Patents Issued in February 1, 2024
  • Publication number: 20240033498
    Abstract: A check valve includes an upper housing defining an inlet of the check valve, a lower housing defining an outlet of the check valve, and a cavity interposed between and defined by the upper and lower housings for fluidly connecting the inlet and the outlet. The check valve further includes a valve member mounted in the cavity to selectively permit fluid flow in a first direction, and prevent fluid backflow in a second direction opposite to the first direction. The valve member includes a valve body and a valve stem portion extending axially through a central axis of the valve body. The valve member may further include a plurality of feet disposed about and extending longitudinally from an outer circumferential perimeter of the valve body.
    Type: Application
    Filed: October 13, 2023
    Publication date: February 1, 2024
    Inventors: Raymond P. FEITH, Eugene MASON, Christian CREW
  • Publication number: 20240033499
    Abstract: A cannula for an ECLS system may include a tubular member and an actuatable structure. The actuatable structure may be responsive to an external stimulus such that an inner diameter of the tubular member changes as the external stimulus changes. A system may include the cannula and a controller in electrical communication with the actuatable structure. The controller may be user-configurable to set a desired value for an inner diameter of the tubular member. A method of connecting a patient's vasculature to an ECLS system may include advancing a delivery sheath into the vasculature, moving the delivery sheath relative to the cannula to expose the cannula within the vasculature, and shifting the actuatable structure from a first configuration to a second configuration while at least a portion of the cannula is disposed within the vasculature to change an inner diameter of the tubular member.
    Type: Application
    Filed: July 28, 2022
    Publication date: February 1, 2024
    Applicant: CardiacAssist, Inc.
    Inventors: Michael J. Linehan, Robert G. Svitek
  • Publication number: 20240033500
    Abstract: An evaluating method for a useful lifespan of a conductive gel is applied to a non-implantable electrical stimulation device. The non-implantable electrical stimulation device includes an electrical stimulator and an electrode assembly. The electrical stimulator is detachably electrically connected to the electrode assembly. The evaluating method for the useful lifespan of the conductive gel includes the following steps. A first measuring signal is generated, and the first measuring signal flows through a conductive area to generate a first signal to be tested. The first signal to be tested is received. The first total impedance value is obtained according to the first signal to be tested. The impedance value of the conductive gel is obtained according to the first total impedance value, so as to evaluate the useful lifespan of the conductive gel.
    Type: Application
    Filed: December 29, 2022
    Publication date: February 1, 2024
    Applicant: GIMER MEDICAL. Co. LTD.
    Inventors: Wei-Chih HUANG, Jian-Hao PAN, Wan Ting CHIANG, Chia-Chi WANG
  • Publication number: 20240033501
    Abstract: The present invention provides a compression garment for transcutaneous or neuromuscular electrical stimulation. The garment is adapted to be in contact with a part of the body. The garment is made from an elastic stretchable material. The garment comprises at least one compression band having a first portion and a second portion. The second portion is adapted to be coupled with an electrode, a portion of an electrode or a plurality of electrodes for contacting skin in use. The second portion has lower elasticity compared to that of the garment material of the first portion or no elasticity. Modulus of elasticity of the garment material in elongation direction and/or resting length of the garment material in the elongation direction in the first portion are selected so that pressure exerted by the second portion on a wearer when the garment is in use is equal or greater than a minimum predetermined pressure.
    Type: Application
    Filed: August 9, 2021
    Publication date: February 1, 2024
    Applicant: BIO-MEDICAL RESEARCH LIMITED
    Inventors: Conor MINOGUE, Chandra LAKSHMANAN, Maggie MCBRIDE, Fiona O'Sullivan
  • Publication number: 20240033502
    Abstract: Disclosed are materials/systems and methods that are selective for the formation of hydrogen peroxide (H2O2) via an electrochemical reaction. The materials/systems comprise a substrate and at least one pair of electrodes positioned on or within the substrate, wherein each pair of electrodes comprises an anode and a cathode. At least one of the anode and the cathode comprise a catalyst that can form hydrogen peroxide (H2O2). The catalyst can comprise a nanoporous Cu catalyst.
    Type: Application
    Filed: July 26, 2022
    Publication date: February 1, 2024
    Inventors: Anne Co, Wesley Thio
  • Publication number: 20240033503
    Abstract: An implant provided with an auto-generator generating an electric charge. One or more nanogenerators are incorporated into or onto the implant or used as stand-alone devices. It is believed that electric charge improves the healing of damaged/injured tissues.
    Type: Application
    Filed: July 27, 2022
    Publication date: February 1, 2024
    Inventors: Todd Shanks, George Alexander Jones
  • Publication number: 20240033504
    Abstract: Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. An implantable baroreflex activation system includes a control system having an implantable housing, an electrical lead, attachable to the control system, and an electrode structure. The electrode structure is near one end of the electrical lead, and includes a monopolar electrode, a backing material having an effective surface area larger than the electrode, and a releasable pivotable interface to mate with an implant tool. The electrode is configured for implantation on an outer surface of a blood vessel and the control system is programmed to deliver a baroreflex therapy via the monopolar electrode to a baroreceptor within a wall of the blood vessel.
    Type: Application
    Filed: October 12, 2023
    Publication date: February 1, 2024
    Inventors: Adam CATES, Eric LOVETT, Loren MURNEY, Kip LUDWIG, Paul PIGNATO, Brian SOLTIS
  • Publication number: 20240033505
    Abstract: A method for treating pain or discomfort in a patient is disclosed. The method comprises stimulating a cranial nerve with an electrical signal. The pain or discomfort may be a withdrawal symptom. The cranial nerve may be in an auricular area of the patient. The cranial nerve may be cranial nerve V, cranial nerve VII, cranial nerve IX, cranial nerve X, or branches of greater and lesser occipital nerves thereof and their associated neurovascular bundles. The withdrawal symptom may result from cessation of an opioid. The method may further comprise administering a secondary drug treats one or more of the withdrawal symptoms and addiction. The secondary drug may be administered about one day to about one week after initiating the stimulating step.
    Type: Application
    Filed: October 9, 2023
    Publication date: February 1, 2024
    Inventors: Christopher R. Brown, Gary M. PETERSON
  • Publication number: 20240033506
    Abstract: An apparatus configured to receive and manipulate a cochlear implant type electrode array, where at least the front portion of the electrode, includes an outer, detachable casing or tube, where the casing is attached along the circumference of main axis of an electrode array. Predetermined portions of outer removable casing are slid off and/or removed from the electrode array by the apparatus, during electrode array insertion surgery. The removable casing, temporarily encasing the electrode array, provides a variety of functions, including, imparting additional rigidity to thin, flexible type electrode arrays, straightening pre-curved electrodes, and the like. The linear structure, provided by certain embodiments, combined with the additional rigidity, provides a surgeon additional control of an electrode array during cochlea implantation surgery.
    Type: Application
    Filed: July 25, 2023
    Publication date: February 1, 2024
    Inventors: Michael Joseph Piatt, Charles David Rike
  • Publication number: 20240033507
    Abstract: An apparatus includes a first portion configured to be implanted at a first location on or within a recipient's body and a second portion configured to be implanted on or within the recipient's body and configured to be mechanically coupled to a transducer and/or reservoir. The second portion includes an orifice and an elongate element extending through the orifice. The elongate element is configured to be in mechanical communication with a second location on or within the recipient's body, the second location spaced from the first portion. The first portion and the second portion are configured to be implanted with the elongate element in mechanical communication with the second location prior to the second portion being operatively coupled to the transducer and/or the reservoir.
    Type: Application
    Filed: December 27, 2021
    Publication date: February 1, 2024
    Inventors: Wim Bervoets, Olivier Le Caharec
  • Publication number: 20240033508
    Abstract: A load bearing implant provided with an auto-generator generating an electric charge. One or more nanogenerators are incorporated into or onto the load bearing implant or a delivery vehicle. It is believed that electric charge improves the healing of damaged/injured tissues.
    Type: Application
    Filed: July 27, 2022
    Publication date: February 1, 2024
    Inventors: Todd Shanks, George Alexander Jones
  • Publication number: 20240033509
    Abstract: A bone stimulating method and device for treating injured or diseased bone tissue, includes exposing the injured or diseased bone tissue to a first electric field over a predetermined treatment period, the first electric field ranging from 10 mV/cm to 40 mV/cm and having a first predetermined time period within the predetermined treatment period and exposing the injured or diseased bone tissue to a second electric field over the predetermined treatment period, the second electric field ranging from 10 mV/cm to 60 mV/cm and having a second predetermined time period within the predetermined treatment period that is greater than the first predetermined time period.
    Type: Application
    Filed: August 1, 2022
    Publication date: February 1, 2024
    Inventor: Carl T. BRIGHTON
  • Publication number: 20240033510
    Abstract: A bone stimulating method and device for treating injured or diseased bone tissue, includes exposing the injured or diseased bone tissue to a first electric field over a predetermined treatment period, the first electric field ranging from 10 mV/cm to 40 mV/cm and having a first predetermined time period within the predetermined treatment period and exposing the injured or diseased bone tissue to a second electric field over the predetermined treatment period, the second electric field ranging from 10 mV/cm to 60 mV/cm and having a second predetermined time period within the predetermined treatment period that is greater than the first predetermined time period.
    Type: Application
    Filed: September 19, 2023
    Publication date: February 1, 2024
    Inventor: Carl T. BRIGHTON
  • Publication number: 20240033511
    Abstract: An apparatus includes a frame, a sensor, and an electric stimulator. The frame is removably couplable to a portion of a limb. The sensor is configured to produce a first signal associated with a gait characteristic at a first time, and a second signal associated with the gait characteristic at a second time, after the first time. The electric stimulator is removably coupled to the frame and is in electrical communication with an electrode assembly and the sensor to receive the first signal substantially at the first time and the second signal substantially at the second time. Based in part on the gait characteristic at the first time, the electric stimulator sends a third signal to the electrode assembly to provide an electric stimulation to a portion of a neuromuscular system of the limb substantially during a time period defined between the first time and the second time.
    Type: Application
    Filed: May 3, 2023
    Publication date: February 1, 2024
    Applicant: Bioness Inc.
    Inventors: Arkady GLUKHOVSKY, Keith MCBRIDE
  • Publication number: 20240033512
    Abstract: An external neurostimulator includes a housing including a base housing and a top housing, a power source, a pulse generator, and a first and second series of spring-loaded pins electrically coupled to the pulse generator. The top housing includes a central portion, a first side door hingedly coupled to a first side of the central portion, and a second side door hingedly coupled to a second side of the central portion. Each of the first side door and the second side door include a channel formed thereon that is configured to directly receive a proximal end portion of an implantable lead. Each channel includes a series of longitudinally spaced-apart openings formed on the first side door and the second side door, respectively. The first and second series of spring-loaded pins extend through the series of longitudinally spaced-apart openings of the channel on the first and second side doors, respectively.
    Type: Application
    Filed: March 25, 2022
    Publication date: February 1, 2024
    Inventors: Apratim DIXIT, Ivan TZVETANOV, Cameron KARAMIAN, Ivan Wei Tai LIN
  • Publication number: 20240033513
    Abstract: An apparatus comprising: at least one processor; and at least one memory including computer program code, the at least one memory and computer program code configured to, with the at least one processor, cause the apparatus to: receive a sensor output from a mechanomyography sensor configured to monitor muscle activity of a muscle in a human or animal body; and control, in response to the received sensor output, an electrical stimulus applied by a muscle stimulator to the muscle to modify said muscle activity, wherein the electrical stimulus is applied with an amplitude below the motor threshold of the muscle simultaneously during monitoring of the muscle activity by the mechanomyography sensor.
    Type: Application
    Filed: December 16, 2020
    Publication date: February 1, 2024
    Inventors: Ravi Vaidyanathan, Samuel Wilson, Dario Farina, Thomas Watts
  • Publication number: 20240033514
    Abstract: One aspect of the present disclosure is a system including a waveform generator, a controller, and an electrical contact. The waveform generator is for generating an electrical nerve conduction block (ENCB). The controller is coupled with the waveform generator. The controller is configured to receive an input comprising at least one parameter to adjust the ENCB. The electrical contact is coupled with the waveform generator. The electrical contact is configured to be placed into contact with a nerve. The electrical contact comprises a high charge capacity material that prevents formation of damaging electro-chemical products at a charge delivered by the ENCB. The electrical contact is configured to deliver the ENCB to the nerve to block transmission of a signal related to a pain through the nerve.
    Type: Application
    Filed: October 9, 2023
    Publication date: February 1, 2024
    Inventors: Niloy Bhadra, Narendra Bhadra, Kevin L. Kilgore, Scott Lempka, Jesse Wainright, Tina Vrabec, Manfred Franke
  • Publication number: 20240033515
    Abstract: Provided is a device for relieving headache and pain caused by temporomandibular joint disorders may include: a body having a neck band surroundingly worn on a user's neck, first connectors extending forwardly from both ends of the neck band by first set lengths, and second connectors extending upwardly from front ends of the first connectors by second set lengths; first low frequency electrostimulators disposed on the second connectors and coming into close contact with the temporalis muscles, when the body is worn on the user's head, to apply low frequencies to the temporalis muscles; and second low frequency electrostimulators disposed on the connected portions between the first connectors and the second connectors and coming into close contact with the masseter muscles, when the body is worn on the user's head, to apply low frequencies to the masseter muscles.
    Type: Application
    Filed: August 31, 2023
    Publication date: February 1, 2024
    Inventors: Tae Hun KIM, Won Sik BAE, Jae Hyeong OH, Dong Jin YOU
  • Publication number: 20240033516
    Abstract: Methods and apparatuses for treating a patient having a brain lesion (e.g., a stroke patient) by applying a charge-balanced, low-frequency alternating current stimulation (ACS) to a region of the patient's brain immediately before and/or during a directed movement. The charge-balanced, low-frequency ACS may have a depolarizing phase that is slower than the hyperpolarizing phase (e.g., the depolarizing phase may have a frequency of 15 Hz or less and the hyperpolarizing phase with a frequency greater than 15 Hz). The ACS stimulation field may be greater than 1.5 V/m. The ACS may be applied during a preferred excitation phase.
    Type: Application
    Filed: February 9, 2022
    Publication date: February 1, 2024
    Inventors: Karunesh GANGULY, Preeya KHANNA, Kyungsoo KIM
  • Publication number: 20240033517
    Abstract: A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.
    Type: Application
    Filed: August 9, 2023
    Publication date: February 1, 2024
    Inventors: Howard Levin, Mark Gelfand
  • Publication number: 20240033518
    Abstract: One aspect of the present disclosure relates to a system that can prevent unintended signal components (noise) in an electric waveform that can be used for at least one of neural stimulation, block, and/or sensing. The system can include a signal generator to generate a waveform that includes an intended electric waveform and unintended noise. The system can also include a signal transformer device (e.g., a very long wire) comprising a first coil and a second coil. The first coil can be coupled to the signal generator to receive the waveform and remove the unintended noise from the electric waveform. The second coil can pass the electric waveform to an electrode. The second coil can be coupled to a capacitor that can prevent the waveform from developing noise at an electrode/electrolyte interface between an electrode and a nerve.
    Type: Application
    Filed: October 11, 2023
    Publication date: February 1, 2024
    Inventor: Manfred Franke
  • Publication number: 20240033519
    Abstract: Devices, systems, and techniques are described for selecting an evoked compound action potential (ECAP) growth curve based on a posture of a patient. The ECAP growth curve defines a relationship between a parameter defining delivery of stimulation pulses delivered to the patient and a parameter of an ECAP signal of a nerve of a patient elicited by a stimulation pulse. In one example, a medical device detects a posture of a patient and selects an ECAP growth curve corresponding to the detected posture. The medical device selects, based on the ECAP growth curve corresponding to the detected posture and a characteristic of a detected ECAP signal, a value for a parameter for defining delivery of the stimulation pulses to the patient and controls delivery of the stimulation pulses according to the selected value for the parameter.
    Type: Application
    Filed: October 6, 2023
    Publication date: February 1, 2024
    Inventors: David A. Dinsmoor, Christopher L. Pulliam, Hank T. Bink, Kristin N. Hageman
  • Publication number: 20240033520
    Abstract: Medical devices that provide stimulation therapy that is adjusted based on sensed physiological signals compensate for drifting of those physiological signal values that can lead to stimulation control reaching limits and becoming less effective. The medical devices determine average values of the physiological signals and use those average values to compute adjusted physiological signal threshold(s). The adjusted threshold(s) bring the physiological signals closer to or within the threshold(s) to allow the stimulation adjustments to be made within stimulation limits that can influence the physiological signal to continue to be within the threshold(s) and provide more effective therapy.
    Type: Application
    Filed: July 24, 2023
    Publication date: February 1, 2024
    Inventor: Martinus Adrianus Godefridus Maria Bakx
  • Publication number: 20240033521
    Abstract: A nerve stimulation system includes an electrode, an electrode controlling device coupled to the electrode and configured to control the electrode to electrically stimulate a peripheral nerve according to a nerve stimulation signal, and a signal generating device coupled to the electrode controlling device and configured to generate the nerve stimulation signal. The nerve stimulation signal is a signal with a square envelope. The square envelope periodically includes an on-time period with a pulse amplitude and an off-time period without the pulse amplitude, and a ratio of the on-time period and the off-time period is not less than 1, and a length of the off-time period is not longer than 5 seconds.
    Type: Application
    Filed: July 28, 2023
    Publication date: February 1, 2024
    Inventors: Yuan-Yu Hsueh, Wentai Liu, Szu Han Chen, Wan-Ling Tseng, CHUN-WEI LIN
  • Publication number: 20240033522
    Abstract: Recording evoked neural responses comprises delivering a stimulus from one or more stimulus electrodes to a neural pathway in order to give rise to an evoked compound action potential (ECAP) on the neural pathway. And, recording with measurement circuitry, during delivery of at least part of the stimulus, a neural compound action potential signal sensed at one or more sense electrodes. And, processing the recording of the neural compound action potential signal to determine at least one characteristic of the ECAP. At least one characteristic of the stimulus is then defined based on the determined at least one characteristic of the ECAP.
    Type: Application
    Filed: February 9, 2022
    Publication date: February 1, 2024
    Applicant: Saluda Medical Pty Ltd
    Inventors: Dean Michael Karantonis, Peter Scott Vallack Single, James Hamilton Wah
  • Publication number: 20240033523
    Abstract: Provided is an implantable pulse generator (IPG) for providing electrical pulses to a patient during neurostimulation therapy. The IPG includes a controller for controlling operations of the IPG, a battery for powering the IPG, a therapeutic stimulation circuitry for generating electrical pulses to stimulate neural tissue of the patient, and internal diagnostic circuitry for digitizing device signals to control operations of the IPG. The internal diagnostic circuitry includes a multi-stage comparator including a pre-amplifier configured to receive an analog input signal and convert the analog input signal into a first analog output signal and second analog output signal. The multi-stage comparator also including a first latch circuit with a first receiving device that receives the first analog output signal, a second receiving device that receives the second analog output signal, and configured to convert the first analog output signal and second analog output signal into a digital output signal.
    Type: Application
    Filed: June 27, 2023
    Publication date: February 1, 2024
    Inventor: Daran DeShazo
  • Publication number: 20240033524
    Abstract: A stimulation system configured to be implanted in a patient includes an implantable pulse generator (IPG) and an implantable lead system. The IPG includes a processor, a memory device, a power supply, and an inertial sensing unit configured to measure one or more physiological indicators of the patient. The implantable lead system includes at least one electrical lead coupled to the power supply and at least one electrode at a distal end of the electrical lead. The memory device includes instructions that cause the IPG to receive the physiological indicators within an initial range; increase the initial range to an enlarged range in response to the physiological indicators crossing a threshold maximum value or a threshold minimum value of the initial range; receive the physiological signals within the enlarged range, analyze the physiological indicators, and deliver stimulation to the patient through the electrode in response to the physiological indicators.
    Type: Application
    Filed: July 25, 2023
    Publication date: February 1, 2024
    Inventors: Brian Shelton, Brian Mech, Sahar Elyahoodayan
  • Publication number: 20240033525
    Abstract: Methods and systems for spinal cord stimulation (SCS) are disclosed. The methods and systems involve using electrode leads implanted within the patient's spinal column to record neural responses evoked by the stimulation. The disclosed neural responses are different in several respects from electrical responses that have previously been measured in the context of SCS, such as stimulation artifacts and evoked compound action potentials (ECAPs). The disclosed neural responses typically occur later in time following the evoking stimulation pulse. Another distinguishing feature is that disclosed neural responses are generally most prominently observed with consistent, relatively unchanging amplitudes when the evoking stimulation frequency is ultra-low, for example, about 10 Hz or less.
    Type: Application
    Filed: July 26, 2023
    Publication date: February 1, 2024
    Inventors: Tianhe Zhang, Rosana Esteller, Marom Bikson
  • Publication number: 20240033526
    Abstract: Methods and systems are described for detecting if a stimulation lead implanted in a patient's brain has moved. Lead movement occurring between a first time and a second time may be determined by comparing features extracted from evoked potentials recorded at the two times. The disclosed methods and systems are particularly useful for determining if a stimulation lead has moved between the time it was implanted in the patient's brain and the time that stimulation parameters are being optimized. Lead movement during implantation, during parameter optimization, and during or between other lead optimization processes may be determined as well.
    Type: Application
    Filed: October 9, 2023
    Publication date: February 1, 2024
    Inventors: Rosana Esteller, Mahsa Malekmohammadi, Andrew Haddock, Tianhe Zhang
  • Publication number: 20240033527
    Abstract: An example method includes obtaining, by processing circuitry, at least one first electrical stimulation parameter of an electrical stimulation program that defines an electrical stimulation therapy deliverable to a patient and determining an electrical characteristic of a stimulation system configured to deliver the electrical stimulation therapy according to the electrical stimulation program. The method further includes determining, based on the electrical characteristic and the at least one first electrical stimulation parameter, a maximum selectable value for a second electrical stimulation parameter of the electrical stimulation program and outputting, for display by a user interface, the maximum selectable value.
    Type: Application
    Filed: July 28, 2023
    Publication date: February 1, 2024
    Inventor: Andrew L. Schmeling
  • Publication number: 20240033528
    Abstract: System and methods for providing a pulsed therapy comprises an implantable pulse generator (IPG) having circuitry configured to control generation and delivery of electrical pulses using at least one electrode of a stimulation lead. The IPG further comprises memory configured to store program instructions and one or more processors configured to execute the program instructions. The one or more processors are configured to deliver the pulses, having a corresponding pulse duration and an amplitude, to the at least one electrode. The amplitude can vary over the pulse duration of at least one of the pulses. The processor(s), monitor a signal indicative of a present level of the amplitude of the at least one pulse, and based on the signal, declare a pulse valid based on the present level satisfying an initial criteria for at a sub-duration of the pulse duration that is less than an entire pulse duration.
    Type: Application
    Filed: July 11, 2023
    Publication date: February 1, 2024
    Inventors: Daran DeShazo, Christopher Palmer
  • Publication number: 20240033529
    Abstract: Provided is an implantable pulse generator (IPG) that includes a controller, and stimulation circuitry for generating electrical pulses to stimulate neural tissue of the patient. The IPG also includes a static random-access memory (SRAM) component for storing data to control the generating of the electrical pulses, wherein the SRAM component is connected to at least the controller through a first interface bus at a first word width and is connected to at least the stimulation circuitry through a second interface bus at a second word width. The SRAM component comprises column select logic that decodes read or write (R/W) access from the controller and provides for selective connection of each column of the SRAM component to the first interface bus during the R/W access, or to the second interface bus during stimulation operations to provide stimulation control data to components of the stimulation circuitry.
    Type: Application
    Filed: June 27, 2023
    Publication date: February 1, 2024
    Inventor: Daran DeShazo
  • Publication number: 20240033530
    Abstract: In accordance with the present invention, various embodiments of neurostimulators and stimulation systems are disclosed that provide different shapes and patterns of stimulus pulses and trains of pulses with fixed and no fixed frequencies. The neurostimulator can be configured to provide high frequency stimulation and also be implantable in the head or neck regions in order to stimulate nerves and nerve ganglions in the head and neck regions and also stimulate the brain.
    Type: Application
    Filed: October 4, 2023
    Publication date: February 1, 2024
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Brian R. Dearden, Harshit Suri, Edward K. F. Lee
  • Publication number: 20240033531
    Abstract: Disclosed are methods to treat patients with AFib by monitoring their heart rhythm to determine the presence and/or the number of episodes of long duration AFib, and optionally the extent of AFib burden. Patients who meet threshold requirements are qualified for the treatment of AFib with a dosage of budiodarone. Patient monitoring is continued in order confirm that the patient is and remains responsive to budiodarone therapy including dose adjusting the patient to achieve such therapy. Subsequently, monitoring is continued to confirm that the patient remains responsive. These methods allow for treatment of the AFib and, correspondingly, reduce or delay the risk of stroke and/or congestive heart failure in the treated patient.
    Type: Application
    Filed: October 4, 2023
    Publication date: February 1, 2024
    Inventors: Pascal Druzgala, Peter Gerard Milner
  • Publication number: 20240033532
    Abstract: Electrical component for an implantable medical device comprises an outer shell forming first and second side faces, a functional element enclosed in the outer shell, and an arrangement of connection devices arranged on the outer shell for establishing an electrical connection of the functional element to a component of the implantable medical device outside of the outer shell. A first connection device is arranged on the first side face and a second connection device is arranged on the second side face, wherein the electrical component is configurable to assume different configuration states, wherein in a first configuration state the first connection device is configured to establish said electrical connection and the second connection device is deactivated, and in a second configuration state the first connection device is deactivated and the second connection device is configured to establish said electrical connection.
    Type: Application
    Filed: November 24, 2021
    Publication date: February 1, 2024
    Applicant: BIOTRONIK SE & Co. KG
    Inventors: Ingo WEISS, Thomas DÖRR
  • Publication number: 20240033533
    Abstract: An embodiment includes: (1) determining a first orientation of first and second portions of a first image with respect to one another, wherein the first portion depicts a first metallic implant and the second portion depicts a first coil, wherein the first orientation is based on: (a) a first distance between the first and second portions with respect to one another, and (b) a first direction between the first and second portions with respect to one another; (2) select a first target orientation for the first metallic implant and the first coil with respect to one another from a library of target orientations between implants and coils; (3) determine a first difference between the first orientation and the first target orientation; and (4) output first reorientation instructions via the at least one I/O port in response to determining the first difference between the first orientation and the first target orientation.
    Type: Application
    Filed: December 20, 2021
    Publication date: February 1, 2024
    Inventors: David Greenberg, John Tepper, Rajiv Chopra
  • Publication number: 20240033534
    Abstract: Systems and methods for treatment of a mental disorder of a subject are disclosed. The methods include receiving a first set of electroencephalography (“EEG”) measurements that each correspond to brain activity at one or more of a plurality of zones of a brain of the subject. The methods further include determining a target frequency for the subject based on the first set of EEG measurement where, the target frequency being an EEG frequency where the brain of the subject operates optimally across a plurality of EEG channels in an alpha brainwave, and generating a treatment protocol for the subject based on the target frequency. The treatment protocol includes one or more individualized transcranial magnetic stimulation (TMS) treatments that each include application a plurality of magnetic stimulation pulses for a defined time period and at a frequency of about the target frequency.
    Type: Application
    Filed: October 16, 2023
    Publication date: February 1, 2024
    Inventor: Shannon Lea Malish
  • Publication number: 20240033535
    Abstract: Provided is phototherapy progress measuring method for measuring a progress of a phototherapy of an affected portion by employing a fluorescent agent. The method includes: detecting a first fluorescence intensity, which is an intensity of fluorescence generated in the affected portion as a result of radiating therapeutic light beam onto the affected portion; and calculating, by employing the first fluorescence intensity and reference data, progress information representing the progress of the phototherapy of the affected portion. The reference data are determined on the basis of a fluorescence intensity associated with the fluorescent agent that is in the affected portion and that is not involved in the phototherapy.
    Type: Application
    Filed: October 11, 2023
    Publication date: February 1, 2024
    Applicant: OLYMPUS CORPORATION
    Inventor: Susumu YAMASHITA
  • Publication number: 20240033536
    Abstract: Systems and techniques disclosed herein include a light therapy mat having a flexible clear portion, a flexible back portion, a flexible middle portion between the clear portion and the back portion, and a plurality of dual light emitting diodes (LEDs) positioned in the middle portion and configured to emit light at a first wavelength and a second wavelength. The first wavelength may be a red light wavelength or a near infrared light wavelength and the second wavelength may be the other one of the red light wavelength or the near infrared light wavelength.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 1, 2024
    Applicant: Biolight, Inc
    Inventor: Michael BELKOWSKI
  • Publication number: 20240033537
    Abstract: A meridian stimulation device according to the present specification may comprise: a power supply unit that supplies power; a detection unit that detects the cardiac cycle of a user while attached to the skin of the user; at least one pad attached to a predetermined position on the user and including a light emitting unit that emits visible light, and a filter through which the visible light is transmitted; and a control unit that controls the operation of the light emitting unit on the basis of the cardiac cycle of the user.
    Type: Application
    Filed: March 12, 2021
    Publication date: February 1, 2024
    Inventor: Sung Wook BAEK
  • Publication number: 20240033538
    Abstract: A phototherapy assistance method for assisting phototherapy applied to an affected area using a photo-responsive medical agent. The phototherapy assistance method including obtaining blood flow related information regarding blood flow of the affected area, generating progression degree related information regarding progression degree of the phototherapy in the affected area by associating the blood flow related information with the progression degree, and indicating the progression degree related information.
    Type: Application
    Filed: October 10, 2023
    Publication date: February 1, 2024
    Applicant: OLYMPUS CORPORATION
    Inventor: Ryo MACHIDA
  • Publication number: 20240033539
    Abstract: An estimated or predicted dose for radiotherapy treatment may be generated based on a partial dose map including dose information only for one or more regions of interest within a treatment site, by use of a properly trained machine learning system such as a U-Net or a V-Net. Said partial dose map typically set to fulfil clinical goals. A method of training such a machine learning system is also disclosed.
    Type: Application
    Filed: November 29, 2021
    Publication date: February 1, 2024
    Inventors: Mats HOLMSTROM, David ANDERSSON, Gabriel CARRIZO, Adnan HOSSAIN
  • Publication number: 20240033540
    Abstract: A radiation delivery system includes a chair on which the patient may be seated during treatment and a modulating assembly (10) for use in radiotherapy comprises a modulator wheel (15), said modulator wheel being shaped as a rim defining the circumference of a circle or an elliptic shape, and having varying thickness around the circumference, said modulator wheel (15) being arranged in such a way that a beam traveling from a radiation source (13) to a patient will intersect the rim of the modulator wheel, said wheel being arranged to rotate in such a way that the beam will intersect the rim in varying positions around the circumference. The wheel will modulate the energy of the beams passing through material having varying thickness as the modulator wheel rotates.
    Type: Application
    Filed: February 3, 2022
    Publication date: February 1, 2024
    Inventor: Erik TRANEUS
  • Publication number: 20240033541
    Abstract: Methods and systems confirm the treatment focus location of ultrasound energy to be delivered to a patient from a plurality of transducers. The location of focus of treatment ultrasound may be confirmed prior to the start of ultrasound therapy. In some embodiments, ultrasound therapy may comprise delivering treatment ultrasound energy from the treatment ultrasound transducers through the skull to the brain of a patient. Methods for confirming the treatment ultrasound focus location comprise determining receive focus profiles ?x,vi for particular candidate three-dimensional (3D) treatment focus locations and particular assumed ultrasound propagation velocity profiles; performing a pre-treatment (e.g. low-power) ultrasound transmission into the brain of the patient; receiving return signals; and determining the location of treatment focus based at least in part on the received return signals and the receive focus profiles ?x,vi.
    Type: Application
    Filed: July 25, 2023
    Publication date: February 1, 2024
    Inventors: Bhaskar S. RAMAMURTHY, Mallika KERALAPURA, John Douglas MARSHALL
  • Publication number: 20240033542
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Application
    Filed: October 12, 2023
    Publication date: February 1, 2024
    Inventors: Charles A. CAIN, Adam D. MAXWELL, Zhen XU, Kuang-Wei LIN
  • Publication number: 20240033543
    Abstract: The present invention relates to a nose breathing device and, more specifically, to a nose breathing device worn along with a mask to prevent dew condensation from occurring in the mask due to breathing of a user and the occurrence of skin troubles and respiratory diseases.
    Type: Application
    Filed: September 28, 2021
    Publication date: February 1, 2024
    Applicant: SINWOO TECH INDUSTRY LTD.
    Inventor: Kum Jin JEON
  • Publication number: 20240033544
    Abstract: Face masks, including filter masks, having improved stability, including face masks having a sealing member (25) depending from the mask body for engagement with the wearer's face, the mask body comprising a nasal portion (27) for accommodating the nose of the wearer, a mouth portion (26) for accommodating the mouth of the wearer, and cheek portions (28) extending laterally across the wearer's cheeks.
    Type: Application
    Filed: December 9, 2021
    Publication date: February 1, 2024
    Inventors: Matthew James William LEARY, David Simon BOTTOM, Andrew Neil MILLER, Simon Robert PAYNE
  • Publication number: 20240033545
    Abstract: In an illustrative embodiment, systems and methods for verifying safety compliance of a worker positioned on a building structure utilize a motion detector module (MDM) for attaching to a wearable safety harness, where the harness has a lifeline attachment feature for connecting the safety harness to a lifeline anchored to the building structure. The MDM may include a motion sensor for detecting movement of the worker and processing circuitry for detecting, from signals provided by the motion sensor, significant movement indicative of the safety harness being properly worn by the worker and/or proper attachment of the safety harness to a lifeline, and translating the significant movements into compliance information. The MDM may include a proximate sensor for detecting contact between the attachment feature on the harness and a fastener on the lifeline for verifying the compliance information.
    Type: Application
    Filed: April 6, 2023
    Publication date: February 1, 2024
    Applicant: US SAFETY TECHNOLOGIES LLC
    Inventors: George Altemose, Daniel W. Marino, John Gedde
  • Publication number: 20240033546
    Abstract: A fall-protection system including a harness and a fall-protection apparatus with a lifeline bearing a connector configured to be connected to the harness; and, a fall-protection monitoring system with a base unit and with at least one sensor module configured to sense a condition of the connector and to communicate a signal indicative of the condition of the connector to the base unit.
    Type: Application
    Filed: October 9, 2023
    Publication date: February 1, 2024
    Inventors: Lauren K. Carlson, Scott E. Brigham, Christopher W. Coyle, Heidi Lopez-Hidalgo, Jonathan J. Lepp, Stephen D. Shaver, Jeffrey T. Keacher
  • Publication number: 20240033547
    Abstract: An anchor assembly, or mounting for an anchor assembly, particularly for a fall protection apparatus, has first and second mounting limbs connected to be rotatably mounted with respect to one another in order to rotate such that the limbs can be fixed in position at one of a variety of operational positions. The limbs have concentric engagement portions arranged to engage one another in order to permit rotation of the limbs about the rotation axis and inhibiting relative displacement of the limbs in a direction transverse to the rotational axis.
    Type: Application
    Filed: February 2, 2022
    Publication date: February 1, 2024
    Inventor: Jacob Thackeray Squire