And Using Semipermeable Membrane Patents (Class 205/778)
  • Patent number: 10533989
    Abstract: The present invention describes a global metabolomic profile of patients with community acquired pneumonia (CAP) and sepsis. The metabolomic profile of endogenous small molecules blood was determined using mass-spectrometry. The global metabolomic profile in plasma demonstrated broad differences between CAP and sepsis patients when comparing those who do and do not survive at 90 days. Increases in specific metabolite biomarkers displayed on a heat map provide early diagnosis of these medical conditions to allow for early intervention and aggressive treatment.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: January 14, 2020
    Assignee: University Of Pittsburgh—Of The Commonwealth System Of Higher Education
    Inventors: John A. Kellum, Christopher W. Seymour
  • Patent number: 10004439
    Abstract: Ceria nanoparticle compositions for use as electrode materials for in vivo electrochemical analyte sensors (e.g., glucose sensors) are provided, for example to form a cathode or a reference electrode. The ceria nanoparticle compositions may be combined with a conductive material (e.g., mixed with) to form the cathode or the reference electrode, or the ceria nanoparticle compositions may be deposited over conductive material to form the cathode or the reference electrode. Electrochemical in vivo sensors for monitoring the concentration of an analyte having a reference electrode and/or a cathode that includes a ceria nanoparticle composition, and methods for monitoring an analyte concentration using the electrochemical sensors are also described. Methods of making in vivo electrochemical analyte sensors having a reference electrode and/or a cathode that includes a ceria nanoparticle composition are also provided.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: June 26, 2018
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Adam Heller
  • Patent number: 9709523
    Abstract: A gas detection apparatus according to an embodiment includes: a collection unit collecting a detection target gas containing a gas molecule to be detected; a detector including a plurality of detection cells each including a sensor unit and an organic probe disposed at the sensor unit, the organic probe capturing the gas molecule collected by the collection unit; a discriminator discriminating the gas molecule by a signal pattern based on an intensity difference of detection signals generated with the gas molecule being captured by the organic probes of the plurality of detection cells; and a reactivation unit applying heat to the organic probe which has the captured gas molecule to be desorbed the gas molecule from the organic probe.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: July 18, 2017
    Assignee: KABUSHIKI KAISHA TOSHIBA
    Inventors: Norikazu Osada, Hirohisa Miyamoto, Ko Yamada, Hiroko Nakamura, Mitsuhiro Oki
  • Patent number: 9567620
    Abstract: A resistive sensor for an analyte comprises a substrate, a conductive polymer layer and an oxidase layer. Hydrogen peroxide is produced via the reaction between analyte and oxidase when a liquid sample is applied to the sensor of the present invention. The produced hydrogen peroxide can oxidize peroxidase, which can be reduced by oxidizing the conductive polymer, thus resulting in decreased conductivity of the conductive polymer for determining the analyte concentration in the liquid sample. The present invention may be used for developing miniaturized and disposable electronic microsensors with high sensitivity and fast response, which can detect analyte level in typical physiological environment for routine monitoring.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: February 14, 2017
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Yu-Lin Wang, Kuan-Chung Fang, Chia-Ho Chu
  • Patent number: 9304099
    Abstract: An electrochemical test sensor for detecting the analyte concentration of a fluid test sample includes a base, a dielectric layer, a reagent layer and a lid. The base provides a flow path for the test sample having on its surface a counter electrode and a working electrode adapted to electrically communicate with a detector of electrical current. The dielectric layer forms a dielectric window therethrough. The reagent layer includes an enzyme that is adapted to react with the analyte. The lid is adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the test sample thereto. At least a portion of the width of the counter electrode is greater than the width of the working electrode.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: April 5, 2016
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Andrew J. Edelbrock, Steven C. Charlton
  • Patent number: 9303310
    Abstract: A method for making multiple single molecule receptors in a nanopore structure includes depositing a first material and a second material by a physical vapor deposition (PVD) technique onto different selected interior surfaces of a nanochannel and functionalizing a surface of the first material, the second material, or both the first and second materials with a chemical compound having at least two functional groups. The first and second materials can be the same or different and form patches having diameters of about 1 to about 100 nanometers (nm). Also disclosed are embodiments of a nanopore structure including multiple single molecule receptors.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: April 5, 2016
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Julia Baldauf, Stefan Harrer, Christine Schieber
  • Patent number: 9297062
    Abstract: A method for making a single molecule receptor in a nanopore structure includes depositing a material by a physical vapor deposition (PVD) technique onto a selected interior surface of a nanochannel and functionalizing a surface of the material with a chemical compound having at least two functional groups. The material forms a patch having a diameter of about 3 to about 10,000 nanometers (nm). Also disclosed are embodiments of a nanopore structure including a single molecule receptor.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: March 29, 2016
    Assignee: GLOBALFOUNDRIES INC.
    Inventors: Julia Baldauf, Stefan Harrer, Christine Schieber
  • Patent number: 9279781
    Abstract: A measuring arrangement for registering a measured variable representing concentration of an analyte in a measured medium, includes: a first electrode modified with a redox active substance, a second electrode, and a measuring circuit, which comprises a voltage source for applying at least one predetermined voltage between the first electrode and a reference, and an apparatus for registering electrical current flowing, in such case, between the first electrode and the second electrode or for registering a variable correlated with the electrical current flowing between the first electrode and the second electrode, wherein the second electrode is modified with the same redox active substance as the first electrode.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: March 8, 2016
    Assignee: ENDRESS + HAUSER CONDUCTA GESELLSCHAFT FUR MESS- UND REGELTECHNIK MBH + CO. KG
    Inventors: Thomas Wilhelm, Michael Hanko
  • Patent number: 9226701
    Abstract: Provided are methods, systems, and apparatus for error detection of bits of a data packet received at a receiver unit by detecting corrupted data bits.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: January 5, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Mark Kent Sloan, Martin J. Fennell
  • Patent number: 9201058
    Abstract: An apparatus and method for sensing time varying ionic current in an electrolytic system having a first fluid chamber and a second fluid chamber separated by a barrier structure is provided, wherein the barrier structure includes thick walls and a substrate having an orifice therein, with the first and second fluid chambers being in communication via the orifice. A potential is applied between electrodes in respective first and second fluid chambers, thus driving an electrical current between them and through the orifice. Total capacitance of the system is less than 10 pF. Analytes are added to one of the first and second fluid chambers and time varying ionic current that passes across the orifice is measured. An amplifier proximal to the barrier structure and electrodes amplifies the ionic current signal.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: December 1, 2015
    Assignee: Electronic Biosciences, Inc.
    Inventors: Andrew D. Hibbs, Melissa Ann Poquette
  • Patent number: 9188578
    Abstract: An anti-retraction capping material is formed on a surface of a nanowire that is located upon a dielectric membrane. A gap is then formed into the anti-retraction capping material and nanowire forming first and second capped nanowire structures of a nanodevice. The nanodevice can be used for recognition tunneling measurements including, for example DNA sequencing. The anti-retraction capping material serves as a mobility barrier to pin, i.e., confine, a nanowire portion of each of the first and second capped nanowire structures in place, allowing long-term structural stability. In some embodiments, interelectrode leakage through solution during recognition tunneling measurements can be minimized.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: November 17, 2015
    Assignee: GLOBALFOUNDRIES INC.
    Inventors: Yann A. N. Astier, Jingwei Bai, Satyavolu S. Papa Rao, Kathleen B. Reuter, Joshua T. Smith
  • Patent number: 9174173
    Abstract: A chemical processing cell includes an upstream membrane and a downstream membrane. The upstream membrane generates a first reaction product. The downstream membrane converts the first reaction product to a second reaction product.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: November 3, 2015
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Dibakar Bhattacharyya, Scott R. Lewis, Saurav Datta
  • Patent number: 9175035
    Abstract: An object of the present invention is to provide, as a method for immobilizing a protein molecule, protein immobilization method and means in which orientation of a molecule to be immobilized can be controlled, the molecule can be stably immobilized without a complicated process and a chemical group used for immobilization does not affect the activity and the function of the protein. Specifically, the present invention relates to a method for immobilizing a molecule including the steps of forming a labeled molecule by attaching a label peptide sequence comprising a hydroxyl group-containing amino acid to a molecule; and bringing a molecule having a phenylboronic acid group into contact with the labeled molecule, to capture the labeled molecule by the molecule having a phenylboronic acid group.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: November 3, 2015
    Assignees: HITACHI, LTD., THE UNIVERSITY OF TOKYO
    Inventors: Tomohiro Konno, Kazuhiko Ishihara, Hirokazu Nishida
  • Patent number: 9105903
    Abstract: The invention relates to an all-solid-state lithium battery and to a method for producing such a battery. The all-solid-state lithium battery includes first and second electrodes separated by a solid electrolyte. The second electrode is formed by a composite material including an electrochemically-active material made of a lithium-ion insertion material, and an amorphous lithium-based material which is an ionic conductor for the lithium ions and which is inert relative to the electrochemically active material.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: August 11, 2015
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Michael Roffat, Frederic Le Cras
  • Patent number: 9085790
    Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane structure with an analyte permeability that is substantially temperature independent. The devices also include a sensing layer disposed on a working electrode of in vivo analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: July 21, 2015
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Udo Hoss, Benjamin J. Feldman, Tianmei Ouyang
  • Patent number: 9005527
    Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: April 14, 2015
    Assignee: Bayer Healthcare LLC
    Inventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
  • Patent number: 8986526
    Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: March 24, 2015
    Assignee: Abbott Point of Care Inc.
    Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
  • Patent number: 8961763
    Abstract: Provided is a device comprising an upper chamber, a middle chamber and a lower chamber, wherein the upper chamber is in communication with the middle chamber through a first pore, and the middle chamber is in communication with the lower chamber through a second pore, wherein the first pore and second pore are about 1 nm to about 100 nm in diameter, and are about 10 nm to about 1000 nm apart from each other, and wherein each of the chambers comprises an electrode for connecting to a power supply. Methods of using the device are also provided, in particular for sequencing a polynucleotide.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: February 24, 2015
    Assignee: The Regents of the University of California
    Inventors: William Dunbar, Jungsuk Kim
  • Patent number: 8951403
    Abstract: A detection method for a sensor membrane formed of europium titanium oxide as part of a biosensor by using PNIPAAm for wrapping enzymes includes adding 1.0 g of NIPAAm powder to 20 ml water, heating same at 60° C. to form NIPAAm solution, and cooling the NIPAAm solution; adding 200 ?l of 98.7 wt % of APS and 50 ?l of 99 wt % of TEMED to the NIPAAm solution, uniformly mixing same, and reacting the mixture for 30 hours to prepare a transparent, gel PNIPAAm; adding 5 mg enzymes to 100 ?l of 1×PBS buffer solution, uniformly mixing same, adding 100 ?l of PNIPAAm to the buffer solution, and uniformly mixing the buffer solution; placing a biosensor on a heater for heating at a constant temperature of 37° C. with the biosensor being an EIS sensor having a sensor membrane formed of EuTixOy; and taking a measurement.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: February 10, 2015
    Assignee: Chang Gung University
    Inventors: Tung-Ming Pan, Chao-Wen Lin, Kung-Yuan Chang, Min-Hsien Wu, Shiao-Wen Tsai
  • Publication number: 20150038410
    Abstract: The present invention is directed to membranes composed of heterocyclic nitrogen groups, such as vinylpyridine and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes described herein demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.
    Type: Application
    Filed: August 19, 2014
    Publication date: February 5, 2015
    Inventors: Benjamin J. Feldman, Tianmei Ouyang, Hyun Cho
  • Patent number: 8906210
    Abstract: A flux limiting layer for an intravenous amperometric biosensor is formed on a substrate to limit a diffusion rate of an analyte from blood to an enzyme electrode. The layer may be formed from ethylene vinylacetate (EVA) dissolved in a solvent such as paraxylene, spray-coated to cover a portion of the electrode, and cured to seal the electrode to the substrate. In a glucose sensor having glucose oxidase disposed on the electrode, thickness and concentration of the EVA layer are optimized to promote a linear output of electrode current as a function of blood glucose concentration.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: December 9, 2014
    Assignee: Edwards Lifesciences Corporation
    Inventor: Kenneth M. Curry
  • Publication number: 20140332409
    Abstract: The present invention is directed to a method and apparatus for an immunoassay technique that uses amperometric measurements to rapidly analyze different pathogenic microorganisms, including bacteria, viruses, toxins, and parasites and chemical compounds using a disposable element. In accordance with one aspect of the present invention, at least one conductive immunosorbent is used to provide support for antibody immobilization and placed on the top of the working electrode; it could also be used by itself as a working electrode. This immunosorbent or powder can be fabricated of conductive material or nonconductive material over which a conductive material is coated. A membrane cover of the working electrode forms a fluidic chamber having a pore size that is suited to the particular application to insure no contact between the working electrode and counter or silver electrode. The immunoassay can be automated using microprocessor control to reduce the amount of human intervention.
    Type: Application
    Filed: May 13, 2013
    Publication date: November 13, 2014
    Inventor: Ebtisam Wilkins
  • Patent number: 8882987
    Abstract: A biosensor measurement system and a method for detecting abnormal measurement in a biosensor, which can significantly enhance the measurement precision without depending on the user's operation manner or the like, can be provided. A voltage application pattern for applying a voltage to a working electrode, a counter electrode, and a detection electrode has a halt period between a first application period and a second application period, and a reduction current measurement value obtained in the first application period is compared with a reduction current measurement value obtained in the second application period, and the measurement values are not outputted when a difference between the measurement values is outside a predetermined range.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: November 11, 2014
    Assignee: Panasonic Healthcare Co., Ltd.
    Inventors: Toshiharu Yoshioka, Eriko Yamanishi, Hiroyuki Tokunaga
  • Publication number: 20140318985
    Abstract: A coated-wire potentiometric sensor comprising an electronically conducting substrate electrode coated with an ionically conductive sensing layer and an outermost surface consisting of or comprising in and/or on a first molecular species which is capable of reversibly adsorbing a second molecular species and a method for measuring the affinity between a first molecular species and a second molecular species comprising the steps of: providing a potentiometric sensor of the coated-wire type having an outermost surface; adapting said outermost surface so that consists of or comprises said first molecular species; placing said sensor in a system for the recording of sensorgrams; recording a sensorgram of the adsorption of a second molecular species on said first molecular species of or comprised in and/or on said adapted outermost surface.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 30, 2014
    Applicant: Universiteit Antwerpen
    Inventors: Karolien DE WAEL, Lucien Nagels, Guido Van Camp
  • Patent number: 8852422
    Abstract: The present invention relates to improved electrochemical biosensor strips and methods for determining the concentration of an analyte in a sample. By selectively measuring a measurable species residing in a diffusion barrier layer, to the substantial exclusion of the measurable species residing exterior to the diffusion barrier layer, measurement errors introduced by sample constituents, such as red blood cells, and manufacturing variances may be reduced.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: October 7, 2014
    Assignee: Bayer HealthCare LLC
    Inventor: Huan-Ping Wu
  • Publication number: 20140262831
    Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 18, 2014
    Inventors: Shankar Balasubramanian, Paul D'Orazio
  • Publication number: 20140209483
    Abstract: Methods and apparatus are provided for manufacturing an analyte detecting device. In one embodiment, the method comprises providing a substrate, applying a plurality of layer of materials on said substrate; applying a layer containing at least one mediator; and screen printing a hydrogel on the layer.
    Type: Application
    Filed: April 1, 2014
    Publication date: July 31, 2014
    Applicant: Sanofi SA
    Inventor: Norbert Bartetzko
  • Patent number: 8771500
    Abstract: Disclosed herein is a device that functions as a glucose sensor. The device has a reference electrode; a counter electrode, a working electrode; an electrically conducting membrane; an enzyme layer; a semi-permeable membrane; a first layer of a first hydrogel in operative communication with the working electrode; the first layer of the first hydrogel being operative to store oxygen; wherein the amount of stored oxygen is proportional to the number of freeze-thaw cycles that the hydrogel is subjected to; and a second layer of the second hydrogel. Disclosed too is a method that comprises using periodically biased amperometry towards interrogation of implantable glucose sensors to improve both sensor's sensitivity and linearity while at the same time enable internal calibration against sensor drifts that originate from changes in either electrode activity or membrane permeability as a result of fouling, calcification and/or fibrosis.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: July 8, 2014
    Assignee: The University of Connecticut
    Inventors: Fotios Papadimitrakopoulos, Santhisagar Vaddiraju
  • Patent number: 8771486
    Abstract: The present disclosure provides an orientation-nonspecific sensor port for use in analyte meters designed to detect and quantify analyte levels in a fluid sample along with methods of using the same. The present disclosure also provides compositions and methods for facilitating the correct insertion of a sensor into a corresponding analyte meter.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: July 8, 2014
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Yi Wang, Benjamin J. Feldman, Benjamin Rush, Charlene Haley
  • Patent number: 8764954
    Abstract: The present disclosure provides an orientation-nonspecific sensor port for use in analyte meters designed to detect and quantify analyte levels in a fluid sample along with methods of using the same. The present disclosure also provides compositions and methods for facilitating the correct insertion of a sensor into a corresponding analyte meter.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: July 1, 2014
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Yi Wang, Benjamin J. Feldman, Benjamin Rush, Charlene Haley
  • Patent number: 8758583
    Abstract: The present disclosure provides an orientation-nonspecific sensor port for use in analyte meters designed to detect and quantify analyte levels in a fluid sample along with methods of using the same. The present disclosure also provides compositions and methods for facilitating the correct insertion of a sensor into a corresponding analyte meter.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: June 24, 2014
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Yi Wang, Benjamin J. Feldman, Benjamin Rush, Charlene Haley
  • Patent number: 8728299
    Abstract: The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: May 20, 2014
    Assignee: Bayer HealthCare LLC
    Inventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
  • Patent number: 8702961
    Abstract: According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: April 22, 2014
    Assignee: Bayer HealthCare LLC
    Inventors: Dijia Huang, Steven C. Charlton, Suny J. George, Andrew J. Edelbrock
  • Patent number: 8702965
    Abstract: The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: April 22, 2014
    Assignee: Bayer HealthCare LLC
    Inventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
  • Patent number: 8702923
    Abstract: Disclosed is a method of measuring sample reaction results on a biosensor having a working electrode and other electrodes, including: applying voltage between the working electrode and each of the other electrodes and detecting the amount of current flowing through the working electrode to determine whether or not a sample is injected; applying voltage between the working electrode and one of the other electrodes and re-detecting the amount of current flowing through the working electrode; and acquiring and displaying a concentration value as a sample reaction result corresponding to the amount of detected current.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: April 22, 2014
    Assignee: Infopia Co., Ltd.
    Inventors: Byeong-woo Bae, Sung-dong Lee, Hong-seong Suk, Jin-a Yoo
  • Patent number: 8691072
    Abstract: Voltage is applied across a counter electrode and a working electrode, with which a blood sample is in contact, in such a state that an oxidant in a redox substance is not substantially in contact with a working electrode but is in contact with a counter electrode and a reductant is not substantially in contact with the counter electrode but is in contact with the working electrode, whereby the reductant and the oxidant are respectively oxidized and reduced to measure current produced upon the oxidation and reduction. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, the Hct value of the blood sample can be measured stably with a satisfactory detection sensitivity. This measurement can be carried out with a sensor chip comprising a working electrode (11), a counter electrode (12), and a blood sample holding part (14) having branch parts (18a, 18b).
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: April 8, 2014
    Assignee: Panasonic Corporation
    Inventors: Masaki Fujiwara, Shin Ikeda, Takahiro Nakaminami
  • Patent number: 8679308
    Abstract: Embodiments of the present invention relate to a sensor membrane. The sensor membrane comprises one or more conversion layers wherein the one or more conversion layers are capable of converting a non-charged analyte into a charged species, one or more polymeric layers wherein the one or more polymeric layers act as matrices to host the one or more conversion layers and wherein the one or more conversion layers and one or more polymeric layers create oppositely charged regions within the membrane.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: March 25, 2014
    Assignee: Honeywell International Inc.
    Inventor: Yuandong Gu
  • Patent number: 8679309
    Abstract: An electrochemical test sensor includes a lid and a base. The base has a length and a width. The length of the base is greater than the width of the base. The base includes at least a working electrode, a counter electrode and at least three test-sensor contacts for electrically connecting to a meter. The at least three test-sensor contacts are spaced along the length of the base from each other. The base and the lid assist in forming a fluid chamber for receiving the fluid sample. The electrochemical test sensor further includes a reagent to assist in determining the concentration of the analyte in the fluid sample.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: March 25, 2014
    Assignee: Bayer HealthCare LLC
    Inventors: Greg P. Beer, John P. Creaven
  • Patent number: 8666470
    Abstract: The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: March 4, 2014
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Adam Heller, Pawel Rowinski, Benjamin Feldman
  • Patent number: 8652320
    Abstract: A biosensor strip having a low profile for reducing the volume of liquid sample needed to perform an assay. In one embodiment, the biosensor strip includes an electrode support; an electrode arrangement on the electrode support; a cover; a sample chamber; and an incompressible element placed between the cover and the electrode support, the incompressible element providing an opening in at least one side or in the distal end of the sample chamber to provide at least one vent in the sample chamber. In another embodiment, the biosensor strip has an electrode support; an electrode arrangement on the electrode support; a cover; and a sample chamber, the cover having a plurality of openings formed therein, at least one of the openings in register with the sample chamber. The invention further includes methods for preparing such a biosensor strips in a continuous manner.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: February 18, 2014
    Assignee: Abbott Laboratories
    Inventors: Adrian Petyt, Matthew Bates, Pamela Reid, Andrew J. Bull, Jeff Garner
  • Publication number: 20140001056
    Abstract: The invention relates to a method of inhibiting the insertion of one or more membrane proteins into a lipid bilayer. The invention also relates to a method of inserting a pre-determined number of membrane proteins into a lipid bilayer and lipid bilayers having a pre-determined number of membrane proteins inserted therein. The lipid bilayers of the invention are useful as sensor arrays, particularly for sequencing nucleic acids.
    Type: Application
    Filed: January 11, 2012
    Publication date: January 2, 2014
    Applicant: ISIS INNOVATION LIMITED
    Inventors: John Hagan Pryce Bayley, Pinky Raychaudhuri
  • Patent number: 8617368
    Abstract: The present invention relates to an analytical tool (X) which includes a substrate (1), a flow path for moving a sample along the substrate (1), a reagent portion (14) provided in the flow path, and an insulating film (13) covering the substrate (1) and including an opening (15a) for defining a region for forming the reagent portion (14). The insulating film (13) further includes at least one additional opening (15b) positioned in a longitudinal direction (N1) relative to the opening (15a). For instance, the flow path is configured to move the sample by capillary force.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: December 31, 2013
    Assignee: Arkray, Inc.
    Inventor: Taizo Kobayashi
  • Patent number: 8617382
    Abstract: A sensor array with at least three electrodes and a switching unit is disclosed, as well as a process for operating such a sensor array for implementing an electrochemical analysis process. The at least three electrodes can be selectively switched as counter-electrodes or as a working electrode which can be electrically coupled to an electrolytic analyte. The at least three electrodes are set up in such a way that sensor events occur at an electrode switched as working electrode in the electrolyte solution, in the presence of the electrolytic analyte. The electrodes which are not required as working electrodes at a particular point in time for detecting the electrolytic analyte can thus be switched together to form the counter-electrode of the sensor array, thus dispensing with the need for a separate counter-electrode.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: December 31, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventor: Christian Paulus
  • Patent number: 8617365
    Abstract: An electrochemical test device is provided having a base layer with a first electrode thereon and a top layer with a second electrode thereon. The two electrodes are separated by a spacer layer having an opening therein, such that a sample-receiving space is defined with one electrode on the top surface, the other electrodes on the bottom surface and side walls formed from edges of the opening in the spacer. Reagents for performing the electrochemical reaction are deposited on one of the electrodes and on the side walls of the sample-receiving space.
    Type: Grant
    Filed: May 21, 2005
    Date of Patent: December 31, 2013
    Assignee: AgaMatrix, Inc.
    Inventor: Ian Harding
  • Publication number: 20130334062
    Abstract: A handheld device for analysis of electro-physiological properties of a cellular membrane ion channel in an ion channel containing lipid cellular membrane comprises a handheld body with a pump and an electronic controller, and a disposable pipette tip comprising a pathway for fluid, said pathway connecting an open end of the pipette tip to an analysis substrate comprised in the pipette tip. The substrate is adapted to transmit an electrical current through the ion channel in said ion channel-containing lipid cellular membrane, when said lipid cellular membrane is held at a predetermined site of the substrate, e.g. for patch clamp analysis. The handheld body and the disposable pipette tip are configured to releasably attach the pipette tip to the body, to provide a hydraulic connection between the pump of the handheld body and said pathway, and to provide an electric connection between the electronic controller and at least one of said electrodes of the substrate.
    Type: Application
    Filed: February 29, 2012
    Publication date: December 19, 2013
    Applicant: SOPHION BIOSCIENCE A/S
    Inventors: Jonatan Kutchinsky, Nicholas Byrne, Christopher Mathes, Jens Henneke
  • Patent number: 8574424
    Abstract: A method for determining a concentration of an analyte is disclosed. The method includes applying a potential excitation to a fluid sample containing an analyte and determining if a current decay curve associated with the fluid sample has entered an analyte depletion stage. The method also includes measuring a plurality of current values associated with the fluid sample during the analyte depletion stage and calculating an analyte concentration based on at least one of the plurality of current values.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: November 5, 2013
    Assignee: Nipro Diagnostics, Inc.
    Inventor: David Deng
  • Patent number: 8557567
    Abstract: The present invention relates to a method of fabricating a nanogap and a nanogap sensor, and to a nanogap and a nanogap sensor fabricated using the method. The present invention relates to a method of fabricating a nanogap and a nanogap sensor, which can be realized by an anisotropic etching using a semiconductor manufacturing process. According to the method of present invention, the nanogap and nanogap sensor can be simply and cheaply produced in large quantities.
    Type: Grant
    Filed: September 5, 2006
    Date of Patent: October 15, 2013
    Assignee: Micobiomed. Co., Ltd.
    Inventors: Bong hyun Chung, Sang kyu Kim, Hye jung Park
  • Publication number: 20130264221
    Abstract: A membrane electrode includes a novel sensor combining a filtering function of a membrane and a signal measuring ability of an electrode. A target material may be measured by filtration through the membrane. A small amount of target materials may be detected with high sensitivity using an amplified electrical signal by increasing electrical conductivity by reducing metal ions on the membrane, and thus the target material may be subject to quantitative analysis. In addition, only a target material selectively binding to a receptor may be filtrated by passing a sample through the membrane after a receptor material is fixed to the electrode, and thus may be used to detect an electrical signal. In addition, the sensor may measure a signal in various methods such as electrical conductivity, impedance, etc.
    Type: Application
    Filed: December 16, 2011
    Publication date: October 10, 2013
    Inventors: Min Gon Kim, Jun Hyoung Ahn, Yun Ju Sung, Yong Beom Shin, Hyo Arm Joung
  • Patent number: 8543182
    Abstract: Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: September 24, 2013
    Assignee: Metronom Health, Inc.
    Inventors: Elliot Botvinick, Troy M. Bremer
  • Patent number: RE44521
    Abstract: An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: October 8, 2013
    Assignee: Bayer HealthCare LLC
    Inventors: Matthew K. Musho, J. Oakey Noell, Andrew J. Edelbrock, Dijia Huang