Disposable Apparatus Or Apparatus Having Removable Section (e.g., Removable Cartridge, Etc.) Patents (Class 204/403.02)
  • Patent number: 10428375
    Abstract: A nucleic acid amplification and detection apparatus, including: a support configured to receive a plurality of reaction vessels containing respective samples of one or more nucleic acids to be amplified, the support being rotatable about an axis of rotation and the reaction vessels being received in the support at respective receiving locations distributed about the axis of rotation; a temperature control component thermally coupled to the support and configured to control the temperature of the support in order to amplify the nucleic acids contained in the reaction vessels while received in the support; one or more measurement components configured to measure one or more characteristics of the nucleic acids within the reaction vessels at respective measurement locations distributed about the axis of rotation; an actuator coupled to the support and configured to rotate the support about the axis of rotation; and a sample position controller coupled to the actuator and being configured to rotate the support a
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: October 1, 2019
    Assignee: AXXIN PTY LTD
    Inventor: William Robb Hopper
  • Patent number: 10386351
    Abstract: Methods and sensors for detection and quantification of one or more analyte in a test sample are described. A response profile of a gas sensor to a control sample of a known interrogator gas is determined. The gas sensor is exposed to a test sample then to a second sample comprising the known interrogator gas, and a test sample response profile of the gas sensor is determined. One or more test sample sensor response profiles are compared with one or more control sensor response profiles for detecting, identifying, and quantifying one or more analytes in the test sample.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: August 20, 2019
    Assignee: NANOHMICS, INC.
    Inventors: Steve M. Savoy, Kyle W. Hoover, Daniel R. Mitchell, Jeremy J. John, Chris W. Mann, Alexander P. Greis
  • Patent number: 10364452
    Abstract: Methods, systems, and devices are disclosed for providing test strip electrochemical sensors for rapid quantitative analysis of analytes in physiological fluids. In one aspect, an electrochemical sensor includes a substrate; an electrode contingent including a first electrode having a coating of carbon nanotubes (CNTs) and a second electrode on the substrate; and an entrapment layer formed on the first electrode to attach an enzymatic substance capable of causing a redox reaction in the presence of a target analyte of a fluid sample which produces a redox-active product, in which the entrapment layer is structured to include a conductive polymer film that is reversibly dopable to conduct charge carriers across the entrapment layer and at the first electrode. For example, the electrochemical sensor can be provided on a disposable test strip to quantify L-DOPA levels in whole blood, plasma, or serum samples.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: July 30, 2019
    Assignees: The Regents of the University of California, Biolinq Incorporated
    Inventors: Joseph Wang, Irene Litvan, Joshua Ray Windmiller
  • Patent number: 10209243
    Abstract: Disclosed is a device (100) for cardiac electrophysiology screening comprising a substrate (10) comprising a cavity (42), said substrate carrying a deformable layer (32) extending over said cavity (42), wherein a portion of said deformable layer (32) covers said cavity and acts as a membrane over said cavity (32), said portion having a surface comprising a pattern of grooves (44) and carrying a multi-electrode structure (110, 110?); and a plurality of cardiomyocytes (130) assembled in at least some of said grooves (44). A method of manufacturing such a device (100) is also disclosed.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: February 19, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Ronald Dekker, Anja Van De Stolpe, Berent Jan Van Meer, Saeed Khoshefetrat Pakazad, Angel Savov
  • Patent number: 10156540
    Abstract: A test strip for biological component measurement includes a substrate. A pair of a working electrode and a counter electrode, a sensor unit that produces an electrochemical reaction with a bodily fluid of a measurement subject and produces a change in electrical characteristics, a resistance portion having an electrical resistance expressing attribute information including a sensitivity of the test strip, and a pair of wires connected to both ends of the resistance portion are provided on the substrate. The resistance portion has a plurality of narrow patterns, each having a resistivity and provided so as to be distanced from each other. An end portion of each narrow pattern is near another narrow pattern. A substantially circular pattern is provided to overlap locations where the end portions of the narrow patterns are near each other, enabling the end portions to conduct with each other.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: December 18, 2018
    Assignee: OMRON HEALTHCARE CO., LTD.
    Inventors: Kenichiro Zaitsu, Muneo Tokita, Satoshi Nakajima
  • Patent number: 10067082
    Abstract: A biosensor (102) for determining the presence or amount of a substance in a sample and methods of use of the biosensor (102) are provided. The biosensor (102) for receiving a user sample to be analyzed includes a mixture for electrochemical reaction with an analyte. The mixture includes an enzyme, a mediator and an oxidizable species as an internal reference.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: September 4, 2018
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Greg P. Beer, Huan-Ping Wu, Kin-Fai Yip
  • Patent number: 10042006
    Abstract: A number of illustrative variations may include a method of estimating battery health including using a charging resistance equivalent.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: August 7, 2018
    Assignee: GM Global Technology Operations LLC
    Inventors: Xinyu Du, Yilu Zhang, Mark J. Rychlinski
  • Patent number: 10024858
    Abstract: This disclosure describes the development of a sample preparation, measurement, and analysis method that permits accurate characterization of red blood cells, platelets, and white blood cells, including a 3-part differential of the white blood cells count, to be performed on small volumes of a biological sample. This method is compatible with compact and portable instrumentation that permits the sample collection to be performed in a subject's home and analysis to be performed elsewhere by transmission of the data to a laboratory or doctor's office.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: July 17, 2018
    Assignees: TAHOE INSTITUTE FOR RURAL HEALTH, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Zachary Smith, Tingjuan Gao, Stephen Lane, Sebastian Wachmann-Hogiu, Denis Dwyre, Laurence Heifetz, James Hood, Dennis Matthews, Keith Tatsukawa
  • Patent number: 10006902
    Abstract: The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on ion channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: June 26, 2018
    Assignee: SOPHION BIOSCIENCE A/S
    Inventors: David Geraint Owen, Nicholas Gerard Byrne
  • Patent number: 9936313
    Abstract: A hearing aid attachment system includes a positioning tool and an interconnection unit. An upper surface of the interconnection unit has a second shape that matches a corresponding first shape of a cavity in the lower surface of the positioning tool so that the upper surface fits into the cavity with a second front surface of the positioning tool against and radially outside the front side of the interconnection unit, with the connection portion of the positioning tool connected to the connecting portion of the interconnection unit. The positioning tool is further configured to be removable from the interconnection unit without removing the interconnection unit from the skin.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: April 3, 2018
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventor: Patrik Westerkull
  • Patent number: 9863931
    Abstract: Embodiments disclosed herein relate to a sensor comprising an on-board control system and a testing system. The on-board system can determine viability of the control system or the testing system. Also disclosed are methods of using such a sensor.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: January 9, 2018
    Assignee: Universal Biosensors Pty Ltd
    Inventors: Peter Michael Newman, Alastair M. Hodges
  • Patent number: 9753003
    Abstract: The present invention relates to diagnostic devices incorporating electrode modules and fluidics for performing chemical analyzes. The invented devices consist of at least one component sensor formed on an electrode module, the sensor being contained within a fluidic housing. The electrode module is a laminate of a perforated epoxy foil and a photo-formed metal foil with sensor membranes deposited into the perforations. The fluidic housing is a diagnostic card consisting of a plastic card-like body, the at least one component sensor, a sealed chamber defined in the card body for containing a fluid, a fluid conduit for fluidically connecting the chamber with the sensor region, a valve for fluidically connecting the chamber to the fluid conduit, and a delivery structure separate and distinct from the valve for forcing fluid from the chamber and into the fluid conduit.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: September 5, 2017
    Assignee: Epocal Inc.
    Inventors: Imants Lauks, Andrzej Maczuszenko
  • Patent number: 9709518
    Abstract: The present invention relates to diagnostic devices incorporating electrode modules and fluidics for performing chemical analyzes. The invented devices consist of at least one component sensor formed on an electrode module, the sensor being contained within a fluidic housing. The electrode module is a laminate of a perforated epoxy foil and a photo-formed metal foil with sensor membranes deposited into the perforations. The fluidic housing is a diagnostic card consisting of a plastic card-like body, the at least one component sensor, a sealed chamber defined in the card body for containing a fluid, a fluid conduit for fluidically connecting the chamber with the sensor region, a valve for fluidically connecting the chamber to the fluid conduit, and a delivery structure separate and distinct from the valve for forcing fluid from the chamber and into the fluid conduit.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: July 18, 2017
    Assignee: Epocal Inc.
    Inventors: Imants Lauks, Andrzej Maczuszenko
  • Patent number: 9658188
    Abstract: An electrochemical test sensor includes a lid and a base. The base has a length and a width. The length of the base is greater than the width of the base. The base includes at least a working electrode, a counter electrode and at least three test-sensor contacts for electrically connecting to a meter. The at least three test-sensor contacts are spaced along the length of the base from each other. The base and the lid assist in forming a fluid chamber for receiving the fluid sample. The electrochemical test sensor further includes a reagent to assist in determining the concentration of the analyte in the fluid sample.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: May 23, 2017
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Greg P. Beer, John P. Creaven
  • Patent number: 9605295
    Abstract: An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical/biochemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10?21 M). In embodiments, the invention provides an ampyometric immuno-sensing system comprising a working electrode, an oxidoreductase, and an external voltage generator, wherein the oxidoreductase is immobilized on the working electrode; and the voltage generator generates a voltage to induce an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by the electrical field, which enhances the quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: March 28, 2017
    Assignee: CLEVELAND STATE UNIVERSITY
    Inventor: Siu-Tung Yau
  • Patent number: 9579651
    Abstract: A biological fluid sample analysis cartridge is provided. The cartridge includes a housing, a fluid module, and an analysis chamber. The fluid module includes a sample acquisition port and an initial channel, and is connected to the housing. The initial channel is sized to draw fluid sample by capillary force, and is in fluid communication with the acquisition port. The initial channel is fixedly positioned relative to the acquisition port such that at least a portion of a fluid sample disposed within the acquisition port will draw into the initial channel. The analysis chamber is connected to the housing, and is in fluid communication with the initial channel.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: February 28, 2017
    Assignee: Abbott Point of Care, Inc.
    Inventors: Vu Phan, John A. Verrant, John Blum, Kaushal K. Verma, Elise G. Edson
  • Patent number: 9498569
    Abstract: In accordance with at least one exemplary embodiment, a syringe device, a method and a system for delivering a therapeutic amount of ozone are disclosed. A sterility case can enclose a syringe portion and can maintain sterility while the syringe device is interfaced to an ozone generator. A valvably-controlled fluid channel can extend from a barrel of the syringe portion through the case. Conducting elements can be attached to the case and can breach the case. The conducting elements can be connected to electrodes. The electrodes can be attached to the syringe portion. The syringe portion can be filled with oxygen gas via the valvably-controlled fluid channel. An electric current can be provided to the conducting elements from the ozone generator resulting in a corona discharge from at least one of the electrodes. A therapeutic amount of ozone gas can be produced from the oxygen gas and the syringe portion delivered into a sterile field without compromise.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: November 22, 2016
    Assignee: Minimus Spine, Inc.
    Inventors: David M. Hooper, Thomas Foster, Noel Henson
  • Patent number: 9291593
    Abstract: An analytical test strip can include a patterned definition layer defining two fluidically-separated sample cells having respective ports, a common electrode arranged over the definition layer and in electrical communication with each of the cells, and respective cell electrodes. Surface portions of each electrode can be exposed. A method for testing a fluid sample using such a strip includes receiving a first fluid sample in the first sample cell and detecting a first electrical property thereof. It is then determined whether a second fluid sample should be added to the other sample cell. An analyte measurement system can include such a strip and test meter to receive the strip. The test meter can detect respective electrical properties of fluid samples in the cells.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: March 22, 2016
    Assignee: Cilag GmbH International
    Inventors: David Elder, Steven Setford, Allan Faulkner, Ryan Walsh
  • Patent number: 9291591
    Abstract: The present disclosure provides a sensor port configured to receive a plurality of analyte sensors having different sizes, shapes and/or electrode configurations. Also provided are analyte meters, analyte monitoring devices and/or systems and drug delivery devices and/or systems utilizing the disclosed sensor ports.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: March 22, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Matthew Simmons, John R. Galasso, Gary Ashley Stafford, Cherie Bulala, Christopher Myles, Philip Justus Wunderle, III, Bonita Song, Richard G. Ries, Morvarid G. Shafie
  • Patent number: 9274098
    Abstract: An analyte meter is configured to digitally test for the presence of a test strip in the meter and for the presence of a sample in the test strip prior to activating an analog current measurement circuit of the meter. A test strip port connector having a plurality of contacts receives an inserted test strip in which the contacts electrically connect to electrodes on the test strip for digitally detecting both the presence of a test strip and a sample added to the test strip. A control circuit monitoring the contacts maintains the analyte meter in a low power mode until detecting both the test strip and the sample, whereupon the control circuit activates the meter and enables an analog analyte measurement circuit.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: March 1, 2016
    Assignee: LifeScan Scotland Limited
    Inventors: David Elder, Stanley Young, Ciaran Carney, Brian Guthrie, Steven Milne, John Young
  • Patent number: 9234865
    Abstract: An analyte test instrument that has a test strip circuitry that can be configured using information provided by a calibration strip to perform assays with test strips having two electrodes and test strips having three electrodes. The analyte test instrument of this invention comprises: (a) a test port for receiving a test strip; (b) a microprocessor for executing instructions downloaded into the analyte test instrument; (c) a test strip circuit capable of having a plurality of configurations, the configurations being set by the microprocessor, whereby an assay can be performed using the test strip.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: January 12, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Yi Wang, Shridhara Alva Karinka, Gurdial Sanghera
  • Patent number: 9207201
    Abstract: The present disclosure provides an orientation-nonspecific sensor port for use in analyte meters designed to detect and quantify analyte levels in a fluid sample along with methods of using the same. The present disclosure also provides compositions and methods for facilitating the correct insertion of a sensor into a corresponding analyte meter.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: December 8, 2015
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Yi Wang, Benjamin J. Feldman, Benjamin M. Rush
  • Patent number: 9184099
    Abstract: A sensing apparatus for sensing target materials including biological or chemical molecules in a fluid. One such apparatus includes a semiconductor-on-insulator (SOI) structure having an electrically-insulating layer, a fluidic channel supported by the SOI structure and configured and arranged to receive and pass a fluid including the target materials, and a semiconductor device including at least three electrically-contiguous semiconductor regions doped to exhibit a common polarity. The semiconductor regions include a sandwiched region sandwiched between two of the other semiconductor regions, and configured and arranged adjacent to the fluidic channel with a surface directed toward the fluidic channel for coupling to the target materials in the fluidic channel, and further arranged for responding to a bias voltage. The sensing apparatus also includes an amplification circuit in or on the SOI and that is arranged to facilitate sensing of the target material near the fluidic channel.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: November 10, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kosar Baghbani-Parizi, Yoshio Nishi, Hesaam Esfandyarpour
  • Patent number: 9128039
    Abstract: This invention discloses a biosensor test strip that comprises a substrate, on which lies a conductive layer that contains a plurality of contact pads, check pads and reaction zones, which contains a plurality of working and reference electrodes, and on which the reaction reagent is deposited. The first contact pad is connected to the working electrode, while the second contact pad is connected to the reference electrode. Furthermore, this invention discloses a biosensor test strip for multiple tests on a single strip. The biosensor test strip includes a substrate with a plurality of incisions to divide the substrate into a plurality of individual test sections.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: September 8, 2015
    Assignee: Joinsoon Medical Technology Co., Ltd.
    Inventor: Jen Fang Lee
  • Patent number: 9101303
    Abstract: The present disclosure provides a contamination resistant sensor port which includes one or more sealing members positioned so as to limit and/or prevent internal contamination of the sensor port with fluids and/or particles present in the environment outside the sensor port.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: August 11, 2015
    Assignee: Abbott Diabetes Care Inc.
    Inventor: John R. Galasso
  • Patent number: 9080967
    Abstract: A chemically sensitive field effect transistor includes a substrate, a conductor track structure situated on the substrate, and a functional layer which is contacted via the conductor track structure. To be able to form a thin, oxidation-stable and temperature-stable conductor track structure, the conductor track structure is made of a metal mixture which includes platinum and one or more metals selected from the group made up of rhodium, iridium, ruthenium, palladium, osmium, gold, scandium, yttrium, lanthanum, the lanthanides, titanium, zirconium, hafnium, niobium, tantalum, chromium, tungsten, rhenium, iron, cobalt, nickel, copper, boron, aluminum, gallium, indium, silicon, and germanium.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: July 14, 2015
    Assignee: ROBERT BOSCH GMBH
    Inventors: Richard Fix, Markus Widenmeyer
  • Patent number: 9079182
    Abstract: An apparatus for performing bioanalytic processing and analysis, a bioanalytical reaction device, and a cartridge thereof are provided. The cartridge contains a housing and at least one sample chamber in a platform for storing biological samples, which the bioanalytical reaction device can process and analyze. The platform is movably connected to the housing such that the platform is movable between a stowed position, in which the sample chamber is protected by the housing, and an extended position, in which the sample chamber is outside of the housing. The bioanalytical reaction device includes an actuation device for moving the platform between the stowed and extended positions.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: July 14, 2015
    Assignee: Biocartis NV
    Inventors: Ronald De Gier, Jozef C. M. Versleegers
  • Publication number: 20150144484
    Abstract: A blood glucose monitor includes a can, a replaceable sensor cartridge that includes a frame, an upper spring disposed between the frame and the can, a case for housing the can and sealing the frame, a lower spring disposed between the can and the case, and a meter housing for sealing an upper portion of the frame. The can is capable of accepting the replaceable sensor cartridge. The frame of the removable cartridge has at least at least two walls defining a chamber for accepting a plurality of biosensors, and a bottom portion defining an opening and at least one sealing flange. The frame can further include a desiccant material capable of reducing humidity within the frame. The frame may be dimensioned such that an interference fit constrains the plurality of biosensors prior to inserting the frame within a blood glucose monitor.
    Type: Application
    Filed: March 13, 2013
    Publication date: May 28, 2015
    Applicant: Bayer HealthCare LLC
    Inventors: Jeffery S. Reynolds, Robert S. Sams, Simin Yao, Eugene Prais, Michael A. Botta, Steven C. Charlton, Mirza Kokic
  • Publication number: 20150144507
    Abstract: A test strip comprising two electrodes having conducting surfaces facing inwardly toward each other in a distal portion of the test strip adjacent a sample chamber. A pair of spacers are disposed, each adjacent one side of the sample chamber, between the electrodes. The electrodes each face in one direction at a proximal end of the test strip so that their conducting surfaces form electrical contacts of the test strip.
    Type: Application
    Filed: November 22, 2013
    Publication date: May 28, 2015
    Applicant: Cilag GmbH International
    Inventor: Russell BAIN
  • Patent number: 9039876
    Abstract: A test strip ejector system for receiving and ejecting a fluid testing medical device test strip includes a mechanism assembly supported by the device whereby user actuation of the mechanism assembly induces displacement of the test strip in at least a test strip ejection direction to eject the test strip. The mechanism assembly includes a power source and an electric motor such as a piezo-electric linear micro motor connected to the power source. The electric motor has an armature displaced when the electric motor is energized. A digital display/user interface is provided. Selection of an ejection function presented on the digital display/user interface initiates operation of the electric motor and displacement of the armature thereby displacing the test strip in the ejection direction. An operating system including a microprocessor is connected to the display/user interface. The microprocessor controls direction of operation and operating speed of the motor.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: May 26, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Clint A. Ecoff, Bryan Rolfs, Anthony J. Uberta, III
  • Publication number: 20150141272
    Abstract: This invention allows ultra-low levels of virtually any biological analyte to be detected and quantified rapidly, simply and inexpensively with an electrochemical biosensor using a novel electrochemical signal amplification technique. The invention amplifies detection signals from low level analytes using an innovative sandwich ELISA structure that replaces optical labels with a massive amount of electrochemically detectable guanine rich oligonucleotide tags. Selective binding is achieved with matched pairs of either commercial or custom analyte binding materials such as monoclonal antibodies or single stand DNA. The guanine tags are eluted from the sandwich structures and hybridize with complementary cytosine rich oligonucleotide recognition probes attached to the surface of a biosensor working electrode. An electrochemical technique generates a signal in proportion to the guanine level on the working electrode which is also proportional to the analyte level in the sample.
    Type: Application
    Filed: February 5, 2014
    Publication date: May 21, 2015
    Inventor: Neil Gordon
  • Publication number: 20150136617
    Abstract: A hematocrit (HCT) measurement system and measurement method using the same are disclosed. The hematocrit (HCT) measurement system comprises a test strip and a measurement apparatus comprising: a connector transmitting an initial signal generated from a blood sample to the measurement apparatus, a capacitive reactance adjustor disposed between the test strip and the measurement apparatus, a calculation unit for calculating concentration and HCT value of the blood sample, an A/D convertor transforming the corresponding initial signal to a digital signal, and a signal processor processing the digital reacted signal and showing measured results on a display, wherein the HCT value is calculated by voltage partition to prevent the signal waveform voltage being saturated or cutoff, thereby resulting in measured signal distortion.
    Type: Application
    Filed: September 15, 2014
    Publication date: May 21, 2015
    Inventors: Chu-Ming Cheng, Lee Teng Yi Wu, Ching-Yuan Chu
  • Patent number: 9034172
    Abstract: An electrochemical test sensor for detecting the concentration of an analyte in a fluid sample. The electrochemical test sensor includes a housing that has a first end and a second opposing end. The housing includes an opening at the first end to receive a fluid test sample. An electrode assembly includes a substrate, a working electrode, a counter electrode and a reagent. The substrate has a first surface and an opposing second surface. The working electrode is disposed on the first surface of the substrate, and the counter electrode is disposed on the second surface of the substrate. The electrode assembly is positioned within the housing to define a reaction channel. The electrochemical test sensor may be used with a removable lancet mechanism or integrated within a lancet mechanism to form one integral unit.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: May 19, 2015
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Yuan Wang, Raeann Gifford, Hualin Jiang, Jeffery S. Reynolds, Jianfeng Fei
  • Patent number: 9034159
    Abstract: Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: May 19, 2015
    Assignee: Luoxis Diagnostics, Inc.
    Inventors: Raphael Bar-Or, David Bar-Or, Leonard T. Rael
  • Patent number: 9032782
    Abstract: Biosensor apparatus and associated method for detecting a target material using a vibrating resonator having a surface that operably interacts with the target material. A detector is in electrical communication with a sensor, the sensor comprising a first paddle assembly connected to a second paddle assembly, the first paddle assembly having at least one microbalance sensing resonator proximate a proximal end and at least one sensing electrical contact proximate a distal end in electrical communication with the sensing resonator. The at least one sensing resonator has a target coating for operably interacting with the target material, and the second paddle assembly has a microbalance reference resonator proximate the proximal end and at least one reference electrical contact proximate the distal end in electrical communication with the reference resonator.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: May 19, 2015
    Assignee: Rapid Diagnostek, Inc.
    Inventors: Richard A. Van Deusen, Ian R. Harmon
  • Publication number: 20150114836
    Abstract: A system for obtaining a pH measurement comprises a disposable probe and a reader. The disposable probe includes at least one indicating electrode and at least one reference electrode. The reader is configured to operably engage with the disposable probe and provide pH information of a sample.
    Type: Application
    Filed: September 6, 2012
    Publication date: April 30, 2015
    Inventors: William Clark, Sung Kwon Cho, Yuejun Zhao, Timothy J. Syciarz, R. Maxwell Flaherty, J. Christopher Flaherty
  • Publication number: 20150096906
    Abstract: A test strip comprising two electrodes having conducting surfaces facing inwardly toward each other in a portion of the test strip adjacent a sample chamber. A pair of spacers are disposed, each adjacent one side of the sample chamber, between the electrodes. The electrodes bypass each other at a proximal end of the test strip away from the sample chamber so that the conducting surfaces face outwardly away from each other to form electrical contact areas of the test strip.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 9, 2015
    Applicant: Cilag GmbH International
    Inventors: Russell BAIN, Scott Sloss
  • Publication number: 20150096888
    Abstract: A blood glucose test device with viewing lens seal includes a meter body rigid portion of a first polymeric material and an opening. A resilient portion of a second polymeric material more compressible than the first polymeric material integrally connected to the rigid portion defines a rigid portion outer covering. A resilient portion edge extends beyond the rigid portion and partially into the opening about a perimeter of the opening. A transparent polymeric material lens has an outer perimeter surface in contact with the resilient portion edge. Multiple flexible arms extending from the lens each have a hook member. Each hook member engages a receiving member positioned in a meter body and is retained by multiple backup ribs. Hook member engagement at a locking position pulls the lens toward the edge partially compressing the second polymeric material and creating a fluid seal between the perimeter surface and edge.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 9, 2015
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Christopher L. Belisle, Craig A. Carson, Robert G. Davies, Joel S. Gerich, Timothy L. Ranney
  • Publication number: 20150094553
    Abstract: In aspects of the present disclosure, a no coding blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that do not require a calibration code is provided. Also disclosed are methods, systems, devices and kits for providing the same.
    Type: Application
    Filed: December 5, 2014
    Publication date: April 2, 2015
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Adam Heller, Benjamin Jay Feldman, Shridhara Alva Karinka, Yi Wang, John R. Galasso
  • Patent number: 8992750
    Abstract: Embodiments of the invention include a test strip with a sample chamber opening spanning the width of the test strip at the sampling end and including a portion of the lateral sides at that end. The chamber is vertically bounded by upper and lower substrate layers, horizontally bounded by the front face of a spacer layer, and open on the remaining sides. The test strip fills rapidly and requires small sample volumes. Both 1-up and 2-up manufacturing techniques for producing such test strips eliminate registration and alignment steps, and other techniques relating to the 2-up technique (simultaneously manufacturing test strips arranged in multiple columns) are also disclosed.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: March 31, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Terry A. Beaty, Eric R. Diebold, Abner D. Joseph, Randall K. Riggles
  • Publication number: 20150083590
    Abstract: A device assembly for measuring and monitoring glucose content of blood, and a cover of such an assembly. The assembly is especially applicable for users with diabetes disease. The assembly includes a resilient cover on a measurement device. The cover has a slit at the input for a blood sample strip. The slit is closed at its rest position, but a test strip can be entered through the slit based on the resilience of the cover material. The resilient cover absorbs possible mechanical impacts and prevents impurities from reaching the sensor electronics.
    Type: Application
    Filed: March 23, 2012
    Publication date: March 26, 2015
    Applicant: Modz Oy
    Inventors: Carina Rajala, Salla Koski, Mikko Tasanen
  • Publication number: 20150076008
    Abstract: A plug side surface of a plug housing is provided with a claw portion. The claw portion includes a plug lock surface facing in a direction away from a connector mounting surface. Each assistant fitting of a receptacle connector includes a receptacle lock surface that faces in a direction approaching the connector mounting surface and is opposed to the plug lock surface in a mated state. The plug lock surface includes a lock maintaining surface and an unlocking surface. Assuming that an angle formed between a reference plane and the lock maintaining surface is a lock maintaining angle and an angle formed between the reference plane and the unlocking surface is an unlocking angle, the lock maintaining angle is smaller than the unlocking angle.
    Type: Application
    Filed: March 28, 2013
    Publication date: March 19, 2015
    Inventors: Panteleimon Athanasiou, Alpesh Patel, David Whitaker, Hua Bai, John Palmer-Felgate, Daniel Coomber-Alford, Jessica Fisher, Chad Schenider, Alex Flamm, Ben Lane, Sam Reed
  • Publication number: 20150076010
    Abstract: An analyte test sensor strip is disclosed having information coded thereon as well as a method of forming the same and conducting an analyte test using the analyte test sensor strip. Information relating to an attribute of the strip or batch/lot of strips may be coded based on resistance values pertaining to electrical aspects of the strip, such as a primary resistive element and a secondary resistive element, the secondary resistive element having one of a plurality of states defined by a location of a closed tap to form a unique resistive path for the secondary resistive element that includes a portion of the primary resistive element depending on the location of the closed tap. The states may be formed on the strip by a secondary processing step in the manufacture of the strip in which a plurality of taps are severed leaving only one tap in a closed state.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 19, 2015
    Inventors: John T. Austera, Terry A. Beaty, Abner D. Joseph, Nathan E. Manlove, Steven K. Moore, James L. Pauley, JR., Randall K. Riggles
  • Patent number: 8980074
    Abstract: A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: March 17, 2015
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventors: Shoji Miyazaki, Hiroyuki Tokunaga, Masaki Fujiwara, Eriko Yamanishi
  • Publication number: 20150068894
    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 12, 2015
    Inventors: Ayub Khattak, Clinton Sever
  • Publication number: 20150068922
    Abstract: Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether at least one output transient signal of the biosensor is erroneous by monitoring the biosensor and flagging an error if the signal outputs of the biosensor do not meet certain criteria.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 12, 2015
    Applicant: LifeScan Scotland Limited
    Inventor: Stephen MACKINTOSH
  • Publication number: 20150072406
    Abstract: Provided is a portable diagnostic test apparatus including: an accommodation portion including an outer side, an inner side, and an accommodation space provided on the inner side; a hinge; and a main body coupled to the accommodation portion by the hinge, where the portable diagnostic test apparatus is configured to be opened and closed by rotating one of the accommodation portion and the main body about the hinge, and where the main body is configured to obtain a result of a measurement based on data collected from drawn blood. The main body and/or the accommodation portion includes at least one strip keeping portion configured to store at least one strip. The at least one strip keeping portion may include: a housing; a discharge portion; and a first movement portion configured to move one of the strips to the discharge portion.
    Type: Application
    Filed: April 3, 2014
    Publication date: March 12, 2015
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: In Duk HWANG, Yeon Moo CHUNG, Na Hui KIM, Jeong Je PARK, Chul Ho YUN
  • Patent number: 8956518
    Abstract: An electrochemical sensing apparatus and methods are provided. In one embodiment, an apparatus is provided having a carrier that supports an electrochemical module and that communicates between electrodes on the electrochemical module and an analyte measurement device.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: February 17, 2015
    Assignee: LifeScan, Inc.
    Inventors: Garry Chambers, Alastair M. Hodges, Ronald C. Chatelier
  • Publication number: 20150027907
    Abstract: Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 29, 2015
    Inventors: Ronald C. Chatelier, Dennis Rylatt, Linda Raineri, Alastair M. Hodges
  • Patent number: RE45764
    Abstract: The present invention relates to technology for constructing a reaction system including a test target, an oxidation-reduction enzyme, and an electron mediator, and measuring the concentration of the test target by an electrochemical process. A Ru compound is used as the electron mediator. The present invention provides a concentration test instrument including a substrate, first and second electrodes formed on the substrate, and a reagent layer formed as a solid. The reagent layer contains an oxidation-reduction enzyme and a Ru compound, and is constituted so as to dissolve and construct a liquid phase reaction system when a sample liquid is supplied.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: October 20, 2015
    Assignee: ARKRAY, Inc.
    Inventors: Kenji Nagakawa, Hideaki Yamaoka