Enzyme Included In Apparatus Patents (Class 204/403.04)
  • Patent number: 11230727
    Abstract: Detection reagents, multi-analyte test elements, test systems, and multi-analyte measuring methods are provided. In particular, multi-analyte test elements have (1) a first working electrode and first counter electrode pair covered with a first analyte-specific reagent that includes an enzyme, a coenzyme and a first mediator and have (2) a second working electrode covered with a second analyte-specific reagent that includes an enzyme, a coenzyme and a second mediator, where the second mediator is different than the first mediator. The single counter electrode can be used as the counter electrode for both the first and second analyte measurements at their respective working electrodes. Moreover, the mediator concentrations, measurement ranges, and applied potential differences are not the same for each analyte-specific measurement.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: January 25, 2022
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Harvey Buck, Terry A. Beaty, Stacy Hunt DuVall
  • Patent number: 11187667
    Abstract: The present invention includes a body case having a biological sample sensor mounting portion on one end side, a temperature sensor (A) provided on the one end side inside the body case, a measurement portion connected to the biological sample sensor mounting portion, and a control portion connected to the measurement portion. A temperature sensor (B) is provided on one other end side inside the body case, and when measurement is performed by the measurement portion, temperature change amounts in the two end portions are compared using the temperature sensors (A) and (B). Furthermore, a measurement value obtained by the measurement portion is corrected using temperature information from either one of the temperature sensors (A) or (B) that is provided in the end portion on the side where the temperature change is smaller.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: November 30, 2021
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Hirotaka Ochi, Keisuke Matsumura, Hitoshi Fujino, Yohei Hashimoto
  • Patent number: 11060995
    Abstract: The present invention provides for a device and method for the rapid detection (within seconds) of viruses and virions (proteins and nucleic acids) found in novel coronavirus (SARS-CoV-2), Human Immunodeficiency Virus (HIV), and other pandemic viruses. The device can be used at front line, hospitals, clinical laboratories, airports, groceries, homes, and the like. The device can be used as a single probe for single use or home use, or the device integrated into a carrousel or multiple probe magazine for fast detection of multiple samples simultaneously. This carrousel would facilitate multiple testing at times of pandemics when a large number of samples have to be tested in short periods of time.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: July 13, 2021
    Assignee: Texas Tech University System
    Inventors: Gerardine G. Botte, Ashwin Ramanujam
  • Patent number: 11017890
    Abstract: An analyte measurement system includes one or more handheld analyte meters and/or measurement devices and a means for collecting data, preserving data integrity, and uniquely identifying patient data received from multiple sources. For example, provided herein is a means to uniquely identify patients and their data when the data is collected from one or more measurement devices. By providing a way to allow the patients to use multiple sources to collect data, the system described herein provides patients with more flexibility, which should encourage better compliance to protocols. Further, by having a way to uniquely identify patients' data without requiring a patient to only use one analyte meter, for example, data can be centralized and analysis can be done with more assurance that all of the patient's data is being considered in the analyses.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: May 25, 2021
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Daniel M. Bernstein, Gary A. Hayter, Timothy C. Dunn, Mani Gopal, Eric Davis, Brittany K. Bradrick, Todd Winkler
  • Patent number: 10907189
    Abstract: The invention describes a method of determining the presence of acute cerebral ischaemic disorder in a subject comprising: a. measuring the concentration of one or more purines in a body fluid of the subject, the purines being selected from adenosine, inosine, hypoxanthine, xanthine and ATP, and b. comparing the measured concentration with a threshold concentration of the one or more purines, wherein the threshold concentration is preferably in the range 5 ?M to 15 ?M and wherein a measured concentration higher than the threshold concentration indicates the presence of acute ischaemic disorder. Also is described a method of determining the absence of an acute cerebral disorder in a subject comprising: a. measuring the concentration of one or more purines in a body fluid of the subject, the purines being selected from adenosine, inosine, hypoxanthine, xanthine and ATP, and b.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: February 2, 2021
    Assignee: SARISSA BIOMEDICAL LIMITED
    Inventors: Nicholas Dale, Chris Imray, Faming Tian
  • Patent number: 10763681
    Abstract: A system and method is described for rapid charging and power management of a battery for a meter. A charger component is operably associated with the meter and is capable of executing a rapid charge algorithm for a rechargeable battery. The algorithm includes monitoring for a connection to an external power source and implementing a charging routine of a battery at a first charge rate and then at a second charge rate. The second charge rate is lower than the first charge rate. A temperature rise in the rechargeable battery due to the first charge rate has a negligible heat transfer effect on the fluid sample. The meter can also include a power switch for controlling current flow to a battery fuel gauge. The power switch is open when the meter enters into a sleep mode. The state of battery charge is determined after the meter exits the sleep mode.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: September 1, 2020
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Igor Gofman, Jun Chen
  • Patent number: 10743813
    Abstract: Disclosed is a postprandial glucose-measuring device for preventing the development of or reversing T2D. Included are methods for using the device as well as better use for invasive and noninvasive glucose meters. Further disclosed are novel exercise-sensitizing compositions useful for managing blood glucose levels in Type-2 diabetics with minimal risk of hypoglycemia. The disclosed glucose meters allow a user to also measure exercise and meal size—all with relatively instant feedback—more effectively than having to track the complexity posed by labels, glycemic index and calories. Also disclosed is integration of glucose-measuring devices with smartphones and health monitoring technology to make possible safe and effective interpretation of postprandial glucose readings by a patient to control or reverse Type-2 diabetes.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: August 18, 2020
    Inventors: Rattan Nath, Shefali Vyas
  • Patent number: 10724985
    Abstract: A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: July 28, 2020
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Huan-Ping Wu, Christine D. Nelson
  • Patent number: 10690617
    Abstract: A system for the electrochemical detection of ketone levels includes a test strip including an electrode and a counter electrode, the electrode and counter electrode located in a sample reception area. The system further includes a coating on one of the electrode and counter electrode, the coating including a mediator for ketones. Optionally, the mediator is ferricyanide.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: June 23, 2020
    Assignee: Polymer Technology Systems, Inc.
    Inventors: Gary L. Hughes, Aniruddha Patwardhan
  • Patent number: 10219730
    Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: March 5, 2019
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Fei Mao, Adam Heller
  • Patent number: 10202327
    Abstract: A catalyst system includes a complex having formula I which advantageously has a sterically protecting N-heterocyclic carbene (NHC) carbene-pyridine ligand to handle harsh reactions conditions than many prior art catalysts: wherein M is a transition metal; o is 0, 1, 2, 3, or 4; R1 is a C1-6 alkyl, a C6-18 aryl, or an optionally substituted C5-18 heteroaryl. In a refinement, R1 is methyl, ethyl, butyl, n-propyl, isopropyl, n-butyl, sec-butyl, or t-butyl; R2, R3, R3? are independently an optionally substituted C1-6 alkyl, halo (e.g., Cl, F, Br, etc), NO2, an optionally substituted C6-18 aryl, or an optionally substituted C5-18 heteroaryl; R4, R4? are independently an optionally substituted C1-6 alkyl, halo, NO2, an optionally substituted C6-18 aryl, or an optionally substituted C5-18 heteroaryl; and X? is a negatively charge counter ion and L1, L2 are each independently a neutral ligand.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: February 12, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Travis J. Williams, Zhiyao Lu, Ivan Demianets
  • Patent number: 10180420
    Abstract: A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: January 15, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Klaus Andreas Bauer-Espindola, Carina Horn, Michael Marquant, Christine Nortmeyer, Volker Unkrig
  • Patent number: 10144949
    Abstract: A system for electrochemically detecting AST and ALT includes a first sampler for producing pyruvate from ALT and a second sampler for producing pyruvate from AST. The system further includes an electrochemical test strip for receiving processed samples from the first and second samplers, the processed samples containing pyruvate. The system further includes a meter for reading the electrochemical test strip and indicating an amount of AST and ALT in the sample.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: December 4, 2018
    Assignee: Polymer Technology Systems, Inc.
    Inventors: Gary L. Hughes, Aniruddha Patwardhan
  • Patent number: 10073991
    Abstract: Systems and methods of making a diagnostic test strip, the method including marking a machine-readable pattern onto the diagnostic test strip which contains information that allows a meter designed to work with the test strip to convert raw signal data from the diagnostic test strip into a meaningful concentration value for an analyte of interest. The method further includes printing the machine-readable pattern having a modified based code that is different from a base code of the diagnostic test strip being produced, wherein the modified based code is based on a strip geometry parameter, a chemistry parameter or both the strip geometry and chemistry parameters that are measured for the diagnostic test strip.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: September 11, 2018
    Assignee: Trividia Health, Inc.
    Inventor: Stephen Davies
  • Patent number: 9713440
    Abstract: Presented herein is a modular analyte measurement system having a replaceable strip port module that releasably connects and operably couples with an analyte meter. Embodiments of the present invention also relate to modular components of the analyte measurement system. In one aspect, there is provided a replaceable strip port module having a strip port and electrical interface for removably and electrically coupling with an analyte meter. In another aspect, there is provided an analyte meter that includes a processor and electrical interface for removably and electrically coupling with replaceable strip port modules. Methods of configuring the analyte measurement system and methods of determining an analyte meter with the analyte measurement system are also provided.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: July 25, 2017
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Marsha Kaye Hurd, Michael Isherwood
  • Patent number: 9702848
    Abstract: We propose a procedure for the determination of lactic acid or lactate in biological fluids, which is simple and low cost with respect to the known methodologies. This procedure can be used by unskilled personnel and it can be implemented in disposable test strips and portable measure devices. The procedure is based on the photochemical reaction of lactic acid with Fe(III), which is reduced to Fe(II) when irradiated with UV light. The Fe(II), produced proportionally to the amount of lactate in the sample, is determined electrochemically or using its reaction with a colored complexing agent, such as 1,10-phenanthroline, and determined by spectrophotometry. This method is advantageous both for the low cost of the reagents employed, and for their short and long term stability.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: July 11, 2017
    Assignee: POWER FIT S.r.l.
    Inventors: Emilia Bramanti, Fabrizio Zucchini, Massimo Onor, Vincenzo Di Muro
  • Patent number: 9562874
    Abstract: This invention relates to mutagenized redox oxidase enzymes used to design enzyme electrodes with improved interference characteristics in the presence of mediator and oxygen in the assay. This recombinant modified enzyme has enhanced capability to transfer electrons to redox mediator instead of its natural electron acceptors such as O2, NAD, NADP, etc., which will improve the assay performance with less interference and higher sensitivity.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: February 7, 2017
    Assignee: Abbott Point of Care Inc.
    Inventors: Glenn Martin, G. Bruce Collier, Dan Wang
  • Patent number: 9423374
    Abstract: Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether a counter or reference electrode is causing an error by monitoring the working electrodes and flagging an error if the signal outputs of the working electrodes do not meet certain thresholds.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: August 23, 2016
    Assignee: LifeScan Scotland Limited
    Inventors: Stephen Mackintosh, Antony Smith
  • Patent number: 9411614
    Abstract: Systems and methods provide re-configurable functionality within components of I/O devices without the need of disconnecting the components from each other. For example, in certain embodiments, when certain types of components are connected to each other, certain functionality sets within the components may be activated to provide combined functionality sets between the components. The combined functionality sets may, for example, be preferred functionality sets to be used when the particular types of components are connected to each other. Furthermore, in certain embodiments, functionality activation keys may be physically inserted into (or electronically communicated to) the components of the I/O device to activate certain functionality sets within the component into which the functionality activation key is inserted (or electronically communicated to), as well as within the other components of the I/O device to which the component is connected.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: August 9, 2016
    Assignee: Rockwell Automation Technologies, Inc.
    Inventors: Robert J. Kretschmann, David S. Wehrle, Joseph G. Vazach, Gregg M. Sichner
  • Patent number: 9404888
    Abstract: Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, the method includes detecting a presence of a sample in an electrochemical sensor including two electrodes. A fill time of the sample is determined with the two electrodes and a correction factor is calculated in view of at least the fill time. The method also includes reacting an analyte that causes a physical transformation of the analyte between the two electrodes. A concentration of the analyte can then be determined in view of the correction factor with the same two electrodes. Systems and devices that take advantage of the fill time to make analyte concentration determinations are also provided.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: August 2, 2016
    Assignee: LifeScan, Inc.
    Inventors: Ronald C. Chatelier, Alastair M. Hodges
  • Patent number: 9182367
    Abstract: The electroanalytical method for determination of phenols is a method for determining the concentration of phenolic compounds and their chloro-derivatives, on the surface of a glassy carbon electrode (GCE) by cyclic voltammetry (CV) and/or square-wave stripping voltammetry (SWASV) using a redox active polymer film that is formed on the surface of the GCE when the electro-polymerization potential is reached. The electroanalytical method comprises contacting an aqueous sample containing a phenolic compound(s) with an electrode assembly having a working electrode; generating a voltammogram of the analyte by varying an applied accumulation potential or applied potential, and measuring the size of voltammogram peaks corresponding to a redox-active polymeric film that develops at the working electrode at the electro-polymerization potential in order to determine the concentration of the phenolic compound.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: November 10, 2015
    Assignee: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
    Inventors: Abdel-Nasser Metwally Aly Kawde, Mohamed Aly Morsy, Nurudeen A. Odewunmi
  • Patent number: 9121002
    Abstract: A porous electrochemical electrode is made up of a solid cellular material provided in the form of a semi-graphitized carbon monolith comprising a hierarchized porous network free of mesopores and including macropores with a mean dimension dA of 1 ?m to 100 ?m, and micropores with a mean dimension dI of 0.5 nm to 2 nm, said macropores and micropores being interconnected. In said electrode, the macropores contain at least one electroactive species in direct contact with the semi-graphitized carbon that makes up the surface of the macropores. The invention also relates to a method for preparing such an electrode as well as to the use thereof as a biosensor or for manufacturing a biopile.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: September 1, 2015
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Nicolas Mano, Victoria Flexer, Nicolas Brun, Rénal Backov
  • Patent number: 9106019
    Abstract: Systems and methods provide re-configurable functionality within components of I/O devices without the need of disconnecting the components from each other. For example, in certain embodiments, when certain types of components are connected to each other, certain functionality sets within the components may be activated to provide combined functionality sets between the components. The combined functionality sets may, for example, be preferred functionality sets to be used when the particular types of components are connected to each other. Furthermore, in certain embodiments, functionality activation keys may be physically inserted into (or electronically communicated to) the components of the I/O device to activate certain functionality sets within the component into which the functionality activation key is inserted (or electronically communicated to), as well as within the other components of the I/O device to which the component is connected.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: August 11, 2015
    Assignee: ROCKWELL AUTOMATION TECHNOLOGIES, INC.
    Inventors: Robert J. Kretschmann, David S. Wehrle, Joseph G. Vazach, Gregg M. Sichner
  • Publication number: 20150136615
    Abstract: Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a first test voltage between a reference electrode and a second working electrode and applying a second test voltage between the reference electrode and a first working electrode; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing an analyte is applied to the test strip; measuring a fifth test current at the first working electrode; estimating a hematocrit-corrected analyte concentration from the first, second, third, fourth and fifth test currents; and annunciating the hematocrit-corrected analyte concentration.
    Type: Application
    Filed: January 27, 2015
    Publication date: May 21, 2015
    Inventors: Michael MALECHA, Adam CRAGGS
  • Publication number: 20150129424
    Abstract: Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, a sample including an analyte is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and a measurement of a parameter correlating to changes in a physical property of the sample analyzing device is calculated. A concentration of the analyte in view of the parameter correlating to a change in the physical property can then be determined. Systems and devices that take advantage of the parameter correlating to changes in a physical property to make analyte concentration determinations are also provided.
    Type: Application
    Filed: January 12, 2015
    Publication date: May 14, 2015
    Inventors: Ronald C. Chatelier, Alastair M. Hodges
  • Publication number: 20150125938
    Abstract: An liquid sample measuring system includes a measuring device including a measuring section which measures biological information from liquid sample of a living subject within a housing in which a biosensor, on which the liquid sample of the biological body is deposited, is detachably mounted and a movement measuring section which measures movement information of the housing within the housing, and an administrating device including a movement determining section which determines whether or not a degree of the movement of the housing is within an allowable range by analyzing the movement information received from the measuring device.
    Type: Application
    Filed: December 26, 2012
    Publication date: May 7, 2015
    Applicant: Panasonic Healthcare Co., Ltd.
    Inventors: Noriyoshi Terashima, Teppei Shinno, Masataka Nadaoka, Yoshimasa Oda
  • Patent number: 8992751
    Abstract: The present invention relates to test strips and preparation method thereof. More particularly, the present invention relates to a test strip comprising: (a) an insulating substrate; (b) an electrode system disposed on the insulating substrate; (c) an insulation layer disposed on the electrode system, in which an accommodation space is disposed at one side of the insulation layer for exposing a part of the electrode system to carry out an electrochemical reaction of an analyte; and (d) a gel, disposed in the accommodation space and formed by dissolving a reactive enzyme reacting with the analyte in a hydrogel and being cured.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: March 31, 2015
    Assignee: Compose Element Limited
    Inventor: Tsu-Tai Lin
  • Publication number: 20150083591
    Abstract: The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood. In another aspect, fast scan rates may reduce the hematocrit effect.
    Type: Application
    Filed: September 24, 2014
    Publication date: March 26, 2015
    Applicant: Bayer HealthCare LLC
    Inventor: Huan-Ping Wu
  • Patent number: 8980074
    Abstract: A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: March 17, 2015
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventors: Shoji Miyazaki, Hiroyuki Tokunaga, Masaki Fujiwara, Eriko Yamanishi
  • Publication number: 20150068893
    Abstract: A biosensor test device of this disclosure includes a biosensor test strip and biosensor monitor connecting with the biosensor test strip. The biosensor test strip includes a base layer and at least one test section. The test section includes a first electrode, a second electrode, a first track, a second track, a first contact pad, a second contact pad and a reaction zone formed on a base layer. The first track is electrically connected to both the first electrode and the first contact pad. The second track is electrically connected to both the second electrode and the second contact pad. The reaction zone is coated with reagents which contact at least one of the first electrode or the second electrode.
    Type: Application
    Filed: September 10, 2014
    Publication date: March 12, 2015
    Inventors: JEN-FANG LEE, Kuan-Chih Huang
  • Publication number: 20150068894
    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 12, 2015
    Inventors: Ayub Khattak, Clinton Sever
  • Publication number: 20150060272
    Abstract: Devices to detect detecting endotoxin (lipopolysaccharide or LPS) and/or 1-3-?-D-glucan (beta glucan or BG) using substrates including electrogenic mediators for amperometric detection are provided herein. Substrates include an amine group as well as one or more substituted organic rings, such as a phenol. Devices include cartridges for detecting LPS or BG simultaneously using dual detection techniques.
    Type: Application
    Filed: November 14, 2014
    Publication date: March 5, 2015
    Inventors: Richard Andrew Blidner, Albert Gutes-Regidor, Ray R. Radtkey
  • Patent number: 8956518
    Abstract: An electrochemical sensing apparatus and methods are provided. In one embodiment, an apparatus is provided having a carrier that supports an electrochemical module and that communicates between electrodes on the electrochemical module and an analyte measurement device.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: February 17, 2015
    Assignee: LifeScan, Inc.
    Inventors: Garry Chambers, Alastair M. Hodges, Ronald C. Chatelier
  • Patent number: 8945359
    Abstract: The invention provides a flavin-binding glucose dehydrogenase exhibiting reduced fluctuation of activity depending on temperature environment, and a method for measuring glucose concentration using the flavin-binding glucose dehydrogenase. The flavin-binding glucose dehydrogenase has the following properties (1) to (3): (1) activity: which exhibits glucose dehydrogenase activity in the presence of an electron acceptor; (2) substrate specificity: which exhibits an activity of 10% or less against maltose, D-galactose, D-fructose, sorbitol, lactose and sucrose when the activity against D-glucose is defined as 100%; and (3) temperature characteristics: which exhibits lower fluctuation of activity in a wide temperature range of 10 to 50° C.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: February 3, 2015
    Assignee: Ikeda Food Research Co., Ltd.
    Inventors: Michinari Honda, Sayaka Taki, Ryo Takenaka
  • Publication number: 20150027907
    Abstract: Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 29, 2015
    Inventors: Ronald C. Chatelier, Dennis Rylatt, Linda Raineri, Alastair M. Hodges
  • Patent number: 8940153
    Abstract: A test sensor reagent for measuring the concentration of analytes in body fluids includes cellulose polymers for improving the stability of the test sensor and reducing the total assay time. The test sensor reagent also includes an enzyme, an electron transfer mediator and a rheological additive.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: January 27, 2015
    Assignee: Bayer Healthcare LLC
    Inventors: Amy H. Chu, Andrew J. Edelbrock, Hope G. Spradlin
  • Patent number: 8940141
    Abstract: An electrochemical-based analytical test strip for the determination of an analyte (e.g., glucose) in a bodily fluid sample (such as a whole blood sample) includes an electrically insulating base layer and a patterned conductor layer (for example, a gold patterned conductor layer) disposed over the electrically-insulating layer. The patterned conductor layer includes at least one electrode with the electrode having electrochemically inert areas and an electrochemically active area(s). Moreover, the electrochemically inert areas and electrochemically active area(s) are of a predetermined size and a predetermined distribution such that electrochemical response of the electrode during use of the electrochemical-based analytical test strip is essentially equivalent to a predetermined electrochemical response.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: January 27, 2015
    Assignee: Lifescan Scotland Limited
    Inventors: Gavin Macfie, Craig Redpath, James Iain Rodgers, Neil Whitehead
  • Patent number: 8940138
    Abstract: The present biosensor system prevents a measurement error caused by the temperature of the environment in use. A biosensor system 100 includes a measuring instrument 101 having an operation part 306, and a sensor chip 200 insertable into and removable from the measuring instrument 101 and which accepts a blood sample. The sensor chip 200 includes a measurement part 41 that acquires Data a related to the concentration of an analyte in a blood sample based on the amount of electric current that flows in the sample due to a reaction in which an oxidoreductase with the analyte used as a substrate is involved, and a measurement part 42 that acquires, from the sample, Data b for temperature correction of Data a. The operation part 306 determines the concentration of the analyte in the sample, corrected according to the temperature of the sample based on Data a and Data b.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: January 27, 2015
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventor: Masaki Fujiwara
  • Publication number: 20150001071
    Abstract: A bio-fluid test strip includes a fluid receiving area and a contact pad area for interfacing with a fluid sensing device. The test strip includes a fluid sensing electrodes and a first temperature sensing resistor in the fluid receiving area. The test strip further includes a second temperature sensing resistor in the contact pad area. The first and second temperature sensing resistors together provide an indication of the temperature difference between the fluid sensing area and ambience.
    Type: Application
    Filed: June 27, 2013
    Publication date: January 1, 2015
    Inventors: Olivier Le Neel, Suman Cherian
  • Patent number: 8916036
    Abstract: An analyte test instrument that has a test strip circuitry that can be configured using information provided by a calibration strip to perform assays with test strips having two electrodes and test strips having three electrodes. The analyte test instrument of this invention comprises: (a) a test port for receiving a test strip; (b) a microprocessor for executing instructions downloaded into the analyte test instrument; (c) a test strip circuit capable of having a plurality of configurations, the configurations being set by the microprocessor, whereby an assay can be performed using the test strip.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: December 23, 2014
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Yi Wang, Shridhara Alva Karinka, Gurdial Sanghera
  • Patent number: 8906211
    Abstract: Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: December 9, 2014
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Tianmei Ouyang, Zenghe Liu
  • Patent number: 8888972
    Abstract: The present invention provides there is provided an electrochemical biosensor electrode structure that includes: a working electrode and a reference electrode used as electrodes for sample measurement being arranged separately from each other in lengthwise direction of a sample insertion path, the working electrode and the reference electrode each having at least one projection and at least one recess alternately arranged on a portion thereof corresponding to the sample insertion path, the projection of the working electrode being correspondingly adjacent to the recess of the reference electrode, the recess of the working electrode being correspondingly adjacent to the projection of the reference electrode; and at least two sample recognition electrodes used as electrodes for sample recognition being separated from each other and arranged adjacent and parallel to the working electrode and the reference electrode.
    Type: Grant
    Filed: May 18, 2009
    Date of Patent: November 18, 2014
    Assignee: Center for Integrated Smart Sensors Foundation
    Inventors: Young Tae Lee, Seungro Lee
  • Patent number: 8888974
    Abstract: A biosensor includes a working electrode 101, a counter electrode 102 opposing the working electrode 101, a working electrode terminal 103 and a working electrode reference terminal 10 connected to the working electrode 101 by wires, and a counter electrode terminal 104 connected to the counter electrode 102 by a wire. By employing a structure with at least three electrodes, it is possible to assay a target substance without being influenced by the line resistance on the working electrode side.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: November 18, 2014
    Assignee: Panasonic Healthcare Holdings, Co., Ltd
    Inventors: Hiroya Ueno, Junji Nakatsuka
  • Patent number: 8888975
    Abstract: A biosensor includes a working electrode 101, a counter electrode 102 opposing the working electrode 101, a working electrode terminal 103 and a working electrode reference terminal 10 connected to the working electrode 101 by wires, and a counter electrode terminal 104 connected to the counter electrode 102 by a wire. By employing a structure with at least three electrodes, it is possible to assay a target substance without being influenced by the line resistance on the working electrode side.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: November 18, 2014
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventors: Hiroya Ueno, Junji Nakatsuka
  • Publication number: 20140332414
    Abstract: A disposable electrochemical test sensor designed to facilitate sampling of fluid samples. It has a fluid chamber having a novel extra wide sampling entrance, but no additional air escape vent. The chamber provides a reservoir from which a sample fluid can be drawn into the chamber through capillary action. The sampling entrance provided can draw fluid into the chamber through any part of the opening, allowing easy targeting the samples with small volume, picking up smeared samples, and added tolerance to users who jam the tip of the sensor into users' finger. The sampling entrance also serves as air escape vent. Such one opening sensor alleviates over-flow issue often encountered in convenient sensors.
    Type: Application
    Filed: May 9, 2013
    Publication date: November 13, 2014
    Applicant: CHANGSHA SINOCARE INC.
    Inventors: Hongli Che, Shaobo Li
  • Publication number: 20140326599
    Abstract: An electrochemical test sensor for detecting the analyte concentration of a fluid test sample includes a base, a dielectric layer, a reagent layer, a light guide area, and a lid. The base provides a flow path for the test sample haying on its surface a counter electrode and a working electrode adapted to electrically communicate with a detector of electrical current. The dielectric layer forms a dielectric window therethrough. The reagent layer includes an enzyme that is adapted to react with the analyte. The lid is adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the test sample thereto. The light guide area transmits light towards the capillary space.
    Type: Application
    Filed: July 15, 2014
    Publication date: November 6, 2014
    Inventors: Allen J. Brenneman, Dan O'Sullivan
  • Patent number: 8871069
    Abstract: A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w/w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one ?S value responsive to at least one error parameter.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: October 28, 2014
    Assignee: Bayer HealthCare LLC
    Inventors: Amy H. Chu, Huan-Ping Wu, Boru Zhu
  • Publication number: 20140262828
    Abstract: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventor: AgaMatrix, Inc.
  • Patent number: 8834703
    Abstract: Apparatus and methods are described for preparing, maintaining, and stabilizing sensors. The apparatus and methods for preparing sensors for use are utilized in advance of the sensor being removed from a sealed, sterilized package. The apparatus include packaging materials having electrical circuits capable of stabilizing a sensor to prepare the sensor for use. The methods for preparing a sensor for use includes methods of providing a solution to a sterilized packaging that contains a sensor connected to a sensor activating circuit, activating the circuit, and allowing the sensor to stabilize. These methods can be performed without compromising the packaging. The apparatus for stabilizing a sensor that is in use include a circuit connectable to the sensor that provides a signal to the sensor that prevents the sensor from becoming destabilized when disconnected from a monitoring device.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: September 16, 2014
    Assignee: Edwards Lifesciences Corporation
    Inventors: Michael Higgins, Mark Konno, Todd Fjield
  • Patent number: RE45384
    Abstract: An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: February 24, 2015
    Assignee: Bayer HealthCare LLC
    Inventors: Matthew K. Musho, J. Oakey Noell, Andrew J. Edelbrock, Dijia Huang