Abstract: Systems and methods are provided herein for treating a patient in cardiogenic shock. An intravascular heart pump system is inserted into vasculature of the patient. The heart pump system has a cannula, pump outlet, pump inlet, and rotor. The heart pump system is positioned within the patient such that the cannula extends across the patient's aortic valve, the pump inlet is located within the patient's left ventricle, and the pump outlet is located within the patient's aorta. Data related to time-varying parameters of the heart pump system is acquired from the heart pump system. A plurality of features are extracted from the data. A probability of survival of the patient is determined based on the plurality of features and using a prediction model. The heart pump system is operated to treat the patient.

Abstract: An electrotherapy appliance for introducing a therapeutic electrical pulse into the skin of a patient includes a pulse source for outputting a pulse voltage and an output capacitor, which can be placed on the skin of the patient and is fitted with a first capacitor electrode connected to a first terminal of the pulse source and fitted with a second capacitor electrode connected to a second terminal of the pulse source, in order to convert the pulse voltage into the therapeutic pulse. A position sensor is provided for detecting a position of the output capacitor on the skin while the therapeutic pulse is being delivered.

Abstract: The present disclosure generally provides methods of implanting an implantable device in contact with a brain of a subject. Also provided are kits and systems for the implantation of one or more implantable devices.

Abstract: The present invention relates to a flexible electrode carrier for neurostimulation, in particular for Cortical and/or Deep Brain Stimulation, having a proximal end and a distal end, wherein the flexible electrode carrier comprises at least two zones each comprising a plurality of electrodes.

Abstract: Disclosed are systems and methods that include inserting an electrical lead having a proximal portion configured to engage a controller, the controller configured to cause one or more electrodes to generate therapeutic energy and a distal portion coupled to the proximal portion. The distal portion includes one or more electrodes that are configured to generate the therapeutic energy for biological tissue of a patient. The method also includes fitting a lead anchor on a proximal part of the electrical lead, an exterior of the lead anchor comprising fixation features for facilitating fixation to patient tissue and securing the electrical lead to patient tissue by fixating the lead anchor to the patient tissue.

Abstract: Systems, methods, devices and computer software for delivering electrical stimulation to biological tissue are described. In some implementations, an electrical lead for implantation in a patient can include a distal portion with electrodes that are configured to generate therapeutic energy for biological tissue of the patient, such as the heart or pericardium. The distal portion can include an electrode extension having a tip electrode, the electrode extension configured to facilitate contact of the tip electrode with biological tissue of the patient when the lead is in a deployed configuration. A distal part of the lead can be configured to include a heel portion, a bend in a proximal part, and/or a bend in a distal part, to facilitate contact of an electrode located on the heel portion with biological tissue of the patient when the lead is in a deployed configuration.

Abstract: The present invention discloses a brain stimulation systems, devices and methods to: induce lucid reality; improve sleep; improve motor performance; improve learning; enhance gaming activities; improve mental health; and any combination thereof. The system comprises at least one head mounted device; at least one power supply unit; at least one communication unit; at least one microcontroller; at least one external device; and at least one cloud-based storing device.

Abstract: The skin care method of skin beauty device according to the present invention can lower the skin barrier by charging negative potential to skin through mist spraying, expand pores and reproduce the skin through temperature stimulation and irradiation of red light after cleaning wastes from inside the pores, and more effectively enable cosmetics to be introduced into the skin through EP function and vibration function. Furthermore, the skin care procedures can be finished by implementing the pore shrinkage through cooling stimulation and antimicrobial action through blue light irradiation. The more efficient skin care can be realized through adequate implementation of thus-mentioned series of skin care functions according to the order, compared to individual implementations of various functions of the skin beauty device, whereby users not accustomed to the skin care can easily care the skin.

Abstract: A laryngeal pacemaker is configured for external placement on skin of a patient to produce respiration stimulation signals. An implantable stimulation electrode delivers the respiration stimulation signals to adjacent target neural tissue for vocal fold abduction during respiration of the recipient patient. A triaxial accelerometer produces a body motion signal reflecting energy expenditure of the recipient patient. A respiration sensor includes a flexible skin-transferrable printed tattoo electrode having a tetrapolar configuration for impedance pneumography measurement to produce a sensed respiration signal for the laryngeal pacemaker. The respiration sensor is configured for transfer and release by guided placement from a sensor applicator to the skin at the angulus sterni of the recipient patient.

Abstract: Method and apparatuses for reducing bleeding in a hemophilic patient are described herein. Vagus nerve stimulation augments clotting at the site of injury without precipitating systemic thrombosis, and may be applied to reduce traumatic bleeding in hemophilia A subjects. In particular, vagus nerve stimulation may be applied to reduce traumatic bleeding in hemophilia A subjects that have not received a clotting factor.

Abstract: Systems, methods, and devices for treating chronic pains effectively are disclosed. The system is based on the use of randomly generated non-pulsed waveform between a frequency of 5 Hz to 2 KHz. The waveforms generated have characteristics which are pre-defined or based on the input and feedback provided by the patient and/or by the clinician, at the same time conforming to certain safety rules and precautions ensuring patient safety. This disclosure also describes a novel approach of implementing a secure memory stick which can be used to exchange data securely between one device and another device where device could be the device mentioned earlier, an off-line server, or a PC.

Abstract: Disclosed herein are devices, systems, and methods for treating a medical condition through a coordinated stimulation of two or more target nerves. In some embodiments, the stimulation comprises electrical stimulation delivered to a patient. In some embodiments, the coordinated stimulation comprises the two or more target nerves being stimulated in parallel, in series, a combination thereof, or any coordinated temporal sequence. In some embodiments, the stimulation delivery is contingent on an electrode placement confirmation via one or more electrode monitors. In some embodiments, the delivered electrical stimulation comprises one or more stimulation parameters configured to be adjusted based on feedback from the patient. In some embodiments, the one or more stimulation parameters are automatically randomized over a normal distribution.

Abstract: This invention relates to a closed-loop adaptive AC stimulation neural network control method and system, involving the technical field of AC stimulation neural regulation. This system is composed of an individualized navigation module, AC stimulation module, EEG acquisition module and adaptive coupling module. After the magnetic resonance image and functional magnetic resonance image of the regulation object are input into the individualized navigation module, the functional connectivity network is generated to finalize regulatory targets. The position of stimulating electrodes and the magnitude of the stimulating current are determined according to the target to be regulated. The stimulating frequency is determined according to the EEG of the regulation object and then input into the AC stimulation module for regulation.

Abstract: A system for magnetic induction communication between an implantable component and an external component, including an implantable component, the implantable component including magnetic induction radio communication circuitry connected to an implantable antenna arrangement of the implantable component, the implantable antenna arrangement comprising at least two coil antennas for radio communication and an external component including magnetic induction radio circuitry connected to a coil antenna of the external component, wherein the system is configured so that when the implantable antenna arrangement of the implantable component is implanted between a skull and skin of a human and the external component is worn on the head of the component during normal use the magnetic induction communication link between the external and the implantable component is active and effectively operating.

Abstract: The present invention provides, inter alia, methods, apparatus, and systems useful for ameliorating impulse control disorders known to be extremely disabling and common to many neurological and psychiatric conditions using closed-loop (responsive) neuro stimulation.

Abstract: A system and/or method to control operation of an implantable medical device in response to a monitored gravity vector.

Abstract: Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.

Abstract: A system may include at least two coil circuit branches, a driver, and a controller. Each of the at least two coil circuit branches may include a coil and a switch. The at least two coil circuit branches may be connected in parallel. The driver may be connected to the at least two coil circuit branches that are connected in parallel. The driver may be configured to drive the coils in the at least two coil circuit branches. The controller may be configured to independently control the switch in each of the at least two coil circuit branches to independently control whether the driver is electrically connected to drive the coil in the corresponding coil circuit branch. Some system embodiments include a dedicated driver for each of the coil circuit branches, and a controller configured to independently control the drivers to independently control whether individual coils are driven.

Abstract: Systems, devices, methods, and techniques are described for using evoked compound action potential (ECAP) signals to monitor lead position and/or detect lead migration. An example system includes sensing circuitry configured to sense an ECAP signal, and processing circuitry. The processing circuitry controls the sensing circuitry to detect, after delivery of an electrical stimulation pulse, a current ECAP signal, and determines one or more characteristics of the current ECAP signal. The processing circuitry also compares the one or more characteristics of the current ECAP signal to corresponding one or more characteristics of a baseline ECAP signal, and determines, based on the comparison, a migration state of the electrodes delivering the electrical stimulation pulse. Additionally, the processing circuitry outputs, based on the migration state, an alert indicative of migration of the electrodes.

Abstract: Provided herein is a method of blocking a nerve or neuron by applying an electrical stimulation to the nerve or neuron, wherein the electrical stimulation is of an intensity below the excitation threshold of the nerve or neuron for a length of time sufficient to produce a block of nerve conduction or neuron excitation.

Abstract: An extra-cardiovascular implantable cardioverter defibrillator (ICD) system receives a cardiac electrical signal by an electrical sensing circuit via an extra-cardiovascular sensing electrode vector and senses cardiac events from the cardiac electrical signal. The ICD system detects tachycardia from the cardiac electrical signal and determines a tachycardia cycle length from the cardiac electrical signal. The ICD system determines an ATP interval based on the tachycardia cycle length and sets an extended ATP interval that is longer than the ATP interval. The ICD delivers ATP pulses to a patient's heart via an extra-cardiovascular pacing electrode vector different than the sensing electrode vector. The ATP pulses include a leading ATP pulse delivered at the extended ATP interval after a cardiac event is sensed from the cardiac electrical signal and a second ATP pulse delivered at the ATP interval following the leading ATP pulse.

Abstract: A medical device is configured to determine time intervals between consecutive cardiac events sensed from a cardiac electrical signal, increase a value of a tachyarrhythmia interval count in response to each of the determine time intervals detected as a tachyarrhythmia interval. The device is further configured to detect normal sinus rhythm events and the decrease the value of the tachyarrhythmia interval count in response to a threshold number of detected normal sinus rhythm events.

Abstract: A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.

Abstract: A method for controlling an adaptive pacing therapy that includes utilizing one or more processors to perform measuring an atrial-ventricular (AV) interval corresponding to an interval between an atrial paced (Ap) event or an atrial sensed (As) event and a sensed ventricular (Vs) event, setting an AV delay based on the AV interval, and measuring an S1 heart sound characteristic of interest (COI) while utilizing the AV delay in connection with delivering a pacing therapy by the IMD. The one or more processors also perform adjusting the AV delay, repeating the measuring, and adjusting to obtain a collection of S1 heart sound COIs and corresponding AV delays, selecting one of the AV delays, that corresponds to a select one of the S1 heart sound COIs, as a resultant AV delay, and managing the pacing therapy, utilized by the IMD, based on the resultant AV delay.

Abstract: Systems and methods for cardiac pacing during a procedure are disclosed and may include an external pulse generator (EPG) for connecting to a lead. A remote-control module (RCM) wirelessly connected to the EPG may include user inputs to control the EPG. A central processing unit (CPU) with a memory unit for storing code and a processor for executing the code may be included where the CPU is connected to the EPG and RCM. The code may control the EPG in response to user input from the RCM. The CPU may be disposed in the EPG or the RCM, or an interface module (IM) configured to communicate between an otherwise conventional EPG and the RCM. The executable code may perform a continuity test (CT) routine, a capture check (CC) routine, rapid pacing (RP) routine, and/or a back-up pacing (BP) routine, in response to user input from the RCM.

Abstract: An implantable medical device configured to provide for an intracardiac function comprises a body, a sensor arrangement arranged on the body and configured to receive cardiac sense signals, and a processing circuitry operatively connected to the sensor arrangement. The processing circuitry is configured to process cardiac sense signals received using the sensor arrangement to detect atrial events caused by atrial activity based on a comparison of the cardiac sense signals to a sense threshold for a number of cardiac cycles, to evaluate whether a reduction criterion is fulfilled, wherein the reduction criterion is fulfilled if in X1 out of Y1 cardiac cycles no atrial events have been detected, X1 being a natural number equal to or larger than 1 and Y1 being a natural number equal to or larger than X1, and to reduce the sense threshold if said reduction criterion is fulfilled.

Abstract: The present invention discloses an implantable nerve stimulator system. An extracorporeal energy controller of the implantable nerve stimulator system transmits electrical energy to an implantable neurostimulator through radio frequency and communicates with it, including: an input device through which the extracorporeal energy controller receives information; an antenna module that is RF coupling with a stimulator antenna of the implantable neurostimulator; a display device for displaying data, instructions, and the input information; a storage unit storing running programs, input information, and data; and a control unit respectively connected to the input device, the antenna module, and a display device to control the operation of the entire extracorporeal energy controller. The neural stimulation system of the present invention can avoid treatment failure caused by short-term interruption of communication and provide stable power supply to the implantable neurostimulator.

Abstract: Systems and methods which provide a bulkhead anchor configuration in which an anchor body includes flexure finger members and a radial bulkhead operable in cooperation to impart a radial compressive force to a corresponding lead body are described. A first portion of a bulkhead anchor body may comprise a plurality of flexure finger members disposed in a corolla configuration forming an anchor lumen through which a lead body may be inserted. A second portion of the bulkhead anchor body may comprise a radial bulkhead having a flexure profile configured to operatively engage the flexure finger members. A locking mechanism may be used to retain the first and second portions of the bulkhead anchor in their relative positions such that the radial compressive force is maintained upon the lead body indefinitely.

Abstract: Methods, systems, and devices that detect arrhythmic episodes and perform arrhythmia discrimination are described. Such a system includes a leadless pacemaker (LP) that senses a near-field electrogram (NF-EGM), and a non-vascular implantable cardioverter defibrillator (NV-ICD) that senses a far-field electrogram (FF-EGM). The LP determines cardiac activity information based on the NF-EGM and optionally also based on paced cardiac events caused by the LP.

Abstract: A rechargeable implantable neuro stimulator may include a neuro stimulation waveform generator configured to generate neuro stimulation signals. The neurostimulator may further include at least one electrode, at least one rechargeable battery configured to power the neurostimulator, and a coil for receiving power. The coil may be electrically connected to the circuitry for use in recharging the battery using the power received by the coil. The neurostimulator may further include two or more sensors configured for use in determining temperature and a controller.

Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.

Abstract: Disclosed is a skin care device using plasma. The skin care device may include a first plasma generating device; and a main body configured to supply power to the first plasma generating device and to control the first plasma generating device based on an input from a user.

Abstract: Disclosed is a plasma generator. The plasma generator may include a gripping portion including at least one interface unit configured to receive an input from a user; a head portion including a plasma generating portion configured to generate the plasma; a first cartridge configured to detachably couple at a first end of the head portion and generate the plasma over a predetermined region; and a light irradiation portion provided at a second end of the head portion.

Abstract: A treatment pad for a dielectric barrier discharge plasma treatment of a tissue to be treated of an electrically conducting body, which tissue is used as a counter electrode, said treatment pad comprising: a treatment zone, arranged for at least covering the tissue to be treated; a pattern of one or more active areas, integrated in the treatment zone and arranged for generating a dielectric barrier discharge plasma, each said one or more active areas comprising: a first electrode to be coupled to a high voltage power source; a dielectric formed by a coating or foil of a flexible material so that the dielectric shields the first electrode from the tissue to be treated; and a spacer comprising a structured surface of protrusions adjacent a side of the dielectric facing the tissue to be treated; wherein the treatment zone comprises a complementary pattern of non-active areas, such that a complementary part of the tissue to be treated is covered by the said one or more active areas when the treatment pad is reapp

Abstract: Provided is a transcranial magnetic stimulator capable of providing a magnetic stimulation with a required intensity inside a brain even when a current value and a voltage value applied to magnetic stimulation coils in a plurality of resonant circuits are reduced. The transcranial magnetic stimulator includes a plurality of resonant circuits for applying respective pulse currents to a plurality of magnetic stimulation coils to generate variable magnetic fields, and a power source that supplies an electric power to the plurality of resonant circuits. The plurality of resonant circuits are connected in parallel to the power source, and therefore, the plurality of magnetic stimulation coils are also connected in parallel to the power source. The plurality of magnetic stimulation coils are formed in approximately a same shape, and adjacently disposed such that directions of magnetic fluxes generated by the applied pulse currents are matched.

Abstract: Provided is a magnetic stimulation method and a personalized cognitive training method performed alternately, and a device and a system therefor. The magnetic stimulation system comprises: a control unit determining a magnetic field output in accordance with user data comprising a motor threshold and the brain region being stimulated; and a power module connected to a coil generating magnetic field, and supplying power such that the coil generates the determined magnetic field. The control unit can comprise: a motor threshold measurement module measuring the motor threshold of a user by means of a magnetic field changing module; and the magnetic field changing module, using an MRI image of the user, controlling the magnetic field output by adjusting magnetic field-related parameters determined in accordance with the distance to the brain region being stimulated, the state of the user's brain comprising at least one of the brain shape, brain size and head shape of the user, and the measured motor threshold.

Abstract: A method, system, and apparatus for monitoring a magnetic field related to magnetic stimulation may be provided. A system for monitoring a pulsing magnetic field related to magnetic stimulation therapy may include a magnetic stimulation component, a sensor, and a processor. The magnetic stimulation component may be configured to generate the pulsing magnetic field for the magnetic stimulation therapy. The sensor may be configured to generate a signal associated with the pulsing magnetic field. The processor may be configured to estimate a first characteristic associated with a first peak of the signal, estimate a second characteristic associated with a second peak of the signal, and determine a third characteristic of the signal based on the first characteristic and the second characteristic. The processor may be configured to determine whether a failure occurred based on the third characteristic of the signal.

Abstract: Systems and methods are disclosed to provide a modulated stimulation signal to a patient, the modulated stimulation signal including a carrier wave modulated with a biological or natural frequency stimulation signal, to provide the benefit of the biological or natural frequency stimulation signal to the patient without the patient perceiving the biological or natural frequency stimulation signal.

Abstract: A stand-alone appliance can detect a user's face/eyes and provide violet light to the user. The appliance can include a fixture mounted on a platform and at least one motor to move the platform. A directed light source, coupled to a processor, can emit a light signal directed to an adjustable focal point. A camera, coupled to the processor, can detect the user and provide an image of the user's face to the processor. The processor can signal the motor to orient the platform to bring an eye into a center of a frame and adjust the focal point. A distance sensor, coupled to the processor, can estimate a distance between the fixture and the eye to ensure that an appropriate optical energy density is applied to the user. The camera, the directed light source, and/or the distance sensor can be embedded in the fixture.

Abstract: A treatment support system based on the exposure of a user or surface to solar radiation, comprising a server (WS), a plurality of terminals and one or more satellite and/or meteorological atmospheric data sources interfaced with each other, and a processing unit configured to process treatment administration operational information based on satellite and/or meteorological atmospheric data (D3), geolocation data (D2), and user or treated surface specific data (D1).

Abstract: Embodiments of the present disclosure relate to a head-worn apparatus, comprising: a frame adapted to be mounted to a head of a user; a light emitting system positioned within the frame to provide light to an eye of the user; a sound system adapted to provide audio to the user; a haptic system positioned within the frame to provide haptic feedback to the user; and a processor adapted to control the lighting system, audio system and haptic system in a coordinated pattern of light, sound and haptics that causes a mental-health therapeutic stimulus provided to the user, whereby the user experiences an improvement in mental performance based on the coordinated pattern.

Abstract: A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x-ray contrast. The system includes one or more devices which infuse a diseased site with a photoactivatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x-rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.

Abstract: Systems and methods for restructure and stabilization of bones that provide an anti-microbial effect are disclosed herein. A device includes a delivery catheter having an inner void for passing at least one light sensitive liquid, and an inner lumen; an expandable member releasably engaging the distal end of the delivery catheter; at least one channel positioned in the expandable member; and a light conducting fiber sized to pass through the inner lumen of the delivery catheter and into the expandable member, wherein, when the light conducting fiber is in the at least one channel, the light conducting fiber is able to disperse light energy to provide an anti-microbial effect. When the light conducting fiber is in the expandable member, the light conducting fiber is able to disperse the light energy to initiate hardening of the light sensitive liquid within the expandable member to form a photodynamic implant.

Abstract: Methods, systems, and compositions for maintaining functioning drainage blebs to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The methods, systems, and compositions feature the combination of a minimally invasive glaucoma surgery (MIGS) implant or procedure and the application of beta radiation to the bleb. The beta radiation can function to inhibit or reduce the inflammation and/or fibrogenesis that typically occurs after insertion of a MIGS implant and leads to bleb failure. By reducing inflammation and/or fibrogenesis, the MIGS implant and the blebs can remain functioning appropriately.

Abstract: Radiotherapy dose computation techniques including receiving a set of spot locations and corresponding spot weights. The set of spot locations and corresponding spot weights can be interpolated as a function of two coordinate location parameters (x, y) or three coordinate location parameters (x, y, ?). An objective function of the interpolated spot locations and corresponding spot weights can also be computed. Interpolating the spot locations and the corresponding spot weights and computing of the objective function can be performed until the objective function converges to obtain optimized spot dose parameters.

Abstract: Methods of treatment and treatment systems for performing radiomodulatory stereotactic radiosurgery to treat brain disorders in which target neural tissues associated with the brain disorder are sensitized to radiation by administration of a molecular substance and/or non-targeted critical structures are protected from radiation by a molecular substance, in order to treat disorders of brain circuitry. Specific embodiments disclose means for treating pain, obesity and drug addiction.

Abstract: A control circuit accesses patient image content as well as field geometry information regarding a particular radiation treatment platform. The control circuit then generates a predicted three-dimensional dose map for the radiation treatment plan as a function of both the patient image content and the field geometry information.

Abstract: An example method of treating a target using particle beam includes directing the particle beam along a path at least part-way through the target, and controlling an energy of the particle beam while the particle beam is directed along the path so that the particle beam treats at least interior portions of the target that are located along the path. While the particle beam is directed along the path, the particle beam delivers a dose of radiation to the target that exceeds one (1) Gray-per-second for a duration of less than five (5) seconds. A treatment plan may be generated to perform the method.

Abstract: A method for a radiation treatment system includes: a treatment-delivering X-ray source configured to rotate about an isocenter of the radiation treatment system and direct treatment X-rays to a target volume; an imaging X-ray source configured to rotate about the isocenter of the radiation treatment system and direct imaging X-rays to a target region that includes the target volume; and a processor.

Abstract: The disclosed calibration method includes a calibration phantom positioned on an adjustable table on the surface of a mechanical couch, with the phantom's centre at an estimated location for the iso-centre of a radio therapy treatment apparatus. The calibration phantom is then irradiated using the apparatus, and the relative location of the center of the calibration phantom and the iso-centre of the apparatus is determined by analyzing images of the irradiation of the calibration phantom. The calibration phantom is then repositioned by the mechanical couch applying an offset corresponding to the determined relative location of the centre of the calibration phantom and the iso-centre of the apparatus to the calibration phantom. Images of the relocated calibration phantom are obtained, to which the offset has been applied, and the obtained images are processed to set the co-ordinate system of a stereoscopic camera system relative to the iso-centre of the apparatus.