Patents Issued in March 21, 2024
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Publication number: 20240093108Abstract: In a crude oil purification process including phase separators, a vapor recovery unit (VRU), and dew pointing/dehydration and CO2 removal membranes, instead of compressing the low boiling point (i.e., C1-5) hydrocarbon vapor stream from the VRU along with the main portion of gas from the separation train and feeding it to the membranes, it is compressed and dehydrated along with the H2O/C3+ hydrocarbon enriched permeate from the dew pointing and dehydration membranes.Type: ApplicationFiled: September 21, 2022Publication date: March 21, 2024Applicant: Air Liquide Advanced Technologies U.S. LLCInventor: Sandeep KARODE
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Publication number: 20240093109Abstract: The solvated metal particle-coating system includes a metal additive and a polar outer-sphere electron transferring solvent. The metal additive is solvated in the polar outer-sphere electron transferring solvent. The polar outer-sphere electron transferring solvent may include liquid ammonia, methylamine, and/or hexamethylphosphoramide. The metal additive may include an alkali metal and/or an alkaline earth metal. The solvated metal additive within the polar outer-sphere electron transferring solvent may be used to coat a metal particle and/or a metalloid particle as a layer. As the polar outer-sphere electron transferring solvent evaporates, the solvated metal additive is coupled to the metal particle and/or the metalloid particle.Type: ApplicationFiled: June 2, 2023Publication date: March 21, 2024Inventors: Steven F. Son, Caleb Nathaniel Harper, Ryan Tolman Merrell, Andrew Ryan Noel, Dhruval Natubhai Patel
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Publication number: 20240093110Abstract: A process for using Rice Husk residue as an alternative fuel to fossil fuels (such as Natural Gas and LPP oils 1 A . . . 9 A), in the combustion chamber of the glass, glaze or similar furnace. Where a waste is collected in dump trucks and unloaded into a proper silo, then passes through a dryer feeding silo where it is atomized in the kiln combustion chamber, a high-pressure, low-flow fan is used to atomize it, along with all the necessary air, which can be used in oxy-combustion kilns; all the combustion gases are cooled by mixing with cold air and the incandescent gas from the kiln; and they are then collected and passed through a sleeve filter for proper filtration.Type: ApplicationFiled: August 9, 2023Publication date: March 21, 2024Inventor: Dennis Ricardo Ribeiro
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Publication number: 20240093111Abstract: The disclosure relates to fuel compositions comprising a base fuel, a lubricity modifier, and optional additives, and methods for using same. The base fuel is a middle distillate having a sulfur content of <500 ppm. The lubricity modifier comprises a plant-derived liquid decarboxylated rosin acid and optionally at least one of a fatty acid, a fatty acid derivative, and mixtures thereof. The decarboxylated rosin acid has a flash point of 95-180° C., a density of 0.9 to 1.0 g/cm3 at 20° C., a viscosity of 15 to 60 cSt at 40° C., and an acid value of <50 mg KOH/g. The fuel compositions have desired tribological properties, such as wear scar diameter, coefficient of friction, and percent film, as well as cloud point performance.Type: ApplicationFiled: September 18, 2023Publication date: March 21, 2024Applicant: Kraton Chemical, LLCInventors: Lloyd A. Nelson, Gerald Heebner, Charles D. Moses
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Publication number: 20240093112Abstract: A multiphase composite lubricant for a railway lubricant stick that can be used in both low and high temperature applications. The composition of the multiphase composite lubricant includes an amount of a lubricant, an amount of a thermoplastic lattice components that forms a lattice structure, and a polymer extender.Type: ApplicationFiled: October 19, 2021Publication date: March 21, 2024Applicant: NEW YORK AIR BRAKE, LLCInventors: G. Samuel Benson, Michael Stroder, Craig Shore
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Publication number: 20240093113Abstract: The invention relates to a substrate coated with a coating consisting of molybdenum (Mo), sulfur (S), tantalum (Ta) and oxygen (O) atoms present in the form of one or several compound(s) selected from among the compounds of formula (I): MowSxTayOz??(I) wherein w is equal to 0 or 1; x varies from 0 to 2; y varies from 0 to 1 and z varies from 0 to 3; said coating comprising at least 5% at of oxygen and said coating having a dense compact microstructure.Type: ApplicationFiled: November 30, 2023Publication date: March 21, 2024Applicant: Luxembourg Institute of Science and TechnologyInventors: Jean-Baptiste CHEMIN, Patrick CHOQUET, Guillaume COLAS, Aurélien SAULOT, Michel YANN
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Publication number: 20240093114Abstract: A lubricant adheres to a magnetic recording medium via at least one of chemisorption or bonding, and contains a perfluorinated polyether attached to or terminated with a functional group that is phosphonic acid, silanol or carboxylic acid, and may be: R1—Rf—R1 where Rf is —CF2O(CF2CF2CF2CF2O)n—, —CF2O(CF2CF2CF2O)nCF2—, —CF2O[CF(CF3)CF2O]nCF2—, —CF2O(CF2CF2O)m(CF2O)nCF2—, —CF2O(CF2CF2O)nCF2—, n, m is from 1 to 100 and R1 is the functional group. A lubricant is formed from a multiple ether segments according to formula: Re1—Rb1-Ri-Rc-Ri-Rb2—Re2; where Rc includes perfluoroalkyl ether, Rb1 and Rb2 are, independently, a sidechain segment including a perfluoroalkyl ether, optional Ri independently is a divalent linking segment including a functional group including elements from periodic table Group 13-17, and of Re1 and Re2 are phosphonic acid, silanol or carboxylic acid.Type: ApplicationFiled: May 31, 2023Publication date: March 21, 2024Inventors: Xingliang He, Huaming Xu, Jianming Wen, Charles Cheng-Hsing Lee
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Publication number: 20240093115Abstract: This disclosure describes an ashless lubricant additive. The additive is a tertiary amine-containing compound having the following structure: where R1 and R2 are independently a linear or branched-chain monovalent hydrocarbyl group having two to about twenty carbon atoms, each m is independently from 0 to 2, each p is independently from 0 to 2, for each cyclic moiety m+p is from 2 to 4, and each n is independently from 1 to 6.Type: ApplicationFiled: September 29, 2021Publication date: March 21, 2024Applicants: CHEVRON ORONITE COMPANY LLC, CHEVRON JAPAN LTD.Inventors: William Raymond RUHE, JR., Masami FUCHI, Seyedeh Mahboobeh HOSSEINI
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Publication number: 20240093116Abstract: The present disclosure provides a method for preparing a sulfurized alkyl phenate product to achieve a high sulfurization ratio of sulfurized alkyl phenate to unsulfurized alkyl phenate/phenol in the context of a neutralized and optionally overbased additive. The sulfurized alkyl phenate product is obtained by sulfurizing an alkyl phenol with a sulfur chloride blend that includes about 40 to about 75 weight percent of sulfur dichloride.Type: ApplicationFiled: October 25, 2023Publication date: March 21, 2024Inventors: Mitchell Latimer, Jason Bell
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Publication number: 20240093117Abstract: Provided is an additive to grease comprising a salt including a silicon-containing phosphoric acid ester anion represented by the following formula (1). In the formula, R1 to R3 are independently alkyl groups having 1-4 carbon atoms. R4 is an alkyl group having 1-8 carbon atoms. n is an integer of 1-8.Type: ApplicationFiled: December 22, 2021Publication date: March 21, 2024Applicant: Nisshinbo Holdings Inc.Inventor: Gen Masuda
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Publication number: 20240093118Abstract: The disclosure relates to a lubricating composition consisting essentially of a decarboxylated rosin acid (DCR), a base oil, and optional additives, and methods for using same. The decarboxylated rosin acid has a density of 0.9 to 1.0 g/cm3 at 20° C., a viscosity of 15 to 60 cSt at 40° C., and an acid value of <50 mg KOH/g. The lubricating compositions containing the DCR is characterized as having improved anti-wear and friction reducing properties, as well as improved electrical properties, and cooling performance for use in electric and hybrid vehicles. In embodiments, the lubricating composition exhibits a wear scar diameter of <350 ?m, according to ASTM D6079.Type: ApplicationFiled: September 18, 2023Publication date: March 21, 2024Applicant: Kraton Chemical, LLCInventors: Lloyd A. Nelson, Gerald Heebner, Charles D. Moses, Jeremie Pichereau, Sara Frattini
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Publication number: 20240093119Abstract: Provided is a silicone based anti-foaming agent oil compound that has not only superior anti-foaming speed but also anti-foaming performance that does not degrade with repeated use or use over a long period. The silicone based anti-foaming agent oil compound comprises: (A) an essentially hydrophobic organopolysiloxane with a viscosity at 25° C. of 2,500 to 50,000 mPa·s: 20 to 80 parts by mass; (B) a hydrophobic organopolysiloxane or cyclic organopolysiloxane having silanol groups at least at both terminals: 20 to 80 parts by mass; (C) a silane or silane condensation product: 1 to 10 parts by mass; and (D) a fine powder silica with a specific surface area of 50 m2/g or more: 2 to 10 parts by mass; where the total amount of (A) and (B) combined is 100 parts by mass. Also provided is a method for manufacturing the silicone based anti-foaming agent oil compound.Type: ApplicationFiled: December 23, 2021Publication date: March 21, 2024Inventors: Kazuhiko KOJIMA, Ikutaro MORIKAWA, Tsunehito SUGIURA, Takeshi YOSHIZAWA
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Publication number: 20240093120Abstract: A refrigerator oil composition may effectively suppress an increase in an acid value even when a ratio of an unsaturated fluorinated hydrocarbon compound (HFO) in a refrigerant is increased. Such a refrigerator oil composition can used for a refrigerant and may include one or more unsaturated fluorinated hydrocarbon compounds of formula (1): CxFyH??(1), wherein x is an integer of 2 to 6, y is an integer of 1 to 11, and z is an integer of 1 to 11, and one or more carbon-carbon unsaturated bonds are present in the molecule. The refrigerator oil composition may include a base oil (A), and one or more silicone compounds (B) selected from the group consisting of an unmodified silicone (B1) and a modified silicone (B2), wherein a content of the silicone compound (B) is 0.05% by mass or more based on the total amount of the refrigerator oil composition.Type: ApplicationFiled: March 15, 2022Publication date: March 21, 2024Applicant: IDEMITSU KOSAN CO.,LTD.Inventor: So NAKAJIMA
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Publication number: 20240093121Abstract: The invention relates to a process for improving the efficiency of solvent vapors absorption system and in particular it relates to a continuous process reducing the contaminants released by said solvent vapors absorption system i.e., the concentration of solvent contaminating the discharged air can be reduced by a factor 10 and/or the concentration of the liquid contaminating the recovered solvent is reduced to level below detection limit.Type: ApplicationFiled: September 15, 2023Publication date: March 21, 2024Applicant: DESMET BELGIUMInventors: Timothy KEMPER, Francisco RAMÓN PEREZ VASQUEZ
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Publication number: 20240093122Abstract: The disclosure relates to hard surface cleaning compositions, methods of making the hard surface cleaning compositions, and methods of using the hard surface cleaning compositions. In particular, the hard surface cleaning compositions have reduced surface tension for cleaning surfaces with low surface free energy. Preferably, the hard surface cleaning compositions have low contact angles on a variety of surfaces.Type: ApplicationFiled: November 17, 2023Publication date: March 21, 2024Inventors: Derrick Anderson, Erik C. Olson, Melissa Martinez-Crowley
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Publication number: 20240093123Abstract: Provided is a cleaning composition contained in an aerosol spray can, methods of making and using the cleaning composition, which comprises: a liquid cleaning mixture, comprising: a) a solvent selected from the group consisting of isohexane, isoheptane, and n-heptane and mixtures thereof; b) a de-aromatized hydrocarbon solvent having 7 to 8 carbon atoms in its molecule; c) a branched aliphatic alkane having 10 to 11 carbon atoms; d) from 5 to 15 parts by weight of ethanol, e) from 1 to 15 parts by weight of isopropanol, f) from 1 to 10 parts by weight of acetone, and g) from 0.01 to 0.2 parts by weight of iso-tridecanol polyoxyethylene ether having a HLB value of 12 to 13, and a gas propellant.Type: ApplicationFiled: November 20, 2023Publication date: March 21, 2024Inventors: GuoGuang Liu, HongYu Chu, Bo Xu, Xiaohui Pan, Zengfan Liu
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Publication number: 20240093124Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.Type: ApplicationFiled: April 17, 2023Publication date: March 21, 2024Inventors: Joshua Roy Basler, Michael Stoner, James T. Kellis, Jr., Adam Garske, David Marquez, Katherine Augustyn, Priyanka Chandrasekaran, Miles Christopher Scotcher, Lilia Maria Babe, Richard R. Bott, David A. Estell, Gudrun Vogtentanz, Sina Pricelius, Jian Yao
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Publication number: 20240093125Abstract: The present invention relates to compositions comprising protease variants suitable for use in cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.Type: ApplicationFiled: November 8, 2023Publication date: March 21, 2024Applicant: Novozymes A/SInventors: Peter Kamp Hansen, Esben Peter Friis, Torben Vedel Borchert, Lars Lehmann Hylling Christensen, Jens Erik Nielsen, Maria Berggaard Silow
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Publication number: 20240093126Abstract: Detergent compositions including polypeptide variants and methods of cleaning and/or treatment of surfaces using such compositions, and fabric treatment compositions including polypeptide variants. The compositions may include surfactants: anionic, nonionic and/or cationic.Type: ApplicationFiled: May 3, 2022Publication date: March 21, 2024Inventors: Lars BEIER, Lars Henrik OESTERGAARD, Annette Helle JOHANSEN, Klaus GORI, Thomas Holberg BLICHER, Gernot J. ABEL, Steen KROGSGAARD, Jens E NIELSEN, Lars GIGER, Neil Joseph LANT
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Publication number: 20240093127Abstract: A detergent composition may include xanthan lyase and endoglucanase variants with improved stability. Methods for use of said compositions are also disclosed.Type: ApplicationFiled: January 25, 2022Publication date: March 21, 2024Inventors: Christian DEGERING, Inga Kerstin VOCKENROTH, Brian LAUFS, Piotr TKOCZ, Asbjørn Toftgaard PEDERSEN
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Publication number: 20240093128Abstract: The present invention provides a foamable cleaning agent for an air intake system, comprising: a) 6 to 10 wt. % of ?-sulfo-fatty acid methyl ester salt and/or alpha-olefin sulfonate; b) 6 to 10 wt. % of alkyl polyglucoside APG2000; c) 1.5 to 2.5 wt. % of coconut oil fatty acid diethanolamide and/or lauric diethanol amide LDEA; and d) 5 to 15 wt. % of water; based on the total weight of the foamable cleaning agent, also provided are an aerosol product comprising: an aerosol can containing the foamable cleaning agent, and a spraying device, through which the foamable cleaning agent can be sprayed out as a foam; and a method for preparing the aerosol product, a method of cleaning air intake system with the aerosol product, and a use of the foamable cleaning agent or the aerosol product for cleaning air intake system.Type: ApplicationFiled: November 30, 2023Publication date: March 21, 2024Inventors: GuoGuang Liu, HongYu Chu, Bo Xu, Xiaohui Pan, Zengfan Liu
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Publication number: 20240093129Abstract: The present invention relates to water-soluble unit dose articles comprising a liquid laundry detergent composition which comprises polyethylene glycol having a weight average molecular weight of from about 150 to about 300 Daltons.Type: ApplicationFiled: August 24, 2023Publication date: March 21, 2024Inventors: Qiuyang HE, Yanjie WENG, Ming TANG
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Publication number: 20240093130Abstract: A partitioned solution cartridge for automatic distribution of dishwashing chemicals includes a protective top film and a compartmentalized body including a plurality of contained solution sectors each including a fluid reservoir and a distribution chamber. The fluid reservoir is partially enclosed by a reservoir sidewall and the protective top film. The distribution chamber is partially enclosed by a chamber sidewall and the protective top film. The fluid reservoir and the distribution chamber are fluidly connected.Type: ApplicationFiled: September 15, 2023Publication date: March 21, 2024Inventors: Paulus Antonius Augustinus HOEFTE, Vincent Hubert Monique DE WILDE
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Publication number: 20240093131Abstract: A partitioned solution cartridge for automatic distribution of dishwashing chemicals includes a protective top film and a compartmentalized body including a plurality of contained solution sectors each including a fluid reservoir and a distribution chamber. The fluid reservoir is partially enclosed by a reservoir sidewall and the protective top film. The distribution chamber is partially enclosed by a chamber sidewall and the protective top film. The fluid reservoir and the distribution chamber are fluidly connected.Type: ApplicationFiled: September 15, 2023Publication date: March 21, 2024Inventors: Paulus Antonius Augustinus HOEFTE, Vincent Hubert Monique DE WILDE
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Publication number: 20240093132Abstract: A method and a device for adherent culture of microalgae in a thin liquid layer by mobile mechanical stirring, comprising: a subsystem for adherent culture of microalgae in thin liquid layer, for adherent culture of microalgae in a culture solution, comprising a microalgae liquid pool and a culture plate used as a base plate for microalgae seed inoculation, adherent culture, microalgae harvesting, the microalgae liquid pool containing culture solution having a water layer with a depth in a range of 1{tilde over (?)}5 cm, forming a thin liquid layer; and a subsystem for mechanical stirring, comprising a mechanical stirring assembly, a moving assembly, a track member, a power drive assembly, a control assembly, the moving assembly moving on the track member to drive the mechanical stirring assembly to stir and suspend the microalgae, the microalgae standing and gradually settling to the bottom after stirring, realizing adherent culture in suspension and settlement cycle.Type: ApplicationFiled: July 29, 2020Publication date: March 21, 2024Inventor: Xuyang SUN
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Publication number: 20240093133Abstract: An embryo culture device that accommodates a plurality of trays that each accommodate a treatment egg having been subjected to insemination treatment, and keeps the plurality of trays in a culture environment includes: a culture unit that keeps the plurality of trays in the culture environment; and a plurality of imaging units that are each provided in association with each one of the trays held in the culture unit, and continuously or intermittently image locations of the trays. An image captured by each of the imaging units is stored in a storage unit per tray. The image stored per recess part is corrected, and the corrected image is displayed on a display unit.Type: ApplicationFiled: January 20, 2021Publication date: March 21, 2024Inventor: Noritaka Fukunaga
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Publication number: 20240093134Abstract: Provided is a culture chamber capable of preparing spheroids with a uniform size with high efficiency and having a micro-space structure which is designed to facilitate replacement of a medium and harvesting of cells. The culture chamber includes a plurality of recesses (10) each formed of a bottom portion (11) and an opening portion (12). The bottom portion (11) has one of a hemispherical shape and a truncated cone shape and the opening portion (12) is defined by a wall that surrounds an area from a boundary between the opening portion (12) and the bottom portion (11) to an end of each of the recesses (10), the wall having a taper angle in a range from 1 degree to 20 degrees. An equivalent diameter of the boundary is in a range from 50 ?m to 2 mm and a depth from a bottom of the bottom portion (11) to the end of each of the recesses is in a range from 0.Type: ApplicationFiled: November 28, 2023Publication date: March 21, 2024Inventors: Yoko Ejiri, Satoru Ayano, Naoto Fukuhara, Hideki Taniguchi, Takanori Takebe
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Publication number: 20240093135Abstract: A base element of a multi-chamber biochip has a bottom with a frame situated thereon, open on its side facing away from the bottom, wherein an interior space is enclosed by the frame. Furthermore, at least one first web is present; however, preferably a first web and a second web are present. Culture chambers formed by the webs and the frame, and delimited from one another via membranes, are contacted via channels, and serve to generate biological model systems. The base element is in particular formed as a single piece (monolithically). A multi-chamber biochip, a set, and a method for making a multi-chamber biochip are also disclosed.Type: ApplicationFiled: September 18, 2023Publication date: March 21, 2024Inventors: Nader Abdo, Knut Rennert, Martin Raasch
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Publication number: 20240093136Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: ApplicationFiled: November 28, 2023Publication date: March 21, 2024Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher Davidd Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Publication number: 20240093137Abstract: A sparger assembly for a bioprocessing system includes a base and a plurality of spargers connected to the base, each sparger including a plurality of pores, the plurality of spargers each have a generally cylindrical shape. Each of the plurality of spargers includes a sidewall and a top, which define the cylindrical shape, the sidewall and the top each include a plurality of pores. The pores of the sidewall can be arranged around a circumference of the sidewall at an array of heights. Ridges may also be located on the sidewall above a respective array of pores.Type: ApplicationFiled: September 19, 2022Publication date: March 21, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventor: RAFAEL DIANA
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Publication number: 20240093138Abstract: Aspects of the present invention relate to an automated cell culture instrument and to methods for operating such an instrument. In one aspect, the cell culture instrument includes a computing unit and a plurality of electrically controllable resources (e.g., sensors, actuators, etc.). The computing unit receives a protocol, schedules the resources so as to execute the protocol, and operates the resources as scheduled or in response to so as to provide an improved environment for cell culture growth. The computing unit may simulate protocol execution in connection with the scheduling or execution of the protocol.Type: ApplicationFiled: November 16, 2023Publication date: March 21, 2024Inventors: Howard Cannon, Keith Moulton
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Publication number: 20240093139Abstract: A mycelium composite material includes a fungi generated mycelium fiber matrix and a biofiller (organic or inorganic or combined) dispersed within the matrix. The biofiller provides a structural element and nutrition source for the fungi and the mycelium fibers bind the biofiller.Type: ApplicationFiled: September 15, 2023Publication date: March 21, 2024Inventors: Xiong Yu, Xijin Zhang
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Publication number: 20240093140Abstract: Provided herein are compositions and methods for reducing bacterial contamination during cell culture. Such compositions and methods utilize engineered peptides or recombinant cells capable of secreting such peptides into culture medium. Also provided are methods of using the engineered peptides for inhibiting bacterial growth during culturing of cells.Type: ApplicationFiled: September 8, 2023Publication date: March 21, 2024Inventors: Steve Good-Sung Wong, Hendrik Jurgens Jansen Van Vuuren
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Publication number: 20240093141Abstract: A bacterial strain of the genus Xanthobacter and continuous culture processes for the production of protein or biomass using bacteria of the genus Xanthobacter, said process including supply of gases and minerals to the cells. The present disclosure also relates to the products of these processes and use of these products in e.g. food or feed. Reference is made to the Identification of the Microorganism, having the Identification reference given by the DEPOSITOR of SoF1 and with the Accession number given by the INTERNATIONAL DEPOSITORY AUTHORITY of VTT E-193585. The date of the original deposit is Jun.Type: ApplicationFiled: October 22, 2020Publication date: March 21, 2024Applicant: Solar Foods OyInventors: Sami HOLMSTRÖM, Juha-Pekka PITKÄNEN
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Publication number: 20240093142Abstract: The present invention relates to the fields of microorgan-isms, feed, food and ecological restoration, in particular to a strain for degrading deoxynivalenol (DON) and the use thereof. The strain has the deposit number CCTCC No. M 2020565. The strain can grow by means of taking the toxic compound DON as a sole carbon source, and convert the DON into chemical components for itself. The reaction process is irreversible, the reaction conditions are moderate, and secondary pollu-tion cannot be caused. The strain provided in the present invention can be used for preparing a biological detoxification preparation for DON. The strain provided in the present invention can be used for degrading DON in feed and food raw materials, primary processing products, deep processing products and related processing byproducts. The strain provided in the present invention can be applied to various ecosystems such as soil or bodies of water polluted by DON to achieve the purposes of DON degradation and ecological restoration.Type: ApplicationFiled: November 11, 2021Publication date: March 21, 2024Inventors: Huiying LUO, Honghai ZHANG, Bin YAO, Huoqing HUANG, Yaru WANG, Yingguo BAI, Xiaoyun SU, Yuan WANG, Tao TU, Jie ZHANG, Huimin YU, Xing QIN, Xiaolu WANG
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Publication number: 20240093143Abstract: Cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. Compositions comprising polypeptides produced by the methods are also provided.Type: ApplicationFiled: October 30, 2023Publication date: March 21, 2024Applicant: GENENTECH, INC.Inventors: Natarajan Vijayasankaran, Steven J. Meier, Melissa S. Mun, Sharat Varma, Yi Yang, Boyan Zhang, Silvana R. Arevalo, Martin Gawlitzek, Veronica Carvalhal
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Publication number: 20240093144Abstract: Disclosed herein include methods and compositions for use in generating synthetic embryos. In some embodiments, the method comprises culturing stem cells that over-express at least one Cadherin.Type: ApplicationFiled: September 1, 2023Publication date: March 21, 2024Inventors: Min Bao, Magdalena Zernicka-Goetz
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Publication number: 20240093145Abstract: Methods of generating spinal cord glutamatergic interneurons (V2a interneurons) from human pluripotent stem cells (hPSCs) are provided. A method of the present disclosure may include culturing a first population of hPSCs in vitro in a neural induction medium that includes: a retinoic acid signaling, pathway activator; a sonic hedgehog, (Shh) signaling pathway activator; and a Notch signaling pathway inhibitor, wherein the culturing results in generation of a second population of cultured cells containing CHX10+ V2a interneurons. Also provided are non-human animal models that include the hPSC-derived spinal cord glutametergic interneurons, and methods of producing the non-human animal models.Type: ApplicationFiled: June 28, 2023Publication date: March 21, 2024Inventors: Jessica Butts, Todd C. McDevitt
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Publication number: 20240093146Abstract: According to the present disclosure, there is provided a method for producing oligodendrocytes and progenitor cells thereof, comprising introducing inducers including a combination of OLIG and SOX or a combination of OLIG and NKX into iPS or ES cells. According to the present disclosure, there is also provided a method for producing oligodendrocytes and progenitor cells thereof, comprising introducing inducers including OLIG, SOX, ASCL, and NKX into somatic cells.Type: ApplicationFiled: January 19, 2022Publication date: March 21, 2024Applicants: I Peace, Inc.Inventor: Koji TANABE
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Publication number: 20240093147Abstract: The present disclosure relates to a method for producing novel glia-like cells that are differentiated from somatic cells and secrete 20,000 pg/ml or more of Hepatocyte growth factor (HGF), 150 pg/ml or more of Brain-derived neurotrophic factor (BDNF), and 10 ng/ml or more of Macrophage migration inhibitory factor (MIF), using a chemical cocktail composition for producing the same.Type: ApplicationFiled: November 9, 2023Publication date: March 21, 2024Inventors: Kyeong-Kyu Kim, Debojyoti De
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Publication number: 20240093148Abstract: Provided are a method for differentiating human induced pluripotent stem cells into oligodendrocytes, and a kit and the use. The method comprises culturing stem cells by means of using at least one of the following culture media: a neural induction complete culture medium, an N2 culture medium, a B27 culture medium and an OPC maturation culture medium. More preferably, the induction of oligodendrocytes by an OPC maturation culture medium with puerarin increases the number of oligodendrocytes by 30% compared with a culture medium without puerarin.Type: ApplicationFiled: November 28, 2023Publication date: March 21, 2024Applicant: ALLIFE MEDICINE (ZHUHAI) LIMITEDInventors: Lida WU, Yuchun GU
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Publication number: 20240093149Abstract: The present invention relates to population of T cells with reduced expression of SIGLEC15, wherein the T cells are derived from sentinel lymph nodes in a subject having a cancer. The invention also relates to methods for obtaining such T cells, as well as to their use in therapy and pharmaceutical compositions comprising such T cells.Type: ApplicationFiled: December 1, 2021Publication date: March 21, 2024Inventors: Yuan Yang, Hang Du, Jingling Tang, Pingsheng Hu
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Publication number: 20240093150Abstract: There is described herein a method for improving the anti-cancer properties of T-cells, the method comprising: providing a population of T-cells; and culturing the T-cells in an environment that activates the GCN2 pathway.Type: ApplicationFiled: January 18, 2022Publication date: March 21, 2024Inventors: Pamela OHASHI, Sam SAIBIL, Michael ST. PAUL
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Publication number: 20240093151Abstract: The present invention relates to methods for producing immuno-stimulatory antigen-presenting cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer.Type: ApplicationFiled: April 12, 2023Publication date: March 21, 2024Inventors: Günter BAUER, Richard EDELSON, Karsten HENCO, Justin DUCKWORTH
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Publication number: 20240093152Abstract: The present disclosure relates to cultured tissue, methods for production of self-sufficient modified cells for producing cultured tissue. Further, the disclosure provides methods of generating cultured meat products without exogenous addition of growth hormones.Type: ApplicationFiled: November 12, 2021Publication date: March 21, 2024Inventors: David L. Kaplan, Andrew Stout, John Yuen, JR., Natalie Rubio
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Publication number: 20240093153Abstract: A method for meat production by in vitro cell culture includes isolating tissue from an animal or plant source and making a cell suspension of cells, and growing the cells into a solid or semi-solid structure that mimics an animal organ by growing the cells on a food grade scaffold in a culture medium. Expression of one or more proteins in the growing cells may be increased by altering a level of one or more micro RNAs that regulate expression of the protein. Additionally, the growing cells may be co-cultured with bioengineered cells that secrete growth factors and cytokines that support the growth of the cells in situ. The co-culturing technique reduces or eliminates the need for animal-derived fetal bovine serum in the culture medium.Type: ApplicationFiled: July 28, 2020Publication date: March 21, 2024Applicant: Avant Meats Company LimitedInventors: Po San Mario CHIN, Kai Yie Carrie CHAN, Chun Hei POON
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Publication number: 20240093154Abstract: Diabetes is a clinical condition that affects millions of people worldwide, and is treated by insulin replacement therapies. New strategies to create scalable and compatible pancreatic islets containing insulin-producing beta cells are necessary as an alternative to limited supply of cadaveric islets or multiple exogenous insulin applications. Improvements are still necessary since many immature polyhormonal cells remain, and cannot attain a monohormonal state. During human development, pancreas co-develops with endothelium and shares signals, allowing for better maturation of beta cells, and this is not included in the current differentiation protocols. The organchip microfluidic devices allows dynamic co-culture of different cells, thus resembling in vivo physiology. Here the Inventors establish organ-chip models co-culturing human iPSC-derived pancreatic precursors with iPSC-derived endothelial cells to obtain more functional and monohormonal iPSC-derived beta cells.Type: ApplicationFiled: January 31, 2022Publication date: March 21, 2024Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Dhruv Sareen, Roberta de Souza Santos
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Publication number: 20240093155Abstract: The present invention relates to a method of expanding stem cells cultured as cell aggregates in a suspension culture changing culture medium and a method of medium exchange for the same cells characterized in the use of a rotating mesh such as a spinfilter device. The present invention further relates to a use of a rotating mesh for medium exchange in a suspension culture of stem cells.Type: ApplicationFiled: January 21, 2022Publication date: March 21, 2024Applicants: SARTORIUS STEDIM BIOTECH GMBH, REPAIRON GMBHInventors: Luis HAUPT, Julia HUPFELD
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Publication number: 20240093156Abstract: The disclosure provides methods and compositions for reprogramming fibroblasts into limb progenitors.Type: ApplicationFiled: August 15, 2023Publication date: March 21, 2024Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.Inventors: Clifford J. Tabin, Yuji Atsuta, Alan R. Rodrigues, ChangHee Lee, Olivier Pourquie
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Publication number: 20240093157Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.Type: ApplicationFiled: November 15, 2023Publication date: March 21, 2024Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Rocky S. Tuan, Hang Lin, Thomas P. Lozito, Peter Alexander, Douglas Allen Nelson, Jr., Riccardo Gottardi