Abstract: Methods for treating eosinophilic esophagitis in a pediatric subject are provided. In one aspect, the methods comprise administering to the subject one or more doses of an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody or antigen-binding fragment thereof.

Abstract: Described herein are methods and systems for identifying subpopulations of inflammatory bowel disease (IBD) patients utilizing genetic markers that are associated with severe Crohn's disease. Further provided are therapies useful for treating these subpopulations of IBD patients based, at least in part, on the genetic markers provided herein.

Abstract: Provided are an anti-HVEM monoclonal antibody that binds to human HVEM with high affinity, and inhibits the binding of HVEM to BTLA but promotes the binding of HVEM to LIGHT, and thus can be used alone or in combination with other therapeutic agents to treat solid tumor or hematologic malignancy, and a composition and a method which are related to the antibody.

Abstract: Provided are an anti-PD-L1/anti-4-1BB natural antibody structure-like heterodimeric form bispecific antibody and a preparation thereof. Specifically, provided are an anti-PD-L1/anti-4-1BB bispecific antibody that has natural IgG features, that has no mismatch between heavy and light chains and that is in the form of a highly stable heterodimer, as well as a preparation method therefor. The bispecific antibody can simultaneously bind two target molecules and is more effective in treating complex diseases and has fewer side effects.

Abstract: Chimeric antigen receptors containing CD19/CD20 or CD20/CD19 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

Abstract: Provided herein are anti-CD39 antibodies that inhibit the enzymatic activity of human CD39 and methods of using the same.

Abstract: The present invention provides an anti-SIRP? antibody and an antigen binding fragment thereof, being capable of effectively blocking the binding of SIRP? and CD47, thereby effectively promoting the phagocytosis of macrophages to tumor cells, effectively inhibiting the growth of tumors, and having a good pharmaceutical prospect.

Abstract: The invention provides anti-Jagged antibodies and methods of using the same.

Abstract: Provided herein are multispecific antibodies that selectively bind to TROP2 and effector cell antigens such as CD3, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same.

Abstract: This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, antibody domain, CAR, cell engager, and/or ADC) to a mesothelin polypeptide. For example, binders (e.g., antibodies, antigen binding fragments, antibody domains, CARs, cell engagers, and/or ADCs) that bind to a mesothelin polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having cancer are provided.

Abstract: Disclosed are antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural features. Also disclosed are polynucleotides and vectors encoding such polypeptide complexes; cells, pharmaceutical compositions, and kits containing such polypeptide complexes; and methods of using such polypeptide complexes.

Abstract: Heterodimeric IgA Fc (IgA HetFc) constructs comprising one or more amino acid mutations in the CH3 domain that allow for formation of a heterodimeric Fc having high purity and thermostability. The IgA HetFc constructs may comprise one or more target binding domains. Higher order IgA HetFc multimers comprising multiple IgA HetFc constructs may be prepared in which two of the IgA HetFc constructs are joined by a J chain.

Abstract: The present invention relates to an isolated antibody or antigen-binding fragment thereof that binds to human A2AP. The isolated antibody or antigen-binding fragment according to the present invention i) cross-reacts with rabbit and/or cynomolgus A2AP, ii) does not inhibit human plasmin activity, and iii) increases plasmin mediated clot lysis in the presence of A2AP.

Abstract: A monoclonal antibody or an antibody fragment thereof is provided, in which the monoclonal antibody or the antibody fragment thereof specifically binds to a sugar chain in which a terminal sialic acid residue is bonded to galactose by an ?2,3 bond, and is not dissociated from the sugar chain after the binding to the sugar chain in which the terminal sialic acid residue is bonded to the galactose by the ?2,3 bond.

Abstract: Provided are methods of clinical treatment of diffuse large B-cell lymphoma (DLBCL) (e.g., previously untreated, high-risk DLBCL) in human subjects using a bispecific antibody which binds to CD3 and CD20 in combination with standard of care regimen of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone).

Abstract: Provided herein are stable aqueous pharmaceutical compositions comprising high concentration formulations of a bispecific epidermal growth factor receptor (EGFR)/hepatocyte growth factor receptor (c-Met) antibody and methods of preparing the same. Also provided herein are methods of treating cancer in a subject in need thereof by subcutaneously administering to the subject the stable aqueous pharmaceutical compositions as disclosed herein.

Abstract: Disclosed herein are polypeptides and polypeptides complexes comprising a half-life extending antibody or antibody fragment. In some embodiments, the half-life extending antibody or antibody fragment is a single domain antibody.

Abstract: Provided herein are novel GPC3 binding domains, and antibodies that include such GPC3 binding domains (e.g., anti-GPC3×anti-CD3). Also provided herein are methods of using such antibodies for the treatment of GPC3-associated cancers.

Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-? receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).

Abstract: The present invention relates to a method for producing a starch composition. The method for producing a starch composition according to the present invention comprises the steps of: (a) preparing a raw material mixture which contains a raw starch material, one or more selected from the group consisting of an acid-treated starch and a dextrin, and an aqueous alkaline solution, the raw material mixture having a moisture content of 20 parts by mass or more and 35 parts by mass or less per 100 parts by mass of the raw material mixture; and (b) heat-treating the raw material mixture having a moisture content of 20 parts by mass or more and 35 parts by mass or less obtained in step (a) to a temperature at which the raw material mixture becomes 120° C. or higher and 150° C. or lower. The present invention can provide a starch composition that does not swell or swell less upon heating and that is heat resistant, using a simple method.

Abstract: A method of making a polyolefin nanocomposite including, mixing a zinc-aluminum layered double hydroxide (LDH), and a zirconocene complex in a non-polar solvent to form a first mixture. Prior to the mixing the zirconocene complex is not supported on the zinc-aluminum LDH. The method further includes sonicating the first mixture for at least one hour to form a homogeneous slurry. The method further includes degassing the homogenous slurry and adding at least one olefin gas to form a second mixture. The method further includes adding an aluminoxane catalyst to the second mixture and reacting for at least 10 minutes to form a reaction mixture including the polyolefin nanocomposite. The method further includes separating the polyolefin nanocomposite from the reaction mixture.

Abstract: A rubber material containing a sulfur-modified chloroprene polymer, in which a content X (% by mass) of sulfur constituting the sulfur-modified chloroprene polymer and a total amount Y (% by mass) of a conjugate resin acid and a salt of a conjugate resin acid, on the basis of a total amount of the rubber material, satisfy Expression (A) below, and the total amount Y is 1.00% by mass or more. 13.90X?5.

Abstract: The present invention is directed to a rubber composition for a truck tire, the rubber composition comprising 70 phr to 95 phr of polyisoprene, 5 phr to 30 phr of a polybutadiene rubber having a cis content of less than 60% and being functionalized for the coupling to silica, as well as 40 phr to 80 phr of a filler comprising predominantly silica. Furthermore, the present invention is also directed to a tire comprising such a rubber composition and a truck with said tire.

Abstract: Provided are a polymer polyol dispersion stabilizer, which is prepared by reacting a first polyol having a hydroxyl value (OHV) of 5 to 50 mgKOH/g and an ethylene oxide content of less than 20 wt %, a second polyol having an OHV of 50 to 100 mgKOH/g and an ethylene oxide content of 20 wt % or more, and a reactive unsaturated compound having one or more carbon-carbon double bonds and two or more carbon-oxygen double bonds, and a method of preparing the same.

Abstract: Provided is a polymer composition containing a water-soluble cationic copolymer P2 structured in micro-blocks obtained by radical polymerization of at least one non-ionic monomer and at least one cationic monomer, in the presence of a homopolymer P1 having an average molecular weight between 5,000 and 100,000 daltons, the homopolymer P1 having been prepared from 2-acrylamido-2-methylpropane sulphonate in salified form and in the presence of 200 to 20,000 ppm by weight of 2-methyl-2-propenyl-sulphonic acid in salified form. Related methods are also provided.

Abstract: A polymer particle production method includes: providing (12) one or more vinyl monomers; performing (14) free radical ring-opening polymerization (rROP) of cyclic ketene acetal (CKA) with the one or more vinyl monomers in a first organic solvent with a radical source to obtain a rROP reaction mixture; and emulsifying (16) the rROP reaction mixture in a second organic solvent to produce a plurality of polymer particles.

Abstract: A photocurable resin composition containing a radically polymerizable component (A), a metallic soap (B), and a curing agent (C), wherein the component (A) contains a polyfunctional radically polymerizable compound (A-1) and a monofunctional radically polymerizable compound (A-2), wherein a difference in HSP value between the component (A) and the component (B) is 0 MPa1/2 or more and 8.0 MPa1/2 or less.

Abstract: The disclosure relates to hydrogen mediated anionically polymerized conjugated diene compositions, including homopolymers and copolymers of isoprene and/or butadiene, and processes and compositions for preparing them.

Abstract: A process of manufacturing a composition comprises a particulate drag reducing agent is disclosed. The process comprising: continuously forming a temporary container; introducing an unsaturated monomer component and a radical polymerization component into the temporary container; sealing the temporary container to form a sealed temporary container; allowing the unsaturated monomer component to polymerize in the sealed temporary container to form the drag reducing agent via a radical polymerization reaction, the drag reducing agent having a molecular weight of about 1 million gram/mol to about 50 million gram/mol; and grinding the drag reducing agent to form a composition comprising a particulate drag reducing agent, the particulate drag reducing agent having a particle size of about 1 to about 1,500 microns.

Abstract: A film-forming thermoset coating composition includes: an aqueous medium; and Option 1 and/or Option 2 as follows: Option 1: a compound, such as an oligomeric or polymeric compound, including a plurality of alpha effect based nucleophile functional groups and/or linkages; and a component reactive with at least one of the alpha effect based nucleophile functional groups and/or linkages; Option 2: a compound, such as an oligomeric or polymeric compound including a plurality of n-methylolated alpha effect based nucleophile functional groups and/or linkages. The plurality of alpha effect based nucleophile functional groups and/or linkages include a semi-carbazide functional group and/or linkage, a carbazate functional group and/or linkage, an oxime functional group, an aminoxy functional group and/or linkage, or combinations thereof.

Abstract: The present invention relates to an aqueous polyurethane urea dispersion containing a polyurethane urea and a preparation process and use thereof, especially to the use in the field of coatings, adhesives or sealants, and the products obtained by coating, bonding or sealing with the polyurethane urea dispersion. The polyurethane urea of the aqueous polyurethane urea dispersion containing the polyurethane urea is obtained by the reaction of a system including the following components: a mixture of isocyanates, a polymer polyol, a monofunctional nonionic hydrophilic compound and a potentially anionic or anionic hydrophilic compound; said aqueous polyurethane urea dispersion has a viscosity of 5 s-18 s; relative to the total weight of said aqueous polyurethane urea dispersion, the amount of said polyurethane urea is 30 wt %-50 wt %. The aqueous polyurethane urea dispersion of the present invention has good compatibility with various organic solvents.

Abstract: A polythiol composition according to exemplary embodiments includes a first polythiol compound which provides a maximum peak in a high performance liquid chromatography (HPLC) analysis graph obtained at a wavelength of 230 nm, and a second polythiol compound having a molecular weight greater than that of the first polythiol compound and represented by C9H20S6. A ratio of a peak area of the second polythiol compound to a peak area of the first polythiol compound, which are measured through the HPLC analysis graph at the wavelength of 230 nm, is 0.05 to 5.0%.

Abstract: Polyurethanes are made by curing a reaction mixture containing a polyether polyol that contains residues of a zinc hexacyanocobaltate catalyst complex. The reaction mixture contains certain chelating agents in small quantities. The amount of cobalt that is extractable from the polyurethane is reduced.

Abstract: The present invention relates to a method for preparing an isocyanate containing a non-chlorinated derivative obtained after converting a chlorinated derivative, which is generated in a process for preparing xylylene diisocyanate, into the non-chlorinated derivative by means of a reduction reaction. In particular, the present invention relates to an isocyanate composition comprising the non-chlorinated derivative obtained by the reduction reaction and a polymerizable composition comprising the same.

Abstract: [Problem] To provide a curable composition capable of achieving reduction in viscosity while having a high refractive index when formed into a cured product. [Solution] Disclosed is a curable composition containing an alicyclic epoxy compound (A) and a cationically polymerizable compound (B) having a binaphthyl group. The curable composition preferably contains a monofunctional cationically polymerizable aromatic compound (C), preferably has a viscosity of 30 Pa·s or less at 25° C., and preferably has a refractive index of 1.58 or greater at a wavelength 589 nm when cured.

Abstract: A resin composition for molding and an electronic component device are provided. The resin composition for molding includes: a curable resin; and an inorganic filler including a calcium titanate particle.

Abstract: A powder containing a resin composition for powder additive manufacturing, wherein the resin composition includes an aromatic polyester-based resin; and a 50% impact brittleness temperature of the resin composition measured by the brittleness temperature test described in JIS K7216 at a holding time of 3 minutes, a temperature ticking interval of 5° C., and a temperature range of ?70° C. to 25° is in a range of ?45° C. or higher and 10° C. or lower.

Abstract: A thermosetting binder composition containing water and a water-soluble oligomer ester of at least one carbohydrate selected from reducing sugars, non-reducing sugars and hydrogenated sugars, hydrogenated sugars being selected from the group consisting of erythritol, arabitol, xylitol, sorbitol, mannitol, iditol, maltitol, isomaltitol, lactitol, cellobitol, palatinitol, maltotritol and the hydrogenation products of starch hydrolysates or of hydrolysates of lignocellulosic materials; at least one diol; and at least one polycarboxylic acid, the binder composition having a solid matter content ranging between 40% and 80% by weight, the water-soluble oligomer ester accounting for at least 70% by weight of the solid matter of the thermosetting binder composition, and the ratio of the number of hydroxyl groups of all the diols to the number of hydroxyl groups of all the diols and carbohydrates ranging between 5% and 50%.

Abstract: A coating agent including a polyrotaxane represented by Formula (1): wherein R1 is a hydrogen atom or a methyl group, m is 1 to 2000, and n is 10 to 500, is a cyclodextrin in which at least one hydroxyl group is modified with R2, and R2 is a C1-6 alkyl group.

Abstract: Linear polymers and copolymers having tunable coefficients of thermal expansion can be derived from dibenzocyclooctene-based monomers. The dibenzocyclooctene-based monomer can comprise a dibenzocyclooctene or a heterocyclic derivative of dibenzocyclooctene. For example, the linear polymer can comprise a polymer or copolymer of a dibenzocyclooctene-based moiety and a polyester, polyamide, polyimide, polyurethane, or epoxy.

Abstract: A polyamic acid resin is copolymerized including: at least one diamine; at least one acid dianhydride; and polyhedral oligomeric silsesquioxane, and a transparent polyimide film is formed using the polyamic acid resin. The transparent polyimide film secures both excellent optical and mechanical properties through organic-inorganic hybrid formation, thus being applicable as a cover window for display devices.

Abstract: A functionalized macromolecule includes a hydrogenated interpolymer portion, a non-hydrogenated polymer portion, and the radical of a functional coupling agent covalently bonded to and linking those portions. The functional group of the coupling agent exhibits interactivity with silica. The interpolymer can include vinyl aromatic mer and conjugated diene mer, with at least some of the latter, typically at least 50 mole percent, having been hydrogenated.

Abstract: The invention relates to organopolysiloxanes comprising at least one structural unit with at least one C8-28 alkyl group and at least one urea group, a method for their preparation, a preparation comprising the organopolysiloxane, and the use as a hydrophobizing agent.

Abstract: A composition includes thermoplastic polymers and at least one organosilicon compound of the general formula R3-a-b(OR1)aR2bSi[OSiR2]p[OSiRR2]q[OSiR22]rOSiR3-a-b(OR1)aR2b (I), wherein a+b is ?3 and at least one R2 radical is present.

Abstract: A temporary high-temperature-resistant dispersing agent, and a preparation and a use method thereof. The temporary high-temperature-resistant dispersing agent is a block high-molecular polymer prepared by a one-step reaction from polysiloxane containing an amino group. The prepared block high-molecular polymer may be directly used as a dispersant; the block high-molecular polymer may also be used as a basic formula and used as the dispersant after other auxiliary compositions are added; and the block high-molecular polymer may also be used in combination with one or more other dispersion auxiliaries and/or surfactants to meet dispersion requirements in various special occasions.

Abstract: Mixture compositions contain A) crosslinked organopolysiloxanes having organopolysiloxane units linked by a building block containing polyether groups, and B) crosslinked organopolysiloxanes having organopolysiloxane units bridged by a bridging siloxane. The mixture compositions are useful, for example, as an emulsifier, for stabilizing formulations, and for dispersion of solid pigments.

Abstract: The present disclosure relates to a preparation method of a super absorbent polymer. More specifically, it relates to a preparation method of a super absorbent polymer, which can improve a drying efficiency in the preparation process and realize excellent absorption-related properties of the prepared super absorbent polymer by using a specific inorganic material in the reassembly process.

Abstract: The present invention provides a method of producing polymer particles by precipitation polymerisation, the method comprising: providing a reaction solution comprising (i) solvent, (ii) a photo-active compound that upon being subjected to a wavelength of light forms two o-quinodimethane structures, and (iii) a multi-dienophile compound; subjecting the reaction solution to the wavelength of light, which promotes step-growth Diels-Alder polymerisation of the photo-active and multi-dienophile compounds; wherein as a result of the step-growth Diels-Alder polymerisation polymer precipitates from the reaction solution and self-assembles into the polymer particles.

Abstract: Provided herein is a composite material, and a method of producing the composite material. The method of producing the composite material includes providing a first material comprising turbostratic graphene, providing a second material comprising rubber, mixing the first material and the second material, and producing a turbostratic graphene rubber composite.

Abstract: A method for nanomaterial formation and distribution within a matrix material that includes: preparing a gel matrix; patterning a reactive group within the matrix material; binding a seed material to reactive group within the matrix material, the seed material selected from a first set of gold nanomaterials, silver nanomaterials, and copper nanomaterials; binding a precursor reagent selected from materials to the seed material; adding a chalcogen to form a precursor reagent chalcogenide at sites of the precursor reagent via an ion exchange; adding final compound and optionally a ligand in solution and facilitating cation exchange replacing the precursor reagent chalcogenide with the final compound to form a nanomaterial within the matrix material.