Abstract: A portable, patient operated respiratory device that incorporates both an airway clearance device and a phlegm elimination system in a single unit.

Abstract: A patient interface comprising a seal-forming structure with one or more adhesive surfaces is provided. The seal-forming structure is configured to form a seal with a region of the patient's face surrounding an entrance to the patient's airways. The patient interface may further comprise a plenum chamber pressurisable to a therapeutic pressure of at least 6 cmH2O above ambient air pressure. A flow of breathable gas at the therapeutic pressure is provided through an air circuit. The seal-forming structure may be configured to adhere to inferiorly facing surfaces of the patient's nose, e.g. the alar rim region.

Abstract: A face mask that can be used for the ventilation of patients such as in bag-valve-mask resuscitator systems is provided. The face mask can be used to form a tight seal with the patient's mouth and nose, while also creating an open airway. The face mask includes a jaw (chin)-lifting member that can be used to position the patient's head in a tilted position. The invention also encompasses bag-valve mask resuscitator systems and methods for using bag-valve mask resuscitators in the ventilation of patients. In one embodiment, the bag-valve mask resuscitator is placed so that the bag is positioned over the midline of the face of the patient.

Abstract: A respiratory mask system is provided comprising a respiratory mask and a head engaging portion, wherein the head engaging portion is configured to couple to the respiratory mask to engage a wearer's head via a disengageable mechanism. The disengageable mechanism may comprise a linking member attached to the head engaging portion, a disengagement member attached to the respiratory mask and configured to receive the linking member, wherein the disengagement member is configured to be moveable between a first position and a second position, a control configured to allow a wearer of the mask to move the disengagement member towards the first position and one or more surfaces defined by the disengagement member and configured to exert a frictional force on the linking member.

Abstract: A nasal cushion for a respiratory interface has a central portion and left and right wings that extend to respective left and right lateral ends from the central portion. The cushion has an inner cushion wall to contact a patient's face and a non-face contacting outer cushion wall. A connecting wall connects the inner cushion wall and outer cushion wall. The cushion also has a bellows extending in length along the connecting wall and in depth into the cushion at each of the left and right wings of the cushion. Each of the bellows are expandable to increase a spacing between the inner cushion wall and outer cushion wall.

Abstract: The present disclosure relates generally to breathing apparatuses where inhaled air and exhaled air are separated into different channels to permit a user to inhale fresh air. These devices can optionally filter inhaled air and exhaled air. These devices may include valves to help guide inhaled air and exhaled air to desired locations.

Abstract: Systems and methods may include a gas source, a gas delivery circuit, and a nasal interface allowing breathing ambient air through the nasal interface. A gas flow path through the nasal interface may have a distal gas flow path opening. A nozzle may be associated with a proximal end of the nasal interface a distance from the distal end gas flow path opening. At least a portion of an entrainment port may be between the nozzle and the distal end gas flow opening. The nozzle may deliver gas into the nasal interface to create a negative pressure area in the gas flow path at the entrainment port. The nasal interface and the nozzle may create a positive pressure area between the entrainment port and the distal end gas flow path opening. Gas from the gas delivery source and air entrained through the entrainment port may increase airway pressure or lung pressure or provide ventilatory support.

Abstract: A mask assembly includes a mask interface and a headgear assembly. The mask interface includes a housing and a seal that seals around a user's nose and/or mouth in use. The headgear assembly secures the mask interface to the user's face in use. The headgear assembly can include a top strap, a rear section, and side arms. The top strap can be manually adjustable. The rear section can be temporarily expanded to allow for donning and/or doffing of the mask assembly. The side arms can be automatically adjustable.

Abstract: A connector piece for connecting breathing tubes of an anaesthetic breathing circuit to an endotracheal tube for use with a mammal. The connector piece having a gallery from which radiate first, second and third tube connectors. The first tube connector disposed between the second and third tube connectors. The first, second and third tube connectors having respective first, second and third longitudinal axes. The first and second tube connectors for connection to respective first and second the breathing tubes. The third tube connector for connection to the endotracheal tube. The third tube connector disposed at an obtuse angle to the first tube connector with the third longitudinal axis intersecting the first longitudinal axis within the gallery, and the second tube connector disposed at an acute angle to the first tube connector, with the second longitudinal axis intersecting said first longitudinal axis outside of the connector piece.

Abstract: A coupler includes: a first connecting portion, an accommodating portion and a second connecting portion; the first connecting portion is operatively connected to a gas-providing circuit; the second connecting portion is operatively connected to a gas-delivering circuit, where the gas-providing circuit, the coupler and the gas-delivering circuit form a pathway for providing gas to a user at a patient side of the coupler; the accommodating portion is provided with at least one sensing apparatus or a heating apparatus, where the at least one sensing apparatus is configured to measure a first parameter of the gas, and the heating apparatus is configured to heat the gas passing through the coupler.

Abstract: A conduit connector assembly is provided for a respiratory therapy apparatus and configured to connect a patient interface to a gas delivery conduit. The assembly comprises: a conduit comprising a first flow port configured to be connected to the patient interface, and a second flow port configured to be connected to the gas delivery conduit, and a supplementary flow port; and a first valve port configured to be closed or opened by a valve flap. The conduit and the valve flap selectively provide an inspiratory flow path from the second flow port of the conduit to the first flow port of the conduit; and an expiratory flow path from the first flow port of the conduit to the supplementary flow port via the first valve port. A supplementary gas flow path is provided between the first and/or second flow ports and the supplementary flow port via a supplementary valve port.

Abstract: A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.

Abstract: A humidification system for delivering humidified gases to a user can include a heater base, humidification chamber having an inlet, outlet, and associated fluid conduit, and breathing circuit including a supply conduit, inspiratory conduit, and optional expiratory conduit. The humidification system can include various features to help make set-up less difficult and time-consuming. For example, the supply conduit, inspiratory conduit, and optional expiratory conduit can be coupled into a one-piece circuit to aid set-up. Various components can be color-coded and can have corresponding structures to indicate which components should be connected to one another during set-up. Such features can also help make the set-up process more intuitive for an operator, which can reduce the need for specialized training and reduce the number of potential errors.

Abstract: An anaesthesia non-rebreathing circuit for a smaller-sized mammal, the anaesthesia non-rebreathing circuit is a Lack circuit having an adjustable pressure limited valve disposed at the exhalation port located at the fresh gas inlet end of the circuit. The fresh gas delivered by a first conduit from a vaporiser to a patient adaptor. The circuit having a heating arrangement for heating gas within said first conduit.

Abstract: A ventilation arrangement and a ventilation process provide ventilation for a patient. A first segment of a fluid guiding unit connects a fluid delivery unit to a valve (10). A second segment connects the valve (10) to a coupling unit on the patient side. A position of a valve body (19) of the valve (10) relative to a valve body seat (18) depends on an inlet pressure (P2) and on a control pressure (P1) and influences the volume flow (Vol?) through the second segment. An actuator (15) changes the control pressure (P1). A control signal (Sigcon) for the actuator (15) is generated with the objective of ensuring that the pressure or volume flow (Vol?) in the second segment assumes a predetermined value. A compensation signal (Sigcomp) for the actuator (15) is generated with the objective of preventing the valve body (19) from vibrating relative to the valve body seat (18).

Abstract: Technologies are provided for implementing an interpretation bias modification (IBM) therapy using a mobile device. Some embodiments include a computing device that can initiate a session for interpretation bias modification (IBM) therapy, and can present, as part of the session, a statement describing an ambiguous anger-provoking situation. The computing device also can present, as part of the session, a second statement that comprises a non-threatening interpretation of such situation. That interpretation can be presented in natural language and missing at least one character. The computing device also can receive input defining one or more characters, and can determine that the one or more characters correspond to the at least one character missing in that interpretation.

Abstract: In one aspect, a computer-implemented method of adapting a sensory datastream is provided. The method includes obtaining a raw sensory datastream from a source, wherein the raw sensory datastream comprises input for a sensory actuator of a user device. The method includes obtaining state information, wherein the state information comprises information indicating a first state of a user. The method includes predicting, using a machine learning model, a desired second state of the user based on the obtained state information. The method includes determining an action to adapt the raw sensory datastream based on the desired second state of the user. The method includes adapting the raw sensory datastream in accordance with the determined action and the first state of the user to create a processed sensory datastream. The method includes providing the processed sensory datastream to the sensory actuator of the user device.

Abstract: A processing system includes methods to promote sleep. The system may include a monitor such as a non-contact motion sensor from which sleep information may be determined. User sleep information, such as sleep stages, hypnograms, sleep scores, mind recharge scores and body scores, may be recorded, evaluated and/or displayed for a user. The system may further monitor ambient and/or environmental conditions corresponding to sleep sessions. Sleep advice may be generated based on the sleep information, user queries and/or environmental conditions from one or more sleep sessions. Communicated sleep advice may include content to promote good sleep habits and/or detect risky sleep conditions. In some versions of the system, any one or more of a bedside unit 3000 sensor module, a smart processing device, such as a smart phone or smart device 3002, and network servers may be implemented to perform the methodologies of the system.

Abstract: The present invention relates to an auditory device that combines bone-conducting earbuds with integrated electroencephalography (EEG) sensors. The device utilizes bone conduction technology to transmit sound through the skull to the inner ear, allowing for clear audio perception without obstructing the ear canal. Incorporated EEG sensors are configured with spring-loaded contacts that maintain consistent skin contact to monitor brain wave activity effectively. This dual-functionality enables users to listen to audio and simultaneously track cognitive states, making the device particularly useful for applications in cognitive load monitoring and adaptive audio feedback based on the user's mental state. This innovation extends the functionality of conventional earbuds with bone-conduction mechanisms by integrating EEG technology to enhance biosensing, health monitoring, and tailored cognitive-processing feedback.

Abstract: An intravascular blood pump for percutaneous insertion comprises a catheter (10) and a pumping device (1) attached to the catheter (10). The catheter (10) extends along a longitudinal axis and has a distal end (11) and a proximal end (12) opposite the distal end (11). The catheter (10) comprises an elongate stiffening structure (15) extending continuously longitudinally along the length of the catheter (10) between the proximal end (11) and the distal end (12) of the catheter (10). The stiffening structure (15) may comprise a shape-memory material, such as Nitinol. It may be in the form of a wire that extends loosely through the lumen of the catheter and helps to avoid or significantly reduce kinks in the catheter.

Abstract: A vascular access system includes a catheter assembly having a catheter and a near patient access port. A sensor probe delivery device is coupled to the near patient access port, with the delivery device including a sensing probe assembly having a probe member including one or more sensors and an electrical connector positioned proximally from the probe member. A housing of the delivery device movably receives the sensing probe assembly and includes a detachable portion separable from a remainder of the housing. A lock couples the housing to the near patient access port, and an advancement member may move relative to the housing to move the sensing probe assembly between a first position and a second position, with a distal end of the probe member disposed into or out past the catheter when in the second position to enable measuring of one or more blood-related parameters.

Abstract: An apparatus for guiding an elongated flexible instrument comprises a variable-length support assembly. The variable-length support assembly includes a first end, a second end, a plurality of support member pairs, and a plurality of eyelets configured to receive the elongated flexible instrument. Each support member pair comprises a first support member linked to a second support member, and each of the plurality of eyelets is movably coupled to at least one of the plurality of support member pairs along a longitudinal central axis between the first end and the second end. The variable-length support assembly is configured to selectively transition from a compressed configuration to an expanded configuration along the longitudinal central axis, and the plurality of eyelets are adapted to support the elongated flexible instrument as the elongated flexible instrument is advanced along the longitudinal central axis.

Abstract: Disclosed is an intraluminal catheter that includes a flexible elongate shaft configured to be positioned within a body lumen of a patient, and an intraluminal sensor disposed at the distal portion of the shaft that is configured to sense a characteristic within the body lumen. The shaft further comprises a plurality of wires disposed around a lumen, wherein the wires are helically twisted. The wires can be helically twisted in a single direction to form a cylindrical shape. This helical structure is configured to stiffen the flexible elongate shaft for movement into an obstruction within the body lumen without kinking.

Abstract: Disclosed is an interlock assembly for a catheter with features that provide an improved connection between a marker band and microfabricated tube. The microfabricated tube features radial apertures that reduce the outer diameter of the distal region of the catheter, allow the catheter to fit into smaller size vessels, and permit an outer laminate to flow into the apertures while still having a large structural shape to interlock with the marker band.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: Example catheter control systems and methods are described. In one implementation, an apparatus includes a housing that includes a first lumen configured to receive a catheter, a second lumen configured to receive fluid, and a third lumen configured to allow the catheter and the fluid to pass through the third lumen simultaneously. A catheter controller is associated with the housing and controls movement of the catheter through the housing.

Abstract: A guide wire includes a core wire having a first magnetized region magnetized on the distal end side of the core wire, and a maximum value of the outer diameter of the first magnetized region is larger than an outer diameter of the distal end portion in an area located to the proximal end side of the first magnetized region.

Abstract: A catheter insertion device that allows for single-handed insertion of the catheter within the vasculature of the patient is disclosed. The catheter insertion device includes a handle, a needle cannula partially within the handle, a guidewire partially within the handle and the needle cannula, and an actuator connected to the handle and the guidewire. The guidewire is movable relative to the handle in a distal direction away from the handle, and in a proximal direction towards the handle. A catheter assembly is removably coupled to the handle and is configured to slide on the needle cannula. A catheter hub may be connected to a proximal end of the catheter, and a catheter advancer base may be releasably connected to the catheter hub. The catheter insertion device may also include a needle support pivotally connected to the handle for supporting the needle cannula on a cantilever portion thereof.

Abstract: Provided herein is a catheter system including a catheter and associated catheter device, with the catheter device including a side port in fluid communication with the catheter. Extension tubing is provided that is in fluid communication with the side port, the extension tubing having a proximal access port. A stabilization anchor platform is spaced from the catheter device and integrated with a component or tubing of the catheter system, with the stabilization anchor platform configured to retain the component or tubing in place relative to a skin surface of a patient. The stabilization anchor platform may be integrated with a near-patient access port, intermediate tubing, extension tubing, proximal access port, or force controlled release connector of the catheter system.

Abstract: Dressing systems and methods of using the same are included herein. An exemplary dressing system can comprise a top layer comprising a first top layer element and a second top layer element, the first top layer element comprising a central area of a transparent window film having a first adhesive surrounded by the second top layer element comprising a border area of a polyurethane fabric having the first adhesive or a second adhesive, a bottom layer comprising a first bottom layer element and a second bottom layer element, the first bottom layer element comprising a second central area of the transparent window film having the first adhesive surrounded by the second bottom layer element comprising a border area of the polyurethane fabric having the first adhesive or the second adhesive, and a carrier configured to engage the top layer and the bottom layer.

Abstract: A lymphatic puncture device with a stabilization mechanism preventing overperforation of the lymph node is described. In some embodiments, the device comprises flared tines and a retractable sleeve and a needle extending distal beyond the flared tines. Upon retraction of the sleeve and exposure of the flared tines, the needle can be inserted into the lymph node without risk of overperforation.

Abstract: The present disclosure relates to guidewire devices having shapeable tips and increased flexibility. In one embodiment, a guidewire device includes a core having a proximal section and a distal section. The distal section includes a terminal section proximally adjacent to a distal end of the core, wherein the length of the terminal section is greater than the distance between a proximal end and a distal end of the terminal section. The terminal section may be curved or bent to form creases along distinct lines.

Abstract: In one embodiment, the present application discloses, in part, a balloon catheter assembly comprising: a) a balloon catheter comprising a proximal end, a distal end; and b) a connecting line comprising a proximal end and a distal end, wherein the proximal end comprises a first terminal magnetic connector for forming a water tight connection with the magnetic click connector on the port panel.

Abstract: A balloon catheter includes an inner layer tube, an outer layer, a balloon, and an adhesive layer. The outer layer covers an outer peripheral surface of the inner layer tube. The balloon covers an outer peripheral surface of the outer layer. An inner space of the balloon and an inner cavity of the inner layer tube are in communication with each other. The adhesive layer is placed between the inner layer tube and the outer layer.

Abstract: Disclosed is a valve assembly operable to selectively control a flow or passage of a fluid. The valve assembly may be applied to any appropriate mechanism such as a hydrocephalus shunt, fluid draining sewage system, or tank holding system. The valve assembly disclosed may include a selected profile for various applications.

Abstract: An introducer for inserting a medical access device into an opening of a patient, the medical access device including a sleeve portion including a proximal end and a distal end; a proximal ring coupled to a proximal end of the sleeve portion; a collapsible distal anchor member coupled to the distal end of the sleeve portion; wherein the sleeve portion, proximal ring, and distal anchor member form a lumen for access into the opening of the patient, the introducer including: a shaft having a proximal end and a distal end; and an introducer head at the distal end of the shaft, the introducer head including a plurality of distally-extending prongs.

Abstract: The present disclosure provides for systems, methods, and devices for facilitating conception. According to the present disclosure, a conception facilitating device may comprise at least one frame and at least one base. In some embodiments, the at least one frame may be configured to at least partially surround the at least one base. In some aspects, the conception facilitating device may be configured to be insertable into a vaginal canal. The conception facilitating device may be comfortably inserted into a vaginal canal for a period of time, which may increase the possibility of conception.

Abstract: A solution blow spin device includes a syringe pump assembly, an airbrush adapter, and a handle base. The syringe pump assembly, airbrush adapter, and handle base are reversibly coupled to one another and configured to work in tandem to address wound dressing using a polymer solution and autologous skin cell suspension co-spray. The airbrush adapter includes multiple nozzles for deposition of multiple solutions sequentially or simultaneously in order to improve would dressing efficacy. The syringe pump assembly includes multiple syringes holding the multiple solutions, and the syringes can be emptied by individually addressable lead screws configured to translate blocks to depress syringe plungers when the lead screws are rotated via corresponding actuators.

Abstract: A method for treating active acne or any other inflammatory skin condition, such as, but not limited to, rosacea, psoriasis, and the like is disclosed comprising using a microneedling device capable of achieving certain specific depths which are controllable by the user and a medical grade anti-inflammatory antibacterial antioxidant oil which is applied to the treatment area both before and after the microneedling. In a preferred embodiment, the oil is a medical grade CBD tincture with organic hempseed oil. The treatment is repeated until satisfactory resolution of the acne or any other inflammatory skin condition that is being treated has been achieved.

Abstract: There is provided a microneedle apparatus 100 for engaging a surface, the apparatus 100 comprising a housing 104 comprising a socket 106; and a microneedle device 102 moveable within the socket 106, the microneedle device 102 comprising a substantially spherical substrate 102a and a plurality of microneedles 102b projecting from the substrate 102a, the microneedle device 102 being configured to move within the socket 106 and against the surface with 3-dimensional movements such that, in use, the plurality of microneedles 102b engage the surface. There is also provided a method of engaging a surface, such as by using the microneedle apparatus 100.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Abstract: The present invention relates to a microneedle array for use in the intradermal application of active substances, the array comprising a plurality of microneedles on a support which are formed of a formulation that contains a biodegradable polymer, an active substance and an antiseptic.

Abstract: A method of fabricating a microneedle is disclosed, including: applying a force to a conductive wire to create a friction weld between the wire and a substrate; extruding the wire and interrupting the wire bonding process; and applying a wire weakening process at a desired microneedle length to cause the wire to break at the desired microneedle length. A microneedle array includes a substrate and a plurality of solid microneedles provided on the substrate. Adjacent microneedles may have different heights and different diameters. The substrate defines a plurality of microfluidic channels each having a channel outlet. the channel outlets provided adjacent the bases of the plurality of solid microneedles to enable drug delivery. The method and array overcome issues with needle stick injuries and needle phobia, and can be used without direct medical supervision, thus reducing healthcare expenditure.

Abstract: An application apparatus (1) for at least one implant comprises a cannula (3) via which the implant is supplied to a target implantation location. An applicator housing body (32) comprises a depot volume for storing the implant. A plunger (11) of a plunger device (10) can be displaced between an initial position and an implantation position. The plunger device (10) comprises a plunger actuation body (12) to which the plunger (11) is rigidly connected. The applicator housing body (32) is intended here for guiding a displacement movement of the plunger device (10). An initial-position locking device is intended to releasably lock the applicator housing body (32) with the plunger device (10) in the initial position thereof. The initial-position locking device can be switched between a locking position and a functional position in which the plunger device (10) can be displaced in order to displace the plunger (11) relative to the applicator housing body (32).

Abstract: An access port member includes: a body 8 internally including a flow path 8b for circulating blood and having an opening 8c communicating with the flow path 8b; a valve 9 made of an elastic member covering the opening 8c and attached to an attachment part 8d of the body 8, the valve 9 including a slit 9a that makes a transition from a closed state to an open state when pressed by a tip 11a of a syringe 11 capable of collecting blood or injecting a drug; a cap part 10 welded and fixed to the body 8 with the valve 9 interposed therebetween and the slit 9a facing outward; and a depression 8e formed at a position between a welding part Y1 and the attachment part 8d of the body 8.

Abstract: A needleless connector including a valve stem operatively secured with a valve body by a vale cap, the valve body including a passageway, the valve stem including a lumen, such that being accessed by an access device, fluid flows through the lumen and fluid passageway and a tubular segment composed of copper positioned with the fluid flow.

Abstract: An intravascular blood pump may be provided, that may include a catheter a miniaturized solid state pump section coupled to a distal end of the catheter. The pump section may include an electric motor comprising a stator and a rotor operably coupled to the stator, a rigid drive shaft disposed within the pump section where the drive shaft is operably coupled to the rotor, and an impeller housing in which an expandable impeller is housed, the expandable impeller being coupled to the drive shaft.

Abstract: A docking unit for use in a modular mammalian body implantable device. The docketing unit comprising an elongated body. The body has: a longitudinal axis, at least one receiving surface extending parallel to the longitudinal axis, a distal end and a proximal end, and at least one proximal guide hole. Each receiving surface has at least one proximal guide hole associated therewith. The docking unit is dimensioned and shaped to be deliverable to an implantation site within a conduit of a conduit system of the mammalian body via a catheter.

Abstract: A sheath for receiving a medical device includes a hub and a body portion. The body portion is configured to be disposed in a patient. An access conduit is coupled to the hub. A stopcock is coupled to the access conduit opposite the hub. The stopcock includes a first leg coupled to the access conduit, a second leg having a male luer connector, and a third leg having a female luer connector.

Abstract: Methods and apparatus for determining a position of a heart pump in a heart of a patient are described. The method includes receiving a pressure signal from at least one pressure sensor arranged on the heart pump, generating a histogram of values observed within a time window associated with the pressure signal, and determining the position of the heart pump based, at least in part, on a morphology of the histogram.