Abstract: A dry powder inhaler (1) is to be made available, with which a particle size and particle size distribution preferred for inhalation are to be achieved and by means of which as high a line particle fraction as possible is to be realized. This is achieved by means of a dry powder inhaler (1 ) that is characterized in that provided in the inhaler (1) is a nozzle (10) through which the aerosol (9) flows before leaving the inhaler (1).

Abstract: An inhaler for inhaling powdered pharmaceutical compositions from capsules includes: a lower part; a plate which can be latched to the lower part and with which the lower part can be closed off; a capsule holder for receiving the capsules, this holder being adapted to be lowered into the lower part; a mouthpiece latchable to the plate; a lid which covers the mouthpiece in a closed position and latches it by means of a closure element, the lower part, the plate, the mouthpiece and the lid being hinged together by means of a single joint; and an actuating member which can be moved out a resting position and thereby interacts with at least one pin which can be made to pierce the capsule holder.

Abstract: The invention relates to a dispenser (1) for pulverulent substances (30), in particular medicaments, from a blister pack (25), dome-shaped cavities (26) of which that are disposed on a base layer (28) can, by movement in a dispenser housing (4), be brought step by step into an emptying position, in which they can be opened by means of a needle (31) and can be emptied by a suction air stream (a) leading to a mouthpiece (6). To achieve optimum emptying of the cavities, it is proposed that the needle (31) passes crosswise through both lateral walls of the dome (29) of the cavities (preferably parallel to the base layer 28) in order to form a through path to the mouthpiece for suction air.

Abstract: Dosage forms containing pharmaceutical compositions for use in devices to produce a spray or mist delivery of the compositions include dosage blister compartments and a dispensing blister compartment, wherein crushing of the compartments delivers the compositions in a desired spray pattern. Certain dosage forms include a plurality of dosage chambers each containing a component or a portion of a pharmaceutical composition, the contents of which are mixed or combined just prior to or during administration.

Abstract: An aerosolization apparatus comprises a body defining an inlet opening, an outlet opening, and an aerosolization chamber between the inlet opening and the outlet opening. The aerosolization chamber is adapted to receive an elongated receptacle, such as a capsule, containing a pharmaceutical formulation. The elongated receptacle rotates end-over-end about an axis substantially orthogonal to an axis passing through the outlet opening when air or gas flows through the body. In another version, the elongated receptacle rotates end-over-end about an axis substantially orthogonal to an inhalation direction.

Abstract: A fluid dispenser device including at least one individual reservoir (21) containing a single dose of fluid, opening means (40) being provided for opening an individual reservoir (21) each time the device is actuated, said opening means (40) comprising perforator and/or cutter means (41) and movable support means (50), said movable support means (50) being adapted to displace an individual reservoir (21) against said perforator and/or cutter means (41) on each actuation.

Abstract: A kit for coupling a container holding a liquid to a fluid path of a humidifier is disclosed. The kit includes a spike configured to pierce the container and to pass the liquid from the container to a vent through a tube. The vent is configured to vent gas from the liquid while retaining the liquid. The vent has a vent body including an inlet configured for coupling to the tube to receive the liquid from the tube and an outlet configured to pass the liquid to the humidifier. A cap opening is positioned to vent the gas. A filter is positioned over the cap opening to prevent the escape of the liquid therethrough. A cap is coupled to the vent body over the cap opening and has at least one opening therein to allow passage of gas from the opening to atmosphere.

Abstract: An apparatus, system and method for transferring a liquid, such as a liquid anesthetic, from a reservoir to a machine while minimizing the release of a liquid to the surrounding environment. The apparatus may include a device having a reservoir; and a self-sealing membrane attached to the reservoir. The system may include a device having a reservoir and a self-sealing membrane attached to the reservoir; and a vaporizer having a needle for extending through the self-sealing membrane when the device is mated with the vaporizer.

Abstract: A fluid dispenser device comprising a body (10), said device further comprising: an elongate flexible strip (20) supporting a plurality of reservoirs (21) each containing a dose of fluid or powder; reservoir-opening means (30) for opening a respective reservoir on each actuation; first displacement means (40) for causing said flexible strip (20) to advance before and/or during and/or after each actuation, so as to bring a full reservoir into register with said reservoir-opening means; and second displacement means (45) for displacing a full reservoir (21) against said opening means (30) each time the device is actuated, the leading end (25) of said flexible strip (20), in the advance direction of said strip, being fastened to a receiver element (50) that is rotatably mounted, said receiver element (50) being fastened to a loaded spring (500) that is adapted to exert a force on said receiver element (50) so as to urge it to turn, such that said receiver (50) exerts a traction force on said elongate strip (20),

Abstract: An inhaler (1) device for inhalation of a medicament from a pierceable capsule (10) comprises a housing (2) for receiving a medicament, capsule, closure means (3) for closing the housing, said closure means being moveable relative to the housing; piercing means (7) suitable for piercing a medicament capsule; wherein movement of the closure means relative to the housing causes movement of the piercing means, and wherein the device comprises an air inlet (71) and an air outlet (72) defining an inhalation passage therebetween, the passage comprising one or more vents (70).

Abstract: An evaporation element for liquids, in particular aqueous solutions, has a first reservoir for storing the liquid that is to be evaporated, a second reservoir, which is separated from the first reservoir by a sheet and contains a reagent that in contact with the liquid that is to be evaporated carries out an exothermic chemical reaction, and an opening element which, on actuation, perforates the sheet and in this way brings the reagent into contact with the liquid that is to be evaporated.

Abstract: Dry powder inhalers for dispensing pharmaceutical grade formulations of inhalable dry powder include: an inhaler housing having a mouthpiece associated therewith; and a slidably extendable forward member that is movable between retracted and extended positions, held by the inhaler housing adjacent the mouthpiece. In the extended position, the forward member extends outward a distance beyond a forwardmost portion of the mouthpiece, and in the retracted position, a forwardmost portion of the forward member is positioned rearward of the forwardmost portion of the mouthpiece with an access portion of the mouthpiece accessible by a user.

Abstract: A device for containing a volatile anesthetic and an anesthetic agent delivery system. The device may include a bottle closure, which may be attached to an anesthetic bottle until it is time for the anesthetic to be transferred to a vaporizer. A membrane may be used to seal the opening in order to prevent the anesthetic from leaving the reservoir until it is desired to fill the vaporizer. In order to protect the membrane a cap and a cap support may be placed on the reservoir so as to cover the membrane. The container may further include a connecting surface on the cap support or the reservoir, the connecting surface being connectable to a vaporizer. The system includes a vaporizer having a side slotted tube needle that is able to pierce the membrane and through which the liquid anesthetic agent and/or vapor may pass from the reservoir to the vaporizer. A method for transferring a liquid anesthetic from a container to a vaporizer.

Abstract: A vaporization system for an inhalable substance includes a sealed cartridge. The sealed cartridge contains the chemical solution to be vaporized, a heating element which vaporizes the solution, and a wicking material for retaining the solution and bringing it into contact with the heating element through capillary action. The sealed cartridge may be disposable, having inexpensive elements so the cartridge can be replaced with little cost. Alternatively the sealed cartridge may be fully integrated with other components into a base unit, which may be disposable or may include a refill port which allows a user to refill the sealed cartridge with solution once the contained solution has been fully vaporized. A power source connects to the heating element and is activated by a switch that may be a breath detector. A disposable mouthpiece may be connected to the cartridge. The mouthpiece has an airway through which the vaporized solution is inhaled.

Abstract: A medicament container and a method of manufacturing the container housing at least one individual dose of medicament using a carrier having first and second opposing faces and through walls defining a through hole extending between the first and second opposing faces, the method including inserting the carrier into a mould having an element for protrusion into the through hole from the first face so as to define with the through walls a generally cup-shaped space, filling the generally cup-shaped space with a mould material so as to form a generally cup-shaped insert in the through hole, removing the carrier and insert from the mould, depositing an individual dose of medicament in the generally cup-shaped insert, and sealing the medicament and insert in the through hole by sealing first and second sheets respectively with the first and second faces.

Abstract: A delivery device, e.g. an inhaler, comprises a rotatable metering member adapted to dispense a measured amount of material, a material delivery passage and a material delivery orifice and at least one actuator member adapted to move the metering member from a material retaining position to a material dispensing position. In a magazine comprising a plurality of metering members, the actuator and metering members may operate in a radial direction. A plurality of rotatable magazines may be utilized in the delivery device. The delivery device may be used to deliver a single or a combination therapy.

Abstract: A delivery device, e.g. an inhaler, comprises a rotatable metering member adapted to dispense a measured amount of material, a material delivery passage and a material delivery orifice and at least one actuator member adapted to move the metering member from a material retaining position to a material dispensing position. In a magazine comprising a plurality of metering members, the actuator and metering members may operate in a radial direction. A plurality of rotatable magazines may be utilized in the delivery device. The delivery device may be used to deliver a single or a combination therapy.

Abstract: An inhaler for delivery of a powder-form inhalation formulation from a blister strip has a plurality of blister pockets and uses a pivotable mouthpiece cover to move the blister strip onward.

Abstract: An aerosolization apparatus comprises a housing defining a chamber having a plurality of air inlets. The chamber contains an aersolizable pharmaceutical formulation or is sized to receive a receptacle which contains an aerosolizable pharmaceutical formulation. A shield covers at least one of the air inlets or a portion of at least one of the air inlets. The shield prevents blockage of the air inlet by a user grasping the apparatus and inadvertently covering the air inlet. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the receptacle.

Abstract: An apparatus and method for the self-administration of a plurality of doses of an intranasal liquid pharmaceutical composition, including opioid analgesics, that includes a drug delivery device containing a plurality of sealed vials, each vial containing a predetermined volume of the pharmaceutical composition, a pump assembly for conveying the liquid pharmaceutical composition from the interior of the vial and discharging it as a nasal spray in response to manual activation by the patient, and programmable means for sequentially advancing a vial to the ready position after passage of a prescribed time interval following the last activation of the delivery device.

Abstract: Disclosed is an inhaler for administering a medicament in the form of inhalable substances, substance formulations, or substance mixtures, especially in the form of a powder. Said inhaler comprises a housing (1) which is provided with an interior (18) for accommodating at least one capsule that is filled with the medicament. The housing (1) is coupled to a mouthpiece (5) while an actuator (12) encompassing at least one needle (13) is mounted so as to be movable towards the housing in order to open the capsule. The mouthpiece (5) is effectively connected to the actuator (12) in such a way that the needle (13) of the actuator (12) does not extend into the interior (18) for 16 puncturing the capsule in an operational position of the mouthpiece (5).

Abstract: An inhaler is disclosed. It comprises a housing to receive an elongate strip of blisters each containing a dose of medicament and being sequentially movable into alignment with means for breaching a blister to enable a user to inhale said dose contained therein. The device comprises an unused and a used blister compartment separated by a wall which may be moulded integrally with the housing of the device.

Abstract: A medicament delivery device for administering a medicament to a user includes a medicament reservoir and an entrance port and an exit port and a gas chamber disposed adjacent the entrance port. The device includes a pressurizing mechanism to pressurize the gas chamber. The device also contains frangible membranes and may include a piercing member. In use, the frangible membranes in the device are responsive to pressure in the gas chamber and are either pierced or burst to allow gas to flow through the entrance port and the reservoir and to carry the medicament through the exit port.

Abstract: An aerosolization device comprises a chamber adapted to contain a powder pharmaceutical formulation, a lid at least partially covering the chamber, at least one piercing element forcible through the lid to provide access to the powder pharmaceutical formulation, and a shapeable surface extending from the chamber, the shapeable surface being adapted to undergo a shape change to form a conduit. The powder pharmaceutical formulation may be extracted from the chamber by a user inhaling through the conduit. In another version, the lid is removable from the chamber without the need for a piercing element.

Abstract: The invention relates to a medicament dispensing device, particularly a multi-dose powder inhaler, a medicament magazine thereof, and a method of removing a medicament from the medicament magazine as depicted in exemplary FIG. 1. The inhaler has a mouthpiece (9) and an air channel (4) connected thereto, as well as a medicament magazine with at least one medicament chamber containing a powdered medicament. A drive current is produced in the air channel, while a vacuum flow (5?) can be produced by the drive current and a constriction formed in the air channel. This narrowest part of the air channel that produces the vacuum flow is connected to a removal opening (2) which communicates with a control opening (3), in order to form an emptying current through the control opening via the removal opening. In a preferred embodiment the at least one medicament chamber including the control opening, the removal opening and a fill opening are housing in the one-piece medicament magazine.

Abstract: The invention relates to a medicament magazine with a plurality of doses of medicament, wherein the magazine is formed from a single foil strip in which pouches (2) for holding a medicament are formed. The foil strip comprises for transporting the strip openings (4) on at least one side for the engagement of transporting pins. The foil strip has a certain width in the region of the pouches, which is less than the width of the foil in other regions, and the openings are arranged in this broader part of the foil strip. The invention also relates to a method and a device for opening a medicament magazine of this kind, the device preferably being constructed as a segmented wheel.

Abstract: The present invention includes dry powder inhalers for dispensing and/or holding inhalant formulated dry powder substances and associated fabrication and dispensing methods that can employ an amplitude modulated non-linear signal comprising a plurality of superimposed frequencies, the frequencies corresponding to a priori flow characteristic frequencies of the dry powder being dispensed. The present invention also includes pocket-sized inhalers with an elastomeric flexible pivoting cover.

Abstract: An aerosolization apparatus comprises a housing defining a chamber having an air inlet and an air outlet, wherein the chamber is sized to receive a capsule containing a pharmaceutical formulation. A puncturing member is moveable within the chamber to contact the capsule and to provide an opening in the capsule, and a feedback mechanism provides an indication, such as a tactile indication, to a user when the puncturing member has been moved to a position where it provides the opening into the capsule. When air flows through the inlet, the pharmaceutical formulation is aerosolized and the aerosolized pharmaceutical formulation is delivered through the outlet.

Abstract: A blister piercing element for puncturing the Hd of a blister containing a dose of medicament for inhalation by a user is disclosed. The piercing element comprising an outlet opening for the passage of medicament entrained in an airflow out of the blister and, a piercing head extending beyond and overhanging the opening that cuts a flap in a lid of a blister and pushes it away from the opening during insertion.

Abstract: A liquid medication cartridge includes an accommodating portion for accommodating a liquid medication; a liquid discharge portion having a discharge port for discharging the liquid medication by using an ink jet technique, a communicating member for establishing communication between the accommodating portion and the liquid discharge portion and a filling member for filling the liquid discharge portion with the liquid medication.

Abstract: Methods for administering medical gases are disclosed including providing the medical gas in compressed gas cartridges containing an amount of the medical gas preferably corresponding substantially to a unit dose of the medical gas and providing a patient with means to access the medical gas from the gas cartridge upon need therefor. Apparatus for administering medical gases is also disclosed including a housing, a cassette associated with the housing containing at least one compressed gas cartridge preferably containing at least an amount of the medical gas substantially as required for a single dose and a patient supply interface to provide the medical gas to the patient.

Abstract: A conventional respiratory nebulizer has an emergency medication dose storage system conveniently useable in an emergency to deliver the stored medication dose directly to the nebulizing chamber quickly, reliably, and with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication.

Abstract: A dry powder inhaler including a housing having a mouthpiece and a delivery passageway connected to the mouthpiece, a magazine positioned within the housing and including a plurality of reservoirs for holding doses of dry powder, and wherein the magazine is movable within the housing so that the reservoirs are sequentially positioned within the delivery passageway of the housing upon movement of the magazine, a cover connected to the housing and movable to open and close the mouthpiece of the housing, and a rake connected to the cover, extending into the housing and engageable with the magazine so that, upon the cover being moved to open the mouthpiece, the rake moves the magazine and causes one of the reservoirs of the magazine to be positioned within the delivery passageway.

Abstract: The subject matter of the invention is a capsule, in particular for the packaging of inhalation formulations, in which at least one cavity is enclosed by a wall, characterized in that at least one portion of the wall has a polymer composition that contains at least one adsorbent, as well as said capsule's preferred use. Furthermore an inhaler and secondary packaging containing at least one such capsule are also described.

Abstract: An inhalator composed of a main body affording an inhalation conduit; a second body exhibiting a housing, into which a capsule can be at least partially inserted; the second body being rotatably coupled with the main body, and being able to rotate from an open position, in which the housing is accessible from outside for insertion of a capsule, and a closed position, in which the housing is in communication with the inhalation conduit; means for cutting off a portion of a capsule which projects from the housing during rotation of the second body from the open position to the closed position.

Abstract: A dispensing device and a storage device for dispensing a formulation as a spray. The storage device has multiple separate and pre-metered doses of the formulation in receptacles or cavities. In order to allow a very compact arrangement, the receptacles or cavities are arranged in a first group and a second group axially offset, and preferably, forming a double ring arrangement, and the storage device is rotatable and axially moveable for dispensing the doses one after the other.

Abstract: The invention provides an inhaler of the non-reservoir kind (i.e. one which operates by dispensing individually packaged doses) characterised by the feature that a moisture-proof barrier—which may optionally comprise substantially or partly an external region of the inhaler-encloses the dose-storage region of the inhaler without enclosing the doses individually, and incorporates a similarly moisture-proof aperture through which the medicament doses can, in use, be individually dispensed. The invention also provides a method of filling such an inhaler.

Abstract: Dry powder inhalers with a multi-dose dry powder package for dispensing pharmaceutical grade formulations of inhalable dry powder, include: (a) a blister package comprising a plurality of spaced apart sealed blisters thereon, each blister having a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein; (b) a movable blade cartridge holding a blade at a forward portion thereof; and (c) an extendable mouthpiece attached to the movable blade cartridge. In operation, a user pulls the mouthpiece outward and then pushes the mouthpiece inward to cause the blister package to advance to position a blister in a selected dispensing position in the inhaler and to cause the blade cartridge to move the blade across a blister ceiling held in the dispensing position in the inhaler to thereby open the blister held in the dispensing position.

Abstract: The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position.

Abstract: An inhalation device (1) comprising two or more hermetically sealed receptacles (39), each receptacle containing a single dose of a pressurized formulation comprising a pharmaceutically active ingredient and a liquefied aerosol propellant consisting of HFA 134a, HFA 227 or a mixture thereof and wherein at least a portion (39a) of each receptacle is perforable.

Abstract: A medicament dispenser for use with at least one medicament carrier carrying multiple distinct medicament portions, said medicament dispenser comprising (a) a dispensing mechanism actuable for dispensing the distinct medicament portions carried by the at least one medicament carrier; (b) a mouthpiece; and (c) a cover for the mouthpiece, the cover being movably mounted to the dispenser for sequential movement from a first position, in which the mouthpiece is covered, to a second position, in which the mouthpiece is at least part-uncovered, to a third position in which the mouthpiece is uncovered; wherein the cover is adapted to couple with the dispensing mechanism such that movement of the cover from the second position to the third position, but not the first position to the second position, results in actuation of the dispensing mechanism.

Abstract: An inhaler comprising a tubular body (1) defining a tubular air flow passage with a bendable section, preferably a U-shaped section comprising peripherally extending corrugations and means for supplying a dose of at least one active inhalable, particulate substance into the flow passage and a cap (2). According to the invention the dose of the at least one active, inhalable particulate substance is placed in the cap (2) to be released from said cap substantially at the beginning of the corrugations in the intake direction.

Abstract: A drug transfer system is adapted to transfer a powdered drug into a patient via inhalation. The drug transfer system includes a drug container or packet that removably inserts into an inhaler device. As the patient inhales from the inhaler device, the drug flows from the container, through the inhaler device, and into the patient's respiratory system. The system is adapted for ease of use without requiring the user to perform any cumbersome manipulations of the drug packet during insertion into the inhaler or during inhalation of the drug.

Abstract: A pack containing medicament, the pack including a base having first and second opposing faces, at least one recess being formed in the first face, a foil secured to the first face so as to form with the at least one recess a sealed compartment for housing medicament and a substantially rigid member housed in the compartment extending generally from the second face to the first face such that the member can be pushed from the second face so as to rupture the foil outwardly of the compartment at the first face without compressing the medicament and a dispensing device for use with or including such a pack having an actuator for pushing the member from the second face so as to rupture the foil outwardly of the compartment at the first place.

Abstract: An inhalation device is described for use with a medicament pack in which at least one container for medicament in powder form is defined between two sheets peelably secured to one another. The device comprises means for peeling the sheets apart at an opening station to open the container; and an outlet, communicating with the opened container, through which a user can inhale medicament in powder form from the opened container.

Abstract: An arrangement for opening a cavity sealed by a sealing sheet the cavity housing a medicament, the arrangement comprising a separating element bondable to the outer surface of the sealing sheet above said cavity, and guiding means for guiding said separating element away from said cavity, whereby the sealing sheet lid covering said cavity and bonded to said separating element is completely separated from the rest of the sealing sheet and removed, and the cavity is opened. A pack for doses of medicament, comprising at least one cavity for housing a dose of medicament, the cavity being sealed by a sealing sheet, where the outer surface of the sealing sheet above the cavity is bonded to the above-mentioned separating element. A dispensing device for dispensing doses of medicament, comprising a dispenser outlet, the dispensing device comprising said arrangement for opening a cavity sealed by a sealing sheet.

Abstract: Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.

Abstract: An inhaler device for inhalation of a medicament from a pierceable capsule comprises a housing for receiving a medicament capsule; closure means for closing the housing, said closure means being moveable relative to the housing; piercing means suitable for piercing a medicament capsule; wherein movement of the closure means relative to the housing causes movement of the piercing means. The invention also provides a holder for a medicament capsule which holder comprises a chamber suitable for receiving a medicament capsule; and means for generating turbulence in a fluid flow through the chamber such that, in use, the turbulent fluid flow causes vibration of a capsule received by the chamber so as to assist in releasing medicament contained within the capsule.

Abstract: In a device to deliver a powdery medicine into a nasal cavity, one-way valve 33 is built in an air flow passage 31 of a capsule housing/holding part 30, the one-way valve 33 is controlled for the opening pressure by a spring 34 and opens by a pressure of air from the pump 50, the one-way valve end 71 does not interfere the setting/detaching operation of the capsule setting/detaching part 40 and the capsule K when the one-way valve 33 is opened and intrudes as far as the inside of the capsule to disperse the medicine in the capsule K when the one-way valve 33 is opened by pressing of the pump 50 upon dosing thereby capable of reliably dosing at a adequate dose also including the medicine falling as far as the one-way valve 33 to the nasal cavity of the user.

Abstract: A nebule comprising at least one identification marker or label can be coupled an aerosol generator. The identification marker can be sensed by a sensing device on the aerosol generator so as to identify the liquid in the nebule to the controller of the aerosol generator. The controller of the aerosol generator can control the aerosol generator based on the information read from the identification marker.