Electrolytic Analysis Or Testing (process And Electrolyte Composition) Patents (Class 205/775)
  • Patent number: 12007358
    Abstract: A rail-to-rail potentiostat may require an offset current in order to support a bidirectional work electrode current at a work electrode. This offset current may improve measurements of the work electrode current made a dual-slope analog-to-digital converter, especially when the work electrode current is small, but can also lead to inaccuracies (e.g., due to a temperature coefficient) if it is not properly calibrated. Accordingly, bidirectional potentiostat is disclosed that can be configured in a normal configuration for measurement of a work electrode current or a calibration configuration for measurement (i.e., calibration) of an offset current. The reconfigurability allows calibrations to be taken as needed, on a schedule, or as specified by a user. The reconfigurability can also allow for maintaining a work electrode voltage and a work electrode current during calibration so that an electrochemical experiment using a cell coupled to the bidirectional potentiostat is unaffected by the calibration.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: June 11, 2024
    Assignee: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLC
    Inventor: Moez Kanoun
  • Patent number: 11969245
    Abstract: Disclosed is an analyte measuring patch for invasive measuring a concentration of an analyte, in particular glucose. The analyte measuring patch includes a sensor with a working electrode (101), a counter electrode (103) and a reference electrode 102). The patch further includes an electronics unit with a microcontroller (1200) and a current measurement unit. The microcontroller (1200) includes a control output (DAC), a first analogue input (ADC-1) and a second analogue input (ADC-2). The control output (DAC) is operatively coupled with a control electrode, the control electrode being either of the working electrode or (101) or the counter electrode (103). The first analogue input (ADC-2) is operatively coupled with a measurement electrode via the current measurement unit, the measurement electrode being either of the working electrode (101) or the counter electrode (103). The second analogue input (ADC-1) is operatively coupled with the reference electrode (102).
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: April 30, 2024
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Karl-Heinz Koelker, Frederic Wehowski
  • Patent number: 11913941
    Abstract: A disclosed system uses modulations of ionic current across a nanopore in a membrane to detect target molecules passing through the nanopore. This principle has been applied mainly to nucleic acid sequencing, but can also be used to detect other molecular targets such as proteins and small molecules. In addition, the system delivers target molecules to a nanopore to provide label-free single molecule analysis using a chip-based system. Target molecules are concentrated on microscale carrier beads, and the beads are delivered and optically trapped in an area within the capture radius of the nanopore. The target molecules are released from the beads and detected using nanopore current modulation. In addition, the disclosed system combines sample preparation (e.g. purification, extraction, and pre-concentration) with nanopore-based readout on a microfluidic chip.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: February 27, 2024
    Assignees: The Regents of the University of California, Brigham Young University
    Inventors: Holger Schmidt, Aaron Roe Hawkins, David W. Deamer
  • Patent number: 11835481
    Abstract: A biosensor component is provided that provides enhanced characteristics for use in biosensors, such as blood glucose sensors. The biosensor component comprises a substrate and a conductive layer coated on the substrate. The conductive layer includes nickel, chromium, and iron, such that a combined weight percent of the nickel and chromium in the conductive layer is in the range of 80 to less than 95 weight percent, and the weight percent of iron in the conductive layer is greater than 5 weight percent and less than 12 weight percent.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: December 5, 2023
    Assignee: Eastman Chemical Company
    Inventors: Spencer Erich Hochstetler, Senthil Nathan Sambandam, Dennis Lee Ashford, II
  • Patent number: 11786897
    Abstract: A magnetic shape memory (MSM) microfluidic device may include a flexible membrane positioned between a channel and an MSM element. The MSM element may engage the flexible membrane to deform the channel at portions of the flexible membrane that are adjacent to non-contracted portions of the MSM element. The flexible membrane may prevent contact between a fluid within the channel and the MSM element. Magnetic field components may be applied to the MSM element and moved along the MSM element enable fluidic flow within the channel while. The device may include an upper portion including the flexible membrane and a lower portion including the MSM element. The upper portion may be interchangeable with additional upper portions.
    Type: Grant
    Filed: February 22, 2022
    Date of Patent: October 17, 2023
    Assignee: Boise State University
    Inventors: Peter Mullner, Geoffrey Brent Johnston, Aaron Smith, Andrew Armstrong
  • Patent number: 11768160
    Abstract: A multiparameter standard solution for verifying and calibrating water quality sensors containing an aqueous pH buffer, a xanthene dye, and distyryl biphenyl (DSBP) is provided. The standard solution provides a safe, quick, easy, and stable field standard to simultaneously conduct calibration analysis for several sensors at once. The standard solution is stable when stored and can be safely disposed of in the field. Methods of calibrating sensors used in water quality analysis using the multiparameter standard solution are also provided.
    Type: Grant
    Filed: November 21, 2020
    Date of Patent: September 26, 2023
    Assignee: U.S. Geological Survey
    Inventors: Brian Anthony Pellerin, Angela Merleen Hansen
  • Patent number: 11579067
    Abstract: The disclosure relates to an apparatus and associated method for concentration of polarizable molecules within a fluid medium. The apparatus comprising a structure defining a cavity, having a cross-sectional dimension of 200 nm or less; at least two translocation electrodes positioned relative to the structure to enable generation of a DC electric field passing through the cavity; and at least two trapping electrodes positioned relative to the structure to enable generation of a time-varying electric field proximal to the cavity inlet.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: February 14, 2023
    Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITED
    Inventors: Joshua Benno Edel, Kevin Joseph Freedman
  • Patent number: 11523757
    Abstract: An electrochemical sensor including a working electrode having an arrangement of pillars defining channels between the pillars. The channels increase confinement of a byproduct produced in an electrochemical reaction used during sensing of an analyte, so as to increase interaction of the byproduct with the working electrode. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: December 13, 2022
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Zhenzhong Sun, Xin Heng, Rui Kong
  • Patent number: 11413595
    Abstract: Provided is a fluid flow device having high freedom of choosing means for detecting flow errors. The fluid flow device includes a channel forming body. The channel forming body forms a plurality of fluid channels, a plurality of detection spaces corresponding to the fluid channels, respectively, and a plurality of communication channels providing respective communications between the fluid channels and the detection spaces corresponding thereto, respectively. Each of the detection spaces contains a detection fluid and a detection gas aligned in a longitudinal direction thereof, and an interface is formed therebetween. The detection gas is contained in the detection space so as to allow the position of the interface to be changed with the pressure change of a processing object fluid that flows through the fluid channels.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: August 16, 2022
    Assignee: Kobe Steel, Ltd.
    Inventors: Akira Matsuoka, Koji Noishiki, Tomohiro Ozono
  • Patent number: 11391720
    Abstract: The present disclosure relates to a cell potential detection apparatus that can prevent a culture solution from being contaminated by a component harmful to cells, a method for manufacturing the cell potential detection apparatus, and an information processing system. The cell potential detection apparatus includes a cell potential detection chip including an electrode section configured to detect a potential of a cell, a member included in a liquid storage section configured to store a culture solution for the cell, and a film covering a liquid contact surface of the member and being harmless to the cell, the liquid contact surface being configured to contact the culture solution. The present technology can be applied to, for example, a semiconductor module in which a chip for detecting a potential at an action potential generation point generated due to a chemical change in a cell is packaged.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: July 19, 2022
    Assignee: SONY CORPORATION
    Inventors: Masataka Maehara, Masato Kawashima
  • Patent number: 11390920
    Abstract: A system for nucleic acid sequencing includes a machine-readable memory and a processor configured to execute machine-readable instructions. The instructions, when executed by the processor, cause the system to expose template polynucleotide strands in a plurality of defined spaces of a sensor array to a series of flows of nucleotide species, the series comprising a sequence of random flows; and obtain, for each of the series of flows of nucleotide species, a signal indicative of how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: July 19, 2022
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Earl Hubbell, Jonathan Schultz
  • Patent number: 11360537
    Abstract: The technology described herein is related to a two-phase deployment-initiated wakeup mechanism for a body-mountable electronic device. During a first phase of the two-phase wakeup mechanism, a motion sensor detects an acceleration event indicative of deployment of the device onto the body of the user. During a second phase of the two-phase mechanism, control circuitry can be adapted to be enabled by the acceleration event. Once enabled, the control circuitry can verify that the device has been launched onto the body of a user via a deployment applicator in which the device is retained until deployment. Once verified, the control circuitry can wake up the body-mountable electronic device by transitioning the device from a sleep state to a functional (or operational) state.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: June 14, 2022
    Assignee: Verily Life Sciences LLC
    Inventors: William James Biederman, III, Louis Hyunsuk Jung
  • Patent number: 11354666
    Abstract: Systems and methods that facilitate authenticating a user making a payment using microelectromechanical systems (MEMs) devices (i.e., smart dust). The MEMs devices may have sensors that collect data and transfer it to a base station device. The MEMs devices can collect sensor data, including biometric data and/or capture images of the person. The MEMs can also collect sensor data such as audio data, optical data, temperature data, pressure data, and motion data and compare it to data associated with a user profile to determine that the person making the payment is the same person associated with the user profile. Once the person's identity has been confirmed, and thus authenticated, the payment request can be confirmed and payment made, via either the mobile device or credit card.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: June 7, 2022
    Assignee: Wells Fargo Bank, N.A.
    Inventors: Rameshchandra Bhaskar Ketharaju, Sarath Chava, Prasad N. Sivalanka, Madhu V. Vempati
  • Patent number: 11346836
    Abstract: A nanopore cell includes a conductive layer and a working electrode disposed above the conductive layer and at the bottom of a well into which an electrolyte may be contained, such that at least a portion of a top base surface area of the working electrode is exposed to the electrolyte. The nanopore cell further includes a first insulating wall disposed above the working electrode and surrounding a lower section of a well, and a second insulating wall disposed above the first insulating wall and surrounding an upper section of the well, forming an overhang above the lower section of the well. The upper section of the well includes an opening that a membrane may span across, and wherein a base surface area of the opening is smaller than the at least a portion of the top base surface area of the working electrode that is exposed to the electrolyte.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: May 31, 2022
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: John Foster, Morgan Mager
  • Patent number: 11315662
    Abstract: The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: April 26, 2022
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Charles M. Clinton, Xinri Cong, Eli N. Glezer, Sudeep Kumar, Carl Stevens, Michael Vock, Jon S. Willoughby
  • Patent number: 11238719
    Abstract: The technology relates to portable personal monitor device and associated methods. In particular, the technology provides for improving the capability of personal monitor device systems by enabling functions such as two-way communications from the personal monitor; associating possible threats with one or more locations; and dynamically determining safe locations and potential evacuation routes. Also described herein are monitors which improve the detection of possible threats or risks by allowing a base unit to be used with various replacement sensor modules.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: February 1, 2022
    Assignee: Blackline Safety Corp.
    Inventors: Sean Stinson, Kirk Johnson, Kelly Englot, Phillip Benson, Barry Moore, Steven Daeninck
  • Patent number: 11213231
    Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: January 4, 2022
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Jenn-Hann Larry Wang, Michael E. Miller, Raghavendhar Gautham, Yiwen Li, Rajiv Shah
  • Patent number: 11215581
    Abstract: An electric transmission mechanism according to one aspect of the present invention may include a tubular ring fixed to a shaft electively connected to an electrode, at least one brush slidably contacting with a circumferential surface of the ring, a bearing including an inner race fixed to the ring, and a housing which is fixed to an outer race of the bearing and accommodates a contact part of the ring and the brush therein.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: January 4, 2022
    Assignee: Yokogawa Electric Corporation
    Inventors: Takeshi Kuwagata, Megumi Goto, Hikaru Shimizu, Saori Handa, Yukiko Hirano, Masaru Homma, Atsushi Otaki, Hideyuki Yagihashi
  • Patent number: 11175260
    Abstract: A nanopore device for molecular characterization that includes a supporting substrate. The supporting substrate has at least one nanopore where the nanopore is a carbon nanotube of a first diameter. The nanodevice is configured to provide a stimulus to the carbon nanotube causing the first diameter to change to a second diameter. The nanopore device also includes a device configured to apply the stimulus to the nanopore. The nanopore device further includes an electrical circuit configured to measure an electrical property across the nanopore, where there is a change in the electrical property when a molecule traverses the nanopore.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: November 16, 2021
    Assignee: International Business Machines Corporation
    Inventors: Priscilla Racquel Rogers, James R. Kozloski
  • Patent number: 11169059
    Abstract: A chemical substance concentrator is configured to concentrate a chemical substance contained in a gaseous sample. The concentrator includes a flow passage having a hollow part allowing the gaseous sample flows through the hollow part, first and second electrodes disposed on an inner wall of the flow passage, an electrode wiring connected to the first and second electrodes, a material layer disposed on the electrode wiring, and an adsorbent disposed on the material layer. The adsorbent is configured to adsorb the chemical substance and to desorb the adsorbed chemical substance. The chemical substance concentrator is capable of efficiently desorbing the adsorbed chemical substances.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: November 9, 2021
    Assignee: PANASONIC CORPORATION
    Inventors: Atsuo Nakao, Yosuke Hanai
  • Patent number: 11165921
    Abstract: An image forming apparatus includes a housing, an discharge tray, a discharging roller pair, a main board, a wireless communication unit including a first wireless communication board. The housing includes a first part and a second part. The first part is arranged at a downstream side of a nip of the discharging roller pair, and an upper surface of a side wall of the first part is arranged at a lower position with respect to the nip. In the second part, the discharging roller pair is positioned. The second part is arranged at an upstream side of the first part. An upper surface of a side wall of the second part is arranged at a higher poison with respect to first part. At least part of the wireless communication unit is arranged at a higher poison with respect to the side wall of the first part.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: November 2, 2021
    Assignee: Brother Kogyo Kabushiki Kaisha
    Inventor: Tomohiro Wada
  • Patent number: 11150145
    Abstract: Disclosed herein are methods and systems for conserving energy of a power source of an analyte monitoring device. Also disclosed herein are methods and systems for reducing noise during data transmissions to and from the analyte monitoring device.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: October 19, 2021
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Saeed Nekoomaram, Martin J. Fennell, Mark Kent Sloan, Lei He, Jeffery Mario Sicurello
  • Patent number: 11105768
    Abstract: The present disclosure relates to a method for producing an exchangeable electrode assembly, with at least one sensor body and at least a first electrode, for an electrochemical sensor for determining the concentration of an analyte in a gaseous or liquid measurement medium, a corresponding electrode assembly, and an electrochemical sensor with an electrode assembly according to the present disclosure. In order to produce the electrode assembly, the following method steps are performed: providing a sensor body, and applying at least a first electrically-conductive material to a first sub-region of the sensor body for producing a first electrode of the electrode assembly.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: August 31, 2021
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventors: Erik Hennings, Jens Vettermann, Christian Fanselow
  • Patent number: 11067526
    Abstract: This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: July 20, 2021
    Assignee: Abbott Point of Care Inc.
    Inventors: Michael Louie Low, Barry Bass, Sergey Gershtein
  • Patent number: 11060994
    Abstract: This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: July 13, 2021
    Assignee: Abbott Point of Care Inc.
    Inventors: Michael Louie Low, Barry Bass, Sergey Gershtein
  • Patent number: 10996186
    Abstract: Provided is a method for measuring a component of a biological sample with a biosensor provided with: a capillary for introducing the biological sample; an electrode part including a first electrode system that includes a first working electrode and a first counter electrode in the capillary; and a reagent part disposed so as to be in contact with the electrode part, the reagent part containing an enzyme and a mediator, and the method including a step of starting voltage application for a duration longer than 0 second and up to 0.7 second to the first electrode system within 0 second to 0.5 second after detection of the introduction of the biological sample to obtain a hematocrit value based on a current value obtained thereby.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: May 4, 2021
    Assignee: PHC Holdings Corporation
    Inventors: Shouko Hironaka, Eriko Yoshioka, Daiki Mizuoka, Suguru Sasaki
  • Patent number: 10983087
    Abstract: A structure of an electrochemical unit includes a substrate, a first metal layer disposed on the substrate, and an array of electrochemical cells disposed on the first metal layer. The array of the electrochemical cells includes a plurality of electrochemical cells. Each of the electrochemical cells includes the first metal layer disposed on the substrate, a first electrode disposed on the first metal layer, a polymer layer disposed on the substrate and adjacent to the first metal layer and the first electrode. A second metal layer is disposed on the polymer layer, and a second electrode is disposed on the second metal layer. A pore is constituted between the polymer layers of every the two electrochemical cells. A cavity located above the first electrode is defined between every the two electrochemical cells, wherein the cavity is communicated with the pore.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: April 20, 2021
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jui-Chin Chen, Pei-Jer Tzeng
  • Patent number: 10928346
    Abstract: A sensor probe having a first sensing element and a second sensing element. The first sensing element generates current changes in response to changes in a relative amount of a target element present in reference air versus a first exhaust gas chamber of the sensor probe. A second sensing element generates current changes in response to changes in a relative amount of the target element present in the first exhaust gas chamber and either a second exhaust gas chamber of the sensor probe or reference air.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: February 23, 2021
    Assignee: DENSO International America, Inc.
    Inventors: Jonathan Logan, Michael Lewis, Rafal Kaput, Blaise Friery
  • Patent number: 10926486
    Abstract: Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: February 23, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Roger J. A. Chen, Randy Davis
  • Patent number: 10914735
    Abstract: Accordingly, in some embodiments methods for detecting an analyte or analytes in one or more sample(s) are provided. The methods encompass providing a solid support with an addressable marker and an associated ligand, contacting the solid substrate to a sample, thereby forming a contacted solid support, associating the contacted solid support with a FET array and detecting the electrical properties of the FET array and thereby detecting an analyte or analytes in one or more samples. In other embodiments, the sample encompasses a second addressable marker.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: February 9, 2021
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Scott Conradson, David Dinauer, Bin Zhao, Dmitriy Gremyachinskiy, Jason Myers, Jeffrey Rossio, Victoria Singer, Kristina Giorda
  • Patent number: 10900925
    Abstract: ISEs comprising a substrate layer; a carbon nanotube layer disposed on the substrate layer; a conductive metal layer on a portion of the carbon nanotube layer; a conductive polymer disposed on the portion; and an ion-selective membrane disposed on the conductive polymer and methods of making them are provided. A system is also provided for detecting a plurality of analyte ions in a sample comprising a housing; a plurality of ISEs associated with the housing, each electrode comprising an ion-selective membrane to a different analyte ion; a reference electrode associated with the housing; a fluid sample receptacle associated with the housing and in fluid communication with the plurality of ion-selective electrodes and reference electrode.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: January 26, 2021
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Karin Y. Chumbimuni-Torres, Samantha Mensah, Percy Calvo-Marzal, Michelle Rich
  • Patent number: 10883958
    Abstract: A liquid electrolyte, for an electrochemical gas sensor for detecting NH3 or gas mixtures containing NH3, contains at least one solvent, one conductive salt and/or one organic mediator. The conductive salt is an ionic liquid, an inorganic salt, an organic salt or a mixture thereof. The electrolyte preferably is comprised of (I) water, propylene carbonate, ethylene carbonate or a mixture thereof as solvent; (ii) LiCl, KCl, tetrabutylammonium toluenesulphonate or 1-hexyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate as conductive salt; and (iii) tert-butylhydroquinone or anthraquinone-2-sulphonate as organic mediator.
    Type: Grant
    Filed: September 1, 2014
    Date of Patent: January 5, 2021
    Assignee: Dräger Safety AG & Co. KGaA
    Inventors: Andreas Nauber, Michael Sick, Gregor Steiner, Marie-Isabell Mattern-Frühwald, Rigobert Chrzan, Sabrina Sommer, Frank Mett, Andreas Hengstenberg
  • Patent number: 10832798
    Abstract: Methods for analyzing signal data generated by sequencing of a polynucleotide strand using a pH-based method of detecting nucleotide incorporation(s). In an embodiment, the method comprises formulating a function that models the output signal of a representative empty well of a reactor array. A time transformation is applied to the empty well function to obtain a time-warped empty well function. The time-warped empty well function is fitted to an output signal from the loaded well representative of a flow that results in a non-incorporation event in the loaded well. The fitted time-warped empty well function can then be used to analyze output signals from the loaded well for other flows.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: November 10, 2020
    Assignee: Life Technologies Corporation
    Inventor: Earl Hubbell
  • Patent number: 10833340
    Abstract: The present invention relates to methods and apparatuses for determining the ratio of oxidized and reduced forms of a redox couple in solution, each method comprising: (a) contacting a first stationary working electrode and a first counter electrode to the solution; (b) applying a first potential at the first working electrode and measuring a first constant current; (c) applying a second potential at the first working electrode and measuring a second constant current; wherein the sign of the first and second currents are not the same; and wherein the ratio of the absolute values of the first and second currents reflects the ratio of the oxidized and reduced forms of the redox couple in solution.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: November 10, 2020
    Assignee: Lockheed Martin Energy, LLC
    Inventors: Evan R. King, Kean Duffey, Adam Morris-Cohen, John Goeltz, Steven Y. Reece
  • Patent number: 10809243
    Abstract: A nanopore cell includes a conductive layer and a working electrode disposed above the conductive layer and at the bottom of a well into which an electrolyte may be contained, such that at least a portion of a top base surface area of the working electrode is exposed to the electrolyte. The nanopore cell further includes a first insulating wall disposed above the working electrode and surrounding a lower section of a well, and a second insulating wall disposed above the first insulating wall and surrounding an upper section of the well, forming an overhang above the lower section of the well. The upper section of the well includes an opening that a membrane may span across, and wherein a base surface area of the opening is smaller than the at least a portion of the top base surface area of the working electrode that is exposed to the electrolyte.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: October 20, 2020
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: John Foster, Morgan Mager
  • Patent number: 10788541
    Abstract: A method is proved for pinpointing a short-circuit in a wide-range air/fuel sensor having one or more sensor-terminals that include a reference-terminal, a pump-terminal, a return-terminal, and a tag-terminal. The method includes controlling a connection of a source of electric current to the one or more sensor-terminals; determining one or more status-values based on signals present at the sensor-terminals; and determining a sensor-status of the wide-range air/fuel sensor based on the connection of source of electric current and the one or more status-values.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: September 29, 2020
    Assignee: DELPHI TECHNOLOGIES IP LIMITED
    Inventors: Seyed R. Zarabadi, Daniel C. Penrod, Mark W. Gose
  • Patent number: 10770755
    Abstract: A surface-enabled, metal ion-exchanging battery device comprising a cathode, an anode, a porous separator, and a metal ion-containing electrolyte, wherein the metal ion is selected from aluminum (Al), gallium (Ga), indium (In), tin (Sn), lead (Pb), or bismuth (Bi), and at least one of the electrodes contains therein a metal ion source prior to the first charge or discharge cycle of the device and at least the cathode comprises a functional material or nanostructured material having a metal ion-capturing functional group or metal ion-storing surface in direct contact with the electrolyte. This energy storage device has a power density significantly higher than that of a lithium-ion battery and an energy density dramatically higher than that of a supercapacitor.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: September 8, 2020
    Assignee: Global Graphene Group, Inc.
    Inventors: Aruna Zhamu, Bor Z. Jang
  • Patent number: 10695718
    Abstract: A device (1) for generating clean air in a measuring apparatus, comprising: a duct (2) having an inlet and an outlet for the passage of an air flow to be cleaned; a platinum wire (3), positioned inside the duct (2), for intercepting the air flow to be cleaned, the platinum wire (3) is inserted in an electrical circuit (17) connectable to an electricity supply (15) to be operatively crossed by an electrical current.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: June 30, 2020
    Assignee: SACMI COOPERATIVA MECCANICI IMOLA SOCIETA' COOPERATIVA
    Inventor: Marco Remondini
  • Patent number: 10690647
    Abstract: A chemical sensor for heavy metal detection is provided. The chemical sensor includes an inlet, a chamber in fluid communication with the inlet, and an outlet in fluid communication with the chamber. A working electrode is provided in the chamber. The working electrode includes a plurality of protrusions extending into a fluid flow path in the chamber beyond a boundary layer of the fluid flow path. The chemical sensor also includes a reference electrode, a counter electrode, and a plurality of contact pads electrically connected to respective ones of the working electrode, the reference electrode and the counter electrode.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: June 23, 2020
    Assignees: NANYANG TECHNOLOGICAL UNIVERSITY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Nan Wang, Jianmin Miao, Michael S. Triantafyllou
  • Patent number: 10684266
    Abstract: A sensor can include a conductive region in electrical communication with at least two electrodes, the conductive region can include a complex, and the complex can include a carbon nanotube that is functionalized by a porphyrin.
    Type: Grant
    Filed: April 2, 2016
    Date of Patent: June 16, 2020
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Timothy M. Swager, Sophie Liu, Graham Thomas Sazama
  • Patent number: 10670550
    Abstract: In one illustrative embodiment, a test strip with a first planar substrate has coplanar electrodes on a first planar surface and a second planar substrate (which opposes the first surface of the first planar substrate) has coplanar electrodes on a second planar surface. The first planar surface of the first planar substrate having a first sensing area electrically connected to a first electrical contact. The second planar surface of the second planar substrate having a second electrical contact electrically connected to the first electrical contact via a conductive element, the conductive element extending between the first surface of the first planar substrate and the second surface of the second planar substrate without passing through the first planar substrate, the second planar substrate, or any intermediate layers.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: June 2, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Jennifer A. Samproni
  • Patent number: 10660555
    Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: May 26, 2020
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Jenn-Hann Larry Wang, Michael E. Miller, Raghavendhar Gautham, Yiwen Li, Rajiv Shah
  • Patent number: 10545113
    Abstract: Electrochemical detection method and related aspects Herein is disclosed an electrochemical test method comprising (i) comparing how a plurality of immittance functions and/or components thereof vary with a change in a parameter of interest for a first system, and then selecting an immittance function or component thereof for use in an electrochemical test; (ii) carrying out an electrochemical test step for a second system to determine at least one value for the immittance function or component thereof selected in step (i), and then, by using a quantitative relationship between the selected immittance function and the parameter of interest, determining a value in the parameter of interest. A computer program and apparatus are also disclosed herein.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: January 28, 2020
    Assignees: ISIS Innovation Limited, Universidade Estadual Paulista “Julio de Mequita Filho”
    Inventors: Jason Davis, Jr., Paulo Roberto Bueno
  • Patent number: 10520459
    Abstract: Methods, systems, and devices are disclosed for the identification of chemical agents and determination of their level of exposure using electrochemical detection and advanced signal processing. In one aspect, a method includes collecting a sample from a surface containing a chemical agent to an electrode on a sensor such that the chemical agent transfers on the electrode, detecting an electrochemical signal of the chemical agent on the electrode to transduce chemical information associated with the chemical agent to an electrical signal, processing the electrical signal to obtain electrochemical spectral signature data to identify the chemical agent and generating a series of coefficients of the electrochemical spectral signature data to reduce the data, and classifying the chemical information based on the series of coefficients among preselected data sets to determine a level of exposure to the chemical agent.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: December 31, 2019
    Assignee: The Regents of the University of California
    Inventors: Joseph Wang, Joshua Ray Windmiller, Aoife O'Mahony, Xavier Cetó, Manel Del Valle
  • Patent number: 10508359
    Abstract: The embodiments herein relate to methods and apparatus for determining whether a particular test bath is able to successfully fill a feature on a substrate. In various cases, the substrate is a semiconductor substrate and the feature is a through-silicon-via. Generally, two experiments are used: a first experiment simulates the conditions present in a field region of the substrate during the fill process, and the second experiment simulates the conditions present in a feature on the substrate during the fill process. The output from these experiments may be used with various techniques to predict whether the particular bath will result in an adequately filled feature.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: December 17, 2019
    Assignee: Lam Research Corporation
    Inventors: Lee Brogan, Steven T. Mayer, Matthew Thorum, Joseph Richardson, David W. Porter, Haiying Fu
  • Patent number: 10451581
    Abstract: A system for detecting an analyte gas including a system housing having an inlet system, an electrochemical gas sensor within the housing and in fluid connection with the inlet system, the electrochemical sensor including a working electrode responsive to the analyte gas, and a control system in electrical connection with the working electrode. The control system is operative to bias the working electrode at a first potential at which the electrochemical gas sensor is responsive to the analyte gas and operative to bias the working electrode at a second potential, different from the first potential, at which the electrochemical gas sensor is sensitive to a driving force created in the vicinity of the inlet system to test at least one transport path of the system.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: October 22, 2019
    Assignee: MSA TECHNOLOGY, LLC
    Inventors: Towner Bennett Scheffler, Michael Alvin Brown
  • Patent number: 10448833
    Abstract: The present disclosure relates to systems and methods for activating a circuit of an implant device. Consistent with one implementation, an implant device is provided with a sensor including a working electrode (WE) and a counter electrode (CE). The sensor may be configured to generate a first current at the CE when the implant device is implanted in a body of a subject. A sensing circuit may also be provided that is electrically coupled to the WE of the sensor. The sensing circuit may be activated based on the first current and utilize the sensor to measure one or more parameters of an individual or other subject.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: October 22, 2019
    Assignee: VERILY LIFE SCIENCES LLC
    Inventors: Alireza Dastgheib, Johan Vanderhaegen
  • Patent number: 10444178
    Abstract: A sensor system including devices and methods for determining the concentration of an analyte in a sample is described. Input signals including amperometric and voltammetric duty cycles of excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed system may reduce analysis errors, thus improving measurement performance, by adjusting the potential and/or scan rate in response to output currents obtained from voltammetric scans. The disclosed system also may determine the concentration of more than one ionizable species in the sample by adjusting the potential and/or scan rate in response to output currents obtained from voltammetric scans. The multiple, determined concentrations may be used to determine the concentration of multiple analytes or to correct the concentration determined for an analyte, thus improving the measurement performance of the system.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: October 15, 2019
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventor: Huan-Ping Wu
  • Patent number: 10436739
    Abstract: A unique solution to measure NOx emissions is achieved less expensively and with much greater sensitivity than commercially available NOx sensors. A sensor's active materials are modified and operational algorithms are used to concurrently measure single ppm levels of NOx and NH3 with response times of one second or less. A combined NOx/NH3 sensor to have much finer control of an SCR system, thereby reducing NOx emissions and ammonia slip in a closed-loop device, all at lower cost than the current state-of-the-art solutions.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: October 8, 2019
    Assignee: BJR Sensors LLC
    Inventor: Boris Farber
  • Patent number: 10429250
    Abstract: Disclosed herein are methods and systems for conserving energy of a power source of an analyte monitoring device. Also disclosed herein are methods and systems for reducing noise during data transmissions to and from the analyte monitoring device.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: October 1, 2019
    Assignee: Abbott Diabetes Care, Inc.
    Inventors: Saeed Nekoomaram, Martin J. Fennell, Mark Kent Sloan, Lei He, Jeffery Mario Sicurello