Abstract: The invention discloses a treatment composition to treat nasal or oral dryness and allergy symptoms, and a method for using the same. Certain compositions include xylitol, at least two wetting agents, an aqueous carrier, and other active ingredients, such as a potassium salt, a sodium salt, and a preservative. The composition may be configured as a nasal or oral spray, and oral rinse, or a nasal gel.

Abstract: The present invention relates to potassium hydrogen alkylhydroxamate compounds and compositions and formulations comprising same, processes for preparing the inventive potassium hydrogen alkylhydroxamate compounds, as well as applications thereof including the use of the inventive compounds and compositions in formulations of products or components of products.

Abstract: The present disclosure relates to the field of perfumery and more precisely it concerns a deodorant or an antiperspirant composition comprising a ?-thio carbonyl profragrance. The use of the composition to reduce body odour and a dispensing container comprising the composition are also objects of the disclosure.

Abstract: Suggested is a mixture comprising or consisting of: (a) a protein extract obtained from cereal gluten extracted by means of aqueous ethanol, said extract being characterized by a content of at least 50 wt.-% proteins having a molecular weight of at least 22 kDa; (b) at least one organic acid; and (c) at least one cosmetically acceptable carrier.

Abstract: A composition contains a cell culture medium and, as an active ingredient, albumin, hyaluronic acid or collagen. The composition is useful as a cosmetic or pharmaceutical purpose for alleviating, preventing or treating skin wounds, skin diseases or skin conditions, by enhancing recovery capability of cells. The cell culture medium may be a serum-free medium.

Abstract: A subject matter of the present invention is a process for the treatment of keratin fibers, such as the hair, comprising the application, to the keratin fibers, of a composition comprising at least one alkoxysilane chosen from the compounds of formula (I), at least one non amino silicone of formula (II), the non amino silicone(s) of formula (II) having a weight-average molecular weight of less than or equal to 1500 g/mol and at least one coloring agent chosen from pigments, direct dyes and their mixtures, followed by a stage of application of heat to the keratin fibers covered with the composition, using a heating tool, at a temperature of greater than or equal to 45° C. for a period of time of greater than or equal to 15 minutes.

Abstract: Compositions are provided which include at last one Dead Sea extract and at least one polysaccharide, wherein the repeating unit of said polysaccharide is a tetrasaccharide consisting of two D-glucose residues, one L-fucose residue and one D-glucuronic acid residue. Formulations include the compositions which are used as skin protectants against pollution.

Abstract: Disclosed are nano/micromotor devices, systems, and methods for providing payloads in the gastrointestinal system. In one aspect, a micromotor for a gastrointestinal tract includes a micromotor body including a one or more material layers to provide a structure that surrounds a hollow interior region and has an opening to an exterior of the micromotor body; one or more particles including a biocompatible metal element, the one or more particles contained in the interior region of the micromotor body; a coating coupled to the structure of the micromotor body; and a payload material, in which the micromotor is structured to move in a fluid of a gastrointestinal system based on a reaction between the one or more particles and a constituent or a condition of the fluid, such that the reaction generates bubbles that accelerate out of the opening of the micromotor body to propel the micromotor in the fluid.

Abstract: The invention is in the field of delivery of transgenes to target cells using viral vectors, particularly in the field of gene therapy. Compositions have been identified which allow for oral administration of viral particles, particularly adenoviral particles.

Abstract: The present invention relates generally to a methods and apparatuses for treating ear pain and clearing excess fluid from Eustachian tubes.

Abstract: Disclosed in the present invention are an edaravone pharmaceutical composition and an application thereof as a sublingual preparation, the pharmaceutical composition containing edaravone or a salt thereof and mannitol. A sublingual administration preparation can avoid the first-pass effect of the liver, and samples feature good stability, convenience of transport and of use, among other advantages.

Abstract: Methods of preparing monodisperse oligomer reagent compositions such as oligo(ethylene glycol) reagent compositions are described herein. The methods involve reacting a halo-terminated oligomer such as an oligo(ethylene oxide) having (m) monomers with a hydroxyl-terminated oligomer such as a hydroxyl-terminated oligo(ethylene oxide) having (n) monomers.

Abstract: The present invention relates to a method of obtaining a novel gelling agent. Said method comprises adding ethylcellulose, to a mixture of propyleneglycol laurate and propyleneglycol isostearate at a temperature of between 90° C. and 110° C. The method according to the invention provides a simpler, less energy consuming, cheaper and easier way of obtaining a substantially gelling agent which can be used for manufacturing an oleogel and/or a bigel, for cosmetic and/or pharmaceutical use.

Abstract: The present invention provides, among other things, methods and compositions for effective delivery of messenger RNA (mRNA) to the central system (CNS). In particular, the present invention provides methods and compositions for administering intrathecally to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome, such that the administering of the composition results in the intracellular delivery of mRNA in neurons in the brain and/or spinal cord. The present invention is particularly useful for the treatment of CNS diseases, disorders or conditions, such as spinal muscular atrophy.

Abstract: A free-flowing solid pharmaceutical formulation comprising one or more active ingredients and a blend comprising sorbitol and liquid paraffin, a package containing the formulation, a process for the manufacture of the formulation and the use of the blend in the formulation.

Abstract: The present invention relates to a lyophilizate comprising at least one globin, one globin protomer or one extracellular hemoglobin of annelids, and a stabilizer chosen from disaccharides, polyols and antioxidants. The present invention also relates to a composition comprising: a solution comprising at least one globin, one globin protomer or one extracellular hemoglobin of annelids, and a stabilizer chosen from disaccharides, polyols and antioxidants. Finally, the present invention relates to a process for preparing the lyophilizate.

Abstract: The present description relates to a method for extracting at least one substance of interest, the method comprising the following steps: —providing an admixture comprising water, a source comprising the at least one substance of interest or at least one precursor thereof, at least one surfactant and at least one lipophilic compound; —the emulsification of the admixture, leading to the formation of an emulsion; wherein the emulsion comprises: —a continuous aqueous phase; and a discontinuous lipidic phase comprising the at least one lipophilic compound, the at least one surfactant and at least one substance of interest extracted from the source during the emulsification; wherein the method further comprises the addition of at least one cryoprotectant to the admixture and the lyophilization of the emulsion.

Abstract: The disclosure provides a method for delivering an agent to posterior segment of an eye comprising administrating a pharmaceutical composition comprising the agent and mesoporous silica nanoparticles to the eye. An eye drop and a method for treating an ocular disease in a subject in need of such treatment are also provided.

Abstract: A sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet including a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.

Abstract: A hand sanitizing device described herein allows users to sanitize and/or disinfect their hands by bathing them in ultraviolet light. The hand sanitizing device may comprise a cabinet that comprises one or more cavities for a user's hands. The one or more cavities may comprise a sensor to detect a user's hands, a controller to send signals to a plurality of ultraviolet lights, and a plurality of ultraviolet lights. Based on a determination that the user has placed their hands in the one or more cavities, the plurality of ultraviolet lights may be illuminated to sanitize and/or disinfectant the user's hands. When the user has removed their hands from the one or more cavities, the plurality of ultraviolet lights may be turned off. By using ultraviolet light, the hand sanitizing device may reduce the spread of infectious diseases and waste consumption associated with bathroom usage.

Abstract: Hand held and portable disinfection units for use with patients having indwelling catheters or are hospitalized or under care in an intensive care unit.

Abstract: In one embodiment of the present invention, there is an ultraviolet equipped smart hair appliance organizer (“organizer”) that can be mounted on a wall or taken off the wall and closed with a lid for portability. Both the lid and a front plate contain sanitization and disinfecting lights that shine ultraviolet light on hair appliances. The organizer has coiled cords connecting the hair appliances. The organizer utilizes lasers in order to detect the presence of hair appliances within the organizer; automatically shut off the hair appliances after a preset time period of the hair appliances being inside the organizer; automatically turn on ultraviolet lights for the purpose of sanitization and disinfection of the hair appliances inside the organizer as soon as the organizer is closed; and automatically shut off the ultraviolet lights after a preset time period.

Abstract: Freshening composition having at least 85% by weight of the freshening composition of water; at least 0.0015% of by weight of the freshening composition of alkoxylated phenol; and a perfume having at least 60% by weight of the perfume, Perfume Raw Materials having ClogP greater than 1.0. The alkoxylated phenol is according to Formula (I): wherein a is a value selected from 3 to 15; b is a value selected from 0 to 12; wherein the value of a+b, the degree of alkoxylation is from 3 to 15.

Abstract: A sterilization system includes a communication hub that is configured to transfer information between devices of the system such as a sterilizing cabinet, biological indicator analyzer, and a server in order to allow a user to track a medical device throughout a sterilization process. The server may provide data to the sterilizing cabinet during a sterilization process that may be used to verify that the medical device is compatible with the sterilizing cabinet, and to automatically select a compatible sterilization cycle to perform on the medical device. Automatic selection of sterilization cycles and confirmation of compatibility reduces the possibility for user error, which could result in contaminated medical devices being placed back into service. Automatic selection of sterilization cycles also allows users to more efficiently configure and perform sterilization cycles while being confident that the medical device will be sterile upon completion.

Abstract: The present invention relates to an automatic medical device cleaning agent supply device, comprising a case, peristaltic pump unit, timer unit, foot switch, and controller, that automatically supplies the cleaning solution into the cleaning tank to clean medical devices in an amount relative to the amount of water in the cleaning tank when the foot switch is pressed and wherein an attachment housing is secured on a fixed housing in the peristaltic pump unit in a detachable manner for the attachment housing to be selectively detached to facilitate tube replacement and use, through which the tube, which is a consumable, can be replaced conveniently to ensure the ease of maintenance of the device.

Abstract: A sterilization container with a sensor module for monitoring the environmental characteristics internal to the container. The sensor module includes a normally closed end bore. A sensor is disposed in the closed end void space. Other sensors also part of the module monitor the pressure and temperature of the environment inside the container. Based on the measurements of the environment in the container and the environment within the closed end void space it is possible to determine the extent to which the container is filled with saturated steam.

Abstract: A sanitation management system maintains records of exemplary locations on an item to be sanitized and indicates those locations to a person or system charged with applying a pathogen surrogate prior to a sanitation process. The sanitation management system maintains records of where the pathogen surrogate was applied prior to the sanitation process. Following the sanitation process, the sanitation management system indicates to an inspector, or an inspection system, locations of where the pathogen surrogate was applied for the purpose of facilitating testing of the sanitation process by checking for the presence of the pathogen surrogate at some or all of those locations. This can ensure that the inspection process is relevant to the sanitation process and less likely to generate false negatives where the inspection finds a lack of the pathogen surrogate not due to cleaning, but due to lack of application of the pathogen surrogate.

Abstract: The invention relates to biocompatible polymer gel compositions useful in facilitating and maintaining hemostasis. The biocompatible polymeric gel composition is comprised of (a) one or more than one polyanionic polymer, (b) one or more than one polycationic polymer, and (c) a solvent. A preferred composition includes sodium alginate, chitosan, and water to produce an adhesive hemostatic device that is useful in facilitating and maintaining rapid hemostasis.

Abstract: Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.

Abstract: A technique can consistently achieve thicknesses of ?50 ?m for corneal tissue for for Descemet stripping automated endothelial keratoplasty (DSAEK). Grafts with thicknesses of ?50 ?m are also known as nanothin DSAEK (NT-DSAEK) grafts. Evidence shows that using thinner DSAEK grafts, particularly NT-DSAEK grafts, can significantly improve visual outcomes. According to an example embodiment, a method for producing a corneal graft includes drying a donor cornea to cause a pre-cut thickness of the donor cornea to decrease. The method includes, concurrently with drying the donor cornea, determining pre-cut thickness measurements for the donor cornea. The method includes, in response to the precut thickness measurements indicating the pre-cut thickness of the donor cornea has decreased to a predetermined value, cutting the donor cornea to a post-cut thickness of ?100 ?m, or more particularly ?50 ?m, to produce a corneal graft.

Abstract: Systems and methods for tissue engineered synthetic support structures, such as grafts and patches are provided. The systems and methods can be used to make tissue engineered planar sheathes or meshes that can be fashioned into substantially planar or non-planar 3D tissue/organ structures adaptable to structure and organs within a human or mammalian body. The systems and methods can use bioink deposited on a material having specified properties and matured under specified conditions to create the tissue engineered planar sheathes or meshes having biomechanical and biological properties tailored to a particular tissue.

Abstract: The apparatuses and methods described herein relates generally to the field of active agent (drug) release from surgical grafts useful for soft tissue reconstruction, regeneration, or repair. More particularly, described herein are surgical grafts for soft tissue repair that include an active agent that is released over time while advantageously matching the biomechanical properties of tissue during healing and recovery.

Abstract: Methods, systems, and devices for enhancing cancer immunotherapy featuring co-transplantation of encapsulated xenogeneic cells with separately encapsulated autologous or allogeneic cells, e.g., autologous or allogeneic tumor cells. For example, both a first cellular transplantation device housing a patient's own tumor cells and a second cellular transplantation device housing xenogeneic cells may be implanted into a patient. The presence of the xenogeneic cells elicits an enhanced immune response, e.g., the xenogeneic cells will draw in a large number of immune cells. Shed tumor antigens from the first cellular transplantation may then be taken up by the immune cells that were drawn to the xenogeneic cells. This will generate an anti-tumor immune response that is amplified relative to a response elicited by the encapsulated tumor cells alone.

Abstract: Embodiments of the present disclosure provide for treated articles of tubing having anti-fouling characteristics, methods of making treated articles of tubing, and the like. Disclosed herein are treated articles of tubing impregnated with a silicone oil and a nitric oxide release agent. Also described are methods for preparing a treated article of tubing and methods for delivering a pharmaceutically acceptable fluid to a subject in need thereof, wherein the fluid is transferred from a fluid source through treated articles of tubing to the subject.

Abstract: An implantable device including a metal substrate; that contains particles having a size of 1 ?m or more; if the wall thickness of the metal substrate is greater than or equal to 0.04 mm and less than or equal to 0.12 mm, the largest particle size is less than or equal to 15 ?m and the average content of the particles is less than or equal to 40 ppm; if the wall thickness of the metal substrate is greater than 0.12 mm and less than or equal to 0.2 mm, the largest particle size is less than or equal to 20 ?m and the average content of the particles is less than or equal to 100 ppm; The size of the particles and the average content of the particles are reasonably controlled according to the wall thickness of the metal substrate, improving the plastic deformation capability of the implantable device.

Abstract: Provided herein are submucosal lifting compositions and methods of using same. The submucosal lifting agents of the disclosure include a polysaccharide, a polyol, and a colorant.

Abstract: The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 ?m in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.

Abstract: According to the invention there is provided inter alia a process for the manufacture of a solid object having a surface comprising a layered coating of cationic and anionic polymer wherein the outer coating layer comprises an anticoagulant entity, comprising the steps of: i) treating a surface of the solid object with a cationic polymer; ii) treating the surface with an anionic polymer; iii) optionally repeating steps i) and ii) one or more times; iv) treating the surface with a cationic polymer; and v) treating the outermost layer of cationic polymer with an anticoagulant entity, thereby to covalently attach the anticoagulant entity to the outermost layer of cationic polymer; wherein, the anionic polymer is characterized by having (a) a total molecular weight of 650 kDa-10,000 kDa; and (b) a solution charge density of >4 ?eq/g; and wherein, step ii) is carried out at a salt concentration of 0.25 M-5.0 M.

Abstract: A method is disclosed for producing an artificial lung including a plurality of porous hollow fiber membranes for gas exchange which have an outer surface, an inner surface forming a lumen, and an opening portion communicating the outer surface with the inner surface. The method includes bringing any of the outer surface and the inner surface into contact with a colloidal solution that contains an antithrombotic high-molecular compound to circulate carbon dioxide gas to a side of the other surface. According to the present disclosure, an artificial lung can be produced in which a coating amount of antithrombotic high-polymer material (an antithrombotic high-molecular compound) on a hollow fiber membrane is increased.

Abstract: An embodiment of the present disclosure may include a base for a scent warmer. The base may include a base member and a stem extending upwardly from the base member. The stem may be configured to carry a heating element thereon. The base may also include an elastomeric sleeve surrounding at least a portion of the stem. The elastomeric sleeve may be configured to apply a retention force between a removable decorative body and the stem. The elastomeric sleeve may include a wall member sized and configured to abut against the stem and a plurality of ribs extending radially outward from the wall member.

Abstract: A diffuser that may receive a refill bottle that supplies fragrance to the diffuser is provided. The diffuser includes a seat to facilitate easy placement and alignment of the refill bottle in the diffuser. The diffuser has an arm that can rotate about a pivot axis. The arm may rotate away from the seat to allow the user to place the refill bottle into the seat of the diffuser. The arm may also rotate towards the seat such that the arm can be placed over the refill bottle. The arm contains a piezo-electric component that can atomize the fragrance supplied by the refill bottle. The arm also includes a plurality of springs to create sufficient contact between the piezo and the refill bottle, to apply a downward force on the refill bottle, and to engage with a lock to secure the arm over the refill bottle.

Abstract: A filter and a filter system including the filter. The filter includes a porous filter frame having a first upstream-side surface, and a second downstream-side surface based on a thickness direction, the porous filter frame filtering particulate matter. A copper material layer is disposed on at least a portion of the first upstream-side surface of the filter frame.

Abstract: A ceiling, wall- or surface-mounted light fixture with a housing containing one or more external visible light sources to illuminate the space where the light fixture is mounted, one or more emitters inside or outside the housing to destroy bacteria, viruses, and pathogens in area inside or outside the housing, and one or more fans inside the housing that recirculate the air in a space and subject the air to bacteria, viruses, and pathogen-destroying influence inside the housing, destroying bacteria, viruses, and pathogens in the air passing though the housing.

Abstract: The present invention provides a negative pressure generator such as a suction cup, the negative pressure generator comprising a negative pressure transmitter with a shape that remains constant after deformation so that no part of the negative pressure transmitter comes into contact with another member of the negative pressure generator. The negative pressure transmitter (80) includes an opening (81), a closed bottom portion (83), and an intermediate portion (82) connecting the opening to the bottom portion, wherein the intermediate portion includes at least a plurality of rigid portions (84a) that are formed at predetermined intervals so as to inhibit deformation, and flexible portions (86a) that are formed between the plurality of rigid portions and formed from a flexible material.

Abstract: A wearable breastmilk collection device includes a storage compartment with a flange and a cup, a breast accepting flange separated from the storage compartment by a one-way valve, a vacuum source attachment, and a reservoir in communication with the vacuum source attachment. A method of expressing and collecting breastmilk from a breast may involve using the wearable breastmilk collection device described above to express breastmilk from the breast, while the device is positioned in the woman's brassiere.

Abstract: A blood purification apparatus includes: a peristaltic pump that includes a stator to which a pump tube including a first portion and a second portion is detachably attached, and a rotor including a roller and a guide portion, the roller delivering liquid by squeezing the pump tube, the guide portion retaining the pump tube so that the pump tube is squeezable with the roller about a predetermined axis; an anchor member that anchors an attaching member to which the pump tube is attached; and a displacing portion that displaces the attaching member between a set position and an unset position by moving the anchor member with the attaching member being anchored by the anchor member.

Abstract: Dialysis systems and methods for operating dialysis machines (e.g., peritoneal dialysis machines) for conducting dialysis treatments are disclosed. The dialysis system may include a dialysis machine for transferring dialysate to a patient from a dialysate source. The dialysate may flow from the dialysate source through a cartridge or cassette (e.g., a disposable cartridge or cassette) positionable within the dialysis machine. The cassette includes a fluid flow channel. The dialysis machine includes a heating chamber for in-line heating of the dialysate in the fluid flow channel. The fluid flow channel is arranged and configured to provide turbulent flow of the dialysate through the fluid flow channel to provide increased heat transfer from the heating chamber to the dialysate.

Abstract: A device for mass transfer between blood and at least one gas/gas mixture, includes first and second chambers through which blood is able to flow and in each of which a respective plurality of mass-permeable hollow fibers are disposed around a respective axially extending core element, wherein a gas/gas mixture is able to flow through, and blood is able to flow around, the hollow fibers, wherein the second chamber follows the first chamber in the blood flow direction, wherein the first and second chambers are disposed next to one another, and in particular disposed spaced apart between the core element center axes thereof, and the two chambers have a connection in an axial end region by which the chamber volumes through which blood is able to flow are connected, and in particular are connected in the direction of the spacing.

Abstract: According to the present invention, blood access formed by a percutaneous terminal for hemodialysis is performed, the percutaneous terminal provided with: a contact body comprising a biocompatible member that comes into contact with skin tissue inside and outside a living body; a tubular body having one end connected to an artery and the other end connected to a vein; a blood removal tubular body having one end connected to a side surface of the tubular body and supplying blood to an external blood circuit; and a retransfusing tubular body having one end connected to the vein and the other end connected to a retransfusing portion of the blood circuit, wherein the other end of the blood removal tubular body and the retransfusing tubular body are located at a central portion of the contact body. Furthermore, provided is a hemodialysis system that is less burdensome for a patient and enables stable blood access.

Abstract: A surgical drain system for use during and following surgery is provided. A collection reservoir is placed in fluid communication with the body of a user through a collection port. A pump creates a vacuum pressure to urge fluid into the collection reservoir. Fluid exits the collection reservoir through a drain port. A drain mechanism allows air to come into the collection reservoir through an air intake aperture and collected fluid to leave the reservoir simultaneously. The drain system can be worn beneath clothes.