Abstract: An optical test system and corresponding method disclosed herein provides highly accurate test data for both sides of a lens simultaneously and efficiently to analyze the surface topography and/or geometric parameters of a lens or lens system. More particularly, the optical test system and corresponding method moves the lens in test plane to align a plurality of points of a test pattern on a lens surface with a vertical axis while probes aligned with the vertical axis and on opposing sides of the lens simultaneously collect wavelength-specific data for both lens surfaces. The optical test system uses the collected wavelength-specific data to produce a surface topography and/or the associated lens geometric parameters for each lens surface.

Abstract: A method for correcting a time-dependent measurement signal generated by means of an electric motor coupled on the output side to a transmission with regard to the influence of a variable output load and a variable rotational speed includes: tapping a time-varying measurement signal which is dependent on a torque of the motor transmission unit; generation of a useful signal, which is free of any DC component, from the measurement signal; interval-by-interval determination of RMS values from the measurement signal; generation of a load-corrected useful signal by an interval-by-interval division of the useful signal, which is free of any DC component, by the interval-specific RMS values; time-resolved determination of the rotational frequency of the motor from the measurement signal; scaling the load-corrected useful signal to the mean rotational frequency to generate a corrected measurement signal, and, use of the corrected measurement signal for fault detection of the motor transmission unit.

Abstract: Conformance testing of a rebuilt motor includes disposing a motor under test in a motor test stand, coupling a plurality of sensors to the motor under test including a first vibrational sensor to the motor under test; a first temperature sensor to the motor under test; a first rotational speed sensor to the motor under test. A set of test parameters are received comprising parameters for a conformance test, the test parameters including a vibrational sensor parameter, a temperature sensor parameter, and a rotational speed parameter. A motor under test is placed in an on-state and a processing device receives sensor data simultaneously from the sensors, determines that the rotational speed satisfies the rotational speed parameter, and stores time sampled sensor data received from the plurality of sensors relative to a time zero corresponding to a time when the rotational speed satisfies the rotational speed.

Abstract: A method for authorizing an update of a switching threshold of a magnetic-field sensor for an internal combustion engine of a motor vehicle, in order to ensure an immunity of the sensor to external magnetic disturbances. The sensor detects magnetic-field variations induced by a passage of the teeth of a target in proximity to the sensor, by generating a magnetic signal exhibiting oscillations, certain of which may be due to magnetic disturbances and be not to be taken into account in the update by the sensor of the switching threshold, which is recomputed depending on a detected amplitude of at least two consecutive oscillations of the magnetic field. An update of the switching threshold is suspended when an oscillation frequency computed between the at least two consecutive oscillations is higher than a maximum oscillation frequency computed from a predetermined speed of rotation of the engine and from the number of teeth on the target.

Abstract: The present teachings generally provide for an overrunable test vehicle for dynamic vehicle testing of advanced driver assistant systems along a driving plane. The overrunable test vehicle comprising a chassis with a first end and a second end and including a mounting area configured to receive a soft target, and defining an axis of rotation transverse to the driving plane between the first end and the second end, four drive mechanisms coupled with the chassis, each drive mechanism having an electric motor with a drive wheel, and a control system coupled with the electric motors, and configured to control speed and torque of each of the electric motors, forming a torque vector that rotates the overrunable test vehicle about the axis of rotation to a target rotation angle. The axis of rotation is a location between the two drive mechanisms that the chassis turns about when the torque vector is applied to the chassis of the overrunable test vehicle.

Abstract: A control method of a vehicle (1) according to the present disclosure is a control method for controlling a vehicle (1) that has tires (6) mounted thereon and drives autonomously on a course (200) that includes a banked section (230). The control method includes an acquisition step of acquiring a detection result of a sensor (12) that detects information about the vehicle (1) or the course (200), and a control step of stopping the vehicle (1) so that the vehicle (1) does not enter the banked section (230) when it is determined that there is another vehicle in the banked section (230) based on the detection result of the sensor (12).

Abstract: A vehicle inspection system that images and assesses an automobile or truck during a single passage through an inspection area. Undercarriage, tire, and body imaging assemblies activate at coordinated times to optimally capture photos detailing the vehicle underbody, wheel, and profile views. The system improves imaging precision through targeted illumination and sensor arrays tailored to respective inspection zones. A computational core synchronizes aggregate sensor output to amalgamate a comprehensive perspective of the vehicle with minimized throughput timing. Automated analysis then identifies any defects, wear, or damage across imaging clusters. The system facilitates expedited assessment to categorize large vehicle pool conditions via an integrated mechanics-free apparatus requiring only conventional operator access.

Abstract: A wheel load assembly (5) for a dynamometer test bench (1) comprises—a support structure (17) which can be assembled on a base (12), —a vertical load device (18) having a first application bracket (19) which is rigidly connectable to a bearing body (96), which in turn is couplable to the wheel suspension part (3), a first reaction support (20) connected to the support structure (17), a first force transmission connector (21) connected between the first reaction support (20) and the first application bracket (19), as well as a first load apparatus (22) operatively connected to the first force transmission connector (21) to load the first force transmission connector (21) in a first vertical load direction (23), —a longitudinal load device (24) having a second application bracket (25) which is rigidly connectable to the bearing body (96), which in turn is couplable to the wheel suspension part (3), a second reaction support (26) connected to the support structure (17), a second force transmission connector (27)

Abstract: The invention relates to a leak detection system on board of a vehicle comprising a fuel tank (301, 401), a filler pipe (302, 402), a venting line (303, 403) for recirculating fuel vapors from the tank to the filler pipe, said system having a combination pressure and temperature sensor mounted in the vapor dome of the fuel tank, and a pressure sensor located in the recirculation line above the highest possible liquid level that could be present in the recirculation line and to methods to detect said leak.

Abstract: An intrinsically-safe sensor system, as well as a method for assembling the intrinsically-safe sensor system and a method for monitoring sound corresponding to a source using the intrinsically-safe sensor system, are provided herein. The intrinsically-safe sensor system includes a number of sensors, including a microphone, as well as a processor for processing sensor data obtained from the sensors. The intrinsically-safe sensor system also includes a memory component for storing the sensor data obtained from the sensors, a power source, a communication connection for communicably coupling the intrinsically-safe sensor system to a remote computing system, and a connector including internal and external connection regions for internally and/or externally connecting one or more additional devices to the intrinsically-safe sensor system on demand.

Abstract: A wafer processing apparatus includes a vacuum chuck on which a wafer is seated, a ring cover installed on a circumferential portion of the vacuum chuck, a medium supply part connected to the vacuum chuck to supply an inspection medium to the vacuum chuck, and a sealing ring which is installed in the vacuum chuck to support the wafer and into which the inspection medium supplied to the vacuum chuck is introduced.

Abstract: A method for detecting and preventing leaks of a double-walled container for the storage of poisonous, caustic, irritant and/or combustible media utilizes a double-walled container with an inner wall and an outer wall. A cavity is formed between the inner wall and the outer wall, a positive pressure is generated in the cavity, and in the event of a leak of the inner wall, a gas is fed to the cavity in order to maintain a positive pressure in the cavity. A container system includes an open-loop/closed-loop control device for the open-loop/closed-loop control of a gas throughflow in a line. The system includes a pressure measuring unit for measuring the pressure in the cavity of the double-walled container.

Abstract: A vibration detection device includes an A/D conversion unit for receiving a sine wave signal of an AE wave corresponding to vibration generated in a target machine from an AE sensor that detects the AE wave and converting the received sine wave signal into digital data, an extraction unit for extracting, from the digital data, a data point of a local maximum value for each cycle of the sine wave signal, and an output processing unit for outputting the data point extracted by the extraction unit and cycle data including data points with the number of points which can be recognized as a sine wave and including the data point of a local maximum value so that an output unit visibly outputs the data point and the cycle data.

Abstract: A method for monitoring the status of an apparatus comprises processing in a processor a cyclic signal emitted and/or received by said apparatus, by sampling at least part of a plurality of cycles of the cyclic signal at n points to provide n measured values; comparing the n measured values to a predetermined distribution of values at said n points representing a first state of the apparatus; and if the n measured values fall outside predetermined criteria relating to the predetermined distribution, providing an indication that the apparatus is not in the first state.

Abstract: An automated computer-controlled sampling system and related methods for collecting, processing, and analyzing agricultural samples for various chemical properties such as plant available nutrients. The sampling system allows multiple samples to be processed and analyzed for different analytes or chemical properties in a simultaneous concurrent or semi-concurrent manner. Advantageously, the system can process soil samples in the “as collected” condition without drying or grinding. The system generally includes a sample preparation sub-system which receives soil samples collected by a probe collection sub-system and produces a slurry (i.e. mixture of soil, vegetation, and/or manure and water), and a chemical analysis sub-system which processes the prepared slurry samples for quantifying multiple analytes and/or chemical properties of the sample. The sample preparation and chemical analysis sub-systems can be used to analyze soil, vegetation, and/or manure samples.

Abstract: Various implementations include a device for analyzing total organic carbon (TOC) within a fluid. The device includes a primary container, an input conduit, and an output conduit. The primary container is hollow and has a primary side wall and a primary end wall. The primary side wall has an inner surface defining a primary cavity and an outer surface opposite and spaced apart from the inner surface. The primary end wall includes a septum that is resiliently penetrable by an analyzer needle of a grab analysis port of a TOC analyzer. The input conduit has an input lumen. The input conduit extends through the primary container such that the input lumen is in fluid communication with the primary cavity. The output conduit has an output lumen.

Abstract: Disclosed is a device for contactlessly mixing fluid present on the upper surface of the slide, where the device comprises a first nozzle array and a second nozzle array, the first nozzle array adapted to impart a bulk fluid flow to the fluid present on the upper surface of the slide, and the second nozzle array adapted to impart at least a first regional fluid flow to at least a portion of the fluid present on the upper surface of the slide.

Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.

Abstract: A concentrator includes a casing, a separation membrane that sections an inner space of the casing to form a flow path in the casing, a first supplier that supplies a first liquid from a first position of the casing to the flow path such that the first liquid flows along the separation membrane in a first direction, a second supplier that supplies a second liquid from a second position of the casing to the flow path such that the second liquid flows along the separation membrane in a second direction opposite to the first direction, and a third supplier that supplies a third liquid including a target component having a size that does not allow permeation of the target component through the separation membrane from a third position of the casing to the flow path.

Abstract: A fluid sensor for performing a reference measurement includes a support structure having a top main surface region; a thermal emitter on the top main surface region of the support structure; a first waveguide section and a first thermal radiation detector on the top main surface region of the support structure; and a cover structure on at least one part of the first waveguide section. The first waveguide section guides a first portion of the thermal radiation emitted by the thermal emitter to the first thermal radiation detector. The first thermal radiation detector detects the guided first portion of the thermal radiation for performing the reference measurement.

Abstract: An object is to support evaluation of corrosion of metal embedded in the ground such that the corrosion can be evaluated with high accuracy even if any type of soil is used. A coarseness/fineness test unit analyzes soil particles of soil that is used to evaluate corrosion of an embedded metallic material, a water supply unit supplies water to the soil, a soil stirring unit stirs the soil supplied with water, and a viscosity test unit measures fluidity of the stirred soil.

Abstract: A method for evaluating Dry Eye Disease (“DED”) in a human or animal subject is provided. Thread thinning dynamics of a tear sample of the subject are determined using an acoustically-driven microfluidic extensional rheometry instrument. At least one physical parameter value of the tear sample is calculated based at least in part on the determined thread thinning dynamics. DED is evaluated based at least in part on the at least one calculated physical parameter value of the tear sample. A device for evaluating Dry Eye Disease (DED) in a human or animal subject is also provided. The device includes an acoustically-driven microfluidic extensional rheometry instrument and a processing device configured to evaluate DED based at least in part on the calculated at least one physical parameter value of the tear sample.

Abstract: A viscosity estimation device includes: a current detector detecting a drive current supplied to an induction motor which stirs a substance due to rotation of a rotating shaft which is rotationally driven; a rotation detector detecting rotation of the rotating shaft; and a calculator obtaining a viscosity correlation value, which is a value having a correlation with a viscosity of the substance, using a detection result of the current detector and a detection result of the rotation detector.

Abstract: A system and methods are disclosed. The system includes a temperature control chamber with a temperature system to alter and monitor a temperature of the temperature control chamber and an electromagnetic viscometer (EMV) inside the temperature control chamber to measure a viscosity of a fluid. The system also includes a sample preparation cell within the temperature control chamber pressurized by a constant displacement pump outside the temperature control chamber. The sample preparation cell includes a stirrer; a first valve between a fluid supply reservoir and the sample preparation cell; a second valve between the sample preparation cell and the EMV, a venting fluid line between the sample preparation cell and a gas capturing system, and a venting fluid line to remove released gases from the sample preparation cell. The system further includes a controller to operate the sample preparation cell, temperature system, and EMV.

Abstract: In order to secure measurement reproducibility and a measurement accuracy by making it possible to automatically execute a bubble removal sequence as needed, the particle size distribution measurement device comprises a circulation flow channel through which the dispersion medium circulates, a flow cell arranged in the circulation flow channel, an imaging device that takes a particle image as being an image of a particle in the flow cell, and a bubble removal execution part that obtains bubble information which is obtained based on the particle image and which is about a bubble in the dispersion medium and that executes a bubble removal sequence to remove the bubble from the dispersion medium circulating in the circulation flow channel in case that the bubble information meets a predetermined condition.

Abstract: Provided is a nanosensor having a high dynamic range and sensitivity for detecting the presence, and/or quantifying the amount, of an analyte in a sample of interest. Also provided is a cartridge incorporating the nanosensor, and a method and system for detecting the presence, and/or quantifying the amount, of the analyte in the sample of interest.

Abstract: The disclosure relates to a method for identifying adsorbates deposited on resonance plates. The method includes (i) calculating a candidate mass and candidate position of the adsorbate, disregarding the effect of stiffness, from the measurement of the frequencies of the plate and prior knowledge of the mass of the plate; (ii) using the calculated values as a starting point for calculating the final values of the mass and position of the adsorbate and the different stiffness coefficients from the measurement of the frequencies of the plate; (iii) comparing the values of the candidate mass of the adsorbate and of the calculated coefficients with a set of previously stored reference values corresponding to a catalogue of known adsorbates; and (iv) identifying the adsorbate deposited on the plate as the adsorbate belonging to the catalogue that is most similar to the obtained values.

Abstract: An exemplary embodiment of an apparatus for detecting microbiological activity in an industrial process may include a plurality of satellite units, a processing unit, and a main analysis unit. Each satellite unit may be configured to sample a liquid from the industrial process at a plurality of respective locations, periodically analyse a sample, carry out an impedance analysis to count and measure the size of particles passing through an orifice, and generate sample results data corresponding to the number and size of particles in each sample. The processing unit may be configured to compare the sample results data to a predetermined criterion and to generate an alert signal if the particle data is outside of the predetermined criterion. The main analysis unit may be configured to carry out a combined impedance and electromagnetic emission analysis of a sample of liquid from the industrial process following generation of the alert signal.

Abstract: In an optical measurement method, light is directed from a light generator to a light path cell. A light path is generated by continuously reflecting the light between first and second high reflection mirrors within a light path cell that face to each other. An optical signal is detected from an aerosol sample present within a range of the light path. The optical signal is separated into a particle signal and a gas signal by using a statistical methodology. A particle concentration is calculated from the particle signal by using an assumption of an optical particle counter (OPC). A gas concentration is calculated from the gas signal by using optical characteristic data of gas.

Abstract: A system, method, and apparatus are provided for flow cytometry. In one example, the flow cytometry system includes dual laser devices and dual scatter channels to measure velocity of particles in a core stream of sample fluid. The total flow rate of the sample fluid and the sheath fluid around the sample fluid is controlled, and thus held constant, by a feedback control system controlling a vacuum pump based on differential pressure across ends of a flow channel in the flow cell. A stepper flow control valves are disclosed that apply a physical fluid resistance to a flow of sheath fluid in the flow cytometer. The physical fluid resistance regulates a flow rate of the sheath fluid and thereby regulates a flow rate of sample fluid in the flow cytometer.

Abstract: A measuring device according to the present technology includes a light emitting unit configured to emit light to a fluid, a light receiving unit configured to perform photoelectric conversion for incident light using an electron avalanche phenomenon by a plurality of pixels to obtain a light reception signal, and a control unit configured to perform processing of detecting a target object in the fluid on the basis of the light reception signal and execute an imaging operation of the target object on condition that the target object is detected.

Abstract: Provided are methods of detecting, assessing or determining the presence or absence of particles, such as bead particles, present in a cell composition. Also provided are articles of manufacture and kits for use in the methods.

Abstract: A corrosion amount estimation apparatus includes a soil analysis unit adapted to acquire a particle diameter distribution in soil in each of plural soil samples; a corrosion measurement unit adapted to take electrochemical measurements at plural soil moisture percentage values on an electrode containing the metallic material buried in each of the soil samples; a soil classification unit adapted to classify the soil in each of the soil samples; a corrosion rate calculation unit adapted to calculate a corrosion rate regarding each of the soil samples at each of the soil moisture percentage values and identify a local maximum corrosion rate; a corrosion estimation curve generation unit adapted to generate a corrosion estimation curve; and a corrosion amount estimation unit adapted to acquire the class proportions of actual soil in which the metallic material is buried, acquire the local maximum corrosion rate corresponding to the class proportions from the corrosion estimation curve, and estimate the corrosion a

Abstract: A corrosion sensor is described. The corrosion sensor comprises a substrate 10 and a patterned conductive layer provided on the substrate 10, wherein the conductive layer defines: a common terminal; a set of terminals, including a first terminal and a second terminal; and a set of sensing elements, including a first sensing element and a second sensing element; wherein respective sensing elements of the set thereof are electrically coupled to the common terminal and to respective terminals of the set thereof, such that the respective terminals of the set thereof are specific to the respective sensing elements of the set thereof.

Abstract: A colorimetric sensor for detecting an analyte of interest that includes a metal layer disposed upon a substrate, a plurality of nanostructures, and a corresponding plurality of metal deposits spaced apart from the metal layer. The metal layer defines a plurality of holes, each nanostructure includes a first portion disposed within a respective hole, and each metal deposit is disposed upon a second portion of a respective nanostructure. The sensor also includes a molecularly imprinted polymer layer that may cover the metal layer, the nanostructures, and/or the metal deposits. The molecularly imprinted polymer layer defines a cavity shaped to receive the analyte of interest, and the sensor is configured such that, when an analyte contacts the molecularly imprinted polymer layer and becomes disposed within the cavity, an optical property of at least a portion of the sensor changes thereby to cause a detectable color change in and/or from the sensor.

Abstract: A computer-implemented method to improve the accuracy of a calculation of a biomarker value from a spectral measurement. The computer-implemented method comprises receiving a primary spectral measurement from a primary detector, receiving, a secondary measurement from a secondary detector, and calculating a value of the biomarker using a biomarker algorithm. The biomarker algorithm takes an input from the primary spectral measurement and a calibration parameter from the secondary measurement.

Abstract: A detection apparatus and a detection method. The detection apparatus includes: a main body, a detection assembly, and a detection object receiving portion. The detection assembly includes: a signal transmitter, configured to transmit detection signals; a signal receiver, configured to receive at least part of the detection signals transmitted by the signal transmitter; and a detection connection portion, connected to the signal transmitter and the signal receiver and causing the signal transmitter and the signal receiver to be spaced from each other by the detection connection portion. The detection object receiving portion is configured to receive a detection object. The detection object receiving portion and the detection assembly are relatively movably arranged on the main body so as to allow the detection object received by the detection object receiving portion to be located in a transmission path of the detection signals between the signal transmitter and the signal receiver.

Abstract: An apparatus includes a spectrometer. A housing is attached to a substrate and defines an illumination channel and a receiving channel. The illumination channel includes an illumination source mounted on the substrate and operable to produce light in a particular part of the spectrum. A light pipe is disposed over the illumination source so as to direct light from the illumination source out of the illumination channel toward a target. The receiving channel includes a sensor chip mounted on the substrate. The sensor chip includes light sensitive elements, each of which is selectively sensitive to a respective region of the particular part of the spectrum. The sensor chip further includes an electronic control unit operable to analyze signals from the light sensitive elements.

Abstract: A method for evaluating spectra of a biological substance of animal and/or vegetable origin, may include (a) detecting a spectrometer in a network formed of at least one spectrometer and an input/output device, (b) requesting the individual status of each spectrometer in the network of (a), and displaying the detected spectrometers and their status on the input/output device, the status reflecting if a spectrometer is available for recording a spectrum or not, (c) receiving a selection from the spectrometers being available for recording a spectrum on the input/output device, (d) recording a spectrum of a sample material of animal origin, vegetable origin or a mixture thereof on the spectrometer selected in (c), (e) predicting a value for at least one parameter from the spectrum of (d) by a calibration function and/or calibration graph suitable for predicting the parameter value, and (e) displaying the result from (e) on the input/output device.

Abstract: A device, e.g., sensing cartridge, includes a first member and a second member coupled to the first member. The first member is configured to separate a component from a feed solution, where the component has a hydrodynamic diameter greater than 0.01 micrometers (?m). The second member is configured to wick a permeate from the first member.

Abstract: Systems, apparatuses and methods for rapidly evaluating light transmission through coatings including paints, primers, thin films, surfacing films, laminates and the like are disclosed. The system includes a light source for transmitting light through a coating sample. A sample holder holds the coating sample in a position to receive the incident light. A spectrometer measures an amount of the transmitted light that passes through the coating sample. Optionally, one or more optical filters may be used to condition any transmitted light that passes through the coating sample to reduce the intensity of the light outside of wavelengths of interest. An opaque cover encloses the spectrometer, the one or more optional optical filters, and at least part of the sample holder to prevent light other than the transmitted light from the light source from entering the spectrometer such that any transmitted light passing through the coating sample can be accurately evaluated.

Abstract: A method for determining a measure of a gas concentration from a group of at least two non-dispersive infrared. NDIR. gas sensors (S1-SN) is described. The method comprises the steps of obtaining. at a processing unit (1), from each NDIR gas sensor (S1-SN) a measure of a gas concentration as a belief function Pi(x), which provides a probability as a function of the sensed light intensity at a specific wavelength, merging. in the processing unit, the belief functions Pi(x) to a merged belief function P(x). A computer program performing the method is also described.

Abstract: A terahertz sensing system and a terahertz sensing array are provided. The terahertz sensing array includes N sensing unit groups arranged in an array form, and each of the N sensing unit groups includes M reconfigurable sensing units. Each of the M reconfigurable sensing units can detect one type of terahertz wave physical characteristic parameter, and the type of the terahertz wave physical characteristic parameter that can be detected by the reconfigurable sensing unit may vary based on a detection configuration, where N and M are positive integers greater than 1.

Abstract: Systems and methods for imaging cells. Quantitative phase imaging uses variations in the index of refraction of a sample as a source of endogenous contrast, providing label-free information of sub-cellular structures and allowing for the reconstruction of valuable biophysical parameters, such as cell dry-mass at femtogram scales, mass transport, and sample thickness and fluctuations at nanometer scales. As a result, QPI has become a valuable tool in biology and medicine. However, QPI has suffered from the need for trans-illumination through relatively thin objects in order to gain access to the forward-scattered field, which carries crucial low spatial frequency information of a sample and avoid contributions from multiple scattered light or out-of-focus planes. The disclosed methods and systems can provide for reconstruction of QPI and corresponding analysis for imaging samples of cells in thick samples using an epi-illumination configuration.

Abstract: A method of measuring rinse properties of a composition from a surface, the method includes providing a cosmetic treatment composition. The method also includes applying the cosmetic treatment composition to a surface. The method also includes rinsing the surface with a first amount of water after applying the cosmetic treatment composition to the surface. The method also includes collecting a portion of the first amount of water after rinsing the surface with the first amount of water. The method also includes measuring a first turbidity of the portion of the first amount of water after collecting the portion of the first amount of water.

Abstract: Exemplary computer-accessible medium, systems, and methods are described herein which can provide an excited fluorescence radiation. In accordance with certain exemplary embodiments of the present disclosure, an excited fluorescence radiation can be provided using a beam of a probe so as to excite a molecule to an excited state for a fluorescence emission to effectuate the excited fluorescence radiation. The molecule can be detected based on the fluorescence emission. For example, the beam of the probe can be either the near-infrared spectrum or the visible light spectrum.

Abstract: An integrated detection, flow cell and photonics (DFP) device is provided that comprises a substrate having an array of pixel elements that sense photons during active periods. The substrate and pixel elements form an IC photon detection layer. At least one wave guide is formed on the IC photo detection layer as a photonics layer. An optical isolation layer is formed over at least a portion of the wave guide. A collection of photo resist (PR) walls patterned to define at least one flow cell channel that is configured to direct fluid along a fluid flow path. The wave guides align to extend along the fluid flow path. The flow cell channel is configured to receive samples at sample sites that align with the array of pixel elements.

Abstract: An analysis tool for use in optical analysis, comprising a detection unit 10 having through-holes 10h penetrating through the surface and the rear side of a base material 11, the detection unit 10 comprising, inside of the base material 11, a plurality of voids 11h that allows a liquid to pass through by capillary action and that communicate with the through-holes 10h, and the through-holes 10h being formed with a size that enables a liquid to be held by surface tension. Therefore, by irradiating the detection unit 10 with light, it is possible to obtain transmitted light L2 that has been transmitted through a liquid film Lf. By analyzing the transmitted light L2, a target component in a sample L can be appropriately quantified.

Abstract: Biosensor including a device base having a sensor array of light sensors and a guide array of light guides. The light guides have input regions that are configured to receive excitation light and light emissions generated by biological or chemical substances. The light guides extend into the device base toward corresponding light sensors and have a filter material. The device base includes device circuitry electrically coupled to the light sensors and configured to transmit data signals. A passivation layer extends over the device base and forms an array of reaction recesses above the light guides. The biosensor also includes peripheral crosstalk shields that at least partially surround corresponding light guides of the guide array to reduce optical crosstalk between adjacent light sensors.

Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.