Abstract: An UV disinfection system (200) may feature a chamber (207) with internal spherical reflective surfaces (208) to evenly reflect UV radiation from all angles to direct the UV radiation to all surface area of the object inside the chamber to disinfect object utilizing UV radiation under controlled time. An object (215) to be disinfected may reside within the chamber (207) on a UV transparent rack or shelf (214). The spherical reflective surfaces may be fashioned by placing such surfaces on a polyhedral internal structure or making the internal chamber spherical in and of itself (208). Multiple UV sources (209a), (209b) may also be utilized.

Abstract: An active plasma sterilizer (APS) system for sterilization/decontamination is provided, including a sterilization box and a plurality of compact portable plasma reactors (CPPRs) disposed in the sterilization box and configured for generating surface dielectric barrier discharge (SDBD) for generating and distributing reactive oxygen and nitrogen species (RONS) such as ozone. Each of the plurality of CPPRs includes a reactor panel and a power supply circuit. The reactor panel includes one or more electrodes separated by a dielectric medium. The active plasma sterilizer (APS) system may include an ozone decomposition module having a heating element connected to a power supply and configured to decompose ozone by heating ozonated air; a power supply module for supplying power to the heating element; connecting pipes for providing paths for ozonated air to travel through; and an air pump configured to circulate the ozonated air generated.

Abstract: The invention relates to a device and method for dispensing volatile substances, in particular fragrances and/or active ingredients, and comprises a housing (2), a container (5) for the substance (6) to be dispensed and a wick (18) as capillary element which is in contact with the substance (6) to be dispensed and which has a wick-side substance-dispensing region (20). According to the invention the device (1) has a temperature measuring device for direct or indirect measurement of the wick temperature (TD) at the wick-side substance-dispensing region (20), having at least one temperature sensor (13, 14) and having a measuring value output at which, during operation, an electrical wick temperature measuring signal corresponding to the currently measured wick temperature (TD) is supplied. The device (1) has furthermore an open-loop control device or a closed-loop control device for controlling the wick temperature (TD) at the wick-side substance dispensing region (20).

Abstract: The present specification relates to a plasma and VHP combined sterilizer comprising a housing. More particularly, the plasma and VHP combined sterilizer comprises: a discharge unit, which is provided at the upper end of a housing and discharges predetermined amount of vaporized hydrogen peroxide; a suction fan, which is provided at one side of the housing and suctions the outer air and discharged hydrogen peroxide; a plasma generation unit including a plurality of plasma modules for generating the outer air and hydrogen peroxide, which are suctioned through the suction fan, as plasma ions through plasma discharge; and a control unit for controlling the overall operation of the plasma and VHP combined sterilizer.

Abstract: Systems and methods for creating a germicidal partition. A germicidal partition system including at least one negative ion generator including at least one negative high-voltage source, at least one high-voltage conductor electrically connected to the at least one negative high-voltage source, and at least one anode electrically connected to the at least one high-voltage conductor, and at least one fan configured to draw air into the system, direct the air through the at least one negative ion generator, and output the air through at least one manifold, wherein the air outputted through the at least one manifold is configured to create a barrier between a first air mass and a second air mass, such that the outputted air reduces at least one of the transfer of contaminants or the concentration of viable contagions between the first air mass and the second air mass.

Abstract: The present invention relates to the use of hydrogel in the treatment of pressure ulcers and/or in the prevention of the formation of pressure ulcers, particularly of pressure ulcers caused by devices or by medicinal products.

Abstract: Described herein are embodiments of a wound dressing layer. The wound dressing layer may include an open-cell foam. The foam may have a 50% compression force deflection of not more than about 4.8 kPa. The foam may also have a density of at least 24 kg/m3. The foam may exhibit a density increase of a factor of at least 12 at about ?75 mmHg.

Abstract: A composition comprising a plurality of electrospun fiber fragments comprising at least one polymer, a plurality of electrospun fiber fragment clusters comprising at least one polymer, and, optionally, a carrier medium, is disclosed. Also disclosed is a kit comprising a first component of a plurality of electrospun fiber fragments, and a second component of a carrier medium. Also disclosed is a composition comprising a plurality of micronized electrospun fiber fragments, a carrier medium, and, optionally, a plurality of cells. Also disclosed is a biocompatible textile comprising a plurality of micronized electrospun fiber fragments. Also disclosed is a biocompatible suture comprising at least one electrospun fiber.

Abstract: The present invention provides radioactive glass microspheres for embolization and a preparation method and an application thereof. A nuclide oxide and a foaming agent are added into a glass matrix, blended and uniformly mixed for making the foaming agent decomposed and vaporized at a high temperature to generate bubbles, so as to prepare the radioactive glass microspheres for embolization with cavities. The radioactive glass microspheres for embolization have a density of 1.4-2.3 g/cm3, a nuclide loading rate of 15-40 wt % and a higher and more stable radiation dose, can achieve better distribution and deposition effects in liver blood vessels after injection, and can achieve a better therapeutic effect for hepatocellular carcinoma (HCC).

Abstract: The present invention relates to silk fibroin bioinks specifically formulated for use in 3D bioprinting and the production of ex-vivo models capable of supporting hematopoiesis and the production of platelets and blood cells.

Abstract: Medical articles formed from ionically bonding an ionic compound and an active agent provide enhanced properties. The ionic compound comprises an ionic additive incorporated into a base polymer. The ionic additive may be one or more of an anionic additive, a cationic additive, and a zwitterionic additive. Medical articles herein have antimicrobial, anti-fouling, and/or antithrombotic characteristics.

Abstract: The present invention relates to a transdermal photocuring forming hydrogel with biological activity. The hydrogel can release recombinant collagen with biological activity, the recombinant collagen includes a sequence as shown in SEQ ID No. 1, an amino acid sequence of the recombinant collagen includes N basic repetitive units, and each basic repetitive unit includes n1 of the following characteristic amino acid sequences: “G-Xaa1-Xaa2-G-E-Xaa3”; the 3? end and the 5? end of the basic repetitive unit are connected to form the above characteristic amino acid sequence. The recombinant collagen provided by the present invention has relatively obvious integrin binding activity, and has the effects of promoting cell adhesion, proliferation and differentiation. The hydrogel of the present invention has good biocompatibility and stable quality, which can be cured and formed in situ in a transdermal photo-crosslinking manner after injection, with simple, convenient and controllable operation.

Abstract: Some embodiments of the disclosure provide a decellularized heart valve (DHV) composite, a preparation method of the DHV composite, and a use of the DHV composite. In some examples, the preparation method of the DHV composite includes the following steps: S1, conducting a reaction I on a DHV with a copper chloride-dopamine hydrochloride mixed solution to obtain a copper ion-modified DHV; and S2, conducting a reaction II on the copper ion-modified DHV with a GDF11 solution to obtain the DHV composite. In other examples, the present disclosure provides a use of the DHV composite in preparation of a tissue-engineered heart valve (TEHV). In further examples, the TEHV is a heart valve (HV) with remodeling and regeneration capabilities.

Abstract: Tissue grafts with reduced regenerative potential, methods of preparing such grafts, and related kits and methods of treatment are described. The method may include treating tissue with a digestion solution comprising trypsin, alpha-chymotrypsin (ACT) and optionally ethylenediaminetetraacetic acid (EDTA) to substantially remove one or more susceptible proteins from the tissue. The method may also include washing the treated tissue with a buffer solution and/or with a serine-containing serum. Nerve grafts prepared according to the disclosed methods may inhibit, or lessen (e.g., provide for reduced) neuroma formation and/or axonal outgrowth after implantation.

Abstract: Engineered tissue compositions for supporting cell growth, maintenance, and/or differentiation featuring a scaffold, including a dual fiber scaffold, extracellular matrix (ECM) material, and optionally a population of ECM-generating cells such as fibroblasts. The tissue compositions may be used for supporting seeded cells of a particular cell type of interest such as cells related to skeletal muscle, smooth muscle, cardiac tissue, gastrointestinal tissue, etc. The tissue compositions with seeded cells may develop into functional tissues, which may have the potential to provide a tissue graft for therapeutic purposes or a valuable model for in vitro assays.

Abstract: The invention is directed to a porous osteoinductive composite comprising osteoinductive granules embedded in a porous matrix, wherein more than 5% of the surface area of the osteoinductive granules is exposed from said matrix as determined by scanning electron microscopy (SEM) imaging. Such a composite can suitably be used in a medical treatment, for example in a medical treatment of connective tissue and/or bone loss or defect.

Abstract: A sealing member for an implantable prosthesis includes a substrate comprising a substrate material, and one or more hydrogel structures disposed on an outwardly facing surface of the substrate. The hydrogel is stimulus responsive, and undergoes a change in volume, stiffness, or both when exposed to the stimulus. The sealing member promotes endothelialization and/or reduces paravalvular leakage.

Abstract: The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses there e.g., in treating a condition in a subject in need thereof. The devices may be coated with therapeutic agents, such as those that promo bone growth, and/or seeded with cells to generate devices for use in tissue replacement and grafting.

Abstract: The present invention is directed to a shape memory alloy, particularly a Fe-based shape memory alloy, that is suitable for use in additive manufacturing methods, as well as methods of use and methods of altering the composition of the alloy during fabrication.

Abstract: The present invention relates to an acellular skin substitute for breast reconstruction and a preparation method therefor. In the present invention, an acellular skin substitute may be prepared through the removal of epidermal layers and an acellularization process, in which the use of a proteolytic enzyme and a surfactant is excluded. In addition, since the acellular skin substitute is cut into suitable sizes and shapes to cover a breast reconstruction implant through design software and then cut out with a CNC machine, the time for breast reconstruction surgery may be reduced, and since no dead space is formed after suturing, the incidence of seromas may be reduced. Accordingly, the side effects of surgery may be lessened.

Abstract: Described herein are compositions comprising a nitric oxide releasing material comprising a (i) a polysiloxane network and (ii) a plurality of nitric oxide-donating moieties covalently bonded to the polysiloxane network; and (b) a silicone oil. Also described herein are articles composed of the compositions described herein and methods for using the same. The compositions described herein provide highly sustained, long-term nitric oxide release that have numerous biological activities such as, for example, preventing localized platelet activation, fibrinogen adhesion, and biofilm formation for a prolonged period of time.

Abstract: Disclosed is an anti-adhesion agent composition which uses a high molecular weight compound having biocompatibility and an oil derived from animals, plants, and minerals so as to improve low viscosity and low strength, which are problems of existing anti-adhesion agents, and prevent adhesion between living tissues. The anti-adhesion composition according to the present disclosure performs a physical barrier function through simple mixing of a polymer material, serving as a physical barrier in its anti-adhesion effect, and a solvent, and remains in the body for a certain period of time, then decomposes, absorbs, and is excreted. The anti-adhesion composition does not interfere with the healing of the wound after surgery, and exhibits an excellent effect of convenient application to the surgical site.

Abstract: The purpose of the present invention is to provide a pre-filled syringe formulation with staked needle, which contains an antibody at a high concentration and can be produced on an industrial scale in a simple manner without causing clogging. A pre-filled syringe formulation with staked needle, in which a protein solution is packed. The pre-filled syringe formulation is characterized in that a cap formed with a material having low water vapor permeability is provided at the needle.

Abstract: An auxetic web structure or field structure useful for a medical implant, combining the advantageous mechanical properties of auxetic structures and stretchable interconnects in such a way as to provide an auxetic structure which is particularly stretchable, while at the same time providing sufficiently large areas which are subjected at most to only minor stresses. This structure takes advantage of the superior mechanical properties offered by auxetic metamechanical materials (hereafter referred to as auxetic) and improves their stretchability and compressibility by incorporating interconnects into the auxetic framework.

Abstract: A blood reinfusion system for processing autologous blood for reinfusion into a patient. The system includes a suction container adapted to receive a mixture of autologous blood and impurities and extract the impurities from the mixture, a blood filter assembly adapted to further extract the impurities from the mixture, whereby whole purified autologous blood is obtained, and a blood transfer bag adapted to receive the whole purified autologous blood from the blood filter assembly.

Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.

Abstract: A mobile interface cart including a storage tank for receiving effluent from a dialysis (e.g., hemodialysis) procedure and a pump for pumping the effluent from the storage tank to an external waste drain located in the treatment center. In use, the pump enables the effluent to be moved over greater distances and/or around obstacles thereby eliminating, or at least minimizing, the need to construct expensive and time-consuming waste drains in the treatment center.

Abstract: Disclosed is a method for treating a renal condition by loco-regional perfusion of one or both of a patient's kidneys (1810). A closed circuit may be formed with a perfusion catheter (1822) positioned in the renal artery of the kidney, a recovery catheter (1824) positioned in the renal vein of the kidney, and an external membrane oxygenator (1820) disposed therebetween. A perfusate containing, for example, a drug may be circulated through the closed circuit while isolating the closed circuit from the patient's systemic circulation.

Abstract: Absolute blood volume in dialysis patients is a useful patient attribute to know for dialysis treatment, diagnosis, adjustments, etc. In some cases, it is difficult or impossible to directly determine absolute blood volume. Estimating absolute blood volume may be used to overcome the inability to directly determine the absolute blood volume. Estimating absolute blood volume may include obtaining a series of measurements of hemoconcentration of a patient over a time period, and estimating parameters for a physiological model based on the series of measurements. The absolute blood volume of the patient may be determined using the physiological model.

Abstract: The invention relates to a medical apparatus designed to receive a detachable fluid-conducting first line portion (3). The medical apparatus comprises a second line portion (2) designed to be connected to the first line portion (3), wherein a movable element (38) is situated in the second line portion (2), by means of which movable element the second line portion (2) is separated into a first sub-portion (2a) and a second sub-portion (2b).

Abstract: A blood purification apparatus includes a line section, a duplex pump, and a control unit. The line section includes a dialysate introduction line and a drain-liquid discharge line. The control unit is configured to execute a blood purification treatment process and a defatting washing process. The blood purification treatment process is executed when blood purification treatment is performed in which dialysate is delivered to a dialyzer. The dialysate is prepared by mixing an A-drug solution and a B-drug solution introduced into the line section and diluting the A-drug solution and the B-drug solution to predetermined concentrations. The defatting washing process is executed when defatting washing is performed in which oil and fat in the line section is removed by causing a sodium carbonate solution to flow through the line section. The sodium carbonate solution is obtained by heating the B-drug solution introduced into the line section.

Abstract: In some embodiments, a medical system includes a dialysis machine having at least one outer surface to be disinfected at a given location, at least one disinfection sensor connected to the dialysis machine at the given location, the disinfection sensor including two or more electrode in fluid contact with the outside surface of the dialysis machine, and a conductivity sensor component in electrical contact with the two or more electrodes, the conductivity sensor component configured to send an electrical signal indicating a conductivity of a liquid on an outside surface of the dialysis machine and in contact with the two or more electrodes, a processor configured to receive the electrical signal and thereby determine a disinfection status of the given location, and a user interface configured to indicate the disinfection status of the given location.

Abstract: A system for performing extracorporeal blood treatment of recovered blood can include a reservoir to receive a first portion of the recovered blood from a subject, an inline pump coupled the reservoir to regulate a flow rate of at least the first portion of the recovered blood, and an extracorporeal blood conditioner including at least one of an oxygenator to reoxygenate hemoglobin included in the recovered blood for at least intravenous delivery back to the subject or a temperature regulator configured to selectively control a temperature of the recovered blood.

Abstract: An apparatus for removing CO from blood, the apparatus including: a housing configured to house blood obtained from a body of a subject within an interior of the housing; a plurality of gas-permeable tubules disposed within the interior of the housing; an optical intrusion coupled to the housing and configured to project into the housing, the optical intrusion configured to transmit light into the interior of the housing; and a light source optically coupled to the optical intrusion, the light source being configured to emit light which is coupled via the optical intrusion into the interior of the housing such that the emitted light interacts with the blood from the body of the subject.

Abstract: A valve assembly for controlled drainage or delivery of a fluid from or to a patient including an outlet, an inlet, a diaphragm chamber and a diaphragm dividing the diaphragm chamber into a first chamber cavity and a second chamber cavity. The diaphragm being deflectable toward a first wall of the diaphragm chamber wherein the first chamber cavity contracts and the second chamber cavity expands, and oppositely toward a second wall of the diaphragm chamber wherein the second chamber cavity contracts and the first chamber cavity expands. A plunger is translatable between a first actuation state that establishes fluid communication between the outlet and the second chamber cavity, and separately between the inlet and the first chamber cavity. The valve also having a second actuation state that establishes fluid communication between the outlet and the first chamber cavity, and separately between the inlet and the second chamber cavity.

Abstract: A portable suction system including a pump device and a removable bag device. The pump device includes a housing defining a recess; a motor assembly positioned within the housing; a first rod at least partially extending from the housing into the recess; and a second rod at least partially extending from the housing into the recess. The first rod and the second rod are driven in response to energization of the motor assembly. The bag device is at least partially positioned within the recess, and the bag device includes: a bag; a vacuum connector; a first piston coupled to the first rod; and a second piston coupled to the second rod.

Abstract: According to an example aspect of the present invention, there is provided a sterile connector for fat harvesting, comprising a body configured to be at least partially inserted into a receptive syringe chamber. The body comprises an external interface end for facing the ambient space and an internal interface end for insertion into the syringe chamber. The connector further comprises a fat input conduit extending through the body. The fat input conduit comprises a coupling for a harvesting tube at the external interface end of the body and a feed port at the internal interface end of the body for feeding the harvested fat into the syringe chamber. The connecter further comprises an air output conduit extending through the body. The air output conduit comprises a coupling for a suction tube at the external interface end of the body and a suction port at the internal interface end of the body for providing a partial vacuum into the syringe chamber.

Abstract: Embodiments of delivering reduced pressure wound therapy are disclosed. In some embodiments, a system includes a reduced pressure wound therapy device and a remote computer. The device can be configured to apply reduced pressure to a wound of a patient according to a default reduced pressure therapy prescription. The device can be configured to monitor usage data and transmit the usage data to the remove computer for determining compliance with a reduced therapy prescription. In some cases, non-compliance can be determined due to change of the prescription from the default prescription to a prescription more suitable for treating the wound. A non-compliance notification can be transmitted to the device. The device settings can be updated to the current prescription.

Abstract: Dressings, systems, and methods for treating a tissue site with negative pressure are described. The dressing includes a manifold having a first surface and a second surface opposite the first surface, a first layer adjacent to the first surface, and a second layer adjacent to the second surface. The first layer and the second layer each are formed from a polymer film. A plurality of fluid restrictions are formed in the polymer film adjacent to at least the first surface. A first plurality of bonds is formed between the first layer and the second layer. The first plurality of bonds define separable sections of the manifold. A second plurality of bonds is formed between the first layer and the second layer. The second plurality of bonds define a plurality of openings.

Abstract: The present disclosure relates to a catheter (1) and a method for manufacturing the catheter (1). The catheter (1) comprises a core tube (10) with a lumen (15) extending from a rear end to a front end along an elongation axis (x), a front portion (13) and a rear portion (11). The catheter (1) further comprises a flexible outer layer (20) forming a fluid reservoir (25, 25?) containing a fluid between the flexible outer layer (20) and at least a part of the front portion (13). The flexible outer layer (20) optionally comprises one or more radial eyelet(s) (23) arranged in front of the front portion (13) of the core tube (10) and being in fluid communication with the front opening (14), wherein the flexible outer layer (20) is more flexible than the core tube (10). Optionally, the catheter (1) further comprises a flexible inner layer (20?).

Abstract: A portable feeding bag holder for an enteral feeding bag is provided. The portable feeding bag holder includes a planar base having upper and lower surfaces. A cradle for receiving an enteral pump is disposed on the upper surface of the base. A frame extends upwardly from the base. A transverse bracket member extends across the frame and is spaced from the base. The bracket member includes a support including at least one receiver for suspending an enteral feeding bag therefrom. A handle is disposed at a distal end of the frame opposite the base. A method of transporting an enteral feeding bag is also provided.

Abstract: IV sets including a plurality of hand pumps and methods of use thereof are described herein. An IV set includes a first portion of tubing, a second portion of tubing, and a drip chamber. The drip chamber includes a spikeless inlet fluidically coupled to the first portion of the tubing, an outlet fluidic ally coupled to the second portion of the tubing, and a curved drop former positioned within the drip chamber between the inlet and the outlet. The curved drop former is configured to receive a fluid via the spikeless inlet and form, based on a curvature of its surface, one or more droplets having a substantially uniform consistency and flowing at a substantially constant rate through the drip chamber.

Abstract: Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.

Abstract: A drug delivery device (1), including a delivery unit (3) comprising a subcutaneous delivery system including a needle support (10), an injection needle (9) mounted on the needle support, and an injection needle actuation mechanism configured to engage and slidably move the needle support from a retracted position where the injection needle is within a housing (2) of the drug delivery device to an extended delivery position where the injection needle projects through a skin contact wall of the housing.

Abstract: Devices, kits and methods described herein are be used at chronic injection site or in conjunction with an indwelling catheter or cannula. A book-like packaging, applicator and/or tensioning device with an opening and optional indicia to align the catheter or cannula to the opening may be used to apply a dressing to a subject. The packaging, applicator and/or tensioning device may apply and/or maintain a strain in an elastic dressing.

Abstract: A self-inflating cuff and methods of using the self-inflating cuff are provided. The self-inflating cuff includes first and second compartments formed within the self-inflating cuff and housing respective substances. The first and second compartments are configured to rupture in response to the force applied to an exterior surface of the self-inflating cuff, which causes the respective substances to combine to initiate a chemical reaction to produce a reactionary force on an interior surface of the self-inflating cuff that causes the self-inflating cuff to expand. The self-inflating cuff is further configured to expand such that a first opening at a first end of the self-inflating cuff and a second opening at a second end opposite the first end of the self-inflating cuff enlarge enough to receive a container through the first opening and a tubing of the container through the second opening.

Abstract: A valve is disclosed that has a body with an inlet, an outlet, and a needleless access port coupled to the body. The access port has an interior space and is configured to be actuated by a needleless connector. The inlet is selectively coupled to the outlet through the interior space such that fluid entering the inlet entirely flows through the interior space to the outlet.

Abstract: An apparatus includes a cannula assembly, a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing includes an inlet port removably coupled to the cannula assembly and defines an inner volume. The fluid reservoir is fluidically coupled to the housing and configured to receive and isolate a volume of bodily fluid from a patient. The flow control mechanism is at least partially disposed in the inner volume. The actuator is operably coupled to the flow control mechanism and is configured to move the flow control mechanism between a first configuration, in which bodily fluid can flow, via a fluid flow path defined by the flow control mechanism, from the cannula assembly, through the inlet port and into the fluid reservoir, to a second configuration, in which the fluid reservoir is fluidically isolated from the cannula assembly.

Abstract: A method may include displaying to a user an interface at which the user inputs a fear of hypoglycemia index (FHI), the FHI corresponding to an acceptable probability of a blood glucose level being below a threshold blood glucose level. The method may also include receiving blood glucose data for a person with diabetes (PWD). The method may additionally include calculating a probability of the PWD having a blood glucose level below the threshold blood glucose level based on the variability of the received blood glucose data. The method may also include setting one or more target blood glucose levels to align the probability of the PWD having a blood glucose level below the threshold blood glucose level with the acceptable probability associated with the user input FHI. The method may additionally include delivering insulin, using the insulin delivery device, based on the target blood glucose level.

Abstract: A method includes receiving up-to-date blood glucose data for a PWD, determining basal insulin dosages for the PWD based on a baseline basal rate, delivering the basal insulin dosages to the PWD, modifying a target blood glucose level based on variability of blood glucose data for the PWD, receiving a temporary override indicating a user preference to reduce the likelihood that the PWD has a hypoglycemic event or a user preference to reduce the likelihood that the PWD has a hyperglycemic event, determining a temporary target blood glucose level based on the input—greater than the modified blood glucose level if the preference is to reduce the likelihood of a hypoglycemic event—lower than the modified target blood glucose level if the preference is to reduce the likelihood that of a hyperglycemic event. The method includes delivering basal insulin for the temporary period of time based on the temporary target.