Abstract: Internally pierced formed blisters containing fluid compositions for use in devices to produce a spray or mist delivery of the compositions include internal piercing nozzles that can have significantly reduced channel volume to increase pressure of the fluid forced through the nozzle and provide finer control of spray geometry.

Abstract: A vaporizer includes a thermally conductive anesthetic container and a temperature sensor positioned in the container and in the liquid anesthetic. A breathing-gas delivery tube has a delivery end positioned in the liquid anesthetic at least about 5 mm beneath the top surface of the liquid anesthetic. A heater is positioned outside the container. Control circuitry is configured to receive signals from the temperature sensor and is connected to the heater in order to cause the heater to maintain the temperature of the anesthetic above a predetermined temperature. A method of vaporizing inhalation anesthetic is also provided.

Abstract: An apparatus for supplying a respiratory gas includes a conveyor device for conveying the respiratory gas, a conduit for feeding the respiratory gas conveyed by the conveyor device to a person, and a humidification device for humidifying the respiratory gas. A sensor device is configured to generate a signal indicative of the respiratory gas humidity and a control device is configured to control the humidification device with regard to the signal which is generated by the sensor device. A method of supplying a respiratory gas to a patient, in which the respiratory gas is introduced by means of a conveyor device into the conduit leading to the patient and is humidified, includes operating the conveyor device so that a respiratory gas pressure which is above ambient pressure is provided in the conduit, and adjusting the humidity on the basis of signals indicative of the relative and/or absolute humidity of the respiratory gas generated by the sensor device.

Abstract: A respiratory humidification system that controls the humidity of the outlet gases using an enthalpy based calculation is disclosed herein. The respiratory humidification system includes a controller that can receive data from one or more of an enthalpy sensor, a flow sensor and a temperature sensor. The controller can also receive information relating to the outlet gas enthalpy, which can be calculated from the desired output temperature and humidity. A level of power to be provided to the heating system to achieve the desired output temperature and humidity can be calculated using data from the enthalpy sensor, flow sensor, and temperature sensor, as well as the calculated outlet gas enthalpy.

Abstract: An anesthesia device supplying a first and second anesthetic in a quantitatively settable, controlled manner. A data processing unit with a corresponding display is set up for determining the current concentrations in the plasma or at the site of action from continuously supplied data on the quantities of the anesthetics administered with a module for a pharmacokinetic compartment model calculation and for storing these concentration values. Concentration data is predicted for at least one point in time in the future. An action module provides a curve of an anesthesia action parameter as a function of the concentrations of the anesthetics. A display module displays a diagram showing the sequence of concentration of the first or second anesthetic, and the predicted concentration.

Abstract: An apparatus, method and system for delivering CO2 into an inspiratory gas stream to formulate a blended respiratory gas in a manner that continuously maintains a target CO2 concentration in a volume of the inspired respiratory gas, for example, over the course of a breath or a volumetrically definable part thereof or a series of partial or full breaths.

Abstract: Described here are hand-held, low flow devices for dispensing a therapeutic gas. The devices may be configured to include a gas control assembly for delivering a defined volume of gas at a controlled pressure and flow rate. A nosepiece may be included in the device that is formed of a porous material capable of filtering the dispensed gas, and also diffusing the flow of gas as it travels through the nosepiece and into the nasal cavity. The nosepiece may be configured so that there is substantially no restriction of flow therethrough. Methods for treating various medical conditions and delivering therapeutic gases to the nasal mucosa using hand-held, low flow gas dispenser devices are also described.

Abstract: A nitric oxide delivery device including a valve assembly, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gases containing nitric oxide are also described.

Abstract: A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.

Abstract: A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.

Abstract: An improved medicant delivery system 100 is disclosed wherein the carrier for the medicant is a fluid that can be atomized or vaporized by exposure to heat. The system provides for repeatable dose of medicant, can be stored in any orientation, and/or has an ability to maximize energy efficiency.

Abstract: A ventilator provides breathing support to a patient in an EMG controlled mode, and has an input that receives an EMG signal representative of breathing activity from the patient and a control unit for controlling the ventilation in dependence of said EMG signal. The ventilator has a registration unit that registers the actual breathing support provided from the ventilator to the patient, and the control unit determines if there is asynchrony between the EMG signal and the breathing activity and, in case of asynchrony, causes a switch from EMG controlled ventilation to a second ventilation mode not dependent on the EMG signal. If synchrony is detected the ventilator can return to EMG controlled ventilation.

Abstract: A patient treatment system and method comprising a patient circuit, a pressurizing flow module disposed in the patient circuit, a humidifier disposed in the patient circuit, a monitor, sensors within the patient circuit, and a processor. The patient circuit delivers a flow of gas from a gas source to an airway of a patient. The pressurizing flow module elevates the pressure of the gas within the patient circuit. The humidifier elevates the humidity of the gas in the patient circuit to a circuit humidity level. The monitor monitors at least one parameter of the gas from the gas source. The sensors generate corresponding signals that can be processed to estimate a rate at which vapor is added to the gas in the patient circuit. The processor determines the humidity level of the gas in the patient circuit downstream from the humidifier based on the signals generated by the sensors and the at least one parameter of the gas in the gas source.

Abstract: A respiratory humidifier chamber for use with a breathing assistance apparatus is described. The chamber includes a water-tight vessel having an inlet for receiving gases from the breathing assistance apparatus, and an outlet through which heated humidified gases exit the vessel for delivery to a patient. The chamber has a partition which divides the chamber into upstream and downstream sub-chambers. The sub-chambers are separated by the partition except for an aperture which passes through the partition and allows gaseous communication between the sub-chambers. The downstream sub-chamber includes a heater base which heats a volume of water contained within it. The aperture is located above the volume of water. The upstream sub-chamber contains an internal heater which heats gases passing through it from the inlet to the aperture. At least part of the internal heater is located immediately adjacent the aperture.

Abstract: Methods relating to the power management of positive airway pressure apparatus using a battery are disclosed herein. The methods, in various aspects, are adapted to prolong the delivery of a positive airway pressurized therapy when the positive airway pressure apparatus is operated under battery power.

Abstract: A device and a process for the heating and humidification of gas, especially respiratory gas. Fluid from a fluid reservoir is supplied to a sprinkling type chamber where, for the purpose of humidification, it is moved through the gas. The point is that the fluid is heated by a temperature controlled heater to a preset temperature. In addition to the description of the device, a description of the process underlying the operation of the device is described.

Abstract: The present inventions provide respiratory therapy apparatus that introduce water into the pressurized air delivered to a user during various positive airway pressure therapies and corresponding methods. The respiratory therapy apparatus may be configured to administer one or more positive airway pressure therapies, including: continuous positive airway pressure therapy (CPAP), bi-level positive airway pressure therapy (BPAP), auto positive airway pressure therapy (autoPAP), proportional positive airway pressure therapy (PPAP), and/or other positive airway pressure therapies. The respiratory therapy apparatus may include a user interface that defines an interface passage to communicate pressurized air to the user for inhalation and a humidifier that introduces water into the pressurized air generally at the interface passage. Methods according to the present inventions may include introducing water into the interface passage at one or more humidifier ports disposed about the interface passage.

Abstract: Therapy regimes of a plurality of subjects are remotely monitored and/or managed, wherein the therapy regimes include reception of aerosolized medicament. This enables users such as medical care providers, researchers, clinic administrators, and/or other users to monitor and/or manage the therapy regimes of the plurality of subjects through a centralized access point. This reduces physical requirements of proximity for the users and/or the subjects, alleviates the administrative burden placed on the users to manage and/or monitor individual therapy regimes, and/or provides other enhancements over convention systems.

Abstract: A pressure support device includes a humidification system (10) to control the humidity of a pressurized flow of breathable gas generated by the pressure support device. The humidification system includes a liquid storage chamber (32) and a humidification chamber (34). When in an operational orientation, liquid travels from the liquid storage chamber to the humidification chamber through a serpentine feed path (38) due to gravity. The serpentine shape of feed path halts the flow of liquid responsive to the device being tilted out of an operational orientation.

Abstract: A breathing assistance system is provided for delivering a flow of gases to a user. The system includes a humidifier unit which holds and heats a volume of water, and which in use receives a flow of gases from a gases source via an inlet port. The flow of gases passes through the humidifier and exits via an exit port. The system further having a temperature sensor which measures the temperature of the gases exiting the humidifier unit, an ambient temperature sensor which measures the temperature of gases before they enter the humidifier unit, and a flow sensor which measures the flow rate of the gases stream. The system also has a controller which receives data from the temperature and flow sensors, and which determines a control output in response. The control output is configured to adjust the power to the humidifier unit to achieve a desired output at the humidifier unit exit port.

Abstract: The present invention pertains to a gas blender for blending at least two different gases, the gas blender comprising a first gas control valve (10) for supplying a first gas, a second gas control valve (20) for supplying a second gas, a pressure vessel (40) in fluid communication with the first and second gas control valves (10, 20) to receive and store the first and second gases at above atmospheric pressure, and an output gas control valve (50) in fluid communication with an output of the pressure vessel for supplying the blended gas from the pressure vessel.

Abstract: The invention relates to the field of nitric oxide generation. The present invention particularly relates to a method for generating a stream of gas, the gas comprising oxygen and nitric oxide. According to the invention, an intermittent stream of oxygen comprising gas having at least one gap is provided, in which gap a defined pulse of nitric oxide comprising gas is provided. The pulse of nitric oxide comprising gas is embedded in a first pulse of inert gas being provided before the pulse of nitric oxide comprising gas and a second pulse of inert gas being provided after the pulse of nitric oxide comprising gas, the first pulse of inert gas and the second pulse of inert gas being provided in the gap of the intermittent stream of oxygen comprising gas. The method according to the invention reduces the danger of toxic compounds to be formed in the generated gas stream and furthermore provides a method being usable for therapeutic applications independent from the breathing cycle of a patient.

Abstract: An oscillating positive expiratory pressure apparatus having a housing defining a chamber, a chamber inlet, a chamber outlet, a deformable restrictor member positioned in an exhalation flow path between the chamber inlet and the chamber outlet, and an oscillation member disposed within the chamber. The deformable restrictor member and the oscillation member are moveable between an engaged position, where the oscillation member is in contact with the deformable restrictor member and an disengaged position, where the oscillation member is not in contact with the deformable restrictor member. The deformable restrictor member and the oscillation member move from the engaged position to the disengaged position in response to a first exhalation pressure at the chamber inlet, and move from the disengaged position to an engaged position in response to a second exhalation pressure at the chamber inlet.

Abstract: A method and system for delivering a pharmaceutical gas to a patient. The method and system provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient. The preferred pharmaceutical gases are CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate any further delivery of the pharmaceutical gas or can activate an alarm to alert the user that the known quantity has been delivered. The system also has alarm functions to alert the user of possible malfunctions of the system.

Abstract: A method for controlling a humidifier of a CPAP device including a controller, the method including controlling a heating element in the humidifier with command signals from the controller, sensing a temperature of a fluid in the humidifier with a sensor in the humidifier that transmits signals to the controller, establishing an acceptable operating range for the signal transmitted to the controller, determining whether the transmitted signal is within the acceptable operating range, if the signal is within the acceptable operating range treating the signal as being indicative of the temperature of the fluid in the humidifier and using the signal to control the heating element, and if the signal is outside of the acceptable operating range, the controller determines the humidifier to be unavailable.

Abstract: A method and system for delivering a pharmaceutical gas to a patient. The method and system provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient. The preferred pharmaceutical gases are CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate any further delivery of the pharmaceutical gas or can activate an alarm to alert the user that the known quantity has been delivered. The system also has alarm functions to alert the user of possible malfunctions of the system.

Abstract: A method of detecting a level of anesthesia agent in an anesthesia vaporizer is disclosed. The anesthesia agent forms a column of liquid within an external indicator; the method projects a beam of light into the external indicator. The method further receives the beam of light after the beam of light has traveled through the column of liquid, and detects when the level of anesthesia agent drops below a predetermined level.

Abstract: An fluid sensor to activate and control various components of an inhalation device. The fluid sensor includes an acoustic element, such as a microphone, positioned within said inhalation device to detect fluid within the device and output signals representative of the frequency, direction and/or amplitude of the fluid. These signals control and activate an electrostatic plate and/or a high frequency vibrator.

Abstract: A nitric oxide delivery device including a valve assembly, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gases containing nitric oxide are also described.

Abstract: A gas delivery system including a gas delivery device (100), a control module (200) and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve (107) assembly with a valve and circuit including a memory (134), a processor (122) and a transceiver (120) in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator (400) and a breathing circuit (410). Methods of administering gas are also described.

Abstract: A humidifier includes a heating element including a porous structure of electrically resistive and thermally conductive material configured to substantially vaporise liquid that is passed through the porous structure. The porous structure has a liquid inlet and a vapour outlet. The humidifier further includes an outer housing surrounding at least a portion of the porous structure for containing the liquid and vapour within the porous structure. The porous structure includes a first electrical connector and a second electrical connector, the first and second connectors being configured for receiving electrical power and applying a voltage across the porous structure to generate heat.

Abstract: The present invention comprises a user interface for systems and methods for sedation and analgesia delivery. The user interface receives input from a user of a sedation and analgesia delivery system and relays information regarding the system, the administration of sedation and analgesia, physiological conditions to the user in a context sensitive manner. The information relayed may be displayed to the user on a touch sensitive screen or multi-layer display device. The display may be segregated geographically or may be color coded on the display device where the geographic location and/or color of the displayed information relates further information to the user.

Abstract: In an anesthesia vaporizer for vaporizing an anesthetic agent liquid and a method of vaporizing an anesthetic agent liquid in an vaporizer, an evaporation unit evaporates the anesthetic agent, a delivery unit intermittently adds a volume of said liquid to the evaporation unit in order to evaporate at least a portion of the volume of the liquid from the evaporation unit. A heat energy storage unit includes a phase change material (PCM) and is thermally coupled to at least a portion of the evaporation unit. The PCM has a phase shift temperature that is higher than the evaporation temperature of the anesthetic agent. The PCM in the heat energy storage unit is preferably at least partly liquid at an operative temperature of the vaporizer.

Abstract: An apparatus for providing nebulized medicant to a user is disclosed. The apparatus may include an air intake for drawing an air flow into the inhalation device. The apparatus may also include a medicant reservoir for receiving liquid medicant. The apparatus may further include a nebulizer for nebulizing the liquid medicant into the air flow. The apparatus may additionally include a mouthpiece for delivering the air flow with nebulized medicant to the user. The apparatus may furthermore include a communication interface configured to receive at least a first signal from a mobile device causing activation of the nebulizer.

Abstract: The invention provides a fail-safe module (FSM) integral with a sedation and analgesia system that meets the high-reliability needs of sedation and/or analgesia delivered by non-anesthetist practitioners. The FSM may operate in “real-time” in order to ensure optimal patient safety. The FSM may deactivate specific patient interfaces, user interfaces, and/or sedation and analgesia delivery in order to ensure patient safety and has redundant safety systems in order to provide the fail-safe module with an accurate assessment of controller functionality.

Abstract: Provided are systems for humidifying gas delivered to a patient. A humidifier unit (107) is provided located proximal to a patient interface (105) of a patient circuit (103). The humidifier unit includes a chamber that receives water from a water source (109), a heat source disposed within the chamber, a water flow sensor (113), an output temperature sensor (117), an output humidity sensor, and/or other sensors. A controller (119) receives flow data relating to water being provided to the chamber and temperature data relating to the temperature of the humidified gas, humidity, and/or other data. The controller further adjusts a flow of water being provided to the chamber based on the flow data and/or a heat output of the heat source based on the received data.

Abstract: Described are methods for safer nitric oxide delivery, as well as apparatuses for performing these methods. The methods may include detecting the presence or absence of a nasal cannula, and stopping the delivery of nitric oxide or providing an alert if the cannula is disconnected. The methods may also include purging the nasal cannula if it is reconnected after a disconnection or if it is replaced by a new cannula. Other methods pertain to automatic purging of the delivery conduit if the elapsed time between successive deliveries of therapeutic gas exceeds a predetermined period of time.

Abstract: A method for delivering a therapeutic or medicinal substance, comprising sensing a patient to generate a sleep stage signal indicating a patient's sleep stage, and releasing and/or delivering a therapeutic or medicinal substance via the patient's airways in accordance with the sleep stage signal.

Abstract: A dose counter for a metered dose inhaler includes a force sensor, an electronic controller, a memory for storing data indicative of a remaining number of doses and an electronic display device coupled to the controller for displaying the remaining number of doses. The dose counter is attached or integrated into a base of a canister containing medicament such that force applied to the base of the canister is registered by the force sensor, the controller being configured to measure force applied to the dose counter when depressing the canister and being responsive to measured force to decrement the remaining number of doses stored in the memory and shown on the display device.

Abstract: The present invention is directed to the administration of aerosolized particles to specific area of the lungs, and in particular to the targeted delivery of aerosolized pharmaceutical formulations to a specific area of the lungs. More specifically, the present invention relates to devices and methods for depositing aerosolized particles to a specific area of the lungs by regulating aerosolizing parameters of the device. The present invention also relates to devices, systems and methods for disease management, where the aerosolizing parameters are adjusted based on monitoring at least one health parameter.

Abstract: An apparatus for producing gas for use in medical applications. The apparatus includes a compressed gas unit having at least one container of compressed gas and a solenoid valve. An adjustable pressure regulator communicably connected to the gas container, separate and distinct from the solenoid valve, is adjusted to control the pressure of the gas provided from the container to the solenoid valve. An electrical power source is connected to the solenoid valve. A pressure activated electronic switch connected to the power source is responsive to a selected amount of voluntary fingertip, pressure for opening the solenoid valve to transmit the gas therethrough to a conduit, which further transmits the gas to a destination for use or storage.

Abstract: An apparatus for metering the delivery of an aerosol. The apparatus has a variable acoustic source and a microphone, both acoustically coupled to a volume having a fluid region and an air region. The apparatus may also include a processor to determine a volume of the air region based on signals received from the microphone and the variable acoustic source. A fluid valve is coupled to the processor, and is configured to allow an amount of fluid to exit the fluid region associated with the volume of the air region. An atomizer, coupled to the fluid region, is configured to aerosolize at least a portion of the fluid.

Abstract: There is provided a liquid formulation ejection device which improves reliability of inhalation even in a case where a preejection is performed and resolves a concern about hygiene. The liquid formulation ejection device (1) ejects a liquid formulation in a form of liquid droplets into an inhalation flow path (20) and allows a user to inhale the formulation. The liquid formulation ejection device (1) includes an ejector (11) for performing normal liquid droplet ejection for inhalation and liquid droplet preejection not for inhalation, and a discharger (13, 14, 28) for removing liquid droplets ejected by the liquid droplet preejection out of an inside of the inhalation flow path (20).

Abstract: Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises a display that provides a visual and/or numeric indication of the calculated dose of nitric oxide. Also described is a method of monitoring nitric oxide delivery, wherein the breathing gas flow rate and therapeutic gas flow rate are measured and used to determine the calculated dose of nitric oxide, which is then displayed. In some embodiments, an alert is provided when the calculated dose rises above or falls below a predetermined level or range.

Abstract: An aerosol delivery system (e.g., MDI or nebulizer for delivering aerosolized medication to a patient) includes a temperature sensor (10) in an aerosol output pathway of the system. A controller (600) determines that an aerosol generator of the system has released aerosol when the sensor senses a predetermined temperature change in the pathway. The temperature sensor may also comprise a thermal flow sensor that includes a heater and upstream and downstream temperature sensors. The controller compares the upstream and downstream temperatures to determine the presence, direction, and/or magnitude of fluid flow in the pathway. The controller may use the aerosol detection and/or flow detection to monitor compliance with desired use of the system and/or provide real-time instructions to a user for proper use of the system. The controller may record the aerosolization and flow data for later analysis.

Abstract: This disclosure describes systems and methods for ventilating a patient with a system that includes an accumulator for storing a gas mixture. The disclosure further describes a novel approach for a fast delivery of a change in gas mixture to a patient by utilizing a variable-sized accumulator.

Abstract: Described are methods and systems for delivering a pharmaceutical gas to a patient. The methods and systems provide varying quantities of pharmaceutical gas delivered to the patient in two or more breaths based on the monitored respiratory rate or changes in the patient's respiratory rate.

Abstract: Described here are unit dose containers, methods, and kits for treating asthma and other pulmonary conditions by nebulization. The unit doses of active agents are provided in a low volume formulation, which results in faster nebulization of the unit doses. The containers are also formed to minimize internal surface area so that effective re-dispersion of the active agents can be achieved while reducing adsorption to the walls of the containers.

Abstract: A therapeutic vaporizer is disclosed having two or more housing portions configured to form an inner cavity. The housing portions are movable between an open and closed position, such that at least a portion of the inner cavity is enclosed when the housing portions are in the closed position. The vaporizer includes at least one accessory-receiving element configured to receive at least one accessory within the inner cavity when the housing portions are in the closed position.

Abstract: The invention relates to a method of determining water level in a humidifier chamber that is part of a humidified gases delivery apparatus and system. The method comprising the steps of delivering power to a heater plate, varying the power delivered to the heater plate, measuring the rate of change of temperature and determining the level of water based on the heating characteristics of the volume of water within the chamber, in particular determining the level of water within the chamber based on the rate of change of temperature and the supplied power.