Abstract: The present application relates to the field of pharmaceutical technology, in particular, to a drug-loaded medical device, including a medical device body and at least one drug coating, the drug coating is attached to at least one side of a surface of the medical device body. The main component of the drug coating includes a macrolide drug. The drug coating includes elongated prismatic crystals each with at least three lateral edges, and/or the drug coating includes crystal clusters of the elongated prismatic crystals each with at least three lateral edges. An aspect ratio of each elongated prismatic crystal is in a range from 1:1 to 40:1.

Abstract: Apparatuses and methods configured to provide heat and cold to the skin along with a skin treatment to control rate of skin treatment flow to the skin are described. The disclosed apparatuses and methods include beneficially delaying the transition of skin treatments once skin penetration is achieved to improve the effectiveness of topical treatments to the skin. Accordingly, the disclosed apparatuses and methods are configured to enhance the benefits of topical treatments to the skin.

Abstract: A cleaning device having a body containing a cleaning fluid, an application member in selective fluid communication with the body via a fluid path, and a first selectively permeably element provided along the fluid path, the first selectively permeable element being configured to selectively interact with one or more selected components of the cleaning fluid sufficient to remove the one or more selected components from the cleaning fluid as the cleaning fluid travels along the fluid path, and wherein selective interaction between the first selectively permeable element and the one or more selected components includes at least a physical interaction. Also disclosed in methods of making and using the cleaning devices described herein.

Abstract: An adapter for use with a tattoo machine is disclosed. The adapter may enable a tattoo machine configured with a wireless battery pack to switch to a wired configuration by removing the wireless battery pack and replacing it with the adapter. One end of the adapter may be affixed to a portion of the tattoo machine so that the adapter may deliver power to the componentry of the tattoo machine to facilitate the operation of the tattoo machine. The other end of the adapter may include a connector for enabling connection of the adapter to a power supply or power source so that power may be delivered from the power supply or power source through the adapter and to the tattoo machine. When the tattoo machine is powered, the motor of the tattoo machine may reciprocate a needle included in a needle cartridge affixed to the tattoo machine.

Abstract: Vascular access assemblies for facilitating hemodialysis of a patient. The vascular access assembly may include a first tubular conduit and a bifurcated stent disposed in the superior vena cava. The vascular access assembly may further include a second tubular conduit that connects that couples an arm of the bifurcated stent to the first tubular conduit to create a blood flow pathway between two locations of a vasculature of a patient.

Abstract: Embodiments disclosed herein are directed to a coupling device including an invertible sleeve transitionable between a first, unlocked configuration and a second, locked configuration. A stem of the coupling device can be urged into a lumen of the catheter. A stem of a port can be urged into a lumen of the coupling device. The sleeve can be inverted from the unlocked configuration, where the sleeve extends distally, to a locked configuration where the sleeve extends proximally. The sleeve can fit tightly about a sleeve bearing portion of the port in the locked configuration to secure the port thereto. The sleeve can be formed of an elastic material to allow the sleeve to transition between the first stable configuration and the second stable configuration. Advantageously, the coupling device forms a continuous outer profile to mitigate tissue ingrowth.

Abstract: An integrated disinfection device is described syringe assembly having two integrated disinfection units assembled to a syringe for disinfecting and sterilizing corresponding medical connectors, specifically access ports of corresponding medical connectors. The integrated disinfection unit includes a first cup and a second cup. The first cup having a chamber containing a first absorbent material, a first disinfectant or an antimicrobial agent in the first cup, and a first peelable seal. The second cup having a chamber containing a second absorbent material, a second disinfectant or an antimicrobial agent in the second cup, and a second peelable seal. A threaded connection is disposed on the bottom exterior surface of the first cup having threads that are sized and pitched to engage threads of a luer lock collar on the distal end of the syringe barrel to allow the first cup to be connected to the syringe assembly.

Abstract: A disinfecting device for a Luer-activated device having a septum is disclosed. The disinfecting device includes a cap, a plunger including a standoff and a face, and a disinfectant. When the Luer-activated device is secured to the disinfecting device, the Luer-activated devices engaged with the standoff but Luer-activated device septum does not contact the standoff or the face.

Abstract: A resealing cap for an intravenous (IV) bag spike port is shown and described. The resealing cap for an intravenous (IV) bag spike port includes a housing having a first end and a second end. the housing has a passageway therethrough. The first end of the housing is a closed end. The closure is created by a puncturable material. The second end of the housing is an open end.

Abstract: A cable system for providing power to an implantable device implanted in a patient having a pedestal base mountable to a skull of a patient. An internal cable extends from the pedestal base and is electrically connectable to the implantable device. An external cable is connectable to the post of the pedestal base. A locking ring is releasably mountable to the post and is movable from a first configuration to a second configuration, wherein in the first configuration the locking ring locks to the post to secure the external cable to the pedestal base and in the second configuration the locking ring releases from the post to release the external cable from the pedestal base.

Abstract: A blood pump comprises a pump casing having a blood flow inlet and a blood flow outlet connected by a passage, and an impeller rotatable about an axis of rotation. A surface of the impeller faces a surface of the pump casing spaced from said surface of the impeller by a clearance, the clearance being in fluid connection with the passage at a clearance transition point. At least one wash out channel extends through the impeller and is in fluid connection with the passage via a first opening and with the clearance via a second opening. The first opening of the wash out channel is arranged in an area of the impeller that is under a higher pressure than the clearance transition point so as to cause a blood flow from the first opening through the wash out channel and the clearance to the clearance transition point.

Abstract: A ventricular connecting assembly and a ventricular assist system. The ventricular connecting assembly comprises a clamping assembly and a locking assembly; the clamping assembly comprises an opening ring, a first connecting arm and a second connecting arm, and the opening ring has a first end and a second end; the first connecting arm) and the second connecting arm are respectively connected to the first end and the second end. The locking assembly comprises a connecting member and a locking member, the connecting member is connected to the second connecting arm, and the locking member is connected to the connecting member; the locking member is rotatably abutted against the first connecting arm, the locking member can adjust the inner diameter of the opening ring during rotation, and the locking member is snap-fitted with the second connecting arm to maintain the opening ring in a clamping state.

Abstract: The present invention relates to a device for regenerating nerve cells and suppressing immune diseases, and more particularly, to a device for regenerating nerve cells and suppressing immune diseases, which uses a contact lens containing a conductive material to increase the effect of microcurrent on nerve cell regeneration and immune response suppression. The device for regenerating nerve cells and suppressing immune diseases comprises: a contact lens comprising a body configured to be worn on a cornea, and a conductive material inserted into the body and serving to induce a microcurrent generated outside the body; a plurality of channels configured to come into close contact with skins around eyes and to generate a flow of microcurrent on upper part of the contact lens; and a signal supply unit configured to supply electrical signals to the plurality of channels.

Abstract: The medical therapy arrangement has a garment tightly arranged at a subject and provided with electrodes at an inner surface of the garment and in electrical contact to a skin of the subject. A connection unit has connection elements electrically connected to the electrodes via separate connection lines being flexible and elastic and integrated into the garment. A connection board has connection pads electrically connected to the control unit that provides each electrode as one of anode, cathode or being disconnected and an integrated part of the garment. The connection board is detachably attachable to the connection unit. The connection unit and the connection board, when attached to each other, are positioned in relation to each other to electrically connected the connection pads to mating connection elements. The connection board and the connection unit have an essentially planar extension and made from a rigid material.

Abstract: The present invention provides an implantable electrode device, a medical device/system thereof, and a diagnostic and/or therapeutic method using the medical device/system. The implantable electrode device includes a flexible non-conductive flap, one or more electrodes integrated with the flap, and one or more wires embedded within the flap and connected to the one or more electrodes. The invention exhibits numerous technical merits such as stable fixation of the electrode to a biological target in a patient.

Abstract: A self-anchoring helical wire structure electrode for energy conduction to or from a tissue target in a body, made of at least one wire rope consisting of biocompatible and conductive wire, and enclosing a hollow core within an inner diameter and having a longitudinal axis, an outer diameter and two ends, being flexible for self-bending in any direction up to 180 degrees on said longitudinal axis, and secured by being capable of self-forming a bunching anchor wider than the insertion channel when injected while its dispenser is substantially stationary.

Abstract: The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which signals are delivered to the vagus nerve in order to stimulate neural activity in the vagal nerve.

Abstract: An electroporation device adapted to perform the following operations: detect the resistance value RA,B between a pair of electrodes placed in a portion of human tissue; calculate, select and store a pair of values of total duration ?(n,t) and voltage V that satisfy the inequality: ? · [ ( V / d ) ] 2 · ? ? ( n , t ) ? > A ? D R where: ADR represents the energy dose that realises a reversible electroporation—the energy dose ADR is a known value stored in the device; ? is defined as the inverse of resistivity ?=1/; d is the spacing of the electrodes; the resistivity =R*S/d where R denotes the measured and stored resistance value and S the section of the electrodes; and control a power amplifier so that a voltage equal to the voltage V is applied to the electrodes and supplied to the tissue portion for the determined total duration ?.

Abstract: Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI), a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.

Abstract: Systems, devices and methods are provided for transcutaneously delivering energy impulses to bodily tissues for therapeutic purposes, such as for enhancing the body's bone healing process in spinal fusion patients. A therapeutic stimulator system comprises a housing for an energy source and a signal generator. The system further includes one or more electrodes coupled to the signal generator. A processor is coupled to the housing and configured to determine usage levels of the signal generator and/or motion data of the housing. The system may include a mobile device that allows the patient to input user status data, such as pain levels, and compare the user status data with the usage levels and/or the motion data, thereby improving patient compliance with a prescribed therapy regimen.

Abstract: The present disclosure relates to neuromodulation, and in particular to devices and techniques for delivering non-invasive neurostimulation to treat enuresis. Particularly, aspects of the present disclosure are directed to medical device comprising a transcutaneous electrical nerve stimulation (TENS) device comprising an electronics module comprising: a controller configured to provide a set of stimulation parameters, and a pulse generator configured to generate neural stimulation based on the set of stimulation parameters. The medical device also includes one or more electrodes connected to the TENS device for delivering the neural stimulation generated by the pulse generator to a perineal region of a user, one or more gel pads for adhering the electrodes to the perineal region of the user, one or more sensors for detecting a triggering event for the neural stimulation, and a pad attached to the TENS device, the electrodes, the sensors, and the gel pads.

Abstract: Systems, devices, and methods for neurostimulation via vestibular stimulation are described. One example is a device for administering thermal stimulation to an ear canal of a subject. The device may include an earpiece configured to be at least partially insertable into the ear canal of the subject; a thermoelectric device thermally coupled to the earpiece and configured to heat and/or cool the earpiece to thereby heat and/or cool the ear canal of the subject; and a controller configured to administer a selected treatment plan including administering a caloric vestibular stimulation (CVS) stimulus to the ear canal of the subject in a condition-treatment effective amount during a first treatment interval. The treatment plan may be effective to produce a durable improvement in at least one symptom of the condition for a time of at least 1 week following cessation of the administering.

Abstract: A computer-implemented method is provided for modifying a stimulation artefact in a measured electrical response of a subject to a stimulus. The method comprises: i) providing a first and a second signal. The first signal is a signal used as stimulus or a time-dependent signal derived from the stimulus and the second signal is a signal obtained as the measured electrical response to the stimulus; ii) determining a stimulus-response mapping between the first signal and the second signal; iii) identifying a feature of the determined stimulus-response mapping corresponding to the stimulation artefact; iv) determining a predicted electrical response corresponding to the identified feature of the determined stimulus-response mapping; and v) subtracting the predicted electrical response from the second signal to obtain a stimulation artefact modified measured electrical response.

Abstract: Illustrative methods and devices for providing stimulus to the eye to treat vision disorders. Systems and methods for testing thresholds and configuring the stimulation for a patient are provided. Various examples may include therapies for vision disorders that can progress to blindness, such as macular degeneration or other diseases and disease processes.

Abstract: A system for performing spinal cord stimulation on a subject is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be minimally invasively inserted to a target stimulation site within the nervous tissue, includes stimulation electrodes. The processor is configured to receive more recorded signals from the recording arrays at the target recording site, determine an electrophysiological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the determined electrophysiological state in order to affect the electrophysiological state.

Abstract: The cure for Bell's palsy and Ramsay Hunt syndrome comprised individual series of electrical stimulus for relieving the compression of ipsilateral facial nerve in its facial canal. The compositions of selfies and related avatars of patients recommending frequencies, durations and numbers of individual treatment sessions for achieving full recovery and digital blockchains managing the cure among patients.

Abstract: Systems, devices, and methods are disclosed for computer-assisted goal setting and tracking with respect to neuromodulation device treatment. A digital health system includes a user-interface device to receive a user input about a personalized objective of neuromodulation treatment or an intended manner of using the neuromodulation device by the patient. The user input can be in forms of text, voice, or other unstructured or unclassified data formats. A controller circuit can process the user input using analytical methods including natural language processing to generate a personalized treatment and device usage goal, and track the progress toward the personalized treatment and device usage goal using patient state information. The tracked progress may be presented to the patient, or be used to initiate or adjust a neuromodulation therapy.

Abstract: A system is provided for informing a therapeutic procedure. In some embodiments, the system may be configured to determine specific states associated with a sleep-wake cycle of a patient. Additionally, the system may be configured to measure one or more signals with cardiac activity of the patient upon detecting the specific states of the sleep-wake cycle of the patient. Subsequently, the system may be configured to determine one or more parameters for applying an electrical signal to an anatomical element of the patient based on the one or more signals with cardiac activity. In some embodiments, the system may be configured to establish a longitudinal trend of cardiac metrics for the patient based on a plurality of signals with cardiac activity for the patient measured during the specific states of the sleep-wake cycle across a plurality of days.

Abstract: A flexible electrode array with hundreds or thousands channels for clinical use includes an array of at least hundreds of electrodes on a flexible biocompatible polymer substrate. Perfusion through holes are provided through the substrate. Individual elongate leads connect to each of the electrodes, the elongate lead connections being supported by the flexible biocompatible polymer substrate and extending away from the array. Flexible biocompatible polymer insulates the individual elongate lead connections and supporting the array. An interposer with individual channel connections is conductively bonded to the individual elongate lead connections. Sterile bag packaging encloses a portion of the interposer, where the outer side of the package including the array and individual elongate lead is sterile while the inner side of the packaging is non-sterile. The portion interposer inside the package is configured to connect to a circuit board within the packaging.

Abstract: Systems and methods for generating and/or applying an adjustment for one or more parameters of a neuromodulation therapy of a user are provided. One or more physiological-based inputs of the user may be received and a therapy response score may be determined based on the one or more physiological-based inputs. At least one adjustment for one or more parameters of the neuromodulation therapy may be generated based on the therapy response score.

Abstract: The disclosure provides systems and methods for treating sleep-disordered breathing (e.g., obstructive sleep apnea) using a system comprising an inertial measurement unit (IMU) which includes an accelerometer and/or a gyroscope, wherein the IMU is configured to detect movement by a human subject and to generate data based on the detected movement. Positional and/or movement data generated by the IMU is used by a stimulation system to detect gross movement by the subject, and to deliver electrical stimulation to a nerve which innervates an upper airway muscle (e.g., a hypoglossal nerve) in response to the detection of gross movement, in order to treat the subject.

Abstract: A system for performing deep brain stimulation on a brain of a patient is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be inserted to a target stimulation site within the deep brain, includes at least one stimulation electrode. The processor is configured to receive one or more recorded signals from the recording arrays at the target recording site, determine a neurological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the neurological state in order to electrically stimulate the brain.

Abstract: Devices, systems, or methods include generating, by stimulation generation circuitry, a first train of electrical stimulation pulses at a first frequency to a first target tissue; and generating, by the stimulation generation circuitry, a second train of electrical stimulation pulses at a second frequency to a second target tissue different from the first target tissue, wherein at least some electrical stimulation pulses of the first train of electrical stimulation pulses are interleaved with at least some electrical stimulation pulses of the second tram of electrical stimulation pulses. At least the first target tissue is associated with a spinal cord of a patient, and the second target tissue is associated with at least one of a peripheral nerve or a nerve root of the patient.

Abstract: Devices, systems, and techniques are described for selecting parameters for electrical stimulation therapy. For example, device may include processing circuitry configured to determine a first window of time to sense a physiological signal, determine, based on the first window of time, a second window of time for delivering electrical stimulations, and determine, based on a duration of the second window of time, a number of stimulation pulses deliverable during the second window of time at one or more pulse frequencies. The processing circuitry may then output, based on the number of stimulation pulses deliverable during the second window of time, at least one selectable stimulation parameter that at least partially defines the electrical stimulation, wherein the second window of time is adjacent to the first window of time.

Abstract: A system is provided for identifying and reducing noise in a therapeutic procedure. For example, the system may be configured to measure one or more signals with cardiac activity. The system may be configured to then identify one or more sources of noise that are distorting the one or more signals with cardiac activity and may reduce the one or more sources of noise from the one or more signals with cardiac activity. Subsequently, the system may be configured to determine one or more aggregate cardiac-derived metrics and/or save processed cardiac data based on the one or more signals with cardiac activity with the one or more sources of noise reduced. Additionally, the system may be configured to determine one or more parameters for applying an electrical signal to an anatomical element of a patient based on the one or more aggregate cardiac-derived metrics and/or saved processed cardiac data.

Abstract: A subcutaneously implantable device includes a housing, a first anchoring arm attached to the housing that is configured to anchor the device to a muscle, a bone, and/or a first tissue, and a first prong with a proximal end attached to the housing and a distal end extending away from the housing that is configured to be positioned adjacent to or contact an organ, a nerve, or a second tissue. A first electrode is on the distal end of the first prong that is configured to contact the organ, the nerve, and/or the second tissue. Circuitry in the housing is in electrical communication with the first electrode and is configured to sense an electrical signal from the organ, the nerve, and/or the second tissue through the first electrode, and/or deliver electrical stimulation to the organ, the nerve, and/or the second tissue through the first electrode.

Abstract: An active implantable medical device (AIMD) assembly has a medical device housing containing an electrical power source connected to control circuitry, and a header assembly connected to the device housing. The header assembly supports a plurality of co-axially aligned terminal blocks that are in open communication with a header opening. A conventional strain relief member is connected to the header assembly at the header opening. A number of different auxiliary strain relief devices are described. The auxiliary strain relief devices connect to the conventional strain relief member to help reduce tension and stress on a lead after the AIMD assembly is implanted in a body and the lead electrodes are connected to body tissue.

Abstract: In one example, a lead comprises a plurality of conductors, each conductor of the plurality of conductors comprising a conductor first end, a conductor second end, and a conductor intermediate portion therebetween, and a spline. The lead may include a first set of contacts and a second set of contracts electrically coupled with respective conductors of the plurality of conductors. The second set of contacts may include a plurality of inserts defining a plurality of apertures through which an end of respective conductors is disposed. Tire lead may further include an outer lead body disposed over at least the intermediate portion of the plurality of conductors.

Abstract: In embodiments, a wearable cardioverter defibrillator (WCD) system includes electrodes that render an ECG signal of the patient, and a processor that receives ECG data are derived from the rendered ECG signal. The processor may filter the received ECG data with a matched difference filter to detect QRS complexes, and compute a heart rate from the detected QRS complexes. The matched difference filter itself can have coefficient values associated with a baseline QRS complex, which improves detection.

Abstract: Disclosed are a multi-pole radio frequency (RF) device, a method for controlling multi-pole RF device, and an RF therapeutic apparatus. The multi-pole RF device includes an RF power supply, a return electrode, a therapeutic electrode, a controller, a first switch switching circuit, and/or a second switch switching circuit. The controller controls the third input terminal and the fourth input terminal of the second switch switching circuit to be switchably connected to the third output terminal and the fourth output terminal. In the unipolar mode, the controller controls the first output terminal and the second output terminal to be electrically connected to the therapeutic electrode and the return electrode respectively. In the bipolar mode, the controller controls the first output terminal and the second output terminal to be connected to at least one of the plurality of electrode slices respectively.

Abstract: A method includes generating, from an electronic 3-dimensional map indicating placement locations of a plurality of electrode arrays, an electronic 2-dimensional map indicating placement locations of the plurality of electrode arrays relative to each other in 2-dimensional space. The electronic 3-dimensional map is associated with a surface area of at least a portion of a body of a patient. The electronic 3-dimensional map indicating the placement locations of the plurality of electrode arrays can be generated based on at least one medical image.

Abstract: An apparatus (1) for treating a cancerous target site is provided. The apparatus comprises an electromagnetic emitter (10) comprising one or more electrodes with an electrically insulating coating for preventing electrical contact between the electrodes and the target site. The electromagnetic emitter (10) is configured to provide a tumour treating field at a target site (30) via the one or more electrodes, the tumour treating field being non-ionizing alternating electromagnetic field having a frequency of between 10 kHz to 300 kHz; and further having a magnetic flux density of between 0.1 pT and 1 mT. The apparatus further comprises a heat source (20) configured to provide heating at the target site to cause hyperthermia at the target site. The apparatus is configured to apply the non-ionizing alternating electromagnetic field and the heating independently. The apparatus comprises an electronic controller for electronically controlling the electromagnetic emitter and the heat source.

Abstract: An apparatus and method may be provided utilizing electropermanent magnets (EPMs) to deliver either or both ultrasound and changing magnetic fields. The apparatus and method may be used to modulate neurons and/or transport materials in the nervous system of human or non-human animals.

Abstract: According to some embodiments, a system for fractionally treating tissue includes: an electromagnetic radiation (EMR) source configured to generate an EMR beam having a transverse ring energy profile; an optic configured to converge the EMR beam to a focal region located within a tissue; and, a window assembly located down-beam from the optic configured to cool the tissue when placed in contact with an outer surface of the tissue.

Abstract: A phototherapy device is provided for treating a medical condition by delivering phototherapy using a pad and a light source supported by the pad. The light source includes multiple light emitters that are located at different positions on the pad and that emit treatment electromagnetic radiation. A treatment property of the phototherapy varies spatially based on medical properties of the anatomical treatment area.

Abstract: A method of inducing death or inhibiting growth or reproduction of a Gram-positive bacterial cell involves contacting the bacterial cell with a coproporphyrinogen oxidase (CgoX) activator, thereby promoting accumulation of coproporphyrin III (CPIII) in the bacterial cell, where the CPIII serves as an intracellular photosensitizer; contacting the bacterial cell with a photosensitizer conjugated to an iron-regulated surface determinant (Isd) protein targeting moiety, which Isd proteins are expressed on the service of the bacterial cell such that the conjugated photosensitizer serves as an extracellular photo sensitizer; exposing the bacterial cell to light having a first excitation wavelength of the intracellular photo sensitizer; and exposing the bacterial cell to light having a second excitation wavelength of the extracellular photosensitizer.

Abstract: The present disclosure discloses an automated particle implantation system comprising an active system and a passive system. The active system may be configured to obtain a scanning image of a scanned object. The active system may be also configured to plan a radioactive particle implantation treatment according to the scanning image and obtain a radioactive particle implantation treatment planning result. The active system may be further configured to control the passive system to execute a radioactive particle implantation operation based on the radioactive particle implantation treatment planning result. The present disclosure further discloses a particle chain generating mechanism. The present disclosure further discloses a puncture device terminal.

Abstract: Disclosed herein are methods for personalized treatment of individual patient tumors. A computer software configured to integrate with a radiation therapy treatment planning system is presented. The computer software is configured to: assign a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor; calculate a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI; and provide, to the radiation therapy treatment planning system, the recommended RxRSI as a radiation therapy dose for a radiation plan.

Abstract: A phantom for quality assurance for stereotactic body radiation therapy, systems and methods are provided. In some embodiments, a phantom has a body including a peripheral ring potion defining a ring shaped peripheral film holder and a center portion defining a central axis film holder for receiving a radiochromic film.

Abstract: Disclosed herein are systems and methods for proton radiation therapy treatment planning that perform deformable image reconstruction and relative stopping power (RSP) maps updating using individual proton measurement data without requiring use of an entire proton radiography image. The systems and methods are capable of using protons from an arbitrary set of angles and/or positions. The iterative method optimally fits protons, while minimizing deviations from the original or deformed RSP map. The systems and methods use a covariance matrix to account for different uncertainties. Each iteration correctly accounts for in the proton data from measurement uncertainties, optimizing the overall fit of the RSP map to the proton data even though each proton does not fit perfectly due to measurement uncertainties. Different weights for the deviations from the original or deformed RSP map may be assigned to different voxels. The different weights may account for correlations in the deviations between voxels.