Abstract: The present invention relates to compositions and methods for malodor reduction. The malodor control compositions are suitable for use in a variety of applications, including use in consumer products, for example, air freshening compositions, laundry detergents, fabric enhancers, surface cleaners, beauty care products, dish care products, diapers, feminine protection articles, animal and pet litter compositions and plastic films for garbage bags. Such malodor control technologies do not unduly interfere with the scent of the perfumed or unperfumed situs that is treated with the malodor control technology.

Abstract: An air purification system configured to have a flow of air through a first air purification device from ambient air, through an inlet vent into an enclosure, then through a filter, then through a blower, then through UV light rays emanating from a UV light source, then through a spray of disinfectant from at least one disinfectant sprayer, then through a second filter, then out of the enclosure through an outlet vent back into the ambient air.

Abstract: Embodiments of apparatuses and methods for determining a positioning of sensors in a wound dressing are disclosed. In some embodiments, a wound monitoring and/or therapy system can include a wound dressing and a plurality of sensors configured to measure one or more wound characteristics. The wound monitor system can also include at least one positioning device configured to indicate position and/or orientation in the wound of a sensor of the plurality of sensors. In some embodiments, a detector can be configured to determine, based on the positioning data, the position and/or orientation in the wound of the sensor of the plurality of sensors. In some embodiments, the plurality of sensors can be positioned on a strip or string of material in communication with the positioning device.

Abstract: Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.

Abstract: The present disclosure provides devices and methods of using same for cleansing a solution (e.g., a salt or used dialysis solution) of urea via electrooxidation, and more specifically to cleansing a renal therapy solution/dialysis solution of urea via electrooxidation so that the renal therapy solution/dialysis solution can be used or reused for treatment of a patient. In an embodiment, a device for the removal of urea from a fluid having urea to produce a cleansed fluid includes a urea decomposition unit and an electrodialysis unit.

Abstract: The present disclosure relates to a system for extracorporeal blood circulation, including an oxygenator which includes a heat exchanger configured for warming or cooling blood in extracorporeal blood circulation of a patient, and a heater/cooler configured for exchanging a quantity of heat with the heat exchanger, wherein the heater/cooler includes an thermoelectric heater/cooler and wherein the heater/cooler (14) is connected to the heat exchanger (11) by a thermal connecting element (15).

Abstract: An implantable or wearable kidney enclosure that is cylindrical, ovoid, or otherwise non-angular e.g., not rectangular or cuboid), having a circular or oval hemofilter that provides a blood flow pattern from an internal, central artery source radially outwards. Due to the efficient flow of the circular filter design, the enclosure can be made in a cylindrical low profile shape, resulting in a compact enclosure highly suitable for implantable and wearable dialysis applications.

Abstract: A blood processing filter includes a container having 2 ports respectively functioning as an inlet for a liquid to be processed and as an outlet for the processed liquid, and a filtration medium filled in the container, wherein an airflow resistance of the filtration medium is 55.0 kPa·s/m or more and less than 85.0 kPa·s/m, the filtration medium includes a filter material A having an airflow resistance per unit basis weight of 0.01 kPa·s·m/g or more and less than 0.04 kPa·s·m/g and a filter material B having an airflow resistance per unit basis weight of 0.04 kPa·s·m/g or more, at least a part of the filter material A is disposed on a side closer to the inlet for a liquid to be processed than the filter material B, and a sum of airflow resistances of the filter material A is 6.0 kPa·s/m or more.

Abstract: In a blood transfusion system (a blood transfusion kit, a blood transfusion kit for emergency blood transfusion, or a method of using a blood transfusion kit), a flow path through which blood flows is formed using a tube having a channel therein. The flow path includes: a first path that connects an upstream path and a downstream path and has a leukocyte removal filter removing leukocytes at an intermediate position of the channel and a second path that connects the upstream path and the downstream path and bypasses the leukocyte removal filter.

Abstract: A device includes a processor and a non-transitory memory having processor-executable instructions stored thereon. The device is usable with a blood treatment apparatus, such as a hemodialysis machine. The processor-executable instructions, when executed by the processor, facilitate: determining a time point with regard to puncturing a vessel of a patient, wherein puncturing the vessel of the patient is related to a blood treatment for the patient using a blood treatment apparatus; determining a time period based on the determined time point; and transmitting data related to the determined time point and/or data related to the determined time period to a receiving device.

Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Abstract: The present invention relates to a device for flushing a body cavity with a fluid, the fluid being pumped by means of two lines from the body cavity. The respective pumping capacity is regulated via controllable pinch valves, the two pinch valves being coupled in an antiparallel manner.

Abstract: A device for clearing obstructions from a medical tube includes an elongated guide member residing at least partially with the medical tube. In a resting state, clearance members positioned along the guide member are in a low-profile configuration and allow a substantially unobstructed flow through a lumen of the medical tube. In use, the clearance members are in an enlarged-profile configuration to break up and clear obstructions from within the lumen of the medical tube.

Abstract: One implementation of the present disclosure is a negative pressure wound therapy (NPWT) system, according to some embodiments. In some embodiments, the system includes an instillation system configured to provide instillation fluid to a wound site, and a controller. In some embodiments, the wound site includes a wound and a wound dressing. In some embodiments, the controller is configured to provide a first quantity of instillation fluid for a first instillation cycle. In some embodiments, the controller is configured to determine a second quantity of instillation fluid for a second instillation cycle based on the first quantity and a reduction factor. In some embodiments, the second quantity of instillation fluid is less than the first quantity of instillation fluid. In some embodiments, the controller is configured to adjust an operation of the instillation system to provide the second quantity of instillation fluid to the wound site.

Abstract: A dressing interface includes a base that has an aperture and a plurality of microneedles that are attached to the base and disposed over the aperture. The interface also includes a port that is configured to receive a fluid conductor and a conduit that couples the port and the aperture. Each of the microneedles contains a passageway that is fluidly coupled to the aperture. The interface may be used with a drape that is placed over a tissue site. The interface may provide communication between the tissue site and a reduced-pressure source through the microneedles piercing the drape rather than by cutting a hole in the drape.

Abstract: The invention pertains to a capsule system for use with a medical device designed to administer atomized medication to patients. The system features a chamber containing the medication and an atomizer at a lower end for efficient drug delivery. Notably, the system incorporates a fluid sensor and electrical contacts to ensure proper operation and medication delivery. The capsule's design includes a housing with an asymmetrical transverse cross-sectional shape for unique fitting, and a tapered wall to direct medication towards the atomizer. The capsule may also connect to an external container or include a stopper for refilling medication. A specific embodiment features two chambers with a rupturing element to facilitate medication transfer. Another embodiment includes a removable container, like a vial, within the first chamber. This novel system provides improvements in accuracy, versatility, and user-friendliness, overcoming limitations in prior art.

Abstract: A pharmaceutical drug delivery device and method of preventing drying out and drooling of an ejection head for the drug delivery device. The device includes a drug delivery device body; a fluid outlet nozzle attached to the drug delivery device body; and a fluid jet ejection cartridge containing a liquid pharmaceutical drug disposed in the drug delivery device body. A fluid ejection head is attached to the fluid jet ejection cartridge and the fluid ejection head is in fluid flow communication with the fluid outlet nozzle. An elongate, serpentine air flow path is provided between and outer surface of the fluid jet ejection cartridge and an inner surface of the fluid outlet nozzle. The elongate, serpentine air flow path provides a reduced pressure differential adjacent to a surface of the fluid ejection head upon use of the drug delivery device and provides a humidification zone.

Abstract: An inhalation device that makes it possible to reduce the possibility of a user neglecting to replenish the remaining amounts of elements required for inhalation of aerosol or aerosol imparted with flavor.

Abstract: An inhaler article includes a body extending from a mouthpiece end to a distal end with an endpiece element at the distal end. A capsule cavity is defined within the body and extends a cavity length. An air inlet region is between the endpiece element and the capsule cavity. The air inlet region has an air inlet and an air passageway extending from the air inlet to the capsule cavity. The air passageway has an inner diameter less than an inner diameter of the capsule cavity. A porous support element defines a downstream end of the capsule cavity. The porous support element includes one or more apertures extending the length of the porous support element.

Abstract: In one aspect, the disclosure provides apparatuses for and related methods of delivering inhalation airstreams of different temperatures to the nostrils of a subject. Certain embodiments provide apparatuses for and related methods of alternately delivering inhalation airstreams of different temperatures to the respective nostrils of a subject.

Abstract: The disclosure provides a liquid administering device capable of accurately administering a liquid to a predetermined part in a nasal cavity. A liquid administering device 2 includes a main body 4, a first nozzle 6 that protrudes from the main body 4 in a predetermined direction and dispenses a liquid while being inserted into one nasal cavity 28a of a user, and a second nozzle 8 that protrudes from the main body 4 in the predetermined direction and is inserted into the other nasal cavity 28b of the user to position the first nozzle 6 with respect to one nasal cavity 28a.

Abstract: An intelligent ventilator system and operating method thereof are provided. The system includes a ventilator and an input system. The ventilator includes an alarm system, a monitoring system, a communication unit, and a ventilator control system, where the ventilator is configured to apply respiratory treatment to a patient. The input system is configured to input the patient's parameters and treatment requirements to realize recordings of original data of a designed treatment plan. The ventilator control system calculates target data needed by the patient and design the treatment plan, and to control the ventilator. The communication unit is configured for data communication between the input system and the ventilator control system to realize transfer of data from the input system to the ventilator control system. The monitoring system is configured for real-time monitoring of patients, and the alarm system is configured to alarm in time according to the patient's urgency.

Abstract: A respiration therapy appliance having a fan for generating a respiratory air flow for carrying out respiration therapy. The fan comprises at least one rotatable fan impeller having a plurality of blade elements which are arranged on a support disk. The blade elements and/or the support disk have at least one cutout.

Abstract: An anesthesia machine, an anesthetic output concentration monitoring method, system, a device, and a storage medium are disclosed. The method includes respectively monitoring a flow of a fresh gas flowing into a breathing circuit and a flow of an inhaled gas of an anesthetized object. The method further includes when the inhaled gas flow is greater than a fresh gas flow, respectively monitoring a concentration of anesthetic in the inhaled gas and an exhaled gas of the anesthetized object. The method also includes using the exhaled gas anesthetic concentration and a concentration of carbon dioxide in the exhaled gas to calculate a concentration of anesthetic in a gas, reflowing into an inspiratory branch, in the exhaled gas, thereby obtaining a re-inhaled gas anesthetic concentration.

Abstract: A ventilator (1) with a control unit (49). The control unit (49) controls the inhalation valve (41) and the exhalation valve (43) in order to raise an inhalation pressure level from a first pressure level to a predefined second pressure level and to maintain the inhalation pressure level for a first predefined time period and the control unit (49) controls the inhalation valve (41) and the exhalation valve (43) to raise the second pressure level to a predefined third pressure level and to maintain the third pressure level for a second predefined time period. The control unit (49) takes into consideration predefined values (80) for controlling the pressure levels and for controlling the time periods.

Abstract: A rotary occlusion valve for tracheotomy is described, used in the medical field, which allows the function of occluding the flow, both inspiratory and expiratory, of a particular patient, depending on his or her clinical condition or ventilatory limitations, thus permitting the execution of the two steps of respiration, inspiration and expiration. The valve consists in a device composed of a main body in the form of a cylinder inside which is a bearing, a safety grille, a tab, and an oxygen connection port. Said main body is joined to a rotary one-way valve containing a spherical ball, an orifice in its center, windows, pillars, and a tab. Finally, the one-way valve contains a membrane consisting of a grip port and a diaphragm.

Abstract: A ballooning patient interface has a frame that supports a sealing member. The frame and/or the sealing member is secured to the head of a user with headgear, such as a strap. Various features of the sealing member improve comfort for the user in the nares of the users as well as on facial surfaces in contact with the sealing member.

Abstract: Nasal respiratory assembly comprises a pair of sheets. Each sheet defines an opening sized and shaped to fit over the nostril of a patient, with a ferromagnetic ring positioned at an underside of the sheet, with an upper side of the sheet configured for sealable engagement with the nostril. A pair of posts is provided, each post including a magnetic ring positioned at a first end and a receptacle positioned at a second end, the magnetic ring removably attachable to the ferromagnetic ring. A connector is also provided, the connector including a pair of channel openings at a post end, each channel opening sized and shaped to cooperate with one of the post receptacles to form a substantially airtight connection therewith, and an inlet at a vent end that is fluid communication with a flexible tubing connected to a fluid source.

Abstract: An air delivery conduit includes first and second conduit portions that cooperate to form the conduit, each conduit portion including an inner layer of a film laminate that forms an interior surface of the conduit and an outer layer of a textile that forms an exterior surface of the conduit.

Abstract: A portable inhalator device includes a housing with a mouthpiece for a user; a gas conduit coupled to the mouthpiece and configured to guide inhaling and exhaling gas flow within the device; a pressure sensor configured to monitor the gas flow in the gas conduit and to provide pressure differential signal for indicating direction of the gas flow through the gas conduit; a detection sensor configured to monitor the gas flow in the gas conduit and to provide characteristics signal for indicating composition of the gas flow through the gas conduit; and a dispenser configured to dispense a drug to the gas conduit.

Abstract: A cartridge comprising layers of adsorbent sheet is described. The cartridge includes an indicator that characterizes the consumption state of the adsorbent within the cartridge. The indicator is applied in a way such that discrete areas of indicator are visible. These discontinuous areas of indicator may be applied to the outside surface of the cartridge. Alternatively, the discontinuous areas may be formed by cutting windows in the outermost layer of the cartridge and either coating indicator on the layer beneath the window, placing an indicator layer between the window and the layer beneath it or filling the window with an indicating plug of material so that the indicator is visible from the outside of the cartridge. The indicator layer and indicator plug embodiments allow the use of any indicator with any adsorbent.

Abstract: A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.

Abstract: A gas delivery apparatus configured for use with a mechanical ventilator having an atmospheric inlet for drawing in atmospheric gas includes a connecting device configured to connect to an oxygen supply and an air supply and to deliver mixed air and oxygen gas to the atmospheric inlet of the mechanical ventilator. The connecting device further includes a user control for adjusting a fraction of oxygen in the mixed air and oxygen gas. The connecting device comprises a reservoir configured to hold a volume of the mixed air and oxygen gas.

Abstract: A microcatheter with an enhanced inner liner that has low of friction and improved toughness which facilitates delivery of expandable vascular reconstruction devices.

Abstract: To provide a catheter having electrodes to be subjected to application of voltages different from each other in polarity. An outer tube member (3) having a lumen (2); a handle provided on a proximal side of the outer tube member (3); a plurality of electrodes (5) provided on the outer tube member (3); conducting wires (6) connected to one or more of the electrodes (5) and disposed in the lumen (2), the conducting wires (6); and an operating wire (7) having a distal end portion fixed to a distal end portion of the outer tube member (3), wherein one of the electrodes (5a) is connected to a conducting wire (6a) at a connection point, which is different from a connecting point, where another electrode (5b) is connected to another conducting wire (6b), in a circumferential direction of the outer tube member (3).

Abstract: A method for insertion, maintenance, and removal of urethral catheters in mammals including humans includes steps for preventing or reducing the incidence of catheter associated urinary tract infections. In addition to sterile procedures currently practiced or as may be practiced in the future in connection with catheter use, the method includes the steps of applying an antiseptic, zwitterionic, and acidic skincare solution capable of preserving the stratum corneum to the perineum, meatus, and contiguous mucosa surrounding the insertion site before insertion, after insertion, periodically during the period of indwelling, in connection with any incidence of incontinence, and, optionally, before and after removal of the catheter. Application of the solution optionally is continued after catheter removal on a periodic basis until the threat of an infection associated with catheter use has passed, typically at least about five (5) to seven (7) days and up to thirty (30) days.

Abstract: A medical device used to percutaneously gain access to a targeted site within a living body, for example the left ventricle of the heart. The device is comprised of an inner tubular member, outer tubular member, and an adjustable control handle. The control handle can precisely control the relative position of the inner tubular member relative to the outer member by providing feedback to the operator. This feedback provided by the control handle allows the operator to precisely maneuver the catheter within a body and change the shape of the catheter system without taking his/her eyes off the task that he/she is performing. The control handle is designed to precisely change the catheter system from one tip shape to another tip shape and back. Described herein are methods to use such devices.

Abstract: Methods, systems, and devices for facilitation of intraluminal medical procedures within the neurovasculature, the methods, systems and the devices including catheters and catheter advancement elements.

Abstract: A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.

Abstract: A powered catheter and/or powered catheter system is described. The catheter includes a catheter hub with one set of contact components that are configured to connect to a mating cable with a corresponding second set of contact components. The mating cable can be part of another device, such as a controller or power source.

Abstract: An apparatus includes a sheath configured to be at least partially inserted into a body of a patient, the sheath having a distal end and a proximal end; a housing coupled to the proximal end of the sheath; and a control mechanism operably coupled to the housing and slidable to move the sheath relative to the housing. The control mechanism includes a locking mechanism for locking the control mechanism in place relative to the housing; a deflection mechanism for articulating a distal end of the sheath; and a saddle slidable relative to the locking mechanism and the deflection mechanism. A device is coupled to the saddle and is extendable from and retractable within the sheath.

Abstract: A catheter comprises a flexible polymer catheter body including a proximal shaft section and a distal working section, a wire support structure embedded within the distal working section of the catheter body, a proximal adapter mounted to the proximal shaft section of the catheter body, and a wire disposed within the catheter body. The wire has a proximal end and a distal end. The proximal end of the wire being operably connected to the proximal adapter, and the distal end of the wire is anchored to the wire support structure.

Abstract: Devices, systems, and methods are disclosed that help deliver catheters or other medical devices to locations within a patient's body. The device comprises a transporter catheter having a proximal end and a distal end, at least a first balloon located at the distal end, substantially at a tip of the transporter catheter, and at least a second balloon located between the distal end and the proximal end of the transporter catheter. The first balloon is an orienting balloon and the second balloon is an anchor balloon. The transporter catheter may include a single lumen or more than one lumen. The transporter catheter may include a shaft comprising an inner layer and an outer layer, the inner layer may be made of a material more flexible than the material of the outer layer. The outer layer may also comprise a braided wire assembly, said braided wire assembly being formed by braiding a plurality of flat wires or circular wires. The braided wire assembly may wrap around the inner layer.

Abstract: A securement device holds a medical article having flexible portions in position upon the body of a patient and inhibits movement of the medical article. The medical article may be insertable into the securement device from above from below or along a longitudinal axis of the device. The securement device may have abutment surfaces which interact with the flexible portions of the medical article to further inhibit rotation of the device. A securement kit can include a securement device and a catheter.

Abstract: A tube element for a device for introduction into a body passage comprises a first tube element end and a second tube element end, wherein a longitudinal dimension is formed between the first and second tube element end. The tube element has a sheath comprising an outer wall and an inner wall. A cross-sectional element is arranged between the first and second tube element ends. The cross-sectional element contains a plurality of opening arrangements. Each opening arrangement comprises a first opening containing an insert element and a second opening, the internal pressure of which can be changed by a pressure changing means.

Abstract: A method for treating a patient using a catheter insertion device. The catheter insertion device includes a housing, a needle, a catheter, a guidewire, and a thumbwheel. The needle extends through the catheter such that a distal end of the needle extends distal of a distal end of the catheter. The guidewire is coupled to the thumbwheel such that rotation of the thumbwheel advances a distal end of the guidewire through a lumen of the needle. The method includes holding the catheter insertion device, inserting the distal end of the needle and catheter into a blood vessel, rotating the thumbwheel to advance the distal end of the guidewire out of the lumen of the needle into the blood vessel, moving the catheter over the guidewire in the blood vessel, and removing the needle and the guidewire from the catheter.

Abstract: An insertion tool for inserting a catheter into a patient's body includes a housing in which at least a portion of the catheter is initially disposed, a hollow needle distally extending from the housing with the catheter pre-disposed over the needle, and a guidewire pre-disposed in the needle. The insertion tool can include a guidewire advancement assembly that can include a first finger pad for selectively advancing the guidewire distally past a distal end of the needle in preparation for distal advancement of the catheter. The insertion tool can further include a catheter advancement assembly that can include a second finger pad for selectively advancing the catheter into the patient. The first and second finger pads can be positioned such that a user can begin to advance the second finger pad after advancing the first finger pad without substantially re-positioning the thumb or finger of the user.

Abstract: According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece comprising a recess or cavity configured to receive a cartridge or other fluid container, a tip configured to be positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, and at least one rollerball configured to extend to or near the tip, wherein the rollerball is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the at least one rollerball is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball is moved relative to said skin surface.

Abstract: An apparatus is provided for rotatable selection of sites for cannulation with a needle along a subcutaneous vascular access vessel. The cannulation site selection apparatus comprises a template having an inner surface and an outer surface, and a plurality of visible markings on the outer surface of the template. The template is adapted to be disposed adjacent the subcutaneous vascular access vessel such that the markings align with the cannulation sites along the vascular access vessel for selecting a site for cannulation with a needle into the vascular access vessel.

Abstract: A method for rotatable selection of sites for cannulation of a subcutaneous vascular access vessel comprises the step of providing a template defining an opening for a plurality of zones, each of the plurality of zones configured for receiving a plurality of simultaneous cannulations accessing the vascular access vessel. The outer surface of the template is marked, the marking defining each of the plurality of zones for use as cannulation sites along the vascular access vessel. The template is positioned on the skin of the patient adjacent the subcutaneous vascular access vessel such that the opening aligns with the vascular access vessel, and the marking is used for selecting a first zone for a cannulation site into the vascular access vessel such that the cannulation site in the first zone is spaced from and not adjacent to a second zone used for cannulation immediately previously to the first zone.