Utilizing Diverse Fluids Patents (Class 137/806)
  • Patent number: 9630158
    Abstract: The present invention relates to systems and methods of performing in-line mixing of assay components and delivery of such mixed components into microfluidic channels. In one aspect, a method of delivering mixed assay components is provided which comprises causing an unmixed primer solution to flow into a first mixing channel, the unmixed primer solution comprising a common reagent and a primer, holding the unmixed primer solution in the first mixing channel for at least a threshold amount of time to allow the unmixed primer solution to transition into a mixed primer solution, causing a buffer to flow into a second mixing channel, the buffer comprising the common reagent but not including a primer, and, after holding the unmixed primer solution in the first mixing channel for at least the threshold amount of time, drawing, from the first mixing channel, the mixed primer solution into a common exit channel.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: April 25, 2017
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventor: Hiroshi Inoue
  • Publication number: 20150107709
    Abstract: A microdevice structure of microchannel chip is provided which includes one gas channel and at least one liquid channel. The microchannel connects the gas channel and each liquid channel. The most basic microdevice of the mirochannel chip comprises micropressure sensor, microvalve, micropiston and micropump which are controlled by digital pressure gas microcircuit in the chip. Each microdevice isolates the gas phase and liquid phase by microhole without any movable component and any special ventilate or elastic material. The gas-liquid interface is driven by the pressure difference of gas phase and liquid phase to enable the microdevice to implement the functions, such as sensing pressure, switching fluid channel, transporting liquid effectively, and so on.
    Type: Application
    Filed: September 14, 2010
    Publication date: April 23, 2015
    Inventor: Xingyue Peng
  • Patent number: 8926816
    Abstract: Systems and methods for trapping and moving individual particles of a target material of a suspension are disclosed. In one aspect, a system includes a tube and an electronically addressable float. The float includes one or more arrays of electrodes in which each electrode can be independently addressed to create non-uniform electric fields that trap and isolate target particles near the float. The electrodes can be dynamically operated to move the target particles to particular locations on the float for analysis and collection.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: January 6, 2015
    Assignee: Rarecyte, Inc.
    Inventor: Joshua John Nordberg
  • Publication number: 20140360587
    Abstract: A device for reducing friction of a viscous fluid flow in a conduit includes a body (10,110) positionable to define at least a segment of a flow path for the viscous fluid in or contiguous with the conduit, a cavity (40,140) in the body for retaining lubricating fluid, and at least one port (42,142) in the body for delivering lubricating fluid to the cavity. A fluid outlet arrangement (48,148) from the cavity delivers lubricating fluid to the flow path to form a downstream lubricating film about viscous fluid flowing therein. The fluid outlet arrangement comprises a substantially continuous opening or ring of close spaced openings about the flow path. The cavity comprises an array of passages in the body that includes a plurality of elongate passages (55,155) that extend about the flow path effective collectively to reduce the pressure variation and therefore velocity variation of the delivered lubricating fluid along the outlet arrangement. A corresponding method is also disclosed.
    Type: Application
    Filed: February 7, 2013
    Publication date: December 11, 2014
    Inventors: Jie Wu, Lachlan Graham, Gregory Mark Short, Dean William Harris
  • Patent number: 8820357
    Abstract: A method for implementing a logic operation employs an all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices that are constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: September 2, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Manu Prakash, Neil Gershenfeld
  • Patent number: 8776830
    Abstract: An invention for transporting material is described. The material, which may be or include a liquid or particles, be transported floats on and flows on a more dense fluid. Standing waves may be induced in the more dense fluid, and devices are provided to either force the transported fluid in a direction, or to prevent the transported fluid from flowing in a direction counter to the flow direction. The inventive apparatus and method have the ability to transport fluids long distances with much less frictional losses than convention technology.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: July 15, 2014
    Inventors: Walter Chen, C. K. Hari Dharan
  • Patent number: 8763623
    Abstract: Systems and methods related to handling solids in microfluidic systems are generally described. Many of the systems and methods described herein address the need to inhibit the formation of blockages in microfluidic channels.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: July 1, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Ryan L. Hartman, John R. Naber, Nikolay Zaborenko, Jonathan P. McMullen, Klavs F. Jensen
  • Patent number: 8657017
    Abstract: Apparatus and methods for controlling the flow of fluid, such as formation fluid, through an oilfield tubular positioned in a wellbore extending through a subterranean formation. Fluid flow is autonomously controlled in response to change in a fluid flow characteristic, such as density or viscosity. In one embodiment, a fluid diverter is movable between an open and closed position in response to fluid density change and operable to restrict fluid flow through a valve assembly inlet. The diverter can be pivotable, rotatable or otherwise movable in response to the fluid density change. In one embodiment, the diverter is operable to control a fluid flow ratio through two valve inlets. The fluid flow ratio is used to operate a valve member to restrict fluid flow through the valve.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: February 25, 2014
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Jason D Dykstra, Michael Linley Fripp, Orlando DeJesus, John C. Gano, Luke Holderman
  • Publication number: 20140014212
    Abstract: A carrier-gas mixture is directed through a fluid flow path in a combined heat and mass transfer device, which can be operated at sub-atmospheric pressure. Heat and mass are transferred from or to the carrier-gas mixture via interaction with a liquid composition that includes a vaporizable component in a liquid state to substantially change the content of the vaporizable component in the carrier-gas mixture via evaporation or condensation. The mass flow rate of the carrier-gas mixture is varied by extracting or injecting the carrier-gas mixture from at least one intermediate location in the fluid flow path, and/or the mass flow rate of the liquid composition is varied by extracting or injecting the liquid composition from at least one intermediate location in the fluid flow path; and the flow of the carrier-gas mixture or the liquid composition is regulated to reduce the average local enthalpy pinch in the device.
    Type: Application
    Filed: June 24, 2013
    Publication date: January 16, 2014
    Applicants: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Prakash Narayan Govindan, Gregory P. Thiel, Ronan K. McGovern, John H. Lienhard, Sarit K. Das, Karim M. Chehayeb, Syed M. Zubair, Mohammed A. Antar
  • Patent number: 8540416
    Abstract: The present invention provides a device for handling fluids, and more particularly a merging apparatus for fluidic and microfluidic devices utilizing passive valving in conjunction with a single sensor to uniformly blend contributory working fluid streams. Symmetric and non symmetric embodiments with and without branch channels are described. The present invention also provides methods for merging liquids using the device of the invention.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: September 24, 2013
    Assignees: Capitalbio Corporation, Tsinghua University
    Inventors: Xiaosheng Guan, Min Guo, Cheng Zhou, Yuming Hu, Jing Cheng
  • Patent number: 8528582
    Abstract: The application of an optical beam redirects sheathed micro-fluidic flow without direct interaction with the sample. The hydrodynamic properties of the sheath are locally modified due to optical absorption and heating, resulting in a spatial shift of the sample flow. The technique can result in up to 100 ?m shift at peak flow velocities of 19 mm/sec.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: September 10, 2013
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Janet W. Lou, Carl A. Villarruel, Ross Schermer
  • Publication number: 20130167939
    Abstract: A method and system for reducing the visibility of a plume created at the outlet of an industrial process, where the industrial process expels hot, humid air into the outside air through an output area of an outlet and, as a result of the expelled air A coming into contact with the outside air E, a visible plume might otherwise be created. The method includes the steps of having an auxiliary air that is dryer than the process air and hotter than the outside air available and combining this auxiliary air with the hot, humid process air such that the auxiliary air forms a protective, insulating or sheathing layer of air around the process air. This combination of the process air with the auxiliary are is carried out after (i.e., downstream from) an extraction process or processes of the industrial process and in the atmosphere generally adjacent to the output area of the process outlet.
    Type: Application
    Filed: December 26, 2012
    Publication date: July 4, 2013
    Applicant: BRUNNSCHWEILER S.A.
    Inventor: Brunnschweiler S.A.
  • Patent number: 8476382
    Abstract: This present invention provides devices for the parallelization of the formation of droplets in a multiple droplet generator integrating two or more parallel flow-focusing devices (FFDs) with either identical, or different, geometries. In the parallel identical FFDs, emulsification generates droplets with a narrow (below 4%) polydispersity despite weak coupling between the identical flow-focusing devices. Formation of droplets in the integrated droplet generator comprising FFDs with different dimensions of the microchannels occurs with strong coupling between the FFDs and produces droplets with varying sizes and size distributions. For such devices the regime in which emulsification produces droplets with varying dimensions and a narrow size distribution have been identified. The results of this work can be used in scaling up the production of droplets and in the simultaneous production of droplets and particles with different dimensions.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: July 2, 2013
    Inventor: Eugenia Kumacheva
  • Patent number: 8398938
    Abstract: A microfluidic thermal bend actuated pressure pulse valve having an inlet for receiving a flow of liquid, an outlet for outputting the flow of liquid, a meniscus anchor between the inlet and the outlet such that the flow from the inlet towards the outlet stops at the meniscus anchor where the liquid forms a meniscus, a movable member for contacting the liquid, and, a thermal expansion actuator for displacing the movable member to generate a pulse in the liquid to dislodge the meniscus such that the liquid flow towards the outlet resumes.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: March 19, 2013
    Assignee: Geneasys Pty Ltd
    Inventors: Mehdi Azimi, Matthew Taylor Worsman, Kia Silverbrook
  • Patent number: 8342207
    Abstract: The invention relates to a microfluidic device for making a liquid/liquid or gas biphasic system using a first liquid or a gas and a second liquid, non-miscible with each other, the device having a first hydrophobic surface for the second liquid, the first liquid forming a layer (6) on said first hydrophobic surface. The device comprises means for introducing a drop (7) of the second liquid into the layer of first liquid or gas and in contact with said first hydrophobic surface, and means for displacing the drop on said first hydrophobic surface along a determined path, the device having on the path of the drop, at least one wetting defect causing, upon passing of the drop over this defect, failure of the triple line of contact of the drop on the first hydrophobic surface and inclusion of first liquid (8) or gas into the drop. The invention also relates to the associated method.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: January 1, 2013
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Olivier Raccurt, Yves Fouillet
  • Publication number: 20120285548
    Abstract: A conduit system comprising: a conduit formed by a surface extending from a first end to a second end, wherein the conduit is configured to channel a mixture stream from the first end to the second end; and a plurality of fluid delivery features disposed along the conduit between the first end and the second end, wherein each fluid delivery feature is configured to deliver a conditioning fluid into the conduit in an annular formation in a direction angled towards the second end in the same direction as the flow of the mixture stream, thereby providing a sheath of conditioning fluid between the conduit surface and the mixture stream.
    Type: Application
    Filed: November 8, 2011
    Publication date: November 15, 2012
    Applicant: SDCmaterials, Inc.
    Inventors: Frederick P. Layman, Maximilian A. Biberger
  • Patent number: 8235071
    Abstract: A method for implementing a logic operation employs an all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices that are constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: August 7, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Manu Prakash, Neil Gershenfeld
  • Publication number: 20120189967
    Abstract: A gas burner apparatus for discharging a mixture of fuel gas, air and flue gas into a furnace space of a furnace wherein the mixture is burned and flue gas having a low content of nitrous oxides and carbon monoxide is formed is provided. The burner tile includes at least one gas circulation port extending though the wall of the tile. The interior surface of the wall of the tile includes a Coanda surface. Fuel gas and/or flue gas conducted through the gas circulation port follows the path of the Coanda surface which allows more flue gas to be introduced into the stream. The exterior surface of the wall of the tile also includes a Coanda surface for facilitating the creation of a staged combustion zone. Also provided are improved burner tiles, improved gas tips and methods of burning a mixture of air, fuel gas and flue gas in a furnace space.
    Type: Application
    Filed: March 28, 2012
    Publication date: July 26, 2012
    Applicant: John Zink Company, LLC
    Inventors: Roger L. Poe, James Wilkins, Michael G. Claxton
  • Patent number: 8210209
    Abstract: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: July 3, 2012
    Assignee: Cytonome/ST, LLC
    Inventors: John R. Gilbert, Sebastian Böhm, Manish Deshpande
  • Patent number: 8206975
    Abstract: A method and a microfluidic device are provided to regulate fluid flow by equalization of channel pressures. The fluid flow is regulated by way of valve-actuated channel pressures.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: June 26, 2012
    Assignee: California Institute of Technology
    Inventors: Xiaoyan Robert Bao, Stephen R. Quake, Melvin I. Simon
  • Patent number: 8206994
    Abstract: The invention relates to a method for treating drops in a microfluid circuit, comprising at least one microchannel (12) through which the drops flow, characterized in that a laser (26) is brought to bear on the interface of said drops in the transport liquid (F3), or on the interface of drops in contact, in order to carry out a sorting of the drops, to form nanodrops from a larger drop or to fuse drops (60, 64) in contact and initiate reactions between the fluids contained in said drops.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: June 26, 2012
    Assignees: Centre National de la Recherche Scientifique, Ecole Polytechnique
    Inventors: Charles N Baroud, Jean-Pierre Delville
  • Publication number: 20120152361
    Abstract: A device and method are provided for pumping fluid through a channel of a microfluidic device. The channel has an input and an output. The channel is filled with fluid and droplets under pressure are sequentially directed at the input of the channel so as to cause fluid to flow in the channel towards the output.
    Type: Application
    Filed: December 20, 2010
    Publication date: June 21, 2012
    Inventors: Justin C. Williams, David J. Beebe, Pedro Resto, Erwin Berthler
  • Publication number: 20120111436
    Abstract: By storing a liquid to be treated in a treatment tank main body 10 having a bottom portion 10g that narrows downward, with particles of materials to be treated dispersed therein, taking out the liquid to be treated from a position lower than the liquid level of the treatment tank main body 10, and returning the liquid to the bottom portion 10g of the treatment tank main body 10, thereby circulating the liquid to be treated while forming a vortex flow within the treatment tank main body 10, and at the same time supplying air bubbles from the lower part of the treatment main unit 10, a first component contained in froths is separated from a second component, which is less susceptible to floatation, contained in the liquid to be treated.
    Type: Application
    Filed: July 15, 2010
    Publication date: May 10, 2012
    Applicants: Kitakyushu Foundation for the Advancement of Industry, Science and Technology, JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Yasunori Matsufuji, Koji Takasu, Kiyotaka Tatsumi
  • Patent number: 8171956
    Abstract: There is provided a liquid supply method in which, when preparing a solution that can be used as washing water and the like by supplying a minute amount of chemicals and the like to ultrapure water, the amount of supply solution that is supplied can be accurately determined. In this liquid supply method, a solution is prepared by supplying a supply liquid to a primary fluid that is circulating in a primary fluid circulation tube (2). This liquid supply method uses a liquid supply apparatus (1) that includes: a supply section (3) that delivers the supply liquid; and a supply liquid circulation tube (4) that causes the supply liquid to flow from the supply section (3) to the primary fluid circulation tube (2), the internal diameter of the supply liquid circulation tube (4) being between 0.01 and 1 mm.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: May 8, 2012
    Assignees: Dainippon Ink and Chemicals, Inc., KITZ SCT Corporation
    Inventors: Toshikazu Suganuma, Yasushi Tomita, Kazunari Sakai, Naoki Hada, Katsuhiko Kazama
  • Patent number: 8136553
    Abstract: A microfluidic circuit comprising microchannels (24, 26) containing different fluids (F1, F2), with a laser beam being focused at (32) on an interface (30) between the fluids so as to form a pump, a valve, or a mixer, for example.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: March 20, 2012
    Assignees: Centre National de la Recherche Scientifique, Ecole Polytechnique
    Inventors: Charles Baroud, Jean-Pierre Delville, Régis Wunenburger, Patrick Huerre
  • Patent number: 8104513
    Abstract: Disclosed is a gas flow path switching unit including a gas passage section with a target gas passage for allowing said target gas to pass therethrough. The target gas passage includes a main passage having a proximal end serving as said gas inlet and a number n of branch passages each provided with a respective gas outlet at a terminal end thereof. The branch passages are formed by repeating two or more times a branching process of branching said main passage into two sub passages at a branch point at a distal end of said main passage and further branching at least one of said sub passages into two sub-sub passages at a branch point defined by a distal end of said sub passage. The target gas passage also includes at least a number n of switching-gas supply passages connected to respective intermediate positions of said n branch passages.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: January 31, 2012
    Assignee: Shimadzu Corporation
    Inventor: Masanao Furukawa
  • Patent number: 7918244
    Abstract: Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: April 5, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Manu Prakash, Neil Gershenfeld
  • Patent number: 7811521
    Abstract: A testing microchip includes a specimen storage section; a reagent storage section; a reaction section; a testing section for a test of a reaction product obtained from the reaction; a liquid feed control section; and a gas bubble trapping structure. The sections are connected continuously by a series of flow channels. The liquid feed control section stops passing of liquid until a liquid feeding pressure reaches a predetermined pressure, and passes the liquid when the liquid feeding pressure becomes higher than the predetermined pressure; and the gas bubble trapping structure traps a gas bubble in the liquid that flows in the flow channel so that the gas bubble does not flow to the downstream side and only the liquid passes to the downstream side. A testing apparatus that performs testing in the testing section of the testing microchip, wherein the testing microchip is attachably and detachably mounted to the apparatus.
    Type: Grant
    Filed: March 21, 2006
    Date of Patent: October 12, 2010
    Assignee: Konica Minolta Medical & Graphic, Inc.
    Inventors: Yasuhiro Sando, Akihisa Nakajima, Kusunoki Higashino
  • Patent number: 7802591
    Abstract: A microfluidic device comprises first and second inlet passages (13) for respective immiscible fluids, these inlet passages merging into a third passage (8) along which the two fluids flow under parallel laminar flow conditions, the third passage being formed with a constriction or other discontinuity (9) causing the two fluids to form into a flow of alternate segments.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: September 28, 2010
    Assignee: Q Chip Limited
    Inventors: David Anthony Barrow, Nicola Harries, Tyrone Gwyn Jones, Kostas Bouris
  • Patent number: 7784495
    Abstract: An all fluid-based no-moving part micro-mechanical logic family of microfluidic bubble logic devices is constructed from complex sequences of microfluidic channels, microfluidic bubble modulators for programming the devices, and microfluidic droplet/bubble memory elements for chemical storage and retrieval. The input is a sequence of bubbles/droplets encoding information, with the output being another sequence of bubbles/droplets. For performing a set of reactions/tasks, the modulators program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the microfluidic channel sequence, utilizing the generated bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, shift registers, multiplexers, and ring oscillators have been designed and fabricated.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: August 31, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: Manu Prakash, Neil Gershenfeld
  • Publication number: 20100139797
    Abstract: In one embodiment as described in this section, an apparatus for mixing of microfluidic streams on a chip is presented, which comprises a micro-channel and a plurality of magnetic valves on the chip. A guiding magnet produces a proximal magnetic field gradient to exert a force on a bead in a cavity when placed at in a vicinity of the chip. The bead-cavity combination form a magnetic valve. In one embodiment, the mouth of the cavity is tapered so to prevent the magnetic bead from completely blocking the corresponding micro-channel section to enhance the mixing of microfluidic streams at the narrowed fluid path. In one embodiment, magnetically actuated valves direct the flow in a microfluidic system in one of several flow paths wherein the mixing characteristics of the paths are different.
    Type: Application
    Filed: December 6, 2008
    Publication date: June 10, 2010
    Inventor: Emmanuel Delamarche
  • Patent number: 7731910
    Abstract: A microfluidic mixing assembly includes at least first and second liquid sources, a microfluidic manifold, a first capillary valve between the first liquid source and the manifold, and a second capillary valve between the second liquid source and the manifold, wherein the first capillary valve is configured to open and provide a first liquid flow to the microfluidic manifold in response to an external force and the second capillary valves is configured to be opened by the first liquid flow.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: June 8, 2010
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Patrick V. Boyd, Philip Harding
  • Patent number: 7681595
    Abstract: Provided are a microfluidic device and a microfluidic network formed by connecting such microfluidic devices. The microfluidic device can equalize the flow of multiple microfluids in a chamber in parallel to thereby have an equal flow rate when the microfluids transferred through different flow channels join in the chamber having a changing cross-sectional area. The microfluidic device includes: multiple flow channels formed between an upper substrate and a lower substrate to transfer the microfluids and including inlets for injecting the microfluids in one side and fluid stopping surfaces for stopping the flow of the microfluids in the other side; a pressure controlling flow channel for removing a pressure difference between the microfluids; a fluid converging part for converging the microfluids; and a chamber composed of hydrophilic surfaces and hydrophobic surfaces disposed alternately in a flow direction so that the microfluids join and flow in parallel and equal.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: March 23, 2010
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Sung-Jin Kim, Kwang-Hyo Chung, Hyeon-Bong Pyo
  • Publication number: 20090246086
    Abstract: A microfluidic network comprising a plurality of droplet emitters forming droplets of a first fluid in a second fluid immiscible in the first fluid to produce an outlet stream of droplets, wherein each of the emitters are in fluid communication with each other via the network and all have an auto-synchronised droplet formation frequency by hydrodynamic interaction between the emitters is provided. The synchronisation gives a surprisingly narrow droplet size distribution for the network.
    Type: Application
    Filed: October 2, 2006
    Publication date: October 1, 2009
    Inventors: Valessa Barbier, Fabien Frederic Raymond Marie Jousse, Patrick Jean Rene Tabeling, Herve Willaime
  • Patent number: 7534097
    Abstract: A method and apparatus for controlling multi-fluid flow in a micro channel is disclosed. The apparatus has a first inlet for a first fluid; a second inlet for a second fluid; a first outlet; and a second outlet. The micro channel is operatively and fluidically connected to the first inlet, the second inlet, the first outlet and the second outlet. The micro channel is for receiving the first fluid and the second fluid under pressure-driven flow; there being an interface between the first fluid and the second fluid when in the micro channel. The apparatus also includes a pair of electrodes for having a first electric field applied thereto for a controlling the fluid flow velocity of the first fluid along the micro channel.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: May 19, 2009
    Assignee: Nanyang Technological University
    Inventors: Teck Neng Wong, Nam Trung Nguyen, Chun Yang, Chee Kiong John Chai, Kim Tiow Ooi, Cheng Wang, Yan Dong Gao
  • Publication number: 20090090422
    Abstract: The invention relates to a method for treating drops in a microfluid circuit, comprising at least one microchannel (12) through which the drops flow, characterized in that a laser (26) is brought to bear on the interface of said drops in the transport liquid (F3), or on the interface of drops in contact, in order to carry out a sorting of the drops, to form nanodrops from a larger drop or to fuse drops (60, 64) in contact and initiate reactions between the fluids contained in said drops.
    Type: Application
    Filed: May 16, 2007
    Publication date: April 9, 2009
    Inventors: Charles N. Baroud, Jean-Pierre Delville
  • Publication number: 20090078326
    Abstract: Disclosed are compositions and methods for producing movement of liquid across surfaces.
    Type: Application
    Filed: June 14, 2005
    Publication date: March 26, 2009
    Applicant: ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Rohit Rosario, S.Thomas Picraux, Mark Hayes, John Devens Gust, JR., Antonio A. Garcia
  • Publication number: 20080314464
    Abstract: The invention provides a device (1, 301, 501) for producing a spherical segmented flow of fluid, which device includes: a functional fluid conduit (6, 506) arranged to contain a functional fluid (15, 515); at least two carrier fluid conduits (7, 8, 507, 508), each carrier fluid conduit arranged to carry a carrier fluid (16, 514), the functional fluid conduit merging with the carrier fluid conduits at a junction (9) to form an encased flow conduit (9a, 529) thereby permitting functional fluid to be sandwiched (or encased) by the carrier fluid to form an encased flow, the encased flow conduit having a discontinuity (10, 510) therein such that the encased flow forms into a flow of alternate segmented spheres after the discontinuity, wherein the device is provided with a segmented flow conduit (11, 511) downstream of the encased flow conduit, the encased segmented flow conduit being provided with an enlargement (21, 512) in cross-section.
    Type: Application
    Filed: December 19, 2005
    Publication date: December 25, 2008
    Inventors: Robert Huw Davis, Daniel David Palmer
  • Patent number: 7445754
    Abstract: Disclosed is to a device for exchanging minimum amount of the fluid only by using surface tension of the fluid instead of external force like a pump. According to the device, an additional pump and power supply is not needed, thereby the device can be small sized and portable, and not only manufacturing cost decreases and yield increases but the device is hardly out of order.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: November 4, 2008
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Kwang Hyo Chung, Jong Soo Ko, Hyun Chul Yoon, Hae Sik Yang, Hyeon Bong Pyo, Sung Jin Kim, Yun Tae Kim
  • Publication number: 20080257435
    Abstract: A fluid displacement mechanism is disclosed. In an embodiment, first and second cavities are separated by a flexible membrane. The first cavity contains a non-conductive fluid and the second cavity contains a conductive fluid. First and second electrodes are positioned in the first and second cavities respectively such that the application of a voltage between the electrodes causes movement of the membrane by the build up of an electrostatic charge between the membrane and first electrode.
    Type: Application
    Filed: April 7, 2008
    Publication date: October 23, 2008
    Applicant: Microsoft Corporation
    Inventor: Timothy A. Large
  • Publication number: 20070227536
    Abstract: Various embodiments of a breath-activated nebulizer with fluidic control and related methods of using such a nebulizer are disclosed. The nebulizer may include a body comprising a reservoir for holding medication, a nozzle for emitting a jet of pressurized gas, and a fluid conduit in communication with the reservoir for delivery of the medication proximate the jet to produce an aerosol of medication. The nebulizer may also include a nebulizer outlet in communication with an interior of the body for delivery of the aerosol to a patient, a control conduit in fluid communication with the fluid conduit for delivery of a control gas to the fluid conduit to prevent the delivery of the medication proximate the jet, and a fluidic amplifier configured to control the delivery of the control gas to the control conduit.
    Type: Application
    Filed: March 29, 2007
    Publication date: October 4, 2007
    Inventors: David A. Rivera, Steven M. Harrington, Bruce K. Bridges, Neil A. Korneff
  • Patent number: 7171983
    Abstract: Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: February 6, 2007
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Ring-Ling Chien, J. Wallace Parce, Andrea W. Chow, Anne Kopf-Sill
  • Patent number: 7156117
    Abstract: The present invention is directed to methods of controlling the flow of fluids through a microfluidic circuit and, more particularly, to methods of controlling the movement of fluid through a microfluidic circuit using one or more triggerable passive valves. In one embodiment of a method of controlling the flow of fluids through a microfluidic circuit according to the present invention, the microfluidic circuit includes a triggerable valve in series with a passive valve. In a further embodiment of a method of controlling the flow of fluids through a microfluidic circuit according to the present invention, the microfluidic circuit includes first and second triggerable valves in parallel.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: January 2, 2007
    Assignee: Lifescan Scotland Limited
    Inventor: Sebastian Bohm
  • Patent number: 7134453
    Abstract: The invention relates to a microfluidic switch for stopping a liquid flow during a time interval with the following features: the switch has at least one first channel and at least one second channel; the first channel and the second channel have a common end area; the first channel in the end area has a stopping mechanism for stopping of a liquid flow flowing in the first channel; the stopping mechanism can be controlled by means of a liquid flow flowing in the second channel for continuing the liquid flow in the first channel. Transport in the first and the second channel takes place advantageously by the capillarity acting in the channel.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: November 14, 2006
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Ralf Peters, Gert Blankenstein, Holger Bartos, Claus Marquordt
  • Patent number: 7118910
    Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: October 10, 2006
    Assignee: Fluidigm Corporation
    Inventors: Marc Unger, Ian D. Manger, Michael Lucero, Yong Yi, Emily Miyashita-Lin, Anja Weinecke, Geoffrey Facer
  • Patent number: 7111635
    Abstract: A method is provided for fabricating a constriction region in a channel of a microfluidic device. The method includes the steps of introducing a pre-polymer mixture including a monomer, cross-linking agent and photoinitiator into the channel. The pre-polymer mixture is polymerized at a localized area of the channel so as to shrink and solidify the liquid mixture. The solidified and shrunken liquid mixture provides the constriction region in the channel.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: September 26, 2006
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Jeffrey S. Moore, Jaisree Moorthy
  • Patent number: 7082955
    Abstract: A system for conveying fluid through a conduit that creates a strong laminar flow of the material surrounded by a boundary layer flow of the same or a different flowable material, such that long transport distances through dramatic elevation and directional changes can be achieved. Some embodiments of the system include a blower assembly, an inlet conduit, an outlet conduit and a mixing chamber, wherein the mixing chamber includes an outer barrel, an inner barrel and an accelerating chamber. Low pressure gas is supplied to the system by the blower assembly and mixed with particulate material. The gas/material mixture is transported through the mixing chamber into the accelerating chamber and through the outlet conduit. In other embodiments, the particulate material is mixed with the gas in the accelerating chamber.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: August 1, 2006
    Assignee: Ecotechnology, Ltd.
    Inventors: Darin L. Lane, Walter D. Prince, Alan Miller
  • Patent number: 7077152
    Abstract: Systems and methods for metering microfluidic volumes are provided. A discrete plug may be separated from a larger volume of first fluid by injecting a second fluid, such as a gas, into a channel containing the first fluid. The injection of the second fluid to isolate the desired amount of the first fluid may be controlled through timing of flows, visual indicators and/or automated control systems using optical or electrical sensors.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: July 18, 2006
    Assignee: Nanostream, Inc.
    Inventor: Christoph D. Karp
  • Patent number: 7069943
    Abstract: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: July 4, 2006
    Assignee: Cytonome, Inc.
    Inventors: John R. Gilbert, Sebastian Böhm, Manish Deshpande
  • Patent number: 7066207
    Abstract: A system and method for conveying flowable material through a conduit that creates a strong laminar flow of the material surrounded by a boundary layer flow of the same or a different flowable material, such that long transport distances through dramatic elevation and directional changes can be achieved. Some embodiments of the system include a blower assembly, an inlet conduit, an outlet conduit and a mixing chamber, wherein the mixing chamber includes an outer barrel, an inner barrel and an accelerating chamber. Low pressure air is supplied to the system by the blower assembly and mixed with particulate material. The air/material mixture is transported through the mixing chamber into the accelerating chamber and through the outlet conduit. In other embodiments, the particulate material is mixed with the air in the accelerating chamber.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: June 27, 2006
    Assignee: Ecotechnology, Ltd.
    Inventors: Darin L. Lane, Walter D. Prince, Alan Miller