Disposable Apparatus Or Apparatus Having Removable Section (e.g., Removable Cartridge, Etc.) Patents (Class 204/403.02)
  • Patent number: 11307196
    Abstract: Apparatus and methods are described for determining a property of a biological sample. A sample carrier (22) includes one or more sample chambers (40) that define at least a first region (42) and a second region (44), the height of the one or more sample chambers varying between the first and second regions in a predefined manner. A computer processor (28) receives data relating to a first optical measurement that is performed upon a portion of the sample that is disposed within the first region, receives data relating to a second optical measurement that is performed upon a portion of the sample that is disposed within the second region, and determines the property of the sample by using a relationship between the first optical measurement, the second optical measurement, and the predefined variation in height between the regions. Other applications are also described.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: April 19, 2022
    Assignee: S.D. Sight Diagnostics Ltd.
    Inventors: Joseph Joel Pollak, Sarah Levy Schreier, Yochay Shlomo Eshel, Amir Zait, Sharon Pecker, Trevor Ruggiero
  • Patent number: 11235327
    Abstract: A test cartridge for evaluating biological fluids can have a sensor flow cell defining a flow path for selectively passing a test fluid or biological fluid across a sensor to evaluate the sensor or the biological fluid. The test cartridge can include a sample port and at least one deformable reservoir, both formed as part of the test cartridge and fluidly connected to the flow path upstream of the sensor. A biological fluid can be manually fed into the flow path through the sample port for evaluation by the sensor. Before the biological fluid is fed through the sample port, the deformable reservoir can be manually ruptured to pass the test fluid contained within the reservoir across the sensor to first evaluate the sensor. In an example, the deformable reservoir can include a first reservoir containing a liquid quality control (LQC) fluid and a second reservoir containing a calibration fluid.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: February 1, 2022
    Assignee: EasyDx, Inc.
    Inventors: James D. Kurkowski, Thomas P. Brastad, Martin P. Babcock, Michael E. Collison
  • Patent number: 11119065
    Abstract: Provided is an electromagnetic sensor capable of stably measuring electric conductivity and the like even in the case where solid matters are mixed in a sample solution. The electromagnetic sensor includes a substrate, a through hole formed in the substrate, an electrode attached to a surface of the substrate, and a housing that covers the through hole and the electrode, and in this configuration, the sample solution supplied to a surface of the substrate opposite to the surface of the substrate having the electrode attached thereto is allowed to flow into the housing from the through hole and to be accommodated in the housing, so that the sample solution is allowed to be in contact with the electrode.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: September 14, 2021
    Assignee: HORIBA ADVANCED TECHNO, CO., LTD.
    Inventors: Kensuke Toda, Yuichi Ichinari, Manabu Shibata
  • Patent number: 11041871
    Abstract: The present invention describes an integrated incubator and image capture module that regulates the incubator atmosphere and obtains high-resolution digital images of sample specimens. The incubator has a cabinet type enclosure that enables the provision of a controlled environment to the contents of the incubator by having at least three ports on one face of the cabinet for the passage of sample containers. Additionally, an image capture module is located immediately adjacent to the incubator. In this regard, using at least three separate access/egress points for the sample containers streamlines operation of the system and enhances preservation of the incubator environment. Furthermore, locating the image capture module directly adjacent to the incubator reduces the amount of time a sample container is exposed to the external environment, thereby reducing the extent to which samples are exposed to potential contaminants and reducing the exchange of the lab and ambient atmospheres.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: June 22, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Martijn Kleefstra, Martijn Xander Berntsen, Jan Bart Van Der Vijver, Tsjerk Nauta, Andrej Girgenson
  • Patent number: 10969378
    Abstract: The present invention relates to a strip ejection apparatus for a blood glucose meter, wherein: an ejector block moving to eject a measurement strip is received in the space inside a housing, whereby it is possible to make the apparatus compact, thereby enhancing space efficiency of the blood glucose meter; components can be mounted on a PCB of the blood glucose meter in units of modules as they are, without any additional separate assembly for the components, whereby it is possible to enhance efficiency of a manufacturing process; a guide protrusion coupled with an ejection switch of the blood glucose meter is selectively formed on the upper or lower portion of the ejector block or formed on both the upper and lower portions thereof, whereby it is possible to enhance the degree of freedom in design of the mounting position of the ejection switch; and the strip ejection apparatus can be applied to various types of blood glucose meters so that it is possible to standardize the type of strip ejection apparatus,
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: April 6, 2021
    Assignee: I-SENS, INC.
    Inventors: Kyungchul Chae, Hyunho Choi, Goangyel Ryu, Geunsig Cha, Hakhyun Nam
  • Patent number: 10928411
    Abstract: An automated fluid sample collector includes: a collection receptacle; an actuator; and a piercing element coupled to the actuator. An automated sample collection device includes: a sample receptacle; a needle that is able to extend into the sample receptacle; an actuator coupled to the needle such that the actuator is able to extend and retract the needle; and a fluid chip coupled to the sample receptacle, the fluid chip able to accommodate an amount of collected fluid. An automated method of collecting a fluid sample includes: activating a pump associated with a finger retention element in order to add fluid to the finger retention element; extending an actuator associated with a piercing element; opening a pinch valve; activating a collection pump; deactivating the collection pump; closing the pinch valve; and releasing fluid from the finger retention element.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: February 23, 2021
    Assignee: 2Pi-Sigma Corporation
    Inventor: Mehdi Hatamian
  • Patent number: 10914722
    Abstract: A sensor array for simultaneously measuring electrophysiological responses and contractility responses of a tissue includes: a substrate; a multi-electrode array (MEA) disposed in or on the substrate; and a plurality of interdigitized electrodes (IDEs) disposed in or on the substrate. The MEA and the IDEs are interpenetrating within a plane substantially parallel to an upper surface of the substrate. Systems for measuring such responses using the sensor array may also include contacts and/or connectors for interfacing with external control devices, electrodes, and cell culture components such as a chamber and lid. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: February 9, 2021
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Fang Qian, Chao Huang, Anna Nikolaevna Ivanovskaya, Kris Kulp, Elizabeth K. Wheeler
  • Patent number: 10888283
    Abstract: A COVID-19 Symptoms Alert Machine (CSAM) scanner, or apparatus, is described herein. This apparatus employs Artificial Intelligent (AI) technology in combination with the latest mobile device technology (viz. smart phone/smart watch) to quickly help track down people who have COVID-19 symptoms anywhere and anytime, isolate them, and professionally handle them, not allowing SARS-CoV-2 virus to spread. CSAM automatically measures body temperature and assesses lung conditions such as pulmonary fibrosis and B-lines (for asymptomatic people), and other current health vital information (CHVI), furnished by the participant, such as fever, sore throat, headache, and body ache to generate an alert signal when COVID-19 symptoms are found significant and to send it out to a COVID-19 control center. The alerted participant is then immediately required to go to the COVID-19 control center or be picked up by a special COVID-19 emergency vehicle for isolation and further evaluation and testing.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: January 12, 2021
    Inventors: Boonsieng Benjauthrit, Sorapod B. Benjauthrit, Vatcharee L. Benjauthrit, Kamolchanok J. Benjauthrit
  • Patent number: 10859545
    Abstract: A system for providing standard mixtures of volatile and semi-volatile organic compounds for simultaneous GC and MS calibration in a calibration vial, wherein calibration mixtures are prepared by diluting calibration analytes in granular PDMS such that most of the analytes are in the PDMS phase and the sample can then be taken from the analytes in the headspace vapor in the calibration vial, wherein a reliable calibration sample can be taken from the calibration vial because the analytes in the PDMS phase and the headspace vapor are in thermodynamic equilibrium, and wherein the method provides solvent-less sampling, long-time stability, ease of use, is quantifiable, and related to temperature.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: December 8, 2020
    Assignee: BRIGHAM YOUNG UNIVERSITY
    Inventors: Milton L. Lee, Xiaofeng Xie, Jacolin A. Murray, Jesse A. Contreras, Tai Van Truong, H. Dennis Tolley
  • Patent number: 10828400
    Abstract: A substrate subject to degradation at temperatures above 100° C. is coated with a nanostructured ceramic coating having a thickness in excess of 100 nm, formed on a surface of the substrate, wherein a process temperature for deposition of the nanostructured coating does not exceed 90° C. The coating may be photocatalytic, photovoltaic, or piezoelectric. The coating, when moistened and exposed to ultraviolet light or sunlight, advantageously generates free radicals, which may be biocidal, deodorizing, or assist in degradation of surface deposits on the substrate after use. The substrate may be biological or organic, and may have a metallic or conductive intermediate layer.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: November 10, 2020
    Assignee: The Research Foundation for the State University of New York
    Inventor: Junghyun Cho
  • Patent number: 10758846
    Abstract: A microfluidic device includes a first layer of a porous material with pores having a first average pore size and a liquid-receiving area through which a liquid sample is received into the microfluidic device. A second layer of another porous material, with pores of a second average pore size, is stacked below the first layer and has a channel with a starting end positioned at least in part in an overlapping manner with the liquid-receiving area. The channel has a terminating end extending laterally at a predetermined wicking distance from the starting end. The first average pore size and the second average pore size cause a wicking effect in which at least some of the liquid sample flows along the channel at least a portion of the wicking distance between the starting end and the terminating end.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: September 1, 2020
    Assignee: Trustees of Tufts College
    Inventors: Charles R. Mace, Syrena C. Fernandes, Samuel B. Berry
  • Patent number: 10739296
    Abstract: Disclosed is a biological analyte monitoring device including a strip inserter in which a test strip is to be inserted, and a processor configured to read a code sequence based on an element detected from an index region, a first code region, and a second code region of the test strip in response to the test strip being inserted in the strip inserter, wherein the processor is further configured to determine a target interval in which an index element formed in the index region is detected while the test strip is being inserted in the strip inserter, detect a first code element formed in the first code region in the target interval and detect a second code element formed in the second code region in the target interval, and identify the code sequence based on a result of detecting the first code element and the second code element.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: August 11, 2020
    Assignee: PHILOSYS CO., LTD.
    Inventor: In Hwan Choi
  • Patent number: 10595759
    Abstract: Methods, systems, and devices are disclosed mouth-based biosensors and biofuel cells. In one aspect, an electrochemical sensor device for detecting analytes in saliva includes a substrate including an electrically insulative material, a first electrode disposed on the substrate at a first location, in which the first electrode includes a surface including a chemical agent (e.g., a catalyst or a reactant) corresponding to an analyte in saliva; and a second electrode disposed on the substrate at a second location separated from the first electrode by a spacing region, the first and second electrodes capable of sustaining a redox reaction involving the chemical agent and the analyte to produce an electrical signal, such that, when the device is present in the mouth of a user and electrically coupled to an electrical circuit, the device is operable to detect the analyte in the user's saliva.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: March 24, 2020
    Assignee: The Regents of the University of California
    Inventors: Joseph Wang, Patrick Mercier
  • Patent number: 10527575
    Abstract: An auto-calibration system for diagnostic test strips is described for presenting data individually carried on each test strip readable by a diagnostic meter. The test strip meter may provide a predetermined varying resistance on one strip or a plurality of varying resistances from strip lot to strip lot.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: January 7, 2020
    Assignee: Trividia Health, Inc.
    Inventors: Gary T. Neel, Brent E. Modzelewski, Allan Javier Caban, Adam Mark Will, Carlos Oti
  • Patent number: 10428375
    Abstract: A nucleic acid amplification and detection apparatus, including: a support configured to receive a plurality of reaction vessels containing respective samples of one or more nucleic acids to be amplified, the support being rotatable about an axis of rotation and the reaction vessels being received in the support at respective receiving locations distributed about the axis of rotation; a temperature control component thermally coupled to the support and configured to control the temperature of the support in order to amplify the nucleic acids contained in the reaction vessels while received in the support; one or more measurement components configured to measure one or more characteristics of the nucleic acids within the reaction vessels at respective measurement locations distributed about the axis of rotation; an actuator coupled to the support and configured to rotate the support about the axis of rotation; and a sample position controller coupled to the actuator and being configured to rotate the support a
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: October 1, 2019
    Assignee: AXXIN PTY LTD
    Inventor: William Robb Hopper
  • Patent number: 10386351
    Abstract: Methods and sensors for detection and quantification of one or more analyte in a test sample are described. A response profile of a gas sensor to a control sample of a known interrogator gas is determined. The gas sensor is exposed to a test sample then to a second sample comprising the known interrogator gas, and a test sample response profile of the gas sensor is determined. One or more test sample sensor response profiles are compared with one or more control sensor response profiles for detecting, identifying, and quantifying one or more analytes in the test sample.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: August 20, 2019
    Assignee: NANOHMICS, INC.
    Inventors: Steve M. Savoy, Kyle W. Hoover, Daniel R. Mitchell, Jeremy J. John, Chris W. Mann, Alexander P. Greis
  • Patent number: 10364452
    Abstract: Methods, systems, and devices are disclosed for providing test strip electrochemical sensors for rapid quantitative analysis of analytes in physiological fluids. In one aspect, an electrochemical sensor includes a substrate; an electrode contingent including a first electrode having a coating of carbon nanotubes (CNTs) and a second electrode on the substrate; and an entrapment layer formed on the first electrode to attach an enzymatic substance capable of causing a redox reaction in the presence of a target analyte of a fluid sample which produces a redox-active product, in which the entrapment layer is structured to include a conductive polymer film that is reversibly dopable to conduct charge carriers across the entrapment layer and at the first electrode. For example, the electrochemical sensor can be provided on a disposable test strip to quantify L-DOPA levels in whole blood, plasma, or serum samples.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: July 30, 2019
    Assignees: The Regents of the University of California, Biolinq Incorporated
    Inventors: Joseph Wang, Irene Litvan, Joshua Ray Windmiller
  • Patent number: 10209243
    Abstract: Disclosed is a device (100) for cardiac electrophysiology screening comprising a substrate (10) comprising a cavity (42), said substrate carrying a deformable layer (32) extending over said cavity (42), wherein a portion of said deformable layer (32) covers said cavity and acts as a membrane over said cavity (32), said portion having a surface comprising a pattern of grooves (44) and carrying a multi-electrode structure (110, 110?); and a plurality of cardiomyocytes (130) assembled in at least some of said grooves (44). A method of manufacturing such a device (100) is also disclosed.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: February 19, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Ronald Dekker, Anja Van De Stolpe, Berent Jan Van Meer, Saeed Khoshefetrat Pakazad, Angel Savov
  • Patent number: 10156540
    Abstract: A test strip for biological component measurement includes a substrate. A pair of a working electrode and a counter electrode, a sensor unit that produces an electrochemical reaction with a bodily fluid of a measurement subject and produces a change in electrical characteristics, a resistance portion having an electrical resistance expressing attribute information including a sensitivity of the test strip, and a pair of wires connected to both ends of the resistance portion are provided on the substrate. The resistance portion has a plurality of narrow patterns, each having a resistivity and provided so as to be distanced from each other. An end portion of each narrow pattern is near another narrow pattern. A substantially circular pattern is provided to overlap locations where the end portions of the narrow patterns are near each other, enabling the end portions to conduct with each other.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: December 18, 2018
    Assignee: OMRON HEALTHCARE CO., LTD.
    Inventors: Kenichiro Zaitsu, Muneo Tokita, Satoshi Nakajima
  • Patent number: 10067082
    Abstract: A biosensor (102) for determining the presence or amount of a substance in a sample and methods of use of the biosensor (102) are provided. The biosensor (102) for receiving a user sample to be analyzed includes a mixture for electrochemical reaction with an analyte. The mixture includes an enzyme, a mediator and an oxidizable species as an internal reference.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: September 4, 2018
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Greg P. Beer, Huan-Ping Wu, Kin-Fai Yip
  • Patent number: 10042006
    Abstract: A number of illustrative variations may include a method of estimating battery health including using a charging resistance equivalent.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: August 7, 2018
    Assignee: GM Global Technology Operations LLC
    Inventors: Xinyu Du, Yilu Zhang, Mark J. Rychlinski
  • Patent number: 10024858
    Abstract: This disclosure describes the development of a sample preparation, measurement, and analysis method that permits accurate characterization of red blood cells, platelets, and white blood cells, including a 3-part differential of the white blood cells count, to be performed on small volumes of a biological sample. This method is compatible with compact and portable instrumentation that permits the sample collection to be performed in a subject's home and analysis to be performed elsewhere by transmission of the data to a laboratory or doctor's office.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: July 17, 2018
    Assignees: TAHOE INSTITUTE FOR RURAL HEALTH, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Zachary Smith, Tingjuan Gao, Stephen Lane, Sebastian Wachmann-Hogiu, Denis Dwyre, Laurence Heifetz, James Hood, Dennis Matthews, Keith Tatsukawa
  • Patent number: 10006902
    Abstract: The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on ion channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: June 26, 2018
    Assignee: SOPHION BIOSCIENCE A/S
    Inventors: David Geraint Owen, Nicholas Gerard Byrne
  • Patent number: 9936313
    Abstract: A hearing aid attachment system includes a positioning tool and an interconnection unit. An upper surface of the interconnection unit has a second shape that matches a corresponding first shape of a cavity in the lower surface of the positioning tool so that the upper surface fits into the cavity with a second front surface of the positioning tool against and radially outside the front side of the interconnection unit, with the connection portion of the positioning tool connected to the connecting portion of the interconnection unit. The positioning tool is further configured to be removable from the interconnection unit without removing the interconnection unit from the skin.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: April 3, 2018
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventor: Patrik Westerkull
  • Patent number: 9863931
    Abstract: Embodiments disclosed herein relate to a sensor comprising an on-board control system and a testing system. The on-board system can determine viability of the control system or the testing system. Also disclosed are methods of using such a sensor.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: January 9, 2018
    Assignee: Universal Biosensors Pty Ltd
    Inventors: Peter Michael Newman, Alastair M. Hodges
  • Patent number: 9753003
    Abstract: The present invention relates to diagnostic devices incorporating electrode modules and fluidics for performing chemical analyzes. The invented devices consist of at least one component sensor formed on an electrode module, the sensor being contained within a fluidic housing. The electrode module is a laminate of a perforated epoxy foil and a photo-formed metal foil with sensor membranes deposited into the perforations. The fluidic housing is a diagnostic card consisting of a plastic card-like body, the at least one component sensor, a sealed chamber defined in the card body for containing a fluid, a fluid conduit for fluidically connecting the chamber with the sensor region, a valve for fluidically connecting the chamber to the fluid conduit, and a delivery structure separate and distinct from the valve for forcing fluid from the chamber and into the fluid conduit.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: September 5, 2017
    Assignee: Epocal Inc.
    Inventors: Imants Lauks, Andrzej Maczuszenko
  • Patent number: 9709518
    Abstract: The present invention relates to diagnostic devices incorporating electrode modules and fluidics for performing chemical analyzes. The invented devices consist of at least one component sensor formed on an electrode module, the sensor being contained within a fluidic housing. The electrode module is a laminate of a perforated epoxy foil and a photo-formed metal foil with sensor membranes deposited into the perforations. The fluidic housing is a diagnostic card consisting of a plastic card-like body, the at least one component sensor, a sealed chamber defined in the card body for containing a fluid, a fluid conduit for fluidically connecting the chamber with the sensor region, a valve for fluidically connecting the chamber to the fluid conduit, and a delivery structure separate and distinct from the valve for forcing fluid from the chamber and into the fluid conduit.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: July 18, 2017
    Assignee: Epocal Inc.
    Inventors: Imants Lauks, Andrzej Maczuszenko
  • Patent number: 9658188
    Abstract: An electrochemical test sensor includes a lid and a base. The base has a length and a width. The length of the base is greater than the width of the base. The base includes at least a working electrode, a counter electrode and at least three test-sensor contacts for electrically connecting to a meter. The at least three test-sensor contacts are spaced along the length of the base from each other. The base and the lid assist in forming a fluid chamber for receiving the fluid sample. The electrochemical test sensor further includes a reagent to assist in determining the concentration of the analyte in the fluid sample.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: May 23, 2017
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Greg P. Beer, John P. Creaven
  • Patent number: 9605295
    Abstract: An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical/biochemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10?21 M). In embodiments, the invention provides an ampyometric immuno-sensing system comprising a working electrode, an oxidoreductase, and an external voltage generator, wherein the oxidoreductase is immobilized on the working electrode; and the voltage generator generates a voltage to induce an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by the electrical field, which enhances the quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: March 28, 2017
    Assignee: CLEVELAND STATE UNIVERSITY
    Inventor: Siu-Tung Yau
  • Patent number: 9579651
    Abstract: A biological fluid sample analysis cartridge is provided. The cartridge includes a housing, a fluid module, and an analysis chamber. The fluid module includes a sample acquisition port and an initial channel, and is connected to the housing. The initial channel is sized to draw fluid sample by capillary force, and is in fluid communication with the acquisition port. The initial channel is fixedly positioned relative to the acquisition port such that at least a portion of a fluid sample disposed within the acquisition port will draw into the initial channel. The analysis chamber is connected to the housing, and is in fluid communication with the initial channel.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: February 28, 2017
    Assignee: Abbott Point of Care, Inc.
    Inventors: Vu Phan, John A. Verrant, John Blum, Kaushal K. Verma, Elise G. Edson
  • Patent number: 9498569
    Abstract: In accordance with at least one exemplary embodiment, a syringe device, a method and a system for delivering a therapeutic amount of ozone are disclosed. A sterility case can enclose a syringe portion and can maintain sterility while the syringe device is interfaced to an ozone generator. A valvably-controlled fluid channel can extend from a barrel of the syringe portion through the case. Conducting elements can be attached to the case and can breach the case. The conducting elements can be connected to electrodes. The electrodes can be attached to the syringe portion. The syringe portion can be filled with oxygen gas via the valvably-controlled fluid channel. An electric current can be provided to the conducting elements from the ozone generator resulting in a corona discharge from at least one of the electrodes. A therapeutic amount of ozone gas can be produced from the oxygen gas and the syringe portion delivered into a sterile field without compromise.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: November 22, 2016
    Assignee: Minimus Spine, Inc.
    Inventors: David M. Hooper, Thomas Foster, Noel Henson
  • Patent number: 9291593
    Abstract: An analytical test strip can include a patterned definition layer defining two fluidically-separated sample cells having respective ports, a common electrode arranged over the definition layer and in electrical communication with each of the cells, and respective cell electrodes. Surface portions of each electrode can be exposed. A method for testing a fluid sample using such a strip includes receiving a first fluid sample in the first sample cell and detecting a first electrical property thereof. It is then determined whether a second fluid sample should be added to the other sample cell. An analyte measurement system can include such a strip and test meter to receive the strip. The test meter can detect respective electrical properties of fluid samples in the cells.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: March 22, 2016
    Assignee: Cilag GmbH International
    Inventors: David Elder, Steven Setford, Allan Faulkner, Ryan Walsh
  • Patent number: 9291591
    Abstract: The present disclosure provides a sensor port configured to receive a plurality of analyte sensors having different sizes, shapes and/or electrode configurations. Also provided are analyte meters, analyte monitoring devices and/or systems and drug delivery devices and/or systems utilizing the disclosed sensor ports.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: March 22, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Matthew Simmons, John R. Galasso, Gary Ashley Stafford, Cherie Bulala, Christopher Myles, Philip Justus Wunderle, III, Bonita Song, Richard G. Ries, Morvarid G. Shafie
  • Patent number: 9274098
    Abstract: An analyte meter is configured to digitally test for the presence of a test strip in the meter and for the presence of a sample in the test strip prior to activating an analog current measurement circuit of the meter. A test strip port connector having a plurality of contacts receives an inserted test strip in which the contacts electrically connect to electrodes on the test strip for digitally detecting both the presence of a test strip and a sample added to the test strip. A control circuit monitoring the contacts maintains the analyte meter in a low power mode until detecting both the test strip and the sample, whereupon the control circuit activates the meter and enables an analog analyte measurement circuit.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: March 1, 2016
    Assignee: LifeScan Scotland Limited
    Inventors: David Elder, Stanley Young, Ciaran Carney, Brian Guthrie, Steven Milne, John Young
  • Patent number: 9234865
    Abstract: An analyte test instrument that has a test strip circuitry that can be configured using information provided by a calibration strip to perform assays with test strips having two electrodes and test strips having three electrodes. The analyte test instrument of this invention comprises: (a) a test port for receiving a test strip; (b) a microprocessor for executing instructions downloaded into the analyte test instrument; (c) a test strip circuit capable of having a plurality of configurations, the configurations being set by the microprocessor, whereby an assay can be performed using the test strip.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: January 12, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Yi Wang, Shridhara Alva Karinka, Gurdial Sanghera
  • Patent number: 9207201
    Abstract: The present disclosure provides an orientation-nonspecific sensor port for use in analyte meters designed to detect and quantify analyte levels in a fluid sample along with methods of using the same. The present disclosure also provides compositions and methods for facilitating the correct insertion of a sensor into a corresponding analyte meter.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: December 8, 2015
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Yi Wang, Benjamin J. Feldman, Benjamin M. Rush
  • Patent number: 9184099
    Abstract: A sensing apparatus for sensing target materials including biological or chemical molecules in a fluid. One such apparatus includes a semiconductor-on-insulator (SOI) structure having an electrically-insulating layer, a fluidic channel supported by the SOI structure and configured and arranged to receive and pass a fluid including the target materials, and a semiconductor device including at least three electrically-contiguous semiconductor regions doped to exhibit a common polarity. The semiconductor regions include a sandwiched region sandwiched between two of the other semiconductor regions, and configured and arranged adjacent to the fluidic channel with a surface directed toward the fluidic channel for coupling to the target materials in the fluidic channel, and further arranged for responding to a bias voltage. The sensing apparatus also includes an amplification circuit in or on the SOI and that is arranged to facilitate sensing of the target material near the fluidic channel.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: November 10, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kosar Baghbani-Parizi, Yoshio Nishi, Hesaam Esfandyarpour
  • Patent number: 9128039
    Abstract: This invention discloses a biosensor test strip that comprises a substrate, on which lies a conductive layer that contains a plurality of contact pads, check pads and reaction zones, which contains a plurality of working and reference electrodes, and on which the reaction reagent is deposited. The first contact pad is connected to the working electrode, while the second contact pad is connected to the reference electrode. Furthermore, this invention discloses a biosensor test strip for multiple tests on a single strip. The biosensor test strip includes a substrate with a plurality of incisions to divide the substrate into a plurality of individual test sections.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: September 8, 2015
    Assignee: Joinsoon Medical Technology Co., Ltd.
    Inventor: Jen Fang Lee
  • Patent number: 9101303
    Abstract: The present disclosure provides a contamination resistant sensor port which includes one or more sealing members positioned so as to limit and/or prevent internal contamination of the sensor port with fluids and/or particles present in the environment outside the sensor port.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: August 11, 2015
    Assignee: Abbott Diabetes Care Inc.
    Inventor: John R. Galasso
  • Patent number: 9079182
    Abstract: An apparatus for performing bioanalytic processing and analysis, a bioanalytical reaction device, and a cartridge thereof are provided. The cartridge contains a housing and at least one sample chamber in a platform for storing biological samples, which the bioanalytical reaction device can process and analyze. The platform is movably connected to the housing such that the platform is movable between a stowed position, in which the sample chamber is protected by the housing, and an extended position, in which the sample chamber is outside of the housing. The bioanalytical reaction device includes an actuation device for moving the platform between the stowed and extended positions.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: July 14, 2015
    Assignee: Biocartis NV
    Inventors: Ronald De Gier, Jozef C. M. Versleegers
  • Patent number: 9080967
    Abstract: A chemically sensitive field effect transistor includes a substrate, a conductor track structure situated on the substrate, and a functional layer which is contacted via the conductor track structure. To be able to form a thin, oxidation-stable and temperature-stable conductor track structure, the conductor track structure is made of a metal mixture which includes platinum and one or more metals selected from the group made up of rhodium, iridium, ruthenium, palladium, osmium, gold, scandium, yttrium, lanthanum, the lanthanides, titanium, zirconium, hafnium, niobium, tantalum, chromium, tungsten, rhenium, iron, cobalt, nickel, copper, boron, aluminum, gallium, indium, silicon, and germanium.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: July 14, 2015
    Assignee: ROBERT BOSCH GMBH
    Inventors: Richard Fix, Markus Widenmeyer
  • Publication number: 20150144507
    Abstract: A test strip comprising two electrodes having conducting surfaces facing inwardly toward each other in a distal portion of the test strip adjacent a sample chamber. A pair of spacers are disposed, each adjacent one side of the sample chamber, between the electrodes. The electrodes each face in one direction at a proximal end of the test strip so that their conducting surfaces form electrical contacts of the test strip.
    Type: Application
    Filed: November 22, 2013
    Publication date: May 28, 2015
    Applicant: Cilag GmbH International
    Inventor: Russell BAIN
  • Publication number: 20150144484
    Abstract: A blood glucose monitor includes a can, a replaceable sensor cartridge that includes a frame, an upper spring disposed between the frame and the can, a case for housing the can and sealing the frame, a lower spring disposed between the can and the case, and a meter housing for sealing an upper portion of the frame. The can is capable of accepting the replaceable sensor cartridge. The frame of the removable cartridge has at least at least two walls defining a chamber for accepting a plurality of biosensors, and a bottom portion defining an opening and at least one sealing flange. The frame can further include a desiccant material capable of reducing humidity within the frame. The frame may be dimensioned such that an interference fit constrains the plurality of biosensors prior to inserting the frame within a blood glucose monitor.
    Type: Application
    Filed: March 13, 2013
    Publication date: May 28, 2015
    Applicant: Bayer HealthCare LLC
    Inventors: Jeffery S. Reynolds, Robert S. Sams, Simin Yao, Eugene Prais, Michael A. Botta, Steven C. Charlton, Mirza Kokic
  • Patent number: 9039876
    Abstract: A test strip ejector system for receiving and ejecting a fluid testing medical device test strip includes a mechanism assembly supported by the device whereby user actuation of the mechanism assembly induces displacement of the test strip in at least a test strip ejection direction to eject the test strip. The mechanism assembly includes a power source and an electric motor such as a piezo-electric linear micro motor connected to the power source. The electric motor has an armature displaced when the electric motor is energized. A digital display/user interface is provided. Selection of an ejection function presented on the digital display/user interface initiates operation of the electric motor and displacement of the armature thereby displacing the test strip in the ejection direction. An operating system including a microprocessor is connected to the display/user interface. The microprocessor controls direction of operation and operating speed of the motor.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: May 26, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Clint A. Ecoff, Bryan Rolfs, Anthony J. Uberta, III
  • Publication number: 20150136617
    Abstract: A hematocrit (HCT) measurement system and measurement method using the same are disclosed. The hematocrit (HCT) measurement system comprises a test strip and a measurement apparatus comprising: a connector transmitting an initial signal generated from a blood sample to the measurement apparatus, a capacitive reactance adjustor disposed between the test strip and the measurement apparatus, a calculation unit for calculating concentration and HCT value of the blood sample, an A/D convertor transforming the corresponding initial signal to a digital signal, and a signal processor processing the digital reacted signal and showing measured results on a display, wherein the HCT value is calculated by voltage partition to prevent the signal waveform voltage being saturated or cutoff, thereby resulting in measured signal distortion.
    Type: Application
    Filed: September 15, 2014
    Publication date: May 21, 2015
    Inventors: Chu-Ming Cheng, Lee Teng Yi Wu, Ching-Yuan Chu
  • Publication number: 20150141272
    Abstract: This invention allows ultra-low levels of virtually any biological analyte to be detected and quantified rapidly, simply and inexpensively with an electrochemical biosensor using a novel electrochemical signal amplification technique. The invention amplifies detection signals from low level analytes using an innovative sandwich ELISA structure that replaces optical labels with a massive amount of electrochemically detectable guanine rich oligonucleotide tags. Selective binding is achieved with matched pairs of either commercial or custom analyte binding materials such as monoclonal antibodies or single stand DNA. The guanine tags are eluted from the sandwich structures and hybridize with complementary cytosine rich oligonucleotide recognition probes attached to the surface of a biosensor working electrode. An electrochemical technique generates a signal in proportion to the guanine level on the working electrode which is also proportional to the analyte level in the sample.
    Type: Application
    Filed: February 5, 2014
    Publication date: May 21, 2015
    Inventor: Neil Gordon
  • Patent number: 9034159
    Abstract: Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: May 19, 2015
    Assignee: Luoxis Diagnostics, Inc.
    Inventors: Raphael Bar-Or, David Bar-Or, Leonard T. Rael
  • Patent number: 9034172
    Abstract: An electrochemical test sensor for detecting the concentration of an analyte in a fluid sample. The electrochemical test sensor includes a housing that has a first end and a second opposing end. The housing includes an opening at the first end to receive a fluid test sample. An electrode assembly includes a substrate, a working electrode, a counter electrode and a reagent. The substrate has a first surface and an opposing second surface. The working electrode is disposed on the first surface of the substrate, and the counter electrode is disposed on the second surface of the substrate. The electrode assembly is positioned within the housing to define a reaction channel. The electrochemical test sensor may be used with a removable lancet mechanism or integrated within a lancet mechanism to form one integral unit.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: May 19, 2015
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Yuan Wang, Raeann Gifford, Hualin Jiang, Jeffery S. Reynolds, Jianfeng Fei
  • Patent number: 9032782
    Abstract: Biosensor apparatus and associated method for detecting a target material using a vibrating resonator having a surface that operably interacts with the target material. A detector is in electrical communication with a sensor, the sensor comprising a first paddle assembly connected to a second paddle assembly, the first paddle assembly having at least one microbalance sensing resonator proximate a proximal end and at least one sensing electrical contact proximate a distal end in electrical communication with the sensing resonator. The at least one sensing resonator has a target coating for operably interacting with the target material, and the second paddle assembly has a microbalance reference resonator proximate the proximal end and at least one reference electrical contact proximate the distal end in electrical communication with the reference resonator.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: May 19, 2015
    Assignee: Rapid Diagnostek, Inc.
    Inventors: Richard A. Van Deusen, Ian R. Harmon
  • Patent number: RE45764
    Abstract: The present invention relates to technology for constructing a reaction system including a test target, an oxidation-reduction enzyme, and an electron mediator, and measuring the concentration of the test target by an electrochemical process. A Ru compound is used as the electron mediator. The present invention provides a concentration test instrument including a substrate, first and second electrodes formed on the substrate, and a reagent layer formed as a solid. The reagent layer contains an oxidation-reduction enzyme and a Ru compound, and is constituted so as to dissolve and construct a liquid phase reaction system when a sample liquid is supplied.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: October 20, 2015
    Assignee: ARKRAY, Inc.
    Inventors: Kenji Nagakawa, Hideaki Yamaoka