Abstract: A fluidic coupler to engage a plurality of flow cells of a sensor device includes a body and a plurality of fluidics interfaces formed in the body. Each fluidic interface of the plurality of fluidics interfaces includes an opening, a first port in fluid communication with the opening, a second port, and a third port in fluidic communication with the second port.

Abstract: A method and device are used for administering a humidified aerosol to a patient interface by providing and guiding a first gas flow having a humidified aerosol, a second gas flow having humidified respiratory gases, and a liquid flow of a thermally balancing liquid, thermally balancing the first and second gas flow by parallel guiding the first and second gas flow such that the first and second gas flow are guided in a manner that they are at least partially surrounded by the liquid flow of the thermally balancing liquid, mixing the first and second gas flow to obtain enriched respiratory gases having the humidified aerosol, and administering the enriched respiratory gases to the patient interface. The method and the device avoid the administration of dry or re-dried powdered aerosols and unwanted accumulation of and blockage by powdered material. The device is useful in respiratory support of preterm infants.

Abstract: An apparatus includes a housing having a gas flow generator for generating a flow of breathing gas and a humidifier disposed therein having a chamber for housing a volume of water. The chamber has a top opening for providing the volume of water therein. The apparatus further includes a lid coupled to the housing that is movable between a first position wherein the lid covers the top opening and a second position wherein the lid does not cover the top opening. The apparatus also includes a passage which extends from a first end positioned and structured to receive the flow of breathing gas from the gas flow generator to an opposite second end positioned on the lid and structured to expel the flow of breathing gas into the chamber. An outlet for conveying the flow of breathing gas from the chamber out of the housing is positioned on the housing.

Abstract: An apparatus for humidifying a flow of breathable gas includes a water reservoir and a water reservoir dock forming a cavity structured and arranged to receive the water reservoir in an operative position. The water reservoir comprises a reservoir base including a cavity structured to hold a volume of water, the reservoir base including a main body and a thermally conductive portion provided to the main body. The thermally conductive portion comprises a combined layered arrangement including a metal plate and a thin film, the thin film comprising a non-metallic material and including a wall thickness of less than about 1 mm. The thin film is adapted to form at least a bottom interior surface of the water reservoir exposed to the volume of water, and the metal plate is adapted to form a bottom exterior surface of the water reservoir.

Abstract: A breathing assistance system for delivering a stream of heated, humidified gases to a user, comprising a humidifier unit which holds and heats a volume of water, and which in use receives a flow of gases from a gases source via an inlet port, the flow of gases passing through the humidifier and exiting via an exit port, the system further having a temperature sensor which measures the temperature of the gases exiting the humidifier unit, an ambient temperature sensor which measures the temperature of gases before they enter the humidifier unit, and a flow sensor which measures the flow rate of the gases stream, the system also having a controller which receives data from the temperature and flow sensors, and which determines a control output in response, the control output adjusting the power to the humidifier unit to achieve a desired output at the humidifier unit exit port.

Abstract: Devices and systems provide methods of detecting a severity change in respiratory insufficiency (RI) or chronic obstructive pulmonary disease (COPD) condition of a patient. In an example embodiment, a detection monitoring device determines one or more severity change indicators based on a measure of supplied pressure or other representative measure determined by the device. The supplied pressure may optionally be determined during pressure treatment that satisfies a target ventilation. The supplied pressure or representative data may be compared to one or more thresholds that are selected to represent a change in the condition of the RI or COPD patient such as an exacerbation of a prior condition. Results of the comparisons may trigger one or more warnings or messages to notify a patient or physician of a pending change to the patient's RI or COPD condition so that the patient may more immediately seek medical attention to treat the condition.

Abstract: The invention relates to a method of determining water level in a humidifier chamber that is part of a humidified gases delivery apparatus and system. The method comprising the steps of delivering power to a heater plate, varying the power delivered to the heater plate, measuring the rate of change of temperature and determining the level of water based on the heating characteristics of the volume of water within the chamber, in particular determining the level of water within the chamber based on the rate of change of temperature and the supplied power.

Abstract: A humidifying system is configured to humidify pressurized breathable gas. The humidifying system includes a housing configured to couple to a blower that is adapted to supply pressurized breathable gas to provide continuous positive airway pressure (CPAP) treatment to a patient. The humidifying system also includes a tub adapted to hold a volume of water and a heater element to heat the volume of water. A controller is configured to select a humidity profile from a plurality of humidity profiles based on ambient conditions that occurred during a previous treatment session. Each of the plurality of humidity profiles presets a respective target humidity level of the pressurized breathable gas for a respective treatment session.

Abstract: Apparatus and methods for delivering humidified breathing gas to a patient are provided. The apparatus includes a humidification system configured to deliver humidified breathing gas to a patient. The humidification system includes a vapor transfer unit and a base unit. The vapor transfer unit includes a liquid passage, a breathing gas passage, and a vapor transfer device positioned to transfer vapor to the breathing gas passage from the liquid passage. The base unit includes a base unit that releasably engages the vapor transfer unit to enable reuse of the base unit and selective disposal of the vapor transfer unit. The liquid passage is not coupled to the base unit for liquid flow therebetween when the vapor transfer unit is received by the base unit.

Abstract: Apparatus and methods for delivering humidified breathing gas to a patient a provided. The apparatus includes a humidification system configured to deliver humidified breathing gas to a patient. The humidification system includes a vapor transfer unit and a base unit The vapor transfer unit includes a liquid passage, a breathing gas passage, and a vapor transfer device positioned to transfer vapor to the breathing gas passage from the liquid passage. The base unit includes a base unit that releasably engages the vapor transfer unit to enable reuse of the base unit and selective disposal of the vapor transfer unit. The liquid passage is not coupled to the base unit for liquid flow therebetween when the vapor transfer unit is received, by the base unit.

Abstract: A humidification chamber having suspension type float, the humidification chamber comprises a shell body, a water level control valve and a heated plate; the shell body has a water inlet, a gas inlet and a gas outlet; the water level control valve is provided with a position limiting element, a float and a sealing sheet; wherein the sealing sheet is disposed on a top end of the float, the heated plate is used for sealing the shell body to form a chamber space; when a liquid enters into the chamber space by a water inlet hole of the water inlet, the float will rise to comply with the water level increasing; when the sealing sheet contacts the water inlet hole of the water inlet, the sealing sheet can block the water inlet hole of the water inlet; when the water level of the chamber space is fell down, the position limiting element can prevent a bottom of the float from contacting the heated plate.

Abstract: Vaporization devices, systems, and methods with automated thermal profile control are disclosed. Thermal profile information for a particular vaporizable material is encoded to control the operation of the vaporizer. The thermal profile is defined by a plurality of set points specified by power/temperature setting for a specified time. The thermal profile may be configured to be applied during a single or multiple inhalations. A thermal profile recipe code containing thermal profile information associated with the vaporizer cartridge and/or vaporizable material contained therein may be used to control the thermal profile. The thermal profile information may be automatically read by or communicated to the vaporizer and used thereby to automatically control the vaporizer heating element to implement the desired thermal profile associated with the vaporization material.

Abstract: A breathing assistance apparatus has a main body. A humidification compartment is defined within the main body and is adapted to receive a humidification chamber. A flow generator is positioned within the main body. The flow generator and the humidification compartment are fluidly connected and a liquid containment compartment is interposed between the flow generator and the humidification compartment. The liquid containment compartment is fluidly connected to both the flow generator and the humidification compartment.

Abstract: A housing and method of using the same is configured and coupled to an aerosol generator which delivers aerosol into an oxygen stream transporting both to a patient via a nasal cannula, in a way to minimize condensation at low liters per minute flow rate.

Abstract: An assembly for evaporating a volatile material is described, the assembly comprising a device and a refill which are detachable from one another: wherein the device comprises a magnetic induction coil configured to operate with an alternating current passed therethrough at a frequency of between substantially 20 KHz to substantially 500 KHz and one or more volatile fluid emanation channels containing at least one piece of heat-conducting, non-magnetic metal foil and/or deposited heat-conducting, non-magnetic metal; and wherein the refill comprises at least one magnetic susceptor having a coercivity of substantially 50 ampere/meter (HC) to substantially 1500 ampere/meter (HC) and a substantially liquid-tight sealed reservoir containing the volatile material; wherein, in use, the magnetic susceptor(s) is arranged to heat the material predominately by magnetic hysteresis when the magnetic susceptor(s) is at least partially positioned in the induced magnetic field generated, in use, when said alternating current

Abstract: A removable replaceable cartridge for use with a liquid diffusing device. The cartridge includes a venturi, a conduit extending to the venturi, a mixing area and an outlet path for atomizing and dispersing a liquid within the cartridge. A diffusion device including a removable replaceable cartridge received within a housing. The housing includes a source of compressed gas which is directed into the cartridge. A venturi head with a unitary body for use with a diffusion device.

Abstract: A breast pump device for pumping breast milk is disclosed. The breast pump device may include a breast shield for receiving a breast, a collection container for receiving breast milk, a tubing connecting the breast shield to the collection container, and a pump connected to the collection container, configured to draw breast milk from the breast shield, through the tubing, and into the collection container. The breast shield may include a channel extending from an interior portion of the breast shield located near a nipple of the breast to an exterior portion of the breast shield. The various components of the breast pump device may be made out of antimicrobial materials. One or more sensors and/or computing devices may be incorporated to measure the amount of milk produced, monitor temperature of the milk, and provide alerts regarding pumping schedules.

Abstract: The present disclosure relates to aerosol delivery devices, methods of forming such devices, and elements of such devices. In some embodiments, the present disclosure provides devices configured for vaporization of an aerosol precursor composition that is stored in and/or transported to a heater by a porous monolith, which can be, for example, a porous glass or a porous ceramic. A heater can be in a heating arrangement with an external portion of the porous monolith or can be substantially internal to the porous monolith.

Abstract: A method of automatically controlling the humidity of a gas stream of a pressure support system (50) during use of the system is provided. The method includes receiving a first humidification level, and controlling operation of a humidifier (68) based on the first humidification level and at least one of: (i) one or more environmental parameters relating to environmental conditions around the pressure support system, (ii) one or more gas stream parameters relating to a gas stream output by the pressure support system to a patient circuit (56, 58), (iii) one or more respiratory demand parameters of a user of the pressure support system, and (iv) one or more operating parameters of the pressure support system that effect a flow rate that is generated by a pressure generating system (52, 60) of the pressure support system.

Abstract: A respiratory assistance apparatus includes a flow generator and a humidifier. The humidifier includes a humidification chamber. The humidification chamber comprises a water tub that is configured to receive a volume of water. A lid is hingedly coupled to the water tub for enclosing a volume contained within the water tub.

Abstract: An improvement for existing breathing therapy machines which seeks the optimum therapy pressure using an auto-adjust algorithm.

Abstract: Some embodiments provide for humidifier control systems and methods configured to adjust power to a heater plate in a surgical humidifier to account for changes in flow rate to provide a consistent output, to provide functionality for different modes of use, and to provide accurate control over temperature and/or humidity at relatively low flows. The humidifier control system can receive a flow rate reading and determine a power requirement corresponding to the received flow rate reading, wherein the power requirement is one of a plurality of set points which correspond to ranges of flow rates. The humidifier control system can determine a mode of use based at least in part on the flow rate reading. The humidifier control system can provide electrical power to the heater plate according to the power requirement and/or the mode of use.

Abstract: An air delivery conduit (620) includes first (621) and second (622) conduit portions that cooperate to form the conduit, each conduit portion including an inner layer of a film laminate (650) that forms an interior surface of the conduit and an outer layer of a textile (655) that forms an exterior surface of the conduit.

Abstract: An aqueous solution that is useful for helping to increase body temperature in people with chronic low body temperature, as well as people who suffer from cold hands and feet, includes a combination of ginseng, cinnamon, ginger, and jasmine tea. The body temperature raising solution may be in the form of a beverage and include a sweetener, such as honey, to improve the taste thereof. The body temperature raising solution is formulated by steeping leaves of the jasmine tea in a host liquid, suspending predetermined amounts of the ginseng, cinnamon, ginger, and honey into the host liquid, and storing the combination in an airtight container.

Abstract: An arrangement and method for guiding expired gas flow in a breathing circuit through a housing assembly for removing an undesired gas component is disclosed herein, The housing assembly includes a first port and a second port, one of the ports receiving the flow and another discharging the flow. The arrangement includes a gas routing device in flow communication with the breathing circuit and the housing assembly. The routing device is provided with at least two different route options. According to a first option the gas is guided to the first port and through the housing assembly to the second port and to the gas routing device for guiding for the inspiration. According to a second option the gas is guided to the second port and through the housing assembly to the first port and to the gas routing device for guiding for the inspiration.

Abstract: A breathing assistance apparatus and method of controlling a breathing assistance apparatus is disclosed. Particularly, the breathing assistance apparatus is controlled such that it has a drying cycle to enable drying of the tubing that supplies gases to a user and prevent the harboring of pathogens within the tube. The drying cycle is preferably operated automatically by internal controllers in the apparatus. However, it may be manually activated by pressing a button on the apparatus. The drying cycle is preferably activated at the end of a user's treatment session.

Abstract: A CPAP device includes a humidifier including humidifier tub having a heat conducting base plate; and a cradle to support the humidifier tub in an operative position. The cradle may also support a flow generator in operative relation to the humidifier tub. The cradle includes a heater plate in communication with the heat conducting base plate of the humidifier tub in use. The cradle further includes a retaining mechanism to retain the humidifier tub in the cradle, the retaining mechanism being structured to force the base plate into engagement with the heater plate. The humidifier and/or flow generator may include various features to manage inadvertent back-spill of water from the humidifier to the flow generator.

Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10? thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method comprises: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

Abstract: A gas apparatus for use in a medical procedure may include a housing, a heater, a port, and a dispensing device. The housing defines a chamber having a gas inlet and a gas outlet. The heater warms a gas flowing through the chamber. The port is positioned in fluid communication with the chamber. The dispensing device is inserted within the port for delivering water in aerosol form to warmed gas as it exits the gas outlet.

Abstract: Apparatus and methods for delivering humidified breathing gas to a patient are provided. The apparatus includes a humidification system configured to deliver humidified breathing gas to a patient. The humidification system includes a vapor transfer unit and a base unit. The vapor transfer unit includes a liquid passage, a breathing gas passage, and a vapor transfer device positioned to transfer vapor to the breathing gas passage from the liquid passage. The base unit includes a base unit that releasably engages the vapor transfer unit to enable reuse of the base unit and selective disposal of the vapor transfer unit. The liquid passage is not coupled to the base unit for liquid flow therebetween when the vapor transfer unit is received by the base unit.

Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.

Abstract: The breathing assistance apparatus of the present invention includes a manifold that is provided with or retrofittable to gases supply and humidifying devices. The manifold allows gases from an oxygen concentrator to be combined with the flow through a gases supply and humidifying device, most usually air The combined output of oxygen and other breathing gases (air) is then humidified. The breathing assistance apparatus and manifold of the present invention provides a safe method to add oxygen to the input air stream of a gases supply and humidifying device and reduces the amount of accumulation of oxygen within the gases supply device, reducing fire risk should sparking occur within the device.

Abstract: The invention provides a method of selecting a nebulizer device to be used to deliver a vaccine comprising selecting a nebulizer capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/?0.2 ?m (ii) Dv50: 5.0+/?0.5 ?m (iii) Dv90: 10.0+/?1.0 ?m (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 ?m This allows the selection of, for example, commercially available nebulizers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulizers. Nebulizers identified by the methods of the invention are also claimed.

Abstract: The present invention is antibiotic compositions, ventilator based systems and methods relating to ventilator-associated pneumonia (VAP) and ventilator-associated tracheal (VAT) bronchitis. Antibiotic combinations of fosfomycin and an aminoglycoside, preferably amikacin, are administered via an in-line nebulizer within the airway of the ventilator. Humidified conditions create an improved aerosol mist to treat VAP and VAT.

Abstract: A water filled unitary flexible pouch for use with a heating element for delivering humidified air to a user, comprising a disposable pouch formed from a first and a second flexible polymer sheet sealed to the first flexible polymer sheet, wherein the second flexible polymer sheet comprises a flexible metalized area adapted to contact the heating element. A premeasured amount of distilled water is in the disposable pouch in contact with the flexible metalized area, and forms vaporized water when the flexible metalized area contacts the heating element. An integral inlet port is used to flow continuous pressurized air into the disposable pouch at a titrated pressure ranging from about 4 centimeters of water to about 30 centimeters of water, and an integral outlet port is used to flow vaporized water and pressurized air from the disposable pouch at a pressure up to about 30 centimeters of water.

Abstract: The present invention is antibiotic compositions, ventilator-based systems and methods relating to ventilator-associated pneumonia (VAP) and ventilator-associated tracheal (VAT) bronchitis. Antibiotic combinations of fosfomycin and an aminoglycoside, preferably amikacin, are administered via an inline nebulizer within the airway of the ventilator. Humidified conditions create an improved aerosol mist to treat VAP and VAT.

Abstract: Systems and methods are provided for humidifying ventilation gas. Systems and methods may include a nasal interface apparatus for receiving ventilation gas from gas delivery tubing and for humidifying ventilation gas. The nasal interface apparatus may have one or more channels within the nasal interface to deliver gas from a gas delivery circuit to a patient's nose; one or more structures in fluid communication with the one or more channels to direct ventilation gas to the patient's nose; and a hygroscopic material within the nasal interface in the flow path of the ventilation gas.

Abstract: The present invention provides an apparatus and methods for the administration of positive airway pressure therapies. The apparatus can include a housing, a blower and a mask. The housing is configured to be stably secured on the head of a patient. The blower is secured relative to the housing. A mask in fluid communication with the blower is configured to communicate pressurized air produced at least in part by the blower to the airways of a user.

Abstract: A personal vapor inhaling unit is disclosed. An electronic flameless vapor inhaler unit that may simulate a cigarette has a cavity that receives a cartridge in the distal end of the inhaler unit. The cartridge brings a substance to be vaporized in contact with a wick. When the unit is activated, and the user provides suction, the substance to be vaporized is drawn out of the cartridge, through the wick, and is atomized by the wick into a cavity containing a heating element. The heating element vaporizes the atomized substance. The vapors then continue to be pulled by the user through a mouthpiece and mouthpiece cover where they may be inhaled.

Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

Abstract: A humidification canister for humidifying a breathing gas, the humidification canister includes a fluid supply configured to supply a fluid and a first gas flow path in fluid communication with the fluid supply. A first gas flow path is configured to humidify the breathing gas with the fluid. A second gas flow path at least partially surrounds the first gas flow path. A method of insulating a breathing gas in a humidification canister using a gas is also disclosed.

Abstract: An apparatus for supplying a respiratory gas includes a conveyor device for conveying the respiratory gas, a conduit for feeding the respiratory gas conveyed by the conveyor device to a person, and a humidification device for humidifying the respiratory gas. A sensor device is configured to generate a signal indicative of the respiratory gas humidity and a control device is configured to control the humidification device with regard to the signal which is generated by the sensor device. A method of supplying a respiratory gas to a patient, in which the respiratory gas is introduced by means of a conveyor device into the conduit leading to the patient and is humidified, includes operating the conveyor device so that a respiratory gas pressure which is above ambient pressure is provided in the conduit, and adjusting the humidity on the basis of signals indicative of the relative and/or absolute humidity of the respiratory gas generated by the sensor device.

Abstract: The present invention is to provide a gas mist inhaler, in which a gas introduction part of heightening pressure for supplying a gas mist is made integral with a gas mist generator in order to realize a simplified structure and cost reduction.

Abstract: The present invention is antibiotic compositions, ventilator-based systems and methods relating to ventilator-associated pneumonia (VAP) and ventilator-associated tracheal (VAT) bronchitis. Antibiotic combinations of fosfomycin and an aminoglycoside, preferably amikacin, are administered via an inline nebulizer within the airway of the ventilator. Humidified conditions create an improved aerosol mist to treat VAP and VAT.

Abstract: A personal airway humidification and oxygen-enrichment apparatus includes at least two membranes adapted to produce a conditioned gas. At least a first of the membranes is adapted to produce a first gas and at least a second of the membranes is adapted to produce a second gas having an oxygen content higher than the first gas. The conditioned gas includes the first gas, the second gas, or a combination thereof from the membranes. The membranes are adapted to produce the first gas and the second gas so that the conditioned gas contains gaseous water to about 100 percent saturation. The apparatus includes means for delivering water to the membranes, means for delivering an initial gas to the membranes, and a delivery hose adapted to receive the conditioned gas from one or more of the membranes and deliver the conditioned gas to a delivery device.

Abstract: A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.

Abstract: The present inventions provide respiratory therapy apparatus that introduce water into the pressurized air delivered to a user during various positive airway pressure therapies and corresponding methods. The respiratory therapy apparatus may be configured to administer one or more positive airway pressure therapies, including: continuous positive airway pressure therapy (CPAP), bi-level positive airway pressure therapy (BPAP), auto positive airway pressure therapy (autoPAP), proportional positive airway pressure therapy (PPAP), and/or other positive airway pressure therapies. The respiratory therapy apparatus may include a user interface that defines an interface passage to communicate pressurized air to the user for inhalation and a humidifier that introduces water into the pressurized air generally at the interface passage. Methods according to the present inventions may include introducing water into the interface passage at one or more humidifier ports disposed about the interface passage.

Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.

Abstract: The present invention is antibiotic compositions, ventilator based systems and methods relating to ventilator-associated pneumonia (VAP) and ventilator-associated tracheal (VAT) bronchitis. Antibiotic combinations of fosfomycin and an aminoglycoside, preferably amikacin, are administered via an in-line nebulizer within the airway of the ventilator. Humidified conditions create an improved aerosol mist to treat VAP and VAT.

Abstract: An apparatus for delivering humidified gases has a connection manifold adapted to connect with inlet and outlet ports of a slide on water chamber in a single slide on motion. Connection of the gases inlet and gases outlet ports as well as any additional electrical and/or pneumatic connections are all made in the same slide on motion. The water chamber may include inwardly extending elongate extension tubes with one of the extension tubes having an air bleed aperture to aid filling of the chamber.