Abstract: Methods and systems for detecting a presence and a concentration of biomarkers relevant to kidney stone formation may be useful in determining a personalized therapeutic approach for a subject. Nuclear Magnetic Resonance (NMR) spectroscopy may be a valuable tool in detecting various biomarkers related to various disease states. A biosample obtained from a subject may be examined using NMR spectroscopy to determine the presence and the concentration of relevant biomarkers.

Abstract: A measuring apparatus implementing an electrode array and an operating method of the measuring apparatus are provided. The measuring apparatus may include an electrode array configured to measure input signals of an analog domain through electrodes arranged in a target point, main signal processors configured to perform signal processing operations including a digital conversion operation of corresponding input signals of the input signals, respectively, and auxiliary signal processors configured to replace at least one of the main signal processors, and perform at least some of the signal processing operations including the digital conversion operation in response to a replacement condition being satisfied.

Abstract: Provided is a method for liquid impedance measurement using a four-electrode device comprising an electrode structure. The method (100) comprises applying a sinusoidal voltage signal across a first outer electrode and a second outer electrode of said electrode structure and performing current and voltage measurements thereof. The method further comprises applying said sinusoidal voltage signal across a reference impedance and performing current and voltage measurements thereof. The method further comprises calculating an outer impedance between said first outer electrode and said second outer electrode based on a subset of the measurements. The method further comprises calculating an inner impedance between said first inner electrode and said second inner electrode a subset of the measurements, wherein the inner impedance represents the liquid impedance. A four-electrode device for performing the method is also provided.

Abstract: The present invention relates to a sensor device, in particular the invention relates to an electronic sensor device formed within a groove of a substrate adapted such that in response to engagement with an analyte a signal response is provided. The invention also relates to a method of forming such a sensor device. The electronic sensor device comprises a substrate comprising at least one groove, said groove including a first face and a second face, said groove having a cross-sectional profile including at least a groove depth In within the substrate and a groove width at a surface of said substrate. Said first face includes a first electrically non-insulating portion and said second face including a second electrically non-insulating portion wherein, within said profile, said first electrically non-insulating portion is electrically separated from said second electrically non-insulating portion.

Abstract: According to one embodiment, a sensor includes a base, first to third detection parts. The base includes first to third base regions. The first detection part includes a first detection element. A first gap is provided between the first base region and the first detection element. The second detection part includes a second detection element. A second gap is provided between the second base region and the second detection element. The third detection part includes a third detection element. The third detection element includes a third resistance member, a third other resistance member, and a third conductive member. The third conductive member is between the third resistance member and the third other resistance member. A third gap is provided between the third base region and the third detection element.

Abstract: An analyte in a liquid sample is detected using a capacitive sensor having electrodes and a sensor surface, and a signal processor. The sample is dried to reduce its liquid content, and capacitive measurements are made after the drying and preferably also before the drying. The sample may include particles, and the analyte is part of or attached to the particles, and the particles provide a major part of the capacitance change compared to absence of particles. In another example the particles are degenerative and form an integral mass upon application of heat, enhancing the extent of capacitance change.

Abstract: An integrated circuit (IC) structure includes a moisture barrier about active circuitry. A capacitor is entirely inside the moisture barrier. The capacitor has a breakdown voltage. A moisture detector is configured to apply an increasing voltage ramp to the capacitor up to a maximum voltage less than the breakdown voltage of the capacitor. In response to determining that a current hump exists in a test current-voltage response curve of the capacitor to the increasing voltage ramp, the detector transmits a signal to the active circuitry to indicate a presence of moisture in the IC structure. The moisture detector is accurate and sensitive to moisture ingress, which provides more time for remedial action. The detector is non-destructive and can be used in a final IC product.

Abstract: A capacitive soil moisture sensor for detecting moisture levels in soil comprises a biodegradable substrate. A capacitive circuit is positioned on the biodegradable substrate. An antenna circuit is configured to communicate capacitance data. A hydrophobic, biodegradable encapsulating material encases at least the capacitive circuit.

Abstract: A device for the detection of wetness in wheel arches of road vehicles includes at least one sensor arrangement including at least one capacitive moisture sensor with two electrodes, electrically insulated with respect to one another, and with at least one evaluation unit, the electrodes, electrically insulated with respect to one another, are arranged on a carrier element, that the electrodes, electrically insulated with respect to one another, are formed by two detection sections arranged parallel to one another, and that the detection sections, when used as intended, are aligned respectively in a rising manner in their longitudinal extent. The device also relates to a road vehicle for the detection of wetness, with at least one wheel arch, with which provision is made according to the invention that the wheel arch is delimited by a wheel-housing shell, at which a device according to the invention is arranged.

Abstract: The disclosure provides a gas permeable electrode and method for making the electrode to create diffusion pathways (or pores) in the metal electrode in a manner that is not destructive to delicate or soft sensing material. A first polymer, which is gas-permeable, is applied as a continuous coating over a surface of the sensing material. A second polymer that is immiscible with the first polymer is applied over a surface of the first polymer (e.g., spray-dry deposition of the second polymer) to form a micro-pattern or a polymeric template. The incompatibility/immiscibility between the first polymer and the second polymer leads to segregation of the second polymer into a pattern of discontinuous bumps, dots, islands or blobs on top of the first polymer. The porous electrode comprises at least one layer of an electrically conductive metal that is deposited over the first and second polymers.

Abstract: Bearing impedance in a rotary electric machine may be estimated by isolating bearings from a frame with a dielectric pad, determining a pad capacitance, supporting the rotor by an inner race of the bearing, operating the rotary electric machine, measuring bearing inner race and outer race voltages, measuring current bypassing the dielectric pad, and estimating bearing capacitance and resistance based upon the pad capacitance, the measured and the measured current.

Abstract: A measurement system including a sensor and a measurement device including an insertion port for the sensor, wherein the measurement device measures a measurement target component at the sensor and includes plural terminals contacting the sensor, and the terminals slide on a contact surface of the sensor, the contact surface has a first electrode group on a rear end side and a second electrode group on a distal end side, the plural terminals receive static frictional forces from the contact surface and include a first terminal group contacting the first electrode group on a side closer to the insertion port than a side on which a second terminal group contacting the second electrode group, and a sum of static frictional forces that the first terminal group receives from the contact surface is smaller than a sum of static frictional forces that the second terminal group receives from the contact surface.

Abstract: A gas sensor system includes a first pipe through which a specimen atmosphere is conveyed; a second pipe through which humidified air is conveyed, the humidified air being hotter and more humid than the specimen atmosphere, the humidified air having a lower water vapor pressure than a saturation water vapor pressure; a mixing device mixing the specimen atmosphere and the humidified air so that a water vapor pressure of mixed air of the specimen atmosphere and the humidified air is less than a saturation water vapor pressure; a third pipe connected with the mixing device; a cooling device cooling the mixed air conveyed through the third pipe so that the water vapor pressure of the mixed air becomes the saturation water vapor pressure; and a chemical sensor device including a sensor surface to which the mixed air cooled by the cooling device is supplied.

Abstract: A life-form sensor and a method of detecting a life-form and disinfecting the sensor is provided. The sensor includes a matrix member made from a composite material having needle-like particles, electrically conductive platelets and a spacer material. A pair of electrodes are electrically coupled to opposing ends of the matrix. A heating device is arranged in thermal communication with the matrix member. A controller is operably coupled to the sensing device, the heating device, and the electrode, the controller being configured to receive a signal from the pair of electrodes and to polarize the matrix member and activate the heating device to a predetermined temperature range in response to placing a sample in the specimen container to simultaneously detect the presence of a target life-form and to disinfect the matrix member.

Abstract: A sensor for a flexible sensor assembly includes a drive coil, a first set of sensing coils, a second set of sensing coils, and a configuration for sensing for discontinuities in a structure desired to be sensed. A method of operating the sensor can include positioning the sensor proximate to the structure, energizing the drive coil, and sensing eddy currents with the sensing coils.

Abstract: Provided are an elastic wave radar detection device and method. The device includes a vibration excitation device, a first sensor, a second sensor, and a controller. The first sensor is arranged on the vibration excitation device, and the second sensor is arranged on a detected object. The first sensor is used to collect vibration excitation information, namely, an incident signal, and the second sensor is used to collect information of the detected object, namely, a vibration signal. Both the first sensor and the second sensor are connected to the controller. The elastic wave radar detection device and method provided by the present disclosure can receive vibration excitation information and introduce a standard incident signal, so as to achieve the uniformity of signals and improve the detection accuracy.

Abstract: Generally, in a non-destructive test application, a compressed representation of an acoustic echo signal acquired by a non-destructive test (NDT) probe assembly can be received, such as via a network. The compressed representation can include data indicative of changes in phase values of the acoustic echo signal. Using the compressed representation, a time-domain representation of an instantaneous phase signal can be constructed from the compressed representation. The constructed instantaneous phase signal can be used in constructing at least one of an uncompressed acoustic echo signal representation or an image. As an illustration, amplitude values of sampled acoustic echo signals can be suppressed in the compressed representation, reducing data volume associated with transmitting a representation of the acquired acoustic echo signal.

Abstract: The present disclosure provides systems and methods which facilitate the prediction of an estimated time in which one or more fluids will optimally be diffused into a biological specimen, e.g., a tissue sample derived from a human subject. In some embodiments, the present disclosure provides systems and methods which facilitate the prediction of an estimated time until a biological specimen will optimally be fixed with one or more fixatives. In other embodiments, the prediction of a future time at which the biological specimen will be optimally fixed is based on time-of-flight data acquired at a particular point in time during the fixation of the biological specimen that has been deemed sufficiently accurate to predict the time at which the biological specimen will be optimally diffused with fixative.

Abstract: The present disclosure belongs to the field of photoacoustic signal detection, and specifically relates to a quantum-enhanced all-optical photoacoustic signal detection device and method. The problem of low sensitivity of photoacoustic signals based on interference measurement is solved, and high-sensitivity detection of photoacoustic signals generated by living organisms including human bodies can be achieved. A degenerate optical parametric oscillator based on a first-type phase matching crystals is used for preparing a vacuum squeezed state light field, a coherent control technology is used for locking the squeezed angle to obtain the quadrature phase vacuum squeezed state, the prepared quadrature phase vacuum squeezed state light field is injected into the vacuum channel of a Michelson interferometer, and a balanced homodyne detection mode is used for achieving detection of the quantum-enhanced photoacoustic signals.

Abstract: A method for determining whether a defect is present in a ceramic component includes determining a temperature difference between a first temperature and a second temperature based on an intended use of the ceramic component, bringing the ceramic component to a first temperature, after bringing the ceramic component to the first temperature, bringing the ceramic component to a second temperature, performing a resonance ultrasound spectroscopy on the ceramic component after bringing the ceramic component to the second temperature to produce an ultrasound spectrum of the ceramic component, comparing the ultrasound spectrum with a reference spectrum to determine a degree of similarity between the ultrasound spectrum and the reference spectrum, and determining from the degree of similarity whether the defect is present in the ceramic component.

Abstract: Embodiments relate to systems and methods for fluidization in industrial hygiene applications. The method includes collecting air samples of contaminants onto the surface of fluidized activated carbon particulate as opposed to fixed-bed particulate. The adsorbates include toluene (a cyclic compound) and n-hexane (an open-chain compound). The obtained results are analyzed and discussed in terms of breakthrough times. The input parameters are the initial concentration of toluene or n-hexane in the air feed stream and the amount of the sorbent used. The feed flow rate is at 2 liters/min, and the temperature and humidity are kept constant at their prevailing laboratory conditions, i.e., 22±2° C. and 34±2% RH, respectively.

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.

Abstract: An ion chromatography analysis system includes a system monitoring part being configured to detect an abnormality, to determine, based on a fluctuation rate in a certain time of the predetermined state of a most recent of the monitor value, whether the fluctuation is a short-term fluctuation that occurs in a short term or a long-term fluctuation that occurs in a long term, and to identify a cause of the abnormality by using whether the fluctuation is the short-term fluctuation or the long-term fluctuation.

Abstract: A method, for use in a mass spectrometer or computer software, and computer readable medium, for acquiring mass spectral data; comprising acquiring mass spectral data for a sample; selecting a relevant retention time window for presence of possible compounds of interest; using positively identified analytes from a sample run to convert retention time into retention index; determining a retention index range for said relevant retention time window; using the acquired spectral data in said relevant retention time window to perform a spectral library search to identify possible compounds; selecting a subset of possible compounds based on at least one of their retention index values and spectral library search scores; performing a regression analysis, between the spectral data within the retention time window and the library spectrum of at least one of the subset of possible compounds; and reporting the regression coefficients as representative of the concentrations or chromatograms of said possible compounds.

Abstract: Provided is a method capable of shortening the time required for analysis and capable of analyzing various substances produced by microorganisms. A method for analyzing a metabolite of a microorganism according to the present invention includes: a step of supplying a mobile phase including carbon dioxide in a liquid state, a subcritical state, or a supercritical state to a container in which a microorganism cultured in a medium is contained together with the medium, to move a component of a metabolite of the microorganism present in the microorganism and the medium to the mobile phase; a step of introducing a mobile phase to which a component of the metabolite has moved into a column; and a step of performing mass spectrometry on a component of the metabolite contained in the mobile phase that has passed through the column.

Abstract: A chemical sensor system includes a first chemical sensor, a second chemical sensor unit, and a first sample atmosphere tank located between the first chemical sensor and the second chemical sensor unit, and includes an air supply mechanism that executes a first operation of supplying a sample atmosphere from the first chemical sensor to the first sample atmosphere tank, a second operation of supplying the sample atmosphere from the first sample atmosphere tank to the second chemical sensor unit, and a third operation of discharging the sample atmosphere in the first sample atmosphere tank.

Abstract: A system, device, and method for sensing air quality with a sensor platform is disclosed. The method includes (i) directing a set of mobile sensors to a coarse region wherein the coarse region has coarse size based on variance of prior air quality measurements taken at locations within a vicinity of the coarse region, and (ii) directing the set of mobile sensors to a fine region wherein the fine region has a fine size based on variance of prior air quality measurements taken at locations within a vicinity of the fine region. The variance of air quality measurements associated with the fine region is greater than a variance of air quality measurements associated with the coarse region.

Abstract: A first synthesized characteristic value calculated based on a first blending ratio of constituent materials contained in a first composite material and on a first characteristic value corresponding to the constituent materials contained in the first composite material, as well as first blending information of the constituent materials contained in the first composite material are used as input parameters (explanatory variables) for an approximate function to estimate a value of physical quantity (objective variable) for the first composite material.

Abstract: Apparatus, systems and methods are provided that leverage plugin modules supplemented by machine learning to create a robust and adaptable forensic investigation tool that obtains data from one or more data sources, separates the data into smaller units of data (e.g., deconstructs the data into its smallest logical data items/fields) determines common data types within the smaller units, creates “edges” that match data from the one or more data sources with data already in the system, then determines potentially overlapping clusters of information to identify potential connections between investigations and displays the information on a display in link form or grid form.

Abstract: A method and device for measuring living cells are provided. A device includes a culture vessel in which a living cell is cultured; and a multi-electrode array (MEA) including first electrodes arranged with a pattern and configured to conductively receive an electrical signal generated by the living cell and conductively transmit an electrical signal to the living cell through the first electrodes, wherein the culture vessel is mateable with the MEA, and configured to, when mated with the MEA, conductively transmit an electrical signal generated by the living cell to the first electrodes or conductively transmit an electrical signal to the living cell via the first electrodes through a surface mated with the MEA.

Abstract: Provided herein are methods of employing pharmacodynamics regimens to maximize effectiveness of voclosporin in treatment of proteinuric kidney diseases while minimizing undesirable side effects, such as but not limited to calcineurin inhibitor nephrotoxicity. Also provided are methods of assessments of renal functions and/or conditions, and corresponding protocols to modify, stop, restore and/or re-initiate voclosporin dosing and administrations to maximize effectiveness of voclosporin in treatment of proteinuric kidney diseases while minimizing undesirable side effects.

Abstract: A new cell line and an antibody for determining the activity of botulinum toxin are disclosed. Also disclosed is a method of determining the activity of botulinum toxin using the cell line and/or the antibody.

Abstract: Collectively, rare diseases affect approximately 350 million people worldwide, of which half are diagnosed in childhood. Even though more than 80% of rare diseases are genetic in origin and begin in utero, drug target discovery has historically been stymied due to difficulties in obtaining fetal, neonatal, and pediatric tissues for genetic study and drug discovery. Disease modeling with patient-specific hiPSCs is an ideal platform for both rapid identification and experimental validation of early life disease mechanisms. This invention combines high content genomic assays, phenotypic measurements, and machine learning (Artificial Intelligence/Machine Learning) with hiPSC disease models to identify DNA mutations causing early life diseases.

Abstract: The present invention relates generally to the field of biomarkers. The biomarker identified in the present invention is phenol. For example, the present invention relates to the use of phenol as a biomarker for detecting and/or quantifying mood disorder, improvements of the mood disorder status and/or the resulting emotional reaction of a subject. Embodiments of the resent invention relate to a method of detecting and/or quantifying mood disorder, improvements of the mood disorder status and/or the resulting emotional reaction of a subject, comprising determining the level of phenol in a body sample obtained from a subject to be tested, and comparing the subject's phenol level to a predetermined reference value, wherein a decreased phenol level in the sample compared to the predetermined reference value indicates an improvement of the mood disorder status and/or the resulting emotional reaction of the subject.

Abstract: The present invention relates generally to the field of biomarkers. The biomarker identified in the present invention is 2-methylbutyrate. For example, the present invention relates to the use of 2-methylbutyrate as a biomarker for detecting and/or quantifying mood disorder and improvements of the mood disorder status and/or the resulting emotional reaction of a subject. Embodiments of the resent invention relate to a method of detecting and/or quantifying mood disorders, improvements of the mood disorder status and/or the resulting emotional reaction of a subject, comprising determining the level of 2-methylbutyrate in a body sample obtained from a subject to be tested, and comparing the subject's 2-methylbutyrate level to a predetermined reference value, wherein an increased 2-methylbutyrate level in the sample compared to the predetermined reference value indicates an improvement of the mood disorder status and/or the resulting emotional reaction of the subject.

Abstract: The present disclosure describes a system and methods for positioning a configured number of biomaterials on a surface. The method disclosed includes the formation of a membrane mask structure including a configured number of nanopores. The nanopores are generally sized to be the same size as, or slightly larger than a single target biomaterial. The masking membrane is then adhered to a substrate. The substrate may include a raw substrate, or may be functionalized for the purpose of binding biomaterials with greater attraction. A solution including the target biomaterials is then exposed to the masking membrane. One biomaterial is able to adhere to the substrate through each nanopore. The solution is rinsed from the membrane surface leaving only the biomaterial that has adhered to the substrate with a relatively strong binding force. The masking membrane may then either remain or may be removed.

Abstract: Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.

Abstract: A biosensor with a detection transistor of a metal-semiconductor field-effect (MESFET) type, for detecting a target substance. The detection transistor has an isolating substrate, a source electrode, a drain electrode, a first gate electrode, a channel for transmitting a drain-source current between the source electrode and the drain electrode, the channel being made of an oxide semiconductor, arranged on the isolating substrate and having the source electrode and the drain electrode arranged thereon, a sensitive substrate connected to the first gate electrode and including functionalization species for bonding the target substance, such that the first gate electrode connected with said substrate is sensitive to the target substance, and a second gate electrode arranged on the isolating substrate, physically separated from the first gate electrode by the channel, positioned opposite to the first gate electrode and aimed to modulate the drain-source current of the channel.

Abstract: A lateral flow assay device that contains multiple test strips, allows multiple tests on a single fluid sample, and displays and transmits the test results to external monitors. The device receives a fluid sample and distributes it to multiple, independent test strips by capillary action. Each test strip has a conjugate pad, test line, and control line, that are designed to detect the presence of a specific analyte. Once the test is complete, photosensitive detectors convert the test results into electrical signals and transmit them to a motherboard. The motherboard then analyzes the test results to format appropriate messages, and transmits the messages to external monitors as well as to the device's own display screen.

Abstract: Disclosed is a system for rapid analysis of a capillary blood sample from a subject, intended for detecting the presence of at least one analyte in the capillary blood sample. The rapid analysis system includes an analysis module in which is incorporated at least one immunochromatographic strip. The analysis module includes: a pricking member, suitable for generating a drop of capillary blood; and a collecting member, including a fixed duct, suitable for capillary blood to flow therethrough. The duct has an inlet suitable for collecting the drop of capillary blood, and an outlet, arranged opposite the deposition area and suitable for depositing the drop of capillary blood onto the deposition area, and a container, separate from/independent of the analysis module, in which is packed a buffer solution suitable for implementing the immunochromatographic technique.

Abstract: A detection system and method for the migrating cell is provided. The system is configured to detect a migrating cell combined with an immunomagnetic bead. The system includes a platform, a microchannel, a magnetic field source, a coherent light source and an optical sensing module. The microchannel is configured to allow the migrating cell to flow in it along a flow direction. The magnetic field source is configured to provide magnetic force to the migrating cell combined with the immunomagnetic bead. The magnetic force includes at least one magnetic force component and the magnetic force component is opposite to the flow direction of the microchannel. The coherent light source is configured to provide the microchannel with the coherent light. The optical sensing module is configured to receive the interference light caused by the coherent light being reflected by the sample inside the microchannel.

Abstract: The present invention provides a lateral flow device for detecting lipoteichoic acid (LT A) as a Gram-positive bacteria identifier in a milk sample of an animal.

Abstract: The invention pertains to improved treatment methods using DMDS, in particular cladribine, for the treatment of autoimmune diseases, in particular multiple sclerosis, and biomarkers, in particular immune cell subtypes, for predicting and/or optimising said treatment methods. The methods described rely on the use of immune cell subtypes, in particular T cells, B cells, NK cells subtypes and their ratios as present in blood samples from the patients for predicting and/or optimising the use of cladribine in the treatment of multiple sclerosis.

Abstract: Methods and devices for detecting and diagnosing the etiological agents associated with Canine Infectious Respiratory Disease Complex in animals, such as kennel cough, are disclosed herein.

Abstract: The invention provided herein a pharmaceutical process used for an extraction of proteins from pancreatic sample and estimation of the extracted proteins. Moreover, the invention provides a use of suitable is selected from citrate-phosphate buffer and bicarbonate buffer capable to extract proteins from pancreatic sample. The invention further provides an analytical method to perform estimation of extracted proteins. This process provides an improved extraction method to quantify protein present in the pancreatic sample.

Abstract: A microfluidic device capable of performing nondisruptive fluid manipulations in a living host is provided. The microfluidic device may include a combinatorial multiplexer for better scaling of multiple time points and biological signal measurements. The collected samples may be transported, stored and analyzed ex vivo for analytical ease and flexibility, e.g., by a sample analysis assay chip. The microfluidics device may include structure for maintaining fluid equilibrium within the host during the sampling to avoid damage to the host or to the implant.

Abstract: Methods are provided for assaying neoplastic cells and/or neoplasia-related cells. Aspects of the methods involve detecting heterogeneity, per cell programmed-death ligand 1 (PD-L1) expression, and/or proliferation of neoplasia and/or neoplasia-related cells. Aspects of the methods include cytometrically assaying a labeled cell suspension to quantify per cell heterogeneity, per cell PD-L1 expression, proliferation, and/or other parameters to detect whether a neoplastic cell is present in the neoplasia sample. Aspects of the provided methods also include treating a subject based on the outcome of such an assay. In addition, kits that find use in practicing the subject methods are also provided.

Abstract: Described herein is a flow cytometry platform for the detection of glycosylated proteins in a clinical sample, along with the use of a flow cytometry platform for early disease diagnoses, for example, hepatocellular carcinoma (HCC). The use of the flow cytometry platform described herein allows for multiplexing and quantification of two or more biomarkers associated with the disease, for example, alpha-feto protein (AFP), alfa-feto protein-L3 (AFP-L3), or alpha-L-fucosidase (AFU) for HCC patients.

Abstract: The invention relates to methods and uses of a panel of biomarkers in a body fluid sample for diagnosing and/or monitoring lung cancer, in particular early stage lung cancer. The biomarkers include particular histone modifications present on cell free nucleosomes, in combination with Carcinoembryonic Antigen (CEA).

Abstract: The present disclosure relates generally an immunoassay platform that utilizes a bead-based system to detect the presence or absence of antibodies in a test sample. The disclosed platform relates to methods and kits and can be used to detect the presence, absence, or exposure to Borrelia miyamotoi or Hepatitis D virus (HDV), or other pathogens or microbes of interest in a subject.