Enzyme Included In Apparatus Patents (Class 204/403.14)
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Publication number: 20120073969Abstract: The invention is directed to methods and devices for reducing interference from heterophile antibodies in an analyte immunoassay. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with non-human IgM or fragments thereof by dissolving into said sample a dry reagent to yield a non-human IgM concentration of at least about 20 ?g/mL or equivalent fragment concentration; and (b) performing an electrochemical immunoassay on the amended sample to determine the concentration of said analyte in said sample. Preferably, the sample is amended with IgG or fragments thereof in addition to the IgM of fragments thereof.Type: ApplicationFiled: December 6, 2011Publication date: March 29, 2012Applicant: ABBOTT POINT OF CARE INC.Inventors: John Lewis Emerson Campbell, John Emegbero Omakor
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Publication number: 20120067734Abstract: Embodiments herein provide a membrane that is a product of a phenol crosslinked with one or more compounds containing an allyl group. The phenol may be electropolymerized with the allyl-containing compounds to form the crosslinked polymer. Suitable allyl-containing compounds include allylphenol, allylalcohol, allylamine, and allylcarbamide. A membrane may have one type of allyl-containing compound, or, alternatively, two or more types of compounds. As used in an analyte sensing device, a membrane formed from a crosslinked phenol may provide improved interference exclusion, peroxide response, stability, and/or solvent resistance.Type: ApplicationFiled: May 13, 2011Publication date: March 22, 2012Applicant: BAYER HEALTHCARE LLCInventors: Yuan Wang, Raeanne Gifford
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Publication number: 20120067742Abstract: The present invention provides a linker for joining an electrode and a capture probe on a biochip, and a biochip comprising the linker. The impedance baseline of the linker of the present invention is three orders lower than the conventional long chain thiol linker when adopting in a fadaraic impedance biochip construction. With lower impedance baseline, the device designed to measure the signal of the biochip of the present invention could be further simplied on the electrical circuit design and be made in lower cost, compacter size and get the potential to be used in point-of-care applications. The present invention also provides a method of quantitatively detecting a concentration of a target analyte in a fluid sample by adopting the biochip and the linker of present invention.Type: ApplicationFiled: June 16, 2011Publication date: March 22, 2012Applicant: NATIONAL TAIWAN UNIVERSITYInventors: Chih-Kung Lee, Adam Shih-Yuan Lee, Ching-Sung Chen, Ku-Ning Chang, Ying-Hua Chen, Bryan Yong-Jay Lee
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Publication number: 20120061259Abstract: A biosensor for quantifying an analyte in a sample and usage thereof are provided. The biosensor includes an insulative substrate, a cover, a sample supply port, an electrode system including at least a working electrode, a counter electrode and a third electrode, and a reaction layer at least formed over the working electrode. The third electrode, used for estimating whether the amount of the sample is sufficient, is disposed nearer to the sample supply port than the counter electrode is. Whether the amount of the added sample is sufficient is estimated by comparing the electrical current value detected between the working electrode and the counter electrode with the electrical current value detected between the working electrode and the third electrode. This invention has a simple structure and produces accurate measurements.Type: ApplicationFiled: May 24, 2010Publication date: March 15, 2012Applicant: LEADWAY (HK) LIMITEDInventors: Jinn-Nan Lin, Chia-Lin Wang, Ziyi Zhang
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Publication number: 20120055812Abstract: A biosensor comprises a space part for sucking and housing a sample formed of two upper and lower plates, the two plates being stuck together by an adhesive layer, the space part for sucking and housing the sample being constituted so as to be partially opened in the peripheral part and partially closed by the adhesive layer, and has a working electrode having at least glucose oxidase immobilized thereon and a counter electrode on the same plane of the plate.Type: ApplicationFiled: September 6, 2011Publication date: March 8, 2012Inventors: Masao Gotoh, Hiroki Mure, Hiroshi Shirakawa
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Patent number: 8128802Abstract: Disclosed is a method for calculating a ratio of glycosylated hemoglobin with high accuracy by electrochemically detecting the concentration of fructosyl valine or fructosyl valyl-histidine in a sample. Also disclosed is an apparatus for assaying glucose and glycosylated hemoglobin simultaneously. Further disclosed are a method and an apparatus for removing hydrogen peroxide in a sample.Type: GrantFiled: May 2, 2006Date of Patent: March 6, 2012Assignees: OJI Paper Co., Ltd, OJI Scientific Instruments Co., LtdInventors: Yoko Nanjo, Ryuzo Hayashi
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Patent number: 8128803Abstract: A method follow the change in concentration of a redox-active substance, whereby suitable potentials for a reduction process or an oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of measuring phase and relaxation phase being determined in a suitable manner. A rapid relaxation of the concentration gradient is electrochemically forced so that the measurement can be carried out on simple transducer arrays. A device for carrying out the method includes a transducer array in addition to a suitable potentiostat. The transducer array can be formed of a planar metal substrate on which at least one flexible insulator is disposed, the metal surface and the insulator surface being firmly linked. The transducer array can also be formed of silicone-based CMOS structures.Type: GrantFiled: July 31, 2006Date of Patent: March 6, 2012Assignee: Siemens AktiengesellschaftInventors: Heike Barlag, Walter Gumbrecht, Konrad Mund
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Patent number: 8123920Abstract: The presence of a select analyte in the sample is evaluated in an electrochemical system using a conduction cell-type apparatus. A potential or current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes After the gradient is established, the applied potential or current is discontinued and an analyte-independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte-dependent signal obtained during application of the potential or current.Type: GrantFiled: March 5, 2009Date of Patent: February 28, 2012Assignee: Agamatrix, Inc.Inventors: Sridhar G. Iyengar, Ian Harding
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Publication number: 20120043204Abstract: The invention provides an enzyme ink useful in test strips that provides a test strip bias, at the low and high glucose ends, falling within a desired target range. The ink of the invention permits an improved method for the production of single calibration code strip lots with good yields.Type: ApplicationFiled: August 23, 2010Publication date: February 23, 2012Applicant: LifeScan Scotland Ltd.Inventors: Gary YOUNG, Michael O'Connell, Ian McArthur, Alan McNeilage, Nick Phippen, Manuel Alvarez-Icaza
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Publication number: 20120018302Abstract: The biosensor unit has a substrate composed of a subcutaneously retained part that is retained under the skin and a base part that is placed on the skin surface. The biosensor unit comprises a sensor part detecting numerical information regarding a substance to be measured as electric signals, a signal amplifying part amplifying the electric signals, a CPU including a calculation part A/D converting the amplified electric signals and processing them to create transmittable data, a storage storing electric signals and data, a transmission part transmitting data to an external device through optical communication, and a battery part for drive. The sensor part is provided on the subcutaneously retained part and the transmission part is provided on the base part.Type: ApplicationFiled: July 26, 2011Publication date: January 26, 2012Applicant: ARKRAY INC.Inventors: Yasunori SHIRAKI, Akihiro YAMAMOTO
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Publication number: 20120018301Abstract: Nanoelectronic devices for the detection and quantification of biomolecules are provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules.Type: ApplicationFiled: April 22, 2011Publication date: January 26, 2012Applicant: NANOMIX, INC.Inventors: Kanchan A. Joshi, Ray Radtkey, Christian Valcke
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Patent number: 8101062Abstract: A method for determining a concentration of an analyte is disclosed. The method includes applying a potential excitation to a fluid sample containing an analyte and determining if a current decay curve associated with the fluid sample has entered an analyte depletion stage. The method also includes measuring a plurality of current values associated with the fluid sample during the analyte depletion stage and calculating an analyte concentration based on at least one of the plurality of current values.Type: GrantFiled: March 24, 2009Date of Patent: January 24, 2012Assignee: Nipro Diagnostics, Inc.Inventor: David Deng
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Publication number: 20110318767Abstract: A measurement of plasma glucose is carried out through the following steps, a sample preparation step (S101, S102) of preparing a measurement sample by hemolyzing hemocytes in blood, a step of measuring whole blood glucose (S103 to S105) of measuring a glucose concentration in whole blood with the measurement sample, and a step of calculating a liquid content ratio of whole blood (S109) of calculating a liquid content ratio of whole blood from a hemocyte/plasma ratio in the blood hemocyte and predetermined ratios of liquid components of hemocytes and of liquid components of plasma.Type: ApplicationFiled: June 13, 2011Publication date: December 29, 2011Applicant: ARKRAY, Inc.Inventors: Takeshi Takagi, Koji Okumura
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Patent number: 8083884Abstract: A method of forming an electrochemical multilayer test sensor that includes a base, a second layer and a reactive layer. The reactive area includes an enzyme. The test sensor is adapted to be used in a meter and assist in determining the concentration of an analyte. A plurality of electrodes and their respective conductive leads are partially defined on the base. After partially defining the plurality of electrodes and their respective conductive leads on the base, the base is attached to a second layer to define a reaction zone in which the plurality of electrodes are fully defined. After attaching the base to the second layer, the plurality of conductive leads on the base of the test sensor are fully defined.Type: GrantFiled: December 21, 2006Date of Patent: December 27, 2011Assignee: Bayer Healthcare LLCInventor: Andrew J. Edelbrock
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Patent number: 8083927Abstract: In vitro analyte sensors and methods of analyte determination are provided. Embodiments include sensors that include a pair of electrodes to monitor filling of the sample chamber with sample.Type: GrantFiled: May 8, 2009Date of Patent: December 27, 2011Assignee: Abbott Diabetes Care Inc.Inventors: Yi Wang, Benjamin J. Feldman, Jared L. Watkin
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Patent number: 8083925Abstract: The present invention provides methods and apparatuses for analyte detection.Type: GrantFiled: December 22, 2009Date of Patent: December 27, 2011Assignee: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Yi Wang, Ting Chen, Lam Tran
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Publication number: 20110308970Abstract: A biosensor comprises a space part for sucking and housing a sample formed of two upper and lower plates, the two plates being stuck together by an adhesive layer, the space part for sucking and housing the sample being constituted so as to be partially opened in the peripheral part and partially closed by the adhesive layer, and has a working electrode having at least glucose oxidase immobilized thereon and a counter electrode on the same plane of the plate.Type: ApplicationFiled: July 12, 2011Publication date: December 22, 2011Inventors: Masao Gotoh, Hiroki Mure, Hiroshi Shirakawa
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Publication number: 20110308945Abstract: A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the photosensor has a planar active surface area for receiving the light from the ECL luminophore and the electrodes are between 0.25 micron and 2 microns thick in a direction normal to the planar active surface area of the photodiodes.Type: ApplicationFiled: June 1, 2011Publication date: December 22, 2011Inventors: Mehdi Azimi, Geoffrey Richard Facer, Alireza Moini, Kia Silverbrook
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Publication number: 20110308944Abstract: The present invention provides an electrochemical sensor comprising a substrate, an electrically conductive layer made of carbon particles which is disposed on the substrate, a cell membrane mimetic structure layer containing an enzyme at least one of inside the cell membrane mimetic structure layer and on the interface of the cell membrane mimetic structure layer which is disposed on the electrically conductive layer.Type: ApplicationFiled: February 4, 2010Publication date: December 22, 2011Applicant: ARKRAY, Inc.Inventors: Koji Katsuki, Yoshiaki Fujinawa, Masashi Tsukada, Yosuke Murase
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Publication number: 20110306076Abstract: The present invention relates to cellobiose dehydrogenases (CDH) having glucose oxidation activity at a pH of 7.4 or above, modifications to modify the pH dependency of the enzymes activity, uses for these CDHs, in particular electrode sensors and electrochemical cells.Type: ApplicationFiled: February 26, 2010Publication date: December 15, 2011Inventors: Roland Ludwig, Dietmar Haltrich, Wolfgang Harreither, Lo Gorton
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Publication number: 20110303538Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.Type: ApplicationFiled: August 22, 2011Publication date: December 15, 2011Inventors: Fei Mao, Adam Heller
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Publication number: 20110303554Abstract: An enzyme electrode that enables rapid degradation of bisphenol-A (BPA) in a contaminated sample and/or monitoring of BPA concentration in a contaminated sample. The enzyme electrode includes a working electrode having one or more selected enzymes that are capable of degrading BPA linked to the working electrode. The selected enzymes linked to the working electrode are capable of degrading BPA at an enhanced rate in response to an applied voltage. The electrode can be used to monitor BPA concentration in a contaminated sample by measuring current flow through the electrode in response to an applied voltage.Type: ApplicationFiled: June 11, 2010Publication date: December 15, 2011Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLCInventor: Shinobu Oguchi
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Publication number: 20110303537Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.Type: ApplicationFiled: August 22, 2011Publication date: December 15, 2011Inventors: Fei Mao, Adam Heller
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Patent number: 8076035Abstract: A fuel cell which utilizes the biogenic metabolism to produce a high current density is provided. The fuel cell generates electric power in such a way that the fuel is decomposed stepwise by a plurality of enzymes and those electrons formed by oxidation are transferred to the electrode. The enzymes work such that the enzyme activity of the enzyme involved in decomposition in the early stage is smaller than the sum of the enzyme activities of the enzymes involved in decomposition in the later stage. In the case where a coenzyme is involved, the enzyme activity of the oxidase that oxidizes the coenzyme is greater than the sum of the enzyme activities of the enzymes involved in the formation of the reduced form of the coenzyme, out of the enzymes involved in the stepwise decomposition of the fuel.Type: GrantFiled: July 25, 2003Date of Patent: December 13, 2011Assignee: Sony CorporationInventors: Hideki Sakai, Takashi Tomita, Ryosuke Takagi, Yusuke Suzuki, Tsuyonobu Hatazawa
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Publication number: 20110297555Abstract: An analyte test element for determining the concentration of at least one analyte in a physiological sample fluid having a first and a second surface in a predetermined distance opposite from each other, said both surfaces are provided with two substantially equivalent patterns forming areas of high and low surface energy which are aligned mostly congruent, whereby the areas with high surface energy create a sample distribution system with at least two detection areas, characterized in that the detection areas of first and second surface are also provided with two corresponding patterns of working and reference electrodes of electrochemical detection means.Type: ApplicationFiled: July 22, 2011Publication date: December 8, 2011Applicant: EGOMEDICAL TECHNOLOGIES AGInventors: Matthias STIENE, Ingrid Rohm
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Publication number: 20110297540Abstract: A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w/w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one ?S value responsive to at least one error parameter.Type: ApplicationFiled: June 6, 2011Publication date: December 8, 2011Applicant: BAYER HEALTHCARE LLCInventors: Amy H. Chu, Huan-Ping Wu, Boru Zhu
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Patent number: 8072008Abstract: A high-sensitivity field effect transistor using as a channel ultrafine fiber elements such as carbon nanotube, and a biosensor using it. The field effect transistor comprises a substrate, a source electrode and a drain electrode arranged on the substrate, a channel for electrically connecting the source electrode with the drain electrode, and a gate electrode causing polarization due to the movement of free electrons in the substrate. For example, the substrate has a support substrate consisting of semiconductor or metal, a first insulating film formed on a first surface of the support substrate, and a second insulating film formed on a second surface of the support substrate, the source electrode, the drain electrode, and the channel arranged on the first insulating film, the gate electrode disposed on the second insulating film.Type: GrantFiled: December 13, 2007Date of Patent: December 6, 2011Assignees: Mitsumi Electric Co., Ltd., Semicon Craft TechnologiesInventors: Koichi Mukasa, Kazuhisa Sueoka, Seiji Takeda, Satoshi Hattori, Yoshiki Yamada, Makoto Sawamura, Hiroichi Ozaki, Atsushi Ishii, Motonori Nakamura, Hirotaka Hosoi
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Patent number: 8070934Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme-based electrochemical sensors. The transition metal complexes include substituted or unsubstituted (pyridyl)imidazole ligands. Transition metal complexes attached to polymeric backbones are also described.Type: GrantFiled: October 31, 2007Date of Patent: December 6, 2011Assignee: Abbott Diabetes Care Inc.Inventors: Fei Mao, Adam Heller
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Publication number: 20110284393Abstract: An electrochemical-based analytical test strip for the determination of an analyte (e.g., glucose) in a bodily fluid sample (such as a whole blood sample) includes an electrically insulating base layer and a patterned conductor layer (for example, a gold patterned conductor layer) disposed over the electrically-insulating layer. The patterned conductor layer includes at least one electrode with the electrode having electrochemically inert areas and an electrochemically active area(s). Moreover, the electrochemically inert areas and electrochemically active area(s) are of a predetermined size and a predetermined distribution such that electrochemical response of the electrode during use of the electrochemical-based analytical test strip is essentially equivalent to a predetermined electrochemical response.Type: ApplicationFiled: May 19, 2010Publication date: November 24, 2011Applicant: LifeScan Scotland LimitedInventors: Gavin MACFIE, Craig Redpath, James Iain Rodgers, Neil Whitehead
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Patent number: 8062488Abstract: A biosensor containing ruthenium, measurement using the same, and the application thereof. The biosensor comprises an extended gate field effect transistor (EGFET) structure, including a metal oxide semiconductor field effect transistor (MOSFET), a sensing unit comprising a substrate, a layer comprising ruthenium on the substrate, and a metal wire connecting the MOSFET and the sensing unit.Type: GrantFiled: July 23, 2009Date of Patent: November 22, 2011Assignee: National Yunlin University of Science and TechnologyInventors: Jung-Chuan Chou, Shih-I Liu
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Patent number: 8057659Abstract: Determination of an analyte such as glucose in a sample is done making use of a plurality of electron transfer reagents, for example two electron transfer reagents, that work together to transfer electrons between the enzyme and the electrodes. The first electron transfer agent is a mediator that interacts with the enzyme after it has acted on the analyte to regenerate enzyme in its active form. The second electron transfer agent is a shuttle that interacts with the electrodes and optionally the mediator. The oxidation and reduction of the shuttle serves as the major source of current that is measured as an indication of analyte.Type: GrantFiled: June 26, 2007Date of Patent: November 15, 2011Assignee: AgaMatrix, Inc.Inventors: Ian Harding, Sridhar Iyengar
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Publication number: 20110266150Abstract: The present invention discloses a biosensor strip, which comprises: a base plate layer defining a first strip end and a second strip end; a conductive layer being disposed on the base plate layer and partitioned into at least two electrode paths; a reagent containing layer being disposed on the conductive layer and comprising a first through hole that is located at the first strip end and for accommodating a reagent solution, wherein the reagent solution comprises matrix, redox mediator, enzyme, surfactant, and a buffer solution; a channel forming layer being disposed on the reagent containing layer and comprising a gap portion that is located at the first strip end; and a cover layer being disposed on the channel forming layer and comprising a second through hole that exposes the partial area of the gap portion of the channel forming layer.Type: ApplicationFiled: April 29, 2010Publication date: November 3, 2011Applicant: PENSIERO MEDICAL ELECTRONICS CORP.Inventor: Chun-Yu CHEN
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Publication number: 20110269648Abstract: A electrochemical sensor system is provided. An example system utilizes electrical and steric properties of contaminants, such as pesticides, herbicides, and heavy metals to measure an ongoing concentration of multiple contaminants simultaneously in real time. An example system has a sensor array including sensors tuned to specific contaminants, each sensor having at least two conducting elements arranged in a capacitive relationship, for example, on a printed circuit board. A binding layer on the conducing elements of each sensor selectively binds a specific contaminant, which produces a signature change in a measureable electrical property, such as impedance. Enclosed sensors and chemical buffers preserve the chemical and physical environment of the contaminants for ongoing real-time measurement of dynamic concentrations. A delivery system enables samples containing contaminants to be automatically delivered to the array of sensors without adulterating the natural state of the samples.Type: ApplicationFiled: May 2, 2011Publication date: November 3, 2011Inventor: ANNE M. SCHWARTZ
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Publication number: 20110259741Abstract: A biosensor includes a first working electrode that a biocatalyst, which has a property that reacts on a specified ground substance, is disposed, a second working electrode that the biocatalyst, which the property is lost, is disposed, and at least one counter electrode for respectively applying a voltage to the first working electrode and the second working electrode.Type: ApplicationFiled: April 21, 2011Publication date: October 27, 2011Applicant: ARKRAY, Inc.Inventors: Yosuke MURASE, Koji KATSUKI
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Publication number: 20110259762Abstract: The biosensor has an electrode system for electrochemically measuring 1,5-anhydroglucitol (1,5-AG) and a reagent layer formed on said electrode system. The reagent layer contains an enzyme for measuring 1,5-anhydroglucitol, phenothiazine compounds, a stabilizer selected from a group of compounds comprising metal salts, organic acids, and amino acids, and an acidic polymer compound as an optional ingredient. The biosensor has excellent storage stability and can electrochemically measure 1,5-anhydroglucitol unaffected by the hematocrit contained in a whole blood sample.Type: ApplicationFiled: December 7, 2009Publication date: October 27, 2011Applicant: NIPPON KAYAKU KABUSHIKI KAISHAInventors: Takao Yokoyama, Hisako Takagi, Yayoi Irie, Reiko Machida, Yoshihiko Umegae
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Patent number: 8038860Abstract: A biosensor can supply a sample solution accurately and easily, and includes a capillary for collecting a sample solution and analyzes a specific substance in the sample solution, an air hole, and at least two supply ports, i.e., a sample supply port and an auxiliary sample supply port, so that supply of the sample solution can be performed from either of the supply ports. Even when the sample supply port is closed up with a fingertip or the like and supply of the sample solution is stopped, the sample solution can be quickly supplied from the other auxiliary sample supply port.Type: GrantFiled: October 20, 2010Date of Patent: October 18, 2011Assignee: Panasonic CorporationInventors: Eriko Yamanishi, Hiroyuki Tokunaga, Akihisa Higashihara
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Publication number: 20110247944Abstract: An electrochemical test sensor for detecting the concentration of an analyte in a sample. The electrochemical test sensor comprises a base that provides a flow path for the fluid test sample having a counter electrode and a working electrode on its surface in electrical communication with a detector of electrical current. The electrochemical test sensor further includes a reagent layer directly located on the surface of the working electrode. The reagent layer includes an enzyme that is adapted to react with the analyte. The electrochemical test sensor further comprises a lid adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the sample thereto. The capillary space is formed with a three-dimensional portion of the lid.Type: ApplicationFiled: June 16, 2011Publication date: October 13, 2011Applicant: BAYER HEALTHCARE LLCInventor: Daniel V. Brown
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Publication number: 20110233073Abstract: The present invention provides a biosensor that can detect anti-HIV antibodies in a biological sample, based on the combined use of a genetically modified, allosteric enzyme, and a matrix with microelectrode networks. One of the benefits of this biosensor is its high sensitivity, simplicity on the detection and portability.Type: ApplicationFiled: March 4, 2011Publication date: September 29, 2011Inventors: Olivier LACZKA, Francisco Javier DEL CAMPO, Francisco Xavier MUÑOZ PASCUAL, Antonio P. VILLAVERDE CORRALES, Neus FERRER MIRALLES, Rosa MarÃa FERRAZ COLOMINA
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Patent number: 8025780Abstract: A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.Type: GrantFiled: February 5, 2009Date of Patent: September 27, 2011Assignee: Panasonic CorporationInventors: Shoji Miyazaki, Hiroyuki Tokunaga, Masaki Fujiwara, Eriko Yamanishi, Yoshinobu Tokuno
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Publication number: 20110230735Abstract: Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.Type: ApplicationFiled: March 14, 2011Publication date: September 22, 2011Applicant: MEDTRONIC MINIMED, INC.Inventors: Katherine T. Wolfe, Ameya S. Kantak, Eric Allan Larson, Daniel E. Pesantez, Dongjuan Xi, Chia-Hung Chiu, Rajiv Shah
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Patent number: 8021528Abstract: A biosensor that is capable of measuring a material contained in a sample is provided. The biosensor is configured to be inserted into a display device, and measures a material contained in the sample. The biosensor includes i) first and second substrates that are opposed to each other; ii) a sample guiding layer that has two sample injection openings and is located on the first substrate; iii) a first electrode that is located between the first substrate and the sample guiding layer; iv) a second electrode that is located between the second substrate and the sample guiding layer; v) a third electrode that is located between the sample guiding layer and the second substrate; and vi) a penetrated opening that penetrates the first substrate, the sample guiding layer, and the second substrate. The second electrode is spaced apart from the first electrode. The biosensor further includes i) a long edge, and ii) a short edge that shares a corner of the biosensor and neighbors the long edge.Type: GrantFiled: March 6, 2008Date of Patent: September 20, 2011Inventor: Yong-Sang Jang
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Publication number: 20110218114Abstract: A nucleotide triphosphate (NTP) participates in a phosphorylation reaction, wherein a phosphate group is transferred from the NTP to a substrate by a kinase. Provision in a kinase reaction of a NTP whose gamma phosphate is conjugated to an electroactive label results in the transfer of the gamma phosphate-electroactive label conjugate from the NTP to the substrate. The electroactive label is an organic moiety such as a quinone or a nitroheterocycle, or is a metallocene such as a ferrocene or a cobaltocene. Upon transfer of the gamma phosphate-electroactive label conjugate to an electrode-bound substrate by a kinase, the phosphorylation event is detected electrochemically by cyclic voltammetry. Phosphorylation can also be detected by mass spectrometry of a substrate carrying the electroactive label-conjugated gamma phosphate.Type: ApplicationFiled: September 26, 2008Publication date: September 8, 2011Inventors: Heinz-Bernhard Kraatz, Kagan Kerman, Haifeng Song
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Patent number: 8007645Abstract: A biosensor can supply a sample solution accurately and easily, and includes a capillary for collecting a sample solution and analyzes a specific substance in the sample solution, an air hole, and at least two supply ports, i.e., a sample supply port and an auxiliary sample supply port, so that supply of the sample solution can be performed from either of the supply ports. Even when the sample supply port is closed up with a fingertip or the like and supply of the sample solution is stopped, the sample solution can be quickly supplied from the other auxiliary sample supply port.Type: GrantFiled: June 23, 2006Date of Patent: August 30, 2011Assignee: Panasonic CorporationInventors: Eriko Yamanishi, Hiroyuki Tokunaga, Akihisa Higashihara
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Publication number: 20110203942Abstract: A sensor chip (200) includes a measuring unit (41) and a measuring unit (42). The measuring unit (41) includes an electrode system (temperature electrodes) having a portion (31) of an electrode (11) and a portion (32) of an electrode (12), and a portion of a capillary (40) containing the portion (31) and the portion (32). The measuring unit (42) includes an electrode system (analysis electrodes) having a portion (33) of a sensor electrode (13) and a portion (34) of an electrode (14), and a portion of a capillary (40) containing the portion (33) and the portion (34) in addition to a reaction reagent layer (20). Data (a) related to the temperature of the blood sample is acquired based on the dimension of a current flowing through the temperature electrodes, and data (b) related to a concentration of an analyte in the blood sample is acquired based on the dimension of a current flowing through the analysis electrodes.Type: ApplicationFiled: November 27, 2009Publication date: August 25, 2011Inventor: Motonori Uchiyama
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Patent number: 8003052Abstract: A diagnostic tape cassette especially for blood sugar tests comprises a test tape which is provided with a plurality of test fields for analysing body fluid, and a housing for receiving the test tape. The housing may have at least one housing part formed from a metal support and moulded-on plastic with integrated functional elements.Type: GrantFiled: June 27, 2007Date of Patent: August 23, 2011Assignee: Roche Diagnostics Operation, Inc.Inventor: Klaus-Dieter Sacherer
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Publication number: 20110198223Abstract: The present invention provides a method of measuring a component in blood, by which the amounts of blood cells and an interfering substance can be measured with high accuracy and high reliability and the amount of the component can be corrected accurately based on the amounts of the blood cells and the interfering substance. In a sensor for measuring a blood component, a first working electrode 13 measures a current that flows during a redox reaction of a blood component, a second working electrode 17 measures the amount of blood cells, and a third working electrode 12 measures the amount of an interfering substance. Next, based on the measurement results, the amount of the blood component to be measured is corrected. Thus, more accurate and precise measurement of the amount of the blood component can be realized.Type: ApplicationFiled: April 26, 2011Publication date: August 18, 2011Applicant: PANASONIC CORPORATIONInventors: Masaki FUJIWARA, Teppei SHINNO, Shin IKEDA
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Publication number: 20110192721Abstract: Methods and devices for automatically distinguishing between a control solution and an actual patient/user sample in a biosensor are provided. The solution is introduced into an electrochemical cell having a working and counter electrode. Electric pulses are applied to the cell and resultant signals are measured. Based on a comparison of the measured signals, a meter can determine whether the sample is a control solution or an actual patient/user sample.Type: ApplicationFiled: February 11, 2011Publication date: August 11, 2011Applicant: Nipro Diagnostics, Inc.Inventors: Natasha D. Popovich, Stephen G. Davies
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Patent number: 7993512Abstract: An electrochemical test sensor for detecting the concentration of an analyte in a sample. The electrochemical test sensor comprises a base that provides a flow path for the fluid test sample having a counter electrode and a working electrode on its surface in electrical communication with a detector of electrical current. The electrochemical test sensor further includes a reagent layer directly located on the surface of the working electrode. The reagent layer includes an enzyme that is adapted to react with the analyte. The electrochemical test sensor further comprises a lid adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the sample thereto. The capillary space is formed with a three-dimensional portion of the lid.Type: GrantFiled: July 5, 2007Date of Patent: August 9, 2011Assignee: Bayer HealthCare, LLCInventor: Daniel V. Brown
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Publication number: 20110186430Abstract: A biosensor for detecting an analyte in a sample of body fluid and methods for manufacturing the biosensor are disclosed. In one embodiment, a biosensor includes at least two electrical conductors embedded within an electrically insulating test element body. The electrical conductors are exposed at two ends of the test element body and a reagent, for example a reagent adapted to test for blood glucose, is applied to one end. In one form, the test element body is cylindrical with a circular or non-circular cross-sectional shape. In other embodiments, the test elements are manufactured by a resin pultrusion process in which resin embedded with electrical conductors is dried or cured, shaped and cut into segments, and reagent applied to one end of each segment.Type: ApplicationFiled: February 2, 2010Publication date: August 4, 2011Inventor: Matthew Carlyle Sauers
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Publication number: 20110186429Abstract: Electrochemical sensors for measuring an analyte in a subject are described. More particularly, devices for measurement of an analyte incorporating a sensor comprising a hydrophilic polymer-enzyme composition covering an electroactive surface providing rapid and accurate analyte levels upon deployment are disclosed.Type: ApplicationFiled: August 25, 2009Publication date: August 4, 2011Applicant: Edwards Lifesciences CorporationInventors: Kenneth Curry, James R. Petisce, Henry Oviatt, Mena Valiket