction. Disclosed herein are methods, processes and compositions for enantioselectively preparing compounds of formulae 8 and 18. Also disclosed herein are compositions comprising compounds of formulae 8, 18 and/or intermediates and/or starting material thereof.

Abstract: The present invention relates to a process for separating 1-methoxypropan-2-ol in a stream S3 from an aqueous stream comprising 1-methoxypropan-2-ol and 2-methoxypropan-1-ol, wherein the process comprises providing a stream S0 comprising 1-methoxypropan-2-ol, 2-methoxypro-pan-1-ol and water, and having a molar ratio of 1-methoxypropan-2-ol:2-methoxypropan-1-ol in the range of from 1:5 to 5:1. A further aspect of the invention also relates to 1-methoxypropan-2-ol obtained or obtainable from said process, as well as to a mixture of 1-methoxypropan-2-ol and 2-methoxypropan-1-ol, preferably obtained or obtainable from said process, which preferably comprises in the range of from 95 to 100 weight-% 1-methoxypropan-2-ol and ?0.5 weight-% of 2-methoxypropan-1-ol, each based on the total weight of the mixture.

Abstract: A process for the production of formaldehyde from methanol comprising the steps of: feeding to a reactor a feed stream comprising the methanol and an oxygen-containing gas; reacting the methanol in the gas phase with the oxygen-containing gas in the reactor in the presence of a catalyst comprising oxides of iron and molybdenum; and recovering a formaldehyde reactor outlet stream from the reactor, the formaldehyde reactor outlet stream comprising formaldehyde and carbon monoxide. The catalyst comprises copper in an amount of at least 0.025 wt %, or at least 0.05 wt %, of the catalyst and in that the molar ratio of carbon monoxide to formaldehyde in the formaldehyde reactor outlet stream is at least 5% less than the molar ratio of carbon monoxide to formaldehyde in the formaldehyde reactor outlet stream in the same process using a catalyst containing essentially no copper.

Abstract: The present invention relates to the field of perfumery. More particularly, it concerns valuable new chemical intermediates for producing perfuming ingredients. Moreover, the present invention also comprises a process for producing compound of formula (I).

Abstract: Disclosed is a method of purification of utilized acetylation fluid recovered from a process of acetylating wood. The method involves subjecting the recovered acetylation fluid to cooling crystallization. By this method terpene and terpenoid impurities are removed, as well as other impurities. Disclosed is also a method of acetylating wood resulting in acetylated wood and utilized acetylation fluid comprising acetic acid, and purifying the utilized acetylation fluid by cooling crystallization.

Abstract: A method for producing an a-hydroxycarboxylic acid compositions includes distilling a mixed solution containing an ?-hydroxycarboxylic acid, water, and an organic impurity, wherein the distillation is performed under a condition that an upper limit temperature of a bottoms liquid is 140° C. or lower.

Abstract: The present application relates to a process for producing acrylic acid.

Abstract: The invention relates to oleoyl-lysophosphatidylinositol (oleoyl-LPI) and new synthetic derivatives thereof and uses thereof, and to pharmaceutical compositions comprising such compounds. The invention provides activators and/or up-regulators of glucoregulatory hormones such as glucagon like peptide-1 (GLP-1), and more specifically to agonists, partial agonists and reverse antagonists of GPR119 or activators of GLP-1 activity and/or synthesis and/or secretion, and pharmaceutical compositions comprising same, uses thereof in therapy of diabetes, obesity and other metabolic disorders.

Abstract: The invention relates to a method for preparing a suspension of a hydrochloride of an organic amine, comprising the following steps of (i) initially charging at least one organic solvent in a reaction vessel to form a liquid level, (ii) adding hydrogen chloride, (iii) adding the organic amine, wherein the organic amine is added below the liquid level present in the reaction vessel and steps (ii) and (iii) are at least partly carried out simultaneously. Furthermore, the present invention also relates to a method wherein the suspension obtained after step (iii) is reacted in a step (iv) with phosgene to obtain the organic isocyanate corresponding to the organic amine used, to the corresponding organic isocyanate and to the use of the organic isocyanate for producing polyisocyanates.

Abstract: In some embodiments, the present disclosure provides amino acid compounds that are useful for producing products such as peptides. In some embodiments, the present disclosure provides peptides comprising residues of provided amino acids.

Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof and pharmaceutical composition comprising the compound of formula (I). The present composition also relates to methods treating a disease or disorder associated with ubiquitin-specific protease 28 (USP28), methods of treating cancer, and methods of inhibiting USP28.

Abstract: The present invention belongs to the field of agricultural acaricides, and particularly relates to a substituted phenyl sulfide compound and an application thereof. The substituted phenyl sulfide compound is as represented in general formula I. Definitions of substituted groups in the formula are given in the description. The compound of the general formula I has excellent acaricidal activity and can be used for preventing and controlling various mites.

Abstract: The present invention relates to a process for producing specific ?,?-unsaturated carboxylates.

Abstract: A process of manufacturing of (2S,5R)-5-(2-chlorophenyl)-1-(2?-methoxy-[1,1?-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid (1), including the preparation of (2S,5R)-methyl 5-(2-chlorophenyl)pyrrolidine-2-carboxylate hydrochloride (6·HCl) as an intermediate of synthesis: Also, the sodium salt of the (2S,5R)-5-(2-chlorophenyl)-1-(2?-methoxy-[1,1?-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid (1), and its use in a pharmaceutical composition including sodium the (2S,5R)-5-(2-chlorophenyl)-1-(2?-methoxy-[1,1?-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylate and a method for treating and/or preventing inflammation in a patient.

Abstract: The present disclosure relates to crystalline forms of N-{3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-allylidene}-aminoguanidinium salts having high solubility. The disclosure also relates to use of said crystalline forms in medicine.

Abstract: The presently disclosed subject matter provides compositions, kits, and methods comprising imaging agents that can detect Programmed Cell Death Ligand 1 (PD-L1). The presently disclosed imaging agents can be used to detect diseases and disorders, such as cancer, infection, and inflammation, in a subject.

Abstract: The present invention is directed to novel chemical compositions of matter and their methods of synthesis, and in particular novel analogs of Psilocin having enhanced physical and pharmacokinetic characteristics.

Abstract: The present invention relates to a novel TNF activity inhibitor compound and a pharmaceutically acceptable salt thereof, a method for prevention, alleviation or treatment comprising administering the compound of the present invention, a method for preparing the compound of the present invention, and a pharmaceutical composition comprising the compound.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Abstract: The present disclosure relates to crystalline form CS1 and CS9 of a hypoxia-inducible factor prolyl hydroxylase inhibitor compound (I) GSK1278863, processes for preparation, and uses for preparing drugs treating and/or preventing anemia thereof.

Abstract: The disclosure provides a naphthylurea compound having a formula I. R represents H, a C1-C5 straight-chain alkyl, a C1-C5 straight-chain alkyl with a halogen-substituted end or a 5-8-membered cycloalkyl; R1, R2, R3, R4, R5, R6, R7, R8, R9 at each occurrence represent H, F, Cl, Br, —CN, —CH3, —CF3, —OCH3, or —OCF3; R5 optionally represents phenyl, and M is H or —CH3; m represents a number of CH2, and is 0 or 1; n represents a number of CH2, and is 1, 2, 3, or 4; and p represents a number of CH2, and is 2; and X is O or S.

Abstract: A method by which an intermediate product of an azole derivative can be produced at a lower cost than known production methods is provided. A method for producing a compound represented by General Formula (IV) includes converting a compound represented by General Formula (II) into the compound represented by General Formula (IV) using (a) dimethyl sulfide and/or dimethyl sulfoxide, and (b) a methyl-LG (an LG is a nucleophilically substitutable leaving group and is selected from the group consisting of a halogen group, an alkoxysulfonyloxy group, an aryloxysulfonyloxy group, an alkylsulfonyloxy group, a haloalkylsulfonyloxy group, and an arylsulfonyloxy group) in the presence of an inorganic base.

Abstract: Processes are described for obtaining highly purified tetrahydrocannabinolic acid (THCa) from Cannabis. Solvent extraction is performed on plant material or extract, followed by removal of impurities using sequential liquid-liquid extractions to purify cannabinoid carboxylic acids therefrom based on chemical properties of carboxylate salts. The product liquor, comprising THCa in solvent, is largely free of impurities, and high in THCa. Further steps can be conducted to obtain a highly enriched solution using chromatography and subsequent crystallization of THCa in 99% purity. THCa can be used as starting material for other products that include THC by decarboxylation. Optionally, triglyceride extraction of a washed aqueous phase can be used to prepare a THCa composition without chromatographic purification. A pre-processing aqueous extraction with pH manipulations may be used to remove biomass prior to solvent extraction, while maintaining THCa and optionally other cannabinoid acids.

Abstract: The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a diseases a sole agent or in combination with other active ingredients.

Abstract: Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) are useful for activating uncoupling protein 1 (UCP1) dependent thermogenesis. Also disclosed herein are methods of treating obesity or metabolic disorders such as diabetes using a compound of Formula (I).

Abstract: The present invention relates to heterocyclic compounds as immunomodulators, or pharmaceutically acceptable salts thereof. Specifically, the present invention relates to compounds as represented by general formula (I) and pharmaceutically acceptable salts thereof. The present invention also relates to methods for preparing the compounds or the pharmaceutically acceptable salts thereof. The compounds can be used for treating and/or preventing tumors, inflammations or immune diseases.

Abstract: The present invention relates to the processes for the preparation of substituted pyrazole derivatives of formula (I), (II), (III), (IV), (IV-a) (V), (VII), which are useful as intermediates in anthranilamide insecticides production. In addition, the present invention is directed to a method for the preparation of anthranilamides of formula (VIII) using substituted pyrazole derivatives of formula (I), (III), (IV), (V), (VII). Furthermore, the present invention is directed to substituted halo-pyrazole compounds of formula (III), (IV) and (V), wherein X is halogen and R7 is hydrogen, C1-C4 alkyl.

Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.

Abstract: An EGFR inhibitor having the structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, a use of same as an EGFR inhibitor, and a use of same in preparing a drug for treating and/or preventing a cancer, a tumor, or a metastatic disease at least partially related to an EGFR exon 20 insertion, deletion, or other mutation, and in particular a use in preparing a drug for treating and/or preventing a hyperproliferative disease and an induced cell death disorder. Each substituent of formula (I) has the same definition as in the description.

Abstract: Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.