Abstract: Systems and methods for determining the health status of a retina of a subject. An optical coherence tomography (OCT) volume image of a retina of a subject may be received. A health indication output is generated, via a deep learning model, using the OCT volume image. The health indication output indicates a level of association between the OCT volume image and a selected health status category for the retina. A map output for the deep learning model is generated using a saliency mapping algorithm, generating a map output for the deep learning model using a saliency mapping algorithm. The map output indicates a level of contribution of a set of regions in the OCT volume image to the health indication output generated by the deep learning model.

Abstract: An ECG measurement node for a patient electrode is provided, including an electrode interface and ECG processing circuitry electrically coupled to the electrode interface. The electrode interface is electrically and removably coupled to the patient electrode. The patient electrode is affixed to a patient. The ECG processing circuitry is configured to generate an ECG signal. The ECG measurement node further includes a transceiver configured to wirelessly transmit the ECG signal or a fiber optic interface configured to transmit the ECG signal via a fiber optic link. An ECG measurement network is also provided, including a first and second ECG measurement node. The first ECG measurement node and the second ECG measurement node are communicatively coupled to a patient monitor. The ECG measurement network may further include a central access point communicatively coupled to the first ECG measurement node, the second ECG measurement node, and the patient monitor.

Abstract: A method of determining a condition of a subject comprises receiving functional magnetic resonance (MR) data and structural MR data, each describing the brain of the subject. A subject-specific functional connectome (FC) is constructed using the functional MR data, and a subject-specific structural connectome (SC) is constructed using the structural MR data. A convolutional neural network (CNN) is fed with the subject-specific FC and SC. The CNN has a first set of layers that separately process the subject-specific FC and SC, and a second set of layers that process combined outputs from the first set of layers. An output indicative of the condition of the subject is received from the second set of layers of the CNN.

Abstract: One or more aspects of the technical solutions described herein facilitate using transdermal infrared optics to discover infraspectral markers. The infraspectral markers can predict presence/absence of one or more physiological state in a subject. One or more aspects of the technical solutions described herein further facilitate continuous monitoring and prediction of trends of a physiological state of a subject using non-invasive transdermal infrared optics. Further, one or more aspects of the technical solutions described herein facilitate personalized triage of and alerts for a subject based on continuous monitoring of non-invasive transdermal optical infraspectral markers.

Abstract: The present disclosure relates to methods and compositions for detecting circulating tumor cells (CTCs) using a compound comprising a targeting moiety and a fluorescence imaging agent.

Abstract: A method of visualizing bacteria in real time includes positioning a portable frame of a portable imaging system relative to a target, wherein the portable imaging system includes a camera and an excitation light source mounted on the portable frame, operating the portable imaging system in a hands-free manner to illuminate the target with excitation light having at least one wavelength to cause at least one biomarker associated with the target to fluoresce and to detect fluorescence of the at least one biomarker with the camera.

Abstract: A device and method for rescaling a signal to remove an absorption offset from an optical measurement. During a first mode a scaling factor is obtained from measurements on a reference object which is then applied during a second mode when measuring on a measurement object.

Abstract: A photoacoustic and ultrasonic imaging device includes a laser light source configured to generate a laser, an ultrasonic wave source configured to generate an ultrasonic wave generation signal, an imaging probe including a laser emitter configured to receive the laser and emit the laser to a target and an ultrasonic transducer configured to receive the ultrasonic wave generation signal, emit an ultrasonic wave to the target, and detect a photoacoustic signal and an ultrasonic signal generated and reflected from the target, and an operation unit configured to form an image of tissue in the target from the laser and an image of the tissue in the target from the ultrasonic wave on the basis of the photoacoustic signal and the ultrasonic signal detected by the ultrasonic transducer.

Abstract: An exemplary system and method are disclosed that employ a wireless, fully integrated, soft sternal patch to capture PPG signals from the sternum, an anatomical region that exhibits a robust vasoconstrictive response while also providing a convenient sternal location for the integration of electrocardiography and seismocardiography sensors in a single, all-in-one device capable of multifaceted human health monitoring. With healthy control subjects, the device is is configured to detect vasoconstriction induced endogenously through controlled breathing exercises and exogenously through changes in ambient temperature. Furthermore, in overnight trials with sleep apnea patients, the device shows a high agreement in vasoconstriction detection with a commercial system, demonstrating its potential use in continuous, long-term vasoconstriction monitoring.

Abstract: An arrangement for measuring a flow velocity in a blood vessel comprising; a catheter configured to be inserted into a blood vessel; a plurality of flow velocity sensors coupled to the catheter; a sensor network coupled to the plurality of flow velocity sensors; and a processor coupled to the sensor network; wherein each of the plurality of flow velocity sensors is configured to sense a velocity of a blood flow, wherein an output of the sensor network is configured to be input into a mathematical model stored in the processor, and wherein the mathematical model is configured to calculate the flow velocity in the blood vessel where the catheter is located.

Abstract: The application includes a coronary diagnostic assembly, the wire guide of which serves both to measure transstenotic pressures for a fractional flow reserve (FFR), by means of the pressure sensor integrated into the wire guide, and to perform cardiac pacing during said FFR measurement.

Abstract: A method for monitoring a cardiovascular pressure in a patient includes measuring, by pressure sensing circuitry of an implantable pressure sensing device, the cardiovascular pressure of the patient. The method further includes transmitting, via wireless communication circuitry of the implantable pressure sensing device, the measured cardiovascular pressure to another device. The method further includes determining, by processing circuitry of the other device, whether a posture of the patient at a time of the measured cardiovascular pressure was a target posture for cardiovascular pressure measurements. The method further includes determining, by the processing circuitry of the other device, whether to store or discard the transmitted cardiovascular pressure based on determining whether the posture was the target posture.

Abstract: An electronic sphygmomanometer with integrated air pump and a control method thereof are provided, wherein the electronic sphygmomanometer includes a main body and a sleeve that are detachably coupled to each other, the main body has a master controller with Bluetooth chip integrating: a Bluetooth communication module, for having two-way data connection with a mobile terminal and sending instructions related to blood-pressure measurement to a Bluetooth control module; and the Bluetooth control module, for executing control and data processing tasks in response to the received instructions. In a first measurement stage, the Bluetooth communication module regularly sends dynamic air pressure values to the mobile terminal; and in a second measurement stage, the Bluetooth communication module associates blood pressure values, calculated by the Bluetooth control module, with heart rate values to form a Bluetooth data set and sends to the mobile terminal.

Abstract: Apparatus and methods are described including deriving a subject's heart rate from in-phase and the quadrature signals received by a radar. The in-phase and quadrature signals are processed to generate two or more outputs using two or more respective methods. For each of the two or more outputs, for each of a plurality of time segments, the subject's heart rate is derived from the filtered signal, and quality scores are assigned to the subject's heart rate as derived for each of the plurality of time segments from each of the two or more outputs. At least partially based upon the quality scores, the subject's heart rate is derived using the output of one of the methods. Other applications are also described.

Abstract: A system and method for a multi-function remote ambulatory cardiac monitoring system. The system includes a housing and a microprocessor disposed within the housing. The microprocessor controls the remote ambulatory cardiac monitoring system. The system also includes an electrode for sensing ECG signals and the electrode being in communication with the microprocessor. An integrated cellular module also is included in the system, and the cellular module is connected to the microprocessor and disposed within the housing. The integrated cellular module transmits ECG signals to a remote center.

Abstract: A method for reconstructing dynamic contrast-enhanced (DCE) MR images includes receiving a plurality of continuous free-breathing DCE images, the plurality of images obtained with a contrast, sorting the images by identifying a respiratory phase associated with each of the continuous free-breathing DCE images, reconstructing the plurality continuous free-breathing DCE images into a 4D respiratory motion-resolved image, obtaining 3D deformable motion vector fields (MVFs), and utilizing a deep learning based motion transformation integrated forward-Fourier (DL-MOTIF) model and the 3D deformable MVFs to reconstruct the DCE MR images.

Abstract: The present disclosure provides a system for MRI. The system may obtain a plurality of auxiliary signals and a plurality of imaging signals collected by applying an MRI pulse sequence simultaneously to a plurality of slice locations of a subject. For each of at least one target slice location of the plurality of slice locations, the system may generate at least one target image of the target slice location based on the plurality of auxiliary signals and the plurality of imaging signals. During the application of the MRI pulse sequence, phase modulation may be applied to at least one of the plurality of slice locations so that the plurality of slice locations have different phases during the readout of at least one of the plurality of imaging signals.

Abstract: A stimulation electrode assembly configured to be positioned relative to a patient for an operative procedure is disclosed. An evoked stimulation response may be sensed by a sensor near a portion of a subject. The evoked response may be sensed by an electrode and determined with a monitoring system. The evoked response may additionally and/or alternatively be sensed with a motion sensor. A position sensor may be provided to measure or determine whether the sensor has moved during a procedure.

Abstract: A patient monitoring system includes a first sensor that monitors patient movement, a second sensor that monitors an area for a presence, and a remote monitoring terminal. An alarm is generated at the remote monitoring terminal when both the first sensor and the second sensor respectively detect the patient movement and the presence.

Abstract: A system for monitoring individuals includes sensors configured to collect data over a period of time. The data is associated with physical characteristics and behavioral characteristics of an individual in a room over the period of time. A processor is in communication with the sensors and coupled to an artificial intelligence processor device, which learns the physical characteristics and behavioral characteristics and defines therefrom normal physical characteristics and normal behavioral characteristics for the individual. The processor can compare physical characteristics and behavioral characteristics of the individual associated with other data, collected over another period of time from the sensors, with the normal physical behavioral characteristics and provide a report of the comparison.

Abstract: A system for capturing information related to an aspect associated with an aerosol-generating device is provided, the aspect comprising at least one of a user aspect and a consumable aspect, the system including: a signal capture system including one or more acoustic actuators configured to generate an acoustic signal and including a button, and an acoustic sensor, the one or more acoustic actuators and the acoustic sensor being located at predetermined locations with respect to the aerosol-generating device such that an acoustic signal generated by pressing the button is modulated at least in part according to the aspect before being detected by the acoustic sensor, thereby capturing the information related to the aspect.

Abstract: A fully autonomous system is used to diagnose an ear infection in a patient. For example, a processor receives patient data about a patient, the patient data comprising at least one of: patient history from medical records for the patient, one or more vitals measurements of the patient, and answers from the patient about the patient's condition. The processor receives a set of biomarker features extracted from measurement data taken from an ear of the patient. The processor synthesizes the patient data and the biomarker features into input data, and applies the synthesized input data to a trained diagnostic model, the diagnostic model comprising a machine learning model configured to output a probability-based diagnosis of an ear infection from the synthesized input data. The processor outputs the determined diagnosis from the diagnostic model. A service may then determine a therapy for the patient based on the determined diagnosis.

Abstract: An analyte sensor system may include a first communication circuit configured to transmit a wireless signal in a first communication mode and a second communication mode, and a processor, wherein the processor determines whether a first condition is satisfied, the first condition relating to the sensor signal or to communication by the first communication circuit, and shifts the system to a second communication mode responsive to the first condition being satisfied.

Abstract: Provided are a method, system and computer-readable storage medium for quantitative physiological assessment and prediction of clinical subtypes of glucose metabolism disorders, including but not limited to, Type 1 diabetes, obesity, pre-diabetes, gestational diabetes, or variants of Type 2 diabetes. The method allows a virtual population of in silico entities to be created, reproducing faithfully the clinical subtype distributions observed in vivo. Potential applications of this method may include, but are not limited to: (a) enabling in silico experiments assessing and/or predicting, for a real patient, treatment or intervention outcomes for a given population/clinical-subtype level; (b) pre-clinical testing of properties of new medications; (c) augmenting limited clinical trial data with in silico experiments to an extent that the domain of their validity and test corner cases may not be observed in vivo.

Abstract: Blood glucose states based at least on sensed brain activity data. Blood glucose states may be predicted states using prediction models, and may be real-time or future glucose states. One or more wearable sensors, optionally adapted for use in either single channel or dual channel sensing, can record brain activity signals and communicate brain activity signal data to a remote device.

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from the same tissue site. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus. The multi-sensor apparatus can orient the plurality of non-invasive, physiological sensors such that each of the plurality of non-invasive, physiological sensors obtains physiological data from the same or a similar location.

Abstract: Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.

Abstract: Various examples are directed to systems and methods for measuring a parameter related to patient health. An analyte sensor system may detect that the analyte sensor system has been applied to a host and may store analyte data describing the host. The analyte sensor system may determine that sensor use at the analyte sensor system has terminated and upload stored analyte data to an upload computing device.

Abstract: The present disclosure relates to a sensor member for continuous blood glucose measurement, wherein a first electrode layer and a second electrode layer are laminated to be misaligned from each other in the process of forming an electrode layer of the sensor member for continuous blood glucose measurement, so that an electrical contact phenomenon between the first electrode layer and the second electrode layer, which may occur in the process of cutting both side surfaces of the sensor member in the widthwise direction, is prevented, and accordingly, product defects are prevented and the stability of the sensor performance is improved.

Abstract: A multi-composite electrochemical cell substantially consists of a thin polymer membrane including three different adjacent sectors, which are made of the same appropriately seamlessly modified polymer, incorporating in the polymer one or more conductive phases, or conductive fillers, such as graphene, metal, or a combination thereof. In the first sector the polymer material incorporates graphene nanoplatelets and acts as a cathode; in the second sector, interposed between the other two, the polymer material acts as an insulating spacer; in the third sector the polymer material incorporates graphene nanoplatelets and a metal filler or immersed metal contact rheophore, with negative standard reduction potential, and acts as an anode; wherein the metal filler is in the form of dispersed powder or dispersed flakes, or of a thin sheet incorporated in the polymer.

Abstract: The present disclosure describes a multi-analyte sensor system that detects wear location. The system includes a first sensor, a second sensor, a memory, and a processor communicatively coupled to the memory. The first sensor produces a first signal stream indicating a level of a first analyte, and the second sensor produces first physiological data. The processor determines, based on the first signal stream and the first physiological data, a wear location of the first sensor and makes an adjustment related to at least one of the first sensor or the first signal stream based on the wear location of the first sensor.

Abstract: A device for obtaining a blood sample may include a holder for receiving a sample source, the holder having an actuation portion and a port; a container engagement portion connected to the holder; and a collection container removably connectable to the container engagement portion, the container defining a collection cavity, wherein the actuation portion comprises at least two wings that are angled relative to a patient's finger held in the holder to create a pressure gradient towards a fingertip of the patient's finger.

Abstract: A device for obtaining a blood sample may include a collection container defining a cavity to receive the blood sample; and an adaptor defining a cavity to receive the collection container, wherein the adaptor comprises retention features to orient the collection container into a desired position when inserted into the adaptor.

Abstract: A device for collecting blood, comprising: a tubular member having a diameter D1 enclosing an interior volume having a rated capacity, a distal end of the tubular member provided with a tip having a first through-hole in fluid communication with the interior volume, a proximal end of the tubular member provided a second through-hole in fluid communication with the interior volume; a cap formed of a self-healing material and configured to seal the tip of the tubular member; and a plunger movably accommodated within the interior volume of the tubular member, the plunger including an elongate member having an enlarged pad provided on a proximal end, an elastomeric member provided on a distal end and one or more locking wing members provided on and biased to extend away from the elongate member; wherein when the plunger is retracted to the rated capacity, the one or more locking wing members extend beyond the interior volume and engage with the proximal end of the tubular member.

Abstract: An automated data acquisition, appraisal and analysis in noninvasive rapid screening of neuro-otologic condition using combination of subject's objective oculomotor, vestibular and reaction time analytic variables, comprises the steps of: establishing an oculomotor, vestibular and reaction time testing protocol for specific neuro-otologic condition which protocol included eye tracking aspects and which protocol obtains a combination of a subject's objective oculomotor, vestibular and reaction time analytic variables; coupling an eye tracker to subject; automatically establishing a region of interest for the eye tracker in which the region of interest is centered on the subject's pupils; conducting the oculomotor, vestibular and reaction time testing protocol using pre-programmed/automated voice instructions to the subject to obtain a combination of a subject's objective oculomotor, vestibular and reaction time analytic variables; and calculating and displaying a normalized composite test protocol score (0-1)

Abstract: The present application discloses a deception detection systems and processes that use a processor; an eye tracking device connected to the processor, and a set of physiological sensors connected to the processor. The eye tracking device may comprise an infrared camera that is positioned to be able to track the oculomotor activity of a subject. The deception detection system also includes a respiratory sensor connected to the processor positioned to be able to track the respiration of the subject and an electrodermal sensor connected to the processor positioned to be able to detect the electrodermal activity of the subject. Additionally, the deception detection system includes a cardiovascular sensor connected to the processor positioned to be able to detect the cardiovascular activity of the subject and a speaker connected to the processor positioned to be able to transmit sound to the subject.

Abstract: A wearable heat stress monitor (100) comprising: a first sensor (110). the first sensor (110) comprising an electrode (115) for sensing a sweat parameter (110A) and at least one further sensor (120) for sensing a body parameter or an environmental parameter (120A). The heat stress monitor (100) further comprises a processor (130) to determine a heat stress level based on the sweat parameter (110A) sensed by the first sensor (110) and the body parameter or environmental parameter (120A) sensed by the at least one further sensor (120) and an output module (140) for outputting information based on the heat stress level determined by the processor (130).

Abstract: A sample collection device includes an inlet, a waste chamber having a waste chamber opening, a collection chamber having a collection chamber opening, and a toggling mechanism configured to select between a first fluid path from the inlet to the waste chamber via the waste chamber opening, and a second fluid path from the inlet to the collection chamber via the collection chamber opening.

Abstract: A bipolar stimulation probe includes a first electrode, a second electrode, a control module, and switches. The control module is configured to stimulate nerve tissue of a patient by generating (i) a first output signal indicative of a first pulse to be output from the first electrode, and (ii) a second output signal indicative of a second pulse to be output from the second electrode. The first pulse and the second pulse are monophasic. The switches are configured to output from the bipolar stimulation probe (i) the first pulse on the first electrode based on the first output signal, and (ii) the second pulse on the second electrode based on the second output signal.

Abstract: A helmet-like medical diagnostic apparatus that is fixed or worn has motorized gimbals that automatically swivel to positions around a patient's head. An end effector extends radially from the gimbals toward the head to place a coil or other directional sensor snugly against the scalp. A coil sensor can be part of a sensitive circuit to measure eddy currents within the brain. Accelerometers, or other tilt-measuring gauges, are compared between those on the sensor and those on the apparatus's base to determine the precise 3D orientation of the sensor when resting against the head. The orientation can compensate coil measurements, find an exact spot again, or map opposing sides of the patient's cranium, even with a fidgeting unconscious patient. The head can be scanned in its entirety, or a spot scan may be prompted from other diagnostic data.

Abstract: A bio-electrode includes a porous, stretchy base material, an adhesive, conductive film containing silicon, and a conducting path. The conductive film is formed on one surface of the porous, stretchy base material. The conducting path is connected to the conductive film, and penetrates the stretchy base material to be exposed on the opposite side. This enables provision of the bio-electrode that has high sensitivity to a bio-signal and excellent bio-compatibility, that is lightweight, that can be produced at low cost, that is free of itching, red spots, and rash of the skin and comfortable even when being wet, dried, or attached to the skin for a long period of time, without a significant decrease in sensitivity to the bio-signal, a production method for the bio-electrode, and a measurement method for a bio-signal.

Abstract: Various systems and methods for managing disposable sensors and electrode gel are disclosed. According to an embodiment, a sensor assembly configured to be attached to a patient includes one or more electrode modules. Each of the one or more electrode modules includes an electrode, electrode gel disposed in a storage location on the electrode module, wherein electrode gel is not in contact with the electrode in the storage location, and a deformable cap configured to move the electrode gel from the storage location into contact with the electrode in response to a deformation of the deformable cap.

Abstract: Blood glucose states based at least on sensed brain activity data. Blood glucose states may be predicted states using prediction models, and may be real-time or future glucose states. One or more wearable sensors, optionally adapted for use in either single channel or dual channel sensing, can record brain activity signals and communicate brain activity signal data to a remote device.

Abstract: In some embodiments, the present invention provides an exemplary inventive system that includes: an apparatus to record: individual's brain electrical activity, a physiological parameter of the individual, and iii) an environmental parameter; a computer processor configured to perform: obtaining a recording of the electrical signal data; projecting the obtained recording of electrical signal data onto a pre-determined ordering of a denoised optimal set wavelet packet atoms to obtain a set of projections; normalizing the particular set of projections of the individual using a pre-determined set of normalization factors to form a set of normalized projections; determining a personalized mental state of the individual by assigning a brain state; determining a relationship between: the physiological parameter, the environmental parameter, and the personalized mental state; generating an output, including: a visual indication, representative of the personalized mental state, and) a feedback output configured to af

Abstract: Embodiments are directed to an electronic device having integrated sensors for detecting a user's cardiac electrical signals. The device can include a heart sensor having several leads for detecting a user's cardiac signals. The leads can be coupled to interior surfaces of the device housing to hide the sensor from view, and electrical signals generated by the user can be transmitted from the user's skin through the electronic device housing to the leads. In some embodiments, leads can be coupled to the exterior of the housing. The device can be finished so that the pads are integrated with the device to improve aesthetic qualities of the device. The electronic device can use the cardiac signals to identify or authenticate the user and perform operations based on the identity of the user. In some embodiments, the electronic device can provide data related to the user's mood based on the cardiac signals.

Abstract: Wrist-wearable apparatuses that may be removed and used as a chest-applied cardiac device may include two chest electrodes on an inner surface of a strap (or strap regions), as well as two finger or more finger electrodes on the opposite side of the apparatus. The apparatus may be removed from the wrist and placed on a chest of a patient such that two electrodes are spaced at least five centimeters apart and in contact with the chest and held in place with two or more fingers to capture orthogonal cardiac signals that may be synthesized into a conventional 12-lead cardiac signal.

Abstract: A multi-label electrocardiogram (ECG) signal classification method based on an improved attention mechanism is provided. A model is constructed for classifying a multi-label (multi-lead) ECG signal. The model has a strong ECG data learning ability, allowing a computer to fully extract a feature of the ECG signal and construct a data processing channel model. Therefore, the multi-label (multi-lead) ECG signal can be effectively classified, improving the accuracy and precision of classification.

Abstract: A system for surgical imaging is disclosed. The system utilizes imaging devices configured to be inserted into a body of a patient. The system includes a display device, a first catheter having a first transducer. The first transducer is configured to sense an anatomical structure of the body and output a first set of imaging data. The system includes a second catheter having a second transducer configured to sense the anatomical structure and output a second set of imaging data. The system includes a processor in communication with a memory storing executable instructions. The system receives, simultaneously, the first set and second set of imaging data. The system determines positions of the anatomical structures, based on the first and second set of imaging data. The system displays, on the display device, a real-time rendering of the anatomical structure based on the position of the anatomical structure.

Abstract: Neurofeedback training can include a subject visualizing a mental image, neural signals that quantify visual working memory related to the mental image can be recorded using scalp electrodes. The subject's performance with the visualization can be scored based on neural activity related to a cognitive function within the neural signals during an induction period. Feedback can be provided to the subject based on the scoring to inform the subject of a success rate related to the visual working memory. The goal of the neurofeedback training can be to improve the subject's cognitive function.

Abstract: Disclosed herein are compositions and methods for use in conjunction with assessment of facial wrinkles related to tendon repair. Embodiments disclosed herein can assess facial wrinkles using artificial intelligence platform.