Abstract: There is provided a disclosure in which a specimen is analyzed with high accuracy. An information processing device includes an extraction unit that extracts fluorescence correction information from a bright visual field image of the specimen, and a generation unit that generates a fluorescence correction image based on fluorescence information of the specimen and the fluorescence correction information.

Abstract: The present invention relates to a surface-enhanced Raman scattering patch and an attachable sensor using same. More particularly, the present invention relates to a surface-enhanced Raman scattering patch which allows continuous monitoring of drug administration and harmful substance detection to be accurately and easily performed, an attachable sensor using same, and a method for manufacturing same.

Abstract: The present disclosure relates to a surface-enhanced Raman spectroscopy complex probe capable of effectively detecting a catecholamine compound even at extremely low concentrations. The complex probe includes a nanolaminate including a nanogap and metal nanoparticles. In this case, the nanolaminate and the metal nanoparticles are modified to a compound that may be bound to each functional group included in catecholamine, and thus, catecholamine included in an analyte is doubly recognized by the complex probe. In addition, since a hotspot emitting a strong SERS signal is formed by a nanogap included in a nanolaminate, it is possible to effectively detect a catecholamine compound even at extremely low concentrations.

Abstract: Methods are provided for making a membrane or textile having a mechanically robust surface-enhanced Raman spectroscopy (SERS) substrate by in a first step adhesively bonding a micropatch array to a substrate, the micropatch array having a plurality of micron-scale pillars, each of the micron-scale pillars in the plurality of micron-scale pillars containing a plurality of plasmonic nanoparticles dispersed within a polymer matrix; and in a subsequent step etching a portion of the polymer matrix to expose at least a portion of the plasmonic nanoparticles at or near a surface of the micron-scale pillars. Membranes and textiles containing the mechanically robust surface-enhanced Raman spectroscopy (SERS) substrates are also provided.

Abstract: A polymer dye includes at least one repeating unit represented by the following structural formula 1 and at least one selected from the group consisting of repeating units represented by the following structural formulas 2 and 3: Hydrogen peroxide present in or generated through enzymatic reaction in a biological sample can be detected by using the polymer dye.

Abstract: A photoluminescent material can be applied to part of a substrate as part of substrate inspection. The photoluminescent material includes a conjugated polymer having a coiled macroscopic molecular shape and a meta-linkage or an ortho-linkage. The substrate is imaged using an inspection system. The conjugated polymer can be, for example, poly(m-phenylene ethynylene) (PPE) or poly(para-phenylene vinylene) (PPV).

Abstract: A method for determining soil moisture of a scene includes (i) generating a first antenna output in response to an upwelling thermal emission from the scene, (ii) generating a second antenna output in response to a downwelling thermal emission from sky above the scene, (iii) coupling the first antenna output and the second antenna output to yield a combined output having a quadrature phase difference between the first antenna output and the second antenna output, (iv) calculating a brightness-temperature difference based at least partially on the combined output, and (v) calculating a soil moisture based on soil-vegetation radiative transfer model using the brightness-temperature difference.

Abstract: Provided is a dynamic imaging quality control device that performs quality control concerning dynamic imaging in which dynamics of a subject is imaged by sequential radiation emissions to the subject. The dynamic imaging quality control device includes a hardware processor. The hardware processor presents information on the quality control. The information on the quality control includes at least one of information on a framerate, information on a system sensitivity, and information on an image region.

Abstract: Provided are an image processing apparatus, a radiography system, an image processing method, and an image processing program by which a radiographic image can be accurately corrected. An image processing apparatus includes an image acquisition unit that acquires, from a radiation detector in which a plurality of pixels each of which outputs an electrical signal according to a dose of radiation R emitted from a radiation source are arranged, a radiographic image captured in a state in which end parts of the radiation detector overlap with each other; and a correction unit that corrects an influence of the end portion on a far side from the radiation source, which is included in the radiographic image.

Abstract: A means is provided for enabling easy identification of baggage in which one or more hazardous item is detected. An inspection system is equipped with a first conveyor, inspection device, cover, camera, controller and display. The first conveyor transports baggage to the inspection device. The inspection device captures transmitted-light images of the baggage using light that transmits through the baggage. The cover covers a transport path of the baggage to prevent a hand of a visitor from being inserted into an image shooting area where electromagnetic waves that are harmful to the human body are irradiated. The camera captures visible-light images of the baggage using visible light. The controller controls the first conveyor, inspection device, camera and display. Under control of the controller, the display simultaneously displays a transmitted-light image and a visible-light image of the baggage.

Abstract: A gas sensor includes: a substrate; a first conductor and a second conductor that are disposed on the substrate; an insulating layer; and an adsorbent layer. The insulating layer covers the first conductor and the second conductor, and has a first opening that allows a part of a surface of the first conductor to be exposed therethrough and a second opening that allows a part of a surface of the second conductor to be exposed therethrough. The adsorbent layer contains a conductive material and an organic adsorbent that can adsorb a gas. The adsorbent layer is in contact with the first conductor and the second conductor respectively through the first opening and the second opening.

Abstract: A method for identifying damage in a component of a wind turbine includes placing a conductive element onto at least one surface of the component of the wind turbine. The method also includes electrically connecting the conductive element into an electrical circuit. Further, the method includes monitoring a status of the electrical circuit to identify the damage in the component. In particular, when the status of the electrical circuit is open, damage is likely present in the component, and when the status of the electrical circuit is closed, damage is unlikely present in the component. Moreover, the method includes transmitting the status of the electrical circuit to a user interface for display.

Abstract: A method for manufacturing a sensor includes etching an insulator layer disposed over a substrate to define an opening exposing a sensor surface of a sensor disposed on the substrate, a native oxide forming on the sensor surface; sputtering the sensor surface with a noble gas to at least partially remove the native oxide from the sensor surface; and annealing the sensor surface in a hydrogen atmosphere.

Abstract: A bio sensor using a FET element and an extended gate, and an operating method thereof are disclosed. A biosensor using a field effect transistor (FET) device and an extended gate electrode according to the present invention is characterized by comprising: an extended gate electrode connected to the FET element; a sensing electrode made of the same material as the extended gate electrode and on which a receptor antibody selectively recognizing a target molecule is fixed; and a reference electrode that maintains a constant potential and is selectively connected to the sensing electrode.

Abstract: Various cell analysis systems of the present teachings can measure the electrical and metabolic activity of single, living cells with subcellular addressability and simultaneous data acquisition for between about 10 cells to about 500,000 cells in a single analysis. Various sensor array devices of the present teachings can have sensor arrays with between 20 million to 660 million ChemFET sensors built into a massively paralleled array and can provide for simultaneous measurement of cells with data acquisition rates in the kilohertz (kHz) range. As various ChemFET sensor arrays of the present teachings can detect chemical analytes as well detect changes in cell membrane potential, various cell analysis systems of the present teachings also provide for the controlled chemical and electrical interrogation of cells.

Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

Abstract: A gas sensor includes a measurement chamber, a reference gas chamber, a first cell, and a second cell. The first cell includes a first electrode in the measurement chamber and a second electrode in the reference gas chamber. The second cell includes a third electrode in the measurement chamber and a fourth electrode in the reference gas chamber. A gas sensor detects a first current that flows between the first electrode and the second electrode, detects a second current that flows between the third electrode and the fourth electrode, calculates a concentration of a specific gas component based on a detected value of the second current, estimates a change amount of oxygen concentration in the reference gas chamber based on a detected value of the first current, and corrects the detected value of the second current based on an estimated value of the change amount of the oxygen concentration.

Abstract: The present disclosure relates to a microorganism detection apparatus using a dielectrophoresis (DEP) force. A microorganism detection apparatus according to one embodiment of the present disclosure may include a detection unit that detects microbial particles using a DEP force corresponding to latex particles combined with the microbial particles.

Abstract: To form a layer separating two volumes of aqueous solution, there is used an apparatus comprising elements defining a chamber, the elements including a body of non-conductive material having formed therein at least one recess opening into the chamber, the recess containing an electrode. A pre-treatment coating of a hydrophobic fluid is applied to the body across the recess. Aqueous solution, having amphiphilic molecules added thereto, is flowed across the body to cover the recess so that aqueous solution is introduced into the recess from the chamber and a layer of the amphiphilic molecules forms across the recess separating a volume of aqueous solution introduced into the recess from the remaining volume of aqueous solution.

Abstract: A defect detection method includes: a step of irradiating an object with a pulsed laser beam to continuously generate ultrasonic waves in the object; and a step of detecting the presence or absence of an internal defect of the object on the basis of the presence or absence of resonance of the ultrasonic waves occurring between a surface of the object and the internal defect. In this method, the internal defect is detected on the basis of the presence or absence of resonance of the ultrasonic waves occurring between the surface of the object and the internal defect. The internal defect can be thus detected even when the internal defect is in a surface layer of the object. The detected internal defect is crack or void.

Abstract: Methods for non-destructive testing of engineering materials. In one aspect, a method can be used to calculate residual longitudinal and annular welding stresses in welded joints and can be used to assess the quality of pipeline welds according to the criterion of the level of residual stresses and to determine the initial parameters for the pipeline strength calculation. In some aspects, the method enables independent calculation of the longitudinal and hoop residual stresses. Thus, the stresses can be calculated in the seam metal of the pipelines welds, where they reach their maximum values. The method can be used to test a pipeline section using an ultrasonic echo method to measure the propagation time for longitudinal waves and transverse waves polarized along and across the pipe axis. The measurement results define the distinguishing features of the stress state of a welded joint for a specific type of pipe by numerical modeling.

Abstract: A piezoelectric sensor for sensing an ovalling mode in a cylindrical structure, a non-destructive testing system for determining the strength condition of the cylindrical structure, and a method for non-destructive testing of the cylindrical structure are provided. The piezoelectric sensor includes an H-shaped caliper with a first and second arm, connected by a crossbar, and has a caliper connector near first end of each arm and a wire connector near second end of each arm. A piezoelectric wire is connected and stretched between the wire connectors and is connected to an electrical terminal to provide electrical signal in response to expansion and contraction as a result of vibrations induced in the cylindrical structure. The system includes a measurement unit connected to the electrical terminal, to receive and perform a frequency analysis of the electrical signal based on the ovalling mode and output a stiffness value of the cylindrical structure.

Abstract: A method is provided for determining the geometry of a metallic object, with in particular one or more real, examined defects, with a reference data set of the object generated on the basis of at least one measurement by at least one non-destructive measuring method, preferably comprising an at least partial representation of the object on or by an at least three-dimensional object grid by means of a computer unit. A classification of anomaly-free areas and anomaly-affected areas of the object is performed on the basis of at least parts of the at least one reference data set.

Abstract: Ultrasonic probes are provided to abate unwanted signal noise. An ultrasonic probe includes a bundle of rods configured to sample data at a first end and propagate a signal encoding the sampled data to a second end. Each of the rods in the bundle of rods has a substantially similar length and a substantially similar diameter. The ultrasonic probe also includes a shell concentrically disposed around the bundle of rods. The shell is configured to pack the bundle of rods together. The shell includes a plurality of grooves configured to abate a prevailing bulk wave sampled by the first end.

Abstract: The system includes an ultrasonic measuring device including ultrasonic transmitters and ultrasonic receivers, the ultrasonic measuring device carrying out ultrasonic measurements on a zone of interest of the component divided according to a gridding including cells, and carrying out the measurements cell after cell with the generation, by all the ultrasonic transmitters, of an ultrasonic signal that is sent into the component, and the measurement, by all the ultrasonic receivers, of the amplitude of the ultrasonic signal reflected by the cell in question of the component, a unit for computing, for all of the cells of the gridding, the sum of the amplitudes of all the measurements carried out for that cell, and a processing part for deducing the presence or absence of one or more defects. The system detects all the defects existing in the zone of interest of the component, whatever their orientation may be.

Abstract: A method and system for analysing a condition of a pipeline in real time is disclosed. The method and system comprise generating a transient pressure wave in fluid carried along the pipeline and detecting a transient pressure wave interaction signal responsive to the transient pressure wave where the pressure wave interaction signal has a time duration corresponding to a region of interest of the pipeline. The method and system further includes processing the transient pressure wave interaction signal to analyse the region of interest of the pipeline.

Abstract: A multiple degree of freedom sample stage or testing assembly including a multiple degree of freedom sample stage. The multiple degree of freedom sample stage includes a plurality of stages including linear, and one or more of rotation or tilt stages configured to position a sample in a plurality of orientations for access or observation by multiple instruments in a clustered volume that confines movement of the multiple degree of freedom sample stage. The multiple degree of freedom sample stage includes one or more clamping assemblies to statically hold the sample in place throughout observation and with the application of force to the sample, for instance by a mechanical testing instrument. Further, the multiple degree of freedom sample stage includes one or more cross roller bearing assemblies that substantially eliminate mechanical tolerance between elements of one or more stages in directions orthogonal to a moving axis of the respective stages.

Abstract: A device for providing improved measurements of logs. The device includes a feed path of the logs, configured to feed the logs in a direction orthogonal to the axis of the logs; and one or more pick-up members spaced from one another in a direction transverse to the feed path of the logs. The pick-up members are adapted to pick up individual logs from a pick-up position along the feed path; and transfer each log from the measuring position back to the feed path substantially in the position in which it was picked up.

Abstract: A bench for mechanical characterisation of a battery cell by applying a compression force includes a frame having a first compression plate, a movable element having a second compression plate opposite the first compression plate, a compression spring for applying a compression force to the cell between the first and second compression plates, a force sensor inserted between the movable element and the spring, and movement sensors measuring the movement between the first and second compression plates. The first compression plate includes a projecting compression zone with an area equal to a portion of interest of the cell and the frame includes a recess surrounding a thicker frame in the frame forming a pedestal supporting the first compression plate.

Abstract: A dual indentation test method according to an aspect of the present disclosure may include a first indentation step of indenting a surface of a material using a flat first indenter and a second indentations step of indenting the surface of the material indented by the first indenter using a second indenter.

Abstract: A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

Abstract: A multi-dimensional gas chromatograph for analyzing compounds in a sample during a single run is disclosed. The multi-dimensional gas chromatograph includes a first column, a second column, and a modulator disposed between the first column and the second column. The modulator modulates at (i) a first modulation period over a first time period during the run and (ii) a second modulation period over a second time period during the run later than the first time, the second modulation period being different than the first modulation period.

Abstract: A mass spectrometry method comprises: providing a multiplexed sample comprising a mixture of biomolecule-containing samples respectively tagged with mass tags; acquiring MS2 spectra by data-dependent acquisition (DDA) of the multiplexed sample or another mass tagged mixture of the samples during chromatographic elution; acquiring MS2 spectra by data-independent acquisition (DIA) during the elution; forming a spectral library from the DDA MS2 spectra comprising a plurality of the MS2 spectra and the biomolecule retention times; matching fragment-ion peaks in the DIA MS2 spectra to fragment-ion peaks in the MS2 library spectra to find matched biomolecules; determining a total abundance for each matched biomolecule from the DIA MS2 spectra at each of a plurality of retention times; determining abundances of respective reporter ions from the DIA MS2 spectra at the plurality of retention times; and deconvoluting relative abundances of the biomolecules in each respectively tagged biomolecule-containing sample based

Abstract: Systems and methods for analyzing groundwater samples with multiple organic tracer species from a petroleum containing reservoir include obtaining the sample, isolating an aqueous fraction of the groundwater sample, separating the aqueous fraction into a plurality of components, where each component corresponds to a different one of the organic tracer species, combining each of the separated components with at least one lanthanide element to form a plurality of component solutions, where a ratio of the at least one lanthanide element to the separated component in each component solution is 5:1 or greater, and analyzing each component solution to determine a relative amount of each organic tracer species in the groundwater sample.

Abstract: A controller of the gas sensor can perform diagnostic processing of diagnosing a situation of control to the gas sensor in a case that the gas sensor in an operation state is determined to satisfy a predetermined diagnostic condition and adjustment processing of adjusting a condition for controlling the gas sensor in accordance with a result of diagnosis. In the diagnostic processing, a main pump voltage and a diagnostic threshold as a value of a voltage not causing decomposition of NOx in the main pump cell are compared. In the adjustment processing, temperature adjustment processing to cause, in a case that the main pump voltage is diagnosed to be equal to the threshold or more, the main pump voltage to be less than the threshold, at least in a way that the heater part increases the element driving temperature in the operation state by a predetermined increase amount is performed.

Abstract: The coastal ecosystem carbon pool estimation method of the invention belongs to the field of environmental assessment, and includes the following steps: (a) determining the spatial boundary of the coastal ecosystem; (b) determining the dominant plant classification area of the coastal ecosystem; (c) calculating the carbon source of the freshwater plant dominant area; (d) size setting of carbon source sampling point in coastal ecosystem; (e) sampling method of carbon source sampling point in coastal ecosystem; (f) carbon source estimation method in coastal ecosystem.

Abstract: A method for a three-dimensional temperature and salinity field, including: based on multi-source marine environmental data, analyzing the spatiotemporal distribution characteristics of marine dynamic environmental elements, and studying the characteristics of the temperature-salinity relation; on the basis of analysis of the spatiotemporal characteristics and study of the characteristics of the temperature-salinity relation, establishing a statistical prediction model of marine environmental dynamic elements by a spatiotemporal empirical orthogonal function method; based on the observation data of temperature and salinity obtained by the marine transportation platform, correcting a marine environment forecast field around the marine transportation platform by using a realtime analysis technology of a marine environment field; and adjusting the salinity using a temperature-salinity relation curve after the temperature and salinity are forecasted.

Abstract: Compositions and methods for determining the origin location of subterranean rock samples. In some implementations, the compositions include a nanoparticle tag that includes a natural polysaccharide, a fluorescent dye, and superparamagnetic nanoparticles. In some implementations, a method of determining the origin location of a subterranean rock sample includes mixing the nanoparticle tag into a fluid, flowing the fluid into a subterranean formation, recovering subterranean rock samples from the formation, separating tagged rock samples from untagged rock samples using a magnet, and determining the origin location by analyzing a fluorescent signal of the nanoparticle tag.

Abstract: A lysimeter device used for monitoring and measuring the concentration of water soluble compounds in the soil without disturbing the natural flow pattern of water in the soil and constructed of two tubes, the first tube inserted into the second tube, a sealing plate and a clogging prevention component (CPC). A lysimeter device for monitoring the concentration of soluble fertilizer' compounds, total salinity and pesticides commonly used in agriculture and gardening and their uptake by plants while not disturbing the plants roots soil environment and with no need for an external power/energy source for functioning.

Abstract: A method for evaluating a production potential for volume fracturing of a shale oil reservoir and determining a soaking time is discloses. The method may comprise: obtaining a core column; performing a saturated oil treatment on the core column; obtaining an initial fracture porosity parameter of the saturated oil-treated core column; soaking the core column after a CT scanning into a fracturing fluid to test the core mass increase amount at different immersion durations; obtaining the fracture porosity increase amount of the core column at different soaking times, and calculating a weight of newly added fracture porosity-fillable fracturing fluid; generating a curve of the core mass increase amount and a curve of the weight of the newly added fracture porosity-fillable fracturing fluid at different immersion durations; comparing a mass increase amount per volume unit of a core, and ranking a e mass increase amount per volume unit of the core to determine the production increase potential.

Abstract: A method and a system for predicting a molecular weight of a hydrocarbon fluid are provided. An exemplary method includes measuring a density of the hydrocarbon fluid, obtaining an alternative measurement of a physical property of the hydrocarbon fluid, calculating an index value for the hydrocarbon fluid from the alternative measurement, and calculating a predicted molecular weight using an equation that combines the density with the index value. The predicted molecular weight is provided as an output.

Abstract: A calculation method for service life of concrete in a plateau environment considering protection and restoration effects is provided and includes a construction of a model based on a coupling effect of multi-factors of temperature-humidity-salt concentration-load under the plateau environment, simulation of protection and restoration effects, and quantification of service life. The model includes the physical fields of temperature conduction with variable boundary conditions, water dry-wet cycle transport, salt ion transport, and force fields caused by internal and external loads. The simulation of protection and restoration effects include: surface protective coating, damage restoration, and rebar corrosion resistance.

Abstract: A nanopore system provided herein includes first and second fluidic reservoirs in fluidic communication with a nanopore forming a fluidic path between the reservoirs. An enzyme clamp, provided in the first fluidic reservoir, abuts the nanopore and is reversibly bound to a sequential plurality of polymer subunits of a target polymer molecule in ionic solution. The clamp has an outer clamp diameter that is greater than the nanopore diameter. An electrical circuit includes an electrode in each of the reservoirs for applying a voltage bias across the nanopore. A pulse generator is connected in the electrical circuit to apply control pulses across the nanopore to step the clamp along sequential polymer subunits of the target polymer molecule. The system includes no fuel or source of fuel for the clamp. A controller is connected in the electrical circuit for controlling the collection of electrical indications of polymer subunits.

Abstract: A target cell statistical method, apparatus and system are provided. A cell image of a blood specimen is acquired by a cell image analysis apparatus. The blood specimen is derived from a blood sample to be tested. A number of target cells and a number of reference cells in the cell image are automatically identified by the cell image analysis apparatus. A number of reference cells in the blood sample to be tested is acquired by the cell image analysis apparatus, and a number of target cells in the blood sample to be tested is calculated by the cell image analysis apparatus, based on the number of target cells and the number of reference cells in the cell image and the number of reference cells in the blood sample to be tested.

Abstract: A gas detection system includes a sensor unit that outputs a voltage corresponding to a concentration of a specific gas, a first chamber capable of storing a supplied sample gas, a second chamber located between the first chamber and the sensor unit, and a flow path connectable to an inlet of the second chamber. The second chamber has a smaller area than the first chamber in a cross section perpendicular to a gas flow direction in the first chamber. The sample gas is supplied from the first chamber to the second chamber, and then a purge gas is supplied from the flow path to the second chamber to supply the sample gas to the sensor unit.

Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.

Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.

Abstract: The present invention includes methods, systems, and kits, for identifying and modifying the treatment of a systemic lupus erythematosus (SLE) patient prior to the presence of autoantibodies, comprising: (a) obtaining a dataset representing protein expression level values for cytokines and molecules; (b) assessing the dataset for protein expression levels of at least one innate serum mediator; (c) assessing the dataset for protein expression levels of at least one adaptive serum mediator; and (d) determining the likelihood that the patient will develop SLE prior to the onset of autoantibodies when compared to a control.

Abstract: Described herein are novel fluorescent sensors for cyclic adenosine monophosphate (cAMP) that are based on single fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.

Abstract: The present invention relates to a non invasive diagnostic method of pancreatic ductal adenocarcinoma (PDAC) in a subject said method comprising the step of measuring the level of ?ig-h3 protein in a blood sample wherein the serum level of ?ig-h3 is positively correlated with the risk of having a PDAC. By following studies on 2 distinct cohorts of 20 and 104 of PDAC patients, and on PDAC mouse model, the inventors show that ?ig-h3 can be directly detected in the blood sample and ?ig-h3 is expressed very early in tumorigenesis in pancreatic neoplastic lesions. The present invention also relates to antagonist of ?ig-h3 protein, for use in the treatment of PDAC. The inventors found that ?ig-h3 bind directly on CD8+ T cells by reducing their activation and cytotoxic properties. Furthermore, the use of neutralizing ?ig-h3 antibodies in PDAC mouse model, reduced tumor growth by enhancing CD8+ T cell anti-tumoral response.