Utilizing Diverse Fluids Patents (Class 137/806)
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Publication number: 20080314464Abstract: The invention provides a device (1, 301, 501) for producing a spherical segmented flow of fluid, which device includes: a functional fluid conduit (6, 506) arranged to contain a functional fluid (15, 515); at least two carrier fluid conduits (7, 8, 507, 508), each carrier fluid conduit arranged to carry a carrier fluid (16, 514), the functional fluid conduit merging with the carrier fluid conduits at a junction (9) to form an encased flow conduit (9a, 529) thereby permitting functional fluid to be sandwiched (or encased) by the carrier fluid to form an encased flow, the encased flow conduit having a discontinuity (10, 510) therein such that the encased flow forms into a flow of alternate segmented spheres after the discontinuity, wherein the device is provided with a segmented flow conduit (11, 511) downstream of the encased flow conduit, the encased segmented flow conduit being provided with an enlargement (21, 512) in cross-section.Type: ApplicationFiled: December 19, 2005Publication date: December 25, 2008Inventors: Robert Huw Davis, Daniel David Palmer
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Patent number: 7445754Abstract: Disclosed is to a device for exchanging minimum amount of the fluid only by using surface tension of the fluid instead of external force like a pump. According to the device, an additional pump and power supply is not needed, thereby the device can be small sized and portable, and not only manufacturing cost decreases and yield increases but the device is hardly out of order.Type: GrantFiled: September 29, 2003Date of Patent: November 4, 2008Assignee: Electronics and Telecommunications Research InstituteInventors: Kwang Hyo Chung, Jong Soo Ko, Hyun Chul Yoon, Hae Sik Yang, Hyeon Bong Pyo, Sung Jin Kim, Yun Tae Kim
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Publication number: 20080257435Abstract: A fluid displacement mechanism is disclosed. In an embodiment, first and second cavities are separated by a flexible membrane. The first cavity contains a non-conductive fluid and the second cavity contains a conductive fluid. First and second electrodes are positioned in the first and second cavities respectively such that the application of a voltage between the electrodes causes movement of the membrane by the build up of an electrostatic charge between the membrane and first electrode.Type: ApplicationFiled: April 7, 2008Publication date: October 23, 2008Applicant: Microsoft CorporationInventor: Timothy A. Large
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Publication number: 20070227536Abstract: Various embodiments of a breath-activated nebulizer with fluidic control and related methods of using such a nebulizer are disclosed. The nebulizer may include a body comprising a reservoir for holding medication, a nozzle for emitting a jet of pressurized gas, and a fluid conduit in communication with the reservoir for delivery of the medication proximate the jet to produce an aerosol of medication. The nebulizer may also include a nebulizer outlet in communication with an interior of the body for delivery of the aerosol to a patient, a control conduit in fluid communication with the fluid conduit for delivery of a control gas to the fluid conduit to prevent the delivery of the medication proximate the jet, and a fluidic amplifier configured to control the delivery of the control gas to the control conduit.Type: ApplicationFiled: March 29, 2007Publication date: October 4, 2007Inventors: David A. Rivera, Steven M. Harrington, Bruce K. Bridges, Neil A. Korneff
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Patent number: 7171983Abstract: Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.Type: GrantFiled: August 11, 2004Date of Patent: February 6, 2007Assignee: Caliper Life Sciences, Inc.Inventors: Ring-Ling Chien, J. Wallace Parce, Andrea W. Chow, Anne Kopf-Sill
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Patent number: 7156117Abstract: The present invention is directed to methods of controlling the flow of fluids through a microfluidic circuit and, more particularly, to methods of controlling the movement of fluid through a microfluidic circuit using one or more triggerable passive valves. In one embodiment of a method of controlling the flow of fluids through a microfluidic circuit according to the present invention, the microfluidic circuit includes a triggerable valve in series with a passive valve. In a further embodiment of a method of controlling the flow of fluids through a microfluidic circuit according to the present invention, the microfluidic circuit includes first and second triggerable valves in parallel.Type: GrantFiled: March 30, 2005Date of Patent: January 2, 2007Assignee: Lifescan Scotland LimitedInventor: Sebastian Bohm
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Patent number: 7134453Abstract: The invention relates to a microfluidic switch for stopping a liquid flow during a time interval with the following features: the switch has at least one first channel and at least one second channel; the first channel and the second channel have a common end area; the first channel in the end area has a stopping mechanism for stopping of a liquid flow flowing in the first channel; the stopping mechanism can be controlled by means of a liquid flow flowing in the second channel for continuing the liquid flow in the first channel. Transport in the first and the second channel takes place advantageously by the capillarity acting in the channel.Type: GrantFiled: January 23, 2004Date of Patent: November 14, 2006Assignee: Boehringer Ingelheim Microparts GmbHInventors: Ralf Peters, Gert Blankenstein, Holger Bartos, Claus Marquordt
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Patent number: 7118910Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.Type: GrantFiled: November 27, 2002Date of Patent: October 10, 2006Assignee: Fluidigm CorporationInventors: Marc Unger, Ian D. Manger, Michael Lucero, Yong Yi, Emily Miyashita-Lin, Anja Weinecke, Geoffrey Facer
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Patent number: 7111635Abstract: A method is provided for fabricating a constriction region in a channel of a microfluidic device. The method includes the steps of introducing a pre-polymer mixture including a monomer, cross-linking agent and photoinitiator into the channel. The pre-polymer mixture is polymerized at a localized area of the channel so as to shrink and solidify the liquid mixture. The solidified and shrunken liquid mixture provides the constriction region in the channel.Type: GrantFiled: October 11, 2002Date of Patent: September 26, 2006Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Jeffrey S. Moore, Jaisree Moorthy
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Patent number: 7082955Abstract: A system for conveying fluid through a conduit that creates a strong laminar flow of the material surrounded by a boundary layer flow of the same or a different flowable material, such that long transport distances through dramatic elevation and directional changes can be achieved. Some embodiments of the system include a blower assembly, an inlet conduit, an outlet conduit and a mixing chamber, wherein the mixing chamber includes an outer barrel, an inner barrel and an accelerating chamber. Low pressure gas is supplied to the system by the blower assembly and mixed with particulate material. The gas/material mixture is transported through the mixing chamber into the accelerating chamber and through the outlet conduit. In other embodiments, the particulate material is mixed with the gas in the accelerating chamber.Type: GrantFiled: June 4, 2003Date of Patent: August 1, 2006Assignee: Ecotechnology, Ltd.Inventors: Darin L. Lane, Walter D. Prince, Alan Miller
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Patent number: 7077152Abstract: Systems and methods for metering microfluidic volumes are provided. A discrete plug may be separated from a larger volume of first fluid by injecting a second fluid, such as a gas, into a channel containing the first fluid. The injection of the second fluid to isolate the desired amount of the first fluid may be controlled through timing of flows, visual indicators and/or automated control systems using optical or electrical sensors.Type: GrantFiled: May 6, 2002Date of Patent: July 18, 2006Assignee: Nanostream, Inc.Inventor: Christoph D. Karp
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Patent number: 7069943Abstract: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.Type: GrantFiled: December 21, 2004Date of Patent: July 4, 2006Assignee: Cytonome, Inc.Inventors: John R. Gilbert, Sebastian Böhm, Manish Deshpande
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Patent number: 7066190Abstract: An air-driven microfluid control device and its method are disclosed. The control device contains an air source, a first inlet, a second inlet, a narrow sector, and an outlet. The air source is connected two the two inlets to produce an airflow. The first inlet connects to the narrow sector, which then connects to the outlet. The air flows through the first inlet and the narrow sector and exits via the outlet. A fluid tunnel connects to the narrows sideways. The second inlet connects to the fluid tunnel so that the air entering the second inlet flows into the fluid tunnel. Through the interaction between the two inlets, pushing and pulling forces can be produced to control the fluid inside the fluid tunnel.Type: GrantFiled: July 15, 2003Date of Patent: June 27, 2006Assignee: Dr. Chip Biotechnology IncorporationInventors: Chien-An Chen, Shun-Chieh Yang
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Patent number: 7066207Abstract: A system and method for conveying flowable material through a conduit that creates a strong laminar flow of the material surrounded by a boundary layer flow of the same or a different flowable material, such that long transport distances through dramatic elevation and directional changes can be achieved. Some embodiments of the system include a blower assembly, an inlet conduit, an outlet conduit and a mixing chamber, wherein the mixing chamber includes an outer barrel, an inner barrel and an accelerating chamber. Low pressure air is supplied to the system by the blower assembly and mixed with particulate material. The air/material mixture is transported through the mixing chamber into the accelerating chamber and through the outlet conduit. In other embodiments, the particulate material is mixed with the air in the accelerating chamber.Type: GrantFiled: October 14, 2003Date of Patent: June 27, 2006Assignee: Ecotechnology, Ltd.Inventors: Darin L. Lane, Walter D. Prince, Alan Miller
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Patent number: 7059351Abstract: A liquid transportation device includes a working board, a working liquid, a liquid channel and a cover board, wherein the liquid channel is formed on a top surface of the working board, the covering board is fully covered the liquid channel, the liquid channel composed of a material substantially tending to the liquid, and the covering board is composed of a material substantially phobic to the liquid. The working liquid flows within the liquid channel in guidance of the deviation of surface tension between the liquid channel to the working liquid, and the covering board to the working liquid, so that the working liquid is transported within the liquid channel without any external power.Type: GrantFiled: December 5, 2005Date of Patent: June 13, 2006Assignee: National Taiwan UniversityInventors: Chin-Chou Chu, Chien-Fu Chen, Chun-Fei Kung, Chien-Cheng Chang, Fan-Gang Tseng
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Patent number: 6901963Abstract: Provided is a micro fluidic device that can control a flow time of micro fluid by using a capillary phenomenon. The micro fluidic device includes: a flow channel for flowing fluid, the flow channel being formed between a top substrate and a bottom substrate or between a top substrate, a bottom substrate, and a middle substrate; a flow blocking surface for stopping a flow of the fluid in the flow channel temporarily; and a hump for delaying the flow formed in the line of continuity with the flow blocking surface. The micro fluidic device of the present research can control the flow time in a simple manner.Type: GrantFiled: December 8, 2003Date of Patent: June 7, 2005Assignee: Electronics and Telecommunications Research InstituteInventors: Sung Jin Kim, Yong Beom Shin, HaeSik Yang, Dae Sik Lee, Kyu Won Kim, Se Ho Park, Yun Tae Kim
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Patent number: 6895983Abstract: An apparatus for dividing the flow of a gas stream and a method for controlling the flow division of a gas stream are disclosed, the apparatus including an inlet conduit for receiving the gas stream, outlet conduits in fluid communication with the inlet conduit for delivering the gas stream, a balancing gas feed conduit in fluid communication with an outlet conduit, a balancing gas feeder in fluid communication with the balancing gas feed conduit, and a balancing gas controller; and the method including the steps of dividing the process gas stream into process gas stream fractions and injecting a balancing gas stream into a process gas stream fraction in an amount sufficient to displace a portion of gas flow from the process gas stream fraction into one or more remaining process gas stream fractions.Type: GrantFiled: September 26, 2002Date of Patent: May 24, 2005Assignee: The Chemithon CorporationInventor: John Chittenden
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Patent number: 6880576Abstract: Microfluidic devices with multiple fluid process regions for subjecting similar samples to different process conditions in parallel are provided. One or more common fluid inputs may be provided to minimize the number of external fluid supply components. Solid materials such as chromatographic separation media or catalyst media is preferably provided in each fluid process region. Solid materials may be supplied to the devices in the form of slurry, with particles retained by porous elements or frits. Different fluid process regions may having different effective lengths, different solid material types or amounts, or may receive different ratios of common fluids supplied to the device. The flow resistances of dissimilar fluid process regions may be balanced passively with the addition of impedance elements in series with each fluid process region.Type: GrantFiled: May 3, 2004Date of Patent: April 19, 2005Assignee: Nanostream, Inc.Inventors: Christoph D. Karp, Stephen D. O'Connor, Eugene Dantsker
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Patent number: 6877528Abstract: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.Type: GrantFiled: June 24, 2002Date of Patent: April 12, 2005Assignee: Cytonome, Inc.Inventors: John Richard Gilbert, Sebastian Böhm, Manish Deshpande
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Patent number: 6866067Abstract: A micro channel unit having a shape designed to reduce a pressure drop when fluid passes through a connecting channel portion is provided. The micro channel unit includes a micro channel with a width of micrometer dimensions through which liquid flows. The micro channel includes a plurality of straight channel portions and connecting channel portions that connect each pair of adjacent straight channel portions. The connecting channel portions are wider than the straight channel portions connected by the connecting channel portions. The use of the micro channel unit can reduce the pressure drop when fluid passes through the connecting channel portions, thereby reducing the amount of power required to drive the fluid flow and further enabling miniaturization of microfluidic devices such as pumps and peripheral devices.Type: GrantFiled: June 27, 2003Date of Patent: March 15, 2005Assignee: Seoul National UniversityInventors: Seokhyun Lim, Haecheon Choi
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Patent number: 6843272Abstract: A device for interrupting or throttling undesired ionic transport through a fluid network is disclosed. The device acts as a fluid valve by reversibly generating a fixed “bubble” in the conducting solvent solution carried by the network. The device comprises a porous hydrophobic structure filling a portion of a connecting channel within the network and optionally incorporates flow restrictor elements at either end of the porous structure that function as pressure isolation barriers, and a fluid reservoir connected to the region of the channel containing the porous structure. Also included is a pressure pump connected to the fluid reservoir. The device operates by causing the pump to vary the hydraulic pressure to a quantity of solvent solution held within the reservoir and porous structure. At high pressures, most or all of the pores of the structure are filled with conducting liquid so the ionic conductance is high.Type: GrantFiled: November 25, 2002Date of Patent: January 18, 2005Assignee: Sandia National LaboratoriesInventors: Joseph S. Schoeniger, Eric B. Cummings, James S. Brennan
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Publication number: 20040216790Abstract: An air-driven microfluid control device and its method are disclosed. The control device contains an air source, a first inlet, a second inlet, a narrow sector, and an outlet. The air source is connected two the two inlets to produce an airflow. The first inlet connects to the narrow sector, which then connects to the outlet. The air flows through the first inlet and the narrow sector and exits via the outlet. A fluid tunnel connects to the narrows sideways. The second inlet connects to the fluid tunnel so that the air entering the second inlet flows into the fluid tunnel. Through the interaction between the two inlets, pushing and pulling forces can be produced to control the fluid inside the fluid tunnel.Type: ApplicationFiled: July 15, 2003Publication date: November 4, 2004Inventors: Chien-An Chen, Shun-Chieh Yang
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Patent number: 6805164Abstract: A fluidic oscillator capable of generating free fluid jets having distinctive, controllable and industrially/commercially useful flow patterns has a switching chamber having an inlet port that allows a pressurized fluid to enter and flow through the oscillator, an exhaust passage having a sidewall that forms one boundary wall of the switching chamber, a container passage having a sidewall that forms the second boundary wall of the switching chamber, a compliance member connected to the distal end of the container passage, and an expansion chamber connected to the distal end of the exhaust passage, with the expansion chamber having an exhaust orifice that allows fluid to flow from the oscillator. In operation, such an oscillator yields a contained fluid jet that issues from the inlet port into the swishing chamber and alternately switches its flow direction between the container and exhaust passages.Type: GrantFiled: December 4, 2002Date of Patent: October 19, 2004Assignee: Bowles Fluidics CorporationInventor: Ronald D. Stouffer
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Patent number: 6779559Abstract: Methods devices and systems that employ non-mechanical valve modules for controlling directing fluid and other material movement through integrated microscale channel network. These non-mechanical valve modules apply forces that counter the driving forces existing through a given channel segment, via fluidly connected channel segments, so as to selectively arrest flow of material within the given channel segment.Type: GrantFiled: November 5, 2003Date of Patent: August 24, 2004Assignee: Caliper Life Sciences, Inc.Inventors: J. Wallace Parce, Andrea W. Chow
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Publication number: 20040144421Abstract: Methods devices and systems that employ non-mechanical valve modules for controllably directing fluid and other material movement through integrated microscale channel networks. These non-mechanical valve modules apply forces that counter the driving forces existing through a given channel segment, via fluidly connected channel segments, so as to selectively arrest flow of material within the given channel segment.Type: ApplicationFiled: November 5, 2003Publication date: July 29, 2004Applicant: Caliper Technologies Corp.Inventors: J. Wallace Parce, Andrea W. Chow
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Patent number: 6767331Abstract: A backload-responsive fluidic switch having high pressure recovery of more than 50% comprises a body member with a power nozzle having a width W and a centerline CL which is adapted to be coupled to a source of fluid under pressure for issuing a jet of fluid along the centerline. A pair of diverging fluid flow passages have a common connection with the power nozzle and respective bounding walls, each respective bounding wall diverging from the centerline no more than about 50°, and a splitter defining respective inner walls of the pair of diverging walls, the splitter being spaced a distance of about 3W from the power nozzle. Inflatable bladder(s) connected to the diverging fluid flow passage(s), and a vent connected to the other of said fluid flow passages.Type: GrantFiled: October 19, 2001Date of Patent: July 27, 2004Assignee: Bowles Fluidics CorporationInventors: Ronald D. Stouffer, Gregory A. Russell, Aland Santamarina
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Patent number: 6695009Abstract: Methods of concentrating materials within microfluidic channel networks by moving materials into regions in which overall velocities of the material are reduced, resulting in stacking of the material within those reduced velocity regions. These methods, devices and systems employ static fluid interfaces to generate the differential velocities, as well as counter-current flow methods, to concentrate materials within microscale channels.Type: GrantFiled: October 30, 2001Date of Patent: February 24, 2004Assignee: Caliper Technologies Corp.Inventors: Ring-Ling Chien, Benjamin N. Wang
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Patent number: 6681788Abstract: Methods devices and systems that employ non-mechanical valve modules for controllably directing fluid and other material movement through integrated microscale channel networks. These non-mechanical valve modules apply forces that counter the driving forces existing through a given channel segment, via fluidly connected channel segments, so as to selectively arrest flow of material within the given channel segment.Type: GrantFiled: January 24, 2002Date of Patent: January 27, 2004Assignee: Caliper Technologies Corp.Inventors: J. Wallace Parce, Andrea W. Chow
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Patent number: 6679279Abstract: A fluidic valve (125, 300, 500, 900, 1000, 1100, 1200, 1300) switches a state of flow of a fluid in a fluid communication channel of a fluid guiding structure (505). Heating a bi-phase valve element (515, 1065, 1215) causes a change a state of the bi-phase valve element from a high viscosity state to a low viscosity state. A bi-phase valve element that clogs the fluid communication channel can be pushed into an expanded portion (135, 320, 520, 915, 1220) of the fluid communication channel by an application of pressure to the fluid while the bi-phase valve element is in the low viscosity state, unclogging the fluid communication channel. A bi-phase valve element can be pushed from a valve element source chamber (550, 1250) into the fluid communication channel by using a pumped fluid entering the source chamber at a pump inlet (551) while the bi-phase valve element is in the low viscosity state, clogging the fluid communication channel.Type: GrantFiled: July 10, 2002Date of Patent: January 20, 2004Assignee: Motorola, Inc.Inventors: Robin Hui Liu, Justin J. Bonanno, Piotr Grodzinski, Randall Stevens
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Patent number: 6662818Abstract: Regulator for precision control of pressure based on a means of measuring pressure differentials. More specifically, the present invention provides a pressure control that tracks a relatively high background pressure, and applies a positive or negative offset to create the small pressure differentials that can be utilized to transport fluids within a capillary network. The present invention is also directed to a method of controlling microfluidic elements (such as donut cavities) with a high degree of precision. In high performance liquid chromatography applications, this is accomplished using tracking pressure regulators to measure and respond to the difference between the liquid pump pressure and the regulated pneumatic pressure.Type: GrantFiled: February 1, 2002Date of Patent: December 16, 2003Assignee: PerSeptive Biosystems, Inc.Inventors: Carlton H. Paul, Guy B. Praria, Jeffrey H. Stokes
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Patent number: 6659118Abstract: A system and method for conveying flowable material through a conduit that creates a strong laminar flow of the material surrounded by a boundary layer flow of the same or a different flowable material, such that long transport distances through dramatic elevation and directional changes can be achieved. Some embodiments of the system include a blower assembly, an inlet conduit, an outlet conduit and a mixing chamber, wherein the mixing chamber includes an outer barrel, an inner barrel and an accelerating chamber. Low pressure air is supplied to the system by the blower assembly and mixed with particulate material. The air/material mixture is transported through the mixing chamber into the accelerating chamber and through the outlet conduit. In other embodiments, the particulate material is mixed with the air in the accelerating chamber.Type: GrantFiled: December 4, 2001Date of Patent: December 9, 2003Assignee: Ecotechnology, Ltd.Inventors: Darin L. Lane, Walter D. Prince, Alan Miller
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Patent number: 6637463Abstract: Methods and apparatus are presented for controlling fluid flow through flow paths with pressure gradient fluid control. Passive fluid flow barriers may be used to act as valves, thereby allowing the flow of fluids through flow paths to be regulated so as to allow fluids to be introduced via a single channel and subsequently split into multiple channels. Flow through the flow paths can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. Each flow path may have multiple segments, at least one of which is designed to balance the pressure drops of the flow paths to provide uniform flow of fluids through the flow paths. The configurations of the wells may also be modified by adding vents or flow dividers to enhance fluid flushing and gas removal capability.Type: GrantFiled: May 10, 2002Date of Patent: October 28, 2003Assignee: BioMicro Systems, Inc.Inventors: Ming Lei, Nils B. Adey, Michael R. McNeely
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Patent number: 6632286Abstract: A process is described for the production of decomposable soluble products from a slurry of solids in which the slurry is convey axially through the reactor and excess liquid is removed radially through the walls of the reactor. The primary example is the hydrolysis of lignocellulosic biomass to form sugars, usually using an acid catalyst. In one variation of the process liquid and possibly steam are added through the inner wall of the reactor to provide additional flow in the radial direction and to control the temperature. Pressures are maintained such that the product stream is thermally quenched due to partial flashing as it leaves the reactor.Type: GrantFiled: March 19, 2001Date of Patent: October 14, 2003Assignee: Trustees of Dartmouth CollegeInventor: Alvin Omar Converse
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Patent number: 6615856Abstract: A method of controlling fluid flow within a microfluidic circuit using external valves and pumps connected to the circuit is disclosed. The external valves and pumps, which are not a part of the microfluidic substrate, control fluid pumping pressure and the displacement of air out of the fluid circuit as fluid enters into the circuit. If a valve is closed, air cannot be displaced out of circuit, which creates a pneumatic barrier that prevents fluid from advancing within the circuit (under normal operating pressures). Applications of this method of fluid control are explained.Type: GrantFiled: August 3, 2001Date of Patent: September 9, 2003Assignee: BioMicro Systems, Inc.Inventors: Michael R. McNeely, Mark K. Spute
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Patent number: 6601613Abstract: Methods of controlling fluid flow through microchannels by use of passive valves or stopping means in the microchannels is presented. The passive valves act as pressure barriers impeding flow of solution past the stopping means until enough force is built up to overcome the force of the pressure barrier. Well planned use of such stopping means acting as passive valves allows the flow of fluids through microchannels to be regulated so as to allow fluids to be mixed or diluted after being introduced via a single channel, or to be split into multiple channels without the need for individual pipetting. Flow through the multiple channels can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. The filling of sister wells or chambers in this manner allows all wells or chambers to undergo reactions in unison. The use of air ducts to prevent trapping of air in the microchannels is also presented.Type: GrantFiled: September 27, 2001Date of Patent: August 5, 2003Assignee: BioMicro Systems, Inc.Inventors: Michael R. McNeely, Arnold R. Oliphant, Mark K. Spute
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Patent number: 6591852Abstract: Methods and apparatus for controlling fluid flow through microchannels by use of passive valves or stopping means comprised of abrupt microchannel widenings in the microchannels are presented. Such passive fluid flow barriers create pressure barriers impeding flow of solution past the passive fluid flow barriers until enough force is built up to overcome the force of the pressure barrier. Use of such stopping means acting as passive barriers or valves allows the flow of fluids through microchannels to be regulated so as to allow fluids to be mixed or diluted after being introduced via a single channel, or to be split into multiple channels without the need for individual pipetting. Flow through the multiple channels can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. The filling of sister wells or chambers in this manner allows all wells or chambers to undergo reactions in unison.Type: GrantFiled: January 30, 2002Date of Patent: July 15, 2003Assignee: BioMicro Systems, Inc.Inventors: Michael R. McNeely, Mark K. Spute, Arnold R. Oliphant
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Publication number: 20030121788Abstract: A dielectric gate and related systems and methods for controlling fluid flow. A dielectric gate includes one or more electrodes coupled between an inlet fluid pathway and an outlet fluid pathway. The electrodes are configured to draw fluid from the inlet fluid pathway to the outlet fluid pathway in a precise manner by using dielectric forces arising from electrical signals applied to the electrodes.Type: ApplicationFiled: December 20, 2001Publication date: July 3, 2003Inventors: Peter Gascoyne, Jon Schwartz, Jody V. Vykoukal, Frederick F. Becker
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Patent number: 6578607Abstract: A diffuser comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includes one or more flow control features. A first flow-control feature comprises one or more appropriately-shaped annular slits through which fluid having a greater momentum than a primary fluid moving through the diffuser is injected into the “boundary layer” near the wall of the diffuser. A second flow control feature comprises one or more annular slits or, alternatively, slots or holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots.Type: GrantFiled: December 10, 2001Date of Patent: June 17, 2003Assignee: Delsys Pharmaceutical Corp.Inventors: Kerry Dennis O'Mara, David Keller, Joseph Thomas McGinn
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Publication number: 20030005967Abstract: Systems and methods for metering microfluidic volumes are provided. A discrete plug may be separated from a larger volume of first fluid by injecting a second fluid, such as a gas, into a channel containing the first fluid. The injection of the second fluid to isolate the desired amount of the first fluid may be controlled through timing of flows, visual indicators and/or automated control systems using optical or electrical sensors.Type: ApplicationFiled: May 6, 2002Publication date: January 9, 2003Applicant: Nanostream, Inc.Inventor: Christoph D. Karp
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Patent number: 6453928Abstract: A device for moving a fluid in a fluidics system. The device may include one or more controllably openable closed chambers. The pressure within the closed chamber(s) is lower than the ambient pressure outside the fluidics system or lower than the pressure within another channel of the fluidic system. The closed chamber(s) is configured for being controllably opened. The chamber (or chambers) is configured such that when a chamber is opened the chamber is in fluidic communication with a flow channel included within the fluidics system. The fluid may be moved into the flow channel or may be moved within the flow channel. The fluid may be a liquid, a gas, a mixture of gases or an aerosol. The fluidics system may include a controller for controlling the opening of a selected chamber or chambers.Type: GrantFiled: January 8, 2001Date of Patent: September 24, 2002Assignee: Nanolab Ltd.Inventors: Shay Kaplan, Amit Shacham
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Patent number: 6450189Abstract: Atomized particles within a desired size range (e.g., 1 micron to about 5 microns) are produced from two immiscible fluids, a first fluid source containing the formulation to be atomized, and a second fluid source which is contained in a pressure chamber surrounding at least the area where the first liquid is to be provided. The invention provides methods for: the production of templates for microfabrication, such as particles that serve as templates for self-assembly of monolayers; the creation of small particles to serve as building blocks for the microassembly of objects; and the use of an atomizate to etch configurations and/or patterns onto the surface of an object by removing a selected portion of the surface.Type: GrantFiled: September 29, 2000Date of Patent: September 17, 2002Assignee: Universidad de SevillaInventor: Alfonso Gañán-Calvo
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Patent number: 6450203Abstract: A method of controlling flow of a driven fluid in a channel, the channel being defined by an encircling wall, the method comprising the steps of sealing the channel with a sealing fluid immiscible in the driven fluid blocking the channel at an initial position, in which the sealing fluid has a first contact angle with the encircling wall and the driven fluid has a second contact angle with the encircling wall and the first contact angle is less than the second contact angle; and moving the sealing fluid in the channel by a force generated outside of the channel.Type: GrantFiled: July 7, 2000Date of Patent: September 17, 2002Assignee: Micralyne Inc.Inventors: Christopher J. Backhouse, Herbert A. Hartshorne
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Publication number: 20020052567Abstract: A backload-responsive fluidic switch having high pressure recovery of more than 50% comprises a body member with a power nozzle having a width W and a centerline CL which is adapted to be coupled to a source of fluid under pressure for issuing a jet of fluid along the centerline. A pair of diverging fluid flow passages have a common connection with said power nozzle and respective bounding walls, each respective bounding wall diverging from the centerline no more than about 50°, and a splitter defining respective inner walls of said pair of diverging walls, the splitter being spaced a distance of about 3W from the power nozzle. Inflatable bladder(s) connected to the diverging fluid flow passage(s), and a vent connected to the other of said fluid flow passages.Type: ApplicationFiled: October 19, 2001Publication date: May 2, 2002Inventors: Ronald D. Stouffer, Gregory A. Russell, Aland Santamarina
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Publication number: 20020036018Abstract: Methods of controlling fluid flow through microchannels by use of passive valves or stopping means in the microchannels is presented. The passive valves act as pressure barriers impeding flow of solution past the stopping means until enough force is built up to overcome the force of the pressure barrier. Well planned use of such stopping means acting as passive valves allows the flow of fluids through microchannels to be regulated so as to allow fluids to be mixed or diluted after being introduced via a single channel, or to be split into multiple channels without the need for individual pipetting. Flow through the multiple channels can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. The filling of sister wells or chambers in this manner allows all wells or chambers to undergo reactions in unison. The use of air ducts to prevent trapping of air in the microchannels is also presented.Type: ApplicationFiled: September 27, 2001Publication date: March 28, 2002Inventors: Michael R. McNeely, Arnold R. Oliphant, Mark K. Spute
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Publication number: 20020003001Abstract: A passive valve for use within microfluidic structures. Surface tension forces developed within microscale channels are used to control flow within the channels. Flow can be halted within a channel until fluid force reaches a predetermined pressure to allow the channel to open.Type: ApplicationFiled: May 23, 2001Publication date: January 10, 2002Inventors: Bernhard H. Weigl, Gerald L. Klein
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Patent number: 6296020Abstract: Methods of controlling fluid flow through microchannels by use of passive valves or stopping means in the microchannels is presented. The passive valves act as pressure barriers impeding flow of solution past the stopping means until enough force is built up to overcome the force of the pressure barrier. Well planned use of such stopping means acting as passive valves allows the flow of fluids through microchannels to be regulated so as to allow fluids to be mixed or diluted after being introduced via a single channel, or to be split into multiple channels without the need for individual pipetting. Flow through the multiple channels can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. The filling of sister wells or chambers in this manner allows all wells or chambers to undergo reactions in unison. The use of air ducts to prevent trapping of air in the microchannels is also presented.Type: GrantFiled: October 13, 1999Date of Patent: October 2, 2001Assignee: BioMicro Systems, Inc.Inventors: Michael R. McNeely, Arnold R Oliphant, Mark K. Spute
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Patent number: 6176676Abstract: Structure with elements includes a main body of the element used in gas stream and a plurality of fluid passage. Each outlet of the fluid passage is opened on surface of the main body. Coolant fluid flows from each outlet through the passage to cover the surface as a film-like fluid. The plurality of fluid passages include first fluid passages and second fluid passages. The coolant fluid flows from the outlet of the first fluid passage along the direction of the gas stream on the surface. On the other hand, the coolant fluid also flows from the outlet of the second fluid passage toward the gas stream neighbored on each outlet of the first fluid passage.Type: GrantFiled: October 20, 1999Date of Patent: January 23, 2001Assignee: Kabushiki Kaisha ToshibaInventors: Kazutaka Ikeda, Akinori Koga, Junji Ishii
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Patent number: 6092982Abstract: Structure with elements includes a main body of the element used in gas stream and a plurality of fluid passage. Each outlet of the fluid passage is opened on surface of the main body. Coolant fluid flows from each outlet through the passage to cover the surface as a film-like fluid. The plurality of fluid passages include first fluid passages and second fluid passages. The coolant fluid flows from the outlet of the first fluid passage along the direction of the gas stream on the surface. On the other hand, the coolant fluid also flows from the outlet of the second fluid passage toward the gas stream neighbored on each outlet of the first fluid passage.Type: GrantFiled: May 23, 1997Date of Patent: July 25, 2000Assignee: Kabushiki Kaisha ToshibaInventors: Kazutaka Ikeda, Akinori Koga, Junji Ishii
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Patent number: 6062261Abstract: A microfabricated device and method for proportioning and mixing electrokinetically manipulated biological or chemical materials is disclosed. The microfabricated device mixes a plurality of materials in volumetric proportions controlled by the electrical resistances of tributary reagent channels through which the materials are transported. The microchip includes two or more tributary reagent channels combining at one or more junctions to form one or more mixing channels. By varying the geometries of the channels (length, cross section, etc.), a plurality of reagent materials can be mixed at a junction such that the proportions of the reagent materials in the mixing channel depend on a ratio of the channel geometries and material properties. Such an approach facilitates voltage division on the microchip without relying on external wiring schemes and voltage division techniques external to the microchip.Type: GrantFiled: December 16, 1998Date of Patent: May 16, 2000Assignee: Lockheed Martin Energy Research CorporationInventors: Stephen C. Jacobson, J. Michael Ramsey
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Patent number: 5931178Abstract: An apparatus and method for performing high speed interruption of the flow of a very fine, high pressure, high speed water jet 12 of the type used to cut foods, paper, and other goods. The water jet 12 is interrupted by a pivotal blocking bar 22 within a blocker housing. The blocking bar 22 is pivoted in a collar 24b to a first desired position out of the path of water jet 12 or to a second desired position for blocking the path of water jet 12. A pivot arm 28, controlled by an output shaft 30 of a rotary actuator 32, controls the rotation of the blocking bar 22. A high pressured airflow is introduced into the device for controlling the exhaustion of blocked water within the device and for cooling the rotary actuator 32.Type: GrantFiled: March 19, 1996Date of Patent: August 3, 1999Assignee: Design Systems, Inc.Inventors: Craig E. Pfarr, Norman A. Rudy, Darren P. Wattles