Abstract: The present invention provides an inhalation device system for the inhalative administration of a medically active liquid in nebulized form, the system comprising an inhalation device (20) and an exchangeable reservoir (30) for holding a plurality of doses of the medically active liquid, wherein one dose of the medically active liquid is dispensed from the inhalation device per actuation of the inhalation device system, wherein the inhalation device (20) comprises—a housing (21) having a receiving unit (23), the receiving unit having a connection unit (24) adapted to releasably and fluidically connect to a connection port (31) of the exchangeable reservoir (30), the receiving unit (24) being adapted to receive and fluidically connect to the exchangeable reservoir (30); —a nozzle (25) for the nebulization of the medically active liquid; and—a pumping unit (40) arranged within the housing (21) and adapted to be fluidically connected to the exchangeable reservoir (30) and to the nozzle (25) and being adapted to

Abstract: Provided herein are intranasal fluid delivery devices and apparatus comprising a dispensing tip a shot chamber carrying a fluid, the shot chamber having a diaphragm at one end and a plunger at the other end, an actuator connected to a push rod moveable toward the shot chamber, and a sheath covering at least a distal end of the dispensing tip, wherein the distal end of the dispensing tip is configured to extend from the sheath and into a subject's nasal cavity.

Abstract: An inhaler (100) has an actuator (118) configured to interact with a container (110) to selectively release a substance for inhalation. A controller (112) is provided and configured to switch the inhaler between a locked and an unlocked condition. A motion sensor (114) is attached to the inhaler. The controller (112) is configured to store a predetermined motion sequence, and upon detection of the predetermined motion sequence by the motion sensor, the controller is configured to switch the inhaler from the locked condition to the unlocked condition.

Abstract: An apparatus for vaporizing a concentrate and/or a non-concentrate material is provided. The apparatus can include a housing, a reservoir, a vessel, and a heating element. The reservoir can be coupled to a lid of the apparatus and configured to hold the concentrate. The vessel can be disposed at least partially inside of the housing and can be configured to receive the reservoir when the lid of the apparatus is in a closed position with respect to the housing. The heating element can be configured to generate heat for heating the vessel, thereby vaporizing the concentrate in the reservoir to form an aerosol. Coupling the reservoir to the lid of the apparatus can enable the apparatus to be used for vaporizing the concentrate while decoupling the reservoir from the lid of the apparatus can enable the apparatus to be used for vaporizing the non-concentrate material. Related methods are also provided.

Abstract: A method and a system for addressing hyperventilation based on a ventilator device execute steps of: obtaining a carbon dioxide partial pressure of a subject, and determining whether the subject has respiratory alkalosis based on the carbon dioxide partial pressure; obtaining vital sign data of the subject when the respiratory alkalosis occurs and determining a degree of the respiratory alkalosis based on the vital sign data; and adjusting a mixing ratio of oxygen and carbon dioxide based on the degree of the respiratory alkalosis, then re-supplying the subject, and monitoring a respiratory status in real time. The system can quickly and accurately determine whether a subject has respiratory alkalosis by monitoring the carbon dioxide partial pressure, and can effectively alleviate respiratory alkalosis by adjusting mixing ratio of oxygen and carbon dioxide, thus improving the efficiency and safety of resolving respiratory alkalosis caused by hyperventilation.

Abstract: Medical techniques include systems and methods for administering a positive pressure ventilation, a positive end expiratory pressure, and a vacuum to a person. Approaches also include treating a person with an intrathoracic pressure regulator so as to modulate or upregulate the autonomic system of the person, and treating a person with a combination of an intrathoracic pressure regulation treatment and an intra-aortic balloon pump treatment.

Abstract: A respiratory therapy device that is adapted to matingly, frictionally connect with dimensionally standardized devices and device adaptors, that when combined, allow for respiratory treatments. It monitors the direction of the air and or medicament flow (gases) in the device and can visually report as well as record the number of PEP treatment events or the number of medicament administrations by utilizing at least one bidirectional motion sensor therein. It presents a visual and optional auditory alert when the patient's respiratory treatment is not adhered to within waking hours.

Abstract: A removable tracheostomy cannula monitor for monitoring, displaying, and alerting on medical situation of a patient using a cannula. The cannula monitor connects to a cannula. In some embodiments, the cannula monitor also connects to an additional medical device, such as an external ventilation unit. Also in some embodiments, the cannula monitor sends data to a smart phone and/or the patient's electronic medical/health records for processing, display, and communication with a care giver.

Abstract: A cannula holder capable of being used for various patients with different lengths around the necks and for securing a cannula to a neck of a patient with a tracheostomy includes a first belt and a second belt. The first belt includes: a long strip-shaped first body with an inner and outer surface; and a first hook-and-loop fastener protruding from the first body tip end and is inserted into a first slit of the cannula holder. The second belt includes: a long strip-shaped second body, shorter than the first body, and an inner and outer surface; a second hook-and-loop fastener protruding from second body tip end and is inserted into a second slit of the cannula holder; and a third hook-and-loop fastener that is secured within a range of the second body inner surface to be stuck on the outer surface of the first body.

Abstract: A patient interface is disclosed that includes: a plenum chamber; a first connection portion; a seal-forming structure constructed and arranged to seal with a region of the patient's face; a chassis; a second connection portion positioned on the chassis and configured to releasably connect to the first connection portion; a sealing lip to seal between the plenum chamber and the chassis; a positioning and stabilising structure; and a vent structure.

Abstract: An oronasal cushion includes a nasal structure and an oral structure that are connected to each other. A penetrating cavity is formed inside the nasal structure and the oral structure. The cavity can receive pressurized gas. The nasal structure fits around a wearer's nostrils to seal. The oral structure fits around the wearer's mouth to seal. The nasal structure is configured to not pinched against the wearer's nose when sealed against the wearer's nose base by means of pressurized gas. The oral structure is configured to accommodate and fit around the wearer's mouth in response to the oronasal cushion being put on by the wearer. The oral structure includes an oral soft pad in contact with the wearer's face and a reinforcing structure connected to the oral soft pad.

Abstract: A patient interface comprises a plenum chamber and a seal-forming structure. The seal-forming structure comprises a support structure arranged to support a sealing portion that is adapted to sealing engage the patient's face in use. The seal-forming structure may also include a seal biasing portion configured to inflate under pressurization within the cavity in the cushion assembly in use to extend the reach of the sealing portion and decouple the sealing portion from external forces.

Abstract: Various embodiments of an erector spinae regional pain indwelling catheter device and method of use are described. A device can include a flexible tubular body having a wall extending a length from a proximal end to a distal end forming a main lumen with an inner diameter, a portion of the wall of flexible tubular body being fenestrated at the distal end. The device can further include a cord secured to the flexible tubular body and extending from the distal end of the flexible tubular body. The device can also include an anchor suitable for fixation to bone, where the anchor comprises an anchor body and an aperture formed in the anchor body and wherein the cord is received in the aperture formed in the anchor body to detachably connect the distal end of the flexible tubular body to the anchor.

Abstract: A medical procedure kit includes a first tray. A second tray situates atop the first tray. The second tray includes preformed compartments configured to receive and house a plurality of medical implements. A Foley catheter positioned within a Foley catheter compartment of the plurality of preformed compartments of the second tray. A drainage system stowed within an interior of the first tray. A third tray can be situated atop the second tray. The second tray can include a plurality of catheter retention devices. A planar substrate can be positioned beneath the first tray. A Foley catheter compartment can define a barrier wall extending across a majority of its length. A cutout in the second tray and another cutout in the first tray can be positioned at opposite ends of the kit. These features can be used alone or in combination, and many can even be applied to a single-layer tray.

Abstract: The invention relates to a catheter device, having a catheter, an actuation device at a first end of the catheter and also a mechanical transmission element for transmitting a movement along the catheter to the actuation device, the actuation device having a coupling element which is connected to the transmission element and can be actuated by the latter relative to the longitudinal direction of the catheter in a first degree of freedom, and also a conversion element which can be actuated by the coupling element and which converts the actuation movement at least partially into a movement in a second degree of freedom. As a result, a combined movement at the distal end of the catheter can be produced particularly simply for compression and release of a functional element.

Abstract: The invention relates to a drive module (3) of a catheter robot, for driving the translation of a plurality of elongate flexible medical instruments, comprising: a mechanism for driving the translation of a plurality of elongate flexible medical instruments; and a device (5) for the convergence, between a plurality of guide tracks (32) for respectively guiding the translation of a plurality of elongate flexible medical instruments, towards a common exit track (33) shared by these elongate flexible medical instruments, comprising: track connectors which are respectively located between these guide tracks (32) and the exit track (33) and which ensure continuity in the guidance of these elongate flexible medical instruments respectively between these guide tracks (32) and the exit track (33), these track connectors being retractable.

Abstract: Apparatus (100) for facilitating a procedure on a subject, the apparatus comprising a catheter that comprises a head (131); a tube (102) comprising a proximal region (106), coupled to the head; a steering region (110), distal from the proximal region, and dimensioned for advancement into the subject; a bearing surface (266, 268) at the steering region; and a circumferential wall (104) extending from the proximal region to the steering region; and a wire (140, 180), wherein the wire: extends, from the head, distally to the bearing surface, is slidable over the bearing surface, curves around the bearing surface and proximally away from the bearing surface, and has a terminus (158) that is anchored to the tube at an anchoring location (162). Other embodiments are also described.

Abstract: A catheter interface protection device can include a shield. The shield can include an open bottom, a transparent upper surface, sidewalls, and a cavity at least partially defined by the bottom, the upper surface, and the sidewalls. The device can include a vent. The device can include a clip, a tether, and a latch. A non-therapeutic method of protecting a catheter interface can include extending a catheter in the subject through a slot in a catheter interface protection device, wrapping the catheter at least partially around a clip of the catheter interface protection device, and securing a latch of the catheter interface protection device around the clip. A device for positioning a subject in a prone position can include a padded area including an opening configured to accommodate a catheter interface protection device.

Abstract: A balloon catheter has a shaft having a Y-connector provided at the proximal end, and a balloon provided at the distal end, the balloon having a balloon body having opposing first and second ends, and a reinforcement fiber layer wrapped on the balloon body, the fiber layer formed from a single continuous fiber wrapped first radially around the balloon body in non-continuous rows, followed by a figure-8 wrap that continuously traverses from the first end to the second end, and the second end back to the first end.

Abstract: Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology.

Abstract: The present disclosure provides a hydrocephalus shunt including a ventricular catheter portion having an omniphobic surface. The ventricular catheter portion comprising: a proximal end portion and a distal end portion; wherein the proximal end portion is comprised of fluoropolymer tubing and the distal end portion is comprised of tubing that is comprised of a second material selected from the group consisting of a non-fluorinated polymer, non-perfluorinated polymer, silicone elastomer, fluorosilicone elastomer, or perfluorosilicone elastomer.

Abstract: A method for monitoring patients undergoing cSDH evacuation for spreading depolarization comprising the steps of: placing a subdural electrode strip and drain tube having a distal tip on the cortex of the patient, and a method and device wherein, at the time of surgery, a subdural assembly comprising a drainage tube and an electrode strip is placed between the brain and skull of a patient undergoing cSDH evacuation.

Abstract: Disclosed is a system including a flow control assembly. The system may include a flow regulating shunt system, for various purposes. The flow control assembly may be controlled according to selected parameters and methods.

Abstract: An apparatus includes a body assembly, a guide rail, a dilation catheter, and a guide rail actuation assembly. The guide rail extends distally from the body assembly and has a malleable distal portion with a distal end. The dilation catheter is slidably disposed relative to the guide rail. The dilation catheter includes an expandable element configured to dilate a passageway within a head of a patient. The a guide rail actuation assembly is operable to drive longitudinal movement of the guide rail relative to the body assembly between a distal position and a proximal position. The guide rail actuation assembly is configured to maintain the guide rail at a selected one of the distal position or the proximal position.

Abstract: A dilation catheter is slidably disposed relative to a first guide. A second guide is slidably disposed relative to the first guide and relative to the dilation catheter. The second guide includes an indicator element indicating a position of the distal end of the second guide in three-dimensional space. The second guide positions the indicator element at the distal end of the first guide and remains longitudinally stationary as the dilation catheter translates distally from a proximal position to an intermediate longitudinal position. The second guide translates concomitantly with the dilation catheter as the dilation catheter translates distally from the intermediate longitudinal position to a distal position. The indicator element is positioned with the distal end of the dilation catheter as the dilation catheter translates distally from the intermediate longitudinal position to a distal position.

Abstract: An apparatus includes a handle, a guide member extending distally from the handle, and a dilation catheter slidably disposed relative to the guide member. The dilation catheter is operable to translate relative to the handle along a longitudinal range of motion from a proximal-most position to a distal-most position. The dilation catheter includes an expandable element configured to dilate a passageway within the head of a patient and a distal end. The dilation catheter actuator includes a rotary member operable to rotate relative to the handle to thereby drive translation of the dilation catheter along the longitudinal range of motion.

Abstract: A device (1) for the application of liquid medical substances (100) comprises a main body (2) extending around a longitudinal axis (X) and comprising a housing portion (3) at a first open end (4) and a delivery portion (5) at a second open end (6) which is opposite the first (4); a hermetically sealed cartridge reservoir (7) containing a liquid medical substance (100); a perforating element (8) disposed inside the main body (2) in a position falling between the housing portion (3) and the delivery portion (5) and such as to achieve the perforation of one end of the cartridge reservoir (7). The perforating element (8) has a tubular shape and comprises, in a central portion thereof, a cylindrical conduit (12) having a cutting edge (14) faced towards the housing portion (3).

Abstract: The present invention relates to a layered material for mucoadhesion, comprising a modified acrylic polymer and hydroxypropyl methylcellulose, wherein the weight ratio of the modified acrylic polymer: hydroxypropyl methylcellulose is 1:4 to 4:1, and the layered material has a thickness of 0.0001 millimeters to 100 millimeters. The layered material of the present invention has mucoadhesion ability, so it can be prepared into a patch or a needle patch and help the fixation of the patch or the needle patch, and this is advantageous for the controlled-release of drugs. The present invention also relates to a patch comprising the layered material. In addition, the present invention relates to a microneedle patch comprising a needle layer, a base layer and a backing layer, wherein the backing layer comprises the aforementioned layered material and benefits the fixation of the microneedle patch. This microneedle patch is suitable for lesions on mucosa.

Abstract: A microneedle device includes a substrate and multiple microneedles. The substrate has a first surface. The multiple microneedles are arranged on the first surface. Each of the microneedles includes a conical projection and a shell. The conical projection has a base and a first top opposite to each other. The base is adjacent to the first surface. A material of the conical projection includes a conductive gel. The shell has a second top covering the first top. A material of the shell includes at least one soluble polymer. There is a first distance of 3 ?m to 100 ?m between the first top and the second top. The microneedle device has the advantages of good conductivity and good needle tip appearance. A manufacturing method of a microneedle device is further provided.

Abstract: A medical patch may include a flexible substrate and a plurality of water-soluble microneedles extending from a surface of the substrate. The water-soluble microneedles may include polyvinylpyrrolidone (PVP) and calcium peroxide (CPO). Application of the medical patch to a wound causes the PVP to dissolve and the CPO to interact with the water and form hydrogen peroxide and oxygen.

Abstract: Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue.

Abstract: A microneedle system is provided including a needle assembly having a microneedle with a longitudinal body with a diameter of about 50 microns to about 200 microns, the microneedle defining a sharpened tip and a proximal end thereof, the microneedle having first and second lumens extending therethrough, each of the first and second lumens having a distal openings located proximal to the sharpened tip and a proximal opening at a proximal end of the microneedle; a base having a distal end and a proximal end, the distal end of the base coupled to the proximal end of the microneedle and defining first and second passages in fluid communication with the first and second lumens; and a pair of tubes coupled to the base, each tube in fluid communication with a respective first and second passage of the base; a syringe pump; and circulation tubing connecting the syringe pump with the pair of tubes in the needle assembly.

Abstract: A portable, self-sanitizing microneedle device similar in size and shape to a pen, or marker that can be held and manipulated by a human hand. The microneedle device is intended for collagen remodeling in the skin, specifically targeting acne scars and used for anti-aging. The microneedle device having a main body with a handle attached to a circular base support structure, a circular platform structure features a removable and replaceable head, which incorporates all the necessary support structures for the microneedles. This head is designed with a substantially planar substrate that holds multiple microneedles. These microneedles are embedded at their broad base ends within the substrate, with their sharp ends projecting upwards. In the preferred design, the microneedles are arranged in concentric circles on the planar surface of the head. The cap is sealingly and removably attached to the head over the microneedle array using a compression fit.

Abstract: Implantable graft-port systems, devices, and methods for establishing access to a fluid-filled internal body space of a patient including the patient's vascular system for blood treatments are described herein. A port device includes a substantially flat surface. The surface is oriented proximal to and substantially parallel with the patient's skin when the device is subcutaneously implanted. The port device includes a tapered seat disposed in a center of the surface and configured to receive a tip of an access tube. The tapered seat is configured to receive the tip of the access tube therethrough. A lid is configured to couple to the substantially flat surface of the port device and includes a guide configured to engage the tip of the access tube and to facilitate percutaneous introduction of the access tube toward the tapered seat irrespective of an introduction angle. The guide includes a continuous sequence of fluted features.

Abstract: A vascular access port has a single unitary septum, included in an upper wall of the port body. The septum has an arched or curved portion extending at least partially down a side of the port body opposite the outlet port and covering the lateral access zone or straight-line-access aperture to the outlet port/aperture.

Abstract: One or more image capture devices may capture, over a period of time, a plurality of images of an environment. One or more processors may determine, based on the plurality of images, a plurality of locations of a plurality of medical devices and a plurality of types of the plurality of medical devices; determine, based on the plurality of locations, a plurality of distances between the plurality of medical devices; determine, based on the plurality of distances and the plurality of types, at least one event of the following events: (i) a connection of a first medical device to a second medical device and (ii) a disconnection of the first medical device from the second medical device; and update, based on the at least one determined event, a database including current connections between the plurality of medical devices.

Abstract: A connector assembly including a body portion defining a cavity and a luer portion extending in the cavity, a proximal connector disposed at least partially in the cavity of the body portion, a distal connector slidably coupled to the body portion, and a compressible valve member mounted in a cavity of the proximal connector. The distal connector including first and second arms hingedly or pivotably coupled to each other. The valve member may have an internal chamber and a slit extending from a distal end portion of the valve member into the internal chamber. When the distal connector is coupled to a mating connector, the valve member is compressed and the slit is opened such that a fluid path extending from the inlet port through the internal chamber to the outlet port of the luer portion is opened to fluidly communicate the proximal connector with the mating connector.

Abstract: An example of a method of enabling medical fluid transfer between a source container and a destination container can comprise the steps of providing a closed-system fluid transfer module comprising a first closeable, resealable medical connector and a second closeable, resealable medical connector, a multidirectional fluid control valve with a driving interface configured to interface with an electromechanical driver of an electronic medical fluid transfer device, and an intermediate container or an intermediate pumping region; and instructing a user to couple the closed-system fluid transfer module to the electronic medical fluid transfer device.

Abstract: A system for limiting inflation of an expandable member (e.g., a balloon) in an intravascular circulatory support system of a patient may comprise a drive unit and an air mover limiter. The drive unit may include an air mover and a motor. The air mover may have a first end and a second end. The first end may be fixed and have a pneumatic output in fluid connection with the expandable member. The second end may be movable and pneumatically closed. The air mover limiter may be configured to restrict displacement of the second end to under-inflate the expandable member based on the blood pressure of the patient. Displacement of the second end moves a volume of air into or out of the expandable member. The volume of air corresponds to the air mover limiter configuration.

Abstract: Various aspects of the present invention are directed towards apparatuses, systems, and methods that may include a blood pump. The blood pump may include an impeller assembly housing, an impeller assembly having an impeller configured to cause blood to flow through the pump, a motor housing, a motor configured to drive the impeller, and a pivotable housing connector.

Abstract: An example renal support pump includes a renal support device including an outer catheter shaft having a longitudinal axis and a distal end region coupled to a renal pump assembly, wherein the renal pump assembly includes a frame and an impeller assembly, wherein the impeller assembly is disposed within the frame, and wherein the impeller assembly is configured to rotate relative to the frame about the longitudinal axis of the catheter shaft.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that may include a magnetic drive system of a blood pump. The magnetic drive system may include a drive shaft coupled to an impeller, a driven magnet assembly coupled to at least one of the drive shaft and the impeller, and a driving coil assembly configured to drive the driven magnet assembly.

Abstract: An assembly includes a portable centrifugal pump and an electromagnetic motor including a rotor having an axis X and including first main permanent magnets that cooperate with a stator and are arranged in pairs, in particular in fours. The first main permanent magnets are arranged opposite a magnetised part that is capable of bearing the same number of magnets as the number of first permanent magnets and is secured to the pump. The first main permanent magnets create a magnetic flux. The magnetic flux of the rotor interacts with axial protruding poles and radial protruding poles of the stator.

Abstract: A system includes a wearable device including at least four magnets and a plurality of device electrical connectors, wherein first and second portions of the magnets are positioned to respective first and second sides of a wearable device line of symmetry; and an electrode device including a plurality of magnetic elements and a plurality of electrode electrical connectors, wherein first and second portions of the magnetic elements are positioned to respective first and second sides of an electrode device line of symmetry, wherein a first total magnetic force that is to a first side of the wearable device line of symmetry is sufficiently equal to a second total magnetic force that is to a second wearable device line of symmetry, whereby the first total magnetic force and the second total magnetic force cooperate to retain the device electrical connectors in contact with the electrode electrical connectors.

Abstract: An implantable patient-controlled analgesic device includes a microelectrode, a control member, and a connections member. The microelectrode comprises a conductive polymer doped with a dopant, wherein the microelectrode is configured to be implanted within a patient's body. The control member is configured to control the microelectrode via an electrical current. The connection member is coupled to the microelectrode and the control member such that the electrical current can flow from the control member to the microelectrode. In some instances, the implantable patient-controlled analgesic device can be coupled to a surgical drain.

Abstract: Embodiments of the present disclosure pertain to a system for holding at least one peripheral nerve. The system generally includes: a support surface operational for holding the peripheral nerve; a first fastener receptacle positioned on the proximal end of the support surface; and a second fastener receptacle positioned on the distal end of the support surface. Further embodiments of the present disclosure pertain to methods of holding at least one peripheral nerve by utilizing the systems of the present disclosure. Such methods generally include: placing a system of the present disclosure at or near a peripheral nerve; positioning the peripheral nerve on the support surface of the system; and placing at least one fastener on the first fastener receptacle and the second fastener receptacle of the system. The methods of the present disclosure may also include a step of implanting electrodes into or in between fascicles of the peripheral nerve.

Abstract: A novel delivery system for implantation of a cardiac pacing lead comprising an elongated delivery sheath sized to accept the cardiac pacing lead inside thereof and an electrically-active elongated stylet positioned along the cardiac pacing lead and having a first distal electrode configured to provide a first electrical connection to the proximal end of the elongated stylet. The implantation method includes a step of pre-checking a first position in the cardiac tissue by temporarily confirming the ability to deliver the pacing therapy at that position using the first distal electrode of the elongated stylet. If the first position is determined to be acceptable, the cardiac pacing lead is implanted at that position. Otherwise, the delivery system is moved to another position without any significant trauma to the cardiac tissue at the first position.

Abstract: A cardiac pacing lead comprises an elongated flexible body with one or more lead electrodes positioned at a distal end thereof. The lead electrode may be electrically connected to one or more lead connectors at the proximal end, which is configured to transmit electrical signals to or from the distal lead electrode. The elongated flexible body may include a lumen in the center of the lead cross-section. The lumen may be sized to slidingly accept an electrically active elongated stylet positioned therein. The elongated stylet comprises one or more stylet electrodes located at a distal end thereof and electrically connected to one or more stylet connectors at a proximal end thereof. These connectors may be used to transmit electrical signals to or from corresponding distal stylet electrodes. The implantation method includes a step of position pre-checking using the elongated stylet before committing to implantation of the pacing lead.

Abstract: A taste presentation device may have a first electrode and a second electrode provided to allow an electric circuit to be formed between a food or drink to be taken by a user and a body of the user, and an electric stimulus generation unit that supplies a current for generating an electric stimulation between the first electrode and the second electrode, the electric stimulus generation unit includes a noise reduction unit that reduces a noise component in the current.

Abstract: Disclosed herein are devices, systems, and methods for ameliorating or treating or preventing Alzheimer's Disease and related dementias. Methods may include using individual patients' data to identify the optimal treatment target(s) as well as the stimulation intensity, frequency, or waveform, or any combination thereof, for transcranial electromagnetic induction delivered via a device as in the case of Transcranial Magnetic Stimulation. Systems and methods include a platform or infrastructure for treatment delivery and data processing. In some embodiments, methods are applied to restore cognitive function, ameliorate clinical symptoms, modify altered mechanisms of plasticity, modulate cortical excitability and reactivity, or induce changes in local brain metabolism.