Abstract: An inhaler is disclosed. It comprises a housing to receive a strip having a surface and a plurality of blister pockets depending from said surface. Each blister pocket contains a dose of medicament for inhalation by a user. The inhaler has a blister strip drive mechanism including a blister strip drive member shaped to contact the strip along a line defined by the crease between a blister pocket and said surface, to drive said strip.

Abstract: A passive inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler has a flow resistance of at least 75000 Pa1/2s/m3.

Abstract: An inhaler (1) for delivery of a powder-form inhalation formulation from a blister strip (2) with a plurality of blister pockets (3) is proposed. A tape is used for numbering.

Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.

Abstract: An inhaler is disclosed. It comprises a housing to receive a strip having a plurality of blisters, each blister having a breachable lid and containing a dose of medicament for inhalation by a user, an indexing wheel mounted in the housing rotatable to drive a strip to sequentially move blisters into alignment with a blister piercing member, a control element pivotally mounted to the housing and a drive mechanism configured to couple the control element to the indexing wheel during part of the rotation of the control element by a user so that the indexing wheel rotates together with the control element.

Abstract: A fluid dispenser device including at least one individual reservoir (21) containing a single dose of fluid, such as powder, opening means (40) being provided for opening an individual reservoir (21) each time the device is actuated, the device including a dispenser chamber (70) for receiving the dose of fluid contained in a reservoir (21) after said reservoir has been opened, an inhalation endpiece (15), and an inhalation trigger system that comprises a deformable air-chamber (61) that co-operates with said dispenser chamber (70), said dispenser chamber being displaceable between a rest position and an inhalation position, such that during inhalation through said inhalation endpiece (15), said air chamber (61) is deformed, thereby displacing said dispenser chamber from said rest position to said inhalation position.

Abstract: A nasal comfort device provides humidified air to the nasal passages of a user. The device, which is attachable to a user's face, may include an evaporative surface and a reservoir that is fluidically connected to the evaporative surface. The reservoir may be positioned remotely from the evaporative surface and connected to the evaporative surface with a conduit. A support structure may include one or more support arms which maintain the evaporative surface below the nose. In some embodiments, the device may filter air instead of, or in addition to, humidifying the air. Medications or other agents may be included in the liquid being evaporated or on the evaporative surface.

Abstract: An inhaler for administering a medicament in the form of inhalable substances, formulations or mixtures of substances comprises a housing (1) having an inner cavity for holding the medicament, which is coupled to a mouthpiece (2). The housing (1) is rigidly connected to the mouthpiece (2).

Abstract: Dispersible powder compositions suitable for inhalation are disclosed, the compositions including a human interleukin mutein (mhIL-4).

Abstract: An inhaler which comprises a base having a plurality of consecutive sealed cavities containing medicament. Foil portions are on one side attached to the base for sealing the medicament within respective associated cavities. A plurality of separating elements are attached to the other side of the foil portions, each separating element being associated with a respective cavity for separating a foil portion from that cavity. Each separating element can be moved-away from its associated cavity so that the sealing foil portion is separated from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow, and then returned with the attached foil portion to cover its associated cavity. A method of operating an inhaler is also disclosed.

Abstract: A fluid dispenser device including a body (10) that is provided with a dispenser opening (1) and at least one cover element (11; 12) that is displaceable between a closed position, in which it covers said dispenser orifice (1), and an open position, in which it uncovers said dispenser orifice (1), said device further including: an elongate flexible strip (20) supporting a plurality of reservoirs (21) each containing a dose of fluid or powder; reservoir-opening means (30) for opening a respective reservoir on each actuation; and displacement means (40) for displacing said flexible strip (20) before and/or during and/or after each actuation, so as to bring a full reservoir into register with said reservoir-opening means, the leading end (1) of said flexible strip (25), in the displacement direction of said strip, being fastened to a receiver element (20) that is rotatably mounted relative to said body (50), said receiver element (50) being adapted to exert a traction force on said elongate strip (20).

Abstract: In an inhaler for administering a powdery medicament in the form of an inhalable substance, substance formulation or mixture, a blister cavity to be opened by piercing elements (11) is mounted in the lower part (1) of a housing (2), which is composed of an upper part (6), designed as mouthpiece and with an inhalation channel (16), and of the lower part (1), which comprises an air inlet opening (9). The inhalation channel (16) of the upper part (6) of the housing has a unit (15) for dispersing the powdery medicament, said unit (15) being connected to the piercing elements (11), wherein the upper part (6) of the housing can be moved relative to the lower part (1) of the housing in order to open the blister cavity.

Abstract: A fluid dispenser device comprising: a body (10); at least one individual reservoir (21); movable support means (50) that receive at least one reservoir (21), and that are displaceable between a non-dispensing position and a dispensing position; reservoir-opening means (80) for opening a reservoir when said opening means are actuated; loading means (800) for urging said movable support means towards said dispensing position; blocking means (100) for retaining said movable support means in the non-dispensing position; and inhalation trigger means (60); said blocking means (100) comprising a blocking element (110) that is movable between a blocking position and an unblocking position, said blocking element (110) co-operating with a projection (501) that is secured to movable support means (50).

Abstract: An inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler comprises a mouthpiece cover pivotable to move the blister strip onward.

Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.

Abstract: A powder inhaler for administering powder by inhalation, comprising: a flow path defined by a plurality of surfaces through which a stream of air is in use drawn on inhalation by a user; and dosing means (18) for providing a dose of powder to the flow path for entrainment in the stream of air; characterized in that the inhaler further comprises dislodging means for dislodging powder accumulated on a surface of the flow path downstream of the dosing means (18).

Abstract: The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein a plurality of individual blister packs are arranged in a rotary cassette that fits within a housing, and wherein the individual blister packs are dragged up into a clamping position between the vibration element and a piercing element. The motion of the blister pack is controlled by a rotary disk within the housing which further coordinates the movement of the piercing and vibrating elements for the piercing and deaggregation, respectively, of the individual blister packs.

Abstract: A conventional respiratory nebulizer has an emergency medication dose storage system conveniently useable in an emergency to deliver the stored medication dose directly to the nebulizing chamber quickly, reliably, and with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication.

Abstract: A fluid dispenser device including a body (10) that is provided with a dispenser orifice (1), said body (10) containing a plurality of reservoirs (21) formed on a common substrate formed by an elongate strip (20) that includes a leading end (25) and a trailing end (28), the device further including reservoir-opening means (30) that are adapted to open a respective reservoir each time the device is actuated, and drive means (40) for driving the elongate strip (20), so as to bring a full reservoir into register with said opening means before and/or during and/or after each actuation of the device, the device including at least one movable wall (500; 600, 601) that separates, at least in part, a storage housing (11) for storing the elongate strip (20) from a reception housing (15) for receiving the elongate strip (20), said elongate strip (20) being disposed, in particular rolled up in a roll, mainly in said storage housing (11) before the device is used for the first time, and being displaced progressively in s

Abstract: A medication inhaler having an inhaler body with a medication container chamber for receiving a medication container and at least one air passage connecting the medication container chamber with external air and a mouthpiece axially engageable with the inhaler body and having a mouthpiece chamber for communication with a patient's respiratory system and a hollow medication delivery needle communicating with the mouthpiece chamber. The medication delivery needle extends toward the medication container chamber and has at least one opening for passing exterior air and medication from an interior space of a medication container in the medication container chamber through the needle and to mouthpiece chamber.

Abstract: A fluid dispenser device comprising a body (10) provided with a dispenser orifice (15), said device further comprising: an elongate flexible strip (20) supporting a plurality of reservoirs (21) each containing a dose of fluid; reservoir-opening means (80) for opening a respective reservoir on each actuation; first displacement means (30) for causing said flexible strip (20) to advance before and/or during and/or after each actuation, so as to bring a full reservoir into register with said reservoir-opening means; and second displacement means (50) for displacing a full reservoir (21) against said opening means (80) each time the device is actuated, said device including positioning means (300) that are adapted to position the full reservoir accurately relative to the reservoir-opening means (80) when it is displaced thereagainst, so as to guarantee that opening is predetermined and reproducible on each actuation.

Abstract: A method for forming at least one opening in a receptacle comprises the steps of providing a receptacle having a cover with an exterior surface and an interior surface covering a cavity. A cutting mechanism is also provided having at least one blade. The cover is pierced with the blade, and the blade is moved through the cover to cut a portion of the cover and create an opening in the cover to provide access into the cavity. Further, the cut portion curls on top of the exterior surface as the opening is created.

Abstract: A conventional respiratory nebulizer has an emergency medication dose storage system delivering the stored medication dose directly to the nebulizing chamber with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication. The delivery system includes a slicing blade to sever the capsule and a looped paddle follower to move the severed portion out of the way of fluid flow.

Abstract: A fluid dispenser device comprising a body (10) provided with a dispenser orifice (15), said device further comprising: an elongate flexible strip (20) supporting a plurality of reservoirs (21) each containing a dose of fluid; reservoir-opening means (80) for opening a respective reservoir on each actuation; first displacement means (30) that can be actuated so as to cause said flexible strip (20) to advance before and/or during and/or after each actuation, so as to bring a full reservoir into register with said reservoir-opening means; and second displacement means (50) for displacing a full reservoir (21) against said opening means (80) each time the device is actuated, the leading end (25) of said flexible strip (20), in the advance direction of said strip, being fastened to a receiver element (500) that is rotatably mounted, said receiver element (500) being adapted to exert a traction force on said elongate strip (20), said device including an abutment element (5000) that is disposed between said first d

Abstract: A fluid dispenser device comprising: a body (10) provided with a dispenser orifice (15); dispenser means (50, 80) for dispensing a dose of fluid on each actuation; and a dose counter for indicating the number of doses that have been dispensed or that remain to be dispensed, said counter comprising: a first rotary counter element (127) provided with a first surface including first indicator means (125), such as digits, and provided with at least one first set of teeth (128, 129); a second rotary counter element (227) provided with a second surface including second indicator means (225), such as digits, and provided with at least one second set of teeth (228, 229); and a movable actuator element (160) that is displaceable between a first position and a second position, said actuator element including a projection (168) that is adapted to co-operate with said first set of teeth (128) of said first counter element (127), so as to cause said first counter element (127) to turn while said actuator element (160) is

Abstract: An Inhaler for delivering an aerosolized dose of a powdered drug for inhalation by a user is disclosed. The inhaler comprises a drug entrainment device vice to a receive a package having a piercable lid containing a dose to be delivered, the device including a drug outlet tube terminating with a primary piercing element to pierce an opening in said lid when a package is located in the inhaler, a secondary piercing member to pierce a plurality of peripheral openings in said lid and, an airflow path to enable the supply of a charge of gas into the package via said peripheral openings to scour the interior of a pierced package such that all or substantially all of the dose is entrained in the gas and flows out of the package via the drug outlet tube. A medicament pack is also disclosed.

Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.

Abstract: An inhaler for delivering a powdered inhalable formulation from a blister strip having a plurality of blister pouches. The inhaler has a receiving chamber for the used blister strip separated from a reservoir for the unused blister strip.

Abstract: A peroral powder delivery device having a capsule holder for loading the capsule into a body is attached so as to be capable of advancing into and retracting from the inside of the body, the body has a cutter blade to make holes on both ends of the capsule as it advances into the body being held by the capsule holder, first and second air passageways having connection ports in communication with the holes in the capsule loaded in the body, the first air passageway has an inhaling port for inhaling the peroral powder in the capsule and the second air passageway has a suction valve that opens by the inhaling force from an inhaling port introduce air into the capsule.

Abstract: A drug transfer system is adapted to transfer a powdered drug into a patient via inhalation. The drug transfer system includes a drug container or packet that removably inserts into an inhaler device. As the patient inhales from the inhaler device, the drug flows from the container, through the inhaler device, and into the patient's respiratory system. The system is adapted for ease of use without requiring the user to perform any cumbersome manipulations of the drug packet during insertion into the inhaler or during inhalation of the drug.

Abstract: For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere. The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmaceutically active substance. The liquid in the cartridge is protected from external influences. The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.

Abstract: An inhaler (1) for delivery of a powder-form inhalation formulation from a blister strip (2) with a plurality of blister pockets (13) is proposed. The used part of the blister strip (12) is wound up and/or kept taut and/or free of loops by means of a spring (15).

Abstract: A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation includes: an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; and a cannula guide extending from the upper end of the displacing device to the cartridge chamber, wherein insertion of a cannula through the guide pierces the sealed opening and releases the pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.

Abstract: A delivery device, in particular a breath-actuated nasal delivery device, for delivering substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.

Abstract: A fluid dispenser device including at least one individual reservoir (21) containing a single dose of fluid, opening means (40) being provided for opening an individual reservoir (21) each time the device is actuated, said opening means (40) comprising perforator and/or cutter means (41) and movable support means (50), said movable support means (50) being adapted to displace an individual reservoir (21) against said perforator and/or cutter means (41) on each actuation.

Abstract: A dry powder inhaler consisting of first chamber having an orifice for holding a dry powder and a gas, and a second chamber for receiving a deaggregated form of the dry powder and for communicating the deaggregated dry powder to a user. A synthetic jet drives the dry powder from the first chamber to the second chamber.

Abstract: There is provided a medicament dispenser for use with a medicament carrier having a plurality of pockets for containing medicament wherein said pockets are spaced along the length of and defined between two peelable sheets secured to each other, said dispenser having an internal mechanism for accessing said medicament contained within said medicament carrier. The internal mechanism comprises a carrier drive means; indexing means and clutch means, in communication therebetween. The clutch means comprises a gearing surface defining plural gear engagement positions; and plural gear teeth for engaging said plural gear engagement positions. The plural gear teeth are arranged such that at any one time only a single gear tooth engages a single gear engagement position.

Abstract: An inhalation device comprising a base having a slot for insertion of a single blister containing a dose of medicament to be inhaled into the base is disclosed. The inhaler has a mouthpiece pivotally mounted to the base which carries a blister piercing element operable to pierce a blister received in said slot when the mouthpiece is pivoted relative to the base. When a user inhales on the mouthpiece, the dose is entrained in an airflow and flows out of the blister through the mouthpiece and into the user's airway.

Abstract: A device for the controlled inhalation of therapeutic aerosols comprises means providing individual patient parameters and/or aerosol parameters for the inhalation. The aerosol doses, such as the tidal volume and the respiratory flow, are individually adjusted on the basis of these individual parameters. Thus, the inhalation device may be individually adjusted to the patient to be treated.

Abstract: A delivery device that includes a cutter for opening a barrier layer to provide fluid access to a dose chamber, and a diverting structure for direct air flow toward the dose chamber.

Abstract: A fluid dispenser device comprising a body (10), said device further including: an elongate flexible strip (20) supporting a plurality of reservoirs (21) each containing a dose of fluid or powder; reservoir-opening means (30) for opening a respective reservoir on each actuation; first displacement means (40) for causing said flexible strip (20) to advance before and/or during and/or after each actuation, so as to bring a full reservoir into register with said reservoir-opening means; and second displacement means (45) for displacing a full reservoir (21) against said opening means (30) each time the device is actuated, the leading end (25) of said flexible strip (20), in the advance direction of said strip, being fastened to a receiver element (50) that is rotatably mounted relative to said body (10), said receiver element (50) being adapted to exert a traction force on said elongate strip (20), said traction force being independent of said first displacement means (40), said traction force being applied on s

Abstract: A body section 2 is formed with a capsule insertion hole 6. A movable section 3 includes a capsule puncture needle 9 arranged to be moved into or out of the capsule insertion hole 6. The body section 2 and the movable section 3 are connected to be relatively pivoted at least between a posture in which the capsule insertion hole 6 is exposed, and a posture in which the capsule insertion hole 6 is hid by the body section 2. The body section 2 (a side wall 6e of a protrusion 6a) is arranged to restrict the advancing movement of the capsule puncture needle 9 in the state in which the body section 2 and the movable section 3 are in the posture in which the capsule insertion hole 6 is exposed.

Abstract: A nebulized fluid, generated by vibrating an aerosolization element, is introduced into a breathing circuit during a certain interval of a patient's breathing cycle. In some embodiments, the fluid comprises an antibiotic that is selected to treat a pulmonary infection resulting from mechanical ventilation.

Abstract: The present invention provides an inhaler, which separates the drug aerosolization process and the drug delivery process within the inhaler, and controls the inhalation air flow profile in a way, such that transportation of the drug in the inhaler flow channel is enveloped in a laminar air stream presented to the air tract of the user, thereby eliminating drug deposition on the inhaler inside walls. The inhaler invention therefore provides advantages over other inhalers, especially, when a repeatable emitted dose is important and generally, where contamination and hygiene in the flow channel is an issue as is the case with multi-dose inhalers.

Abstract: An assembly of a tube-shaped body and a tube-shaped cap, which are open at one distal side, is provided to manufacture a capsule for enclosing a medicine. At least one recess is arranged in an outer surface of the body, wherein at least one fixating bulge is arranged in an inner surface of the cap, which is destined to be snugly received in the recess in the outer surface of the body in order to realize a fixed snap connection between the body and the cap. A smallest inner diameter of the fixating bulge of the cap is equal to or smaller than a smallest outer diameter of the recess in the body, which contributes to realizing a fixed snap connection which is firm to such an extent that the capsule is suitable for application in an inhalation apparatus comprising provisions for piercing the capsule at least one place.

Abstract: Apparatus and method for respiratory drug delivery using cartridge containing drug and propellant. User inserts cartridge into body of apparatus and activates a mechanism for opening drug compartment and propellant compartment, resulting in mixing and de-agglomeration of drug for respiratory delivery.

Abstract: A device that delivers a powdery medicine for a nasal cavity includes positioning guides that cause a capsule to slide as far as a predetermined position and are provided on the side of cutters to make holes on both ends of the capsule provided between the connection port on the side of a nozzle that sprays the powdery medicine into the nasal cavity. The device further includes a connection port on the side of a pump that supplies spray air to the nozzle in order to make the size of the holes made on both ends of the capsule constant, wherein a distance between the connection ports is made shorter than a distance between blade tips of the cutters.

Abstract: Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.

Abstract: A medication inhaler comprising an inhaler body, having a medication container chamber for receiving a medication container and an air passage coupling the medication container chamber with exterior air, and a mouthpiece axially engageable with the inhaler body. The mouthpiece has a mouthpiece chamber and a medication delivery needle communicating with the mouthpiece chamber. The needle extends toward the medication container chamber and has an opening for supplying exterior air and medication from an interior cavity of the medication container, accommodated within the medication container chamber, through the needle and to mouthpiece chamber.

Abstract: An inhalation device for transpulmonary administration comprises: a chamber (16) for containing a pharmaceutical composition which is pulverized into fine particles by an air-generated impact for dispersal in air; an air inlet flow path (2) for introducing to the chamber (16) outside air to apply the air-generated impact to the pharmaceutical composition and for injecting the outside air toward the pharmaceutical composition; an inhalation flow path (1) for inhaling the pulverized pharmaceutical composition; a housing (9) for accommodating the chamber (16), the air inlet flow path (2), and the inhalation flow path (1); a mouthpiece (10) provided at one end of the housing (9), the mouthpiece (9) being provided with a mouth-side flow path (11) which communicates with the inhalation flow path (1), and an auxiliary flow path (12).