Abstract: Complexes comprising a coordinated Cu(II) ion are described herein, which are capable of binding to an extracellular portion of Ctr1 such that the complex with the Cu(II) ion is transported through the Ctr1. The complexes may comprise a Cu(II) ion coordinated to a ligand and to a peptide, wherein the peptide is released upon contact of the complex with an extracellular portion of Ctr1, thereby forming a second complex comprising the ligand, the copper ion and the extracellular portion of Ctr1. Further described herein are uses and methods utilizing the complex, in imaging, in radiation therapy, and for determining a redox state of cells.

Abstract: Provided are a hydrogel patch, which controls syneresis of a hydrogel so as to enhance transdermal delivery of an active ingredient and has good physical properties, and a preparation method therefor. The hydrogel patch contains: a hydrogel composed of a mixture of phase A consisting of a crosslinking agent and purified water, phase B consisting of an organic polymer and a polyhydric alcohol, and phase C consisting of a pH adjusting agent and purified water; and a filling solution composed of a mixture of phase D consisting of a humectant and purified water, phase E consisting of a thickener and a polyhydric alcohol, and phase F consisting of a pH adjusting agent and purified water. The hydrogel of composition A is filled with the filling solution of composition C, and the hydrogel of composition B is filled with the filling solution of composition D.

Abstract: Provided is an inorganic powder composite used for a water-in-oil type fine dispersion system which is excellent in emulsification and emulsification stability. The inorganic powder composite includes: an inorganic powder; and a first hydrophobic treatment agent, a second hydrophobic treatment agent, and a hydrophilic treatment agent, which cover at least one part of a surface of the inorganic powder, the first hydrophobic treatment agent is a silicon compound, the second hydrophobic treatment agent is a fatty acid, and the hydrophilic treatment agent is hydrous silica.

Abstract: The invention relates to an anhydrous cosmetic composition comprising anhydrous spheroids having a diameter of 0.1 to 10 mm and having a melting point above 50° C., said spheroids consisting of a cosmetically acceptable lipid matrix, solid at room temperature, comprising: (a) at least one hydrocarbon oil, and optionally a gelling agent for said hydrocarbon oil, and/or (b) at least one wax, said spheroids being dispersed in an immiscible continuous phase comprising at least one silicone oil. More specifically, this cosmetic composition can be a lipstick or a foundation.

Abstract: The present invention provides a topical composition for a nanobubble cosmetic with which functional properties required by various types of cosmetic products can be improved. The present invention is a topical composition for a nanobubble cosmetic to be used in a container equipped with a device mechanism for generating nanobubbles, the topical composition containing a polyoxypropylene diglyceryl ether and ethoxydiglycol, or containing hyaluronic acid or a salt thereof, or containing ethanol and menthol or a derivative thereof, or containing sorbitol and glycerin, or containing phytosteryl/octyldodecyl lauroyl glutamate, or containing glycereth-26, or containing hydrogenated lecithin and polysorbate 20, or containing ethanol and polysorbate 20.

Abstract: Pharmaceutical, odontological, cosmetic and dermatological compositions comprising addition salts of trichloroacetic acid, one or more hydroxyacids and optionally glutamic acid or glutamic acid bioisosteres and phytic acid are useful for the peeling of the gingival collar, skin peeling, for resurfacing, treating skin hyper pigmentation, control sebum production, acne, pore size reduction and reducing the appearance of scars without causing undesirable side effects and contrast in coloration of the treated skin, for stimulation of the fibroblasts, transdermal biorevitalization, stimulation of the production of new collagen, for aesthetic improvement, for skin lightening, skin beautifying, skin firming and skin rejuvenation.

Abstract: The present invention is in the field of antiperspirant compositions, in particular, compositions comprising antiperspirant actives. Disclosed is an anhydrous antiperspirant composition comprising an inorganic polyionic cluster having structure of (I) or (II); where M is Ca or Mg; and wherein the composition is substantially free of abrasives, which means less than 3.0% by weight of the composition; wherein anhydrous means the water content of the composition is less than 3.0%.

Abstract: Disclosed is a topical composition comprising: (i) an antimicrobial active which is at least one of piroctone, caprylhydroxamic acid, benzohydroxamic acid, or piroctone olamine; and (ii) Febrifugine. Also disclosed is a non-therapeutic method of providing topical antimicrobial benefit on a topical surface of a human or animal body comprising a step of applying a safe and effective amount of the topical composition.

Abstract: The present disclosure relates to hair cosmetic compositions comprising: (a) at least one sugar alcohol: (b) at least one saccharide compound, and mixtures thereof; (c) pectin; (d) at least one water-soluble solvent; and (e) water. The hair cosmetic compositions provide excellent hair styling benefits without requiring synthetic film-forming polymers and/or silicones. In particular, the hair cosmetic compositions are useful for imparting to hair, durable styling or shaping benefits, curl definition, curl regularity, shape/styling control, shine, and frizz control.

Abstract: An organic counteranion co-assembly strategy is employed to prepare a hybrid molecular framework. The hybrid molecular framework comprises an ordered arrangement of cyclodextrin (CD), metal cations, and organic anions.

Abstract: The instant disclosure relates to hair cosmetic compositions that include a cationic vinylpyrrolidone copolymer, a cationic thickening agent comprising at least one unit derived from acrylic or methacrylic acid, a cationic surfactant, including a cationizable surfactant; a fatty alcohol, present in an amount of not more than about 3 wt. %; panthenol, an amino functionalized silicone, a plant or vegetable oil, present in an amount of not more than about 4.5 wt. %; and water. Methods for using such hair cosmetic compositions are also provided.

Abstract: Agents, processes, and kits-of-parts are provided for dyeing keratinous material. An agent for dyeing keratinous material includes (a1) at least one non-ionic emulsifier having an HLB value of from 4.0 to 12.0, (a2) at least one pigment, and (a3) at least one amino-functionalized silicone polymer.

Abstract: The present invention is a composition and method of treatment for fragile skin, skin disorders, and skin conditions in general through topical systematic and periodic application of a formulation that generally may include ingredients such as but not limited to barrier repair ingredients such as but not limited to Skinmimics®, Retinol®, and glycolic acid; humectants such as but not limited to glycerin, propanediol, low and high molecular weight hyaluronic acids; redensifying agents such as but not limited to Timecode®, a lipo amino acid (palmitoyl glycine); and anti-inflammatory/anti-itch ingredients such as but not limited to soybean sterols, Timecode®, SymCalmin®, menthyl lactate, and niacinamide.

Abstract: The invention relates to the use of an extract of the fungus Inonotus obliquus for maintaining and/or increasing the cohesion of the skin tissues, for preventing the appearance of and/or for reducing shadows and/or bags in the area around the eyes, for maintaining and/or increasing the radiance and/or homogeneity of the skin complexion and/or for maintaining and/or increasing the barrier function of the skin and/or for increasing the skin microcirculation. The invention also relates to the extract of I. obliquus or a dermatological composition comprising same, for its use for reducing ruddiness and/or for preventing and/or reducing pathologies resulting from a reduction in the cohesion of the skin tissues, notably itching and/or couperosis.

Abstract: The present invention provides topical formulations having an autophagy stimulating and/or heme oxygenase and activating/triggering effect on human skin for cosmetic and pharmaceutical use. Furthermore, the present invention provides topical formulations that trigger production of VEGF-C, reduce melanin synthesis and boost energy and cell function. Moreover, the present invention provides a new process for producing a herbal composition comprising a mixture of components of Bellis perennis L. and optionally Hieracium pilosella by aqueous extraction and the herbal composition comprising a mixture of components produced by the process of the present invention. The pharmaceutical formulations according to the present invention may be used for the treatment or prevention of dark circles under the eye and/or puffy eyes. The herbal composition according to the present invention may also be used in a cosmetic formulation for the cosmetic treatment or prevention of dark circles under the eye and/or puffy eyes.

Abstract: An oral film dosage form includes a high viscosity polymer in an amount of from 1% to 5% by dry weight to reduce, modulate and/or control Cmax of an active agent. The high viscosity polymer has a viscosity of from 100 cps to 500 cps as determined at 2% concentration in water by weight at 25° C. using a Brookfield LVF viscometer with spindle no. 2 at 60 rpm.

Abstract: A composition comprising a liposome comprising a first phospholipid comprising a C14-C19:0 fatty acid and a C3-C15:0 fatty acid with a c-terminal carboxyl or a carboxaldehyde group; a second phospholipid comprising a C14-C19:0 fatty acid and a C14-C19:0 fatty acid and a sterol. The first phospholipid is preferably a phosphatidylcholine. The second phospholipid is preferably HSPC and the sterol is preferably cholesterol. In some embodiments, the molar ratio of the respective ingredients is 2-3:5-6:2-3; preferably 2:6:2; or 3:5:2, respectively. The invention also relates to the use of this composition in the targeting of M2 macrophages.

Abstract: A “nanolipogel” is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. These different incorporated chemical entities can differ dramatically with respect to size and composition. Nanolipogels have been constructed to contain co-encapsulated proteins as well as small hydrophobic drugs within the interior of the lipid bilayer. Agents incorporated within nanolipogels can be released into the milieu in a controlled fashion, for example, nanolipogels provide a means of achieving simultaneous sustained release of agents that differ widely in chemical composition and molecular weight. Additionally, nanolipogels can favorably modulate biodistribution.

Abstract: Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Abstract: Pharmaceutical formulation comprising centanafadine or a pharmaceutically acceptable salt thereof and an excipient, and related methods of manufacture and use, are disclosed.

Abstract: Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or TOP after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.

Abstract: The invention relates to a tablet dosage form for buccal absorption of active ingredients comprising a population of particles and an active ingredient to be released in the oral cavity for absorption through the oral mucosa, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas.

Abstract: This invention is related to an oral pharmaceutical composition that contains a cholinergic agent, a natural plant alkaloid in particular, selected from the group of lobeline, anabasine, cytisine, galantamine or their acceptable salts, in the form of tablets and capsules. The excipients of the developed oral composition include cellulose powder, calcium sulphate, silica colloidal and magnesium stearate, the total content of cellulose powder and calcium sulphate dihydrate being from 64.5 to 97.5% of the mass of the dosage form and at least 90% of the alkaloid particles being ?100 ?m. The oral composition contains also at least one biologically active amino acid selected from: L-carnitine, tryptophan or a combination of them.

Abstract: Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.

Abstract: The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.

Abstract: A melt processed viral nanoparticle construct for delivery of virus or virus-like particles to a site of interest includes a degradable polymer matrix and a plurality of virus or virus-like particles encapsulated within the degradable polymer matrix. The nanoparticle construct upon administration to the site of interest providing a sustained release of the virus or virus-like particles and/or nanoparticles upon degradation of the polymer matrix.

Abstract: An absorbent article such as a baby diaper comprising a three-dimensional laminate 30 having a first layer 1 intermittently bonded to a second layer 2 by a heterophase polymer. The topsheet comprises three-dimensional protrusions 9 in the first layer 1 which are not bonded to the second layer 2. The heterophase polymer has an enthalpy of fusion of at least 10 J/g. The laminate may be used on the wearer-facing side of the article as topsheet 24 and/or on the garment-facing side as part of the backsheet 26. The first layer may comprise natural fibers.

Abstract: An absorbent article having a liquid pervious topsheet wherein at least a portion of the topsheet has been treated to become hydrophobic; a backsheet joined to said topsheet; an absorbent core disposed between said topsheet and said backsheet, said absorbent core having an inner surface oriented toward the skin of the wearer when said absorbent article is being worn and an outer surface oriented toward the garment of the wearer when said absorbent article is being worn; and a surfactant applied to at least a portion of said outer surface of said topsheet wherein the topsheet has been treated hydrophobic and wherein the hydrophilic surfactant is added to the areas treated hydrophobic.

Abstract: A software architecture and system for delivering selected sanitation protocols for multiple pathogens and pests for sanitizing a physical space. The software architecture and system generally includes a plurality of protocol identifiers linked to sanitation protocols arranged as pages in a protocol storage. Each sanitation protocol comprises a plurality of parameters arranged in tabular form for carrying out a sanitation process for one or more pathogens and/or pests. Also included are a control panel/display, controller, heat source, UV light source, and sensors. The protocol identifiers are displayed on the control panel/display and the controller retrieves the parameters of a selected sanitation protocol from the protocol storage. The controller operates in a closed-loop control arrangement with the heat source, UV light source, and sensors to automatically carry out a sanitation process according to the parameters of the selected sanitation protocol.

Abstract: A fuel tank disinfection system, including one or more ultraviolet (UV) light emitters disposed within a fuel tank and configured to irradiate one or more water collecting areas within the fuel tank with UV light; and one or more UV light sensors disposed within the fuel tank and in proximity to the one or more water collecting areas and configured to measure the UV light irradiated on the one or more water collecting areas.

Abstract: The invention relates to a device for irradiating a liquid with electromagnetic radiation, in particular for sterilizing an in particular flowing liquid by means of UV radiation (UV reactor), comprising a container having an inlet for receiving the liquid and having an outlet for releasing the liquid from the container, wherein within the container a variable or adjustable irradiation zone is provided for irradiating the liquid with electromagnetic radiation, in particular UV radiation, emitted by a radiation source. In the irradiation zone the liquid is configured in the form of a liquid layer having the layer thickness which extends between the underside of the container and a gas bubble expanding above the liquid layer.

Abstract: An apparatus includes at least one storage tank configured to store a disinfectant/sanitization solution, at least one pump connected to the at least one storage tank to distribute the disinfectant/sanitization solution via a piping system, at least one valve in communication with the piping system to open and close to control flow of the disinfectant/sanitization solution, at least one device to control the flow of the disinfectant/sanitization solution for a particular period of time to at least one misting nozzle, and the at least one misting nozzle in communication with the piping system and the at least one valve to mist a particular area with the disinfectant/sanitization solution.

Abstract: The application discloses a composition for hard tissue repair comprising a monomer (A), a polymer powder (B) and a polymerization initiator (C), wherein the polymer powder (B) comprises a polymer powder (B-x) having an aspect ratio of 1.10 or more, and the cumulative ratio of powder particles having aspect ratios of 1.00 or more and less than 1.10 in all of the powder particles contained in the composition for hard tissue repair is 75 cumulative % or less, as well as, a kit for hard tissue repair comprising three or more members, in which each of the components of the monomer (A), the polymer powder (B) and the polymerization initiator (C) contained in this composition for hard tissue repair are divided and contained in the members in an optional combination.

Abstract: The present invention relates to a self-assembling polypeptide, such as a silk polypeptide including a spider silk polypeptide, for use as tissue adhesive. The present invention also relates to the use of a self-assembling polypeptide such as a silk polypeptide as tissue adhesive. Further, the invention is directed to the use of a self-assembling polypeptide such as a silk polypeptide to glue one or more cosmetic compounds on skin, mucosa, and/or hair. Furthermore, the invention is directed to a self-assembling polypeptide such as a silk polypeptide for use in gluing one or more pharmaceutical compounds on tissue, skin, mucosa, and/or hair.

Abstract: A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles and a suspending agent comprising hyaluronic acid. The bulking agent results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.

Abstract: Methods, systems and devices associated with a scented electronic candle are described. In one example, an electronic candle includes an outer shell with one or more openings configured to allow a fragrance to exit to an ambient environment of the electronic candle. The outer shell comprises a central opening such that a flame element protrudes at least partially through the central opening. The device includes a light emitting component to emit a light onto the movable flame, and a mounting base positioned below the movable flame element. The device also includes a scent storage component removably coupled to the mounting base. The scent storage component includes a container to store a fragrance and an absorption member configured to draw the fragrance to the ambient environment of the electronic candle through the one or more small openings of the outer shell.

Abstract: A medicament preparation system includes a disposable cartridge with a flow path. Various sensors may be placed on the cartridge to measure qualities of the fluid flowing through the flow path. The sensors are placed in precise locations using various approaches that make manufacturing of the cartridge efficient and repeatable. A drain line that is susceptible to fouling may be preattached and various approaches are used to remove or reduce the fouling. An elastomeric contact can also be present in the medical preparation system and used in a conductivity measurement subsystem.

Abstract: The invention relates to a blood treatment device configured to remove anti-neutrophil cytoplasmic antibodies (ANCAs) from the blood or blood plasma of a person in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix, and wherein said matrix comprises a monomeric form of proteinase 3 (PR3). The invention further relates to an extra-corporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating a medical condition associated with ANCA.

Abstract: Systems and methods are adapted for treating the carotid artery. The systems include interventional catheters and blood vessel access devices that are adapted for transcervical insertion into the carotid artery. Embodiments of the systems and methods can be used in combination with embolic protection systems including blood flow reversal mechanisms, arterial filters, and arterial occlusion devices.

Abstract: Devices and methods establish and facilitate retrograde or reverse flow blood circulation in the region of the carotid artery bifurcation in order to limit or prevent the release of emboli into the cerebral vasculature such as into the internal carotid artery. The methods are particularly useful for interventional procedures performed through a transcarotid approach or transfemoral into the common carotid artery.

Abstract: Filtering cassettes, filtering systems, and methods for using the same are disclosed. An example filtering cassette may include a cassette housing. An inlet may be coupled to the cassette housing. The inlet may be configured to receive cerebrospinal fluid from a catheter. An outlet may be coupled to the cassette housing. The outlet may be configured to direct filtered cerebrospinal fluid to the catheter. One or more filters may be disposed within the cassette housing. An arcuate surface may be defined along a periphery of the cassette housing. The arcuate surface may be configured to engage a controller assembly when the cassette housing is mounted to the controller assembly.

Abstract: Disclosed systems and methods relate to status indication using a canister of negative pressure wound therapy apparatus. A method of providing a visual indication to a user of a negative pressure wound therapy apparatus can include, by a controller of the negative pressure wound therapy apparatus, determining a plurality of conditions associated with provision of negative pressure wound therapy by a negative pressure source of the negative pressure wound therapy apparatus and causing provision of a plurality of visual indications associated with the plurality of conditions to a user and, by at least one light pipe, transmitting light associated with at least one visual indication of the plurality of visual indications through at least a portion of an interior volume of a canister of the negative pressure wound therapy apparatus.

Abstract: An ultrasonic device for an ultrasound-assisted lipoplasty is provided. The ultrasonic device according to one embodiment of the present disclosure includes: a handpiece; an ultrasonic driving unit provided inside the handpiece; a probe including one end portion connected to the ultrasonic driving unit inside the handpiece and configured to extend outward of the handpiece from the one end portion; and a protection unit formed to extend along a longitudinal direction of the probe and to surround an outer circumferential surface of the probe. A heat-insulation member is provided in at least a portion of an inner circumferential surface of the protection unit.

Abstract: An arrangement for activating an aerosol dispenser having a conveying tube for conveying a liquid; a movable holding member holding the conveying tube; a rotatable base; and a container chamber between the holding member and the base, wherein the arrangement is configured to transmit a loading rotation of the base to a substantially axial loading movement of the holding member towards the base, and wherein the holding member has a locking structure exposed to the container chamber. An aerosol dispenser having the arrangement and a method for activating an aerosol dispenser are also provided.

Abstract: Methods and systems for delivering formulations to users using modular device having atomizer and wick assembly are disclosed. A formulation delivery system that includes a mouthpiece with a first attaching structure at one end and a removable cartridge with a second attaching structure that connects to the mouthpiece. The removable cartridge houses an atomizer at its first end and features a wick assembly with a removable cap and a wick made from an absorbent material. The wick, which transports fluid to the atomizer, is connected at one end to the removable cap and at the other end abuts the atomizer. The system also includes a channel within the removable cartridge; this channel extends to the cartridge's first end and houses the wick, while the removable cap is located outside the channel. Additionally, the system incorporates electronics that maintain a removable electrical connection with the cartridge.

Abstract: Traditionally, vital signs monitors in the veterinary setting have been designed for use with human subjects that have simply been repurposed for use in the veterinary space. While some changes may be made to the human monitor to make it more amenable for veterinary use (e.g., changing the monitor display options from “adult” and “pediatric” to “large animal” and “small animal”), these changes are generally only done on a superficial level and thus omit significant veterinary-specific functionality that might otherwise be obtained. Further, vital signs monitors do not include a pre-procedure checklist or any functionality to increase safety awareness and allow clinics to ensure compliance with certain pre-procedure protocols. Accordingly, it is a purpose of the present invention to provide a veterinary-specific vitals signs monitor that overcomes these traditional limitations and increases the ease and efficiency with which veterinary care can be delivered.

Abstract: A directional lock or a headgear or interface assembly comprising one or more directional locks that include a catch arrangement for initiating or assisting in movement of a lock member of the direction lock. In some configurations, the catch arrangement assists movement of the lock member in only a portion of a range of travel of the lock member. In some configurations, the directional lock has a housing and a sleeve and the catch arrangement has a catch arm carried by the sleeve. The catch arm includes a catch end that contacts the lock member, which can be a lock washer in some configurations.

Abstract: A gas humidifier can have a gas channel comprising an inlet and an outlet. A portion of the gas channel can have a region having a reduction in cross-sectional area relative to the portions of the gas channel outside of the region. A water conduit can extend from the region to a water reservoir. A heating element can heat water entering the region from the water conduit. Water vaporized using the heating element can join the flow of gases passing through the gas channel in use.

Abstract: The breathing assistance apparatus of the present invention includes a manifold that is provided with or retrofittable to gases supply and humidifying devices. The manifold allows gases from an oxygen concentrator to be combined with the flow through a gases supply and humidifying device, most usually air. The combined output of oxygen and other breathing gases (air) is then humidified. The breathing assistance apparatus and manifold of the present invention provides a safe method to add oxygen to the input air stream of a gases supply and humidifying device and reduces the amount of accumulation of oxygen within the gases supply device, reducing fire risk should sparking occur within the device.

Abstract: Disclosed herein is an indwelling urinary catheter having a guidewire anchoring mechanism. The indwelling urinary catheter includes a catheter tube having a proximal opening, a distal opening, a catheter tube lumen with the catheter tube having a first wall thickness. The guidewire anchoring mechanism is configured to transition between an insertion state and an anchored state. The guidewire anchoring mechanism can include a proximal portion having a top cap, a collapsible section having a second wall thickness less than the first wall thickness, and a distal portion including a holder cap coupled to a holder. The holder can be coupled to the catheter tube, the distal portion can be in communication with the proximal portion, and a guidewire can be coupled to the proximal portion, the guidewire extending through the catheter tube lumen to the distal portion.