Particulate Treating Agent Carried By Breathed Gas Patents (Class 128/203.15)
  • Patent number: 10814077
    Abstract: A substance delivery module and apparatus for delivering substance in aerosol form are disclosed. The substance delivery module includes a plurality of substance containers and a plurality of pistons, with each substance container being mounted in the module for cooperation with a dedicated piston. Another substance delivery module is disclosed that includes a piston defining a delivery axis and a substance container, moveably mounted with respect to the piston. The substance container is moveable along the delivery axis and may, for example, be moved toward and onto the piston. Either of the substance delivery modules may be assembled with an aerosol generator and an aerosol delivery conduit in fluid communication with the aerosol generator to form an apparatus for delivering substance in aerosol form. The apparatus may further include a control module.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: October 27, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Anthony Dyche, Ian Thomas Petherbridge
  • Patent number: 10806876
    Abstract: A positive exhalation pressure device (1) is described. The device (1) comprises a housing (2) having an annular chamber (5), a chamber inlet (6) configured to permit air into the chamber, a chamber outlet (7) configured to permit air out of the chamber, and a mouthpiece (8) in fluid communication with the chamber inlet. A movable body such as a ball (3) is disposed in the housing within the annular chamber and configured to revolve around the annular chamber in response to flow of air through the chamber from the chamber inlet to the chamber outlet. The movable body is configured to at least partially block the chamber outlet as it revolves around the annular chamber causing cyclical fluctuations in airflow resistance.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 20, 2020
    Assignee: Solopep Limited
    Inventors: Kevin J. O'Sullivan, Leonard W. O'Sullivan, Colum Dunne, Barry Linnane, Deirdre McGrath
  • Patent number: 10806872
    Abstract: The present disclosure relates to a dose indicator comprising, a chassis comprising a chassis frame and a displacement portion comprising a drive part to engage an indexable first display unit indexable about a first display axis, the indexable first display unit comprising a drive tooth to drive an indexable second display unit indexable about a second display axis, the second display axis being non-coaxial with the first display axis, the indexable second display unit comprising two or more second display unit indexing teeth, wherein the drive tooth and each of the second display unit indexing teeth comprise lips on their respective engagement surfaces, the drive tooth lip and second display unit indexing tooth lip each being adapted to engage at an engagement angle that produces a resultant force acting to pull the first display unit and second display unit together. The present disclosure further relates to an actuator for an inhaler, wherein the actuator comprises a dose indicator as described above.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: October 20, 2020
    Assignee: KINDEVA DRUG DELIVERY L.P.
    Inventor: Stephen J. Howgill
  • Patent number: 10792444
    Abstract: A dose indicator or dose counter is disclosed which includes an indexable first display unit indexable about a first display axis, an indexable second display unit indexable about a second display axis, the second display axis being transverse to the first display axis, and a chassis comprising a chassis frame, a displacement portion comprising a drive means to engage the first display unit, and at least one hinge means directly or indirectly connecting the displacement portion and chassis frame. The drive means is preferably configured to index the dose indicator. The dose indicator/counter has a small number of components yet is effective, reliable and compact.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: October 6, 2020
    Assignee: Kindeva Drug Delivery L.P.
    Inventors: Adam J Stuart, Stephen J Howgill
  • Patent number: 10786637
    Abstract: A delivery device is provided having a container containing a dose of greater than 40 mg of a powder and having at least one exit orifice for dispensing the dose from the container, a chamber adapted to receive the container in an operative configuration, at least one gas inlet by which gas may enter the chamber and at least one gas outlet by which gas and entrained powder may exit the chamber. The delivery device is operable to generate a gas flow through the chamber between the at least one gas inlet and the at least one gas outlet, which brings about orbital motion of the container within the chamber in that at least a central region of the container orbits a central axis of the chamber.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: September 29, 2020
    Assignee: Pharmaxis Ltd.
    Inventors: Philip Seeney, Douglas Ivan Jennings
  • Patent number: 10786456
    Abstract: A stable dry powder composition for inhalation includes acetylsalicylic acid in particles having a mass median aerodynamic diameter (MMAD) in a range of about 1 ?m to about 5 ?m. The dry powder composition may contain a pharmaceutically acceptable excipient, such as a stearate, in an amount ranging from about 0.04% (w/w) to about 0.06% (w/w), or from about 0.4% (w/w) to about 0.6% (w/w), of the composition.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: September 29, 2020
    Assignee: OTITOPIC INC.
    Inventor: Kambiz Yadidi
  • Patent number: 10772832
    Abstract: A respirable dry powder including acetylsalicylic acid in particles has a mass median aerodynamic diameter (MMAD) within a range of about 0.5 ?m to about 10 ?m. The respirable dry powder may contain a pharmaceutically acceptable excipient, such as a phospholipid, in an amount ranging from about 0.1% (w/w) to about 10% (w/w) of the particles.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: September 15, 2020
    Assignee: OTITOPIC INC.
    Inventor: Kambiz Yadidi
  • Patent number: 10773034
    Abstract: The present invention relates to an inhaler device for delivering a dose of medicament in dry powder form from a container to a patient in need thereof. The inhaler comprises first and second airflow paths (80, 85) which are arranged such that during inhalation, a capsule (40) having a longitudinal axis and first and second end sections (90, 95) delimiting the capsule on opposing ends located in a capsule chamber (30) performs an oscillating movement in the capsule chamber parallel to its longitudinal axis between first and second sidewall portions (60, 65) of the capsule chamber.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 15, 2020
    Assignee: Presspart Manufacturing Ltd.
    Inventors: Julian Hemy, Richard Turner, Hans-Peter Schmelzer, Hans-Jürgen Neugebauer, Dietmar Schmitz, Stefan Hoffmann, Ameet Sule, Sunita Sule, Matthias Seiler, George Alexander Bostock, Aki Hannu Einari Laakso, Michael Worth
  • Patent number: 10765602
    Abstract: The present disclosure relates to a medication delivery system including a medication administration device, a medication within the medication administration device, a container defining a cavity receiving the medication administration device, and a cap attached to the container and sealing the medication administration device within the cavity. The medication administration device includes an actuator extending from a body and operable to expel the medication by depressing the actuator into the body. The cap includes hold down members positioned to bear against the body of the medication administration device to prevent movement of the medication administration device toward the cap beyond a predetermined distance. The medication administration device is thereby prevented, inter alia, from prematurely discharging the medication during storage and transport.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: September 8, 2020
    Assignee: Eli Lilly and Company
    Inventors: Jaime Ray Arnett, Andrew Thomas Snow
  • Patent number: 10751488
    Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: August 25, 2020
    Assignee: MannKind Corporation
    Inventors: Chad C. Smutney, P. Spencer Kinsey, Carl R. Sahi, Benoit Adamo, John M. Polidoro
  • Patent number: 10736352
    Abstract: A smoking-pipe includes a pipe body, a cylinder, and a cylinder cover. The cylinder includes a plurality of smoking-chambers which may hold a reserve of combustible material for smoking. The cylinder may be positioned selectively to allow one smoking chamber at a time to be combusted, effectively providing a pipe which may be smoked through multiple sessions without requiring continual repacking.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: August 11, 2020
    Inventor: Ryan Eckhoff
  • Patent number: 10737042
    Abstract: A thermally modulating inhalable medicament delivery device may deliver an inhalable medicament as an aerosol, vapor, or partial aerosol and partial vapor mixture. The inhalable medicament may be delivered to a target in a subject. Described herein are devices, systems, and methods for delivering an inhalable medicament to a subject.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: August 11, 2020
    Inventor: Michael Edward Breede
  • Patent number: 10729862
    Abstract: A device (20) is disclosed for dispensing a fluid supplied from an external fluid source. The device comprises a transducer (32) adapted to receive a fluid from the fluid source, and a collapsible linkage and trip link (502) coupling the transducer and the fluid source. The linkage has a collapsible joint inhibiting discharge of the fluid source when in a locked orientation. The device (20) further comprises a moveable member coupled to the linkage such that inhalation forces on the device cause the linkage to collapse thereby discharging the fluid from the fluid source. The device may further include a dose counter coupled to the fluid source for registering the amount of doses administered from the fluid source.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: August 4, 2020
    Assignee: CIPLA (EU) LIMITED
    Inventors: Frank Pieters, Xerxes Rao
  • Patent number: 10722666
    Abstract: A nebulizer includes a replaceable container with fluid to be nebulized. The container includes an inseparable indicator device. The container and the indicator device are axially moved during nebulization and tensioning of the nebulizer. The indicator device controls locking of the nebulizer against further use if a predetermined number of uses has been reached or exceeded.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: July 28, 2020
    Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Joachim Eicher, Markus Mueller, Robert Gerhard Winkler
  • Patent number: 10716904
    Abstract: The present invention provides in part dry powder inhaler (DPI) devices for dispensing dry powder and methods for using the same. The DPI devices feature exchangeable cartridges having drum mechanisms that prepare metered doses of dry powder, and are able to direct air in a turbulent manner sufficient to entrain and deagglomerate a dose of dry powder for delivery into a user's lungs. The DPI devices feature a reservoir of dry powder advanced by a plunger, as well as a gauge that advances with the plunger to indicate the amount of dry powder remaining in the reservoir.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: July 21, 2020
    Assignee: Philip Morris Products S.A.
    Inventors: James Tibbatts, Robin Craig Cocker, Ben Alexander King, Christopher Iain Davidson, Paul Mutti, Alex Stenzler, Steve Han
  • Patent number: 10682476
    Abstract: A dry powder inhaler includes a powder storage element configured to hold a powdered medicament and an inlet channel receives powdered medicament from the powder storage element that is entrained in an airflow. The inlet channel has a first diameter and defines an opening. The inhaler includes a dispersion chamber that receives the airflow and the powdered medicament from the opening. The dispersion chamber has a second diameter. The inhaler includes an actuator housed within the dispersion chamber. The actuator oscillates within the dispersion chamber when exposed to the airflow to deaggregate the powdered medicament entrained by the airflow passing through the dispersion chamber. A ratio between the first diameter and the second diameter is between about 0.40 and 0.60 such that an audible sound is produced as the actuator oscillates. The inhaler includes an outlet channel through which the airflow and powdered medicament exit the inhaler.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: June 16, 2020
    Assignee: Respira Therapeutics, Inc.
    Inventors: Robert M. Curtis, Dan Deaton, James Hannon, Hugh Smyth, Zhen Xu, Martin J. Donovan
  • Patent number: 10668231
    Abstract: The present invention discloses a device useful for facilitating delivery of drugs or medicaments to the respiratory system of a user. The device comprising a mechanism for interrupting the airflow during inhalation or exhalation performed by the user through the device by generating pressure pulses within the respiratory system of the user, such that the delivery of the drugs to the user is facilitated; the pressure pulses are selected from the group consisting of: inspiratory Negative Pressure (NP) pulses, inspiratory Positive Pressure (PP) pulses, expiratory Negative Pressure (NP) pulses, expiratory Positive Pressure (PP) pulses into the respiratory system, and any combination thereof.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: June 2, 2020
    Assignee: RESPINOVA LTD.
    Inventor: Yuval Avni
  • Patent number: 10668230
    Abstract: A nebulizer and a method of breathing using the nebulizer is described. The nebulizer and breathing techniques are capable of delivering medicament into the sinus cavity of a user.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: June 2, 2020
    Assignee: Kurve Technology, Inc.
    Inventor: Marc Giroux
  • Patent number: 10639437
    Abstract: A delivery device for and method of delivering a metered amount of substance, the delivery device comprising: a mouthpiece through which a user in use exhales; an outlet through which substance is in use delivered; a housing fluidly connected to the mouthpiece and the outlet, such that exhalation by the user through the mouthpiece creates an air flow through the housing and from the outlet; and a substance-dispensing unit which is disposed within the housing and operative to dispense a metered amount of substance into an entraining air flow as created through the housing.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: May 5, 2020
    Assignee: OptiNose AS
    Inventors: Per Gisle Djupesland, Rune Harald Gaarder, Sébastien Lamolle
  • Patent number: 10639440
    Abstract: An automated drug delivery and monitoring system for use on mechanically ventilated patients in the intensive care unit is presented. Medication in the form of respirable particles is transported through ventilator circuitry by a delivery unit. Multiple medications may be delivered into the gas flow of the ventilator, with each medication delivered in a defined dose for a frequency and interval as specified by an operator. The particles mixed into the gas flow of the ventilator are inhaled and ingested by the patent's lungs.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: May 5, 2020
    Assignee: iDTx Systems, Inc.
    Inventor: Michael Spandorfer
  • Patent number: 10632268
    Abstract: The integration of drug dispersion methods into a drug or medicine delivery system may use shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The integration of a drug sealing system into the device provides a way of blocking the migration of drug from one area of the package to another. The drug seal system can also provide a method of tightly containing the drug until the package is opened, of directing airflow through the package and of managing and containing the drug during the package/device manufacturing process.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: April 28, 2020
    Assignee: Manta Devices, LLC
    Inventors: Andrew Jones, Richard L. Miller
  • Patent number: 10583261
    Abstract: Provided is an inhaler for halotherapy having in an axial direction a proximal end for insertion into the mouth of a user, and a distal end opposite to the proximal end, wherein the inhaler comprises an inlet, an outlet arranged at the proximal end, an air passage extending from the inlet to the outlet, and a reservoir communicating with the air passage through a release orifice, the reservoir containing a dispersible substance.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: March 10, 2020
    Assignee: Liita Holdings LTD
    Inventors: Martin Ohrt, Jeppe Paustian, Søren Dyring Jensen
  • Patent number: 10561809
    Abstract: A breath actuated dry powder inhaler with a single air circulation chamber for de-agglomeration of entrained powdered medicament using the energy of the inspiratory air stream. The chamber has a substantially polygonal sidewall, a plurality of air supply channels entering the chamber substantially tangentially to its sidewall. A powder channel extends through a powder dose supply region of the inhaler tangentially into the chamber. An air outlet axially extends from a discharge and connects to a discharge channel that extends to a mouthpiece. The polygonal sidewall comprises at least six straight line segments, each straight line segments being spaced at the same first distance from an adjacent one forming the plurality of air supply channels. The air supply channels have the same width. The powder channel is defined by two straight line segments which are spaced from each other at a second distance which is larger than the first distance.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: February 18, 2020
    Assignee: Rijksuniversiteit Groningen
    Inventors: Anne Haaije de Boer, Paul Hagedoorn, Henderik Willem Frijlink
  • Patent number: 10556069
    Abstract: An inhaler device comprising: a housing (2), a base plate (4) covering the housing (2), a medicament holder (10) integrated with the base plate (4), a mouthpiece (3) sitting over the base plate (4), a lid (1) which covers the mouthpiece (3), at least one piercing element (11), an actuating member (5), a spring (12), and is characterized in that the inhaler device is a two hinges system (6,8) wherein the base plate (4) is joined to hinge (6); the mouthpiece (3) and the lid (1) are joined to the hinge (8).
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: February 11, 2020
    Assignee: LUPIN LIMITED
    Inventors: Vishwajit Bhide, Raghuram Amperayani Pattabhi, Rohini Pimple, Bishu Choubey
  • Patent number: 10525216
    Abstract: A dry powder inhaler includes a powder storage element configured to hold a powdered medicament and an inlet channel receives powdered medicament from the powder storage element that is entrained in an airflow. The inlet channel has a first diameter and defines an opening. The inhaler includes a dispersion chamber that receives the airflow and the powdered medicament from the opening. The dispersion chamber has a second diameter. The inhaler includes an actuator housed within the dispersion chamber. The actuator oscillates within the dispersion chamber when exposed to the airflow to deaggregate the powdered medicament entrained by the airflow passing through the dispersion chamber. A ratio between the first diameter and the second diameter is between about 0.40 and 0.60 such that an audible sound is produced as the actuator oscillates. The inhaler includes an outlet channel through which the airflow and powdered medicament exit the inhaler.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: January 7, 2020
    Assignee: Respira Therapeutics, Inc.
    Inventors: Robert M. Curtis, Dan Deaton, James Hannon, Hugh Smyth, Zhen Xu, Martin Donovan, Aileen Gibbons
  • Patent number: 10525218
    Abstract: A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject. The delivery device includes a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject. The body assembly is configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: January 7, 2020
    Assignee: OptiNose AS
    Inventors: Per Gisle Djupesland, Colin David Sheldrake, Simon Smith, Rachel Striebig, Andy Pidgeon, Tom St. Quintin
  • Patent number: 10525240
    Abstract: A device, a system and a method are provided to accurately apply a medically beneficial substance directly to a laterally or superiorly located paranasal sinus cavity. When the device is assembled with a solution in a reservoir, and inverted such that the reservoir is above an input apparatus and a housing, weight of the solution pushes down on a diaphragm creating a negative pressure on the diaphragm, which prevents air from entering the reservoir and prevents a liquid from flowing out of the reservoir. Applying a positive pressure to a bottom of the diaphragm causes the diaphragm to open and allows air to flow into the reservoir. When a user creates the positive pressure by exhaling air into the device the act of exhaling causes the user's choana to close. Thereby any solution introduced into the user's sino-nasal cavity will remain contained within the user's sino-nasal cavity increasing effectiveness of treatment and decreasing user discomfort including gagging, choking, and inner ear disturbance.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: January 7, 2020
    Assignee: Sandler Scientific LLC
    Inventors: Stephen W. Chandler, David W. Sanso
  • Patent number: 10507295
    Abstract: A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: December 17, 2019
    Assignee: Impel Neuropharma, Inc.
    Inventors: John D. Hoekman, Michael Hite, Alan Brunelle, Joel Relethford, Rodney J. Y. Ho
  • Patent number: 10507293
    Abstract: The present invention is directed to a device for the expression of a hemostatic powder having an elongated reservoir with a manual air pump, such as a bellows, at a proximal end and an expression port at a distal end. A porous filter is slidably disposed within the reservoir between the bellows and plunger and the expression port, and a spring is disposed within the reservoir between the air pump and the plunger. The powder is disposed within the reservoir between the porous filter and the expression port, and the pump is in a fluid communication with the expression port through the porous filter and through the powder.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: December 17, 2019
    Assignee: Ethicon, Inc.
    Inventors: John Goodman, Alex W. Kiturkes, Jared Schneider
  • Patent number: 10488425
    Abstract: An assay cartridge has a base member (26) that defines at least two wells (30, 32, 34, 36, 38), a pipette (108, 110) positionable in at least one of the wells and a cap member (86) arranged to carry the pipette. The cap member can be releasably fastened to the base member. An extension member (28) defines at least one further well (40, 42, 44) and can be fastened to the base member such that the pipette is then positionable in at least one of the wells of the base and in the further well of the extension member.
    Type: Grant
    Filed: November 19, 2017
    Date of Patent: November 26, 2019
    Assignee: AXIS-SHIELD AS
    Inventors: Lars Ørning, Frank Frantzen, Andrew Thomas Campbell, Arve Strømsheim
  • Patent number: 10478572
    Abstract: A dry powder inhaler for pulmonary or nasal use, comprising at least an inhaler body 801 and a cartridge 803 with at least one powder compartment 805 including one dose of a drug. The body has an opening 804 shaped for receiving the cartridge 803 and the means to allow a controlled sliding movement of the cartridge 803 relative to the body 801 after mounting. The cartridge powder compartment 805 comprises at least two inlets or slits 806, 809, at least one of which is a side inlet 809, for the admission of air, and a compartment outlet 807 to allow filling and fluid communication with an inhalation channel 808 provided in the body 801.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: November 19, 2019
    Assignee: Hovione Technology Ltd.
    Inventors: João Ventura, Peter Villax
  • Patent number: 10478573
    Abstract: A counter for a handheld device for dispensing a pharmaceutical substance includes at least one counter wheel having legible characters. The counter wheel is rotatable about a rotational axis, and a drive part having a shaped engagement section rotates the counter wheel. An acting part, displaceable relative to the counter wheel in the direction of extension of the rotational axis against a spring force, is connected to and rotates together with the drive part. A base part which can form a part of the housing and can be inserted into the housing at least partly overlaps the substance container in the direction of the longitudinal axis of the substance container, and has a stationary rotational axis for the counter wheel, the drive part preferably being guided in the rotational axis. The drive part is located on the side of the substance container with respect to the counter wheel.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: November 19, 2019
    Inventor: Alfred Von Schuckmann
  • Patent number: 10478574
    Abstract: A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit (17) for insertion into a nasal airway (1) of a subject and comprising an outlet unit (21) which includes a nozzle (25) for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle: wherein the delivery device is configured such that at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: November 19, 2019
    Assignee: OptiNose AS
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner
  • Patent number: 10463815
    Abstract: A dry powder inhaler may include a powder storage region, an inlet channel, a dispersion chamber, and an outlet channel. A geometry of the inhaler may be such that a flow profile is generated within the dispersion chamber that causes an actuator to oscillate, enabling the actuator when oscillating to deaggregate powdered medicament within the dispersion chamber to be aerosolized and entrained by the air and delivered to a patient through the outlet channel.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: November 5, 2019
    Assignee: RESPIRA THERAPEUTICS, INC.
    Inventors: Robert M. Curtis, Martin J. Donovan, Hugh Smyth
  • Patent number: 10456535
    Abstract: The present invention relates to an inhaler device for delivering a dose of medicament in dry powder form from a container to a patient in need thereof. The inhaler comprises a swirl chamber in which particles of the medicament entrained in an airflow swirl upon inhalation thereby breaking up the agglomerates into finest dispersed powder.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: October 29, 2019
    Assignee: Presspart Manufacturing Ltd.
    Inventors: Julian Hemy, Richard Turner, Hans-Peter Schmelzer, Dietmar Schmitz, Stefan Hoffmann, Ameet Sule, Sunita Sule, Matthias Seiler, George Alexander Bostock, Aki Hannu Einari Laakso, Michael Worth, Matthew Schumann
  • Patent number: 10434268
    Abstract: The invention relates to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient, said activating device being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when pressed by the patient.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: October 8, 2019
    Assignee: ASTRAZENECA AB
    Inventors: Martin Herder, Gerhard Ludanek, Ingo Mett, Joachim Schmidt
  • Patent number: 10413604
    Abstract: The invention is directed to an oral vaccine composed of a micronized freeze-dried rotavirus particle emulsion with buffering excipients in a non-aqueous liquid. This IVT-06 formulation has imparted heat stability by protecting the virus at temperatures of 30° C. and 40° C. for at least twelve months. Extrapolations from the 12-month stability data indicate a shelf life of more than two years at 30° C., and six months at 50° C. In addition, for ease of administration, the formulated dose has a volume of 0.5 mL.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: September 17, 2019
    Assignee: Inventprise, LLC
    Inventors: Subhash V. Kapre, Ivan A. Olave
  • Patent number: 10412995
    Abstract: An e-vapor device may include a housing shell configured to receive a supply packet containing a pre-vapor formulation, a mouthpiece secured to an end of the housing shell, a puncture device within the housing shell, and a heater structure within the housing shell and arranged to be in thermal contact with the pre-vapor formulation. The mouthpiece is configured to transition from a protracted position to a retracted position. The puncture device is configured to pierce the supply packet to release the pre-vapor formulation when the mouthpiece transitions to the retracted position. The heater structure is configured to vaporize the pre-vapor formulation to generate a vapor.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: September 17, 2019
    Assignee: Altria Client Services LLC
    Inventor: Jason Andrew Macko
  • Patent number: 10413675
    Abstract: The disclosure provides a supplemental device configured for removable attachment to a medicament injection device. The supplemental device includes a display, a processor arrangement, at least one memory, and an image-capturing component. The processor arrangement is configured to cause the supplemental device to: (i) use the image capturing component to capture successive images of a medicament dosage indicated by a medicament dispensing device, (ii) successively display the captured images on the display, (iii) perform optical character recognition on captured images to identify medicament dosage indicated by the medicament dispensing device when the images were captured, (iv) and make a non-transient record of delivered dosage information in the at least one memory based at least in part on the identified medicament dosage.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: September 17, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Christoph Gugl, Johannes Eckstein, Adrian Geiger, Philipp Muller
  • Patent number: 10398859
    Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a p
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: September 3, 2019
    Assignee: OptiNose AS
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
  • Patent number: 10384027
    Abstract: A semi-malleable nasal mask system which includes an internal support structure for providing a uniform-like sealing force around the user's nose and nose area.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: August 20, 2019
    Assignee: Breas Medical, Inc.
    Inventor: Donald Harrison
  • Patent number: 10376660
    Abstract: Taught herein is a disposable breath actuated dry powder drug inhalation device having a powderized drug storage chamber with integral toroidal geometry and air flow pathways for entraining and breaking up powder aggregates prior to delivery to the patient. The toroidal chamber is fluidly connected by one or more air inlets directed in a non-tangent manner toward the powder to loft and set up an irregular-rotational flow pattern. Also, in fluid connection with the toroidal chamber is a centrally or near centrally located air and powder outlet consisting of one or more holes forming a grid in fluid connection with a channel providing a passageway for powder flow to the patient.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: August 13, 2019
    Assignee: Concentrx Pharmaceuticals, Inc.
    Inventor: Eric Carl Richardson
  • Patent number: 10375991
    Abstract: An electronic inhalation device includes an outer housing extending in a longitudinal direction, an air inlet, an outlet, a formulation, and an abrasive element, which contacts a surface of the formulation. The abrasive element is configured to generate a particle cloud from the formulation by removing particles from the formulation and entraining the particles in an air flow.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: August 13, 2019
    Assignee: Altria Client Services LLC
    Inventor: Peter Lipowicz
  • Patent number: 10376661
    Abstract: An opening element for opening an ampoule in an aerosol generation device includes a first member which has a conduit extending therethrough for guiding a fluid contained in the ampoule through the first member and a second member which is arranged at least partly inside or on the conduit. Further, an aerosol generation device includes such an opening element.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: August 13, 2019
    Assignee: PARI Pharma GmbH
    Inventors: Thomas Gallem, Uwe Hetzer, Stephen Pham, Reynaldo Quintana
  • Patent number: 10349677
    Abstract: There is provided an aerosol generating system, the system comprising: aerosol generating means; aerosol delivery means; and an aerosol guiding device. The aerosol guiding device (1) comprises a chamber (10) having an air inlet (11) and an air outlet (12), the aerosol delivery means is configured such that aerosol is introduced from the aerosol generating means into the chamber in use at its narrowest part (13), and an airflow route is defined from the air inlet to the air outlet so as to convey the aerosol to the air outlet. There is also provided an aerosol guiding device for use in an aerosol generating system, the device comprising: a chamber having an air inlet and an air outlet. Aerosol is introduced from an aerosol generating means into the chamber in use at its narrowest part, and an airflow route is defined from the air inlet to the air outlet so as to convey the aerosol to the air outlet.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: July 16, 2019
    Assignee: JT International S.A.
    Inventor: Andrew Robert John Rogan
  • Patent number: 10344055
    Abstract: Described is a composition comprising—a peptide which consists of 7-17 adjacent amino acids and comprises the hexamer TX1EX2X3E, where X1, X2 and X3 can be any natural or non-natural amino acid, and the peptide is cyclized and does not exhibit TNF receptor binding activity, and—an inhibitor of viral neuraminidase.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: July 9, 2019
    Assignee: Apeptico Forschung UND Entwicklung GMBH
    Inventors: Bernhard Fischer, Rudolf Lucas, Hendrik Fischer
  • Patent number: 10342937
    Abstract: A fluid dispenser device including a body and a cover that pivots between a closed position and an open position and reservoirs each containing a dose of fluid. The reservoirs are arranged on a strip and an opening mechanism is provided. The device includes a movable support to move a reservoir against the opening mechanism. The movable support is movable between a non-dispensing position and a dispensing position. The device includes a strip-rolling system having a drum and an actuator member. The actuator member turning relative to the body in a first direction when the movable support is moved from the non-dispensing position towards the dispensing position, and in a second direction when the movable support is moved from their dispensing position towards the non-dispensing position. The actuator member causes the drum to turn only when turning in the second turning direction.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: July 9, 2019
    Assignee: APTAR FRANCE SAS
    Inventors: Arnaud Colomb, Maxime Kirniak
  • Patent number: 10335558
    Abstract: Embodiments disclosed herein are directed to methods, compositions and apparatus for administering active agents to the lungs of a subject.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: July 2, 2019
    Assignee: PARION SCIENCES, INC.
    Inventors: Richard C. Boucher, Michael Ross Johnson, William R. Thelin, Brian Button, Tomas Navratil
  • Patent number: 10300228
    Abstract: A thermally modulating inhalable medicament delivery device may deliver an inhalable medicament as an aerosol, vapor, or partial aerosol and partial vapor mixture. The inhalable medicament may be delivered to a target in a subject. Described herein are devices, systems, and methods for delivering an inhalable medicament to a subject.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: May 28, 2019
    Inventor: Noah Mark Minskoff
  • Patent number: 10286164
    Abstract: A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: May 14, 2019
    Assignee: OptiNose AS
    Inventor: Per Gisle Djupesland