Particulate Treating Agent Carried By Breathed Gas Patents (Class 128/203.15)
  • Patent number: 11998688
    Abstract: Nasal medication or drug delivery devices and methods for delivering adjustable or variable metered volumetric doses of medication or drugs to a nasal passageway of a user or patient. Relative movement between portions of a reservoir establish a set volume of medication for delivery. The delivery device may include a nosepiece for fitting into the nostril of the user or patient, a medication or drug reservoir or dosing chamber, and an external reservoir adapter for providing the medication from an external reservoir.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: June 4, 2024
    Assignee: Indev, LLC
    Inventors: Kevin Simpson, Nicholas Norman, Alan Snyder
  • Patent number: 11969544
    Abstract: The present disclosure describes an inhaler for the inhalation of powder medication. The inhaler has a body and at least one reservoir containing powder medication, the body having an air inlet and an outlet for the transmission to a patient of air entering the body through the air inlet and powder medication. The outlet has a total cross-sectional area for flow which is more than 80% of the total cross-sectional area of the air inlet.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: April 30, 2024
    Inventor: Daniel Buck
  • Patent number: 11969547
    Abstract: There is described a multi-unit dose dry powder medicament delivery device comprising: a first element comprising a single use nozzle located in a body which is at least partially lined with an inner member, said inner sleeve comprising an airway and a cartridge seat; and a second element adapted to be releasably attached to the first element, said second element comprising an actuator provided with an air source and a valve.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: April 30, 2024
    Assignee: Indosys Limited
    Inventors: Robert Nichol Boyes, Philip Wilson Braithwaite
  • Patent number: 11969546
    Abstract: A mouthpiece for an apparatus for generating an inhalable medium is disclosed. The mouthpiece defines an aperture extending from a first opening at a first end of the mouthpiece to a second opening at an opposing end of the mouthpiece. The mouthpiece is arranged to receive in the aperture through the first opening a flavor element for imparting a flavor to a flow of at least one of a vapor and an aerosol that passes through the mouthpiece in use. The aperture has a first radial dimension towards the first opening, and a second radial dimension towards the second opening, wherein the second radial dimension is smaller than the first radial dimension.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: April 30, 2024
    Inventors: Dominic Woodcock, Ugurhan Yilmaz
  • Patent number: 11938274
    Abstract: The present disclosure relates to a ventilation valve configured to be mounted to a liquid reservoir of an electronic atomizing device. The ventilation valve includes: a valve sleeve connected to the liquid reservoir and provided with a through hole, the through hole in communication with a storage cavity of the liquid reservoir; and a valve element having air permeability and including an oleophobic material layer adjacent to the storage cavity, and a semi-permeable membrane connected to an end of the oleophobic material layer away from the storage cavity, the oleophobic material layer filling at least a part of the through hole.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: March 26, 2024
    Inventors: Changyong Yi, Zhenlong Jiang, Congwen Xiao, Xiaoping Li, Lingrong Xiao
  • Patent number: 11931506
    Abstract: A novel dry powder inhaler. By providing a plurality of capsule chambers (1a, 1b, 1c, 1d) arranged in parallel in a capsule dry powder inhalation device, a medicine dispenser containing active components of a composite product or their mixture separately is provided. The dry powder inhaler has a simple structure and is convenient to operate. In addition, the parameters of air inlet channels and an air outlet channel can be adjusted by means of each capsule chamber (1a, 1b, 1c, 1d) according to the properties of powder of a medicine or a combination, so as to provide an appropriate particle distribution for each active component.
    Type: Grant
    Filed: November 22, 2018
    Date of Patent: March 19, 2024
    Inventors: Changhui Li, Ping Dong, Xuebing Zhu
  • Patent number: 11925749
    Abstract: A pharmaceutical drug delivery device and method of preventing drying out and drooling of an ejection head for the drug delivery device. The device includes a drug delivery device body; a fluid outlet nozzle attached to the drug delivery device body; and a fluid jet ejection cartridge containing a liquid pharmaceutical drug disposed in the drug delivery device body. A fluid ejection head is attached to the fluid jet ejection cartridge and the fluid ejection head is in fluid flow communication with the fluid outlet nozzle. An elongate, serpentine air flow path is provided between and outer surface of the fluid jet ejection cartridge and an inner surface of the fluid outlet nozzle. The elongate, serpentine air flow path provides a reduced pressure differential adjacent to a surface of the fluid ejection head upon use of the drug delivery device and provides a humidification zone.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: March 12, 2024
    Assignee: Funai Electric Co., Ltd.
    Inventors: James D. Anderson, Jr., Michael A. Marra, III
  • Patent number: 11878111
    Abstract: A venturi inhalation device is provided. The device has a tube defining an internal volume with a fine bore needle disposed at one end. The fine bore needle is in fluid communication with the internal volume of the tube such that medication stored therein can pass into the needle. The tube has a second end which can be sealed to contain the medication until the device is used. A hollow housing is sized and shaped to receive the tube in close tolerance, whereupon the tube being so received, an air-tight seal is formed. The housing also includes a venturi restriction, and when the tube is received by the first end of the housing, a distal end of the fine bore needle is placed within the venturi restriction. A mouthpiece is disposed on a second end of the housing enabling a user to inhale the medication in the tube.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: January 23, 2024
    Inventor: Max Azevedo
  • Patent number: 11878114
    Abstract: This disclosure relates to nicotine powder inhalers where the nicotine powder is delivered at air flow rates that mimic a smoking regime.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: January 23, 2024
    Assignee: Philip Morris Products S.A.
    Inventors: Ihar Nikolaevich Zinovik, Gerard Zuber
  • Patent number: 11872343
    Abstract: A ventilator system includes a first air tank, a plurality of second air tanks communicated with the first air tank, a plurality of breathing devices respectively communicated with the second air tanks, a plurality of first vacuum tanks respectively communicated with the breathing devices, and a second vacuum tank communicated with the first vacuum tanks. The first air tank has a positive pressure relative to the second air tanks. The second vacuum tank has a negative pressure relative to the first vacuum tanks.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: January 16, 2024
    Inventors: Chen-Kun Liaw, Tai-Yin Wu, Yu-Ciao Liao, Yu-Yan Liao, Hsiang-Hung Liaw, Yu-Peng Liao, Yi-Hsuan Liao, Yen-Chun Liao, Chih-Ling Liao
  • Patent number: 11833539
    Abstract: A device for fluidizing and delivering a powdered agent, including a canister extending longitudinally from a first to a second end and defining a space within which a powdered agent is received, an inlet coupleable to a gas source for supplying gas to the space to fluidize the powdered agent to create a fluidized mixture, an outlet via which the gas mixture is delivered to a target area, a tube extending from the outlet into the interior space, the tube including a slot extending through a wall thereof so that gas mixture is passable from the interior space through the outlet via the second end and the slot, and a door movably coupled to the tube so that the door is movable over the slot to control a size of the slot open to the interior space of the canister.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: December 5, 2023
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Andrew Pic, Joseph King, Amanda Smith, Jessica Grimsby, John Favreau, Lauren Lydecker
  • Patent number: 11825878
    Abstract: Apparatus and methods are described for use with a vaporizer that vaporizes at least one active ingredient of a plant material. In response to receiving a first input to the vaporizer, the plant material is heated, in a first heating step. An indication of the temperature of the plant material is detected, and, in response to detecting an indication that the temperature of the plant material is at a first temperature, the first heating step is terminated, by withholding causing further temperature increase of the plant material. The first temperature is less than 95 percent of the vaporization temperature of the active ingredient. Subsequently, a second input is received at the vaporizer. In response thereto, the plant material is heated to the vaporization temperature, in a second heating step. Other applications are also described.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: November 28, 2023
    Assignee: Altria Client Services LLC
    Inventor: Yossef Raichman
  • Patent number: 11793951
    Abstract: The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: October 24, 2023
    Inventors: Brendan O'Flaherty, Johann Lipman, Patrick Joseph Lynch, John Fredatovich
  • Patent number: 11779715
    Abstract: Disclosed is a dry powder inhaler for delivering medicament from at least one blister pack, each blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhaler comprises: a housing for accommodating unused and used portions of the at least one blister pack together with a dispensing mechanism for simultaneously opening at least two blister pockets at a time; and a manifold component through which air can be drawn in use of the inhaler.
    Type: Grant
    Filed: October 18, 2022
    Date of Patent: October 10, 2023
    Inventors: Peter John Crowley, Jan Geert Hazenberg, Daniel Buck, Josh Gottesman
  • Patent number: 11752282
    Abstract: Taught herein is a disposable breath actuated dry powder drug inhalation device having a powderized drug storage chamber with integral toroidal geometry and air flow pathways for entraining and breaking up powder aggregates prior to delivery to the patient. The toroidal chamber is fluidly connected by one or more air inlets directed in a non-tangent manner toward the powder to loft and set up an irregular-rotational flow pattern. Also, in fluid connection with the toroidal chamber is a centrally or near centrally located air and powder outlet consisting of one or more holes forming a grid in fluid connection with a channel providing a passageway for powder flow to the patient.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: September 12, 2023
    Assignee: Concentrx Pharmaceuticals, Inc.
    Inventor: Eric Carl Richardson
  • Patent number: 11744836
    Abstract: A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: September 5, 2023
    Assignee: Liquidia Technologies, Inc.
    Inventors: Robert Frank Roscigno, Brian T. Farrer, Jacob J. Sprague, Benjamin Maynor
  • Patent number: 11730898
    Abstract: An inhaler for inhalation of an inhalable dry powder is provided. The inhaler has (a) an outer shell having a first shell part and a second shell part; (b) a capsule holder having a chamber for holding a capsule, a capsule breaker for breaking open a capsule held within the chamber and a trigger for causing the capsule breaker to break open a capsule; (c) a support for supporting the capsule holder; and (d) an outlet for passage of dry powder from the capsule into a user. The capsule holder is positioned in the first shell part which has an aperture through which the trigger protrudes. The aperture has a cut-out in the rim of the first shell part and through which the trigger may pass when the capsule holder is removed from the first shell part.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: August 22, 2023
    Assignee: MERXIN LTD
    Inventors: Graham Purkins, Carol Balfour, Gavin Kovacs, Philippe Rogueda
  • Patent number: 11717621
    Abstract: The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.
    Type: Grant
    Filed: August 11, 2022
    Date of Patent: August 8, 2023
    Assignee: De Motu Cordis Pty Ltd
    Inventors: Brendan O'Flaherty, Johann Lipman, Patrick Joseph Lynch, John Fredatovich
  • Patent number: 11690964
    Abstract: Containment units, dry powder inhalers, delivery systems, and methods for the same are disclosed. Exemplary devices are configured to have inlets and outlets which are formed with the containment walls of a containment unit. Air jets formed by the configuration of inlet(s) and outlet(s) inside the containment unit create significant turbulence and deaggregate the powder. Delivery system components downstream of the containment unit may integrate the exiting aerosol plume with a low flow nasal cannula air stream for delivery to a subject.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: July 4, 2023
    Assignee: Virginia Commonwealth University
    Inventors: Philip Worth Longest, Michael Hindle, Dale Farkas, Susan Boc
  • Patent number: 11684728
    Abstract: The present invention provides a particulate delivery device with an automatic activation mechanism that pierces or cuts a composition capsule when a cap is removed. The cap cannot be replaced once the device is activated for use. The device allows for gas flow through the device from a gas inlet to a gas outlet through a composition receptacle and dispersion chamber to deliver particulate to the airway of a subject.
    Type: Grant
    Filed: August 11, 2022
    Date of Patent: June 27, 2023
    Assignee: De Motu Cordis Pty Ltd
    Inventors: Brendan O'Flaherty, Johann Lipman, Patrick Joseph Lynch, John Fredatovich
  • Patent number: 11672925
    Abstract: The present invention provides a new inhaler device for the storage and/or administration of inhalable liquids to a patient offering one or more advantages or improvements over known inhalers, particularly inhalers for the delivery of halogenated volatile liquids such as methoxyflurane for use as an analgesic.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: June 13, 2023
    Inventors: Greg Rowland, Edward Linacre, Glenn Gilbert, Viktor Legin
  • Patent number: 11672926
    Abstract: A fluid dispenser device having a dispenser head; an air expeller; and a reservoir containing a single dose of fluid. The reservoir includes a proximal axial end and a distal axial end, and is removably mounted so that after the device has been actuated, the empty reservoir can be removed from the device and replaced by a new full reservoir. The air expeller is adapted to return to its rest position to enable a new actuation with the new full reservoir. The dispenser head includes a proximal perforator tip to perforate the proximal axial end of the reservoir. The device includes a movable perforator member that slides axially around the dispenser head between a loading position and an actuation position and includes a distal perforator tip adapted to perforate the distal axial end of the reservoir when the movable perforator member is moved into its actuation position.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: June 13, 2023
    Assignee: APTAR FRANCE SAS
    Inventor: Franck Poullain
  • Patent number: 11672927
    Abstract: The present invention provides for the integration of drug dispersion methods into a drug or medicine delivery system. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the device. The drug sealing system provides a way of blocking the migration of drug from one area of the package to another.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: June 13, 2023
    Assignee: Manta Devices, LLC
    Inventors: Andrew Jones, Richard L. Miller
  • Patent number: 11623052
    Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: April 11, 2023
    Assignee: MannKind Corporation
    Inventors: Chad C. Smutney, Benoit Adamo, Brendan F. Laurenzi, P. Spencer Kinsey
  • Patent number: 11617842
    Abstract: A dose ring for a dry powder inhaler (DPI) device includes an aluminum foil member covering particulate medication cavities and through holes. The device includes hinged flaps formed by a cut so that one radial side is uncut and forms a hinge. Each flap can cover both a cavity for particulate medication and a through hole located between that cavity and the circular inside edge of the dose ring.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: April 4, 2023
    Assignee: CSP Technologies, Inc.
    Inventors: Jean-Pierre Giraud, Bruce Rabinne, Yutaka Kataoka
  • Patent number: 11590297
    Abstract: A dry powder inhaler with a blister folding device can include a housing to receive a single blister containing a dose of medicament for inhalation by a user, and a mouthpiece through which a dose of medicament is inhaled by a user and a blister opening device. The blister opening device can include a blister support element for supporting a blister containing a dose of medicament for inhalation by a user, and a blister folding element co-operable with the blister support element. The blister folding element and the blister support element can be movable relative to each other between a first position, for insertion of the blister into or onto the blister support element, and a second, burst, position in which the blister folding element has co-operated with the blister support element.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: February 28, 2023
    Inventors: Roger Clarke, Peter Wilson
  • Patent number: 11590301
    Abstract: The present invention relates to an aerosol-generating device (1) for generating an aerosol by dispersing an aerosol-forming powder (31) into an airflow. The device comprises a device housing (2) which comprises an airflow passage therethrough and which is configured to receive a capsule (30) that contains the aerosol-forming powder to be discharged into the airflow passage. The device further comprises a magnetic actuator (40) which is configured to generate a movement of the capsule when being received in the device housing for de-agglomerating the aerosol-forming powder within the capsule. The invention further relates to an aerosol-generating system comprising an aerosol-generating device according to the invention and an aerosol-forming powder containing capsule for use with the aerosol-generating device.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: February 28, 2023
    Assignee: Philip Morris Products S.A.
    Inventor: David Cross
  • Patent number: 11571524
    Abstract: A system for respiration-controlled application of aerosol in powder form during artificial respiration or assisted respiration of a patient including an interface contacting the patient's respiratory tract, a unit for generating a respiratory gas flow, at least one inspiration line through gas flow is conducted to the interface, an aerosol generator, at least one aerosol line through which the generated aerosol is conducted from the aerosol generator to the interface, and a respiration sensor that detects the patient's respiration signal. A valve in the at least one aerosol line is controlled based on the detected respiratory signal. An intermediate store for generated aerosol in powder form is arranged between the valve and the aerosol generator. The gas flow has a first pressure that is higher than or equal to ambient pressure and the aerosol has a second pressure that is higher than or equal to the first pressure.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: February 7, 2023
    Inventors: Gerhard Pohlmann, Felix Carl Wiegandt, Peter Iwatschenko
  • Patent number: 11571531
    Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: February 7, 2023
    Assignee: OptiNose Inc.
    Inventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
  • Patent number: 11491288
    Abstract: A dispenser for dispensing one or more dry-powder inhaler devices, having at least one compartment configured to hold at least one dry-powder inhaler device, the at least one dry-powder inhaler device comprising a casing enclosing at least one compartment containing an inhalable medicament covered by a cover, and at least one puncture mechanism comprising at least one pin structure operably aligned with the at least one compartment, and at least one obstruction internally located within the dispenser and adjacent to an opening, wherein, upon a dry-powder inhaler device being pulled from a dispenser, the at least one obstruction is configured to actuate the at least one puncture mechanism to extend the at least one pin structure into the casing, thereby puncturing the cover of the at least one compartment.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: November 8, 2022
    Inventors: David R. Elmaleh, Maxim D. Elmaleh
  • Patent number: 11491143
    Abstract: The present invention relates to methods and compositions for the treatment and prophylaxis of pulmonary arterial hypertension (PAH) in a human subject in need of such treatment, the methods comprising the pulmonary administration to the subject, preferably via inhalation of a composition comprising rapamycin or a prodrug or derivative thereof.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: November 8, 2022
    Assignee: AI Therapeutics, Inc.
    Inventors: Thomas Armer, Lawrence S. Melvin, Jr., Jonathan M. Rothberg, Henri Lichenstein
  • Patent number: 11484671
    Abstract: An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism within the housing. The puncturing mechanism comprises an alignment guide and a puncture member, wherein the alignment guide comprises a surface adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: November 1, 2022
    Inventors: Michael John Dunkley, Jon David Tuckwell, Edward William Vernon-Harcourt, Mark Glusker, Steve Paboojian
  • Patent number: 11471623
    Abstract: A dry powder inhaler includes a powder storage element configured to hold a powdered medicament and an inlet channel receives powdered medicament from the powder storage element that is entrained in an airflow. The inlet channel has a first diameter and defines an opening. The inhaler includes a dispersion chamber that receives the airflow and the powdered medicament from the opening. The dispersion chamber has a second diameter. The inhaler includes an actuator housed within the dispersion chamber. The actuator oscillates within the dispersion chamber when exposed to the airflow to deaggregate the powdered medicament entrained by the airflow passing through the dispersion chamber. A ratio between the first diameter and the second diameter is between about 0.40 and 0.60 such that an audible sound is produced as the actuator oscillates. The inhaler includes an outlet channel through which the airflow and powdered medicament exit the inhaler.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: October 18, 2022
    Assignee: Respira Therapeutics, Inc.
    Inventors: Robert M. Curtis, Dan Deaton, James Hannon, Hugh Smyth, Zhen Xu, Martin Donovan, Aileen Gibbons
  • Patent number: 11458093
    Abstract: A method includes combining nicotine with a liquid carrier to form a liquid mixture and spray drying the liquid mixture to form a first plurality of particles. The first pluralities of particles are then milled to form a second plurality of particles.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: October 4, 2022
    Assignee: Philip Morris Products S.A.
    Inventor: Nicolo Volpe
  • Patent number: 11458098
    Abstract: The present disclosure provides a dry powder composition of treprostinil prodrugs and a method of treating pulmonary hypertension (e.g., pulmonary arterial hypertension), portopulmonary hypertension, or pulmonary fibrosis in a patient in need thereof. The dry powder composition includes (a) from about 0.1 wt % to about 3 wt % of a compound of Formula (I): or an enantiomer, diastereomer, or a pharmaceutically acceptable salt thereof, (b) from about 0.01 wt % to about 3 wt % of DSPE-PEG2000, (c) from about 10 wt % to about 50 wt % of leucine, and the balance being (d) a sugar selected from the group consisting of trehalose and mannitol. The entirety of (a), (b), (c), and (d) is 100 wt %, and R1 is tetradecyl, pentadecyl, hexadecyl, heptadecyl, or octadecyl. The method includes administering an effective amount of the dry powder composition to the lungs of the patient by inhalation via a dry powder inhaler. In certain compositions and methods provided herein, R1 is hexadecyl, e.g., linear hexadecyl.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: October 4, 2022
    Assignee: Insmed Incorporated
    Inventors: Ju Du, Adam Plaunt, Vladimir Malinin
  • Patent number: 11452825
    Abstract: An inhaler article includes a tubular housing defining a holder body extending along a longitudinal axis from a mouthpiece end to a consumable receiving end. The holder body includes an inner tube extending along the longitudinal axis and within the tubular housing from a tube intake end to a tube exhaust end. The tube intake end is proximate the consumable receiving end. The inner tube defines an air flow lumen with two or more air flow apertures extending through a wall of the inner tube. An air blocking feature is positioned in the air flow lumen and between two of the air flow apertures. A vibration inducing element disposed on the inner tube proximate to the tube exhaust end or the tube intake end, the vibration inducing element comprises an aperture through the wall of the inner tube and having a tapered or angled downstream aperture edge.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: September 27, 2022
    Assignee: Philip Morris Products S.A.
    Inventor: Frederic Ulysse Buehler
  • Patent number: 11439776
    Abstract: An inhalation delivery device for dry powder with adjusting resistance through detachable heads, which combines four different detachable heads and uses a single base. The desired resistance and the medicament delivery/allocation to the lungs, are set, offering a practical, low cost solution while, at the same time, a high performance personalized treatment. The detachable head (1) comprises a mouthpiece (2) for the mouth of the patient, a medicament intake orifice (3) sized to fit into the mouth of a patient and a protrusion (4) for a sliding connection between the detachable head (1) and the base (5), via notches (6) carried by the base (5). Each detachable head (1) possesses a corresponding protrusion (4) which may be fitted onto the base (5). The device comprises typically four different heads (1), covering the entire spectrum of patients accordingly to their inhalation capacity, the medicament type/dose and the targeted point of treatment.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: September 13, 2022
    Inventors: Konstantinos Zarogoulidis, Nikolaos Michailidis
  • Patent number: 11426538
    Abstract: An actuator for a pressurized metered dose inhaler providing a significant reduction in the non-respirable coarse fraction of the emitted aerosol medicament impacting in the oro-pharynx, with consequent less associated side effects and oral candidiasis in the patient, due to the fact that the mouthpiece portion has a central rounded opening of a well-defined width and distance from the nozzle aperture and also provided with a cylindrical recess, whose central axis is aligned with the central longitudinal axis of the mouthpiece portion and with the central longitudinal axis of the nozzle channel.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: August 30, 2022
    Inventors: Diego Copelli, Andrea Casazza
  • Patent number: 11426539
    Abstract: An inhaler housing with a receiving portion adapted to at least partially receive a container containing a medicament, and a dispensing portion through which the medicament is dispensed. The receiving portion and the dispensing portion are movable relative to one another between a storage condition, in which the receiving portion and the dispensing portion at least partially overlie one another and, a use condition. The dispensing portion and the receiving portion are configured to move between the storage condition and the use condition using both a sliding movement and a pivoting movement.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: August 30, 2022
    Inventor: Heath Rainbow
  • Patent number: 11419863
    Abstract: A composition containing apomorphine and a divalent metal cation, such as, for example, Zn2+, Ca2+, or Mg2+, is disclosed. The composition contains apomorphine and the divalent metal cation in a molar ratio of 2 or less. Optionally, the composition contains an antioxidant. The composition can be prepared as a medicament for treating Parkinson's disease.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: August 23, 2022
    Inventor: Ian Philip Leader
  • Patent number: 11318234
    Abstract: Irrigation and/or aspiration devices and methods may be configured to aspirate and irrigate alone, sequentially, or concurrently. The devices and methods may provide a base with a removable head, and adapted for partial or complete separation of the irrigation and aspiration functions. The devices and methods can be configured to aspirate and/or irrigate the nasal and sinus cavities. The devices and methods may be manually and/or automatically controlled. The devices and methods may include removable, and/or replaceable, and/or refillable, and easily cleanable reservoirs for aspirant and irrigant. The device head and/or aspirant reservoir may comprise a diagnostic device, i.e., test device and/or container after use of the devices and methods.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: May 3, 2022
    Assignee: Aardvark Medical, Inc.
    Inventors: Peter C. Baker, Clinton N. Slone, Michael J. Strasser, James M. Lovette, Thomas King, Richard Treadwell
  • Patent number: 11298476
    Abstract: Disclosed is an inhaler and a method for using the inhaler for the inhalation of a formulation from a carrier. The carrier contains the formulation in a receptacle and is set oscillating by an air current. An improved or defined delivery and nebulisation of the preferably powdered formulation is made possible by the fact that the carrier is set oscillating in defined manner, the formulation is dispensed through a cover element having three to five holes and/or the air current flows onto a fin associated with the carrier and flows past at least substantially only one flat side of the carrier.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: April 12, 2022
    Inventors: Andree Jung, Stephen Terence Dunne
  • Patent number: 11291781
    Abstract: An inhaler device for pulmonary delivery of at least one substance from a drug dose cartridge to an inhaling user, including: a first conduit for conducting a carrier airflow to a proximal opening of a mouthpiece for use by the user; a holder configured to position the dose cartridge within the carrier airflow; and a second conduit for conducting a shunting airflow to the mouthpiece without passing through the dose cartridge position. In some embodiments, a controller connected to a valve controls a rate of carrier airflow, for example by controlling the shunting airflow, based on a sensor indication of airflow rate and a target airflow profile.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: April 5, 2022
    Assignee: Syqe Medical Ltd.
    Inventors: Perry Davidson, Aaron Schorr, Binyamin Schwartz
  • Patent number: 11260190
    Abstract: A molded breathing appliance for supporting a nasal oxygen tube having an upper bite rim, a lower bite rim, a moldable material disposed within the upper bite rim and lower bite rim for conforming to a patient's maxillary bite impression and mandibular bite impression, respectively, an L-shaped member extending outwardly perpendicular to the upper bite rim, and a transverse support disposed on the L-shaped member and configured with a plurality of sets of oxygen tube finger clamps to retain a nasal oxygen tube in proximity with a patient's nostrils.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: March 1, 2022
    Inventor: Leonard Feld
  • Patent number: 11260184
    Abstract: An inhaler article includes a body extending along a longitudinal axis from a mouthpiece end to a distal end and a capsule cavity defined within the body. The capsule cavity has a length extending along the longitudinal axis. A mouthpiece air channel extends from the capsule cavity to the mouthpiece end. An end cap is disposed within the distal end and extends to the capsule cavity. The end cap includes an air channel extending from the end cap distal end to the end cap inner end. A capsule is disposed within the capsule cavity and has a capsule length. The capsule length is in a range from about 25% to about 99% of the cavity length, or about 50% to about 95% of the cavity length, or about 70% to about 90% of the cavity length, or from about 75% to about 85% of the cavity length, or about 80% of the cavity length.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: March 1, 2022
    Assignee: Philip Morris Products S.A.
    Inventors: Gerard Zuber, Waller Judith, Gennaro Campitelli
  • Patent number: 11253000
    Abstract: A receptacle section for an aerosol provision article, arranged for receiving an element for modifying a property of aerosol passing through said element received in the receptacle section in use. The receptacle section having a configuration defining a flow path for said aerosol to flow through the receptacle section. The receptacle section including a first portion and a second portion moveable, the second portion being slidably mounted to the first portion. The receptacle section being arranged to allow at least one of insertion or removal of the element into or from the receptacle section in a direction substantially perpendicular to the longitudinal axis of the receptacle section.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: February 22, 2022
    Inventors: Richard Hepworth, Colin Dickens
  • Patent number: 11241039
    Abstract: The split airflow system for an electrically heated smoking system for generating aerosol, the split airflow system having a downstream end comprises a first channel defining a first flow route and a second channel defining a second flow route. The first flow route directs ambient air from outside the system to the downstream end of the system. The second flow route directs ambient air from outside the system towards a preferably substantially flat, fluid permeable, heating element before conveying the ambient air to the downstream end. The first channel and the second channel define a total volume of ambient air passing through the system and the first channel provides at least 50 percent of the total volume of ambient air passing through the system. The invention also refers to a method for guiding an airflow in an electrically heated smoking system for generating aerosol and an electrically heated smoking system comprising the split airflow system.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: February 8, 2022
    Assignee: Philip Morris Products S.A.
    Inventors: Eric Force, Oleg Mironov, Ihar Nikolaevich Zinovik, Keethan Dasnavis Fernando
  • Patent number: 11229757
    Abstract: A dry powder inhaler dispenses a partial dosage of a powder from a dry powder chamber during a single user inhalation. In certain embodiments, the dry powder chamber is a dry powder capsule that spins in a chamber with a protrusion for limiting the spin of the capsule. In certain embodiments, a capsule slides in a proximal and distal direction for dispensing partial dosages of powder medicament. Air inlets in communication whit the external environment can be included in the inhaler housing for generating a smooth inhalation experience for the user and facilitating operation of partial dosage mechanisms. In other embodiments, a hinged member, sliding member, rotating member, spring tensioned member, pressure actuated valve, dry powder chamber with patterned holes or combinations of these are used as a mechanism for dispensing a partial dosage of powder medicament during a single inhalation.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: January 25, 2022
    Assignee: Philip Morris Products S.A.
    Inventors: Alex Stenzler, Steve Han, Arthur Slutsky, Steven Ellis, Noe Zamel, William Alston
  • Patent number: 11224705
    Abstract: An inhaler for inhalation of a formulation in powder form includes: a magazine which is rotatable and contains pre-dosed doses of the formulation in capsules, a housing which is substantially round or disc-shaped, the housing having a housing part in which the rotatable magazine is disposed, where the housing part is fixedly coupled to the rotatable magazine, and is removable from the housing in order to facilitate replacement of the magazine by inserting a new magazine.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: January 18, 2022
    Inventors: Holger Holakovsky, Jens Besseler, Jessica Frentzel-Beyme, Frank Herrmann
  • Patent number: 11224704
    Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: January 18, 2022
    Assignee: MANTA DEVICES, LLC
    Inventors: Andrew Jones, Richard L. Miller