Abstract: A support assembly for use during a medical or surgical procedure. The support assembly includes a base structure and a support structure removably connectable to the support structure through attachment features. In illustrated embodiments, the support structure is attached to the base structure in an upright orientation to form a sideboard or guard and attached to the base structure in a horizontal orientation to form an arm support platform. In illustrated embodiment one or both of the base structure or base board and support structure include attachment features to removably connect a radiation shield for protection against radiation exposure.

Abstract: A cremation box includes a base and a lid. The base has a rectangular bottom section with a pair of long base panels and a pair of short base panels formed by creases in the cardboard. Each of the long base panels has a pair of long base transverse edges cut along lines substantially in line with the creases between the base rectangular bottom section and the short base panels, creating a pair of flaps on opposite sides of the short base panels. When assembled, the flaps are secured to the long base panels to form four corners. The lid has a similar bottom section, long panels and short panels formed by creases, and flaps that form corners. The flaps are secured to the long panels by tabs and cuts in the panels.

Abstract: A funerary method includes disposing a deceased adult human body in supine position on an insert having side walls and end walls. The method further includes providing the insert on a tray having two end panels and a plurality of side panels affixed to a bottom panel, and inserting a first edge of a first fabric segment between a side panel of the tray and a side wall of the insert. The first fabric segment is used to cover at least a portion of a top edge of at least the first side wall of the insert and at least a portion of the deceased human body, such that the deceased human body is sufficiently visible for identification. Thereafter, the insert and the deceased human body are removed from the tray.

Abstract: An embodiment auto sliding ramp for a vehicle includes a drive motor, a clutch rod including a clutch body slidably inserted inside the drive motor and a clutch gear mounted on the clutch body, a motor clutch connecting the drive motor and the clutch rod, a ramp drive unit configured to drive the ramp according to its rotation, a main drive including a drive gear engaged with the ramp drive unit and a drive shaft connected to the drive gear and configured to manually rotate the drive gear, and a clutch operation part configured to disengage the motor clutch by pushing the clutch rod.

Abstract: The embodiments described and claimed herein include an automated securement system that lock a wheeled mobility device into a designated station aboard an autonomous public transit vehicle, thus preventing unintended movement that is discomforting and potentially dangerous for both the WMD user and other passengers. The automated securement system includes features that integrate with typical autonomous public transit vehicles to minimize obstruction during stowage while maximizing effectiveness during deployment.

Abstract: A wheelchair for supporting a user, and for providing movement of the user's arm has a wheelchair body supported by wheels for supporting the user for rolling movement, an armrest for supporting the user's arm thereupon, and a movable mounting mechanism for mounting the armrest on the wheelchair body so that the armrest can move between a first position and a second position. A movement mechanism moves the armrest between the first and second positions.

Abstract: The assistance method using an assistance device including a base, a support section configured to lift and lower the upper body of a care receiver with respect to the base while supporting the upper body of the care receiver from the front, and a driving section configured to drive the support section. The assistance device is configured to be waterproof. The assistance method includes a boarding step for boarding the seated care receiver onto the assistance device; and a rear side washing step for washing the body of the care receiver while the buttocks of the care receiver is lifted by lifting the support section.

Abstract: The present invention relates to the field of lifting mechanisms for beds, and beds incorporating such lifting mechanisms. A lifting mechanism for a bed comprises a leg connecting a foot assembly to a frame for supporting a mattress, the frame defining a support plane; and a linkage mechanism connected between the frame and the leg and configured to allow the frame to move with respect to the foot assembly in a direction perpendicular to the support plane between a raised position and a lowered position. In the lowered position the leg extends parallel to the support plane, and during movement of the frame between the raised and lowered positions the foot assembly does not move in a direction parallel to the support plane.

Abstract: This disclosure provides a patient support for supporting a patient. The patient support comprises a crib assembly comprising a support material with a cover assembly disposed over the crib assembly. The cover assembly defines a recess and comprising a patient support surface having an outer periphery. The patient support further comprises a connector assembly for connecting the patient support to a fluid source with the connector assembly comprising a connector with a plurality of ports. The assembly defines a three dimensional interior corner adjacent the recess in the cover assembly. The connector assembly is disposed in the recess of the cover assembly such that the plurality of ports of the connector are presented for connection to the fluid source at the three dimensional interior corner and inside the outer periphery of the patient support surface.

Abstract: A medical bed includes a bed frame and a powered wheel mounted to the bed frame via a suspended wheel mechanism including an actuator for displacing the powered wheel between a deployed position and a retracted position where a clearance gap is defined between the powered wheel and the floor surface. An end board mounted to the bed frame includes a load cell integrated therein, the load cell detecting a magnitude of a force applied on the end board by a user and providing input signals to a control system. The input signals indicative of the magnitude of the force applied on the end board by the user. The control system is in communication with the powered wheel to drive the powered wheel with a level of power assistance proportional to the magnitude of the force applied on the end board when the powered wheel is in the deployed position.

Abstract: An orthosis device for a subject includes a main housing assembly configured to be worn on an upper extremity of the subject, and a body part interface assembly configured to be secured to the portion of the upper extremity and induce, as actuated by a motor mechanism, flexion and extension motion of the secured body part. A flexible intermediate member is interposed between the main housing assembly and the body part interface assembly, and is configured to flex or extend responsive to actuation by the motor mechanism to cause the body part interface assembly to flex or extend the secured body part.

Abstract: A number of portable anti-cellulite massage devices are disclosed, where the devices are handheld and have four massage rollers which each rotate upon motor-driven eccentric axles to produce synchronized motion. All four rollers produce a percussive massage force in two orthogonal directions at their contact regions with the massage-receiving surface. Each roller has a gripping surface and a slip torque mechanism which allows the roller to partially slip upon its axle during its eccentric rotation cycle. Pairs of rollers rotate eccentrically in opposing directions to produce cyclic stretching and compression forces in the plane of the massage-receiving surface. In one operating mode, the devices produce alternating rising and collapsing skin folds while being traversed along the massage-receiving surface. In an alternate operating mode, the devices may be held stationary to treat a target fascial region by alternately raising a skin fold and then flattening it.

Abstract: A system is disclosed. The system has an accessory control module, comprising computer-executable code stored in non-volatile memory, a processor, a user device of a human viewer, a viewer accessory configured to communicate with the user device, the viewer accessory including a first motor or a first heater, a model device of a human model, and a model accessory configured to communicate with the model device, the model accessory including a second motor or a second heater. The accessory control module, the processor, the user device, the viewer accessory, the model device, and the model accessory are configured to provide a chat communication application between the human viewer and the human model configured to provide chat between the human viewer via the user device and the human model via the model device.

Abstract: An example stimulation device for a male penis includes a pressure field generation device for generating a pneumatic alternating pressure field, and an applicator for applying the alternating pressure field to a portion of a penis that is to be stimulated. The applicator has a pressure chamber, which can receive an alternating pressure field generated by the pressure field generation device. The pressure chamber has an opening in a contact region of the applicator, so that the alternating pressure field can be applied directly to a portion of the penis that is to be stimulated via the opening. A sealing device is arranged on the applicator, which is configured to seal the pressure chamber against the environment when the applicator is applied to the penis.

Abstract: A massage device includes a first massage part and a second massage part, which are configured to be inserted into a vagina or a rectum, and a driving mechanism, which is connected to both the first massage part and the second massage part. The driving mechanism is configured to drive the first massage part and the second massage part respectively to perform reciprocating linear motion simultaneously in opposite directions.

Abstract: A walking assisting system for a user. The system includes first and second sub-systems each having at least one optical sensor, for example a camera. The first sub-system is fitted to the user's abdomen region, for example waist, and the second sub-system is fitted to the user's head region, for example eyes. The system is arranged to align between data obtained from optical sensors of the first and second sub-systems in order to indicate to the user presence of obstacles detected by the first sub-system in a coordinate system of the second sub-system.

Abstract: A rolling walking device for a person with a disability includes a plurality of rollers and at least one support apparatus for the person. The at least one support apparatus is configured so that the person while using the rolling walking device can sit on the at least one support apparatus and simultaneously rest with a front side of their upper body at least partially on the at least one support apparatus with their hip joint flexed.

Abstract: Systems and methods relating to displaying images are disclosed. In one embodiment, sensor data is received via one or more sensors of a wearable head device comprising a display, the sensor data indicative of a surrounding environment of a user of the wearable head device. An image can be determined based on the sensor data, the image corresponding to the surrounding environment. A visibility of a first portion of the image corresponding to a first portion of the surrounding environment can be enhanced. Enhancing a visibility of a second portion of the image corresponding to a second portion of the surrounding environment can be forgone. The enhanced first portion of the image and a view of the second portion of the surrounding environment can be presented concurrently via the display of the wearable head device.

Abstract: Device and method for relieving muscle tension. The device includes three pairs of tips. Each pair is located, relative to the other two pairs of tips, at a vertex in a triangular orientation. Each pair of tips includes a unique horizontal distance in between the tips. Each tip is equidistant in height relative to its respective counterpart tip. The device also includes a connector configured to connect each tip to its counterpart tip. The connector is situated such that there is a pre-determined height differential between the apex of each pair of tips and the top of the connector. The apex of each pair of tips is vertically longer than the height of the connector.

Abstract: Described herein are various embodiments of differential air pressure systems and components for differential air pressure systems. The air pressure systems include a chamber for receiving at least a portion of a user's body. Pressure in the chamber can be changed to adjust force on the user's body. Described herein are various methods and related structures for sealing a user into a pressurizable chamber. Also described herein are various methods and related structures for changing the shape and/or height of the chamber. Described herein are various types and configurations of chambers and support structures for chambers. Also described herein are various methods and related systems for treating various conditions using the differential air pressure systems, including but not limited to obesity, cardiac disease, multiple sclerosis, cerebral palsy, or Down Syndrome.

Abstract: The needless vial assemblies described herein allow for the access to the contents of a vial, such as a medication, using a syringe without a needle. In some designs, the vial includes a vial neck, which is itself a syringe interface. The vial assemblies also include a cap with a plug, which can be used to seal the vial assembly. The present disclosure further provides methods of filling a vial assembly and methods of filling a syringe using the vial assemblies described herein.

Abstract: The present invention relates to a vial that is at least partially filled with an aqueous formulation of a neurotoxin, preferably botulinum toxin, to the manufacture of the vial and to the use thereof. The aqueous formulation of a neurotoxin is stable in the vial for a prolonged period of time.

Abstract: The invention relates to a multi-chamber bag 1 for medical purposes which is formed by films 2, 3, in particular flexible films, that are arranged against one another, are made of an at least partially transparent material and are interconnected in a liquid-tight manner using at least one non-separable seam 5, the bag being divided into at least two chambers 1A, 1B by at least one separable seam 8, by means of which the films arranged against one another are interconnected in a liquid-tight manner. The multi-chamber bag according to the invention is characterised by at least one visually perceptible structure 10 that signals the state of the at least one separable seam 8 and can be easily optically detected. Using this visible structure 10, the user can immediately identify whether the seam 8 is open or closed.

Abstract: A fluid transfer device includes a body having a first connecting portion for connecting with a diluent container, and a second connecting portion for connecting with a medicament container. A first fluid channel extends into the first connecting portion, and a second fluid channel extends into the second connecting portion. A discharge duct is configured to connect to a discharge device. A flow control member is selectively fluidically connectable to the first and second fluid channels, the discharge duct, and a discharge channel. The flow control member is movably disposed in or on the body and is movable relative to the body between first and second control positions. In the first control position, the first and second fluid channels are in fluid communication. In the second control position, the discharge duct is in fluid communication with the discharge channel and the first fluid channel or the second fluid channel.

Abstract: A multi-lumen spike for mixing and reconstituting a medication in a dry state designed to provide the ability for a lay person to aseptically reconstitute a powdered medication for use with an infusion apparatus. The multi-lumen spike can be included as part of a medication mixing and loading apparatus capable of using one or more syringes for reconstituting the medication.

Abstract: Improved feeding set connectors and cassettes are disclosed for use with peristaltic infusion pumps for safely delivering enteral nutritional fluids to a patient. The connectors provide an easy to use “pump-to-set” integration or “keying” system for specific reusable infusion pumps and their matching feeding sets, and can be utilized by medical professionals having various skill levels. The inventive feeding set cassettes can prevent accidental free flow of enteral fluids into a patient, even upon inadvertent release of the connector from the pumping mechanism.

Abstract: A tubing assembly for use with electronic catheter guidance systems is provided and includes a catheter and an acoustic sensor. The catheter extends in a longitudinal direction and has a proximal end and a distal end that define a lumen therebetween. Further, the catheter is configured for placement within a patient's digestive tract. The acoustic sensor can be located within the lumen of the catheter or in a sampling chamber connected to the catheter. The acoustic sensor can communicate with a processor to deliver sound data to a display device. The appearance of random spikes on a frequency versus time spectrogram can indicate placement of the catheter in the digestive tract, while a rhythmic/repetitive pattern on a frequency versus time spectrogram can indicate placement of the catheter in the respiratory tract. A catheter guidance system and method for accurately placing a catheter in the digestive tract are also provided.

Abstract: Systems and methods for making and delivering personalized, medically prescribed pharmaceuticals to an individual patient are described. Individual unit doses (IUDs) of medicine may be prepared specific to the individual in need of same, by using a system, which includes a networked control system in combination with manufacturing assemblies specific to the IUDs and delivering the medicine to the patient directly from the manufacturer.

Abstract: Embodiments provide methods and apparatus for manufacturing a microtablet from a precursor material such as a pharmaceutical powder. Various embodiments provide a method which includes compressing the powder to form a compressed mass of a selected density and repeatedly compacting the compressed mass to increase the density of the compressed mass and form a microtablet. Related methods and apparatus are provided.

Abstract: In one aspect the invention provides an adherence monitoring device for a medication delivery device, the monitoring device including at least one inductive coil sensor which includes at least one inductive controller, at least two inductive coils including a first inductive coil coupled to the housing and a second inductive coil coupled to the housing. The first inductive coil is configured to exhibit a response to an inductive change and provide a first change signal in response to an inductive change, and the second inductive coil is configured to exhibit a response to the inductive change and provide a second change signal in response to the inductive change.

Abstract: An apparatus for feeding an infant in a vertical position is described. The apparatus includes a shoulder support component and a flexible component. The shoulder support component generally has a U-shape with a first side disposed opposite a second side. The second side of the shoulder support component is configured to contact shoulders of a caregiver. The flexible component has a first end disposed opposite a second end. The first end of the flexible component is affixed to the first side of the shoulder support component and the second end includes a bottle holding portion that supports a bottle for feeding an infant in a vertical position.

Abstract: Disclosed herein are compounds and ligands, and compositions formed therewith, that modulate insulin secretion and suppress appetite by activating ectopic olfactory receptors. Also disclosed herein are methods for using the compositions to treat endocrine diseases, such as type-2 diabetes, and disorders, such as abnormal insulin secretion.

Abstract: A formulation of a dietary supplement for the improvement of female fertility in the human species based on the use of a definite stoichiometry of resveratrol with different pharmacokinetic profiles is described. The mixture is used alone or in combination with nutrients with antioxidant properties and not, used in female subfertility such as N-acetil-cysteine; Melatonin Vitamins A, C, D, E, B2, B3, B6, B12, folic acid, inositol, zinc, selenium, Coenzyme QIO, A-lipoic acid, arginine and Lycium barbarum berry extracts.

Abstract: The present invention provides novel pharmaceutical formulations comprising derivatives of NDGA, including M4N (tetra-0-methyl nordihydroguaiaretic acid) and temozolomide and their use in the inhibition and treatment of neoplastic diseases, including glioblastoma multiforme, lung and other cancers.

Abstract: Salts of hexylamine, for example, hexylamine succinate and tri-hexylamine citrate and their method of production are described. The disclosure also relates to compositions comprising hexylamine, for example, for reducing appetite in a human subject, treating obesity in a human subject, preventing obesity in a human subject, preventing weight gain in a human subject, increasing fat loss in a human subject, treating an overweight human subject, increasing athletic performance in a human subject, increasing endurance in a human subject, increasing muscle strength in a human subject, improving cognitive function in a human subject, treating ADHD in a human subject, increasing sweating in a human subject, reducing reaction time of a human subject, increasing psychomotor vigilance of a human subject, enhancing memory in a human subject, increasing central nervous system activity in a human subject, and enhancing alertness, attention, concentration, and/or memory in a human subject.

Abstract: The present disclosure is directed to methods of treating a steatosis- associated disorder by administering a therapeutic agent selected from a lysosomal enzyme, an autophagy-inducing agent, or a combination thereof. Steatosis-associated disorders discussed herein include GSD Ia, GSD Ib, GSD Ic, NAFLD, and NASH. Other embodiments are directed to methods of reversing steatosis, modulating autophagy, inducing autophagy, and reversing glycogen storage.

Abstract: Composition and methods for treatment or prevention of a respiratory infection in a mammal, including a viral infection, like a coronavirus such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or variants thereof. The compositions and methods include a therapeutically effective amount of about a 1% solution of N-chlorotaurine in water. The methods include administering N-chlorotaurine by nasal spray to the nostrils, by oral spray to the throat, and by nebulizer to the lungs.

Abstract: A bactericidal and virucidal pharmaceutical composition for use on epithelial tissues such as pulmonary, nasal and oral tissues, which comprises a non-steroidal anti-inflammatory drug (NSAID) in a concentration between 5 and 500 mM and a salt, being the NSAID preferably solubilized in a hypertonic saline solution applicable in therapies for viral infections of the Herpes simplex type. The composition can be used in therapies for herpes simplex viral infections, be used as a bactericidal mouthwash, or be vehiculated to the lung by using a nebuliser, for cystic fibrosis.

Abstract: The present invention relates to pathogenic bacteria, and is particularly concerned with treating, preventing or ameliorating bacterial infections using novel antibiotic compositions. The invention is especially useful for treating infections of Bacillus and Clostridia species, such as Clostridium difficile, Staphylococcus aureus and Mycobacterium spp. The invention extends to pharmaceutical compositions comprising such formulations. The invention also extends to methods for identifying aerobic Bacillus spp., which exhibit antibacterial activity against other bacteria, such as C. difficile, and to methods for isolating active antibacterial compositions from these aerobic Bacillus spp.

Abstract: In various implementations, cannabidiol, beta-hydroxybutyrate, related compounds, and/or one or more other compounds may be administered to an individual to improve the health of the individual. The beta-hydroxybutyrate may include R-beta-hydroxybutyrate. The beta-hydroxybutyrate may include a salt and a polymer of beta-hydroxybutyrate. Other compounds may include amino acids, fatty acids or esters thereof, and/or combinations thereof.

Abstract: The present invention provides compositions and methods for promoting glycogen synthase activity and augmenting glycogen storage capability in muscle tissue and/or liver tissue in a mammal, relating to administration to the mammal of an effective amount of ?-aminoisobutyric acid (BAIBA), an analog or derivative thereof, or a pharmaceutically acceptable salt, ester, acid, polymer, analog or derivative thereof.

Abstract: A method of reducing symptoms of neurodegenerative disease in a human is provided. The method comprises applying to the human a solution or salve to at least one of the skin, the mouth, the nasal cavities, the lungs, the eyes, or the vagina of the human. The applied solution or salve comprises an effective amount of an isomerized or conjugated linoleic acid cation salt having a conjugated diene for at least a measurable improvement in the movement or mental acuity of the human and a structure of —C?C—C?C—. The measurable improvement in the movement or mental acuity of the human is within 4-6 weeks of the applying of the solution or salve. A method of making the conjugated diene and a device for measuring the reduction of systems is also provided.

Abstract: In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.

Abstract: This invention provides compounds of Formula I wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.

Abstract: Provided are methods for increasing SPINK7 anti-proteinase activity in a target tissue of a subject having an allergic inflammatory condition characterized by inflammation of a squamous epithelium in the target tissue, the method comprising inhibiting kallikrein 5 (KLK5) proteinase activity in the target tissue. Suitable KLK5 inhibitors may include a KLK5-Fc fusion protein, a KLK5 anti-sense polynucleotide, a KLK5-directed miRNA, a KLK5-directed shRNA, a KLK5-directed antibody, or a coumarin compound such as 3-(3-chlorophenyl) carboxy-7-hydroxymethyl coumarin or 3-carboxy-7-hydroxymethyl coumarin.

Abstract: The present disclosure provides certain 2,3-dihydrobenzo[b]thiophene compounds that are Hypoxia Inducible Factor 2? (HIF-2?) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2?. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract: The present invention relates in part a to multiparticulate sprinkle dosage form comprising duloxetine or a pharmaceutically acceptable salt thereof, having higher acid resistance as compared to commercially available delayed release formulations. It further relates to various methods of administering the said multiparticulate sprinkle dosage forms.

Abstract: The disclosure provides crystalline and amorphous forms of aticaprant. Also provided by the disclosure are pharmaceutical compositions comprising the amorphous or crystalline forms, methods of treating major depressive disorder using the amorphous or crystalline forms of aticaprant, amorphous or crystalline forms of aticaprant for use in the treatment of major depressive disorder in a human patient having anhedonia, uses of the amorphous or crystalline forms of aticaprant in the manufacture of a medicament for the treatment of major depressive disorder, and packages or pharmaceutical products comprising (i) amorphous or crystalline forms of aticaprant and (ii) instructions for treating major depressive disorder. In some aspects, the human patient treated as described herein has anhedonia.

Abstract: The disclosure herein provides combination therapies for the treatment of cancers such as Leukemia, lymphoma and triple negative breast cancer. The disclosure provides combination therapies of CDK inhibitors, e.g., a CDK inhibitor represented by Formula (I): or a pharmaceutically acceptable salt thereof together with a BCL-2 inhibitor or proteasome inhibitor for the treatment of cancer.

Abstract: Provided herein are methods of treating non-hemorrhagic closed head injury (NHCHI) with 3,3?-diindolylmethane or an analog thereof. In one embodiment, NHCHI covers Traumatic Brain Injuries (TBIs) including mild to severe concussion, blast injury due to proximity to explosions, cerebral contusion, coup-contrecoup injury, DAI, Second Impact Syndrome, or CHI associated with deceleration injury.