Abstract: Styryl compounds useful for preparing biological detections probes, and the use of the Styryl compounds for the detection, discrimination and quantification of biological targets.

Abstract: The technology subject of the present application generally concerns methods for in vivo or in vitro detection of cancer cells utilizing selective particle-uptake in cancer samples.

Abstract: The present invention relates to a method for the identification a sequence of monomer building blocks of a biological or synthetic heteropolymer. The invention also relates to the use of a nanopore for identifying a sequence of monomer building blocks of a biological or synthetic heteropolymer. The invention further relates to a computer-implemented method, computer program code, and data processing system for identifying a sequence of monomer building blocks of a biological or synthetic heteropolymer.

Abstract: Provided herein are methods, chemical library and simulation system for performing in situ patterned chemistry. Methods, systems and assays comprising the use of the synthesized chemical libraries, which increase explored protein space in a knowledge-based manner, are also provided for characterizing antibody-target interactions including: identifying target proteins of antibodies, characterizing antibody-binding regions in target proteins, identifying linear and structural epitopes in target proteins, and determining the propensity of antibody binding to target proteins.

Abstract: Provided is a non-transitory computer-readable medium storing a program for causing a computer to execute the steps including a step of subjecting a sample containing microorganisms to mass spectrometry to obtain a mass spectrum, a step of reading a mass-to-charge ratio m/z of a peak derived from a marker protein from the mass spectrum, and an identification step of identifying which bacteria of serovar of Salmonella genus bacteria the microorganisms contained in the sample contain, based on the mass-to-charge ratio m/z, wherein at least one of two types of ribosomal proteins S8 and Peptidylpropyl isomerase is used as the marker protein.

Abstract: The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands.

Abstract: Herein is reported the use of a binding assay of a bivalent, bispecific antibody that has the smaller kD value (dissociation constant) for the interaction with its antigen for the immobilization of the bivalent, bispecific antibody to a solid surface for the determination of the biological activity of the bivalent, bispecific antibody.

Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.

Abstract: This disclosure relates to methods for detection and measurement of anti-drug antibodies (ADAs) against Factor XI and/or Factor XIa therapeutic antibodies, e.g., in a subject being treated with said Factor XI and/or Factor XIa therapeutic antibodies.

Abstract: Therapeutics and methods of diagnosing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in a patient comprising obtaining a sample from the patient, determining a level of a signaling lymphocytic activation molecule 1 (SLAMF1) in the sample from the patient, and diagnosing the patient with NAFLD when the level of the SLAMF1 is at least an elevated threshold level for the SLAMF1. Therapeutics and methods of treating non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in a patient in need of treatment comprising administering a pharmaceutically effective dose of a therapeutic, wherein the therapeutic includes a signaling lymphocytic activation molecule 1 (SLAMF1) antagonist.

Abstract: This invention includes methods for assessing and treating risk of cardiovascular disease (CVD) in a subject with an inflammatory disease, for example rheumatoid arthritis (RA). Provided are methods for assessing risk, for recommending therapy, for prognosis and monitoring, and for treatment, which are advantageously accurate for CVD in RA. The methods include measuring quantitative data for biomarkers, calculating a CVD risk score for a subject using training data, and validating the CVD risk score with a set of validation clinical data.

Abstract: The present disclosure relates in part to a blood-based method for the detection of a proteinopathy in a subject including, but not limited to, Alzheimer's disease (AD), mild cognitive impairment (MCI), and preeclampsia (PE), utilizing autophagy-deficient trophoblast (ADT) cells to sequester protein aggregates from the serum of said subject, and permit detection thereof. The present disclosure further relates to methods of treating, preventing, and/or ameliorating a proteinopathy in a subject by the administration of trehalose, a salt, solvate, stereoisomer, derivative, prodrug and or any mixture thereof.

Abstract: The purpose of the present technology is to provide a technique for accurately determining cognitive impairment, cognitive decline, or risk of any of them. The present technology provides a determination supporting information generating method, comprising: an index value calculating step of calculating, based on amounts of two or more biomarkers contained in a biological sample derived from a human, (I) a first index value indicating the presence or absence of cognitive impairment or cognitive decline in the human and (II) a second index value indicating the degree of progression of cognitive impairment or cognitive decline in the human; and a supporting information generating step of generating information that supports determination of cognitive impairment, cognitive decline, or risk of any of them, based on the first index value and the second index value.

Abstract: Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind recognitions motifs comprising a LMVGG [SEQ ID NO: 3] sequence. Also provided are methods (e.g., orthogonal transpeptidation and diagnostics methods) for using such sortases.

Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

Abstract: A method for estimating a cause of coagulation time prolongation includes 1) detecting a coagulation reaction end point Pe in a coagulation reaction curve of a subject blood specimen having a prolonged coagulation time; 2) calculating T(X), wherein T(X) represents a measurement point or time at which the coagulation reaction curve reaches X % of Pe, and X is a variable of greater than 0 and equal to or less than 100; and 3) estimating a cause of coagulation time prolongation of the subject blood specimen based on a form of T(X).

Abstract: The disclosure provides a method of measuring the relative RBP-binding affinity of a liposome in a sample. In some aspects, the method comprises contacting the sample with a modified RBP associated with an immobilized surface, wherein an exterior surface of the liposome comprises a retinoid or a fat-soluble vitamin, and wherein the modified RBP binds the retinoid or the fat-soluble vitamin.

Abstract: The present disclosure provides systems, devices, and methods for processing a sample. Systems for processing a sample may include one or more of input modules, processing modules, thermal modules, detection modules, or computer processors. Devices for processing a sample may include cartridges, chips, fluidic pathways, or electronic circuitry. Methods for processing a sample may include one or more of generation of sampling instructions or processing instructions, sample collection, analyte detection, sample analysis, and results reporting.

Abstract: A sample analysis apparatus includes a first chamber that performs a first heating process for heating a small sample and a second chamber including a second chamber housing in which a second heating process for heating a wafer sample is performed. The first chamber includes a first chamber housing in which the first heating process is performed, a first support that supports the small sample, a first heating device that heats the small sample, an accommodation housing in which the small sample is accommodated, a sample tray arranged in the accommodation space, sample container configured to store the small sample, and a transfer module configured to transfer the sample container and the small sample from the accommodation housing to the first chamber.

Abstract: A waste liquid suction mechanism, a reaction disc, and a sample analyzer are provided. The waste liquid suction mechanism includes: a driving assembly; a lifting assembly, performing lifting movement under the action of the driving assembly, where a guide block is disposed on the lifting assembly, and stroke positions of the lifting assembly include a trigger position and a release position located below the trigger position; a suction needle assembly, disposed on the lifting assembly and performing lifting movement along with the lifting assembly, and including a suction needle configured to suck waste liquid; and a collection assembly, disposed below the suction needle assembly, and including a rotary stopper configured to block or release the suction needle.

Abstract: A conveyor assembly for transporting a carrier coupled to a receptacle to a processing station located within a housing of an instrument. The conveyor assembly includes a spur conveyor subassembly and a buffer conveyor subassembly for transporting the carrier from a host conveyor assembly to the spur conveyor subassembly. The spur conveyor subassembly includes (i) a rotatable diverter having at least one recess for receiving and moving the carrier between the buffer conveyor subassembly and the spur conveyor subassembly and (ii) a gripper configured to grasp the carrier and move it from the diverter to the processing position located within the housing of the instrument.

Abstract: Disclosed is a high-precision vehicle velocity calculation method. The method includes: calculating a tire slip rate at the current moment, determining whether the slip rate is smaller than a threshold value, if so, continuing to correct a tire radius and acceleration; establishing a relational expression for tire angular acceleration, an acceleration measured value, an acceleration offset and a tire radius at the current moment; building a system prediction model; building a measurement system model; substituting the system prediction model and the measurement system model into a Kalman filter prediction model, to acquire a corrected value of the tire radius at the current moment and a corrected value of the acceleration offset at the current moment; and calculating a vehicle velocity at the current moment based on the corrected value of the tire radius at the current moment and the corrected value of the acceleration offset at the current moment.

Abstract: A system comprises a pressure air data system comprising non-optical air data sensors that interrogate a region of interest outside of a vehicle to determine a first set of air data measurements comprising a first static air pressure. The system also includes an optical air data system comprising optical air data sensors that interrogate the region of interest to determine a second set of air data measurements comprising a second static air pressure. The second static air pressure is determined using conversion coefficients. A processor receives and processes the first static air pressure; receives and processes the second static air pressure; dynamically recalibrates the conversion coefficients by computing a correction factor; sends the correction factor to the optical air data system to update the second static air pressure; and outputs an optimized static air pressure based on the first static air pressure and the updated second static air pressure.

Abstract: A sensor assembly. The sensor assembly has a substrate, a seismic mass, and a functional layer arranged between the substrate and the seismic mass. The seismic mass is connected to the substrate in such a way that the seismic mass can be deflected at least along a first direction running perpendicular to the substrate. Within the functional layer and between the seismic mass and the substrate, at least one stop is formed that is spring-loaded and can be deflected along the first direction.

Abstract: An acceleration sensor system, includes: an acceleration sensor including an acceleration detection part and an offset detection part; and a processing part configured to process respective outputs of the acceleration detection part and the offset detection part, wherein the acceleration detection part includes a first electrode, a second electrode, and a third electrode provided between the first electrode and the second electrode, wherein one of each of the first and second electrodes and the third electrode is a fixed electrode while the other of each of the first and second electrodes and the third electrode is a movable electrode, wherein the offset detection part includes a fourth electrode, a fifth electrode, and a sixth electrode provided between the fourth electrode and the fifth electrode, and wherein the fourth electrode, the fifth electrode, and the sixth electrode are fixed electrodes.

Abstract: A method comprises receiving a signal from a piezoelectric device and receiving a measurement of a temperature of the piezoelectric device. The method further comprises reading a first parameter from a memory, in which the first parameter depends on the temperature and relates the signal to an acceleration value and reading a second parameter from the memory, in which the second parameter represents a degree of drift of the piezoelectric device at the temperature. The method further comprises determining an acceleration of the piezoelectric device based on the signal, the first parameter, and the second parameter.

Abstract: The purpose of the present invention is to provide a speed measurement device with which it is possible to accurately identify the highest travel speed of a work machine using the result of measurement by an acceleration sensor. The speed measurement device according to the present invention: detects, from within a record of the travel acceleration of a work machine, a change point at which the work machine transitions from an accelerating state to a steady travel state; and identifies the highest travel speed from a record of the travel speed in a period later than the change point.

Abstract: Exemplary embodiments of the present disclosure can include, for example, an atomic force microscopy (AFM) system, including a cantilever(s), an optical pickup unit(s) (OPU(s)) including a laser positioned over the cantilever(s), and a power source providing noise with a noise level that is below 300 Picometers. The noise level of the power source can be below 200 Picometers. A digitizing arrangement can be included which can be associated with the OPU. The digitizing arrangement(s) can have a bandwidth of about 2 MHZ. The OPU(s) can have a detection bandwidth of at least 80 MHZ. The exemplary apparatus can be combined with a chemical protocol and statistical signal processing and image analysis procedures to map DNA at high speed and accuracy.

Abstract: An engaging device in a Mass-Interconnect, which provides an apparatus and method to change test adapters for testing applications. An engaging device of a Mass-Interconnect includes an interchangeable test adapter (ITA) and a locking mechanism. The locking mechanism includes a plunger having a plunger head at a first end thereof, a leaflet insert disposed over the plunger, a sleeve disposed over the leaflet insert, an over-dead-center (ODC) link connected to the plunger at a second end thereof opposite to the first end, and a rotatable handle connected to the ODC link. The plunger, the leaflet insert, and the sleeve of the locking mechanism engage or disengage the ITA when a user rotates the rotatable handle.

Abstract: A needle block for easy adjustment of a tip length of a needle unit, includes: an upper guide plate having a first insertion hole on one side; a lower guide plate separated from the upper guide plate below the upper guide plate and having a second insertion hole at a position corresponding to the first insertion hole; a gap plate interposed between the upper guide plate and the lower guide plate and maintaining the gap between the upper guide plate and the lower guide plate; needle units installed at preset intervals and inserted into the first and second insertion holes with upper and lower end portions supported on one side of the inner surface of the upper guide plate and one side of the inner surface of the lower guide plate, respectively; a gap adjustment member; and a coupling member coupled to one side of the gap plate.

Abstract: A probe card, a method for designing the probe card, a method for producing a tested semiconductor device, a method for testing an unpackaged semiconductor by the probe card, a device under test, and a probe system are provided. The probe card includes a wiring substrate, a connection carrier board, and a probe device. At least two probes form a differential pair electrically connected to a loopback line of the connection carrier board to form a test signal loopback path. The probe device has a probe device impedance on the test signal loopback path. The loopback line has a loopback line impedance on the test signal loopback path. A difference between the probe device impedance on the test signal loopback path and the loopback line impedance on the test signal loopback path is in an impedance range.

Abstract: A capacitive voltage sensor assembly includes a first electrode extending along a longitudinal axis, a tubular section surrounding a portion of the first electrode and positioned radially outward from the longitudinal axis and the first electrode, the tubular section including an insulating layer, an inner conductive layer, and an outer conductive layer, and a mass of dielectric insulating material at least partially enclosing the first electrode and the tubular section. The mass of dielectric insulating material fills through openings formed in the tubular section.

Abstract: Provided is a current measurement module including: a conductor which has two main body portions and two current paths disposed between the two main body portions and extending in parallel with a gap; two magnetic field sensing elements which each have a magnetosensitive surface disposed such that magnetic fields generated by current flowing through the two current paths penetrate the magnetosensitive surface in directions opposite to each other; and a substrate which supports the two magnetic field sensing elements and is attached to the conductor, the two main body portions each have a slit which extends from the gap and is narrower than the gap, and the substrate is inserted into the slit and the gap.

Abstract: A voltage matching circuit receives a first voltage received by a connector, and outputs a second voltage. The second voltage is equal to the first voltage, if the first voltage is less than a threshold voltage. The second voltage is equal to the first voltage divided by a first factor, if the first voltage is greater than or equal to the threshold voltage.

Abstract: A voltage management device according to the present disclosure includes a communication unit that obtains, for each of sections in a power system, a measurement value of a voltage measured by a smart meter connected to that section, where the sections are generated by segmentation between monitoring points, and a voltage estimation unit that estimates, for each of the sections, a voltage drop quantity and a voltage rise quantity in that section using the measurement value.

Abstract: Disclosed are a tunable coupler, a calibrating method and device for the tunable coupler, a quantum controlling system, and a readable storage medium. The calibrating method does not directly characterize the frequency of the tunable coupler. Instead, it biases magnetic flux of the tunable coupler (i.e., biasing voltage and pulse voltage) so as to complete calibration of the tunable coupler and obtain a work point of the tunable coupler where the effective coupling of the tunable coupler is off.

Abstract: A test apparatus includes a test chamber or open area test site configured to receive a device under test and a test fixture located in the test chamber. The test fixture includes at least one fixture antenna. The test apparatus further includes a positioner located within the test chamber. The positioner is configured to support the device under test and rotate the device under test at least 180 degrees about a vertical axis of the test chamber.

Abstract: Methods, systems, and devices for hardware noise filtering are described. A wearable device may emit light from a set of light emitting elements (e.g., light emitting diodes (LEDs)) based on a known input signal. The wearable device may measure an output signal at a set of photodetectors. The output signal may be generated by passing the light emitted from the set of light emitting elements into a material in contact with the wearable device. The wearable device may compare the known input signal to the output signal and may determine a hardware noise component of the output signal based on a known environmental noise component of the output signal and the comparison. The wearable device may store the hardware noise component for filtering hardware noise from sensor measurements.

Abstract: A system of the present disclosure has a host testing device having a first wireless transceiver and having host testing device logic configured to transmit a test command via the first wireless transceiver. Additionally, the system has a remote testing device coupled to a system component. The remote testing device has a second wireless transceiver and remote testing device logic that receives the test command from the host testing device and executes the test command on the system component.

Abstract: In one embodiment, a method includes receiving at a thermal modeling module, data from a Power Sourcing Equipment device (PSE) for cables extending from the PSE to Powered Devices (PDs), the cables configured to transmit power and data from the PSE to the PDs, calculating at the thermal modeling module, thermal characteristics for the cables based on the data, and identifying a thermal rise above a specified threshold at one of the cables. The data comprises real-time electrical data for the cables. An apparatus and logic are also disclosed herein.

Abstract: The present disclosure relates to systems and methods for calculating noise distributions in an electric power system. In one embodiment, a system to calculate a noise distribution in an electric power system may comprise a measurement subsystem to obtain a plurality of raw measurements of a parameter in the electric power system. A noise distribution determination subsystem may be configured to generate a plurality of scaled raw measurements from the plurality of raw measurements, generate a power spectrum density from the plurality of scaled raw measurements, generate a cumulative distribution from the power spectrum density, and determine a noise distribution from the power spectrum density. A protective action subsystem may monitor the parameter in the electric power system to identify a signal of interest by utilizing, at least in part, the noise distribution and generating a control action in response to the signal.

Abstract: According to a certain embodiment, a test board on which a device under test and a test executable integrated circuit configured to execute a test of the device under test are mounted, includes a first input/output terminal, a second input/output terminal, and a contact unit. The first input/output terminal connects a first measuring apparatus capable of supplying electric power to the test board and controlling the test executable integrated circuit. The second input/output terminal connects a second measuring apparatus capable of measuring electrical characteristics of the test executable integrated circuit. The contact unit is mounted on the test board through the second input/output terminal, and capable of electrically connecting the second measuring apparatus.

Abstract: Systems and methods are provided for detecting defects caused by cracks in an integrated circuit, which may arise during or after a silicon wafer is singulated into separate integrated circuits. An integrated circuit may include crack detection circuitry including a metal circuit. The metal circuit may fracture or break due to crack propagation through a portion of the integrated circuit. In the event of a crack, testing may detect the fracture of the metal circuit. The crack detection circuitry may also detect accurate operation of circuitry of the integrated circuit.

Abstract: An apparatus for testing a wafer or chip comprising a photonic integrated circuit comprises: an electrical signal interface module comprising an array of movable conducting structures; a photonic signal interface module attached to the electrical signal interface module, the photonic signal interface module comprising one or more optical fiber interfaces, and a first set of grating couplers arranged over at least a first plane of the photonic signal interface module; and one or more electrical signal connections between the electrical signal interface module and the photonic signal interface module.

Abstract: An integrated circuit includes a programmable delay path comprising a plurality of path delay tuners configured to receive a plurality of control signals and add to the programmable delay path an amount of cell delay and an amount of wire delay that are based on the plurality of control signals. The integrated circuit further includes a controller configured to provide the plurality of control signals to the programmable delay path, receive a signal from the programmable delay path, and compare the signal to a reference signal.

Abstract: Systems, methods, and devices are described herein for pre-setting scan flip-flops using combinational logic circuits. A system includes a plurality of flip-flop devices and a first pre-setting combinational logic circuit. The plurality of flip-flop devices are coupled together in series and configured to receive a scan input signal, capture data output from each flip-flop device of the plurality of flip-flop devices based on the scan input signal, and generate a scan output signal comprising the captured data. The first pre-setting combinational logic circuit is coupled to a first flip-flop device of the plurality of flip-flop devices. The first pre-setting combinational logic circuit includes a plurality of transistors and is configured to override and set either the scan input signal to the first flip-flop device or the scan output signal of the first flip-flop device based on selective operation of the plurality of transistors.

Abstract: Disclosed is a test board which includes a substrate that includes a device under test (DUT) placement area where a first DUT and a second DUT are disposed, a first load switch connected in series with the first DUT and configured to be set to a switch on state or a switch off state based on a first enable signal, a second load switch connected in series with the second DUT and configured to be set to the switch on state or the switch off state depending on a second enable signal, and a test controller. The test controller may be configured to perform a test operation in a (1-1)-th mode by activating the first enable signal and deactivating the second enable signal and then perform the test operation in a (1-2)-th mode by deactivating the first enable signal and activating the second enable signal.

Abstract: Disclosed is a pressure activation apparatus, and particularly to a pressure activation apparatus with a short-circuiting inspection section for a battery cell, in which a short-circuiting inspection, an activation process, and a charging and discharging process are sequentially and successively performed for a plurality of battery cells within a single pressure activation apparatus, and thus there is no need to separately build short-circuiting inspection equipment, thereby reducing the maintenance, efforts and costs of performing the short-circuiting inspection process, the pressure activation process and the charging and discharging process for the battery cell, and reducing unnecessary waste of space, time, costs, etc. to build the separate equipment.

Abstract: A state of charge (SOC) determination method and apparatus for a battery system are disclosed. Based on a correspondence between impedance and SOC, a correspondence between OCV and SOC, and an operating current at a previous data collection moment, a correction coefficient at a current data collection moment can be determined. After the SOC estimated at the current data collection moment is corrected based on the correction coefficient, the accumulation of errors in the SOC can be eliminated, and the accuracy of the determined SOC is thereby improved.

Abstract: A method for initially preparing an at least partially data-based aging state model for an electrical energy storage means is disclosed. The method includes providing a number of energy storage means on a test bench for measurement based on a respective load profile, wherein the load profiles are different and characterize a chronological trend of at least one load-imposing operational variable for the energy storage means. The method also includes operating the number of energy storage means having the respective associated load profile and recording chronological operational variable trends. Further, the method includes at a predetermined evaluation timepoint, determining an aging state of a subset of the energy storage means as a label based on an input vector, and generating a training data set, which includes the operational variable trends and the determined label, for each energy storage means of the subset of the energy storage means.