Abstract: A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.

Abstract: A method of making a biocompatible composition for sealing tissue includes mixing a first fluid having a first reactive component (e.g., an electrophile) and a second fluid having a second reactive component (e.g., a nucleophile) to form a mixture and expressing the mixture. During expression, a pH modifying fluid (e.g., NaOH) is added to the mixture at a rate that changes. In one embodiment, a higher ratio of the pH modifying fluid is added to the mixture during a first expressing stage and a lower ratio of said pH modifying fluid is added to the mixture during a second expressing stage. During the first expressing stage, a mixing ratio of the pH modifying fluid, the first fluid and the second fluid is 0.7-1.4:1:1. During the second expressing stage, the mixing ratio of the pH modifying fluid, the first fluid and the second fluid is 0.12-0.24:1:1.

Abstract: The present invention relates to compositions suitable for the delivery of agents to biological targets such as tissues and cells and/or capable of promoting the growth and/or proliferation of cells, and methods for the production thereof. Specifically, a printable collagen bioink comprising type IV collagen is used to produce crosslinked collagen gels comprising mammalian cells, such as endothelial or epithelial cells, for corneal regeneration.

Abstract: The present invention provides an injectable scaffold comprising a plurality of unclad microfibers, and a diluent solution.

Abstract: A method for producing macroporous scaffolds which are useful in bone generation is provided. A liquid phase which is an aqueous solution of a non-denatured silk protein is subjected to mechanical foaming. A mineral phase comprising ?-tricalcium phosphate (?-TCP) with hydroxyapatite (HA) is blended into the foamed liquid phase during continued mechanical foaming, thereby forming a macroporous paste. The macroporous paste is stabilized into a desired shape. The stabilized, shaped porous paste is mineralized into a macroporous calcium-deficient hydroxyapatite (CDHA)-based scaffold.

Abstract: Presented herein are devices, systems, and methods related to liquid infused substrates for use in medical applications. Adhesion of proteins, pathogens, and other substances to medical devices presents an issue. Proteins from the surrounding environment adhere to medical devices, which may, under certain conditions, result in the adhesion of pathogens to the medical device. The presence of these pathogens may result in infections when a medical device is inserted or otherwise placed in vivo (in whole or in part), which may require the removal of the device and/or treatment of the subject with antibiotics. Changing the surface properties of such devices can alter which proteins, pathogens, and/or other substances adhere and/or adsorb to the surface. Accordingly, in some embodiments, the present disclosure provides for technologies for altering surface adhesion and/or absorption of proteins, pathogens and/or other substances by infusing/impregnating a substrate of the device with an impregnation fluid.

Abstract: Provided are a valve member and a milking machine-EH that are easy to wash. The valve member enables an internal passage to temporarily retain milk when the milking machine is in a negative pressure state, and enables the milk retained in the internal passage to be discharged when the milking machine is in a normal pressure state. The valve member is provided with a cap that is attached to the milking machine. The cap is provided with a partition wall that separates a first space on the milk inflow side and a second space on the milk outflow side. A through hole in the partition wall allows communication between the first space and the second space. A valve body disposed in the second space closes the through hole when the negative pressure state is established, and opens the through hole when the normal pressure state is established.

Abstract: Breast pumps allow for increased milk volume flow rates and/or increased pump efficiency. Various devices and techniques are used to introduce a more diverse set of vibration patterns which enable users to customize the performance of the vibration and/or enable vibrations to be present or absent in ways not currently enabled by the state of the art. This can involve applying vibrations to the breast during the breast pump cycle (or “waveform”), to increase the volume flow rate of expressed milk for a given cycle speed and suction level.

Abstract: A breast pump comprises an expression system. Audible and/or tactile feedback is generated for a user of the breast pump by controlling the expression system.

Abstract: A medical apparatus comprises a medical machine and a manifold assembly mounted or mountable on the medical machine. The medical machine comprises an occlusion element comprising a plunger configured to be moved between a retracted position, in which the plunger is spaced from a soft membrane of the manifold and a port of the manifold is open, and a forward position, in which the plunger accommodated in a seat of the port and the soft membrane is trapped between the plunger and the seat to close the port. The occlusion element comprises a membrane tensioner of mechanical type. The membrane tensioner is configured to raise the soft membrane away from the seat when the plunger goes back to the retracted position and to counteract a possible negative pressure tending to keep the port closed.

Abstract: An extracorporeal blood treatment system including a blood oxygenator having an inlet for receiving deoxygenated blood and an outlet for expelling oxygenated blood. The system also includes a recirculation flow path for recirculating a portion of the oxygenated blood exiting the oxygenator outlet back into the oxygenator inlet. The system may also include a dual-lumen cannula coupled to the oxygenator. The cannula includes a manifold with a first blood pathway communicating with the oxygenator outlet, a second blood pathway communicating with the oxygenator inlet, and a third blood pathway connecting the first blood pathway to the second blood pathway. The manifold passes oxygenated blood received from the oxygenator through the first blood pathway, passes deoxygenated blood received from the patient through the second blood pathway, and passes a portion of the oxygenated blood from the first blood pathway through the third blood pathway to be combined with deoxygenated blood in the second blood pathway.

Abstract: The present invention relates to a membrane gas exchanger having a housing in which a first chamber and a second chamber as well as a membrane are arranged, wherein the membrane is gas permeable and liquid impermeable and separates the first chamber and the second chamber from one another, wherein the first chamber forms the blood side and the second chamber forms the gas side of the membrane gas exchanger, and wherein the first chamber has a blood inlet and a blood outlet, and wherein the second chamber has a gas inlet and a gas outlet, and wherein the blood inlet, the blood outlet, the gas inlet, and the gas outlet are arranged at the housing, wherein the housing is the housing of a dialyzer, and wherein a first adapter is provided that has an inlet and at least two outlets, with the inlet being connected to the gas outlet of the housing.

Abstract: Disclosed are an oxygenator and an extracorporeal membrane oxygenation device. The oxygenator includes: a housing, an upper end cover of the housing being provided with a blood inlet, and a lower end cover of the housing being provided with a blood outlet; and an oxygenation chamber, arranged in the housing, where the axis of the blood inlet and the axis of the blood outlet coincide with the axis of the oxygenation chamber. The blood inlet and the blood outlet are arranged at the center of the upper and lower parts of the oxygenation chamber, after the blood entering the oxygenation chamber is uniformly diffused to the periphery, the blood uniformly flows to the blood outlet from top to bottom due to gravity. The extracorporeal membrane oxygenation device includes the described oxygenator.

Abstract: An operational unit for locating and neutralizing pathogen cells in blood includes a time use cassette which has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood selectively block the light to produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, an electric field is activated in the cassette chamber areas that include the identified pathogen cells. Sufficient electric field energy is applied to destroy the identified pathogen cells. A pump refills the cassette holding chambers, returns the neutralized-pathogen blood to the patient, and the process is repeated for a period of time.

Abstract: A shunting system includes a housing through which blood flow is regulated when passing therethrough, for example, from the arterial side to the venous side of the circulatory system. The housing is easily separable into housing components, the separability providing for access to inner components including a blood filter, which is easily removable from a connector disc, the blood filter and connector disc held in place in the housing when the housing components are coupled.

Abstract: A barrier for use in negative pressure wound therapy can include a base layer and surface structures. The barrier can be used to reduce or prevent tissue ingrowth. A method of using a negative pressure wound therapy system can include positioning a perforated barrier in a wound. After positioning the perforated barrier in the wound, positioning a pad in the wound on top of the perforated barrier, positioning a seal on top of the wound to at least partially seal the perforated barrier and the foam in the wound, and applying negative pressure wound therapy to the wound.

Abstract: An apparatus for treating a tissue site with negative pressure, the apparatus having a dressing, a dressing interface fluidly coupled to the dressing, and a conduit comprising a first end and a second end. The first end may be fluidly coupled to the dressing interface. The apparatus may also comprise a conduit chamber configured to retain at least a portion of the conduit and to allow the second end of the conduit to be extended from the dressing interface.

Abstract: Embodiments of secure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, the apparatus includes a pressure source, a user interface, and a locking mechanism. The locking mechanism can be in one of at least two states, the at least two states including a first state in which the locking mechanism physically prevents user adjustment of one or more operational parameters with the user interface and a second state in which the locking mechanism does not physically prevent user adjustment of the one or more operational parameters with the user interface. The locking mechanism can include an authentication key and a receiver configured to receive an authentication input, which may be compared to the authentication key. Providing a sufficiently matching authentication input can transition the locking mechanism from the first state to the second state, permitting adjustments to the one or more operational parameters.

Abstract: A pneumatic cross-connect proportional valve provides the capability to calibrate pressure and vacuum sensors in a surgical cassette associated with a surgical console. Calibration of non-invasive pressure and vacuum sensors in a cassette by utilizing a proportional cross-connect to pressurize the lines with set pressure or vacuum the lines with set vacuum and measure the response of respective sensors in the cassette. The use of proportional pressure may be used along with other clearing methods to clear material clogging the aspiration channel pathways and tubing of the surgical system. Utilize the cross-connect functionality to more rapidly pressurize the aspiration line upon detection or prediction of a post occlusion surge, thereby reducing the pressure difference between the surgical field, the eye chamber, and aspiration line which may prevent, for example, a surge of fluid out of the anterior chamber of the eye.

Abstract: A hand-operated flow regulator is adapted to be inserted between an elastomeric bulb pump and a tubing as a part of an enema flow path. The hand-operated flow regulator comprises a main flow body, and a tubular pump coupling end part having a free pump coupling end and defining a first flow section. The tubular pump coupling end part extends via an exterior regulator body part into a tubular tube coupling end part having a free tube coupling end and defining a second flow section. An interior regulator body part is situated rotatable and substantially coaxially inside the exterior regulator body part, and a pivotable grip is in operative communication with the interior regulator body part to open and close the enema flow path.

Abstract: The present invention discloses a drug injection module including: a cylinder which is formed long, has a storage space capable of storing a drug therein, has a discharge port for discharging the drug formed at a front end, and has an open rear end; a piston that is inserted into the storage space through the rear end of the cylinder and slides in a longitudinal direction to discharge the drug; and a slip-assisting unit that is at least partially formed to protrude or depress from an outer surface of the cylinder to form an uneven cross-sectional shape, and generates variations in pressure acting on the surface when coming into contact with a user's body, in which the slip-assisting unit prevents the pressure of the human body acting along the periphery from becoming uniform and facilitates a slip in a state in which the cylinder is inserted into the human body.

Abstract: A method for predicting blood glucose levels, in particular, for postprandial blood glucose level prediction, the method being computer-implemented and comprising: receiving a first medical data set of a patient covering a time range, the first medical data set comprising glucose data and further other medical data of the patient, extracting a second medical data set from the first medical data set, wherein the second medical data set is a subset of the first medical data set and wherein the extracting comprises at least one of: identifying duplicates in the first medical data set and removing identified duplicates, identifying data values that lie above a predefined maximum threshold data value or identifying data values that lie below a predefined minimum threshold data value and removing data associated with the identified data values, identifying data values that differ from predetermined expected data values by more than a predetermined amount and removing data associated with the identified data values,

Abstract: A medical system includes an input assembly for receiving one or more user inputs. The input assembly includes at least one slider assembly for providing an input signal. Processing logic receives the input signal from the input assembly and provides a first output signal and a second output signal. A display assembly is configured to receive, at least in part, the first output signal from the processing logic and render information viewable by the user. The second output signal is provided to one or more medical system components. The information rendered on the display assembly may be manipulatable by the user and at least a portion of the information rendered may be magnified.

Abstract: The exemplary embodiments provide thermal weld structures that help prevent tearing of the adhesive layer of an on-body medical device when subject to lateral forces. These thermal weld structures help reduce the tearing by providing sacrificial thermal weld structures that will absorb forces and then potentially fail to thereby diffuse some of the lateral forces. The sacrificial thermal weld structures may take different forms. For instance, the sacrificial thermal weld structures may be gradient thermal weld structures where the amount of material melted in the gradient thermal weld structures decreases as a gradient along a dimension of the structures, such as their length. In some alternative embodiments, the width of the gradient thermal weld structure may vary instead of the height, or in conjunction with the height. In other exemplary embodiments, the sacrificial thermal weld structures may be dot thermal weld structures.

Abstract: Drug delivery device (1) comprising a delivery unit (3) including a drug container (6) comprising a barrel portion (6a) and a plunger (12) slidably mounted within the barrel portion and sealing against an inner surface of the barrel portion (6a) for containing a liquid drug (78) within the drug container; an electronic control system (47) and a plunger sensing system (70) including an optical sensor (71) comprising a transmitter (71a) and a receiver (71b), the transmitter configured for transmitting an optical signal to a back end (73) of the plunger (12) and the receiver configured to receive the optical signal reflected off the plunger back end (73), the plunger sensing system connected to the electronic control system (47) configured to measure a time of flight of the optical signal from the transmitter to the receiver and to determine therefrom a position of the plunger within the cylinder portion of the drug container.

Abstract: A drug delivery device (1), comprising a delivery unit (3) including a drug container (6), a liquid flow system (7), a pumping system (8), and a casing (9) enclosing therein the drug container, the pumping system and at least a part of the liquid flow system, the drug container comprising a barrel portion (6a) and a plunger (12) slidably mounted within the barrel portion and sealing the drug (78) within the container at one end of the barrel portion, the liquid flow system (7) connected fluidically to the drug container during delivery of the liquid drug.

Abstract: Some embodiments are directed to a medical device for fluidly connecting to a medical spike, including a spike port configured to receive therein the medical spike and establish fluid communication between the medical spike and the medical device. The spike-locking mechanism can be configured to resist extraction of the medical spike from the spike port.

Abstract: A method of producing an elastically deformable functional part for a medical device, devices for such methods, and a medical device having such a functional part. The functional part has an openable slit arrangement that widens or opens upon elastic deformation of the functional part and closes again in the absence of the deformation.

Abstract: A system for occlusion detection, including a cartridge containing an infusate, a plunger driven by a drive mechanism configured to be advanced within the cartridge to expel infusate from the cartridge, a force sensor configured to sense an actual force exerted by the plunger, and a control unit configured to determine an estimated force based on an expected decay in frictional force between the plunger and the cartridge for comparison to the actual force sensed by the force sensor, wherein a deviation between the estimated force and the actual force exceeding a threshold triggers an occlusion alarm.

Abstract: Systems, devices and methods are provided for incorporating a medication delivery device into an integrated management system. The integrated management system may be an integrated diabetes management system and may include a glucose monitor, a connected insulin pen, and software. The integrated management system may produce a plurality of reports that may include data related to analyte levels (e.g., glucose levels) and medication delivered (e.g., insulin delivered). The medication delivery device may also provide feedback to the user.

Abstract: Described herein are systems and methods for sensing an analyte concentration and delivering a composition to a subcutaneous space of a subject comprising a sensing cannula, which comprises an electrode for detecting the analyte concentration in the subcutaneous space.

Abstract: Method and system for providing an integrated analyte monitoring system and on-body patch pump with multiple cannulas and a sensor combination is provided.

Abstract: A transport lock assembly included in a sub-assembly for a medicament delivery device is disclosed that includes a powerpack having a locking member configured to interact with a control member, where the locking member is movable relative to the control member and a body of the power pack from a locked state in which the control member is immobilized, to an unlocked state in which the control member is free to move. The locking member can be moved from the locked to the unlock state by interaction with a needle guar or with an inner surface feature of housing into which the sub-assembly is inserted during the final assembly of the medicament delivery device.

Abstract: An injection device includes an injector body. The injection device also includes a cartridge coupled to the injector body and having a first height and comprising an orifice. The injector device also includes a cap coupled to the injector body having a second height and including an outer rim, wherein the outer rim surrounds the cartridge, and wherein the first height is greater than the second height.

Abstract: A drug delivery system comprising: a plurality of needles; a needle guide for guiding and holding the plurality of needles during insertion into a patient's spine; a syringe containing a drug which is to be delivered into the patient's spine; a port multiplier comprising an inlet port connectable to the syringe and a plurality of outlet ports; and a plurality of tubes for providing fluid connections between the outlet ports of the port multiplier and the plurality of needles.

Abstract: According to the present disclosure, by a simple operation of pressing the press-fitting block with the pressing part, a press-fitting force of the press-fitting block is automatically released at a predetermined time after the needle part penetrates a skin layer, due to the release of the press-fitting force of the press-fitting block, a practitioner can easily determine a. time to detach and separate the needle part, due to guiding of the time to detach and separate the needle part, even an unskilled person can easily use the microneedle, by a uniform amount of drug being injected into patients, the same therapeutic effect can be given to the patients, and in particular, by the needle part being promptly removed after the drug of the needle part is injected into the skin layer, there is no concern about the needle part staying in the skin layer for an excessive amount of time.

Abstract: An auto-injector includes a front housing carrying a syringe and an activation cap covering a needle of the syringe, and a rear housing including a drive assembly for automatically deliver agent(s) from the syringe when the device is activated. The rear housing includes a gas canister and an opener mechanism for opening the canister into a set of chambers of an inner housing within the outer housing. When a contact surface of the activation cap is pressed against a subject's skin to insert the needle, the activation cap retracts into the outer housing and activates the opener mechanism to release pressurized gas from the canister into the chambers to advance a plunger within the inner housing to deliver the agent(s) from the syringe into the subject. After the injection is completed and the device is withdrawn away from the skin, the activation cap automatically advances to cover the needle.

Abstract: An injection system includes an injector device and a base station. The injector device includes a cartridge. The injector device additionally includes an injector body coupled to the cartridge at a first end of the injector body, the injector body including a plug at a second end of the injector body. The injector device further includes a spring coupled to the cartridge. The base station is configured to electrically couple to the plug, wherein the base station comprises a motor. Rotation of the motor transmits power to the injector device compressing the spring and drawing medicine from a vial into the cartridge.

Abstract: An injection system includes an injector device and a base station. The injector device includes a cartridge. The injector device further includes an injector body coupled to the cartridge at a first end of the injector body, the injector body comprising a plug at a second end of the injector body. The base station is configured to couple to the plug, wherein the base station comprises a motor, and wherein rotation of the motor draws medicine from a vial into the cartridge, and wherein a volume of the medicine drawn from the vial into the cartridge is in excess of an set dosage.

Abstract: Syringe tip caps are described herein. Such syringe tip caps may include a cup, a cap, a locking feature, a peelable seal and an absorbent material. The cap having locking features and a chamber appropriately sized to adapt to and interlock with an annular wall of the cup.

Abstract: A cylindrical member is used for sucking a fluid into an inside of the cylindrical member and/or discharging a fluid to an outside of the cylindrical member by allowing a plunger to move inside the cylindrical member, the cylindrical member including: a first cylindrical tube inside which the plunger is to slide; and a second cylindrical tube being continuous with the first cylindrical tube and having an inner diameter larger than an inner diameter of the first cylindrical tube, the second cylindrical tube being configured to store a lubricant.

Abstract: A syringe including a syringe body extending from a proximal end to a distal end, and a stabilizing element provided on the distal end of the syringe body, a portion of the stabilizing element extending substantially perpendicular to a longitudinal axis of the syringe body. A multi-use disposable set (MUDS) includes a plurality of syringes, each syringe having a syringe body, a proximal end, a distal end spaced apart from the proximal end along a longitudinal axis of the syringe body, a stabilizing element provided on the distal end, a portion of the stabilizing element extending substantially perpendicular to the longitudinal axis of the syringe body, and a manifold in fluid communication with the distal end of each of the plurality of syringes.

Abstract: Aspects of the present invention relate to an injection device comprising a cartridge arranged to contain a medicament and piston and a drive mechanism arranged to move the piston from a first position where medicament is contained within the syringe and a second position in which the medicament has been delivered from the cartridge to a user. The drive mechanism includes a flexible portion which co-operates with another part of the injection device such that the flexible portion is moved towards the central axis of the injection device during a portion of the movement of the drive mechanism from the first position to the second position and disengages from the another part of the injection device at or near the second position to indicate that the medicament has been delivered from the cartridge.

Abstract: A drug delivery device includes a housing element, a release member, a plunger rod, a transfer member arranged rotatably with respect to the housing element, an energy member, a displaceable element being displaceable between a first position and a second position, wherein the transfer member and the plunger rod are operatively coupled such that a rotation of the transfer member is converted into an axial movement of the plunger rod, the drug delivery device has a first locked state, wherein, in the first locked state, (i) a releasable first locking mechanism prevents a rotational movement of the transfer member, (ii) the release member is in an initial position and arranged to hold the displaceable element in the first position, and (iii) the transfer member is coupled to the displaceable element held in the first position via an axial-lock interface which prevents an axial movement of the transfer member.

Abstract: Injection endpoint signalling device for mounting on a pre-filled syringe comprising a needle shroud in which the shroud translates from a first, retracted position, to a second, extended position. The injection endpoint signalling device comprises a near field communications (NFC) circuit and an activation switch, and when mounted on the pre-filled syringe, in the first, shroud-retracted position, the activation switch maintains the NFC circuit in an inactive state in which an injection endpoint information is inaccessible to the NFC circuit, and in the second, shroud-extended position, the activation switch maintains the NFC circuit in an active state in which the injection endpoint information is accessible to the NFC circuit. The activation switch is moved from the inactive state to the active state via mutually cooperating surface engagement between a part of the shroud and the activation switch.

Abstract: A drug delivery device includes a housing element, a release member, a plunger rod, an energy member, and a displaceable element. The drug delivery device has a first locked state in which the release member is in a distal position and arranged to hold the displaceable element in a first radial position to prevent a movement of the plunger rod in distal direction by the energy member. The drug delivery device is configured to be switched from the first locked state into a released state by moving the release member from the distal position into a proximal position. In the released state, the release member no longer holds the displaceable element in the first radial position, which enables a movement of the displaceable element from the first radial position into a second radial position to release the plunger rod such that the plunger rod moves in the distal direction.

Abstract: An apparatus for the destruction of needles and other sharp objects using electrical current. In addition to an incineration port where needles are inserted for destruction, the apparatus also includes certain improvements related to the shape and composition of the electrical contacts, certain safety circuits related to power source overheating, and digital monitoring and control of current throughput to minimize sparking.

Abstract: A needle assembly configured to be part of a drug delivery device comprises a plurality of extendable and retractable needles. The needles are fluidly coupled when extended, and fluidly decoupled when retracted. When the needles are extended, a first needle pierces a patient's skin, and a second needle pierces a septum of a drug cartridge to deliver a medication. Once the medication has been delivered, the needles may then retract within a needle assembly housing. The needle assembly may also be part of a partially disposable drug delivery device and may be used with multiple different drug cartridges. Multiple embodiments of the needle assembly are disclosed.

Abstract: A needle assembly configured to be part of a drug delivery device comprises a plurality of extendable and retractable needles. The needles are fluidly coupled by a flexible connector, which is configured to maintain fluid connection between the needles throughout their movement. When the needles are extended, a first needle pierces a patient's skin, and a second needle pierces a septum of a drug container to deliver a medication. Once the medication has been delivered, the needles may then retract within a needle assembly housing. The needle assembly may also be part of a partially disposable drug delivery device and may be used with multiple different drug cartridges. Multiple embodiments of the needle assembly are disclosed.

Abstract: Bubble traps for use in medical fluid lines and medical fluid bubble trap systems are disclosed herein. In some embodiments, the bubble trap is configured to trap gas (e.g., air) that flows into the bubble trap from a fluid line. In some embodiments, the bubble trap includes an inlet and an outlet and a chamber between the inlet and the outlet. For example, in some embodiments, the bubble trap is configured to inhibit gas from flowing into the outlet once gas flows into the chamber from the inlet. In some embodiments, the bubble trap is in fluid communication with a source container, a destination container, and/or a patient.