Patents Issued in September 12, 2024
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Publication number: 20240301308Abstract: Various embodiments of a process for converting light alkanes to diesel are disclosed. In general, the process includes reacting a feed rich in one or more light alkanes with an aromatization catalyst to convert the light alkanes to aromatic hydrocarbons, reacting the aromatic hydrocarbons with a hydroalkylation catalyst to convert the aromatic hydrocarbons into diesel range hydrocarbons, and hydrogenating the diesel range hydrocarbons to produce a diesel product.Type: ApplicationFiled: March 8, 2024Publication date: September 12, 2024Inventors: Jianhua Yao, Kening Gong, Huanxin Gao, Jiangang Lyu, Feng Xu, Wennian Wang, Ming Xu, Yilun Wei
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Publication number: 20240301309Abstract: A nanostructure includes a plurality of substantially spherically curved carbon layers having diameters in a range of 1 nanometer to 1000 nanometers and a plurality of halogen atoms attached to an outer convex side of the carbon layers. A composition of matter includes a liquid fuel and an additive including at least one liquid and a plurality of carbon nano-onions. A method of fabricating an additive for liquid fuel includes creating a carbon-based material using a plasma in an environment including at least one hydrocarbon gas and/or at least one liquid containing hydrocarbons, organometallic metal-complex, and/or element-organic compounds, evaporating organic material from the carbon-based material, halogenating the carbon-based material, and extracting carbon nano-onions from the halogenated carbon-based material.Type: ApplicationFiled: February 14, 2024Publication date: September 12, 2024Inventors: Ievgen Polunkin, Jacek Bogdan Jasinski, Dmytro Vinnichenko, Kirill Gichunts
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Publication number: 20240301310Abstract: The present invention provides a solid addition-type diesel environmental protection anti-smoke additive and a method for preparing the same. The additive includes a solvent, vinyl ferrocene, and vinyl acetate. The method includes the following steps: under the condition that nitrogen is introduced to completely replace air, adding to a high-pressure reactor the solvent, vinyl ferrocene, vinyl acetate, and a free radical initiator; starting stirring to introduce a high-pressure vinyl monomer; polymerizing and synthesizing a free radical into a crude product of a diesel anti-smoke oxidant; under the condition of the constant temperature of a system, completing reaction when a pressure is not changed for 60 min; cooling down a reaction product to a room temperature and releasing the pressure to an atmospheric pressure to obtain the crude product; and performing atmospheric distillation for the crude product to remove a petroleum ether and an unreacted raw material from the crude product.Type: ApplicationFiled: March 9, 2023Publication date: September 12, 2024Inventor: Ruixue Zhang
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Publication number: 20240301311Abstract: The use of a nitrate compound and/or a peroxide compound as an additive in a diesel fuel composition to reduce the impact of deposits in the post combustion system of a diesel engine when combusting said diesel fuel composition.Type: ApplicationFiled: September 23, 2022Publication date: September 12, 2024Inventor: Philip John BOON
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Publication number: 20240301312Abstract: A combustion-supporting package structure includes a main body, gas channels, and a ventilation duct. An ignition member is arranged below the main body, the gas channels are provided inside a bottom end of the main body, the ventilation duct is provided in a middle of the bottom end of the main body, charcoal is arranged above the main body, an end cover is arranged above the charcoal, a placing cavity is provided inside a top end of the end cover, and ventilation holes are provided inside the top end of the end cover at a front end and a rear end of the placing cavity. A stainless steel clip is arranged above the end cover. According to the combustion-supporting package structure, thermal convection is generated in the gas channels, such that the charcoal is continuously and stably burn, and a combustion-supporting gas enters the main body through the ventilation duct.Type: ApplicationFiled: March 12, 2024Publication date: September 12, 2024Applicant: Zhejiang Tanfu New Energy Co., Ltd.Inventors: Qi ZHOU, Yi LIU, Jinming ZHAO, Weilin FANG
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Publication number: 20240301313Abstract: Spent potlining material contains spent potliner from aluminium electrolysis cells, and at least one hydrophobic binder. The hydrophobic binder being selected from wax, a waxlike compound or mixtures thereof. A method for producing a spent potlining material includes the steps of (a) providing spent potliner from aluminium electrolysis cells, (b) comminuting the spent potliner in at least one comminuting apparatus, (c) fractionating the spent potliner through a separating apparatus, (d) mixing the spent potliner with at least one hydrophobic binder, selected from wax, a waxlike compound or mixtures thereof, in a mixing apparatus, (e) portioning the mixture obtained in step (d), (f) withdrawing the spent potlining material The steps (b) to (d) are carried out in an inert gas atmosphere. Also, spent potlining material is used as fuel in power stations and also in connection with the production of mineral wool, cement and steel.Type: ApplicationFiled: May 17, 2024Publication date: September 12, 2024Applicant: Speira GmbHInventors: Ralf Lemke, Olaf Güßgen, Kathrin Eckhard, Joachim Höfler, Andreas Beermann, Thorsten Kensy
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Publication number: 20240301314Abstract: A lubricating oil composition for internal combustion engines, including: (A) a lubricating base oil; and (B) a metal-based detergent, wherein the component (B) contains: (B1) a calcium-based detergent in which a content of calcium based on a total mass of the composition is within a specific range; and (B2) a magnesium-based detergent in which a content of magnesium based on the total mass of the composition is within a specific range, the component (B1) contains (B1-1) a calcium-based detergent containing boron and calcium, a content of boron based on the total mass of the composition is 1000 mass ppm or less, a ratio (B(B1)/Ca(B1)) of B(B1) to Ca(B1) is 0.15 or more and 0.35 or less, and a ratio (B(B1)/[Ca(B1)+Mg(B2)]) of B(B1) to a total amount (Ca(B1)+Mg(B2)) of Ca(B1) and Mg(B2) is 0.13 or more and 0.29 or less.Type: ApplicationFiled: January 27, 2022Publication date: September 12, 2024Applicant: ENEOS CORPORATIONInventor: Shogo ERYU
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Publication number: 20240301315Abstract: Heat transfer fluids corresponding to mixtures of at least one hydrogen bond donor and at least one hydrogen bond acceptor are provided. The heat transfer fluids can have an unexpectedly high heat capacity relative to the expected heat capacity based on the heat capacities of the at least one hydrogen bond donor and the at least one hydrogen bond acceptor. In some aspects, the heat transfer fluids can also have a sufficiently high electrical resistivity to be suitable for use in environments such as heat management systems in electric vehicles.Type: ApplicationFiled: March 21, 2022Publication date: September 12, 2024Applicant: EXXONMOBIL TECHNOLOGY AND ENGINEERING COMPANYInventors: Abigail R. VAN WASSEN, Andrew E. TAGGI, Shuji LUO, Gary CHRISTENSEN, Kevin J. KELLY, Andrew D. SATTERFIELD
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Publication number: 20240301316Abstract: The present invention relates to a lubricating composition comprising: water, especially purified water, for example ultrapure water, demineralized water, osmotic water, deionized water; glycerol; nanosheets of h-MoS2, wherein the active content of h-MoS2 nanosheets is comprised between 0.01 and 0.07 wt %, preferably between 0.02 to 0.06 wt %, based on the total weight of the lubricating composition, wherein, the nanosheets of h-MoS2 are obtained in-situ in the lubricating composition by liquid-phase exfoliation of bulk MoS2 particles water.Type: ApplicationFiled: June 30, 2022Publication date: September 12, 2024Applicants: TotalEnergies OneTech, ECOLE CENTRALE DE LYON, Centre national de la recherche scientifiqueInventors: Benoit THIEBAUT, Virginia RUIZ FERNÁNDEZ, Ignacio GARCÍA ALONSO, Andi MIKOSCH CUKA, Fabrice DASSENOY
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Publication number: 20240301317Abstract: To provide a method for separating and quantifying saturated and unsaturated dialkyl ketones. (1) A method for separating and quantifying saturated and unsaturated dialkyl ketones, the method including quantifying a dialkyl ketone-containing sample by a gas chromatograph using a polar column, except a nonpolar column and a slightly polar column, the polar column having a polarity value of 440 or greater. (2) The method according to (1), wherein the polar column is a polar column with medium polarity or higher polarity, the polar column having a polarity value of 700 or greater. (3) The method of (2), wherein the polar column is a polar column with high polarity or higher polarity, the polar column having a polarity value of 1550 or greater. (4) The method according to (3), wherein a liquid phase of the polar column with high polarity or higher polarity is an ionic liquid column.Type: ApplicationFiled: June 30, 2022Publication date: September 12, 2024Applicant: FUJI OIL HOLDINGS INC.Inventors: Yutaka KATO, Shimpei WATANABE
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Publication number: 20240301318Abstract: The present invention relates to a process for increasing the oxidative stability of short path evaporated oils, by adding to short-path evaporated treated oil at least one other oil. It further relates to a composition comprising short-path evaporated treated palm oil and, at least one other oil. Furthermore, it relates to the food products comprising these oils with improved oxidative stability.Type: ApplicationFiled: March 10, 2023Publication date: September 12, 2024Applicant: CARGILL, INCORPORATEDInventor: Falk BRUESE
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Publication number: 20240301319Abstract: The present disclosure provides fragrance compositions having an olfactive profile that changes with time. The fragrance compositions include at least two contrasting perfume accords. The at least two contrasting perfume accords provide an olfactory modulating effect, such that the fragrance compositions deliver a desirable scent with increased perceived intensity and improved longevity of perception.Type: ApplicationFiled: May 20, 2024Publication date: September 12, 2024Inventors: Nicholas O'LEARY, Addi FADEL, Jeffrey DUNDALE, Robert KNAB
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Publication number: 20240301320Abstract: The present disclosure related generally to a process for removing chloride-containing organic compounds from renewable and bio-feedstocks. Accordingly, in one aspect, the present disclosure provides for a process for processing a liquid feed, the process comprising: providing a liquid feed that comprises one or more fatty acids and/or fatty acid esters, the liquid feed having a first chloride concentration by weight of chloride-containing organic compounds; and contacting the liquid feed with a solid treatment material to remove at least a fraction of the chloride-containing organic compounds to produce a treated liquid feed having a second chloride concentration that is less than the first chloride concentration, wherein the solid treatment material comprises an alkali metal or an alkaline earth metal in ionic form.Type: ApplicationFiled: June 29, 2022Publication date: September 12, 2024Inventors: Velu Subramani, Zhaorong Zhang, Zhuoran Xu, Renzy Lewis Stepp, Robert Cherian Abraham, Vincent Kispersky, Kevin Thacker, John Shabaker
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Publication number: 20240301321Abstract: A composition for a candle which is characterized in that it includes, in percent by weight: from 0 to 40% of at least one fatty alcohol, from 3 to 10% of at least one volatile alkane whose flash point is less than 180° C., from 0 to 3% of at least one wax, from 0 to 3% of at least one mixture of unsaponifiables, and from 47 to 95% of at least one at least partially hydrogenated vegetable oil.Type: ApplicationFiled: August 3, 2021Publication date: September 12, 2024Applicant: BIOSYNTHISInventor: Thierry BERNOUD
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Publication number: 20240301322Abstract: Novel bio-based surfactant derivatives with enhanced pH stability are provided, as well as their use in various consumer products. Methods of producing these surfactant derivatives are also provided.Type: ApplicationFiled: February 15, 2024Publication date: September 12, 2024Inventors: Lee SPEIGHT, Andrew MORRIS, Charbel CHERFAN, Daniel HAGAMAN
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Publication number: 20240301323Abstract: A detergent composition including (a) at least one acyl alkyl isothionate surfactant of formula (I): wherein R1 represents an optionally substituted C4-C36 hydrocarbyl group; each of R2, R3, R4 and R5 independently represents hydrogen or a C1-C4 alkyl group and wherein at least one of R2, R3, R4 and R5 is not hydrogen; and M+ represents a cation; and (b) at least one hydrocarbyl saccharide compound.Type: ApplicationFiled: March 1, 2024Publication date: September 12, 2024Inventors: Delia Galindo, Stephen Moss O'Connor, Maurizio Peroni, Alessandra Andreoli
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Publication number: 20240301324Abstract: The present invention relates to the use of a combination of a sophorolipid surfactant and an zwitterionic surfactant selected from the group consisting of betaines and hydroxysultaines in a composition to improve the mildness to skin of the composition by reducing the amount of zein protein solubilised by the composition, measured as described herein, wherein the composition comprises an anionic surfactant. The invention also relates to a method of reducing the amount of zein protein solubilised by a composition comprising an anionic surfactant, the method comprising the steps of: a) including a sophorolipid surfactant in the composition; and b) including a zwitterionic surfactant selected from the group consisting of betaines and hydroxysultaines in the composition; wherein the amount of zein protein solubilised by the composition is reduced by at least 20 wt %, measured as described herein.Type: ApplicationFiled: August 5, 2022Publication date: September 12, 2024Applicant: Croda International PlcInventors: Katy HELM, Heather CLARKSON, Timothy A. MILLER
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Publication number: 20240301325Abstract: The disclosure relates to poly alpha-1,6-glucan ether compounds comprising poly alpha-1,6-glucan substituted with at least one positively charged organic group and having a degree of substitution of about 0.001 to about 3.0. The poly alpha-1,6-glucan comprises a backbone of glucose monomer units wherein greater than or equal to 40% of the glucose monomer units are linked via alpha-1,6 glycosidic linkages, and optionally about 3% of the backbone glucose monomer units have branches via alpha-1,2 and/or alpha-1,3 glycosidic linkages. Compositions comprising a poly alpha-1,6-glucan ether compound can be useful in various applications.Type: ApplicationFiled: June 17, 2021Publication date: September 12, 2024Inventors: Brandon J. Burkhart, Michael D. Gagnon, Helen S. M. Lu, Weiming Qiu, Mark Robert Sivik
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Publication number: 20240301326Abstract: The present invention is directed to a stable cageless self-adhesive block composition and methods of use thereof, the composition containing (a) from about 10% to about 60% by weight of an inorganic sodium salt; (b) from about 15% to about 75% by weight of an anionic surfactant; (c) from about 0.1% to about 10% by weight of an adhesion promoter; (d) from about 0.5% to about 10% of a chelating agent, (e) an anti-oxidant, (f) a dye, and (g) a fragrance, wherein when applied to the walls of a sanitary appliance, said block composition stays adhered to the wall for at least a period of up to 7, 10, 14, 21, 28 or 60 days.Type: ApplicationFiled: July 22, 2022Publication date: September 12, 2024Inventors: Kapim Kumar BAGGA, Patricia Cristina Piedade GUEDES, Madhavi VADLAMUDI
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Publication number: 20240301327Abstract: Household and/or commercial cleaning articles including a textile layer, a foam or sponge layer, and/or an abrasive layer, which show Moraxella sp. inhibiting activity of a ratio of less than 0.025 (i.e. 40-fold) in a long-term polymer-matrix test. The result is the reduction of negative effects normally associated with Moraxella sp. in such articles.Type: ApplicationFiled: June 23, 2022Publication date: September 12, 2024Inventors: Julia Grote-Pastré, Olivier Bedue, Mauro Davanzo, Claudia Borgmeier, Paul Scholz, Jens-Peter Gersbach
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Publication number: 20240301328Abstract: The present invention relates to polypeptide variants having DNase activity and detergent compositions comprising the polypeptide variants, as well as methods for obtaining the variants, polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variants.Type: ApplicationFiled: March 9, 2022Publication date: September 12, 2024Applicant: Novozymes A/SInventors: Jesper Vind, Trine Holst Soerensen, Pengfei Tian, Jesper Henrik Rung, Anne Marie Schoenfeld
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Publication number: 20240301329Abstract: Anthracene-9,10-dione derivatives are capable of producing bleach-active species under irradiation of visible light, which lead to an increase of the bleaching power during the washing of textiles.Type: ApplicationFiled: November 10, 2022Publication date: September 12, 2024Inventors: Christian KROPF, Nadia LEDERMANN
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Publication number: 20240301330Abstract: This invention relates to a laundry care composition comprising a laundry care ingredient and a polymeric thiophene hueing agent.Type: ApplicationFiled: May 21, 2024Publication date: September 12, 2024Inventors: Wesley A. Freund, Richard Lawson, Sanjeev K. Dey, Nolan Peevy
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Publication number: 20240301331Abstract: Disclosed are an encapsulated composition comprising a plurality of core-shell microcapsules and a use of such an encapsulated composition for making a consumer product.Type: ApplicationFiled: February 16, 2022Publication date: September 12, 2024Inventors: Evelyne CACLIN, Aurelie FERRY, Anne-Sylvie SELEZNEFF, Sophie PERROT, Nicolas ANORGA
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Publication number: 20240301332Abstract: A beverage can include D ethyl 3-hydroxybutyrate, D 1,3-butanediol, D Beta hydroxybutyrate salts, D Beta hydroxybutyrate/D 1,3-butanediol monoester, D ethyl hydroxybutyrate, hydroxybutyrate, and/or D hydroxybutyric acid of at least 0.5 percent by volume. The percentage of D ethyl 3-hydroxybutyrate, D 1,3-butanediol, D Beta hydroxybutyrate salts, D Beta hydroxybutyrate/D 1,3-butanediol monoester, D ethyl hydroxybutyrate, hydroxybutyrate, and D hydroxybutyric acid can be between 5 and 19 percent, or can be higher than 19 percent. The beverage can be improved by the incorporation of flavor from hops and/or from other ingredients.Type: ApplicationFiled: February 8, 2024Publication date: September 12, 2024Inventors: Frank Borges LLOSA, Stephen ZARPAS
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Publication number: 20240301333Abstract: A brewing plant, comprising: a hot water storage device, including a high temperature portion and a low temperature portion, at least one high temperature water inlet, at least one high temperature water outlet, at least one low temperature water inlet, at least one low temperature water outlet; a mash container; a lauter tun or a mash filter flow connected with the mash container by a mash conduit; a wort kettle including a lauter wort inlet, a wort outlet, and an exhaust vapor condenser including a low temperature water connection and a high temperature water connection, wherein the lauter wort inlet is directly or indirectly connected through a lauter wort conduit with the lauter tun or the mash filter, wherein the low temperature water outlet of the hot water storage device is connected with the low temperature water connection of the exhaust vapor condenser.Type: ApplicationFiled: March 5, 2024Publication date: September 12, 2024Inventor: Stefan Pfister
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Publication number: 20240301334Abstract: A process and means for maturing large volumes of wine where the wine experiences controlled oxygenation through contact with oak and external air/oxygen sources. Wine from large holding tanks (500-10,000+ gallons) is passed through airtight baffle tanks containing cored oak baffles before being returned to the larger holding tank(s).Type: ApplicationFiled: February 1, 2023Publication date: September 12, 2024Inventor: Bryce A. Ecklein
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Publication number: 20240301335Abstract: A photobioreactor system includes a frame, a reflective wall coupled to the frame such that the reflective wall defines and circumferentially surrounds an interior chamber, and multiple light sources coupled to the reflective wall such that the multiple light sources circumferentially surround the interior chamber. The interior chamber is configured to receive a container that holds and supports growth of a desired organism.Type: ApplicationFiled: March 8, 2023Publication date: September 12, 2024Inventors: Benjamin Sidney Slotnick, Tarynn Daye Brewer
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Publication number: 20240301336Abstract: A protective carrier for a microcavity vessel is provided. The protective carrier comprises a substantially flat rigid plate comprising a top surface and a bottom surface. A flange disposed around at least a portion of a perimeter of the rigid plate, the flange extending from the top surface of the rigid plate. One or more ribs disposed on the bottom surface of the rigid plate. A protective microcavity vessel carrier system is provided that comprises a microcavity vessel comprising a microcavity substrate on a bottom surface; and a protective carrier. The microcavity vessel may be a microcavity flask, microcavity plate such as an open well reservoir plate, microcavity bioreactor, or a stacked 3D microcavity culture vessel.Type: ApplicationFiled: June 14, 2022Publication date: September 12, 2024Inventors: Thomas Albert Cloutier, William Joseph Lacey, Ana Maria del Pilar Pardo, Allison Jean Tanner
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Publication number: 20240301337Abstract: A biochip includes a first chip body configured to culture cells or biological tissues inside a first channel formed in the first chip body and including a first contact channel portion formed on one side communicating with the channel to be in close contact with a second contact channel portion of a second chip body; and a second chip body configured to culture heterogeneous cells or biological tissues, which are different from the cells or biological tissues cultured in the first chip body, in a second channel formed inside the second chip body and including the second chip body which is formed on a side facing the first chip body and forms the second contact channel portion in close contact with the first contact channel portion of the first chip body.Type: ApplicationFiled: March 6, 2024Publication date: September 12, 2024Applicant: DONGGUK UNIVERSITY WISE CAMPUS INDUSTRY-ACADEMY COOPERATION FOUNDATIONInventors: BONG SEOP KWAK, SUNG HAN LEE, JAE HUN LEE, YEONG WON KIM
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Publication number: 20240301338Abstract: A gel-encapsulated cell production apparatus according to an embodiment has a first droplet generator, a second droplet generator, and a gel-encapsulated cell generator. The first droplet generator generates a first droplet in which a processed cell is encapsulated. The second droplet generator generates a second droplet in which a gelator is encapsulated. The gel-encapsulated cell generator is connected to the first droplet generator and the second droplet generator via a channel, and the gel-encapsulated cell generator blends the first droplet and the second droplet and generates a gel-encapsulated cell, which is the cell encapsulated in a gel originating in the gelator.Type: ApplicationFiled: March 6, 2024Publication date: September 12, 2024Applicants: Canon Medical Systems Corporation, CANON KABUSHIKI KAISHAInventor: Kenta KAMINO
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Publication number: 20240301339Abstract: Provided is a culture material and a culture tool, which allow to culture, cells, etc. to form a spheroid. A culture material for culturing cells, a tissue, or an organ on a culture surface thereof, the culture material containing a 4-methyl-1-pentene polymer (X), having a water contact angle of the culture surface of more than 100° and 160° or less, and having an oxygen permeability at a temperature of 23° C. and humidity of 0% of 4500 to 90000 cm3/(m2×24 h×atm).Type: ApplicationFiled: December 6, 2021Publication date: September 12, 2024Applicant: MITSUI CHEMICALS, INC.Inventors: Katsuhiro ESASHIKA, Hiroshi MIYASAKO, Takashi KOZEKI, Koh AMANO, Yoshinobu SAIJO, Hisaaki YANAI
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Publication number: 20240301340Abstract: A scaffolding material for culturing a stem cell, which contains a synthetic resin, and has a nitrogen content of the synthetic resin of 0.1% by mass or more and 10% by mass or less. According to the scaffolding material for stem cell culture, the scaffolding material can have suitable hydrophilicity and strength, high fixation of stem cells after seeding, and highly efficient cell proliferation.Type: ApplicationFiled: May 17, 2024Publication date: September 12, 2024Applicant: SEKISUI CHEMICAL CO., LTD.Inventors: Satoshi HANEDA, Yuriko Manabe, Ryoma Ishii, Hiroki Iguchi, Hiroshi Yamauchi, Takahiro Omura
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Publication number: 20240301341Abstract: An apparatus for electroporation of biological cells is provided. The apparatus includes a sample container having an insulator chamber for holding the cells. The sample container has a first electrode and a second electrode to provide electrical connection for electroporation. The insulator chamber is configured to contain at least one cell monolayer. The apparatus also includes a pulse generator that can generate a predetermined pulse for electroporation of the cells.Type: ApplicationFiled: March 15, 2024Publication date: September 12, 2024Inventor: JIAN CHEN
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Publication number: 20240301342Abstract: It is an object to provide an observation method for improving culturing efficiency of cells and obtaining desired cells without cost. The present technology provides a cell treatment system including a cell culture unit capable of culturing a cell group, a measurement unit capable of measuring the cell group, and an estimation unit, in which the estimation unit estimates, on the basis of information regarding a cell before treatment of the cell group and at least one of information regarding a predetermined cell to reach after treatment of the cell group or a predetermined treatment condition for the cell group before treatment, a treatment condition under which the cell group is derivable to the information regarding the predetermined cell or information regarding the cell after treatment of the cell group derived by the predetermined treatment condition.Type: ApplicationFiled: December 28, 2021Publication date: September 12, 2024Applicant: Sony Group CorporationInventors: Masahiro Matsumoto, Kazuhiro Nakagawa
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Publication number: 20240301343Abstract: Methods and compositions are provided for preventing or reducing symptoms or disease associated with Xylella fastidiosa or Xanthomonas axonopodis in a plant. The invention provides novel bacteriophages virulent to Xylella fastidiosa or Xanthomonas axonopodis, including XfaMija and XfaMijo, and further provides methods for treating or preventing Pierce's Disease or Citrus Canker in plants.Type: ApplicationFiled: May 21, 2024Publication date: September 12, 2024Inventors: Carlos F. Gonzalez, Stephen J. Ahern, Mayukh Das, Ryland F. Young, III, Tushar Suvra Bhowmick
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Publication number: 20240301344Abstract: A method for preserving a fermentation broth of an engineered strain of D-psicose-3-epimerase includes: adding a lysozyme into a fermentation broth of an engineered strain of D-psicose-3-epimerase, stirring to make the OD600 of the fermentation broth less than or equal to 1 to obtain an enzyme solution; and adjusting the enzyme solution to be weakly alkaline with an alkali liquor, and storing the weakly alkaline enzyme solution at room temperature. According to the invention, the enzyme solution is obtained by adding the lysozyme after fermentation, and then adjusted to be weakly alkaline. The lysozyme can dissolve the engineered strain to release the enzyme, and can also inhibit the growth of microorganisms. The alkaline environment of the enzyme solution can further inhibit the growth of other microorganisms in the enzyme solution. Therefore, the storage life of the enzyme solution is prolonged while ensuring the enzyme activity.Type: ApplicationFiled: September 20, 2023Publication date: September 12, 2024Inventors: Zhewei ZHAO, Sanying WANG, Ziheng JIN, Yanjun WEN, Linzheng LI, Rongrong XIE, Tianyi PAN
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Publication number: 20240301345Abstract: Described in several exemplary embodiments are Bifidobacterium longum subspecies, microorganisms and formulations thereof. Described in several exemplary embodiments are formulations, such as synthetic formulations, that contain one or more of the Bifidobacterium longum subspecies microorganisms. Described in several embodiments herein is use of the Bifidobacterium longum subspecies microorganisms and formulations thereof, such as in an infant and/or young child.Type: ApplicationFiled: June 28, 2022Publication date: September 12, 2024Inventors: Ramnik Xavier, Hera Vlamakis, Tommi Vatanen, Olga Sakwinska, Léa Siegwald, Stéphane Duboux, Catherine Ngom-Bru
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Publication number: 20240301346Abstract: The invention relates to a three-dimensional cellular microcompartment or a three-dimensional cellular microcompartment assembly comprising at least one external hydrogel layer and inside said external layer at least one layer of cells and/or at least one cellular base layer, of which less than 20% of the total population of cells present in the microcompartment or in the microcompartment assembly are cells having at least one mutation. The invention also relates to a method for producing such a microcompartment or microcompartment assembly.Type: ApplicationFiled: May 11, 2022Publication date: September 12, 2024Inventors: Maxime FEYEUX, Philippe Joseph COHEN
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Publication number: 20240301347Abstract: One aspect of the present invention relates to a production method of a fragmented extracellular matrix component, the method including: a step of neutralizing a solution in which an extracellular matrix component is dissolved; a step of obtaining a mass containing the extracellular matrix component by removing the solvent through freeze-drying treatment after the neutralization step; a step of obtaining a liquid containing the fragmented extracellular matrix component by dispersing the mass in a solution containing a polar organic solvent and fragmenting the extracellular matrix component in the solution; and a step of removing a liquid component from the liquid containing the fragmented extracellular matrix component.Type: ApplicationFiled: June 29, 2022Publication date: September 12, 2024Applicants: TOPPAN INC., OSAKA UNIVERSITYInventors: Asuka YAMADA, Shiro KITANO, Michiya MATSUSAKI
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Publication number: 20240301348Abstract: The presently disclosed subject matter relates, in general, to the identification, isolation, and use of a population of stem cells isolated from umbilical cord blood, peripheral blood, and/or other sources that are referred to herein as Small Mobile Stem cells (short: SMS). More particularly, the presently disclosed subject matter relates to isolating said SMS stem cells and employing the same, optionally after in vitro manipulation, to treat tissue and/or organ damage in a subject in need thereof.Type: ApplicationFiled: March 15, 2024Publication date: September 12, 2024Inventor: Abdulkader Rahmo
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Publication number: 20240301349Abstract: Compositions and methods for improving embryo development, treating idiopathic male factor infertility, and enabling infertile/sub-fertile/sterile men to father their own genetic offspring are provided. Typically, the methods include administering into a male or female gamete or fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of an embryo resulting from fertilization of the female gamete by a male gamete. The compound can be administered into the gamete or embryo before, during, or after fertilization. The compound can be administered by an injection such as intracytoplasmic injection. The compound and the male gamete can be administered in combination by intracytoplasmic sperm injection. Methods of making male gametes, and methods of modifying the genome of a male gamete or embryo using an effective amount of a gene editing composition to correct a gene mutation or anomaly in the genome thereof are also provided.Type: ApplicationFiled: February 13, 2024Publication date: September 12, 2024Inventors: Charles A. Easley, IV, Anthony W.S. Chan
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Publication number: 20240301350Abstract: Embodiments of a method of modulating a potency level phenotype of a source population of cells include culturing the source cell population in a liquid medium within a cell culture incubator, the incubator is configured to independently regulate one or more variable parameters of gaseous conditions within the incubator, the more than one variable atmospheric parameters within the incubator being regulated independently of each other and independently of ambient external gaseous conditions. The method further includes regulating the one or more variable parameters of the gaseous condition within the incubator such that at least one of the one or more variable parameter differs from an ambient level of the respective variable parameter, and as a consequence of such difference from ambient conditions, the subset population is driven from a first potency level phenotype to a second potency level phenotype.Type: ApplicationFiled: October 6, 2023Publication date: September 12, 2024Inventors: James LIM, Bruce ADAMS, Zack PAPPALARDO, Brian FETH
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Publication number: 20240301351Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.Type: ApplicationFiled: May 13, 2024Publication date: September 12, 2024Inventors: Osnat Bohana-Kashtan, Lior Ann Rosenberg Belmaker, Ofer Wiser
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Publication number: 20240301352Abstract: The present invention provides a method for producing a chimeric antigen receptor T (CAR-T) cell, including a step of bead separating with a specific factor a T cell from a T cell source, wherein the specific factor is CD45RA+ or the like. The method enables production of CAR-T cells high antitumor property, and can produce highly functional CAR-T cells conveniently in a short time at a low cost.Type: ApplicationFiled: May 2, 2024Publication date: September 12, 2024Applicants: AGC INC., KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SHINSHU UNIVERSITYInventors: Megumi KISHIMOTO, Yuto SHIMIZU, Susumu KUBOTA, Shigeki YAGYU, Masaya SUEMATSU, Yozo NAKAZAWA, Miyuki TANAKA
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Publication number: 20240301353Abstract: The present invention relates to a method for improving proliferative property of a CMP or a myeloid progenitor cell, including a step of forcibly expressing a MYC family gene and BMI1 gene in any cell in the process of differentiation from a hematopoietic progenitor cell into a myeloid progenitor cell, wherein the myeloid progenitor cell is a progenitor cell of macrophage, dendritic cell, granulocyte, erythroblast, or erythrocyte.Type: ApplicationFiled: June 30, 2022Publication date: September 12, 2024Applicants: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, KYOTO UNIVERSITYInventors: Naoya TAKAYAMA, Koji ETO, Sou NAKAMURA, Sudip Kumar PAUL
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Publication number: 20240301354Abstract: A method of producing hematopoietic stem/progenitor cells (HS/PCs) and blood cells from adipose derived mesenchymal stem cells (Ad MSCs). The method comprises obtaining biological cells of a subject; expanding the biological cells; obtaining a pure Ad MSCs cell line from the expanded biological cells; converting the pure Ad MSCs cell line into HS/PCs in vitro; expanding the converted HS/PCs in vitro; and obtaining the expanded HS/PCs.Type: ApplicationFiled: March 11, 2024Publication date: September 12, 2024Inventors: WEI LI, Shaojin You, Michael Chengnan Lin, Annie You
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Publication number: 20240301355Abstract: Methods of inducing mammalian cardiac cell proliferation by ectopically introducing an LRRC10 protein in a mammalian cardiac cell to thereby induce proliferation of the cardiac cell. The methods can be employed to induce heart regeneration, for example, after cardiac injury.Type: ApplicationFiled: March 5, 2024Publication date: September 12, 2024Applicant: Wisconsin Alumni Research FoundationInventors: Ahmed Mahmoud, Timothy Kamp, Youngsook Lee
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Publication number: 20240301356Abstract: Mesenchymal stem cells which express TNF-? receptor Type I in an amount of at least 13 pg/106 cells. Such mesenchymal stem cells inhibit the proliferation of lymphocytes and may be employed, in particular, in the treatment of graft-versus-host disease.Type: ApplicationFiled: October 10, 2023Publication date: September 12, 2024Inventors: Alla DANILKOVITCH, Diane CARTER, Alicia Mildred TYRELL, Simon BUBNIC, Michelle MARCELINO, Rodney MONROY
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Publication number: 20240301357Abstract: The present invention is directed to a substrate material for the formation of cell spheroids/organoids and uses thereof. The invention further relates to methods of preparation of such a substrate material and related tools and uses thereof, methods using such a substrate material for the formation of cell spheroids and resulting spheroids and uses thereof.Type: ApplicationFiled: January 17, 2022Publication date: September 12, 2024Inventors: SANAE EL-HARANE, OLIVIER PREYNAT-SEAUVE, KARL-HEINZ KRAUSE, STÉPHANE DURUAL, ALI MODARRESSI, THOMAS BRASCHLER