Particulate Treating Agent Carried By Breathed Gas Patents (Class 128/203.15)
  • Patent number: 10398859
    Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a p
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: September 3, 2019
    Assignee: OptiNose AS
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
  • Patent number: 10384027
    Abstract: A semi-malleable nasal mask system which includes an internal support structure for providing a uniform-like sealing force around the user's nose and nose area.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: August 20, 2019
    Assignee: Breas Medical, Inc.
    Inventor: Donald Harrison
  • Patent number: 10376660
    Abstract: Taught herein is a disposable breath actuated dry powder drug inhalation device having a powderized drug storage chamber with integral toroidal geometry and air flow pathways for entraining and breaking up powder aggregates prior to delivery to the patient. The toroidal chamber is fluidly connected by one or more air inlets directed in a non-tangent manner toward the powder to loft and set up an irregular-rotational flow pattern. Also, in fluid connection with the toroidal chamber is a centrally or near centrally located air and powder outlet consisting of one or more holes forming a grid in fluid connection with a channel providing a passageway for powder flow to the patient.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: August 13, 2019
    Assignee: Concentrx Pharmaceuticals, Inc.
    Inventor: Eric Carl Richardson
  • Patent number: 10376661
    Abstract: An opening element for opening an ampoule in an aerosol generation device includes a first member which has a conduit extending therethrough for guiding a fluid contained in the ampoule through the first member and a second member which is arranged at least partly inside or on the conduit. Further, an aerosol generation device includes such an opening element.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: August 13, 2019
    Assignee: PARI Pharma GmbH
    Inventors: Thomas Gallem, Uwe Hetzer, Stephen Pham, Reynaldo Quintana
  • Patent number: 10375991
    Abstract: An electronic inhalation device includes an outer housing extending in a longitudinal direction, an air inlet, an outlet, a formulation, and an abrasive element, which contacts a surface of the formulation. The abrasive element is configured to generate a particle cloud from the formulation by removing particles from the formulation and entraining the particles in an air flow.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: August 13, 2019
    Assignee: Altria Client Services LLC
    Inventor: Peter Lipowicz
  • Patent number: 10349677
    Abstract: There is provided an aerosol generating system, the system comprising: aerosol generating means; aerosol delivery means; and an aerosol guiding device. The aerosol guiding device (1) comprises a chamber (10) having an air inlet (11) and an air outlet (12), the aerosol delivery means is configured such that aerosol is introduced from the aerosol generating means into the chamber in use at its narrowest part (13), and an airflow route is defined from the air inlet to the air outlet so as to convey the aerosol to the air outlet. There is also provided an aerosol guiding device for use in an aerosol generating system, the device comprising: a chamber having an air inlet and an air outlet. Aerosol is introduced from an aerosol generating means into the chamber in use at its narrowest part, and an airflow route is defined from the air inlet to the air outlet so as to convey the aerosol to the air outlet.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: July 16, 2019
    Assignee: JT International S.A.
    Inventor: Andrew Robert John Rogan
  • Patent number: 10342937
    Abstract: A fluid dispenser device including a body and a cover that pivots between a closed position and an open position and reservoirs each containing a dose of fluid. The reservoirs are arranged on a strip and an opening mechanism is provided. The device includes a movable support to move a reservoir against the opening mechanism. The movable support is movable between a non-dispensing position and a dispensing position. The device includes a strip-rolling system having a drum and an actuator member. The actuator member turning relative to the body in a first direction when the movable support is moved from the non-dispensing position towards the dispensing position, and in a second direction when the movable support is moved from their dispensing position towards the non-dispensing position. The actuator member causes the drum to turn only when turning in the second turning direction.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: July 9, 2019
    Assignee: APTAR FRANCE SAS
    Inventors: Arnaud Colomb, Maxime Kirniak
  • Patent number: 10344055
    Abstract: Described is a composition comprising—a peptide which consists of 7-17 adjacent amino acids and comprises the hexamer TX1EX2X3E, where X1, X2 and X3 can be any natural or non-natural amino acid, and the peptide is cyclized and does not exhibit TNF receptor binding activity, and—an inhibitor of viral neuraminidase.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: July 9, 2019
    Assignee: Apeptico Forschung UND Entwicklung GMBH
    Inventors: Bernhard Fischer, Rudolf Lucas, Hendrik Fischer
  • Patent number: 10335558
    Abstract: Embodiments disclosed herein are directed to methods, compositions and apparatus for administering active agents to the lungs of a subject.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: July 2, 2019
    Inventors: Richard C. Boucher, Michael Ross Johnson, William R. Thelin, Brian Button, Tomas Navratil
  • Patent number: 10300228
    Abstract: A thermally modulating inhalable medicament delivery device may deliver an inhalable medicament as an aerosol, vapor, or partial aerosol and partial vapor mixture. The inhalable medicament may be delivered to a target in a subject. Described herein are devices, systems, and methods for delivering an inhalable medicament to a subject.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: May 28, 2019
    Inventor: Noah Mark Minskoff
  • Patent number: 10286164
    Abstract: A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: May 14, 2019
    Assignee: OptiNose AS
    Inventor: Per Gisle Djupesland
  • Patent number: 10267723
    Abstract: A particle detector that includes a housing defining a chamber, and an air stream injector, producing an airstream with entrained particles, in the chamber. A light source produces a light beam that intersects with and is wider than the air stream. A light detection assembly detects light generated by scattering of the light beam, by particles in the air stream. A digitizer produces a sequence of scattering digital values, each representing light detected per a first unit of time duration. Additionally, a summing assembly produces a sequence of summed scattering digital values, each equaling a sum of a sequential set of n of the digital values, and wherein successive summed digital values are offset by a the first unit of time duration and overlap by n?1 of the first units of time duration with a nearest neighbor. Finally, a detection assembly processes the summed scattering digital values to detect particles.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: April 23, 2019
    Inventors: Elric Saaski, Dor Yacobi
  • Patent number: 10258752
    Abstract: Embodiments of an inhaler device include a housing, a withdrawing assembly disposed within the housing for facilitating withdrawal of medicament from a target blister of a blister strip, the withdrawing assembly including an opening element adapted for opening the target blister of the blister strip while the target blister is positioned in the withdrawing assembly, and a dispensing element adapted for directing the withdrawn medicament toward the exterior of the inhaler device. A blister track is disposed within the housing for guiding each blister of the blister strip to the withdrawing assembly in succession, an advancing mechanism for advancing the blister strip by a predetermined distance each time the advancing mechanism is engaged, and an engaging element for engaging the advancing mechanism to advance the blister strip. The blister track includes a primary coil structure, a secondary coil structure, and a tertiary coil structure.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: April 16, 2019
    Assignee: Novartis AG
    Inventors: Mark Glusker, Victoria Quitugua
  • Patent number: 10245394
    Abstract: Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing, mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: April 2, 2019
    Inventors: Mark Glusker, George S Axford, William W Alston, John Palmer-Felgate, Jonathan Wilkins, Willard R Foss, Nagaraja Rao, Mark Postich, Neeraj Pakala, David S Maltz, Keith Ung
  • Patent number: 10238577
    Abstract: Devices for delivery of fluid compositions include a delivery device including an internally pierced blister in which the device includes a plunger configured to crush the blister and deliver the contents in a lateral direction with respect to the motion of a dispensing button. Certain devices are configured for oral delivery.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: March 26, 2019
    Inventors: Jeff Gjertsen, Timothy Sullivan
  • Patent number: 10238820
    Abstract: An improved dry-powder inhalation device having a casing having an air inlet located at a first terminus; a powder delivery port located at a second terminus, which is positioned distal to the air inlet; and an elongated support panel located within an interior of the casing and being fitted within the casing so as to partially rotate therein about a single axis. The support panel has at least one compartment containing dry-powder located proximally to the second terminus, and the casing has a plurality of needle-like structures located proximal to the delivery port and arranged above the dry-powder compartment. The compartment with a dry-powder includes a blister structure encasing the dry-powder, whereby airflow through the device causes the elongated support panel to partially rotate repeatedly within the casing, thereby striking the plurality of needle-like structures and releasing the dry-powder in the airflow.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: March 26, 2019
    Assignee: Seroton, Inc.
    Inventor: David R. Elmaleh
  • Patent number: 10222116
    Abstract: An insulation delivery apparatus for forming an insulated appliance structure includes an insulated structure having a wrapper and a liner that define an interior cavity and a hopper having a storage bin and a delivery mechanism. The delivery mechanism delivers an insulating medium from the storage bin, through an insulation conduit and into the interior cavity. The delivery mechanism operates between idle and delivery states. A pressing mechanism is coupled with the insulation conduit and is in selective engagement with the insulated structure. The pressing mechanism operates between rest and compressing states. An inner support is in selective engagement with an outer surface of the inner liner and an operable outer support in selective engagement with the outer wrapper. The inner support and the operable outer support provide structural support to the insulated structure when the pressing mechanism is in the compressing state.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: March 5, 2019
    Assignee: Whirlpool Corporation
    Inventors: Berhanu Allo, Mohamed Alshourbagy, Jon M. Anthony, Lakshya J. Deka, Abhay Naik, Lorraine J. Westlake
  • Patent number: 10207065
    Abstract: A mouthpiece (10) for an inhaler or inhalation device (100) includes an elongated body (12) having a substantially oval opening (14) at a first end and a substantially round opening (18) at a second end opposite from the first end, a plurality of depending arms (24), extending from the elongated body forming at least one air passageway (26) between two depending arms (24), and at least one flexible gripping finger (32) coupled to an inner surface of each depending arm (24), extending inwardly into the medicament delivery passageway of the mouthpiece at or near the substantially round opening (18) at the opposite end. Once coupled with an inhaler or inhalation device, the mouthpiece functions as a “pass through” mouthpiece to improve the consistency of inhaled medicament/drug delivery.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: February 19, 2019
    Inventors: H. Stuart Campbell, John H. Silva
  • Patent number: 10207066
    Abstract: An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism within the housing. The puncturing mechanism comprises an alignment guide and a puncture member, wherein the alignment guide comprises a surface adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: February 19, 2019
    Assignee: BGP Products Operations GmbH
    Inventors: Michael John Dunkley, Jon David Tuckwell, Edward William Vernon-Harcourt, Mark Glusker, Steve Paboojian
  • Patent number: 10188810
    Abstract: An inhaler comprising a housing defining a chamber to receive a strip having a plurality of blisters each containing a dose of medicament for inhalation by a user is disclosed. It comprises an actuating lever and a blister strip drive member rotatably mounted in the chamber to sequentially move each blister into a blister opening position. The blister strip drive member and the actuating lever comprise a drive gear and a drive gear element, respectively, that cooperate to effect rotation of the blister strip drive member in response to rotation of the actuating lever. The drive gear and drive gear element are disposed on the outside of the housing remote from the chamber.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: January 29, 2019
    Inventors: Andreas Meliniotis, Stephen Eason, Roger Clarke, Liam McGuinness
  • Patent number: 10166350
    Abstract: A method of flowing a medicament including dry powder using gas, including preparing a medicament capsule with designated inflow and outflow apertures, introducing a volume of a gas to within a medicament capsule according to one or more release conditions, and releasing a therapeutically effective amount of the powder using the gas. In some embodiments, the medicament capsule apertures are prepared and/or gas delivered to it so that deagglomeration potentially occurs largely within the energetic flow conditions of the capsule, without significant trapping of residual powder by structures such as aperture edge irregularities.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: January 1, 2019
    Assignee: Inspiro Medical Ltd.
    Inventor: Nimrod Kaufmann
  • Patent number: 10124130
    Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: November 13, 2018
    Assignee: Pfizer Limited
    Inventors: Peter J. Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
  • Patent number: 10112019
    Abstract: An inhaler for use with a dry powder pharmaceutical formulation, including: a chamber containing the dry powder formulation, a valve disposed in series with the chamber for regulating air flow through the chamber, and a bypass coupled around the combination of the chamber and the valve, where the valve and bypass cooperate for ensuring that the air flow is at least essentially fixed or kept constant or at a minimum accepted or desired or required flow rate through the chamber, and for varying air flow restriction through the inhaler with flow rate, or for keeping the air flow restriction generally constant.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: October 30, 2018
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Stephen T. Dunne
  • Patent number: 10112020
    Abstract: An airflow adaptor for a breath-actuated dry powder inhaler. The airflow adaptor includes a conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further includes provisions for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: October 30, 2018
    Assignee: Norton Healthcare Limited
    Inventors: Julian Alexander Blair, Daniel Buck, Jan Geert Hazenberg, Xian-Ming Zeng
  • Patent number: 10099024
    Abstract: A nasal delivery device can include air-receiving section that has a first passageway therethrough to allow air to pass through the air-receiving section, a powder-reservoir receiving section sized to receive a powder reservoir, and a powder-delivery section that has a second passageway therethrough to allow aerosolized powder from the powder reservoir to pass through the powder-delivery section. The first passageway can have a first end and a second end, with the first end being further from the powder-reservoir receiving section and the second end being at or near the powder-reservoir receiving area. The second end of the air-receiving section can include a flattened region so that air exiting the air-receiving section has a generally flattened profile.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: October 16, 2018
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Creare, Incorporated
    Inventors: Mark J. Papania, James J. Barry, Mark C. Bagley, Darin A. Knaus, Eric M. Friets, Edward Moynihan
  • Patent number: 10099021
    Abstract: An inhaler device of a powdered substance contained in a capsule comprises a capsule seat suitable for receiving the capsule, said capsule seat being made in two parts which can be reciprocally distanced, each capsule seat part being suitable for retaining a respective capsule part. Means of separation are operable to cause the distancing of said two capsule seat parts.
    Type: Grant
    Filed: October 2, 2012
    Date of Patent: October 16, 2018
    Inventor: Mauro Colosio
  • Patent number: 10058662
    Abstract: A fluid dispenser device including a body (10) and at least one cover element (11, 12) that is mounted to pivot on said body (10) between a closed position and an open position, said device including at least one individual reservoir containing a single dose of fluid, such as powder, opening means (80) being provided for opening an individual reservoir each time the device is actuated, said device including movable support means (50) that are adapted to move an individual reservoir against said opening means (80) on each actuation, said movable support means (50) being displaceable between a non-dispensing position and a dispensing position, said movable support means (50) being urged towards their dispensing position by resilient means (70), such as a spring or a spring blade, and being held in their non-dispensing position by blocking means that are released by the user inhaling, said device including a cocking member (800) that co-operates with said resilient means (70) and with a cam surface (51) that is
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: August 28, 2018
    Assignee: APTAR FRANCE SAS
    Inventor: Arnaud Colomb
  • Patent number: 10046124
    Abstract: An inhaler, preferably for insertion into a nostril, in particular a horse's nostril, with a pressure generator, which has a tensioning device for the drive, and with a tensioning mechanism for tensioning the tensioning device, whereby the tensioning mechanism has a lever gear for tensioning the tensioning device.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: August 14, 2018
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Marcus Knell, Michael Aven, Benjamin Franzmann, Steffen Schuy, Herbert Wachtel, Guido Endert, Alexander Christ, Horst Wergen
  • Patent number: 10039318
    Abstract: An electronic cigarette allows for replacing a spent liquid capsule or container with a new capsule, without requiring the user to touch the spent capsule. A capsule is positioned on a capsule seat on or in the housing of the electronic cigarette. After the liquid in the capsule is consumed and the capsule is spent, the mouthpiece of the electronic cigarette is removed, The spent cartridge is captive in the mouthpiece so that it is removed with the mouthpiece. A fresh capsule is placed on the capsule seat. As the mouthpiece is reattached to the housing, the spent cartridge is ejected out of the mouthpiece. An absorber in the mouthpiece may be provided to absorb any condensed vapor liquid.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: August 7, 2018
    Assignee: FONTEM HOLDINGS 1 B.V.
    Inventor: Neha Daryani
  • Patent number: 10010687
    Abstract: A device for inhaling powdery substances, in particular of a medical nature, contained in capsules, can be brought into an emptying position via a receptacle that can be moved in a flat housing, in which position the capsule wall can be pierced via movable needles for the purpose of sucking out the capsule content through a mouthpiece channel, which extends in axial extension of the capsule chamber. The receptacle is designed as a part of the narrow lateral wall of the flat housing that can be pivoted out to a limited extent about an axis and a partial region of the narrow lateral wall plane is designed as a spring-loaded push-button for the needle bearings, in such a way that the partial region moves back to the plane of the narrow lateral wall at a maximum.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: July 3, 2018
    Inventor: Alfred Von Schuckmann
  • Patent number: 9993601
    Abstract: Disclosed is an inhaler and a method for using the inhaler for the inhalation of a formulation from a carrier. The carrier contains the formulation in a receptacle and is set oscillating by an air current. An improved or defined delivery and nebulisation of the preferably powdered formulation is made possible by the fact that the carrier is set oscillating in defined manner, the formulation is dispensed through a cover element having three to five holes and/or the air current flows onto a fin associated with the carrier and flows past at least substantially only one flat side of the carrier.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: June 12, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Andree Jung, Stephen Terence Dunne
  • Patent number: 9987440
    Abstract: Disclosed herein are inhalation devices and methods for storage and release of substances in powder form such as a drug. The inhalation devices can include a plurality of powder chambers for storing a respective dose of a preloaded powdery substance, and an uncovering device for dispensing one dose at a time. The inhalation devices can include an advancing mechanism is arranged to feed the dose ring one powder chamber at a time. The powder chambers can be oriented in the surface of the dose ring and at least one seal is arranged to seal the powder chambers. The powder chambers can be uncovered or opened to at least a portion of an air channel, and the content of the powder chamber is exposed to, and can pass through, the air channel by means of an air flow.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: June 5, 2018
    Assignee: Simplified Solutions Sweden AB
    Inventors: Jan Åberg, Yutaka Kataoka, Jan Hedegaard-Broch, Stefan Fransson, Ulf Rytterholm
  • Patent number: 9981091
    Abstract: A dry powder inhaler including a main body, a plurality of individual reservoirs, such as blisters, each containing a single dose of powder, and disposed one behind another on a flexible strip, and an opening mechanism provided for opening an individual reservoir each time the device is actuated. The device includes first a displacement mechanism adapted to displace an individual reservoir to face the opening mechanism before and/or after each actuation, and a second displacement mechanism adapted to displace an individual reservoir against the opening mechanism on each actuation. The first displacement mechanism having an indexer wheel provided with a recess that receives an individual reservoir, the recess defined by a bottom wall and an inner side wall of said indexer wheel, and by an outer side wall formed on a separate adjustment element assembled on the indexer wheel.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: May 29, 2018
    Assignee: APTAR FRANCE SAS
    Inventors: Arnaud Colomb, Matthieu Baillet, Maxime Kirniak, Antoine Laut
  • Patent number: 9919116
    Abstract: An inhaler is disclosed. It comprises a housing to receive a strip having a plurality of blisters, each blister having a breachable lid and containing a dose of medicament for inhalation by a user, an indexing wheel mounted in the housing rotatable to drive a strip to sequentially move blisters into alignment with a blister piercing member, a control element pivotally mounted to the housing and a drive mechanism configured to couple the control element to the indexing wheel during part of the rotation of the control element by a user so that the indexing wheel rotates together with the control element.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: March 20, 2018
    Assignee: Vectura Delivery Devices Limited
    Inventors: Stephen Eason, Peter Evans, Graham Gibbins
  • Patent number: 9889087
    Abstract: A method of improving cognition in a patient with Down syndrome, which entails intranasally administering one or more ?2-ADR agonists or pharmaceutically-acceptable salts of either or both to the patient in an amount and with a frequency effective to improve cognition of the patient as measured contextual learning tests.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: February 13, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ahmad Salehi, Brian Medina, Van Dang, Devsmita Das
  • Patent number: 9889094
    Abstract: A stable crystalline micronized particulate of a glycopyrronium salt may be prepared by suspending the drug in a water-immiscible anti-solvent in which the drug has little or no solubility and micronizing the suspension. The resulting drug particles are physically stable with regard to agglomeration and/or aggregation on storage.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: February 13, 2018
    Inventors: Irene Pasquali, Andrea Casazza, Elena Losi, Mark Saunders
  • Patent number: 9872963
    Abstract: A fluid dispenser, including a cover element; a blister strip; a blister opening mechanism; a first displacement mechanism having an indexer wheel; a second displacement mechanism pivoting between a non-dispensing position and a dispensing position; a cocking member for urging the second displacement mechanism towards the dispensing position, the cocking member spring-loaded by opening the cover; a blocking mechanism for retaining the second displacement mechanism in the non-dispensing position; a trigger mechanism for releasing the blocking mechanism; a slidable carriage displaceable between a non-indexing position and an indexing position and including an actuator co-operating with the indexer wheel; a connection mechanism activated during inhalation that connects the carriage with the cover, so as to displace said carriage towards its indexing position when the cover element is brought towards its closed position, and so as to displace said carriage towards its non-indexing position when brought towards it
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: January 23, 2018
    Assignee: APTAR FRANCE SAS
    Inventor: Maxime Kirniak
  • Patent number: 9861578
    Abstract: A device for self-administration of fractional amounts of a total volume dose of liquid medicament supplied from a capsule over a period of time for delivery to the sublingual area of a patient. The device contains an inner chamber and a track within which confines a moveable ball. The space between the chamber wall and track permits liquid medication from the capsule to flow past the ball and be available for discharge through an exit port when the ball is not seated upon the exit port.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: January 9, 2018
    Inventor: Yuri Issac Busiashvili
  • Patent number: 9845187
    Abstract: Aerosolizing delivery apparatuses can include cartridges configured to be detachably connected to a delivery device. The cartridges can include: a housing defining a reservoir and a cartridge outlet, the cartridge outlet configured to permit fluid communication between the reservoir and an exterior of the cartridge. A surface of the housing can be configured to define a bypass port between the housing and a surface of the delivery device when the cartridge is assembled with the delivery device.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: December 19, 2017
    Assignee: AERODESIGNS, INC.
    Inventors: David A. Edwards, Cecily Lalor, Richard L. Miller, Gavin McKeown
  • Patent number: 9839241
    Abstract: Provided herein is a system that includes a metered dose inhaler device for pulmonary delivering to a subject at least one pre-determined vaporized amount of at least one pharmacologically active agent being in a plant material, wherein vaporization is effected by controllably heating the plant material so as to vaporize a pre-determined vaporized amount of the agent; the system further includes a controller in communication with the inhaler device, configured to control the pre-determined vaporized amount based on data indicative of at least one pharmacodynamic effect induced by the agent in the subject.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: December 12, 2017
    Assignee: Syqe Medical Ltd.
    Inventors: Perry Davidson, Shlomo Almog, Seth Kindler
  • Patent number: 9827384
    Abstract: A nebulizer is proposed which comprises a replaceable container containing fluid, a housing part detachable from the nebulizer for replacing the container, and an operation counter inseparable from the housing part as depicted in exemplary FIG. 10. The operation counter comprises a lead screw and an associated rider both supported by the housing part.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: November 28, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Holger Holakovsky, Ralf Thoemmes, Marc Rohrschneider, Florian Witte, Kevin Peter Deane, Douglas Ivan Jennings
  • Patent number: 9808588
    Abstract: An oscillating positive respiratory pressure apparatus and a method of performing oscillating positive respiratory pressure therapy. The apparatus includes a housing having an interior chamber, a chamber inlet, a chamber outlet, an exhalation flow path defined between the inlet and the outlet, and a restrictor member rotatably mounted within the interior chamber. The restrictor member has an axis of rotation that is substantially perpendicular to the flow path at the inlet, and includes at least one blocking segment. Rotation of the restrictor member moves the at least one blocking segment between an open position and a closed position. Respiratory pressure at the chamber inlet oscillates between a minimum when the at least one blocking segment is in the open position and a maximum when the at least one blocking segment is in the closed position. By exhaling into the apparatus, oscillating positive expiratory pressure therapy is administered.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: November 7, 2017
    Inventors: Adam Meyer, Dan Engelbreth
  • Patent number: 9795748
    Abstract: A delivery device is provided which comprises a container containing a dose of a powder and having at least one exit orifice for dispensing the dose from the container and a chamber adapted to receive the container in an operative configuration. The device further comprises at least one gas inlet by which gas may enter the chamber and at least one gas outlet by which gas and entrained powder may exit the chamber. The delivery device is operable to generate a gas flow through the chamber between the at least one gas inlet and the at least one gas outlet, which brings about orbital motion of the container within the chamber in that at least a central region of the container orbits a central axis of the chamber. The volume occupied by the container is at least 25% of the volume of the chamber.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: October 24, 2017
    Assignee: Pharmaxis Ltd.
    Inventors: Philip Seeney, Douglas Ivan Jennings
  • Patent number: 9795625
    Abstract: The present invention relates to the new indications of chronic obstructive pulmonary disease (COPD) and idiophathic lung fibrosis (IPF) for uridine and uridine analogs.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: October 24, 2017
    Assignee: Universitaetsklinikum Freiburg
    Inventors: Marco Idzko, Stephan Sorichter
  • Patent number: 9776145
    Abstract: Provided is a method of mixing first and second liquids having mutual solubility inside a mixing flow channel formed by a micro flow channel. This method includes: causing the first and second liquids to be joined to each other inside the mixing flow channel; and forming a slug flow, in which mixing subject cells (60) formed by the joined liquid and insoluble fluid cells (63) formed by an insoluble fluid are alternately arranged, inside a flow channel at the downstream side of an insoluble fluid supply position in a manner such that the insoluble fluid having insolubility with respect to both mixing subject liquids is supplied to the joined liquid flowing through the flow channel in a direction intersecting the flow channel so that the joined liquid is divided with a gap therebetween, thereby mixing the first mixing subject liquid and the second mixing subject liquid contained in each mixing subject cell inside the downstream flow channel.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: October 3, 2017
    Assignee: Kobe Steel, Ltd.
    Inventors: Daisuke Nishikawa, Takeshi Yamashita, Makoto Nishimura, Koji Noishiki
  • Patent number: 9776362
    Abstract: An additive manufacturing system is provided. The system includes: a stage, a powder supplying device, an energy beam generating device and an atmosphere controlling module. The powder supplying device provides powder to the stage. The energy beam-generating device generates an energy beam and directs the energy beam to the stage. The atmosphere controlling module includes at least one pair of gas inlet-outlet devices coupled around the stage, and a dynamic gas flow controlling device connected with the gas inlet-outlet devices. The dynamic gas flow controlling device dynamically controls an angle between a flow direction of the gas and a moving direction of the energy beam. The angle is predetermined by a scanning strategy.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: October 3, 2017
    Assignee: Industrial Technology Research Institute
    Inventors: Chuan-Sheng Chuang, Ching-Chih Lin, Wei-Chin Huang, De-Yau Lin
  • Patent number: 9778150
    Abstract: A method of obtaining a sample of materials includes building a product through an additive manufacturing process. A capsule is formed with an internal chamber inside of the capsule. The capsule is formed during the building of the additive manufacturing product. A sample of powder is encapsulated inside the internal chamber as the capsule is built. The internal chamber is hermetically sealed from an exterior environment to retain the sample of powder in the internal chamber.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: October 3, 2017
    Assignee: United Technologies Corporation
    Inventor: Christopher F. O'Neill
  • Patent number: 9764103
    Abstract: An inhaler/puffer is provided. The inhaler/puffer may comprise a body, a cap, and a base, the cap and the base being configured to functionally engage the body. The body may define a chamber wherein minerals, such as salt, may be housed. The body, cap, and base may be configured to permit a user to inhale on the cap and draw air through the base into the chamber, over the minerals, through the cap and into the respiratory system of the user. Additionally, the inhaler/puffer may be placed in-line with an oxygen breathing system, such that as the breathing system provides oxygen to the user, the user also receives salt air treatment.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: September 19, 2017
    Inventors: Lily A. Neff, Edward J. Neff
  • Patent number: 9757750
    Abstract: The invention relates to a hand-held medicinal device, particularly a nebulizer, for delivering a liquid medicament preparation from a container having a container cap. The medicament preparation may be based for example on an alcoholic solvent or may contain a similar substance with an increased vapor pressure. The proposed nebulizer with the installed container comprises a sealing system made up of two seals at the junction between the device and container, which prevent loss of liquid, diffusion leaks and exchange of gases with the environment at this point.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: September 12, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Holger Holakovsky, Lars Lange, Maurice Steinzen, Felix Weiland, Klaus List
  • Patent number: 9744318
    Abstract: A powder aerosolization apparatus comprises a housing comprising an outlet adapted to be inserted into a user's mouth and one or more bypass air openings. A receptacle support within the housing supports a receptacle containing a powder pharmaceutical formulation. A puncturing mechanism within the housing creates in the receptacle one or more inlet openings and one or more powder outflow openings, wherein the powder outflow openings have a total area of from 0.2 mm2 to 4.0 mm2. Upon a user's inhalation through the outlet, air flows through the one or more bypass air openings and through the receptacle to aerosolize the powder pharmaceutical formulation in the receptacle. In one version, the relative flow parameters between the flow through the one or more bypass openings and the one or more powder outflow openings are selected so that flow of aerosolized pharmaceutical formulation does not occur until a predetermined inhalation flow rate is achieved.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: August 29, 2017
    Assignee: Novartis AG
    Inventors: Leo Chan, Keith Try Ung, Jeffry G. Weers