Abstract: The present invention relates to nucleic acids coding for and capable of expressing a full-length rod-derived cone viability factor (RdCVF) and human IgK signal sequence and viral vectors containing these nucleic acids. The invention also relates to compositions and pharmaceutical preparations comprising these nucleic acids or vectors, methods of producing or secreting a full-length RdCVF and human IgK signal sequence, and methods of treatment.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SLC13A5 loss, misfunction and/or deficiency, including neurological disorders, diseases, and conditions such as epileptic encephalopathy. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for an SLC13A5 polypeptide.

Abstract: Lipid-based vesicles, typically herein called transfection competent vesicles (TCVs), configured to safely and efficiently deliver DNA, RNA, other nucleic acid and protein cargoes into target cells. The safety and efficiency are each, and both, achieved in part by eliminating organic solvents such as ethanol and detergents such as sodium dodecyl sulfate from the TCV loading processes (i.e., inserting a cargo into the TCV), TCV storage processes, and/or TCV delivery processes. The cargoes can also comprise nucleic acids complexed with a protein, such as a ribonucleoprotein (RNP). The systems, compositions, devices and methods, etc., herein, in some embodiments, can provide empty TCVs that can if desired be loaded at the bench without use of specialized equipment.

Abstract: Intraoperative ureter identification helps reduce the risk of ureteral injury. In this first-in-human phase 1 study, Pudexacianinium chloride was administered intravenously in healthy adult participants as a single bolus dose. This invention is related to a new amount of administration using Pudexacianinium or pharmaceutically acceptable salt thereof for intraoperative NIRF ureter visualization.

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

Abstract: Provided herein are radiopharmaceutical conjugate compositions and uses thereof. In one aspect, provided herein are conjugates that comprises a targeting ligand that covalently binds to a mutated or an overexpressed protein, optionally a linker, and a metal chelator. The conjugate can be configured to bind with a mutated or overexpressed protein inside a cell. Further provided herein are methods of treating cancer by administering the described conjugates and compositions.

Abstract: A diagnostic and therapeutic radiopharmaceutical includes or consisting of a trimeric amino acid structured peptide with a radiolabel. The radiolabel can be [99mTc] [Tc(H2O)3(CO)3]+ or alpha emitting 225Ac. The trimeric amino acid structured peptide can be formed around phosphorus. The trimeric amino acid can be one of a Glycine, Alanine and Arginine amino acids.

Abstract: A polypeptide targeting integrin ?6 and the use thereof. The polypeptide has a sequence motif of RWYD, and is stronger in affinity, wherein the equilibrium dissociation constant KD reaches the level of nM, and the affinity is greatly improved. The polypeptide has a strong affinity to integrin ?6, a strong specificity and no biological toxicity, is relatively stable in vivo and reasonable in distribution, and can be used as a targeting carrier. In addition, the polypeptide targeting integrin ?6 can be used as a molecular probe in the molecular imaging of various tumors with highly-expressed integrin ?6. Further provided is a dimer of the polypeptide, which has a more significant targeting effect and no biological toxicity. The polypeptide targeting integrin ?6 can be used in the molecular imaging of various tumors with highly-expressed integrin ?6, and has an important application value in the molecular imaging of tumors.

Abstract: The present disclosure relates to peptidic compounds of Formula A, A-II, A-III, B, or C, or salt or solvate thereof, compositions thereof, and methods of use thereof. The compounds of the present disclosure are useful for targeting CXCR4 for purposes such as imaging and/or therapeutics.

Abstract: The present invention is based on the finding that Netrin-(1) is retained in a stickier manner in the cell matrix at the cell periphery of the cancer cells, whereas Netrin-(1) is expressed in adults specifically in some tumors. It is also shown herein that Netrin-(1) is expressed very early during tumor formation. This makes Netrin-(1) an unexpected very specific target for imagery and/or targeted therapy. The present invention thus relates to compounds comprising an anti-Netrin-1 antibody, especially NP(137), a chelating moiety, optionally associated with a radioisotope, and their use either in imagery, diagnosis, especially companion diagnosis, or in targeted therapy. New diagnostic tests, which may be companion tests, and new cancer therapies, that may be combined to the companion test, are also proposed.

Abstract: The invention relates to anti-CAIX antibodies comprising a heavy chain constant region comprising one or more amino acid substitutions compared to a wild-type IgG, wherein the one or more amino acid substitutions reduce the affinity of the antibody for the neonatal Fc receptor (FcRn), thereby reducing the serum half-life of the modified antibody compared to a wild-type antibody of class IgG. The one or more amino acid modification having the effect of reducing FcRn binding is selected from positions His310, His433, His435, His436, Ile253. Antibodies of the present invention are particularly suited for use in radioimmunotherapy.

Abstract: An automated ultraviolet (UV) light hand sanitizing system. The automated hand sanitization system includes a housing for attachment to the wall or other suitable structure, a UV sterilization system on an angled underside of the housing, a motion sensing system to detect the user's hands and to begin the UV sterilization process, a timer system to track the time during the UV sterilization process, and a photovoltaic energy system to power the system.

Abstract: Ultraviolet light disinfection systems expose medical devices, surfaces, patients and healthcare clinicians to UV light having wavelengths consist with killing microorganisms. UV light systems may use logic to govern the operation of UV light sources so as to apply a disinfecting dose of the UV light. UV detectors measure UV light exposure. Enclosures contain medical devices and flood the medical devices with the UV light. Some enclosures accommodate a person. Some UV systems project UV light onto high-touch surfaces of a healthcare environment. Some systems may be deployed within a patient transport vehicle. Some UV systems may be incorporated into medical devices.

Abstract: A nasal swab kit for cleaning and sanitizing human nose nasal vestibules includes a pair of nasal swab devices, each of the devices having a body from which two spaced apart prongs extend, and each of the prongs having a free end to which a swab is attached. The swabs of a first of the devices are saturated with at least one cleaning ingredient selected from sterile water, glycerin, sodium chloride, sodium benzoate, PEG 60 hydrogenated castor oil, cocamidopropyl betaine and lavender oil. The swabs of a second of the devices are saturated with a sanitizing ingredient such as isopropyl alcohol or mupirocin. The kit includes a first packet inside which the first device is sealed and a second packet inside which the second device is sealed wherein the packets are conjoined at a perforated seam.

Abstract: With a fluid cleaning circulator having a hollow circular pipe in which a passage of a fluid is formed in a spiral shape, harmful microorganisms in the fluid are deactivated by ultraviolet light irradiation. Surface processing that reflects ultraviolet light is applied to an inner surface of the hollow circular pipe. A radiation prevention means that prevents radiation of an ultraviolet light from both ends of the hollow circular pipe to the outside is provided. An ultraviolet light LED element is provided on an inner wall of the hollow circular pipe only within a distance of approximately ½ of a flow passage length of the hollow circular pipe from a fluid inlet side end portion of a closed container of the hollow circular pipe.

Abstract: A delivery robot includes a cargo bin to carry cargo for delivery, and a door coupled to the cargo bin. The door to the cargo bin has an open state to allow access to an interior of the cargo bin, and a closed state to seal the interior of the cargo bin from an exterior environment. The delivery robot also includes a disinfecting light source operable to generate a disinfecting radiation to disinfect the interior of the cargo bin. The disinfecting light source is allowed to be activated when the door is in the closed state, and is prevented from being activated when the door is in the open state.

Abstract: A disinfecting system includes a housing. An ultraviolet light (UV) source is secured to the housing and configured to emit UV light for disinfection of a target. A processor is secured to the housing in communication with the UV light source. The processor is configured to activate the UV light source for a selected amount of time suitable for disinfection of the target.

Abstract: A method for preventing both active and passive early degeneration of prosthesis to be contacted with biological fluid is provided.

Abstract: A method for controlling microbial growth in a sugar processing system is disclosed. The method comprises adding a peroxy acid into water of an extraction system of the sugar processing system, wherein the extraction system extracts sugar from a sugar-containing plant material. The peroxy acid is added to the extraction system at one or more of the following addition points: water entering a diffuser of the extraction system, a mid-tower region of the extraction system, water entering the diffuser from a water supply, pressed pulp water from a pulp press of the extraction system, raw juice exiting a cossette mixer of the extraction system, juice recirculated from the diffuser to the cossette mixer, and a cossette slurry entering the cossette mixer. In one embodiment, the peroxy acid is peracetic acid.

Abstract: A system and method to open an antiseptic package includes a bacteria-proof packaging container having a first portion and a second portion that form an interior compartment. A medical implement is positioned within the interior compartment. The packaging container has at least one pocket to receive an end of a tool. The tool is manipulable to separate the first portion from the second portion. A portion of packaging container is removable from the antiseptic wipe to expose the medical implement while an unexposed end of the medical implement is graspable by a user through the packaging container.

Abstract: The system and methods described herein are directed to monitoring and tracking surgical instruments through sterilization processing. Imaging methods described are performed based on a variety of needs such as to monitor damage, wear, and biomass. Also described are how automation, vision augmentation, and data management systems can be incorporated into the system to facilitate monitoring and tracking. The system and methods described here will use specialized optical imaging methods together with automation and image analysis methods to perform inspection and tracking of surgical instruments faster, more accurately, and less expensively than using existing methods. The new imaging methods disclosed include ultraviolet fluorescence, polarization imaging, oblique illumination, and extensive light source in reflection. Further, the methods include using multiple imaging methods and imaging methods in combination with automation and imaging processing for assessing surgical instruments.

Abstract: An aroma generator including a cartridge holding unit equipped with a cartridge that holds a fragrance, and a control unit that automatically selects a type of the fragrance in the cartridge according to sensing information obtained from the outside. The sensing information may be external environment information and/or biological information. Furthermore, the aroma generator may further include an air blower that blows the fragrance in the cartridge, and the control unit may automatically change blowing intensity of the air blower according to the sensing information.

Abstract: An electro-ionic device configured for being worn on the face of a person is disclosed. The electro-ionic device includes at least two electrical conductors spaced apart from each other defining at least a portion of a respiratory pathway therebetween and a circuit configured to apply a first voltage between the two conductors during inspiration and a second voltage greater than the first voltage during expiration.

Abstract: A food waste disposal apparatus, according to one embodiment of the present disclosure, comprises: a chamber for accommodating food waste; and a deodorizing device for deodorizing gas inside the chamber. The deodorizing device may comprise: a photocatalyst filter arranged to be inclined; a light source unit for irradiating light having a frequency within a specific range to the photocatalyst filter; and an activated carbon filter in which activated carbon is accommodated so as to deodorize gas passing through the photocatalyst filter.

Abstract: This gas treatment device is provided with a cylindrical casing having a first opening and a second opening on the opposite side from the first opening, a specific plasma actuator disposed in the casing, and an ozone decomposition device, wherein the plasma actuator is disposed so that the direction in which the induced current is emitted is oriented towards the second opening, and produces, by means of the induced current, an airflow in the casing such that the airflow is directed from the first opening towards the second opening, the ozone decomposition device causes ozone included in the airflow to decompose, generating active oxygen in the airflow and causing the airflow to contain the active oxygen, and a gas flowing in from the first opening is treated by the active oxygen.

Abstract: The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.

Abstract: The present application relates to a method for preparing a pegylated collagen-like protein and the use thereof. The method includes reacting a collagen-like protein and a polyethylene glycol derivative at a molar ratio of the collagen-like protein to the polyethylene glycol derivative of 1 to 16:1 under the conditions of a pH of 6.0-8.0 and a temperature of 2-8° C. to prepare a pegylated collagen-like protein. In some embodiments, the reacting includes a reaction solvent of the collagen-like protein, and the polyethylene glycol derivative is water or a dilute hydrochloric acid solution. In some instances, the method may additionally include a purification step. The purification step may intercept substances with a molecular weight greater than or equal to 30,000 Da in the reaction product by filtration to obtain the PEGylated collagen-like protein.

Abstract: There has been required a novel and practicable multilayer structure that has enhanced structure stability and, therefore, is improved in the enlargement of device size, easiness in processing, etc. A structure according to the present invention that comprises a core layer comprising a pharmacological ingredient embedded in a chemically crosslinked alginic acid, a cationic polymer layer coating the core layer, and an anionic polymer layer coating the cationic polymer layer.

Abstract: The invention disclosed herein is directed to a porous wound healing foam composition that is made from an extracellular matrix of a mammal, method of making, and method of using.

Abstract: The present disclosure generally relates to nerve grafts (e.g., allografts), particularly to methods of preparing immunologically anonymized nerve segments and methods of preparing personalized nerve grafts. The present disclosure also provides methods of regenerating a nerve defect.

Abstract: An open type implantable cell delivery device for transplanting cells in a subject, comprising: a bottom film having a surface area with a plurality of pores; a top film having a surface area with a plurality of pores, positioned on top of the bottom film such that the top film substantially covers the bottom film to create an inner space; wherein the bottom film and the top film are formed from a biocompatible biomaterial, and wherein the bottom film comprises a plurality of microwells positioned to face the surface area of the top film with the open sides of said microwells, wherein the pore size of the bottom film and optionally the top film is such that it allows vascularization or vascular ingrowth in the device through the pores.

Abstract: A biological construct that conforms for fixation to a torn labrum, meniscus or tendon. The device includes a resilient triangularly or tent shaped construct that conforms to the anatomy to be treated. The construct includes a first a first surface, a second substrate surface and a third collagen surface.

Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.

Abstract: A medical device may be coated with a therapeutic composition that includes everolimus. Everolimus crystals may be coated with a mixture of excipients to form encapsulated everolimus crystals suspended in a coating composition. An illustrative coating composition may comprise a mixture of excipients including a bioresorbable or thermo-gelling polymer and a plasticizing agent and a therapeutic agent. The bioresorbable or thermo-gelling polymer may be selected from polycaprolactone (PCL) or poloxamer.

Abstract: Embodiments herein relate to biofouling resistant coatings for medical devices. In an embodiment, an anti-fouling coated medical device is included having a substrate and a coating disposed over the substrate. The coating can include a hydrogel, and a polyzwitterion. The polyzwitterion can include a bound portion and an unbound portion. In some embodiments the coating can further include a heparin compound. Other embodiments are also included herein.

Abstract: A medical device may be coated with a therapeutic composition that includes a direct oral anticoagulant. An illustrative drug coating composition may comprise an excipient including polylactic acid (PLA), poly(lactic-co-glycolic acid) (PLGA), or poly(vinylidene fluoride)-co-hexafluoropropylene (PVDF-HFP) and a direct oral anticoagulant (DOAC). The illustrative drug coating may be applied to an outer surface of a medical device.

Abstract: The present invention relates to a breast contacting element for a breast pump assembly and a method of forming the same. More specifically, there is provided a breast contacting element for a breast pump assembly, including an opening adapted to receive a nipple of a user's breast: a breast contacting surface extending from the opening and comprising a deformable portion for engaging the user's breast; and a channel configured for conveying a fluid pressure from the opening to the deformable portion such that the deformable portion deflects in response to the fluid pressure applied thereto. Specifically, the method includes forming a support element of a first material, the support element comprising an orifice and a channel extending from the orifice, and injecting a second material onto the support element so as to form a deformable portion across the orifice.

Abstract: A peritoneal dialysis system includes a water purifier; a disposable set including a water line in fluid communication with the water purifier, a drain line for draining from the disposable set, and a disposable container including at least one chamber, the disposable container including at least one concentrate in one of the at least one chamber, and the disposable container positioned and arranged to hold a dialysis fluid prepared by mixing water from the water purifier and the at least one concentrate; and a control unit in communication with at least one sensor, for detecting a first property of water from the water purifier and a second property of the dialysis fluid.

Abstract: A housing-free first dialyzer element has a hollow-fiber bundle, a fluid-permeable sheath wrapped around the periphery of the hollow-fiber bundle, cast elements at the axial ends of the hollow-fiber bundle, and end caps fastened to the cast elements for connection to an extracorporeal blood circulation. A second dialyzer element has a housing and can be closed, opened and reused. A dialyzer includes the housing-free first dialyzer element and the second dialyzer element that has a housing. A blood treatment device includes the second dialyzer element that has the housing, the second dialyzer element being rigidly fastened to a machine front. A method for reprocessing the second dialyzer element that has the housing can be used after blood treatment therapy.

Abstract: Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.

Abstract: The present disclosure relates to an automated peritoneal dialysis (APD) system using gravity to deliver fluid from one or more source dialysate bags to the patient as the destination. The present disclosure further relates to a drain container arrangement for receiving and storing spent dialysis effluent from a patient, wherein the drain containers include self-opening valves activated when the containers are arranged together, and the valves are self-sealing when the containers are disconnected from one another.

Abstract: A hemofilter system. In one embodiment, the hemofilter system includes a container having a first surface, a second surface, and one or more wall surfaces, the first surface, the second surface and the one or more wall surfaces defining a volume; an input port in fluid communication with the first surface; an output port in fluid communication with the second surface; a filter bed comprising a plurality of planar magnetic meshes stacked in close juxtaposition and positioned within the container volume and coplanar with the first and second surfaces; a first magnet positioned on a first surface of the container; a second magnet positioned on the second surface of the container; a first input conduit in fluid communication with the input port; and a first output conduit in fluid communication with the output port. In another embodiment, the hemofilter system includes a pump in the input conduit.

Abstract: An apparatus includes a blood-flow-management assembly shaped to define a cylindrical aperture. The blood-flow-management assembly includes a blood collector having drainage holes configured to direct blood to a guide surface positioned below the blood collector. The guide surface may further include ribs that manage blood flow along the guide surface.

Abstract: The present disclosure provides in part improved apparatuses, systems, and methods for providing therapy to a wound. A system can include a first power source configured to power an electronic component and a second power source configured to power the electronic component in place of the first power source. Responsive to a first condition, the second power source can power the electronic component in place of the first power source. In some cases, the system can include a pressure source that is configured to provide negative pressure to a wound dressing positioned over a wound. The wound dressing can support the first power source or the second power source.

Abstract: Systems are described, including a system that includes an insertion device with a shaft and a distribution adapter with a housing and a piston. The shaft includes irrigation and aspiration channels providing a fluid circulation through a target area of a body within which the shaft is inserted. The housing includes first and second pairs of diametrically opposed ports. A first port of the first pair is connected to an irrigation port and a second port of the first pair is connected to the irrigation channel. A first port of the second pair is connected to an aspiration port coupled to a negative pressure source and a second port of the second pair is connected to the aspiration channel. The piston is slidably received within a cavity of the housing to be movable between default and reverse configurations.

Abstract: Embodiments disclosed herein are directed to the treatment of wounds using negative pressure. Some embodiments disclosed herein provide for a hydrophilic drainage layer, which may be suitable for use in abdominal wound sites, and which may be sized in a dimensionally-independent manner. Additional embodiments provide for an organ protection layer, as well as a system for the treatment of abdominal wounds.

Abstract: Surgical drains may include a tube, a drainage component, and an positioning mechanism positioned between them. The positioning mechanism may include a shaft configured to encircle a junction between the tube and the drainage component and a plurality of extensions that extend from the shaft. The drainage component may have a plurality of holes sized and configured to allow fluid, solids, and/or gas to pass therethrough, enter a lumen of the drainage component, and be communicated to a lumen of the tube for evacuation from a hollow organ and/or tissue in which the surgical drain is placed. On some occasions, the surgical drain may be placed within a uterine cavity via a hysterotomy following pelvic surgery and may be used to evacuate blood and other fluids from the uterine cavity and/or contract the uterus following caesarian delivery of a fetus.

Abstract: A system for subatmospheric pressure therapy in connection with healing a wound is provided. The system includes a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source. The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent conduit in fluid communication with the collection canister and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit.

Abstract: Articles such as dual-barrel injectors are generally described. Associated systems and methods are also described. In some embodiments, the articles are useful for injecting viscous fluids, such as concentrated drug formulations. In certain embodiments, the article comprises a first conduit (e.g., for transporting a viscous fluid) and a second conduit (e.g., for transporting a lubricating fluid). In some embodiments, the fluid from the second conduit (e.g., a lubricating fluid) lubricates the flow of the fluid from the first conduit (e.g., a viscous drug) by surrounding the fluid from the first conduit, and the lower viscosity of the fluid from the second conduit allows the fluid from the first conduit to flow more easily through the system.

Abstract: Techniques are provided for identifying an infusion cassette of an infusion pump that are simple to implement yet sophisticated enough to convey pump parameter data to the infusion pump when the infusion cassette is inserted into a receptacle of the infusion pump. The infusion pump includes a pump that acts on tubing to pump fluid through the tubing and a receptacle configured to receive an infusion cassette. The tubing passes through the infusion cassette and engages the pump when the infusion cassette is fully inserted. A detection system identifies the type of infusion cassette and sets and/or limits infusion pump parameters based on the detected type of infusion cassette. The detection system includes sensors within the infusion pump that detect the presence/absence of holes or other types of markings (e.g., colored regions or textured areas) on the infusion cassette in order to determine the type of infusion cassette and associated pumping parameters.