Abstract: Catheter-delivered endovascular medical devices are described. The devices may include a pull wire attached to a deployable dual basket system. The deployable dual basket system may include a proximal basket and a distal basket that are connected by basket connector tether memory metal strips that rotate/twist relative to the longitudinal axes of the basket and form flex points of the system. The proximal basket and the distal basket may be comprised of a plurality of cells and the proximal basket may taper at its proximal end and the distal basket may be tapered at its distal end. Methods of using and making the devices are also described.

Abstract: In some examples, a capture assembly configured to remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system, includes a body configured to receive the material of interest. The body can be configured to axially lengthen and shorten.

Abstract: A forceps includes a first jaw member, a second jaw member, a drive rod assembly and a moveable handle attached to a fixed handle. The first jaw member and the second jaw member are in opposing relation relative to one another, and at least one of the first jaw member and the second jaw member is relatively movable from a first open position to a second clamping position when the first jaw member and the second jaw member cooperate to grasp tissue therebetween. Moving the moveable handle relative to the fixed handle moves the drive rod assembly for imparting movement of at least one of the first jaw member and the second jaw member from the first position and the second position. The moveable handle has an actuator with a lost motion connection between the first and second jaw members and the actuator.

Abstract: A surgical instrument includes a handpiece including a housing and a motor disposed in the housing. An end effector assembly is operably coupled to the handpiece. The motor actuates the end effector assembly. A temperature measurement assembly is in the housing. The temperature measurement assembly measures a temperature of the motor. The temperature measurement assembly includes a printed circuit board (PCB) including an orifice extending through the PCB. An infrared (IR) sensor is on the PCB. The IR sensor transmits IR light to a temperature measurement location of the motor through the orifice of the PCB. The IR sensor detects IR light reflected from the temperature measurement location of the motor to determine a temperature of the temperature measurement location of the motor.

Abstract: A surgical instrument includes an ultrasonic transducer, an ultrasonic transmission waveguide extending from the ultrasonic transducer, and an ultrasonic blade acoustically coupled to the ultrasonic transmission waveguide. The ultrasonic blade includes a base and a curved body extending distally from the base. The curved body includes a tissue-treating surface extending on a first side of the curved body and a curved edge extending on a second side of the curved body opposite the first side. The curved edge has a proximal end and a distal end, wherein the proximal end is offset from the distal end in a first direction, wherein the proximal end is offset from the distal end in a second direction, and wherein the first direction is perpendicular to the second direction.

Abstract: A steerable transseptal punch system and method of using the steerable transseptal punch system to access the left atrium.

Abstract: A device, including an insertion tool including an insertion guide that is flexible in a direction lying in at least a plane lying on a longitudinal axis thereof, the insertion guide having a slit and/or a gap extending in the longitudinal direction, the plane extending through the slit and/or gap, wherein the guide configured to maintain a pre-curved electrode assembly in a substantially straight configuration while preventing the electrode assembly from twisting in response to stresses induced by bias forces which urge the assembly to return to its pre-curved configuration, when the insertion guide is flexed in the plane.

Abstract: A device for clearing an obstructed airway of a subject, including an airway interface configured to be positioned over a mouth and/or nose of the subject, a pump in fluid communication with the airway interface and configured to generate suction at the airway interface when activated, and a sleeve surrounding the pump, where the device is configured to activate the pump to generate the suction when the airway interface is pushed against the mouth and/or nose of the subject by pushing on the sleeve, where the device is configured to be held and activated with one hand.

Abstract: A jointed rod assembly for use in a spinal fixation construct involves a caudal rod portion connectable to an adjustment mechanism, and a cranial rod portion connectable to the adjustment mechanism. The adjustment mechanism is configured to rotate the caudal and cranial rod portions relative to one another about a joint axis that is generally perpendicular to the longitudinal axes of the caudal and cranial rod portions. The caudal and cranial rod portions may be dimensioned to be compatible with other pieces of hardware commonly used for spinal fixation, such as bone anchors (e.g., pedicle screws), occipital plates, reducers, and others. The caudal and cranial rod portions are composed of a strong, rigid, non-absorbable, biocompatible material. The jointed rod assembly may be advantageously used in spinal fixation systems and methods of spinal fixation.

Abstract: A method of stabilizing a spine providing a fixation system, the fixation system including, a bone fastener, and a modular assembly attachable to the bone fastener. The modular assembly includes a tulip element and a ring element positioned in the tulip element to restrict motion between the bone fastener and the tulip element to uniplanar motion.

Abstract: The present invention discloses an interspinous process fusion device, a method of fabricating the interspinous process fusion device, and a surgical method for maintaining a space between two spinous processes in a spine of a patient using the fusion device. The interspinous process fusion device including a distal tip member, a middle plate, a proximal plate, an elongate member, and a plurality of movable wings. The elongate member having a first end, a second end, and a longitudinal axis extending between the first and second end. The distal tip member is connected to the first end of the elongate member, the proximal plate is connected to the second end of the elongate member, and the middle plate and plurality of wings are positioned intermediate the distal tip member and the proximal plate along the longitudinal axis to form the interspinous process fusion device assembly.

Abstract: A set for dorsal spinal fusion comprises a detachable handle made of plastic material and a screwdriver that can be coupled to the removable handle without the use of tools. A receptacle of the handle for the screwdriver is made of plastic material. Also, a handle is disclosed, which in particular comprises a ratchet mechanism.

Abstract: An inserter for attaching a modular yoke to a bone screw and for providing an indication of attachment, comprises a tubular body having a central lumen, distal and proximal ends, and an attachment portion for releasable attachment to a yoke having a bottom opening for receipt of a head of said bone screw. The inserter includes an inner shaft having a distal end configured to be received into the yoke, the shaft being axially movable within the lumen from first to second axial positions in response to the introduction of the bone screw head into the yoke bottom opening. An indicator button supported by the body is movable in response to axial movement of the shaft from a first indicator position indicating the first axial position of the shaft relative to the body to a second indicator position indicating the second axial position of the shaft relative to the body.

Abstract: A bone implant system may include a plurality of bone anchors, a superior rod attachable to a superior portion of a bone via the bone anchors, and an inferior rod attachable to an inferior portion of the bone via the bone anchors. The superior rod may have a superior end, and the inferior rod may have an inferior end. The superior rod may telescopically engage the inferior rod such that a cavity is present within at least one of the superior rod and the inferior rod and such that a length of the combined superior and inferior rods, measured between the superior end and the inferior end, is adjustable. The cavity may contain a micropump and a chamber. The micropump may be configured to expel fluid into the chamber to urge the length to increase.

Abstract: Embodiments are directed to fusion implants, insertion instruments, and methods of using the same for implanting one or more fusion implants across a sacroiliac joint and into an ilium and sacrum for fusing the sacroiliac joint. In some cases, fusion-promoting material may be inserted in the fusion implant for further promoting fusion across the sacroiliac joint. In some cases, neurophysiologic monitoring may be performed as the fusion implants are placed across the sacroiliac joint.

Abstract: The present invention provides a medicament delivery device configured for delivery of a medicament through a removable cartridge which includes a cylindrical construct configured for receiving a plunger rod at a proximate end with a central chamber having a side portal and an axial end portal in communication with a distal bone delivery end, the side portal extending from the central chamber and configured for receipt of the removable cartridge, the central chamber having a radially extending sidewall which presents an elliptical body and the axial end portal configured for reciprocal receipt of a telescopic plunger, the distal bone delivery end being in communication with the removeable cartridge for distribution of a medicament therethrough.

Abstract: A medical balloon device includes an outer member extending along an axis. An inflatable member has a proximal end extending from a first end of the outer member and a distal end. An inner member is positioned within the outer member and the inflatable member such that a first end of the inner member is coupled to the distal end of the inflatable member. A support member is movably disposed within the inner member and includes a first end configured to removably engage the first end of the inner member. Translation of the support member along the axis causes the inflatable member to move between a first position in which the inflatable member has a first length and a first profile and a second position in which the inflatable member has a second reduced length and a second reduced profile. Methods of use are disclosed.

Abstract: An instrument for electrosurgical treatment including an instrument head which forms a conveying body with a gas-fillable lumen. The lumen is connected to at least one first opening and at least one second opening in the instrument head. A primary stream of gas leaves through the first opening. The second opening is arranged such that a secondary stream exits the second opening next to the primary stream and/or with additional secondary streams out of additional second openings—away from the instrument head, at least partially peripherally surrounding the primary stream. An electrode is located in the flow of gas exiting out of the first opening for igniting a plasma between the first opening and the tissue to be treated. Due to the secondary stream accompanying the primary stream, an ignition of the plasma is successful even if the instrument is at a relatively large distance from the tissue.

Abstract: Structures for treating tissue with high-frequency energy, methods of making a structure for treating tissue with high-frequency energy, and methods of treating tissue with high-frequency energy. A structure for use in treating tissue may include multiple microblades composed of an electrical conductor. Each of the microblades may include a shaft and a tip arranged adjacent to an end of the shaft. The tip includes multiple surfaces that surround a solid core of the tip and at least two of the surfaces may taper toward the end of the shaft.

Abstract: A device for providing a magnetic treatment by evoking muscle contraction by a time-varying magnetic field and providing a RF treatment by heating biological structure. The device includes an applicator having an RF electrode and a magnetic field generating device. The device may also include a main unit, a human machine interface, and a control unit. The control unit adjusts a signal provided to the RF electrode and creates an RF circuit, and also adjusts the signal provided to the magnetic field generating device and creates a magnetic circuit electrically insulated from the RF circuit. The RF circuit may include a power source and a power amplifier, and the magnetic circuit may include an energy storage to supply the magnetic field generating device with electric current.

Abstract: Disclosed is a multifunctional medical device, apparatus or system that is capable of performing a surgical procedure or operation and also capable of removing or reducing smoke particles generated by the surgical procedure or operation on a subject, the apparatus comprising a plurality of electrodes, two of which are configured to be in electrical communication with or being electrically connectable to opposite poles of a source of high voltage dc electricity to ionize, and remove or reduce smoke particles, and at least one of which is also configured to be part of a RF circuit to perform a surgical procedure or operation such as tissue cutting, cauterization, tissue sealing or coagulating at a surgical site on the subject. Also disclosed is a method of employing the above disclosed device, apparatus or system or variations thereof to perform a surgical procedure or operation at a surgical site and to remove or reduce smoke particles generated during the surgical procedure or operation.

Abstract: An electrosurgical instrument includes an end effector assembly including first and second jaw members. At least one of the first or second jaw members is movable about a pivot relative to the other from a spaced-apart position to an approximated position to grasp tissue between first and second opposed surfaces of the first and second jaw members, respectively. The electrosurgical instrument further includes an interface configured to provide a feedback related to a size of tissue grasped by the first and second jaw members. At least one of the first or second jaw members includes a touch sensor configured to sense a touch span where the tissue touches the at least one of the first or second opposed surfaces. The end effector assembly further includes an angle sensor configured to sense an angle ? about the pivot between the first and second opposed surfaces.

Abstract: Methods and devices described herein facilitate improved treatment of body organs.

Abstract: A device for dividing a fibrous structure comprising an expandable member positioned near the distal end of a catheter and in fluid communication with the lumen of the catheter so that the expandable member can be biased between an inflated state and a deflated state to tension the fibrous structure, and electrosurgical elements situated on or proximate to an outer surface of the expandable member and configured to deliver electrical and thermal energy to the tensioned fibrous structure in a manner that results in division of the tensioned fibrous structure. A method for dividing a fibrous structure comprising positioning proximate the fibrous structure an expandable member having electrosurgical elements, expanding the expandable member outwards to tension the fibrous structure across the electrosurgical elements, and activating the electrosurgical elements to deliver energy to the tensioned fibrous structure to divide the tensioned fibrous structure.

Abstract: The present disclosure provides catheters for electroporation systems. One catheter includes a plurality of catheter electrodes disposed along a portion of a distal end of the electroporation catheter. The plurality of catheter electrodes includes a plurality of first type catheter electrodes adapted for use with an electroporation generator during an electroporation procedure and a plurality of second type catheter electrodes adapted for use with an electroporation generator during an electroporation procedure and for use with a diagnostic subsystem. The plurality of first type catheter electrodes is positioned at a distal end of the electroporation catheter. Each second type catheter electrode is adjacent another second type catheter electrode.

Abstract: A model eye is disposed on a reference light path of reference light in a reference optical system so as to reflect or scatter the reference light at a model retina in order to form an interference optical system used to obtain interference light from the reference light of the reference optical system and signal light illuminated onto an examined eye in a signal optical system.

Abstract: Systems, devices, and methods are described for assessing the risk of developmental, cognitive, social, or mental abilities or disabilities in very young patients (e.g., in the first 2-6 months of life). Generally, the decline in visual fixation of a subject over time with respect to certain dynamic stimuli provides a marker of possible abilities or disabilities (such as ASD). The visual fixation of the subject is identified, monitored, and tracked over time through repeated eye tracking sessions, and data relating to the visual fixation is then analyzed to determine a possible increased risk certain conditions in the subject. A change in visual fixation as compared to similar visual fixation data of typically-developing subjects or to a subject's own, prior visual fixation data provides an indication of a developmental, cognitive, or mental ability or disability.

Abstract: The present disclosure provides a glaucoma image recognition method, device and diagnosis system. The method includes acquiring a fundus image; obtaining an optic disc image and an optic cup image according to the fundus image; obtaining a disc rim image according to the optic disc image and the optic cup image; and determining whether the fundus image is classified as glaucoma according to the disc rim image.

Abstract: An optical imaging system includes a first lens system housed in a body of a mobile telecommunication device, the first lens system having a first optical axis, a first entrance pupil fixed in space in a reference plane associated with said body, and a first focal length; and an optical telescope providing a diffraction-limited imaging within a spectral range from at least 486 nm to at least 656 nm. The optical imaging system is configured to image, when the optical telescope is inserted between the first lens system and an entrance pupil of a visual system of an eye (EPE), the EPE onto the first entrance pupil and vice versa with a substantially unit magnification.

Abstract: The invention relates to a therapy planning device for planning a therapy to be applied to tissue of a subject (2). A tissue parameter distribution, which has been generated based on a magnetic resonance fingerprint scan of the tissue, and a therapy goal distribution, which defines a distribution of at least one parameter being indicative of a desired effect of the therapy, are provided. A machine learning module (13), which has been trained to output at least one therapy application parameter defining the application of the therapy based on an input tissue parameter distribution and an input therapy goal distribution, is used for planning the therapy by determining the at least one therapy application parameter based on the provided tissue parameter distribution and the provided therapy goal distribution. This allows for a consideration of the actual quantitative tissue parameter distribution of the patient, thereby improving planning quality.

Abstract: A method for utilizing robotic surgical data for providing surgical training is disclosed. The method includes collecting, by a computing device, data related to a surgical procedure from one or more components of a computer-assisted surgical system. At least one of the one or more components is a robotically controlled surgical device. A graphical depiction representative of the surgical procedure is generated based on the collected data from the one or more components of the computer-assisted surgical system and one or more images providing a visual depiction of a patient's anatomy. A graphical user interface is output to a display device. The graphical user interface includes the graphical depiction of the surgical procedure and the collected data from the one or more components of the computer-assisted surgical system, to provide surgical training.

Abstract: A system includes a display and a processor. The processor is configured to compute multiple forecasted local activation times (LATs) at different respective locations on cardiac tissue of a subject, by simulating a propagation of a physiological activation potential along the cardiac tissue with a particular portion of the cardiac tissue, which is currently conductive, being non-conductive. The processor is further configured to generate, based on the forecasted LATs, a forecasted electroanatomical map representing a forecasted state of the cardiac tissue following an ablation of the particular portion of the cardiac tissue, and to display the forecasted electroanatomical map on the display. Other embodiments are also described.

Abstract: A method for generating an intraoperative 3D brain model while a patient is operated. Before an opening in a patient's skull is made, the method includes: providing a preoperative 3D brain model of a patient's brain and converting it to a preoperative 3D brain point cloud; providing a preoperative 3D face model of a patient's face and converting it to a preoperative 3D face point cloud. After the opening in the patient's skull is made, the method includes: matching the intraoperative 3D face point cloud with the preoperative 3D face point cloud to find a face point transformation; transforming the intraoperative 3D brain point cloud based on said face point cloud transformation; comparing the intraoperative 3D brain point cloud with the preoperative 3D brain point cloud to determine a brain shift; and converting the preoperative 3D brain model to generate an intraoperative 3D brain model based on said brain shift.

Abstract: Systems and methods for planning delivery of an object via a catheter, such as transseptal delivery of a prosthetic mitral valve to a patient's heart are disclosed.

Abstract: A robot-assisted endoscope system and control methods thereof allow a user to perform intraluminal interventional procedures using a steerable sheath. A processor generates a ghost image based on a non-real-time insertion trajectory of the sheath, and a real-time image based on a real-time insertion trajectory for inserting an interventional tool through the sheath towards the target site. A display screen outputs navigation guidance data for informing a user how to manipulate the distal section of the sheath towards the target site such that the real-time image overlaps or coincides with at least part the ghost image and the real-time insertion trajectory becomes aligned with the non-real-time insertion trajectory.

Abstract: Systems and methods for generating multiple registrations is provided. An image depicting a portion of a patient's anatomy and a tracking device affixed to an accurate robot may be received. A first registration of a patient coordinate space to a robotic coordinate space may be generated based on the image. A second registration of the patient coordinate space to a navigation coordinate space based at least in part on a position of second markers on the tracking device detected by a navigation system may be generated. The first registration and the second registration may be independent of each other.

Abstract: A system and method for performing an automated medical procedure is provided. The method may include positioning an effector unit over a patient, acquiring medical imagery of the patient, analyzing the medical imagery using at least one processor to determine a location, and positioning a subunit of the effector unit to perform the automated medical procedure at the location. The automated medical procedure may be performed using at least one of a plurality of subunits of the effector unit. The automated medical procedure may be a body fluid aspiration procedure and one of the plurality of subunits of the effector unit may include a fluid aspirating cannula. Multiple subunits may be sequentially used to perform the procedure.

Abstract: The invention relates to an arrangement 10 with an OCT device 20 for scanning an object region volume 22 arranged in an object region 18 with an OCT scanning beam 21, comprising an item 24 which has a section 84 that is arrangeable in the object region 18 and is localizable in the object region volume 22 by means of the OCT device 20, and having a computing unit 60 connected to the OCT device 20 and having a computer program for determining a 3-D reconstruction of the object region volume 22 and determining the location of the portion of the object 24 in the object region volume 22 by processing OCT scan information obtained with the OCT device 20 by scanning the object region volume 22. According to the invention, the computer program has a calculation routine for determining a target area in the 3-D reconstruction of the object region volume 22, which routine determines a reference variable for the object 24 for the target area.

Abstract: The present disclosure provides a system and method for controlling an articulating member including a tool. The method includes determining a first confidence indicator based on a manual control mode for the articulating member, determining a second confidence indicator based on an autonomous control mode for the articulating member, generating an allocation function based on the first confidence indicator and the second confidence indicator, and generating a control command for the articulating member based on the allocation function.

Abstract: A robotic electromechanical surgical instrument includes a housing, an elongated shaft that extends distally from the housing, a wrist assembly supported on the elongated shaft, an end effector coupled to the wrist assembly, cables coupled to the wrist assembly, and an electrical cable coupled to the end effector. The wrist assembly includes a first joint coupled to a second joint. The first joint includes a proximal segment defining an arcuate surface and a distal segment defining an arcuate surface. The electrical cable is positioned relative to the proximal arcuate surface and the distal arcuate surface such that during articulation of the wrist assembly the electrical cable rolls off of the distal arcuate surface as the electrical cable rolls on to the proximal arcuate surface and the electrical cable rolls off of the proximal arcuate surface as the electrical cable rolls on to the distal arcuate surface.

Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various modular medical devices for in vivo medical procedures.

Abstract: A system includes an input control, an instrument, a memory storing instructions, and one or more processors coupled to the memory. A first axis of a first coordinate frame is defined along a length of the input control and is associated with an orientation of the input control. A second axis of a second coordinate frame is defined along a length of the instrument and is associated with an orientation of the instrument. When executing the instructions, the one or more processors perform steps including, while in a following state, receiving a first command corresponding to a rotation of the input control about the first axis, in response to the first command, generating a second command to rotate the instrument around the second axis without rotating the instrument around any axis orthogonal to the second axis, and controlling movement of the instrument according to the second command.

Abstract: The disclosure discloses a universal robot for interventional angiographic surgery and interventional therapeutic surgery. The robot meets the needs of both angiographic surgery and therapeutic surgery, which facilitates the clinical use. The robot is universal for both angiographic surgery and interventional therapeutic surgery, with advantages of simple structure, good stability, modular structure design, and so on, which is suitable for operation environment. By measuring the push and pull force of the micro force sensor at the driving end, the change of the axial friction force of the guide wire is judged, which gives the doctor timely reminder and protects the safety of patients. According to the feedback value of the high precision load cell at the driven end, the clamping degree of the guide wire is adjusted at any time to ensure there is no slipping phenomenon, which meets the needs of vascular interventional surgery.

Abstract: The exemplified system and method facilitate an objective, non-invasive measurement of myelin quality and integrity in living brains based on isolation of myelin-specific magnetic relaxation constants in k-space. The system uses magnetic resonance (MR) signals to select signatures specific to, or associated with, myelin and its structure and to then encode the selected signatures into an image or model to which the quantitative myelin health information can be co-registered with 2D, 3D visualization, and tractography of the myelin-signal isolated MR information. The system also sets a model for digital hierarchical learning of biomedical signals in MR, and beyond, based on experimental data in which it executes the herein described signal isolation operations.

Abstract: Methods and systems for imaging removable dental appliances. Image data taken while a removable dental appliance was worn on a patient's teeth may be used to identify one or more locations of undesirable contact between the removable dental appliance and the patient's teeth and/or one or more attachments on the patient's teeth. The one or more locations of undesirable contact can correlate with undesirable tooth movement compared to expected tooth movement according to a treatment plan. A three-dimensional (3D) model of the removable dental appliance and the patient's teeth may be displayed on a user interface, with the identified one or more locations of undesirable contact highlighted in the 3D model. An alert of the identified one or more locations of undesirable contact may be emitted via the user interface.

Abstract: Systemic lupus erythematosus (SLE) can be diagnosed by affixing a plurality of light sources and a plurality of light detectors against the subject's body near a joint, and sequentially transmitting light from each of the plurality of light sources into the subject's body. Signals are acquired from each of the plurality of light detectors. The rise time of the acquired signals that occurs in response to an inflation of a pressure cuff is determined, and an indication of whether the joint is affected by SLE is made based on the determined rise time. In some embodiments, a plateau time of the acquired signals is also acquired, and the indication of whether the joint is affected by SLE is made based on the determined rise time and the determined plateau time.

Abstract: Data about concentration of one or more types of molecules present within a human body are determined noninvasively using radio frequency (RF) signals. Signals at several different frequencies at very low power levels are emitted using an antenna mounted to a wearable device. Operating values, such as changes to the impedance of the antenna resulting from interaction between the RF signals and the user, are associated with the concentration of one or more types of molecules within the user. These changes in impedance may be relatively small. Circuitry in the device determines internal impedance of the circuitry, compensating for internal impedances and improving overall accuracy of the measured impedance resulting from interaction with the user.

Abstract: The present disclosure provides computer-implemented methods, systems, and devices for improved skin temperature monitoring. Accurate estimates of skin and ambient temperature are generated based on determinations and comparisons of skin and internal device temperature sensor measurements contained on or within example devices. The estimates of skin and ambient temperature measurements facilitate monitoring skin and core temperature changes, detecting physiological events of a wearer of example devices, and determining when skin temperature changes are environmentally or physiologically induced.

Abstract: The present invention is directed to systems and methods for identifying a cardiovascular disease of a patient. In one embodiment, the method includes obtaining measurements for a diastolic pressure, a systolic pressure, a heartbeat period, a stroke volume, and an ejection period for the patient, and then determining an aortic compliance for the patient based on these measurements. The diastolic pressure, systolic pressure, and heartbeat period are each measured directly from the patient, and the stroke volume and ejection period are each measured from echocardiogram data. In another embodiment, the method includes obtaining measurements for a diastolic pressure and a systolic pressure for the patient, obtaining an estimate of a stroke volume for the patient, and then determining an aortic compliance for the patient based on the diastolic pressure, the systolic pressure, and the stroke volume.

Abstract: An apparatus for estimating a core body temperature of an object is provided. According to one embodiment, the apparatus includes a plurality of sensors configured to obtain data from an object and a processor configured to obtain a surface temperature, a heat flux, a skin blood flow rate, and a blood flow velocity by using the data obtained from the plurality of sensors, obtain a skin thermal conductivity based on the skin blood flow rate, and estimate a core body temperature of the object based on the surface temperature, the heat flux, the skin thermal conductivity, and the blood flow velocity of the object.