Abstract: A dry powder inhaler including a main body, a plurality of individual reservoirs, such as blisters, each containing a single dose of powder, and disposed one behind another on a flexible strip, and an opening mechanism provided for opening an individual reservoir each time the device is actuated. The device includes first a displacement mechanism adapted to displace an individual reservoir to face the opening mechanism before and/or after each actuation, and a second displacement mechanism adapted to displace an individual reservoir against the opening mechanism on each actuation. The first displacement mechanism having an indexer wheel provided with a recess that receives an individual reservoir, the recess defined by a bottom wall and an inner side wall of said indexer wheel, and by an outer side wall formed on a separate adjustment element assembled on the indexer wheel.

Abstract: An inhaler is disclosed. It comprises a housing to receive a strip having a plurality of blisters, each blister having a breachable lid and containing a dose of medicament for inhalation by a user, an indexing wheel mounted in the housing rotatable to drive a strip to sequentially move blisters into alignment with a blister piercing member, a control element pivotally mounted to the housing and a drive mechanism configured to couple the control element to the indexing wheel during part of the rotation of the control element by a user so that the indexing wheel rotates together with the control element.

Abstract: A stable crystalline micronized particulate of a glycopyrronium salt may be prepared by suspending the drug in a water-immiscible anti-solvent in which the drug has little or no solubility and micronizing the suspension. The resulting drug particles are physically stable with regard to agglomeration and/or aggregation on storage.

Abstract: A method of improving cognition in a patient with Down syndrome, which entails intranasally administering one or more ?2-ADR agonists or pharmaceutically-acceptable salts of either or both to the patient in an amount and with a frequency effective to improve cognition of the patient as measured contextual learning tests.

Abstract: A fluid dispenser, including a cover element; a blister strip; a blister opening mechanism; a first displacement mechanism having an indexer wheel; a second displacement mechanism pivoting between a non-dispensing position and a dispensing position; a cocking member for urging the second displacement mechanism towards the dispensing position, the cocking member spring-loaded by opening the cover; a blocking mechanism for retaining the second displacement mechanism in the non-dispensing position; a trigger mechanism for releasing the blocking mechanism; a slidable carriage displaceable between a non-indexing position and an indexing position and including an actuator co-operating with the indexer wheel; a connection mechanism activated during inhalation that connects the carriage with the cover, so as to displace said carriage towards its indexing position when the cover element is brought towards its closed position, and so as to displace said carriage towards its non-indexing position when brought towards it

Abstract: A device for self-administration of fractional amounts of a total volume dose of liquid medicament supplied from a capsule over a period of time for delivery to the sublingual area of a patient. The device contains an inner chamber and a track within which confines a moveable ball. The space between the chamber wall and track permits liquid medication from the capsule to flow past the ball and be available for discharge through an exit port when the ball is not seated upon the exit port.

Abstract: Aerosolizing delivery apparatuses can include cartridges configured to be detachably connected to a delivery device. The cartridges can include: a housing defining a reservoir and a cartridge outlet, the cartridge outlet configured to permit fluid communication between the reservoir and an exterior of the cartridge. A surface of the housing can be configured to define a bypass port between the housing and a surface of the delivery device when the cartridge is assembled with the delivery device.

Abstract: Provided herein is a system that includes a metered dose inhaler device for pulmonary delivering to a subject at least one pre-determined vaporized amount of at least one pharmacologically active agent being in a plant material, wherein vaporization is effected by controllably heating the plant material so as to vaporize a pre-determined vaporized amount of the agent; the system further includes a controller in communication with the inhaler device, configured to control the pre-determined vaporized amount based on data indicative of at least one pharmacodynamic effect induced by the agent in the subject.

Abstract: A nebulizer is proposed which comprises a replaceable container containing fluid, a housing part detachable from the nebulizer for replacing the container, and an operation counter inseparable from the housing part as depicted in exemplary FIG. 10. The operation counter comprises a lead screw and an associated rider both supported by the housing part.

Abstract: An oscillating positive respiratory pressure apparatus and a method of performing oscillating positive respiratory pressure therapy. The apparatus includes a housing having an interior chamber, a chamber inlet, a chamber outlet, an exhalation flow path defined between the inlet and the outlet, and a restrictor member rotatably mounted within the interior chamber. The restrictor member has an axis of rotation that is substantially perpendicular to the flow path at the inlet, and includes at least one blocking segment. Rotation of the restrictor member moves the at least one blocking segment between an open position and a closed position. Respiratory pressure at the chamber inlet oscillates between a minimum when the at least one blocking segment is in the open position and a maximum when the at least one blocking segment is in the closed position. By exhaling into the apparatus, oscillating positive expiratory pressure therapy is administered.

Abstract: The present invention relates to the new indications of chronic obstructive pulmonary disease (COPD) and idiophathic lung fibrosis (IPF) for uridine and uridine analogs.

Abstract: A delivery device is provided which comprises a container containing a dose of a powder and having at least one exit orifice for dispensing the dose from the container and a chamber adapted to receive the container in an operative configuration. The device further comprises at least one gas inlet by which gas may enter the chamber and at least one gas outlet by which gas and entrained powder may exit the chamber. The delivery device is operable to generate a gas flow through the chamber between the at least one gas inlet and the at least one gas outlet, which brings about orbital motion of the container within the chamber in that at least a central region of the container orbits a central axis of the chamber. The volume occupied by the container is at least 25% of the volume of the chamber.

Abstract: An additive manufacturing system is provided. The system includes: a stage, a powder supplying device, an energy beam generating device and an atmosphere controlling module. The powder supplying device provides powder to the stage. The energy beam-generating device generates an energy beam and directs the energy beam to the stage. The atmosphere controlling module includes at least one pair of gas inlet-outlet devices coupled around the stage, and a dynamic gas flow controlling device connected with the gas inlet-outlet devices. The dynamic gas flow controlling device dynamically controls an angle between a flow direction of the gas and a moving direction of the energy beam. The angle is predetermined by a scanning strategy.

Abstract: A method of obtaining a sample of materials includes building a product through an additive manufacturing process. A capsule is formed with an internal chamber inside of the capsule. The capsule is formed during the building of the additive manufacturing product. A sample of powder is encapsulated inside the internal chamber as the capsule is built. The internal chamber is hermetically sealed from an exterior environment to retain the sample of powder in the internal chamber.

Abstract: Provided is a method of mixing first and second liquids having mutual solubility inside a mixing flow channel formed by a micro flow channel. This method includes: causing the first and second liquids to be joined to each other inside the mixing flow channel; and forming a slug flow, in which mixing subject cells (60) formed by the joined liquid and insoluble fluid cells (63) formed by an insoluble fluid are alternately arranged, inside a flow channel at the downstream side of an insoluble fluid supply position in a manner such that the insoluble fluid having insolubility with respect to both mixing subject liquids is supplied to the joined liquid flowing through the flow channel in a direction intersecting the flow channel so that the joined liquid is divided with a gap therebetween, thereby mixing the first mixing subject liquid and the second mixing subject liquid contained in each mixing subject cell inside the downstream flow channel.

Abstract: An inhaler/puffer is provided. The inhaler/puffer may comprise a body, a cap, and a base, the cap and the base being configured to functionally engage the body. The body may define a chamber wherein minerals, such as salt, may be housed. The body, cap, and base may be configured to permit a user to inhale on the cap and draw air through the base into the chamber, over the minerals, through the cap and into the respiratory system of the user. Additionally, the inhaler/puffer may be placed in-line with an oxygen breathing system, such that as the breathing system provides oxygen to the user, the user also receives salt air treatment.

Abstract: The invention relates to a hand-held medicinal device, particularly a nebulizer, for delivering a liquid medicament preparation from a container having a container cap. The medicament preparation may be based for example on an alcoholic solvent or may contain a similar substance with an increased vapor pressure. The proposed nebulizer with the installed container comprises a sealing system made up of two seals at the junction between the device and container, which prevent loss of liquid, diffusion leaks and exchange of gases with the environment at this point.

Abstract: A powder aerosolization apparatus comprises a housing comprising an outlet adapted to be inserted into a user's mouth and one or more bypass air openings. A receptacle support within the housing supports a receptacle containing a powder pharmaceutical formulation. A puncturing mechanism within the housing creates in the receptacle one or more inlet openings and one or more powder outflow openings, wherein the powder outflow openings have a total area of from 0.2 mm2 to 4.0 mm2. Upon a user's inhalation through the outlet, air flows through the one or more bypass air openings and through the receptacle to aerosolize the powder pharmaceutical formulation in the receptacle. In one version, the relative flow parameters between the flow through the one or more bypass openings and the one or more powder outflow openings are selected so that flow of aerosolized pharmaceutical formulation does not occur until a predetermined inhalation flow rate is achieved.

Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

Abstract: An ultrasonic nebulizer including a circuit unit, a nebulization module, and a frequency sweeping unit. Constant electric power in the nebulization module of the ultrasonic nebulizer is maintained by automatic compensation of electric power consumption and/or current consumption. A fixed current consumption and electric power consumption of the nebulization module of the ultrasonic nebulizer is achieved by auto compensation, thereby improving nebulization performance.

Abstract: The invention relates to a grid element for an inhaler which can be arranged in an air duct between a mouthpiece and a capsule chamber of the inhaler, it being possible for turbulence to be generated by means of the grid element in an airflow passing through the air duct. The grid element is characterized in that it comprises a preferably planar grid-type portion having a grid front side which points towards the capsule chamber and a grid rear side, at least one protruding element being arranged on the grid front side, by means of which a capsule that can be arranged in the capsule chamber can be loosely supported.

Abstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.

Abstract: The device (1) for supplying micronized medical salt comprises a container (2) for medical salt, having a vertical longitudinal development and a lower end portion (3) provided with a mouth of release (4) of the medical salt, a screw (20) inserted into the container and having an upper end (21) and a lower end (22) which is free, rotation members (30) of the screw mechanically connected thereto for rotating it with respect to the container, where the screw advances the medical salt downward so that the medical salt is released in a controlled manner from the mouth of release (4), the device further comprising a dispenser (50) which comprises a supply duct (51) and a ventilation member (60) which generates an air flow within the supply duct, where the mouth of release is in communication with the supply duct so as to release the medical salt directly in the air flow.

Abstract: A powder medicament mouthpiece comprising at least one section of through suction tube (1) and a filter (2). One end of the suction tube is a medicament inlet, and the other end (16a) is a suction outlet. The filter (2) is arranged within the suction tube (1). The powder medicament mouthpiece can be connected to multiple models of dry powder inhalers to separate powder medicament from dry powder, and allows for significantly improved efficacy.

Abstract: A unidose blister cutting machine comprises a cartridge for holding blister packs, a first positioning arm for pushing a blister pack in a first direction, a second positioning arm for pushing the blister pack in a second direction substantially orthogonal to the first direction, a flipping robotic arm having a suction means for retaining the blister pack during a flipping movement, a grabbing jaw for grabbing the blister pack from the flipping robotic head, a cutting device, and a collecting chute located below the cutting device for collecting the cut blister packs.

Abstract: The disclosure relates to an aerosol therapy device including: a housing; an aerosol generator, which is arranged in the housing; an air inlet, which is formed in the housing upstream of the aerosol generator; and an air outlet, which is formed in the housing downstream of the aerosol generator to administer the aerosol produced, wherein an air flow from the air inlet to the air outlet can be generated by a negative pressure at the air outlet, wherein the air flow flows around the aerosol generator, wherein a truncated-cone-shaped flow channel, the central axis of which extends in a curved manner, is arranged between the aerosol generator and the air outlet.

Abstract: A device, which is closable by a cap, for inhaling powdery substances, particularly of a medicinal kind, contained in capsules is displaced by a slider into an emptying position for the purpose of aspirating completely the content thereof. The air inlet for the mouthpiece channel is adjacent to and below the closed mouthpiece cap.

Abstract: A nebulizer and a method of breathing using the nebulizer is described. The nebulizer and breathing techniques are capable of delivering medicament into the sinus cavity of a user.

Abstract: A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.

Abstract: A wearable wrist inhaler includes a wristband having a first end and a second end configured for wear about a user's wrist. An inhaler unit is coupled to the wristband displaced from the first end and the second end, the inhaler unit including a housing having a plurality of walls defining an interior area and an outlet port in communication with the interior area. A watch assembly is positioned atop the housing of the inhaler unit, the watch assembly energized by a battery and includes a display configured to indicate a time of day. A dosage chamber including a medicament is positioned in the interior area of the housing. A dispensing assembly is communication with the inhaler medicament that is configured to dispense an individual portion of the medicament via the outlet port upon demand by a user.

Abstract: A nasal delivery device can include a nasal prong and an activation member. The nasal prong can comprises an opening at a top and bottom portion of the prong to allow for the passage of an aerosolized treatment agent through the nasal prong. The activation member can be positioned on the nasal delivery device at a location that is spaced apart from the subject's oral cavity when the nasal prong is received into the nostril of the subject. The activation member can be configured to detect a desired exhalation state of the subject and upon detection of the desired exhalation state, the activation member activates the delivery of the aerosolized treatment agent.

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

Abstract: A medication dispenser. The dispenser comprises a sensor for receiving biometric information from a user, a memory for storing a minimum dosing interval, a controller for determining whether the user is an authorized user, a belt having medication-carrying slots, a dose opening defined in an exterior surface of the dispenser, and a signaling device. The controller activates the signaling device and the sensor only when the minimum dosing interval has elapsed as measured from a last successful user authentication. The sensor is responsive to user biometric information provided any time after activation of the signaling device and the sensor, but not before activation of the signaling device and the sensor. After determining the use is an authorized user, a medication-carrying slot is aligned with the dose opening.

Abstract: Taught herein is a disposable breath actuated dry powder drug inhalation device having a powderized drug storage chamber with integral toroidal geometry and air flow pathways for entraining and breaking up powder aggregates prior to delivery to the patient. The toroidal chamber is fluidly connected by one or more air inlets directed in a non-tangent manner toward the powder to loft and set up an irregular-rotational flow pattern. Also, in fluid connection with the toroidal chamber is a centrally or near centrally located air and powder outlet consisting of one or more holes forming a grid in fluid connection with a channel providing a passageway for powder flow to the patient.

Abstract: Phospholipid based powders for drug delivery applications are disclosed. The powders comprise a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature of the particle compared to particles without the polyvalent cation. The powders are hollow and porous and are preferably administered via inhalation.

Abstract: A medicated module containing a second medicament is configured for removable attachment to the mouthpiece of an inhaler containing a first medicament such that a single inhalation by a user will deliver both medicaments to the user.

Abstract: A dry-powder inhaler including a body containing a dispersion chamber; a dispenser orifice through which the user inhales; a loading opening that receives a capsule containing a dose of dry powder for inhaling; and at least one movable portion that moves relative to the body between a first end position and a second end position; the dispersion chamber containing at least a portion of an empty capsule at the moment of inhalation, the at least one capsule portion swirling in the dispersion chamber during inhalation so as to disperse and/or break up the powder.

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation.

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

Abstract: A filtering powdered medicament inhaler comprising a base (1) and an upper base (2). The upper base (2) has arranged therein a separator (62), which is connected at the bottom to a pressure groove (63). The upper base (2) has arranged thereon a hollow tube exterior connector (10) matching a suction tube (131). The hollow tube (19a) and a cavity (9) on one side of the separator (62) are interconnected via conduit (18), or, the hollow tube (19a) is extended for about 8 centimeters to form a mouthpiece. The upper base (2) has arranged in the cavity (9) thereof a filter (121). The base (1) is provided with an external base cover (72) which covers a press-button (5a) so as to reduce air flow into the cavity (9). The medicament inhaling conduit of the inhaler is relatively sealed and allows for rapid entrainment of a sufficient dosage of powdered medicament.

Abstract: An apparatus (10) and method to aid in administering inhaled pharmaceutical aerosol to a patient is configured to maintain a tongue in proper position and offset the patients upper and lower jaws during aerosol delivery. An adjustable member (26) is provided adjacent a mouthpiece and at least partially surrounds and moves with respect to the body of the apparatus. The adjustable member has a step structured (32, 34) to impart a selected amount of mandibular advancement to a patient during aerosol delivery. A tongue depressor (40) which may be integrally formed with the adjustable member configured to prevent a tongue from occluding a flow of aerosol is also provided.

Abstract: A passive inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler includes an impaction element onto which the air stream can impact together with entrained inhalation formulation for better deagglomeration. Alternatively, the inhaler includes an oscillating and/or vibrating device for better de-agglomeration of the inhalation formulation. Alternatively or additionally, the inhaler includes one or two mixing means for generating swirls, preferably with opposite rotation directions.

Abstract: The disclosure relates to a medical dispenser, comprising an outlet and a plurality of sealed compartments containing medicament to be sequentially aligned with and dispensed through said outlet. Movement of an actuator sequentially causes mechanical energy to be built up and then released and converted into an indexing movement of the compartments. The disclosure also relates to an indexing method for a medical dispenser.

Abstract: A dose delivery device with a mouthpiece having an inlet, an outlet, and an air path extending between the inlet and the outlet. A dose chamber having an opening may hold a dose, e.g., for inhalation by a user. A disc element may be arranged to move between a closed position in which the disc element closes the opening of the dose chamber, and an open position in which the disc opens the dose chamber to permit introduction of the dose into the air path of the device. Movement of the disc element from the closed position to the open position may be in a direction away from the dose chamber (e.g., a puller may engage the disc element and pull the element away from the chamber) and may leave a substantial portion of the dose in the dose chamber.

Abstract: The present disclosure relates to a method for entraining in an airflow a medicament powder contained in a cavity having a cavity opening. Large airflow vortices are provided, for instance, by use of an obstacle in a flow passage, The airflow with large vortices is arranged to by-pass the cavity opening, thereby generating an eddy in the cavity which contributes to entraining the powder in said airflow. The present disclosure also relates to a medical dispenser, for instance an inhaler, in which the method may be performed.

Abstract: An apparatus includes a label configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia. The label further includes an electronic circuit system configured to output an electronic signal.

Abstract: A dry-powder inhaler (100; 200) having: a body (110; 210) forming a dispersion chamber (111; 211); a dispenser orifice (131; 231) through which the user inhales; a loading opening (121; 220) that receives a capsule (10) containing a dose of dry powder for inhaling; and capsule opening mechanism (140; 265) for opening a capsule inserted into said loading opening and emptying the dose of powder into said dispersion chamber. The body (110; 210), at least at one wall of said dispersion chamber, is made of a tinted transparent material that is adapted to filter UV rays, at least in part, and to make it possible to see the inside of the dispersion chamber while masking, at least in part, residues of powder that are stuck to the at least one wall of tinted transparent material.

Abstract: A device for inhalation of at least one air stream carrying a dose of medicament powder having a powder-containing cavity which opens into a flow passage. The flow passage is arranged to direct an inhalation air flow across the cavity opening. A circulating flow is thereby induced in the cavity by the phenomenon of shear driven cavity flow. Powder is entrained in the circulating flow and deaggregated before exiting the cavity and becoming entrained in the flow of air along the flow passage.

Abstract: A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.