Particulate Treating Agent Carried By Breathed Gas Patents (Class 128/203.15)
  • Patent number: 11224704
    Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: January 18, 2022
    Assignee: MANTA DEVICES, LLC
    Inventors: Andrew Jones, Richard L. Miller
  • Patent number: 11224705
    Abstract: An inhaler for inhalation of a formulation in powder form includes: a magazine which is rotatable and contains pre-dosed doses of the formulation in capsules, a housing which is substantially round or disc-shaped, the housing having a housing part in which the rotatable magazine is disposed, where the housing part is fixedly coupled to the rotatable magazine, and is removable from the housing in order to facilitate replacement of the magazine by inserting a new magazine.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: January 18, 2022
    Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Holger Holakovsky, Jens Besseler, Jessica Frentzel-Beyme, Frank Herrmann
  • Patent number: 11185671
    Abstract: The present invention provides an apparatus for producing medical foam for wound care or hair stimulation. The apparatus includes a foam generation unit having a fluid reservoir, a fluid delivery line and a foam generation tip. The apparatus also includes a compressed gas unit having at least one container of compressed gas, a source of electric power, and a gas regulator valve. A supply of wound care or hair stimulating solution is communicably connected to the foam generation tip such that when the apparatus is operated medical foam is produced by the foam generator tip.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: November 30, 2021
    Inventor: Frank Levy
  • Patent number: 11179526
    Abstract: An inhaler for powdered medicaments is provided. It consists of a substantially smoking pipe-shaped hollow body that has a first portion, for housing a cartridge of powdered medicament, and a second portion for delivering the medicament by means of an airstream that carries the powder from an inner drop region along a delivery duct whose end is suitable to be placed in a patient's mouth, the intake of the air being achieved through at least three air intakes arranged symmetrically with respect to the longitudinal midplane of the inhaler, which includes a support base for the cartridge in which oriented flow channels are formed that extend between the three air intakes and the inner powder drop region.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 23, 2021
    Assignee: HOLLYCON ITALY PTE. LTD.—S.R.L.
    Inventors: Qi Wu, Huaxin Wu
  • Patent number: 11141545
    Abstract: A spray apparatus adapted to be connected to a fluid supply such as a syringe to spray a predetermined pattern of spray fluid to a target area such as the tissues of an animal or human. The sprayer delivers a predetermined dose of a medicament, vaccine or the like to the nasal or other cavity of an animal or human patient. The sprayer includes a base member and a cap member which is connected to the base member. The base member is connectible to the fluid supply. Spray is discharged from the distal or outward end of the cap member. The base member has a central, longitudinal lumen having a predetermined configuration. Fluid traverses the lumen and is discharged through a central aperture of the cap, which also has a predetermined configuration. The cap central lumen and spray discharge aperture are aligned with the base lumen.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: October 12, 2021
    Assignee: Mark L. Anderson, LLC
    Inventors: Mark L. Anderson, John Harmon, Brian Husby, Kevin O'Connell
  • Patent number: 11123289
    Abstract: The present invention relates to methods and compositions for treating lymphangioleiomyomatosis in a human subject in need of such treatment. The methods comprise administering to the subject via inhalation an aerosol composition comprising rapamycin or a prodrug or derivative (including analog) thereof.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: September 21, 2021
    Assignee: AI Therapeutics, Inc.
    Inventors: Henri Lichenstein, Jonathan M. Rothberg, Thomas Armer, Lawrence S. Melvin, Jr.
  • Patent number: 11110163
    Abstract: The invention is directed to an oral vaccine composed of a micronized freeze-dried rotavirus particle suspension with buffering excipients in a non-aqueous liquid. This IVT-06 formulation has imparted heat stability by protecting the virus at temperatures of 30° C. and 40° C. for at least twelve months. Extrapolations from the 12-month stability data indicate a shelf life of more than two years at 30° C., and six months at 50° C. In addition, for ease of administration, the formulated dose has a volume of 0.5 mL.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: September 7, 2021
    Assignee: Inventprise, LLC
    Inventors: Subhash V. Kapre, Ivan A. Olave
  • Patent number: 11105671
    Abstract: The present invention refers to a device for storage and dosage of a powder or a liquid, wherein the device comprises a removable top cap, an annular grip portion that encircles an upper part of a main container, which connects and locks to an outer container, which main container is arranged to store an amount of a powder or a liquid and the outer container encircles and connects the main container to a volume container, which volume container is used to adjust a dispensing volume of the device and has a removable bottom cap in its lower end through which the desired amount can be discharged. The invention further relates to the use of such a device.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: August 31, 2021
    Assignee: Doseramera AB
    Inventors: Magnus Jangsäter, Martin Carlsson
  • Patent number: 11103659
    Abstract: A dose delivery device with a mouthpiece having an inlet, an outlet, and an air path extending between the inlet and the outlet. A dose chamber having an opening may hold a dose, e.g., for inhalation by a user. One or more bypass inlets, two or more dispersion chambers, and/or flow arrangements in which incoming and outgoing flow in a dispersion chamber are transverse may be used to disperse a dose for delivery to a user.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: August 31, 2021
    Assignee: MANTA DEVICES, LLC
    Inventors: Andrew Jones, Richard L. Miller
  • Patent number: 11083858
    Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device including a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which the substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: August 10, 2021
    Assignee: OptiNose AS
    Inventors: Per Gisle Djupesland, Colin David Sheldrake
  • Patent number: 11076774
    Abstract: The present invention provides a patient inhalation/exhalation device such as a spirometer, respiratory inhaler or spacer, the device comprising: at least one aperture for inlet or outlet of air into/from the device; a mouthpiece for communication with the mouth of the patient; and a body defining an air flow path extending between the aperture and the mouthpiece along which air is drawn to the mouthpiece by inhalation by the patient or air is forced towards the aperture by exhalation by the patient. The body comprises an air flow rate indicator operable to generate a sound signal to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level. In another aspect, the present invention provides a device for indicating a desired fluid flow rate along a fluid flow path through a respiratory inhaler.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: August 3, 2021
    Assignee: CLEMENT CLARKE INTERNATIONAL LTD.
    Inventors: David Spencer, Ronald Bruin, Mark Sanders
  • Patent number: 11065410
    Abstract: A molded breathing appliance for supporting a nasal oxygen tube having an upper bite rim, a lower bite rim, a moldable material disposed within the upper bite rim and lower bite rim for conforming to a patient's maxillary bite impression and mandibular bite impression, respectively, an L-shaped member extending outwardly perpendicular to the upper bite rim, and a transverse support disposed on the L-shaped member and configured with a plurality of sets of oxygen tube finger clamps to retain a nasal oxygen tube in proximity with a patient's nostrils.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: July 20, 2021
    Inventor: Leonard Feld
  • Patent number: 11033917
    Abstract: Disclosed is a closable container of a mesh material having openings. When the container is closed, the openings are the only gaps in the container. The openings are no more than 150 microns in diameter.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: June 15, 2021
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventor: Scooter Johnson
  • Patent number: 11020547
    Abstract: A multi-dose dry powder inhaler with a blister folding device is provided. The inhaler comprises a housing containing a blister strip, and a blister opening device. The blister strip comprises a plurality of individual blisters, each blister containing a dose of medicament for inhalation by a user. The blister opening device comprising a blister support element for supporting one of said blisters, and a blister folding element co-operable with the blister support element, the blister folding element and the blister support element being movable relative to each other between a first position, permitting movement of said blister into or onto the blister support element, and a second, burst, position in which the blister folding element has co-operated with the blister support element.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: June 1, 2021
    Assignee: VECTURA DELIVERY DEVICES LIMITED
    Inventors: Peter Wilson, Roger Clarke, Liam McGuinness
  • Patent number: 11007322
    Abstract: In one aspect, the present disclosure relates to a sensor for measuring at least one physical or chemical parameter of a cartridge or syringe filled with a liquid substance. In further aspects the disclosure relates to a cartridge equipped with such a sensor and a drug delivery device equipped with such a cartridge. The sensor comprises a planar flexible foil arrangeable to an outer circumference of a barrel of the cartridge or syringe. The sensor also includes at least a first and a second measuring electrode is arranged on the foil and at least a first and a second contact electrode is arranged on the foil. The sensor further comprises, processor connected to the first and to the second measurement electrodes and a transceiver arranged on the foil. The transceiver is also and connected to the processor. Additionally, the first contact electrode and the second contact electrode are connected to the processor.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: May 18, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Schabbach, Christian Nessel, Daniel Auernhammer, Francisco Soares, Beate Franke
  • Patent number: 10967139
    Abstract: The present invention relates to an inhaler which comprises a durable unit and a replaceable (cartridge) unit, and which comprises systems, subsystems and elements to provide an “open-inhale-close” user experience. A durable unit comprises a breath-actuated trigger mechanism, and optionally electronics for providing user feedback, and telehealth can capability. A replaceable unit comprises a mouthpiece, blister strip, aerosol path dose counter and a blister piercing and aerosolization engine assembly assembly. A lockout mechanism may be provided to prevent further use of the cartridge when the dose counter reaches a preselected limit, such as zero.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: April 6, 2021
    Assignee: Novartis AG
    Inventors: Mark Glusker, Alex Yulan Chiao, George Axford, Colleen Patricia Serafin, Jonathan Patrick Summers, Jonathan Paul Downing
  • Patent number: 10960152
    Abstract: A capsule containing particles including nicotine wherein a single aperture extends through the capsule.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: March 30, 2021
    Assignee: Philip Morris Products S.A.
    Inventors: Gerard Zuber, Nicolo Volpe
  • Patent number: 10953164
    Abstract: A portable inhalation device includes a medication storage component, a flow controller, an atomizer, a medication delivery component, and a pressure sensor. The medication storage component is configured to store medication. The flow controller is configured to cause a force to be applied to the medication stored by the medication storage component to transport the medication to the atomizer. The atomizer is configured to generate droplets from the medication. The medication delivery component includes a delivery channel extending from the atomizer to an outlet opening. The medication delivery component is configured to receive the medication in the delivery channel from the atomizer and dispense the medication via the opening. The pressure sensor is configured to detect a pressure corresponding to a flow rate of air in the delivery channel and output an indication of the detected pressure.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: March 23, 2021
    Assignee: Argospire Medical Inc.
    Inventors: Terrence McGuckin, Kirsten Collier, Ashmit Gupta
  • Patent number: 10953165
    Abstract: A dry powder inhaler (10) having a chamber (26) divided into first and second blister compartments (28, 30) for storing unused and used portions (34, 36) of a blister strip (12) is provided. A moveable dividing wall (32) separates the first and second blister compartments. One or more arcuate supporting surfaces (38, 40, 42) are disposed in either the first and/or the second blister compartments and these surfaces support the used or unused blister strip during successive actuations of the inhaler. Use of the arcuate supporting surfaces facilities compact coils of unused and used portions of blister strip, thereby reducing the size of the chamber required for the inhaler.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: March 23, 2021
    Assignee: VECTURA DELIVERY DEVICES LIMITED
    Inventors: Andreas Meliniotis, Liam McGuinness
  • Patent number: 10952928
    Abstract: The present invention provides a depilling device for a blister package comprising at least one array of dosage forms to be dispensed, wherein each dosage form is contained within a blister formed as a covered cavity bounded by a backing, said device comprising a double action depilling mechanism, comprising a first pusher, sized and adapted to engage a top surface of said covered cavity and to exert a first sufficient force thereagainst so as to push said dosage form contained therein against its respective bounding backing, and a second pusher sized and adapted to more forcibly engage said top surface of said covered cavity and to exert a second sufficient force thereagainst so as to expel said dosage form from said blister.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: March 23, 2021
    Assignee: Dosentrix Ltd.
    Inventor: Ilan Paz
  • Patent number: 10950149
    Abstract: A dispenser includes a dispenser housing, an indicating device connected to the dispenser housing and a container removably engaged with the dispenser housing. The container and the dispenser housing remain connected as the container is moved between an engaged position and a disengaged position relative to the dispenser housing. The dispenser housing includes an upper portion pivotally connected to a lower portion.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: March 16, 2021
    Inventors: Greg Lawrence, Peter M. Scarrott
  • Patent number: 10926051
    Abstract: Embodiments disclosed herein relate to respiratory interfaces for use in treating various respiratory issues including, but not limited to, sleep disorder breathing (e.g. snoring, sleep apnea), and in other forms of assisted and unassisted respiration. Embodiments disclosed herein further relate to nasal prongs, flanges and valves for use with respiratory interfaces. Embodiments disclosed herein further relate to evaluating patient compliance with a respiratory interface and harvesting energy for the respiratory.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: February 23, 2021
    Assignee: InnoMed Healthscience, Inc.
    Inventors: Louis Javier Collazo, Angelo Caruso, Shara Hernandez, Bruce Sher
  • Patent number: 10912334
    Abstract: This disclosure relates to flavoured nicotine powder inhalers where the nicotine powder is delivered at air flow rates that mimic a smoking regime.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: February 9, 2021
    Assignee: Philip Morris Products S.A.
    Inventors: Ihar Nikolaevich Zinovik, Gerard Zuber
  • Patent number: 10906727
    Abstract: A squeeze container capable of preventing a clogging caused by a powdery content is provided. The squeeze container capable of discharging a powdery content to an outside of the squeeze container, the squeeze container having two tubes suspended down to the inside of a container body to serve as through holes of the powdery content, the tip of one tube of the two tubes is fixed to one hole formed on an upper surface of the cylindrical body, the tip of the other tube passes through the other hole formed on the upper surface of the cylindrical body and extends to an internal space of the cylindrical body, and a gap is formed between a bottom of the container body and the opening of the cylindrical body so that the powdery content can enter into the internal space of the cylindrical body.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: February 2, 2021
    Assignee: RUAN CO., LTD.
    Inventor: Tsuyoshi Mashima
  • Patent number: 10894134
    Abstract: A nebulizer is proposed which comprises a blocking device for blocking opening of the nebulizer in a tensioned state. The nebulizer comprises preferably an indicator device for indicating a tensioned state of the nebulizer. The nebulizer comprises further a depressible actuator member at a housing part which is detachable from the nebulizer.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: January 19, 2021
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jens Besseler, Frank Herrmann, Holger Holakovsky, Herbert Argauer, Josef Gatz, Andreas Gorshoefer
  • Patent number: 10888675
    Abstract: An inhaler including a magazine having capsules, a mouthpiece and a cover associated with the mouthpiece, where the cover is radially movable and pivotable for open or closing of the mouthpiece, by pivoting the cover the magazine is conveyed from one capsule to the next capsule, and by radial movement of the cover a capsule is moved in a radial direction into a discharge position.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: January 12, 2021
    Inventors: Holger Holakovsky, Jens Besseler, Jessica Frentzel-Beyme, Frank Herrmann, Markus Kaemper
  • Patent number: 10874139
    Abstract: An e-vapor device may include a capsule, a mouthpiece configured to receive the capsule, and a vaporizer configured to engage with the mouthpiece to enclose the capsule therebetween. The capsule is configured to hold a pre-vapor formulation therein. The vaporizer is configured to pierce the capsule to access the pre-vapor formulation therein and to heat the pre-vapor formulation to generate a vapor. Additionally, the vaporizer may be configured to cease a heating of the pre-vapor formulation when a current in the heater structure is less than a reference level. Accordingly, the occurrence of an unpleasant taste resulting from overheating may be reduced or prevented.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: December 29, 2020
    Assignee: ALTRIA CLIENT SERVICES LLC
    Inventor: David Alvarez
  • Patent number: 10858490
    Abstract: A porous ultra-thin polymer film has a film thickness of 10 nm-1000 nm. A method of producing the porous ultra-thin polymer film includes dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: December 8, 2020
    Assignees: Nanotheta Co, Ltd., Shinji Takeoka, Toray Industries, Inc.
    Inventors: Shinji Takeoka, Akihiro Saito, Hong Zhang, Natsuki Takamizawa
  • Patent number: 10850289
    Abstract: The present invention is directed to improvements related to the generation of aerosols and outlines an apparatus and methods which supports deagglomeration and counteracts reagglomeration of aerosol particles. The apparatus is provided with an arrangement of inlet conduits for pressurized gas that promote transportation with a rotational flow towards an exit conduit. In order to further support production of high quality aerosols, the apparatus can be provided with an impactor aligned with the exit conduit with at least one impacting surface that minimizes formation of impact residues.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: December 1, 2020
    Assignee: INHALATION SCIENCES SWEDEN AB
    Inventor: Per Gerde
  • Patent number: 10842952
    Abstract: The present invention relates to an inhaler which is appropriate for delivery of medicament in dry powder form used in respiratory diseases, particularly in asthma and chronic obstructive pulmonary disease (COPD). In addition, the present invention relates to an inhaler which includes a blister package appropriate for carrying the medicament in dry powder form and used to realize an effective inhalation.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: November 24, 2020
    Assignee: Sima Patent ve Lisanslama Hizmetleri Ltd. Sti.
    Inventor: Mahmut Bilgic
  • Patent number: 10828432
    Abstract: The present invention provides for a particulate delivery device capable of facilitating both respiratory delivery of compositions under negative pressure and positive pressure. The device comprises an actuator, movable by negative pressure or positive pressure, to allow for gas flow through the device and simultaneously assist with delivery of the particulate into a vortex chamber prior to delivery to the airway of a subject.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: November 10, 2020
    Assignee: De Motu Cordis Pty Ltd
    Inventors: Brendan O'Flaherty, Johann Lipman, Patrick Joseph Lynch
  • Patent number: 10828433
    Abstract: The invention refers to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when actuated by the patient.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: November 10, 2020
    Assignee: ASTRAZENECA AB
    Inventors: Martin Herder, Gerhard Ludanek, Ingo Mett, Joachim Schmidt
  • Patent number: 10814077
    Abstract: A substance delivery module and apparatus for delivering substance in aerosol form are disclosed. The substance delivery module includes a plurality of substance containers and a plurality of pistons, with each substance container being mounted in the module for cooperation with a dedicated piston. Another substance delivery module is disclosed that includes a piston defining a delivery axis and a substance container, moveably mounted with respect to the piston. The substance container is moveable along the delivery axis and may, for example, be moved toward and onto the piston. Either of the substance delivery modules may be assembled with an aerosol generator and an aerosol delivery conduit in fluid communication with the aerosol generator to form an apparatus for delivering substance in aerosol form. The apparatus may further include a control module.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: October 27, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Anthony Dyche, Ian Thomas Petherbridge
  • Patent number: 10806876
    Abstract: A positive exhalation pressure device (1) is described. The device (1) comprises a housing (2) having an annular chamber (5), a chamber inlet (6) configured to permit air into the chamber, a chamber outlet (7) configured to permit air out of the chamber, and a mouthpiece (8) in fluid communication with the chamber inlet. A movable body such as a ball (3) is disposed in the housing within the annular chamber and configured to revolve around the annular chamber in response to flow of air through the chamber from the chamber inlet to the chamber outlet. The movable body is configured to at least partially block the chamber outlet as it revolves around the annular chamber causing cyclical fluctuations in airflow resistance.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 20, 2020
    Assignee: Solopep Limited
    Inventors: Kevin J. O'Sullivan, Leonard W. O'Sullivan, Colum Dunne, Barry Linnane, Deirdre McGrath
  • Patent number: 10806872
    Abstract: The present disclosure relates to a dose indicator comprising, a chassis comprising a chassis frame and a displacement portion comprising a drive part to engage an indexable first display unit indexable about a first display axis, the indexable first display unit comprising a drive tooth to drive an indexable second display unit indexable about a second display axis, the second display axis being non-coaxial with the first display axis, the indexable second display unit comprising two or more second display unit indexing teeth, wherein the drive tooth and each of the second display unit indexing teeth comprise lips on their respective engagement surfaces, the drive tooth lip and second display unit indexing tooth lip each being adapted to engage at an engagement angle that produces a resultant force acting to pull the first display unit and second display unit together. The present disclosure further relates to an actuator for an inhaler, wherein the actuator comprises a dose indicator as described above.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: October 20, 2020
    Assignee: KINDEVA DRUG DELIVERY L.P.
    Inventor: Stephen J. Howgill
  • Patent number: 10792444
    Abstract: A dose indicator or dose counter is disclosed which includes an indexable first display unit indexable about a first display axis, an indexable second display unit indexable about a second display axis, the second display axis being transverse to the first display axis, and a chassis comprising a chassis frame, a displacement portion comprising a drive means to engage the first display unit, and at least one hinge means directly or indirectly connecting the displacement portion and chassis frame. The drive means is preferably configured to index the dose indicator. The dose indicator/counter has a small number of components yet is effective, reliable and compact.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: October 6, 2020
    Assignee: Kindeva Drug Delivery L.P.
    Inventors: Adam J Stuart, Stephen J Howgill
  • Patent number: 10786637
    Abstract: A delivery device is provided having a container containing a dose of greater than 40 mg of a powder and having at least one exit orifice for dispensing the dose from the container, a chamber adapted to receive the container in an operative configuration, at least one gas inlet by which gas may enter the chamber and at least one gas outlet by which gas and entrained powder may exit the chamber. The delivery device is operable to generate a gas flow through the chamber between the at least one gas inlet and the at least one gas outlet, which brings about orbital motion of the container within the chamber in that at least a central region of the container orbits a central axis of the chamber.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: September 29, 2020
    Assignee: Pharmaxis Ltd.
    Inventors: Philip Seeney, Douglas Ivan Jennings
  • Patent number: 10786456
    Abstract: A stable dry powder composition for inhalation includes acetylsalicylic acid in particles having a mass median aerodynamic diameter (MMAD) in a range of about 1 ?m to about 5 ?m. The dry powder composition may contain a pharmaceutically acceptable excipient, such as a stearate, in an amount ranging from about 0.04% (w/w) to about 0.06% (w/w), or from about 0.4% (w/w) to about 0.6% (w/w), of the composition.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: September 29, 2020
    Assignee: OTITOPIC INC.
    Inventor: Kambiz Yadidi
  • Patent number: 10772832
    Abstract: A respirable dry powder including acetylsalicylic acid in particles has a mass median aerodynamic diameter (MMAD) within a range of about 0.5 ?m to about 10 ?m. The respirable dry powder may contain a pharmaceutically acceptable excipient, such as a phospholipid, in an amount ranging from about 0.1% (w/w) to about 10% (w/w) of the particles.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: September 15, 2020
    Assignee: OTITOPIC INC.
    Inventor: Kambiz Yadidi
  • Patent number: 10773034
    Abstract: The present invention relates to an inhaler device for delivering a dose of medicament in dry powder form from a container to a patient in need thereof. The inhaler comprises first and second airflow paths (80, 85) which are arranged such that during inhalation, a capsule (40) having a longitudinal axis and first and second end sections (90, 95) delimiting the capsule on opposing ends located in a capsule chamber (30) performs an oscillating movement in the capsule chamber parallel to its longitudinal axis between first and second sidewall portions (60, 65) of the capsule chamber.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 15, 2020
    Assignee: Presspart Manufacturing Ltd.
    Inventors: Julian Hemy, Richard Turner, Hans-Peter Schmelzer, Hans-Jürgen Neugebauer, Dietmar Schmitz, Stefan Hoffmann, Ameet Sule, Sunita Sule, Matthias Seiler, George Alexander Bostock, Aki Hannu Einari Laakso, Michael Worth
  • Patent number: 10765602
    Abstract: The present disclosure relates to a medication delivery system including a medication administration device, a medication within the medication administration device, a container defining a cavity receiving the medication administration device, and a cap attached to the container and sealing the medication administration device within the cavity. The medication administration device includes an actuator extending from a body and operable to expel the medication by depressing the actuator into the body. The cap includes hold down members positioned to bear against the body of the medication administration device to prevent movement of the medication administration device toward the cap beyond a predetermined distance. The medication administration device is thereby prevented, inter alia, from prematurely discharging the medication during storage and transport.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: September 8, 2020
    Assignee: Eli Lilly and Company
    Inventors: Jaime Ray Arnett, Andrew Thomas Snow
  • Patent number: 10751488
    Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: August 25, 2020
    Assignee: MannKind Corporation
    Inventors: Chad C. Smutney, P. Spencer Kinsey, Carl R. Sahi, Benoit Adamo, John M. Polidoro
  • Patent number: 10737042
    Abstract: A thermally modulating inhalable medicament delivery device may deliver an inhalable medicament as an aerosol, vapor, or partial aerosol and partial vapor mixture. The inhalable medicament may be delivered to a target in a subject. Described herein are devices, systems, and methods for delivering an inhalable medicament to a subject.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: August 11, 2020
    Inventor: Michael Edward Breede
  • Patent number: 10736352
    Abstract: A smoking-pipe includes a pipe body, a cylinder, and a cylinder cover. The cylinder includes a plurality of smoking-chambers which may hold a reserve of combustible material for smoking. The cylinder may be positioned selectively to allow one smoking chamber at a time to be combusted, effectively providing a pipe which may be smoked through multiple sessions without requiring continual repacking.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: August 11, 2020
    Inventor: Ryan Eckhoff
  • Patent number: 10729862
    Abstract: A device (20) is disclosed for dispensing a fluid supplied from an external fluid source. The device comprises a transducer (32) adapted to receive a fluid from the fluid source, and a collapsible linkage and trip link (502) coupling the transducer and the fluid source. The linkage has a collapsible joint inhibiting discharge of the fluid source when in a locked orientation. The device (20) further comprises a moveable member coupled to the linkage such that inhalation forces on the device cause the linkage to collapse thereby discharging the fluid from the fluid source. The device may further include a dose counter coupled to the fluid source for registering the amount of doses administered from the fluid source.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: August 4, 2020
    Assignee: CIPLA (EU) LIMITED
    Inventors: Frank Pieters, Xerxes Rao
  • Patent number: 10722666
    Abstract: A nebulizer includes a replaceable container with fluid to be nebulized. The container includes an inseparable indicator device. The container and the indicator device are axially moved during nebulization and tensioning of the nebulizer. The indicator device controls locking of the nebulizer against further use if a predetermined number of uses has been reached or exceeded.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: July 28, 2020
    Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Joachim Eicher, Markus Mueller, Robert Gerhard Winkler
  • Patent number: 10716904
    Abstract: The present invention provides in part dry powder inhaler (DPI) devices for dispensing dry powder and methods for using the same. The DPI devices feature exchangeable cartridges having drum mechanisms that prepare metered doses of dry powder, and are able to direct air in a turbulent manner sufficient to entrain and deagglomerate a dose of dry powder for delivery into a user's lungs. The DPI devices feature a reservoir of dry powder advanced by a plunger, as well as a gauge that advances with the plunger to indicate the amount of dry powder remaining in the reservoir.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: July 21, 2020
    Assignee: Philip Morris Products S.A.
    Inventors: James Tibbatts, Robin Craig Cocker, Ben Alexander King, Christopher Iain Davidson, Paul Mutti, Alex Stenzler, Steve Han
  • Patent number: 10682476
    Abstract: A dry powder inhaler includes a powder storage element configured to hold a powdered medicament and an inlet channel receives powdered medicament from the powder storage element that is entrained in an airflow. The inlet channel has a first diameter and defines an opening. The inhaler includes a dispersion chamber that receives the airflow and the powdered medicament from the opening. The dispersion chamber has a second diameter. The inhaler includes an actuator housed within the dispersion chamber. The actuator oscillates within the dispersion chamber when exposed to the airflow to deaggregate the powdered medicament entrained by the airflow passing through the dispersion chamber. A ratio between the first diameter and the second diameter is between about 0.40 and 0.60 such that an audible sound is produced as the actuator oscillates. The inhaler includes an outlet channel through which the airflow and powdered medicament exit the inhaler.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: June 16, 2020
    Assignee: Respira Therapeutics, Inc.
    Inventors: Robert M. Curtis, Dan Deaton, James Hannon, Hugh Smyth, Zhen Xu, Martin J. Donovan
  • Patent number: 10668231
    Abstract: The present invention discloses a device useful for facilitating delivery of drugs or medicaments to the respiratory system of a user. The device comprising a mechanism for interrupting the airflow during inhalation or exhalation performed by the user through the device by generating pressure pulses within the respiratory system of the user, such that the delivery of the drugs to the user is facilitated; the pressure pulses are selected from the group consisting of: inspiratory Negative Pressure (NP) pulses, inspiratory Positive Pressure (PP) pulses, expiratory Negative Pressure (NP) pulses, expiratory Positive Pressure (PP) pulses into the respiratory system, and any combination thereof.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: June 2, 2020
    Assignee: RESPINOVA LTD.
    Inventor: Yuval Avni
  • Patent number: 10668230
    Abstract: A nebulizer and a method of breathing using the nebulizer is described. The nebulizer and breathing techniques are capable of delivering medicament into the sinus cavity of a user.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: June 2, 2020
    Assignee: Kurve Technology, Inc.
    Inventor: Marc Giroux