Abstract: A wearable apparatus for the treatment or prevention of osteopenia or osteoporosis, stimulating bone growth, preserving or improving bone mineral density, and inhibiting adipogenesis is disclosed where the apparatus may generally comprise one or more vibrating elements configured for imparting repeated mechanical loads to the hip, femur, and/or spine of an individual at a frequency and acceleration sufficient for therapeutic effect. These vibrating elements may be secured to the upper body of an individual via one or more respective securing mechanisms, where the securing mechanisms are configured to position the one or more vibrating elements in a direction lateral to the individual, and the position, tension, and efficacy of these vibrating elements may be monitored and/or regulated by one or more accelerometers.

Abstract: The present disclosure provides an intragastric implant capable of inducing the feeling of satiety from inside the stomach, together with a delivery device for delivering said implant. The system and method provides greater access to minimally invasive weight loss procedures for patients who are only overweight or obese, reducing the risks associated with more invasive procedures.

Abstract: An intraoral device is disclosed. The device includes a curved portion configured to extend along a user's teeth, and first and second back portions connected to the curved portion. In addition, the device includes a first projection extending from a first back portion and the second projection extending from the second back portion. In some embodiments, the projections are positioned such that, when in the user's mouth, the projections are between upper and lower teeth of the user.

Abstract: A heating and cooling stimulation device includes a stimulation supply unit configured to supply hot stimulation and cold stimulation to a subject; an estimation unit configured to estimate a fatigue level of the subject; and a control unit configured to control an operation of the stimulation supply unit so as to supply the hot stimulation and the cold stimulation alternately to the subject in accordance with the fatigue level estimated by the estimation unit. The control unit controls the operation of the stimulation supply unit such that an amount of the cold stimulation received by the subject increases as the fatigue level estimated by the estimation unit becomes higher.

Abstract: A system for treating an eye includes a light source configured to provide photoactivating light that photoactivates a cross-linking agent applied to a cornea. The system includes one or more optical elements configured to receive the photoactivating light and produce a beam that defines a spot of the photoactivating light. The system includes a scanning system configured to receive the beam of the photoactivating light and to scan the spot of the photoactivating light along a first axis and a second axis to form a scan pattern on the cornea to generate cross-linking activity.

Abstract: An apparatus for mechanically coupling a motor to a rotor includes an outer ring including an inner surface shaped to define multiple recesses, an inner ring disposed within the outer ring and shaped to define multiple compartments having respective outer openings, which face the outer ring, and respective inner openings opposite the outer openings, and multiple gripping elements disposed within the compartments, respectively. The inner ring is configured to receive the rotor while the compartments are aligned with the of recesses, by virtue of the gripping elements sitting at least partially within the recesses. The outer ring is configured to couple with a shaft coupled with the motor such that rotation of the shaft by the motor causes the compartments to become misaligned with the recesses, thereby causing the outer ring to push the gripping elements, through the outer openings, against the rotor, through the inner openings.

Abstract: An ocular implant having an inlet portion and a Schlemm's canal portion distal to the inlet portion, the inlet portion being disposed at a proximal end of the implant and sized and configured to be placed within an anterior chamber of a human eye, the Schlemm's canal portion being arranged and configured to be disposed within Schlemm's canal of the eye when the inlet portion is disposed in the anterior chamber.

Abstract: In a laser cataract procedure that also corrects for astigmatism, an iris registration method compares an iris image of a patient's eye taken when the eye is not docked to a patient interface device with an iris image of the same eye that is docked to the patient interface, to calculate a rotation angle between the two images. The astigmatism axis of the eye is measured when the eye is not docked, and the measured axis is rotated by the calculated rotation angle to obtain a rotated astigmatism axis relative to the iris image of the docked eye. The laser cataract procedure is performed based on the rotated astigmatism axis. The rotation angle is calculated by optimizing a transformation that transforms the undocked iris image to match the docked iris image, where the transformation includes a dilation factor that accounts for different pupil dilation of the two iris images.

Abstract: The claimed embodiments relate to methods for characterizing a laser beam (24) of a laser processing system (30). The method includes a) providing an aperture arrangement (10) with a plurality of apertures (14) in a work plane (300) of the laser processing system (30) such that the apertures (14) extend within the work plane (300). The method also includes b) scanning the laser beam (24) along a scanning direction (200) parallel to the work plane (300) across the aperture arrangement (10) in such a way that the laser beam (24) at least partially sweeps over the apertures (14).

Abstract: Intraocular pressure in an eye is reduced by delivering each of a high resolution optical coherence tomography (OCT) beam and a high resolution laser beam through the cornea, and the anterior chamber into the irido-corneal angle along an angled beam path. The OCT beam provides OCT imaging for diagnostic purposes and surgery planning and monitoring, while the laser beam is configured to modify tissue. A volume of ocular tissue within an outflow pathway in the irido-corneal angle is modified to reduce a pathway resistance present in one or more of the trabecular meshwork, the Schlemm's canal, and the one or more collector channels by applying the laser beam to ocular tissue defining the volume to thereby cause photo-disruptive interaction with the ocular tissue to reduce the pathway resistance or create a new outflow pathway.

Abstract: An eye mask for sleeping has a headband and two eyecups. The headband comprises an inner surface and an outer surface. The two eyecups are configured to cover two eyes respectively. Each eyecup has an adhering surface, a contact surface, and multiple first passages. The adhering surface is securely mounted on the inner surface of the headband. The contact surface is configured to cover one of the eyes of the user. The first passages are formed through each eyecup and extend from the adhering surface to the contact surface. With the eyecups mounted on the headband and configured to cover the eyes of the user, because the first passages are formed through the eyecups, heat and moisture can be dissipated and drained via the first passages.

Abstract: An operating room air treatment system and method for handling airflow in zones in an operating room. The system provides a substantially vertical air flow zone that is located generally peripherally to the operating room table and a substantially central airflow zone that is located generally centrally in the operating room.

Abstract: A medical treatment apparatus includes a power and control (PAC) device. The PAC device provides electrical power through a cable to a laser handpiece assembly to electrically power a laser source within the handpiece assembly. The PAC device controls operation of the handpiece assembly and detects an identification of the handpiece assembly. The PAC device also monitors data relating to operation of the handpiece assembly. The PAC device uploads, through a communication network to a user assistance center remote from the PAC device, the handpiece assembly identification and the monitored data.

Abstract: Embodiments of the present disclosure provide a collapsible wheelchair, including: a movable chassis; a chair; a chair backrest; at least one first folding mechanism, installed between the movable chassis and the chair; and at least one second folding mechanism, connected between the chair and the chair backrest; where, the at least one first folding mechanism and the at least one second folding mechanism are connected in series and both have a four-rod linkage structure, and when the collapsible wheelchair is switched from a folded state to an open state or from the open state to the folded state, the at least one first folding mechanism and the at least one second folding mechanism are configured to move simultaneously. The collapsible wheelchair provided by the present disclosure is convenient in terms of the operation and easy to operate.

Abstract: A support device has a main support surface for a person's body, including an auxiliary device influencing the main support surface shape. The auxiliary device includes: a group of supports supporting the main support surface, positioned on the side of the main support surface facing away from the body-supporting side, the supports each including a sub-support surface; an adjuster for each sub-support surface influencing the height of each sub-support surface. The device also includes a monitor for each sub-support surface monitoring the height of the respective sub-support surface; and a programmable control unit controlling the adjuster. The supports include an elastically bendable plate connected to the adjuster. The bending plate is connected to the sub-support surface to influence its height depending on the extent of bending imposed by the adjuster. The adjuster includes an electromotor on the concave side of the bending plate.

Abstract: Provided is a wheel (6a) in which a disk (62) includes a ring-shaped rim (60) on which a tire (6b) is fitted, and a disk (62) having a flat circular shape and disposed on an inner circumference of the rim (60). The disk (62) includes a first rib (62a) and a second rib (62b) which extend in a radial direction of the disk (62). A width of each of the first rib (62a) and the second rib (62b) in a circumferential direction of the disk (62) increases toward an outer circumferential side of the disk (62).

Abstract: A reclining chair includes a frame and a back part with a back support slidably connected to a back frame hinged on a frame rotation point on the frame. A seat part, including a seat frame and a seat, is pivotably connected to the back frame at a chair joint. A reclining mechanism includes an arm pivot point fixed to the frame. A first arm extends from the arm pivot point to a second arm at an arm suspension point. The second arm is pivotably connected to the chair joint. When the back part reclines from an upright position, the back frame rotates, the first arm rotates, the chair joint moves towards the seat part, and a connecting arm extending from the back support and mechanically linked to the first arm and the second arm pulls the back support so the back support slides towards the seat part.

Abstract: A patient support apparatus includes a support frame and a patient support deck operatively attached to the support frame. The patient support deck includes an adjacent pair of deck sections with a first one of the deck sections moveable between an initial configuration and a raised configuration. A gap covering deck section is slidingly engaged to a top surface of the first or second one of the adjacent deck sections and is pivotably coupled to either the other one of the deck sections or to the support frame, with the gap covering deck section configured to slide along the top surface in response to the movement of the first one of the deck sections so as to be at least partially disposed over a gap between the adjacent deck sections when the first one of the deck sections is in the raised configuration.

Abstract: A patient support apparatus includes a base frame and an upper frame configured to support a mattress. The upper frame has a head portion including a recessed edge. Lift arms are coupled to the upper frame and configured to adjust a position of the upper frame. A first handle is coupled to the head portion on a first side of the recessed edge. A second handle is coupled to the head portion on a second side of the recessed edge. The first and second handles are configured to pivot inboard and toward one another to a lowered position extending over the upper frame adjacent to the recessed edge. An intravenous pole is pivotally coupled to the head portion and is adjustable between a deployed position and a stowed position. The intravenous pole extends along a rear wall of the recessed edge over the upper frame when in the stowed position.

Abstract: A patient support apparatus for transporting a patient over a floor surface is described herein. The patient support apparatus includes a drive system with a drive member, a user interface for receiving user commands from a user to operate the drive system, and a control system for operating the drive system. The control system includes a memory device configured to store a plurality of transition profiles and a controller configured to sense a plurality of positions of the drive member relative to the support structure, calculate a distance traveled by the patient support apparatus over the floor surface, compare the plurality of positions of the drive member and the distance traveled by the patient support apparatus with the transition profiles, and determine that the patient support apparatus is traveling on an inclined floor surface.

Abstract: A pressure sore prevention mattress is provided alternating pressure points on the body of an occupant that is easily transformable between two stable configurations. The four-layer mattress construction has a top foam pad, a webbing layer, a dynamic layer of deformable panels trapezoid-shaped four-bar mechanisms that deform to produce an undulating pattern of peaks, and a base. Panel geometry can determine peak height. The mattress has a spatially hollow geometry that allows natural air convection through the breathable top foam pad to enable drying of moisture as well as the use of forced air convective drying or cooling. The mattress can be transformed from one configuration to the other while the occupant is on the mattress.

Abstract: Introduced here are pressure-mitigation apparatuses able to mitigate the pressure applied to a human body by the surface of an object. A controller device can be fluidically coupled to a pressure-mitigation device that includes a series of selectively inflatable chambers. When a pressure-mitigation device is placed between a human body and a surface, the controller device can continuously, intelligently, and autonomously circulate air through the chambers of the pressure-mitigation device. As further discussed below, the controller device may cause the chambers to be selectively inflated, deflated, or any combination thereof. Such an approach is useful in a variety of contexts. For example, pressure-mitigation apparatuses may be used to improve treatment of patients suffering from respiratory illnesses and patients who are partially or completely immobilized for extended durations (e.g., as part of a medical procedure).

Abstract: A motorized rehabilitation device includes a mobile base bound by a lower surface and an upper surface. A first motorized wheel assembly is supported on the upper surface of the mobile base. The mobile base also includes a second motorized wheel assembly at least partially extending below the lower surface of the base. A dome is bound by an exterior convex surface and an interior concave surface. The dome is biased for friction contact of the interior concave surface with the first motorized wheel assembly. An end-effector is positioned above the exterior concave surface. The end-effector is configured to engage an animal body part.

Abstract: A complex rehabilitation technology system includes a frame and a complex rehabilitation technology device. This frame is movable between a collapsed carriable position and an expanded support position to facilitate portability or storage. The complex rehabilitation technology device is coupled to the frame. And, the complex rehabilitation technology device is configured to be operable when the frame is in the expanded support position. The complex rehabilitation system can be portable (e.g., configured for one-handed carrying).

Abstract: A product may include a mold assembly comprising a mold inner tube, a mold outer tube, a first end cap, and a second end cap, and an inner texture sleeve; a cured mold product comprising about 20 parts by weight of a dry powder and about 540 parts by weight of water; and at least one sleeve positioned circumferentially around the cured mold product being constructed and arranged to provide constrictive force on the cured mold product.

Abstract: A manual ear pump including one or more of a support element configured to releasably engage an external ear canal and having an interior chamber, a resilient element capable of being resiliently deformed coupled to a support element, and an aperture disposed on a support element bottom surface communicating with the external ear canal and interior chamber.

Abstract: An apparatus for generating an acoustic energy pulse and delivering it into a body is described. The apparatus includes a generator for creating an acoustic energy pulse having an energy density field that can be measured at all points within a space in the shape of an imaginary cylinder having a length greater than or equal to 2 cm and a diameter. The cylindrically shaped space has a cylinder longitudinal axis oriented relative to a longitudinal axis of the energy pulse at an angle in the range from zero to twenty degrees. A minimum energy density for the pulse at all locations within the cylindrically shaped space is at least 50% of a maximum energy density for the pulse within the space.

Abstract: A vibration therapy device that includes a housing that includes a handle portion, a head portion and a module seat defined on the head portion, an electrical source, a motor positioned in the housing, a switch for activating the motor, a push rod assembly operatively connected to the motor and configured to reciprocate in response to activation of the motor, and a therapy module removably secured to the module seat. The distal end of the push rod assembly is configured to removably receive a reciprocating attachment thereon. The therapy module at least partially surrounds the distal end of the push rod assembly.

Abstract: A method to treat a dry eye condition of an individual, includes: receiving a switch signal generated based on a manipulation of a control switch at a handheld device; and activating a motor in response to the switch signal to oscillate a member at an oscillation frequency, the member having an elongated configuration, and having a portion for placement outside the individual; wherein the oscillation frequency is sufficient to induce tear production when the portion of the member is applied towards a surface of a body portion of the individual.

Abstract: Systems and methods for applying enhanced guided active compression decompression cardiopulmonary resuscitation are provided. Exemplary systems include a load cell, a handle, an adhesive pad. The handle and the adhesive pad are configured for magnetic coupling.

Abstract: Acupuncture needles may be used for piercing tissue with less trauma than may occur when employing larger gauge needles. However, because acupuncture needles are fabricated and packaged differently than are larger gauge needles, acupuncture needles may be less compatible with certain manufacturing processes. Needle assemblies compatible with manufacturing processes may comprise a continuous support material having a plurality of apertures defined therein, and a first injection molded coupler that surrounds a proximal portion of an acupuncture needle and connects the acupuncture needle to a first location upon the continuous support material, such that the acupuncture needle is held in a pre-determined orientation with respect to a longitudinal axis of the first injection molded coupler. The acupuncture needles in adjacent apertures may also be spaced apart substantially uniformly.

Abstract: A system of placeable and removable pressure nodules is provided having different types of size and configuration and having a density semi-soft, to rigid. The nodules are removably attachable and affixable into a back brace modified and adapted to implement SMRT. Precise, specialized, and individualized pressure is provided to the muscles, tendons, and connective tissues through the nodules in order to alleviate any need for manual massage. The user's own active motions (bending, twisting, walking) engages the muscles and massage the muscles with the pressure nodules.

Abstract: A pharmaceutical management system includes: an IC tag attached to a pharmaceutical; a pharmaceutical storage box to store the pharmaceutical and read information of the IC tag; a controller to acquire the information of the IC tag from the pharmaceutical storage box and manage the pharmaceutical; and a pharmaceutical refrigerator to store the pharmaceutical storage box to refrigerate the pharmaceutical.

Abstract: A long, thin, flexible medical apparatus, a kit, and a method placing, confirming, and visualizing placement of a gastric tube. The apparatus comprises an elongate body portion, a handle, and a distal tip portion. An ability to insert and remove the body and distal tip portions in relation to the gastric tube over the length of the long, thin, flexible structure provides a positive indication that the lumen is not blocked, obstructed, or otherwise compromised over that length. pH indicator sensors and, additionally or alternatively, radiopaque markers may be retained by the distal tip portion. The pH sensors exhibit a verifiable color change in response to contact with a predetermined subject fluid. The radiopaque markers enable a determination with certainty of the location and orientation of the distal tip portion of the apparatus and of the distal portion of a gastric tube in which the apparatus is disposed.

Abstract: A non-electrically driven enteral feeding pump including an expandable elastomeric bladder is provided. The enteral feeding pump includes a fluid delivery tube. The fluid delivery tube controls flow rate of fluid from the pump. The present invention further describes an enteral feeding pump assembly including the portable enteral feeding pump and a peristaltic pump. The peristaltic pump can be configured to be operatively coupled to the elastomeric bladder of the enteral feeding pump for transferring fluid from a reservoir external to the elastomeric bladder into a chamber of the elastomeric bladder.

Abstract: There is provided a system for monitoring a heart of a subject and monitoring impedance-related parameters, comprising: a feeding tube, an electrode disposed(s) on a distal end of the feeding tube, a controller that performs, while the feeding tube is in located in an esophagus and feeding is delivered to a subject via the feeding tube, in a plurality of iterations: continuously measuring voltage at the electrode(s) of the feeding tube, applying alternating current(s) between the electrode(s) of the feeding tube and at least one other electrode, computing impedance measurement(s) from the electrode(s) of the feeding tube according to the applied alternating current(s) and the measured voltage, computing impedance-related parameter(s) based on the impedance measurement(s), terminating the application of the alternating current(s), obtaining an electrocardiogram (ECG) measurement based on the voltage measured at the electrode(s) of the feeding tube, and providing the impedance-related parameter(s) and the ECG m

Abstract: The present invention relates to a process for the preparation of a solid pharmaceutical administration form using a 3D printing process as well. The process is a printing process that allows the production of solid pharmaceutical administration forms in a flexible manner and in conformity with the high quality standards required for the production of pharmaceuticals.

Abstract: A medication dispensing system is provided with several cooperating components which help to accommodate the responsible handling of medications. These systems include a user interface to receive input from the user and to present appropriate information/notices/alarms. Further, physical controls and multiple sensors are provided to detect tampering, misuse, and attempts to inappropriately access medications contained within the dispensing system. This misuse can thus be detected, and appropriate notifications can be provided, where appropriate. Further, by adding network communications capabilities, notices can be widely communicated to others, and operation of the medication dispensing system can be controlled and/or monitored remotely.

Abstract: The present disclosure relates to the transdermal administration of cannabidiol (CBD) for the reduction of seizure frequency in the treatment of “treatment-resistant epilepsy” (TRE).

Abstract: The present invention provides a high-dose oral pharmaceutical composition and high drug loading of isotretinoin with low fill-weight, and smaller size capsules, and methods of preparation and use thereof.

Abstract: The present invention relates to the use of diluted, thus non-sclerosing, polidocanol solutions as immunomodulating and anti-inflammatory agents. The inventions further relates to non-sclerosing compositions 5 comprising polidocanol in concentration of from 0.03 to 0.10% w/V for the treatment of psoriatic skin rashes, for cosmetic use and for the reduction of peripheral venous stasis.

Abstract: The present invention provides a method for safe and efficacious administration of esketamine.

Abstract: Exemplary embodiments of the present invention relate to a combination formulation for treatment or enhancing the therapy of liver disease, and more particularly, to a combination formulation prepared by containing colchicine and metformin as main active ingredients. The composition according to exemplary embodiments of the present invention may be used as an effective therapeutic agent for liver disease capable of treating and preventing liver fibrosis, liver cirrhosis, liver cancer, or hepatitis by reducing the amount of fat accumulated in the liver tissues by a synergistic effect of colchicine and metformin and lowering glucose tolerance and insulin tolerance and further, may be used as an excellent drug capable of replacing ursodeoxycholic acid.

Abstract: Methods of treating or preventing cancer, diabetes, and/or obesity in a subject are provided. The methods comprise administering to a subject a therapeutically effective amount of an SLC25A1 inhibitor as described herein. Also provided herein are pharmaceutical compositions comprising an SLC25A1 inhibitor and a chemotherapeutic agent. Further provided herein are methods of inhibiting SLC25A1 in a cell.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

Abstract: Provided herein are compounds and their pharmaceutically acceptable salts, lipid particles comprising such compounds or pharmaceutically acceptable salts thereof and compositions of the foregoing that can be used to reduce immune intolerance in a subject, for example, to treat autoimmune disorders, or in combination with an antigenic therapy, such as a protein or gene therapy, to improve the efficacy of the antigenic therapy. The compounds have the following structural formula: wherein values for the variables (e.g., Ring A, L, R1, R2, R3, m) are as described herein.

Abstract: The present disclosure describes novel PKC-? activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monounsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.

Abstract: A method for producing a fatty acid-cannabinoid-plasma protein (FCP) composition, the method comprising: contacting a plasma protein or a peptide portion thereof with a supplemental fatty acid composition comprising at least one fatty acid; and contacting the plasma protein or portion thereof with a cannabinoid composition comprising at least one cannabinoid, such that a combined composition is prepared, which comprises a FCP complex in which the at least one fatty acid and the at least one cannabinoid is bound to the plasma protein or portion thereof.

Abstract: A process for producing a vegan cannabinoid chewy wherein the process entails mixing a cannabinoid compound with a sugar solution, pectin mixture, and agar mixture.

Abstract: The present invention relates to a controlled release formulation comprising the active compounds tesofensine and a beta blocker, such as metoprolol or carvedilol, or a pharmaceutically acceptable salt thereof. The invention further relates to use of the controlled release formulation in a method of treatment of diabetes, obesity, or an obesity associated disorder.