Patents Issued in July 25, 2024
  • Publication number: 20240247286
    Abstract: The present disclosure relates to methods, kits, and compositions for improving the efficiency of homologous recombination. In particular, the disclosure relates to methods for cloning DNA molecules directly into a genome with the combined use of promoter trapping and short homology arms, nuclear localization signal, and/or binding one or more DNA binding agents (TAL effector domain or truncated guide RNA bound by Cas9) to specific sites thereby displacing or restructuring chromatin at the target locus, and/or it increasing the accessibility of the target locus to further enzymatic modifications. The methods and compositions provided herein are, inter alia, useful for genome editing and enhancing enzymatic processes involved therein.
    Type: Application
    Filed: September 29, 2023
    Publication date: July 25, 2024
    Inventors: Xiquan LIANG, Robert Jason POTTER, Lansha PENG
  • Publication number: 20240247287
    Abstract: The present invention provides: a single-strand form polynucleotide for promoting editing and to be combined with a single-strand form polynucleotide for editing and capable of modifying a target site in double-strand genomic DNA; a genome editing kit that includes said polynucleotide for editing or an expression vector therefor, and said polynucleotide for promoting editing or an expression vector therefor; a method for modifying a target site in double-strand genomic DNA of a cell or a non-human organism, the method comprising a step for treating the cell or the organism using the genome editing kit; and a method for producing a cell or an organism in which a target site in double-strand genomic DNA is modified, the method comprising said step.
    Type: Application
    Filed: April 8, 2022
    Publication date: July 25, 2024
    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventor: Hideaki MASEDA
  • Publication number: 20240247288
    Abstract: A method for cyclic biochemical conversion of carbon dioxide and hot gas cogeneration in depleted oil and gas reservoirs includes: S1: selecting a target depleted oil and gas reservoir; S2: adjusting a temperature of the target depleted oil and gas reservoir to 30° C. to 70° C. and detecting whether formation water of the target depleted oil and gas reservoir contains methanogenic archaea, in which if no methanogenic archaeon is contained, then methanogenic archaea is injected and step S3 is proceeded, and if methanogenic archaea are contained, then step S3 is proceeded directly; S3: injecting a mixture of carbon dioxide and hydrogen into the target depleted oil and gas reservoir through a gas injection well; and S4: shutting down the gas injection well to wait for the methanogenic archaea to convert carbon dioxide and hydrogen into methane and exploiting the methane and heat energy in the target depleted oil and gas reservoir.
    Type: Application
    Filed: February 6, 2024
    Publication date: July 25, 2024
    Applicants: Southwest petroleum university, Zhengzhou University
    Inventors: Zhengmeng Hou, Lin Wu, Liangchao Huang, Zhifeng Luo, Jianhua Liu, Ming Dou, Xuning Wu, Qianjun Chen, Cong Lu
  • Publication number: 20240247289
    Abstract: Methods, compositions, and systems for antibiotic-free propagation and fermentation using hops and formic acid, particularly large-scale operations for production of a bioproduct are provided. Hops and formic acid are combined in amounts sufficient to minimize growth of contaminating bacteria.
    Type: Application
    Filed: January 12, 2024
    Publication date: July 25, 2024
    Inventors: Benjamin Gacke, Stephen M. Lewis
  • Publication number: 20240247290
    Abstract: The invention provides recombinant algal mutants that have a genetic modification to a gene or nucleic acid sequence encoding a WD40 repeat containing protein or domain. The genetic modification of one or more nucleic acid sequences encoding a WD40 repeat containing protein or domain results in a mutant organism with increased lipid productivity and/or higher biomass productivity (as measured by total organic carbon). The genetic modification can be a gene attenuation or functional deletion. The lipid products of these mutants can be utilized as biofuels or for other specialty chemical products. Methods of making and using the recombinant algal mutants and methods of producing lipids are also disclosed.
    Type: Application
    Filed: April 10, 2024
    Publication date: July 25, 2024
    Inventors: Saheed Imam, Eric R. Moellering, Luke Peach, Wiilliam F. Lambert, Kathleen Kwok
  • Publication number: 20240247291
    Abstract: The invention described herein provides methods and materials that can impart long-term stability to polyelectrolyte complex coacervate droplets and create complex coacervate emulsions. The methodology described herein is designed to use one or more of a wide variety of comb polyelectrolytes in order to produce stable water-in-water emulsions with precisely controlled droplet size and enhanced stability profiles. The stabilized water-in-water emulsions microdroplets of the invention can further encapsulate active agents such as proteins and the like in a manner that protects them from the surrounding environment, thus allowing the compositions to serve as bio-microreactors and the like.
    Type: Application
    Filed: May 11, 2022
    Publication date: July 25, 2024
    Applicant: The Regents of the University of California
    Inventors: Samanvaya Srivastava, Shang Gao, Advait Suhas Holkar
  • Publication number: 20240247292
    Abstract: Culturing S. glucoliberatum PABB004 under conditions effective for the S. glucoliberatum PABB004 to secrete simple sugars into culture medium. In one or more embodiments, the conditions include a pH of 6.0 to 8.5. In some cases, the culture can include a second organism. A co-culture includes S. glucoliberatum PABB004 and a second organism, wherein the co-culture has a pH of 6.0 or greater. In one or more embodiments, the second organism is selected to produce a product of interest such as, for example, ethanol.
    Type: Application
    Filed: February 12, 2024
    Publication date: July 25, 2024
    Inventors: Brett M. Barney, Evelyn Vogel, Natalia Calixto Mancipe
  • Publication number: 20240247293
    Abstract: This present disclosure provides a method for preparing chondroitin sulfate from tilapia skull, including enzymatic hydrolyzing tilapia skull powder by Savinase 16L to obtain Savinase 16L enzymatic hydrolysate, re-enzymatic hydrolyzing the Savinase 16L enzymatic hydrolysate by 2709 alkaline protease, then separating and purificating the solution by ethanol and cetylpyridine chloride to obtain the chondroitin sulfate. The present disclosure adopts a compound enzymatic hydrolyzing method by Savinase 16L and 2709 alkaline protease to effectively achieve the efficient extraction of chondroitin sulfate of tilapia skull powder, and further achieve the purification of chondroitin sulfate by ethanol and cetylpyridine chloride, so that tilapia by-products can be utilized with high value.
    Type: Application
    Filed: March 24, 2022
    Publication date: July 25, 2024
    Inventors: Saiyi ZHONG, Gege ZUO, Jing CHEN, Jianping CHEN, Rui LI, Bingbing SONG, Kangjian CHEN, Xiaofei LIU, Xuejing JIA
  • Publication number: 20240247294
    Abstract: The present invention includes novel systems, methods, and compositions for the enzymatic/chemical production of pseudouridine (?) and its variants, such as N1-methyl-pseudouridine-5?-triphosphate (m1?TP).
    Type: Application
    Filed: March 21, 2024
    Publication date: July 25, 2024
    Inventors: Alexander Koglin, Michael Humbert, Matthias Strieker, Grant Eliason
  • Publication number: 20240247295
    Abstract: The present invention relates to the technical field of nucleic acids, and in particular, to a method for precisely preparing a circular RNA with an Anabaena intron self-cleaving ribozyme. By redesigning a target nucleic acid sequence of a linear RNA, selecting a site suitable for precise cleavage by the intron self-cleaving ribozyme, and removing exon sequences from the Anabaena intron self-cleaving ribozyme, precise cyclization of RNAs after in vitro transcription is achieved. The method provided by the present invention solves the problem in the prior art that linear RNAs cannot be precisely cyclized during the process of generating circular RNAs in vitro, and provides an ideal in vitro preparation method for circular RNA applications.
    Type: Application
    Filed: February 1, 2024
    Publication date: July 25, 2024
    Applicant: Guangzhou Geneseed Biotech Co.,Ltd.
    Inventors: Ming LIU, Maolei ZHANG, Yesheng WANG, Qiujie CAI, Wanjun ZHANG, Xiaodan MA
  • Publication number: 20240247296
    Abstract: A multijunction solar cell including an upper first solar subcell having a first band gap and positioned for receiving an incoming light beam; and a second solar subcell disposed below and adjacent to and lattice matched with said upper first solar subcell, and having a second band gap smaller than said first band gap; wherein at least one of the solar subcells has a graded band gap throughout the thickness of at least a portion of its emitter layer and base layer.
    Type: Application
    Filed: October 9, 2023
    Publication date: July 25, 2024
    Applicant: SolAero Technologies Corp.
    Inventors: John Hart, Daniel Derkacs, Zachary Bittner, Andrew Espenlaub
  • Publication number: 20240247297
    Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.
    Type: Application
    Filed: March 6, 2024
    Publication date: July 25, 2024
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Tianmei OUYANG, Benjamin J. FELDMAN
  • Publication number: 20240247298
    Abstract: A method for detecting live lactic acid bacteria with carbohydrate metabolism activity contained in a lactic acid bacteria-containing beverage or food includes adding a reagent that exhibits fluorescence when degraded by an esterase and a reagent for determining cell membrane damage to a lactic acid bacteria-containing beverage or food; adjusting a hexose having an aldehyde group contained in the lactic acid bacteria-containing beverage or food to 0.01 mM or more; and detecting lactic acid bacteria that excrete a fluorescent substance and have no cell membrane damage from the lactic acid bacteria-containing beverage or food.
    Type: Application
    Filed: May 16, 2022
    Publication date: July 25, 2024
    Applicant: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hiroyuki KUBOTA, Masaki SERATA, Takekazu OKUMURA
  • Publication number: 20240247299
    Abstract: A method of testing compounds for activity to inhibit germination of spores.
    Type: Application
    Filed: April 10, 2024
    Publication date: July 25, 2024
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Christina Marie HULL, Mingwei HUANG, Sebastien Claude Ortiz
  • Publication number: 20240247300
    Abstract: In an embodiment, the present disclosure pertains to a method for evaluation of sterility in a solution using impedance sensing. In another embodiment, the present disclosure pertains to a method for evaluation of bioburden in a solution. In a further embodiment, the present disclosure pertains to various devices for evaluation of sterility or bioburden.
    Type: Application
    Filed: May 13, 2022
    Publication date: July 25, 2024
    Applicant: The Texas A&M University System
    Inventors: Arum Han, Paul J. de Figueiredo
  • Publication number: 20240247301
    Abstract: The present disclosure relates to a diagnostic assay to detect classic inborn galactosemia. The assay comprises detecting defective galactose metabolism using a substrate-specific recombinant phosphatase derived from Salmonella.
    Type: Application
    Filed: December 6, 2023
    Publication date: July 25, 2024
    Inventors: Venkat Gopalan, Eleanor Bashian, Pankajavalli Thirugnanasambantham
  • Publication number: 20240247302
    Abstract: Disclosed herein are methods for generating a massive number of chemically ligateable probes for multiplexed Fluorescence In Situ Hybridization (FISH) using a hybrid-primer. Also, the disclosure sets forth methods, in addition to using the same, and other solutions to problems in the relevant field.
    Type: Application
    Filed: May 27, 2022
    Publication date: July 25, 2024
    Inventors: Long CAI, Chee Huat (Linus) ENG
  • Publication number: 20240247303
    Abstract: Provided herein are systems and methods for processing biomolecules (e.g., nucleic acid molecules, proteins) from a sample. A method for processing biomolecules may comprise barcoding the probe-nucleic acid molecule complex or derivatives thereof. Such a method can comprise performing a nucleic acid reaction, e.g., extension, denaturation, and amplification. The methods described herein may be performed within a partition, such as a droplet or well.
    Type: Application
    Filed: December 21, 2023
    Publication date: July 25, 2024
    Inventors: Katherine PFEIFFER, Zahra Kamila BELHOCINE
  • Publication number: 20240247304
    Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more non-nucleic acid targets of interest in a sample. The compositions and methods provide signal boost upon detection of non-nucleic acid targets of interest in less than one minute and in some instances instantaneously at ambient temperatures down to 25° C. or less, allow for massive multiplexing, high accuracy, minimal non-specific signal generation, and are easily reprogrammable.
    Type: Application
    Filed: March 21, 2024
    Publication date: July 25, 2024
    Inventors: Swetha Murali, Andrew Garst, Anurup Ganguli, Ketki Sawant, Ravi Vijayendran
  • Publication number: 20240247305
    Abstract: Provided are methods and systems for detecting formation of nucleotide-specific ternary complexes comprising a DNA polymerase, a nucleic acid, and a nucleotide complementary to the templated base of the primed template nucleic acid. The methods and systems facilitate determination of the next correct nucleotide without requiring chemical incorporation of the nucleotide into the primer. This advantageously improves signal-to-noise ratios and increases the quality of results obtainable in a sequencing-by-binding protocol, and enables extended read lengths. These results can even be achieved in procedures employing unlabeled, native nucleotides.
    Type: Application
    Filed: July 28, 2023
    Publication date: July 25, 2024
    Applicant: Pacific Biosciences of California, Inc.
    Inventor: Corey M. DAMBACHER
  • Publication number: 20240247306
    Abstract: Cross-contamination of a test sample used to determine cancer is identified using gene sequencing data. Each test sample includes a number of test sequences that may include a single nucleotide polymorphism (SNP) that can be indicative of cancer. The test sequences are be filtered to remove or negate at least some of the SNPs from the test sequences. Negating the test sequences allows more test sequences to be simultaneously analyzed to determine cross-contamination. Cross-contamination is determined by modeling the variant allele frequency for the test sequences as a function of minor allele frequency, contamination level, and background noise. In some cases, the variant allele frequency is based on a probability function including the minor allele frequency. Cross-contamination of the test sample is determined if the determined contamination level is above a threshold and statistically significant.
    Type: Application
    Filed: April 4, 2024
    Publication date: July 25, 2024
    Inventors: Onur Sakarya, Catalin Barbacioru
  • Publication number: 20240247307
    Abstract: The present invention provides a fluorescence detection chip, a fluorescence detection system, a fluorescence detection method and an application thereof. The fluorescence detection chip comprises an upper casing and a lower casing, and further comprises a sample cell, a mixed liquid cell, a waste liquid cell and a number of independent reaction detection cells, wherein the reaction detection polls have cell walls made of a superconducting thermal material; wherein the sample cell, the mixed liquid cell, the waste liquid cell and the reaction detection cells are all arranged in the lower casing, and in the upper casing a number of feeding ports are provided, which correspond to the sample cell, the mixed liquid cell and the reaction detection cells, respectively. By means of a micro-channel design, a reaction liquid is fully mixed during the flow process, and is evenly distributed to the respective reaction detection cells.
    Type: Application
    Filed: June 15, 2022
    Publication date: July 25, 2024
    Applicant: HEFEI NUOMAIJI BIOTECH CO., LTD
    Inventor: Yuchao LIU
  • Publication number: 20240247308
    Abstract: A method of conducting an assay for a set of targets, comprising: subjecting each target of a set of targets to a recognition event, in which each target is uniquely recognized by and bound to a recognition element associated with a code from a set of codes, thereby yielding a set of coded targets comprising the target and the recognition element; subjecting each recognition element of the set of coded targets to a transformation event, in which a molecular transformation of each recognition element produces a modified recognition element, thereby yielding a set of modified recognition elements comprising the code; subjecting each code of the set of modified recognition elements to an amplifying event, in which each code is amplified, thereby yielding a set of amplified codes; subjecting each amplified code of the set of amplified codes to a detection event, thereby decoding the code.
    Type: Application
    Filed: December 20, 2023
    Publication date: July 25, 2024
    Inventors: Lorenzo BERTI, Jeffrey BRODIN, Donald Brian EIDSON, Christian SCHLEGEL, Angela BLUM, Rachel SCHOWALTER, Ludovic VINCENT, Pieter VAN ROOYEN, Gavin STONE
  • Publication number: 20240247309
    Abstract: The invention generally relates to sequencing library preparation methods. In certain embodiments, two or more template nucleic acids are joined together by a linking molecule, such as a PEG derivative. Identical copies of a nucleic acid fragment or both strands of a duplex fragment may be linked together. The linked nucleic acids are amplified, creating linked amplicons. Emulsion PCR with linked primers creates linked template nucleic acids for seeding sequencing clusters and errors can be readily identified by their presence on only one of the linked fragments.
    Type: Application
    Filed: February 16, 2024
    Publication date: July 25, 2024
    Inventors: Joel Pel, Andrea Marziali
  • Publication number: 20240247310
    Abstract: This document provides methods and materials for using low coverage whole genome sequencing techniques to assess genomes. For example, methods and materials for using targeted nucleic acid amplification and/or capture techniques in combination with low coverage whole genome sequencing techniques to obtain high coverage sequencing data for one or more pre-selected regions of a genome are provided.
    Type: Application
    Filed: April 11, 2024
    Publication date: July 25, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Jean-Pierre A. Kocher, Chen Wang
  • Publication number: 20240247311
    Abstract: The present application relates to palladium catalyst composition and uses in sequencing by synthesis. In particular, the Pd catalyst composition comprises one or more macrocycles (e.g., cyclodextrin or analogs thereof) as additives for improving thermal or oxidative stability of the active Pd(0) species.
    Type: Application
    Filed: December 20, 2023
    Publication date: July 25, 2024
    Inventors: Cassio Pedroso, Adyasha Panigrahi, Angelica Mariani, Adam Carver, Raphaëlle Hours, Preeti Chandrachud, Antoine Francais, Tushar Apsunde, Kathryn Hattingh, Timothy Beech, Daniel Solis, Elliot J. Lawrence
  • Publication number: 20240247312
    Abstract: An in vitro or ex vivo method for determining the risk of incidence of a healthcare-associated infection in a patient, including a step of measuring the expression of at least one gene encoding a pro-inflammatory cytokine receptor located on chromosome 2 in the region 2q11-2q12, in a biological sample from the patient.
    Type: Application
    Filed: July 5, 2021
    Publication date: July 25, 2024
    Applicants: BIOMÉRIEUX, BIOASTER
    Inventors: Laurence VACHOT, François MALLET, Guillaume MONNERET, Virginie MOUCADEL, Alexandre PACHOT, Estelle PERONNET, Thomas RIMMELÉ, Julien TEXTORIS, Fabienne VENET
  • Publication number: 20240247313
    Abstract: The gene responsible for encoding SERT has a functional polymorphism at the 5?-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3? UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.
    Type: Application
    Filed: December 22, 2023
    Publication date: July 25, 2024
    Inventor: Bankole A. Johnson
  • Publication number: 20240247314
    Abstract: A method for diagnosing or assisting diagnosing or screening or assisting screening of whether a subject to be tested suffers from Parkinson's syndrome includes use of a substance for measuring the content of synaptotagmin-11, or use of synaptotagmin-11 as a marker of Parkinson's syndrome.
    Type: Application
    Filed: May 30, 2022
    Publication date: July 25, 2024
    Inventors: Changhe Wang, Xinjiang Kang, Yuhao Gu, Zhenli Xie
  • Publication number: 20240247315
    Abstract: A method of diagnosing an inflammatory bowel disease (IBD) of a subject is disclosed. The method comprises analyzing the RNA expression level of particular human gene in a fecal RNA sample of the subject, wherein when the expression level is above a predetermined amount it is indicative of the inflammatory bowel disease.
    Type: Application
    Filed: July 21, 2022
    Publication date: July 25, 2024
    Inventors: Shaul Shalev Itzkovitz, Keren Bahar Halpern, Adi Egozi, Shomron Silan Ben-Horin, Bella Ungar, Shani Ben-Moshe
  • Publication number: 20240247316
    Abstract: The present disclosure discloses a set of novel epigenetic biomarkers for early detection, prediction of treatment response and prognosis of colorectal cancer. Aberrant methylation of the epigenetic biomarkers can be detected in tumor tissues and plasma samples from colorectal cancer patients but not in normal individuals. The present disclosure also discloses primers and probes used herein.
    Type: Application
    Filed: April 29, 2021
    Publication date: July 25, 2024
    Inventors: Ruo-Kai LIN, Chin-Sheng HUNG, Sheng-Chao WANG, Shih-Yun LIN
  • Publication number: 20240247317
    Abstract: There is provided a method of characterising a macrophage in a tissue of a subject, wherein the method comprises determining an expression of one or more biomarkers in the macrophage, wherein the one or more biomarkers is selected from the group consisting of Folr2, SerpinaSi, Nid2, Slc27a6, SemaSa, Cdh13, Bcl6b, C6, Klf15, Marco, Cd209d, Tshz3, Bmpr1a, Tln2, Coro2b, Ackr2, 1110046J04Rik, Pcdhac2, Gm2253, Vsig4, Phactrt, NpM, CpneS, Angptl7, Gm26714, Auts2, Cxcl13, Sgce, 2900052N01 Rik, Cd209b, Timd4, Cd209g, Mrd (CD206), Spp1, Il22ra2, Gm24112, Gm23010, Ighv7-1, Gm23628, Gm24620, Gm23058, Arhgef37, Gad1-ps, Gm26397, Ighv2-5, Chil3, Mir1934, 1810012K08Rik, Ighv1-59, Gm14119, Gm19620 and Snord71. In one embodiment, the macrophage can be an embryo-derived macrophage and/or a long-lived tissue resident macrophage. In another embodiment, the macrophage can be a monocyte-derived macrophage.
    Type: Application
    Filed: August 4, 2021
    Publication date: July 25, 2024
    Inventors: Camille Bleriot, Florent Ginhoux, Ankur Sharma
  • Publication number: 20240247318
    Abstract: The invention relates to methods for detecting inactivation of the DNA Homologous Recombination pathway in a patient, and in particular for detecting BRCA1 inactivation.
    Type: Application
    Filed: February 14, 2024
    Publication date: July 25, 2024
    Applicants: Institute Curie, INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Marc-Henri Stern, Elodie Manie, Tatiana Popova
  • Publication number: 20240247319
    Abstract: Provided herein are methods for determining the microsatellite instability status of samples. In one aspect, the methods include quantifying a number of different repeat lengths present at each of a plurality of microsatellite loci from sequence information to generate a site score for each of the plurality of the microsatellite loci. The methods also include comparing the site score of a given microsatellite locus to a site specific trained threshold for the given microsatellite locus for each of the plurality of the microsatellite loci and calling the given microsatellite locus as being unstable when the site score of the given microsatellite locus exceeds the site specific trained threshold for the given microsatellite locus to generate a microsatellite instability score, which includes a number of unstable microsatellite loci from the plurality of the microsatellite loci.
    Type: Application
    Filed: November 2, 2023
    Publication date: July 25, 2024
    Inventors: Aliaksandr ARTSIOMENKA, Marcin Pawel SIKORA, Catalin BARBACIORU, Darya CHUDOVA, Martina I. LEFTEROVA
  • Publication number: 20240247320
    Abstract: Described herein are high throughput-adaptable methods of detecting and quantifying telomere sequences, and particularly telomere sequences of shorter than average length, starting from extracted genomic DNA. Applications of the noted methods, such as to characterize age and health of a subject, for screening active agents to increase cellular longevity, and assessing the efficacy of treatments for diseases associated with shorter than average telomeres are also described.
    Type: Application
    Filed: May 26, 2022
    Publication date: July 25, 2024
    Applicant: Centarix Biotech Ltd
    Inventors: Noam Maoz, Yitzchak Dershowitz, Shimon Meshi, Hodaya LAUFER
  • Publication number: 20240247321
    Abstract: The present invention relates to a method for detecting Cystoisospora suis in a sample. The invention also relates to kits and materials, such as primers or probes, which can be used for such detection. The invention may be used in any sample, such as a biological sample, and allows specific detection of Cystoisospora suis.
    Type: Application
    Filed: October 6, 2021
    Publication date: July 25, 2024
    Inventors: Zalan Hommonnay, Itsvan Kiss
  • Publication number: 20240247322
    Abstract: The present invention concerns methods for detecting SARS-CoV 2 virus omicron, alpha, beta, delta and/or gamma as well as kits for performing such methods.
    Type: Application
    Filed: January 20, 2023
    Publication date: July 25, 2024
    Inventors: Doris Esther Gómez-Camargo, Steev Orlando Loyola Sosa
  • Publication number: 20240247323
    Abstract: Methods, systems, compositions and kits for using a multiplexed assay on a sample that is obtained from a subject are disclosed. The methods, systems, compositions and kits may comprise obtaining a sample from a subject that is in a location distal from where the assay is performed. The subject may obtain the sample without the presence of another individual. The methods, systems, compositions and kits may allow an assay to be run without addition of a reagent after the sample is received from the subject and prior to running an assay.
    Type: Application
    Filed: April 13, 2021
    Publication date: July 25, 2024
    Inventors: Aditya RAJAGOPAL, Alex DICKINSON, Vernon NORVIEL, Lucien JACKY, John ANNALORO, John ALVARADO
  • Publication number: 20240247324
    Abstract: This disclosure concerns amplification primers, hybridization assay probes, compositions containing such primers and probes, and associated reagents, kits, and methods, that can be used to analyze samples for the presence of Influenza A virus, Influenza B virus, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B target nucleic acids.
    Type: Application
    Filed: April 3, 2024
    Publication date: July 25, 2024
    Inventors: Matthias Jost, Pamela Douglass, Daniel P. Kolk, Mehrdad R. Majlessi
  • Publication number: 20240247325
    Abstract: This disclosure concerns amplification primers, hybridization assay probes, compositions containing such primers and probes, and associated reagents, kits, and methods, that can be used to analyze samples for the presence of Influenza A virus, Influenza B virus, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B target nucleic acids.
    Type: Application
    Filed: April 3, 2024
    Publication date: July 25, 2024
    Inventors: Matthias Jost, Pamela Douglass, Daniel P. Kolk, Mehrdad R. Majlessi
  • Publication number: 20240247326
    Abstract: Disclosed is a preparation method of a plant biomass-based active tanning agent. Under a low-temperature reaction condition, cyanuric chloride and a plant biomass compound are used to synthesize an environment-friendly plant biomass-based active tanning agent through a nucleophilic substitution reaction. The active tanning agent obtained in the present disclosure appears as a white or light brown emulsion at room temperature, and has substantial active groups such as hydroxyl groups, carboxyl groups and ester groups introduced into its structure, thus endowing leathers with desirable hydrothermal stability and physical properties and having a desirable synergistic effect with metal tanning agents. Meanwhile, health and environment risks caused by hexavalent chromium and free formaldehyde in leathers are avoided.
    Type: Application
    Filed: June 1, 2022
    Publication date: July 25, 2024
    Applicant: SICHUAN UNIVERSITY
    Inventors: Wei Lin, Yuanhang Xiao, Chunhua Wang, Min Jiang
  • Publication number: 20240247327
    Abstract: The present disclosure relates to systems and methods for the production of molten metals direct oxidative combustion of one or more solid fuels. The systems and methods may be combined with coal gasifiers and related components for reducing overall energy requirements as well as external fuel sources, e.g., through the use of endogenously-generated hydrogen. In beneficial aspects, components of the carbonaceous exhaust produced in accordance with the disclosed systems and methods, such as carbon dioxide (CO2), may be isolated using carbon capture and sequestration (CCS) for reducing associated greenhouse gas emissions.
    Type: Application
    Filed: January 24, 2024
    Publication date: July 25, 2024
    Inventor: Rodney John Allam
  • Publication number: 20240247328
    Abstract: A converter bottom blowing system comprises a first gas source connected in parallel with a lime powder silo, a lime powder blowing tank and a first injector, where a first cut-off valve is arranged between the lime powder blowing tank and the first injector; a second gas source connected in parallel with the biochar powder silo, the biochar powder blowing tank and the second injector, where a second cut-off valve is arranged between the biochar powder blowing tank and the second injector; a converter, where a plurality of bottom blowing lances are arrayed at a bottom of a converter, the bottom blowing lances are connected with the first injector and the second injector through a three-way valve, a third cut-off valve is arranged between the first injector and the three-way valve, and a fourth cut-off valve is arranged between the second injector and the three-way valve.
    Type: Application
    Filed: August 30, 2023
    Publication date: July 25, 2024
    Applicants: University of Science and Technology Beijing, Beijing Kemi Rongcheng Energy Technology Co., Ltd.
    Inventors: Kai DONG, Xin REN, Rong ZHU, Guangsheng WEI, Chao FENG, Rongfang SU, Shaoyan HU, Yun ZHOU, Chunyang WANG, Zhitao XUE, Linghui MENG
  • Publication number: 20240247329
    Abstract: A method by which an extremely low nitrogen concentration range can be stably reached in a short time without use of a top-blown gas is proposed. A molten steel denitrification method is a denitrification process in which CaO-and-Al2O3-containing slag formed by a combination of an Al addition step of adding a metal-Al-containing substance to molten steel to deoxidize and turn the molten steel into Al-containing molten steel and a CaO addition step of adding a CaO-containing substance to the molten steel is brought into contact with the Al-containing molten steel to remove nitrogen in the molten steel, in which the molten steel is stirred at a stirring power density ? of 60 W/t or higher. It is preferable that, in the denitrification process, a surface of the molten steel or the slag is subjected to an atmosphere of 1.0×105 Pa or lower. In a steel production method, the obtained molten steel is cast after the components are adjusted.
    Type: Application
    Filed: May 12, 2022
    Publication date: July 25, 2024
    Applicant: JFE STEEL CORPORATION
    Inventors: Hidemitsu NEGISHI, Rei YAMADA
  • Publication number: 20240247330
    Abstract: A slag conditioning agent for steel desulfurization is shown which is made by a process in which a dried slag material obtained from a secondary steelmaking process is mixed with quicklime particles. The quicklime particles react with moisture in the slag material to dry the slag material and produce a blend of slag material, hydrated lime and any unreacted quicklime. The blend is then sieved to separate out the hydrated lime. The retained dried fraction after sieving is then mixed with an Al2O3 mass fraction from which the slag conditioning agent can be collected. The slag conditioning agent has an equivalent mass ratio which is between 0.55 and 1.5.
    Type: Application
    Filed: February 7, 2024
    Publication date: July 25, 2024
    Applicant: S.A. Lhoist Recherche et Developpement
    Inventors: Eric Perrin, Souliyann Chunlamani
  • Publication number: 20240247331
    Abstract: The present invention relates to an austenitic stainless steel for high-pressure hydrogen gas or liquid hydrogen, having a composition consisting of: C?0.20 mass %, 0.10 mass %? Si?1.00 mass %, 0.10 mass %?Mn?2.0 mass %, P?0.050 mass %, S?0.050 mass %, 2.0 mass %?Cu<4.0 mass %, 8.0 mass %? Ni?11.5 mass %, 17.0 mass %<Cr?22.0 mass %, Mo?0.20 mass %, and N?0.050 mass %, with the balance being Fe and inevitable impurities; having an Ni equivalent Nieq of 24.0 or more; and having a relative reduction in area of 0.8 or more.
    Type: Application
    Filed: December 21, 2023
    Publication date: July 25, 2024
    Inventors: Daisuke KUDO, Nobuyuki TAKAHASHI, Tomohiro ANDO, Yoshihiko KOYANAGI
  • Publication number: 20240247332
    Abstract: A high-strength hot-rolled steel sheet according to the present invention has a specific chemical composition and a steel microstructure including, as main phases, 80% to 100% of martensite and bainite in terms of total area fraction. An entire area fraction of the martensite dispersed in the bainite is 2% to 20%. Among the martensite dispersed in the bainite, an area fraction of martensite each having an orientation difference of 15° or more between a crystal orientation of the martensite and a crystal orientation of at least one of bainite adjacent to the martensite is more than 50% relative to the whole martensite dispersed in the bainite. When regions surrounded by boundaries between adjacent crystals having an orientation difference of 15° or more are defined as crystal grains, an average aspect ratio of the crystal grains present in a region extending from a surface of the steel sheet to a depth of 5 ?m is 2.0 or less.
    Type: Application
    Filed: May 13, 2022
    Publication date: July 25, 2024
    Applicant: JFE Steel Corporation
    Inventors: Hiroshi Hasegawa, Hideyuki Kimura
  • Publication number: 20240247333
    Abstract: In determining the conditions for final annealing, information on the concentration of enriched components over the entire length and width of the steel sheet after decarburization annealing is obtained, the optimum function of product properties in the relationship between enriched components and control conditions for final annealing is obtained in advance, and the distribution of the control conditions for final annealing within the coil were considered while determining the control conditions for final annealing such that the area where the deviation of the product properties from the above optimum function is within a range of ±? is maximized over the entire length and width.
    Type: Application
    Filed: March 3, 2022
    Publication date: July 25, 2024
    Applicant: JFE STEEL CORPORATION
    Inventors: Makoto WATANABE, Takashi TERASHIMA, Takuya YAMADA
  • Publication number: 20240247334
    Abstract: The present invention provides a high value-added method for resource recovery from lithium sludge and fluoride sludge, and an economic sludge treatment method, wherein lithium fluoride (LiF), which is an insoluble lithium compound, is prepared by reacting lithium sludge with fluoride sludge, and then Li—Al layered double hydroxide (LI-Al LDH), which is an insoluble lithium compound, is prepared by reacting reaction filtrate with an aluminum compound, after which a conversion product is prepared by a sulfation reaction of the Li—Al layered double hydroxide (LI-Al LDH), which is an insoluble lithium compound, with a sulfuric acid compound, a lithium concentrate is prepared by leaching the conversion product with water, and then the lithium concentrate is recirculated as a lithium raw material to efficiently and economically recover lithium ions contained in the lithium sludge, or lithium fluoride (LiF) is prepared, and then lithium ions and fluoride ions are economically recovered from lithium sludge and fluor
    Type: Application
    Filed: July 4, 2022
    Publication date: July 25, 2024
    Inventors: Taegong RYU, Junho SHIN, Jae-Min JEONG
  • Publication number: 20240247335
    Abstract: A method, apparatus and system for processing a composite waste source, such as e-waste, is disclosed. The composite waste source may comprise low-, moderate and high-melting point constituents, such as plastics, metals and ceramics. The composite waste source is heated to a first temperature zone, causing at least some of the low-melting point constituents to at least partially thermally transform. The composite waste source is subsequently heated to a second, higher, temperature zone, causing at least some of the moderate-melting point constituents to at least partially thermally transform. At least some of the at least partially thermally transformed constituents may be recovered. The method, apparatus and system disclosed may provide for the recovery and reuse of materials which would otherwise be sent to landfill or incinerated.
    Type: Application
    Filed: January 24, 2024
    Publication date: July 25, 2024
    Inventor: Veena Sahajwalla