Abstract: Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

Abstract: Described herein are injectable compositions composed of one or more polycationic polyelectrolytes and anionic counterions, one or more one polyanionic polyelectrolytes and cationic counterions, and a transient contrast agent. The injectable compositions have an ion concentration that is sufficient to prevent association of the polycationic polyelectrolytes and the polyanionic poly-electrolytes in water. Upon introduction of the composition into a subject, a solid is produced in situ. The transient contrast agent diffuses out of the solid over hours or days providing temporary contrast and does not remain in the subject unlike permanent contrast agents. This feature provides sufficient time for the clinician to perform medical procedures prior to the diffusion of the contrast agent out of the solid. The viscosity of the injectable compositions can be varied depending upon the application of the injectable composition.

Abstract: The present inventions relates to bioresorbable sealing powder comprising: water-soluble electrophilic polymer carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups under the formation of a covalent bond; water-soluble nucleophilic cross-linker carrying at least 2 reactive nucleophilic groups that, in the presence of water, are capable of reacting with the reactive electrophilic groups of the electrophilic polymer under the formation of a covalent bond between the electrophilic polymer and the nucleophilic cross-linker; water-absorbing particles containing at least 50% by weight of said water-absorbing particles of water-insoluble polymer containing reactive nucleophilic groups; water-soluble dispersant that is solid at 20° C., said water-soluble dispersant being selected from monosaccharides, disaccharides, oligosaccharides, sugar alcohols and combinations thereof.

Abstract: Disclosed is a composition for treating a wound including a dermis-derived extracellular matrix and a method for preparing the composition. By using the composition for treating a wound according to the present invention, the composition can be applied to wounds of various sizes and depths by increasing the viscosity of the composition, the composition is well coagulated without falling off for a certain period of time after application to a wound surface, and the composition can promote recovery.

Abstract: The present invention provides an artificial dressing and a use of the artificial dressing for promoting wound healing. The artificial dressing includes a gelatin and a fungal extract.

Abstract: In one embodiment, the present invention provides a composition, wherein the composition is a porous scaffold, wherein the pores of the scaffold are from 1 to 500 microns, the composition comprising: a) a cross-linkable protein selected from the group consisting of collagen and gelatin; b) a cross-linker which induces cross-linking of the cross-linkable protein; and c) a liquid.

Abstract: Provided herein are methods for preparing fibrillar polymeric scaffolds, compositions comprising fibrillar polymeric scaffold, and an apparatus comprising two concentric cylinders, a rotating inner cylinder powered by a motor, and a stationary outer cylinder.

Abstract: The disclosure herein relates to photoinitiated dermal fillers, hyaluronic acid-rhCollagen double crosslinked dermal fillers and hyaluronic acid-rhCollagen semi interpenetrated network, each comprising plant-derived human collagen, as well as methods of using the same.

Abstract: The present invention method for manufacturing a tissue regeneration patch includes: A) preparing a micronized adipose tissue extract; B) injecting the micronized adipose tissue extract into a mold of a predetermined shape; C) cooling the mold into which the adipose tissue extract is injected at a temperature between ?25° C. and ?10° C.; and D) removing the mold to obtain a tissue regeneration patch.

Abstract: Materials, methods, and systems for biorthogonal ligation of hydrogel labels to crosslinked-natural polymer hydrogels are provided. A heterobifunctional linker includes a peptide-reactive activated functional group on the heterobifunctional linker, including an activated amine-reactive functional group, an activated thiol-reactive functional group and being reactive with a hydrogel comprising a crosslinked natural polymer. The heterobifunctional linker also includes a photocaged reactive group including a photocaged hydroxylamine, a photocaged alkoxyamine, a photocaged hydrazide, a photocaged amine, a photocaged tetrazine, or a photocaged alkyne-containing moiety. The peptide-reactive activated functional group does not include an azide.

Abstract: A method of producing a cryogel-based multicompartment 3D scaffold is herein disclosed. The method comprises the steps of: a) providing a first frozen polymeric layer on a refrigerated support kept at subzero temperature; b) providing subsequent polymeric layers to obtain a stack of polymeric layers by possibly modulating the subzero temperature of the refrigerated support; c) optionally incubating the final polymeric structure at subzero temperature; and d) placing the produced cryogel at a temperature above 0° C., wherein each subsequent layer i) is deposited on the previous one after freezing of this latter; ii) is deposited on the previous one before the complete polymerization of this latter; and iii) is deposited with a temperature higher than the freezing temperature of the previously deposited layer. Cryogel scaffolds obtained from said method are also disclosed.

Abstract: Described are methods for embedding one or more therapeutic agents into vascular grafts and other scaffold-based devices, and methods of implanting vascular grafts comprising tubular scaffolds into subjects. The tubular scaffolds comprise hydrogel nanofibers that have internally aligned polymer chains and may contain one or more therapeutic agents.

Abstract: An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.

Abstract: The present disclosure relates to hydrophilic silicone rubber serving as a medical catheter and a preparation method and application thereof. The hydrophilic silicone rubber is obtained from polysiloxane containing a nitrile group through a formula design and ultraviolet light irradiation, and can be applied to preparation of silicon rubber medical catheters. The hydrophilic silicone rubber prepared in the present disclosure is cross-linked by ultraviolet irradiation, without a transition metal catalyst, and without metal ion residues. The hydrophilic silicone rubber prepared in the present disclosure can be directly taken as a medical catheter for use, or as a basic formula for use after adding other auxiliary ingredients, so as to meet special needs of various medical places.

Abstract: A method of creating a drug eluting system for hernia repair in a patient is provided. The includes providing an implantable mesh for hernia repair comprised of at least one of polytetrafluoroethylene fibers or polytetrafluoroethylene filaments, wherein the at least one of the polytetrafluoroethylene fibers or polytetrafluoroethylene filaments is at least one of directionally or non-directionally oriented, positioning a pharmaceutical agent on the implantable mesh, and coating at least a portion of the at least one of the polytetrafluoroethylene fibers or polytetrafluoroethylene filaments and the pharmaceutical agent with a polymer, wherein the implantable mesh is configured to be positioned in the body of the patient during the repair of the hernia and the pharmaceutical agent elutes from the implantable mesh into the body of the patient at the site of the hernia repair.

Abstract: An embodiment includes an apparatus comprising: a shape memory polymer (SMP) foam having an outside surface; and a membrane that encapsulates at least 50% of the outside surface of the SMP foam; wherein (a) the SMP foam includes a thermoset SMP, and (b) the membrane includes a thermoplastic polymer. Other embodiments are addressed herein.

Abstract: The present invention relates to the technical field of medical devices, and in particular to an orthopedic internal fixation implant medical device, including an iron matrix and a filling material including polylactic acid and an alkaline substance. The polylactic acid has a weight-average molecular weight of Mw kDa, the alkaline substance includes a metal element, the mass ratio of the metal element in the alkaline substance to the polylactic acid is p, and the p and the Mw satisfy a formula of 2Mw{circumflex over (?)}?0.8?p?30Mw{circumflex over (?)}?0.5. The orthopedic internal fixation implant medical device, with good mechanical properties, can control local pH values and induce bone healing.

Abstract: A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: Si: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.

Abstract: The present disclosure relates to a medical system for specifying adjustable setting of a blood treatment apparatus having a calculation device with an input interface for entering and/or reading in the results determined by a diagnostic device for executing a retinal vessel analysis of a patent, respectively; an output interface for outputting at least one technical parameter value for the treatment of the patient and/or outputting at least one target treatment parameter value for a treatment of the patent using the blood treatment apparatus, and/or for outputting suggested changes of existing pre-set or pre-settings for the technical parameter value and/or for the target treatment parameter value.

Abstract: A container for warming fluids comprises an inlet port, an outlet port, a fluid conduit configured for fluidly communicating the inlet and outlet ports, and deflection sections. The fluid conduit has a non-constant maximum width in a direction of fluid flow through the fluid conduit. The deflection sections further comprise an entry section and an exit section, each respective exit section being arranged downstream, in the direction of fluid flow, from each respective entry section. The maximum width of the fluid conduit decreases along the direction of fluid flow through the entry section over a first distance and the maximum width of the fluid conduit increases along the direction of fluid flow through the exit section over a second, different distance. A blood treatment apparatus including the above-described container is also provided.

Abstract: A manifold assembly for a peritoneal dialysis apparatus, comprises: a casing delimiting internally a first compartment and a second compartment; a yielding pump tube having a first end connected or connectable to the first compartment and a second end connected or connectable to the second compartment. The yielding pump tube extends outside the casing to be coupled to a peristaltic pump of a cycler of a peritoneal dialysis apparatus. A first pump port and a second pump port are placed on a first side of the casing and ports are placed on a second side of the casing, opposite the first side.

Abstract: A manifold assembly for a peritoneal dialysis apparatus, comprises: a casing delimiting internally a first compartment and a second compartment; a yielding pump tube having a first end connected or connectable to the first compartment and a second end connected or connectable to the second compartment. The yielding pump tubes extends outside the casing to be coupled to a peristaltic pump of a cycler of a peritoneal dialysis apparatus. The second compartment delimits expansion chambers configured to attenuate pressure pulsations from the peristaltic pump.

Abstract: A method for calibrating a peristaltic pump in a medical apparatus comprises: rotating the peristaltic pump of a predetermined rotation to pump a liquid from a fluid source from a first compartment into a second compartment of a manifold assembly, raising a level of the liquid in the second compartment and compressing air in an air buffer volume of the manifold assembly; measuring a pressure of air in the air buffer volume; calculating, from the measured pressure, a variation of liquid volume in the second compartment due to the rotation of the peristaltic pump; calculating, from the variation of liquid volume and the predetermined rotation, a stroke liquid volume of the peristaltic pump.

Abstract: In alternative embodiments, provided are solutions for peritoneal dialysis for use for maintaining or restoring the removal of small solutes and fluids in subjects with end-stage renal disease and/or congestive heart failure. In alternative embodiments, such solutions comprise carnitine, xylitol and at least one of glucose, glycerol and polydextrin.

Abstract: Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration.

Abstract: An apparatus for shunting blood includes a flow-indication chamber shaped to define an entry port and an exit port, and one or more moveable objects disposed within the flow-indication chamber and configured to move in response to a flowing of the blood from the entry port to the exit port. At least a portion of a wall of the flow-indication chamber is transparent so as to expose the moveable objects to sight. Other embodiments are also described.

Abstract: Methods and devices for separating components from multi-component fluids are provided. A method for collecting a blood component includes drawing whole blood into a centrifuge, spinning the centrifuge to cause centrifugal force to act on the whole blood to separate the whole blood into a least a first blood component and a second blood component that is different from the first blood component, extracting the first blood component from the centrifuge, detecting when the second blood component is about to be extracted from the centrifuge, and after the second blood component is detected and while the centrifuge continues to spin, flowing the separated first blood component back towards the centrifuge to move at least the second blood component from the centrifuge.

Abstract: A drainage system, the drainage system comprising a container having an interior and a mouth, the mouth comprising an outer surface and an opening, a frangible seal covering the opening, a cap secured to the mouth and in fluid communication with a drainage line, the cap having an inner surface configured to engage with the outer surface of the mouth, an O-ring located at least partially between the outer surface of the mouth and the inner surface of the cap and configured to form a fluid seal between a space defined by the cap and the space located externally of the drainage system, and a retaining ring circumferentially engaging the cap.

Abstract: Embodiments disclosed herein are directed to a dynamic pressure response system for fully automated clearing of dependent loops from a fluid drainage system. Fluid drainage systems include a flexible drainage tube providing fluid communication with a collection container. Dependent loops can form within the tube leading to pooling of urine and provide an increased risk in CAUTI. Dynamic pressure response systems can automatically detect the presence of dependent loops and provide a low-rate positive air pressure to clear the columnized fluid. Further, the system can automatically detect mixed fluid states when a noise level of pressure signals increases, the system can then provide high-rate positive air pressure to clear mixed fluid state liquid from the tube lumen.

Abstract: The present disclosure generally relates to a removable enclosure for a mobile negative pressure wound therapy (NPWT) device, where the enclosure is arranged to reduce unwanted noise from a pump comprised with the negative pressure pump. The enclosure is specifically useful when operating the NPWT device during nighttime.

Abstract: A negative pressure assembly includes a drape, a sealing element, a reactor, and a mechanical pump assembly. The drape covers a dressing site on a patient and seals against the skin upon application of a vacuum while maintaining a negative pressure underneath the drape. When applied to the skin, the sealing element cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element. The reactor is located with respect to the drape and the sealing element to be in fluid communication with the enclosed volume when the drape is covering the dressing site and is configured to react with and consume a selected gas found in air. The mechanical pump assembly is connectable to the enclosed volume and has a pump chamber in fluid communication with the enclosed volume to draw air from the enclosed volume into the pump chamber.

Abstract: This holding device comprising a supporting plate, the supporting plate having an upper face, a lower face opposite the upper face, a plurality of openings arranged according to a predetermined pattern and each configured to receive a barrel of one of the medical containers, plurality of reinforcing ribs protruding from at least one of the upper and lower faces and extending between adjacent openings of the plurality of openings, and the plurality of reinforcing ribs comprises at least one oblique rib extending obliquely relative to a longitudinal direction of the supporting plate from one side to another side of the supporting plate and between two different pairs of adjacent peripheral openings.

Abstract: A fluidics control system includes a first processor, a valve system including a first vacuum valve configured for connection between a first catheter and a first source of vacuum, a first saline valve configured for connection between the first catheter and a first source of saline, and a first contrast valve configured for connection between the first catheter and a first source of contrast media, and a first contrast control for initiating introduction of contrast media into the first catheter. The first processor is configured to open the first contrast valve, and close the first saline valve and the first vacuum valve in response to actuation of the first contrast control.

Abstract: A cassette for use with a pumping apparatus having a pumping system for engaging a pump set includes a cassette body configured for releasable attachment to the pumping apparatus to mount the cassette on the pumping apparatus. The cassette body has at least one mounting formation. At least one identification member is mounted on the cassette body by the mounting formation of the cassette body. The identification member and mounting formation are formed to mount the identification member in any one of a plurality of predetermined orientations. Each predetermined orientation indicates a different functional configuration of the pump set.

Abstract: Disclosed herein is a double reservoir configuration for a pumping mechanism for a drug delivery device wherein one reservoir is rigidly fixed to a housing of the device and the other reservoir moves linearly translates with respect to the fixed reservoir. To avoid having either the input fluid port or the output fluid port moves as the second reservoir linearly translates, one port is in fluid communication with the fixed reservoir and a second fluid port is in communication with the moving reservoir via a hollow tube supporting a static plunger disposed within the moving reservoir. This arrangement provides for the added benefit of allowing air trapped within either of the reservoirs to be almost completely removed as the pump mechanism is filled with the fluid.

Abstract: A system for at least partial closed-loop control of a medical condition is disclosed. The system includes at least one medical fluid pump. The medical fluid pump including a sensor for determining the volume of fluid pumped by the pump. Also, at least one continuous analyte monitor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor. The processor includes instructions for delivery of medical fluid based at least on data received from the at least one continuous analyte monitor.

Abstract: Provided is a drug injection device including: a base body; a needle assembly mounted on the base body; a reservoir mounted on the base body and fluidly connected with the needle assembly; a driving unit including a rod that is engaged with a plunger disposed inside the reservoir and moves along the reservoir, and a driving wheel that transmits a driving force to the rod; a clutch unit disposed between the rod and the driving wheel; and a trigger member rotatably disposed on one side of the base body and coupling the rod with the driving wheel by pressing the clutch unit.

Abstract: A flow controller having an internal tubing is provided. The flow controller may include an upper housing having a plurality of graduations, a lower housing engaged with and slidably coupled to the lower housing, and a cavity defined between the upper and lower housings for accommodating at least a portion of internal tubing. The flow controller may further include a flexible clamp having an upper section mounted in the upper housing and a lower section slidably disposed in the lower housing. The upper and lower housings may be slidably coupled relative to each other to transition the internal tubing from (i) an open position where a lumen of the internal tubing is uncompressed by the flexible clamp to (ii) a closed position where the lumen of the tubing is at least partially constricted by the flexible clamp.

Abstract: A method includes measuring a fluid pressure of fluid in a fluid supply line of an infusion pump. The fluid pressure includes a motor pressure and a patient pressure. The method also includes determining the patient pressure. The determining includes removing, by an adaptive filter, to remove the motor pressure from the measured fluid pressure. The removing includes generating a predicted motor pressure based on the current of the motor, generating an error signal based on a comparison between the predicted motor pressure and the measured fluid pressure, and removing the motor pressure from the measured fluid pressure when an error value indicative of the error signal is less than an error threshold. The method also includes adjusting, based on the patient pressure, a setting of the infusion pump. Related methods and articles of manufacture, including apparatuses and computer program products, are also disclosed.

Abstract: A syringe-based device includes a housing and an actuator mechanism including a first member and a second member. The first member includes a syringe body and a plunger, the plunger being movably disposed within the syringe body. The second member includes a second member plunger seal and a valve operably and selectively coupled to the second member plunger seal such that the valve is positioned proximal of the second member plunger seal. The device also includes a first fluid reservoir and a second fluid reservoir. The device transitions from a first configuration to a second configuration in which the first type of fluid is expelled from the first fluid reservoir, to a third configuration in which the second type of fluid is expelled from the second fluid reservoir through the valve.

Abstract: Autoinjectors and methods of injection are described that feature release mechanisms and/or end-of-dose sound which can operate in conjunction with a powered plunger to efficiently inject a controlled dose from a syringe.

Abstract: Drug delivery devices are provided having a needle assembly portion and a drug device portion, where the needle assembly portion is removably coupleable to the drug device portion. In some embodiments, the needle of the needle assembly may be moveable between a retracted position and an extended position for piercing into a subjects skin.

Abstract: A common injection device is assembled with an injection needle containing a drug, and the common injection device has a needle bushing, a drug-information providing portion disposed on the needle bushing, and an injection propulsion mechanism detachably connected to the needle bushing. The needle bushing and the drug-information providing portion are pre-installed on the injection needle, the drug-information providing portion provides readable drug information of the drug, and a user can confirm that the drug is correct through the readable drug-information providing portion. Then, the injection propulsion mechanism is used to connect the needle bushing, and the injection action is performed according to the drug information to ensure the safety of injection.

Abstract: Provided herein is a pre-filled manual apparatus and methods of use thereof. The pre-filled manual apparatus includes a repository corticotropin pharmaceutical composition for an adult patient ?18 years old in need thereof to deliver a one-time use dose only. The manual injector apparatus is capable of being stored at room temperature for up to 24 hours prior to administration and the repository corticotropin pharmaceutical composition is a naturally sourced complex mixture comprising N-25 deamidated porcine ACTH (1-39).

Abstract: A glass syringe barrel is provided that has a bottom end and a top end with a cone region, a shoulder region, a body region, and a flange region therebetween. The glass syringe barrel is configured so that f(x) defines an absolute value of a vertical distance between any point of a first outer contour and a straight line fo at a position x, with f(x)=0 at point P1, wherein x is a horizontal distance between any given point on the straight line fo and point P0 at which the straight line fo crosses a line L1 that runs parallel to the longitudinal axis and that touches an outer surface of the body region, and a maximum value for the term f(x) in a range from x=P0 to x=P1 is f(x)max determined at position xmax.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: The present invention relates to a syringe and medical kit, which allow for doses of epinephrine of 0.15 mg or 0.15 mL, 0.3 mg or 0.3 mL, and 0.5 mg or 0.5 mL, the most commonly prescribed doses which are utilized today in treating anaphylaxis or other allergic reactions. Currently, existing syringes may include many markings of ten or more dosages. Although these prior art syringes are useful, it is difficult to use them for a patient who must quickly identify a correct dose level among many other marks. The above problem can be addressed by a syringe design which has only a few dosage markings, which correspond to commonly used standard dosages for children and adults. When used with a standard concentration of 1:1000 epinephrine solution, such a device can rapidly provide a known quantity of medicine to a patient who is in urgent need of it.

Abstract: A multi-beveled needle point geometry for hypodermic needles such as pen needles. A proximal bevel is formed at a first angle of inclination, a pair of intermediate bevels at a second angle of inclination, and a pair of distal bevels at a third angle of inclination and differing angles of rotation. The second angle of inclination is substantially different than the first angle of inclination to define a marked apex at the intersections between the proximal bevel and the intermediate bevels. At least one smooth transition is typically provided between adjacent bevels, between a bevel and an outer surface of the needle, and/or between a bevel and the lumen of the needle.

Abstract: A catheter assembly includes: a catheter including a circumferential wall and a distal opening; an inner needle inserted through the catheter, the inner needle having a sharp needle tip at a distal end of the inner needle; and a deflection suppression mechanism that supports the inner needle via the catheter to suppress deflection of the inner needle, the deflection suppression mechanism including a contact support portion that is configured to support the catheter when the catheter is advanced with respect to the inner needle. The circumferential wall of the catheter includes one or more side holes. In an initial state before the catheter is advanced with respect to the inner needle, a distal-most one of the one or more side holes is in a distal portion of the catheter, and the contact support portion is proximal of a proximal-most one of the one or more side holes.

Abstract: An embodiment provides a medical needle unit with an air filter part for preventing air injection, the medical needle unit being designed to prevent qualitative deterioration of ultrasound images due to unexpected air injection in ultrasound-guided procedure and operation environments.