Abstract: Embodiments provide an adjustable cage template for determining a cage for use in a spinal surgery. The adjustable cage template may include top and bottom cage template, control supports. A configuration of the cage template may be modified and sensors may measure forces applied to the cage template during the modification of the cage template configuration. Modifications to the cage template include rotation of the top cage template relative to the bottom cage template, vertical translation of the top cage template relative to the bottom cage template, or both rotation and vertical translation of the top and bottom cage templates. Information associated with measurements from the sensors may be output to determine whether a current configuration of the cage template is optimal and a final cage template may be selected for the spinal surgery based at least in part on the output information.

Abstract: An acetabular liner having a closed first end, an open second end, and a liner wall having a distal peripheral edge. The acetabular liner wall can include an interior surface, an exterior surface configured to be received within an acetabular shell, a first cutout through the liner wall, a second cutout parallel to the first cutout and through the liner wall, and a third cutout in the interior surface partially through the liner wall, the third cutout extending between the first and second cutouts, and at least one movable tab extending from the peripheral edge inwardly towards an axial center of the liner and having sidewalls defined by one of the sets of cutouts, the tab comprising at least one projection on an exterior surface of the tab configured to removably secure to a portion of an acetabular shell.

Abstract: A branch vessel stent including a stent body and a first developing member, where the first developing member includes a first developing portion and a second developing portion. A length of the first developing portion and a length of the second developing portion in an axial direction of the stent body are both not less than 0.5 mm. A distance between the intersections of the first developing portion and the second developing portion on a plane perpendicular to the axial direction of the stent body gradually increases from a position where the distance is the minimum distance to an end that is away from a first end of the first developing portion or the second developing portion. The minimum distance between the intersections of the first developing portion and the second developing portion on a plane perpendicular to the axial direction of the stent body is less than 2 mm.

Abstract: The invention relates to medical devices and methods of using them. The devices are prostheses which can be percutaneously deliverable with (or on) an endovascular catheter or via other surgical or other techniques and then expanded. The prostheses are configured to have a lattice resistant to dilation and creep, which is defined by a plurality of openings. The prosthesis may also optionally have a stent disposed proximal to the lattice. In exemplary embodiments, the fluoropolymer is expanded polytetrafluoroethylene. The composite materials exhibit high elongation while substantially retaining the strength properties of the fluoropolymer membrane. In at least one embodiment, the lattice is made of a composite material that includes a least one fluoropolymer membrane including serpentine fibrils and an elastomer. A lattice including a generally tubular member formed of a composite material including a least one fluoropolymer membrane containing serpentine fibrils and an elastomer is also provided.

Abstract: An orthopedic walker or walking boot has a body formed from at least one polymeric material. The body defines an upper receiving section, a lower receiving section, and a footbed. The upper receiving section includes first and second portions divided by a median plane of the orthopedic walker, and are arranged to individually articulate about or from the median plane to expand or retract a variable distance between the first and second portions of the upper receiving section along one of anterior or posterior sides of the body. The body may consist of the upper receiving section, the lower receiving section, and the footbed as a continuous structure formed unitarily from the expanded thermoplastic.

Abstract: A boot-type orthopedic or sports footwear usable for controlled walking with stiffening for the lower extremities of legs, comprises: a sole provided with a substantially vertical rear positioning element; a first pair of rear half-hulls, each of which is hinged onto the sole and which cover, when in the closed position, an ankle and part of the lower portion of a leg, i.e. the calcaneal-tibial-tarsal zone, of an individual who is wearing the footwear; a second pair of front half-hulls, each of which is hinged onto the sole and which cover, when in the closed position, at least an upper part of a foot of the individual who is wearing the footwear.

Abstract: An adjustable over corrective therapeutic scoliosis brace configured to facilitate the correction of spinal curvature during a treatment period of a patient is provided. In some embodiments, the scoliosis brace comprises an external shell and one or more periodically adjustable modular internal pads systems. The one or more internal pad systems can be selectively moved and fixedly positioned in a plurality of positions along at least one of the lateral direction or the vertical direction within the external shell, wherein the plurality of positions are designed for periodic adjustment of the corrective force on the spinal curvature during the treatment period.

Abstract: An apparatus and associated methods relate to an external catheter configured with a urine collection bag having a semi-rigid and flexible internal tube adapted to permit fluid engagement with urine streaming from a patient, in a manner that does not require precisely locating a patient's buried, retracted or retractive penis supported by secure connection to the patient coincident to the outer circumference of the internal tube with an adhesive having a removable non-adhesive backing to prevent the dislodging or misplacement of the external catheter or obstruction of the flow of urine and the secure attachment of the tube to a transparent urine collection bag permitting visualization of the inner contents of the bag.

Abstract: A reusable penile attachment for urinary incontinence which uses pressure differential as means of attachment, a cup having a depth having an opening having a first width and an exit having a second width, wherein the first width is greater than the second width; and, wherein the opening of the cup is configured to fit onto a glans of a penis. The exit is fluidly connected to a connector which includes an integrated square angle elbow which positions the connector into a generally horizontal configuration. The connector then connects to a tube having a first end and a second end, wherein the first end is attached to the connector; a collection bag having attachment straps, wherein the collection bag is attached to the second end of the tube; the collection bag is configured to collect urine leakage.

Abstract: An intrauterine device for preventing egg fertilization having a membrane, a frame having a first arm and a second arm, the first and second arms movable from a first position to a second more expanded position. The frame supports the membrane to move the membrane between a first position to a second more expanded position, wherein the first and second arms are non-planar and each arm has a proximal portion, an intermediate portion and a distal portion, The first arm has a bend at the intermediate portion so that the intermediate portion of the first arm lies in a different plane than the proximal portion of the first arm and the second arm has a bend at the intermediate portion so the intermediate portion of the second arm lies in a different plane than the proximal portion of the second arm. An elongated tail portion extends proximally of the membrane. The membrane can have a convex distal portion.

Abstract: A therapeutic device such as an eye mask or compress for delivery of moist heat therapy to a body part such as an eye of a human or animal subject. Example devices are configured to be worn with one or more eye coverage portions positioned over the subject's eye(s). The eye coverage portions have a front side configured for placement against the treated body part, and a back side opposite the front side. The eye coverage portions include recesses or retracted sections configured to be positioned over the wearer's cornea area. The shell of the eye coverage portions may further incorporate antimicrobial properties.

Abstract: A cosmetic pad, having a top layer constructed of non-woven material, a bottom layer constructed in a manner to allow for ventilation through the bottom layer, and at least one heating element between the top layer and the bottom layer and methods for using the cosmetic pad and cosmetic agents therein are provided. A system for applying a cosmetic agent to a subject's skin, hair, hands, feet or face is also provided.

Abstract: Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

Abstract: A chamber has an elongated rectangular flexible panel with a first longitudinal side and a second longitudinal side, a first lateral panel having a substantially triangular shape and rounded corners, and a second lateral panel having a triangular rectangular shape and rounded corners. The first lateral panel is sealingly engaged to the first longitudinal side of the elongated rectangular flexible panel. The second lateral panel sealingly engaged to the second longitudinal side of the elongated rectangular flexible panel. The elongated rectangular flexible panel, first lateral panel, and second lateral panel form the chamber having a substantially triangular prism shape.

Abstract: A frame is carried upon wheels and also includes separate legs, with the wheels and legs movable vertically relative to each other so that the cart can rest upon the wheels or upon the legs. The cart includes multiple compartments, at least some of which feature secure access locks to limit access to authorized individuals. The compartments can be for storage or general items or for items which require a particular environment to be maintained. A display, preferably as part of a tablet, provides a video display for a user and also preferably provides at least one interface for controlling compartments, accessories and movement of the cart. Accessories can include medical functional equipment and aesthetic environment augmenting equipment. A power supply including a rechargeable battery is included with the cart, which in one embodiment can power the wheels for movement of the cart, such as between preset use locations.

Abstract: A wheelchair includes a seat, a first adjustable leg coupled to a first side of the seat, a second adjustable leg coupled to a second side of the seat, one or more turning sensors, and a control unit. The first adjustable leg includes a first leg actuator configured to extend and retract the first adjustable leg. The second adjustable leg includes a second leg actuator configured to extend and retract the second adjustable leg. The one or more turning sensors are configured to output a turning signal indicative of the wheelchair performing a turning motion. The control unit is operable to determine the wheelchair is performing the turning motion based on the turning signal, and automatically adjust a tilt angle of the seat with the first leg actuator and the second leg actuator to lean a user of the wheelchair into the turning motion.

Abstract: The present invention provides an assembly having a collapsible wheelchair and an anti-rollback assembly to brake rotational movement of the wheelchair when a user is unseated, while simultaneously maintaining the ability of the wheelchair to collapse into a storage configuration. The anti-rollback assembly may include a brake bar pivotable between a lock state and an unlock state, a biasing member engaging the brake bar to exert a biasing force to move the brake bar into the lock state, and an actuator configured to engage a seat surface of the wheelchair to move the brake bar into the unlock state when the individual occupies the seat surface.

Abstract: A patient support apparatus for removably retaining differently-sized portable electronic devices. The patient support apparatus comprises a base, a litter with a patient support deck for supporting the patient, and a side rail. The side rail is coupled to the litter and arranged for movement relative to the base. The side rail includes a caddy comprising a back, a first brace, and a second brace spaced from the first brace. The first brace extends laterally from the back and defines a first bottom support region. The second brace extends laterally from the back and defines a second bottom support region converging toward the first bottom support region to arrange the first and second bottom support regions to provide differing points of contact for retaining differently-sized portable electronic devices.

Abstract: A knee replacement therapy unit comprising a base board configured to be attached with a chair; a winch having a crank, the winch attached to the base board and configured to wind a cable thereon; and a feed mechanism attached to the base board and configured to receive a cable therethrough from the winch.

Abstract: An exoskeleton robot for hand and wrist kinetic rehabilitation provides passive, active-assisted, and active resistance rehabilitation for fingers and wrist joints independently. It relieves pain during exercises and stimulates the mechanoreceptors for all hand and wrist joints. The device provides levels of differentiation for finger rehabilitation through independent motion control mechanisms for all ten phalanges of the fingers and the wrist with a full range of motion, which helps in focusing the work on each joint selectively. It is portable, operates using an electric power source only, easy to wear, fits different hand sizes, and most of its parts made of lightweight plastic.

Abstract: The present invention is a hand-held, battery operated facial massager. The facial massager includes a palm-sized base unit and one or more interchangeable heads. Each interchangeable head is designed to attach to the base unit, and is designed to provide a specific type of motion. The facial massager is adjustable for different facial areas and locations on a user's face and neck. The facial massager of the present invention can be manufactured and sold as a kit having one base unit, several interchangeable heads and a battery charger. The simple and compact design of the facial massager allows a user to perform a complete facial massage in the comfort of their home, instead of having to rely on costly and time-consuming professional appointments at a salon.

Abstract: A volute shell-type massage structure and a volute shell-type massager are disclosed. The volute shell-type massage structure includes a wand-type massage body; a volute shell massage body having a volute shell nose and a volute shell body; the volute shell nose is connected to the volute shell body to form a wrapping angle sector S, the volute shell nose in a wrapping angle sector S1 is continuously connected with the volute shell body, and the volute shell nose in a wrapping angle sector S2 is separated from the volute shell body; and the volute shell nose is connected to the wand-type massage body to form a connecting angle b1. When the volute shell body receives acting force from an outer surface of a hole-shaped part to be massaged, the volute shell nose can exert retraction force on the volute shell body, such that strong uninterrupted massage stimulation effects are achieved.

Abstract: An assistive device for stair-climbing assistance includes a powered rail-sliding platform that assists its user through a unique human interface. The device provides powered assistance (a gentle pulling force) and protection (through a safety belt) to help users climb or descend stairs.

Abstract: An exoskeleton system includes a body interface and connects to a power supply. The body interface and the power supply include a quick lock connection mechanism arranged to adjust to the height and width of a user. The body interface includes a connection frame that defines at least two anchoring slots at different heights for connecting to corresponding anchors extending from the power supply. The power supply includes a removable locking element for securing the anchors to the anchoring slots at a selected height position. The power supply may have transmission arms driven by a drive system, and an assistive system for connection to a user. The transmission arms may be slidably connected to the drive system and have a locking part to secure the power supply in a plurality of predetermined width positions.

Abstract: A smart walking assistance device with a walker frame having generally vertical sides and an intersecting front. Wheels located at both ends of a bottom edge of the sides. A soft robotic sensing handle extends in a C shape along the upper edges of the sides and front. The sensing handle has multiple contiguous air filled chambers, each containing a pressure sensor for producing a pressure signal representing the pressure within the chamber. A microcontroller unit receives the pressure signals from the pressure sensors of the handle chambers and determines the status of at least one of the device and a user of the device based on the pressure signals. A stabilization mechanism is driven by the microcontroller so as to stabilize the walker in response to the determined status of at least one of the walker and the user.

Abstract: A mechanical chest compression device is secured to a gurney, transport stretcher or ambulance cot while engaging a patient's thorax to provide mechanical CPR during transport. The mechanical chest compression device compresses the patient's thorax against the gurney deck. The mechanical chest compression device may engage the side rails on the gurney, the gurney deck or any suitable structural elements of the gurney.

Abstract: Various apparatus and methods for providing emergency washing including means for discouraging tampering of the various valves.

Abstract: Smart pill bottle caps are provided. In general, a smart pill bottle cap can include a housing. The housing can include a sensor that is configured to monitor one or more characteristics of a pill bottle to which the housing is attached and can include a communication mechanism configured to communicate the one or more characteristics of the pill bottle to an external device. The communicated characteristic(s) of the pill bottle can be used to track usage of pills in the pill bottle, such as a date and time of when a pill was taken and/or a number of pills remaining in the pill bottle. A smart pill bottle cap can also be configured to engage a secondary, standard pill bottle cap that is used with a standard pill bottle.

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a homopolymer comprising a hydrophilic repeating unit or of a copolymer comprising at least one hydrophilic repeating unit and at least one hydrophobic repeating unit. The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The homopolymers have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

Abstract: A device is disclosed that secures a capsule and accommodates puncturing of the capsule and extraction of a medication. The device includes a cavity that receives and secures the capsule. The device includes at least one opening that provides access to the cavity for extraction of the capsule contents.

Abstract: An item storage apparatus includes a first storage to store items, a carrier to take an item from the first storage and convey the item, a first support supporting the carrier to be movable back and forth in a first horizontal direction, a second support supporting the first support to be movable back and forth in a second horizontal direction perpendicular to the first horizontal direction, a vertical moving mechanism supporting the second support to be movable back and forth in a vertical direction perpendicular to the first horizontal direction and the second horizontal direction, and a second storage to store the item. At least one of the first or second storage has a multi-tier structure in which a space for movement of the carrier is between tiers. The first support has a cantilever structure in which one end is secured to the second support and another end is free.

Abstract: The medication dispensing assembly includes a housing having an interior. A medication bottle is disposed in the interior with its cap assembly facing vertically downwardly. The cap assembly includes outer, middle, and inner pieces. The outer and inner pieces are fixed with one another, and the middle piece is fixed with the bottle. A drive unit is disposed in the interior of the housing and is configured to rotate the bottle and the middle piece of the cap assembly about a vertical axis. The three pieces of the cap assembly have respective medication openings, and rotating the bottle causes individual pills to travel first from the bottle into the inner piece, then into the middle piece, then around the vertical axis, and then outside of the cap assembly through the medication opening of the outer piece.

Abstract: The present invention relates to a topical pharmaceutical composition in the form of an aqueous gel comprising at least amitriptyline and/or a pharmaceutically acceptable salt thereof with a content between 10 and 30% by weight relative to the total weight of the composition, and water.

Abstract: The present invention provides a ready to use stable aqueous dosage form of norepinephrine comprising an aqueous solution of norepinephrine or its pharmaceutically acceptable salt, one or more sulfite antioxidants and an ion chelator. The present invention also provides an infusion container filled with an aqueous solution of norepinephrine or its pharmaceutically acceptable salt, wherein the said solution is stable for a prolonged period of time and can be terminally sterilized by autoclaving.

Abstract: Pharmaceutical compositions of (E)-2,4,6-trimethoxy styryl-3-[(carboxymethyl)amino]-4-methoxybenzylsulphone and pharmaceutically acceptable salts thereof are described as well as methods of their use, and a dose regimen of (E)-2,4,6-trimethoxystyryl-3-[(carboxymethyl)amino]-4-methoxybenzylsulphone, sodium salt to reduce the incidence of urothelial toxicity.

Abstract: An object of the present invention is to provide a novel composition for promoting ketone body production. The present invention provides a composition for use in promoting ketone body production, comprising one or more amino acid(s) selected from the group consisting of citrulline, leucine, cysteine, taurine, glutamine, and aspartic acid. The composition according to the present invention may further comprise either or both of a medium-chain fatty acid and a medium-chain fatty acid ester.

Abstract: A pharmaceutical gel composition for intra-intestinal administration comprises (i) a dopamine replacement agent, (ii) a dopamine decarboxylase inhibitor (DDI), and (iii) a COMT inhibitor.

Abstract: The present disclosure relates to utilizing the N6-methyllysine for reducing fat percentage in an organ or tissue or for treating obesity, obesity-related diseases or cancers. More specifically, the present invention relates to the method using N?-Methyl-L-lysine or N?-Methyl-L-lysine producing bacteria or N?-Methyl-L-lysine/l-lysine mixture or N?-Methyl-L-lysine/probiotics mixture to treat obesity, obesity-related diseases or cancers.

Abstract: Some aspects of the invention provide for a method of treating hepatic disorders, lipidemias and cardiac-related risk factors using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.

Abstract: A pharmaceutical composition contains chlorogenic acid and coumaroyl quinic acid. The combined use of chlorogenic acid and coumaroyl quinic acid at a certain ratio can generate a synergistic enhancing effect to effectively inhibit the growth of human kidney cancer cell strain A479, rat kidney cell strain RuCa, and rat transplanted tumor RuCa, providing a novel choice for clinical treatment of kidney cancer and having good market application prospects.

Abstract: The present invention relates to medicaments for use in the prophylaxis or treatment of vasoconstriction related disorders or conditions. Specifically, the present invention relates to (2R) enantiomeric form of a 6-chromanol derivative for use in the prophylactic or treatment of vasoconstriction related disorders or conditions. A preferred 6-chromanol derivative is (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone; N-(benzyl)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamide; N-(phenyl)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamide; methyl 4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)benzoate; (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(morpholino)methanone, and pharmaceutically acceptable salts thereof.

Abstract: A method of treating cancer in a subject includes administering an active agent selected from ascorbic acid, an ascorbic acid derivative, and/or a pharmaceutically acceptable salt thereof and administering a pentaaza macrocyclic ring complex corresponding to formula (I) below:

Abstract: The present invention relates to cyclobenzaprine analogs and amitriptyline analogs, including deuterated forms useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.

Abstract: Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.

Abstract: Provided are methods of treatment of a sphingosine 1-phosphate subtype 1 (S1P1) receptor-associated disorder comprising prescribing and/or administering to an individual in need thereof a standard dose of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl) benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1), or a pharmaceutically acceptable salt, hydrate, or solvate thereof.

Abstract: A method of therapeutic treatment of a tumor pathology including melanoma, tumors of the gastrointestinal tract, and/or thyroid carcinoma by administering to a subject in need thereof melanocortin receptor-4 (MC4R) antagonists is provided. The melanocortin receptor-4 antagonists are suitable in a targeted anti-tumor treatment, and particularly in an adjuvant therapy or in a therapy affecting onset and/or progression of tumor metastasis. A pharmaceutical composition including a melanocortin receptor-4 (MC4R) antagonist in a pharmaceutically acceptable vehicle, and in combination with optional adjuvants, stabilizers and/or preservatives, is also provided.

Abstract: The present invention provides stable, pharmaceutically acceptable and ophthalmologically suitable compositions comprising therapeutically effective amounts of both a pilocarpine compound and a brimonidine compound for treating an ocular condition, the compositions comprising a low amount of sodium chloride present in a limited ratio with the active pharmaceutical ingredient(s). In certain embodiments, provided compositions are free of both a borate buffer and a citrate buffer. Compositions provided by the invention surprisingly demonstrate pharmaceutically acceptable stability characteristics when stored under controlled room temperature conditions for an extended period of time. Further, the invention provides methods of manufacturing such compositions in both liquid (solution) and gel form, and methods of their use in treating ocular conditions, such as presbyopia.

Abstract: The present disclosure relates to stable, liquid pharmaceutical compositions of losartan or pharmaceutically acceptable salts thereof for oral administration. The present disclosure further provides powder compositions for reconstitution to provide a liquid formulation. In further aspects, the present disclosure relates to processes for preparation of such pharmaceutical compositions, and methods of treating a subject in need of losartan by administration of a formulation described herein.

Abstract: The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.

Abstract: The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the methods of preparation, pharmaceutical composition, combinations and the use of compound formula (I), their stereoisomers, isotopic forms or pharmaceutically acceptable salts thereof.