For Nitrogen Or Nitrogen Containing Compound Patents (Class 205/780.5)
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Patent number: 11913822Abstract: Methods and systems for detecting membrane blockage in a gas detector are disclosed. In some embodiments, the gas detector comprises a membrane defining a sensing chamber of the detector, the sensing chamber comprising a relaxed state pressure. The method comprises applying one or more forces on one or more walls of the membrane, wherein applying the force causes a volume change inside the sensing chamber. The method further comprises measuring a pressure change inside the sensing chamber, the pressure change being caused by the volume change. The method further comprises determining a rate of return to the relaxed state inside the chamber and determining a condition of the membrane based on the determined rate of return to the relaxed state.Type: GrantFiled: August 30, 2022Date of Patent: February 27, 2024Inventors: Tanner Warner, Jon K. Evju
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Analyte detection using electrochemical impedance spectroscopy-based imaginary impedance measurement
Patent number: 11549904Abstract: Methods for detecting one or more analytes in a sample utilizing Electrochemical Impedance Spectroscopy (EIS) measurement. In one method, analyte detection includes comparing an imaginary impedance measurement to a calibration curve of concentrations for each target analyte. The calibration curve of concentrations for each target analyte is established at an optimal frequency. In another method, a signal decoupling algorithm is utilized for detection of more than one analyte on an electrode.Type: GrantFiled: March 20, 2018Date of Patent: January 10, 2023Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: David Probst, Chi Lin, Marcus Smith, Jeffrey LaBelle -
Patent number: 11493909Abstract: A semiconductor fabrication facility (FAB) is provided. The FAB includes a number of processing tools. The FAB also includes a sampling station connected to the processing tools. In addition, the FAB includes a detection vehicle detachably connected to the sampling station and comprising a metrology module. When the detection vehicle is connected to the sampling station, a gas sample is delivered from one of the processing tools to the metrology module of the detection vehicle via the sampling station for performing a measurement of a parameter in related to the gas sample by the metrology module. In addition, the FAB includes a control system configured to issue a warning when the parameter in related to the gas sample from the one of the processing tools is out of a range of acceptable values associated with the one of the processing tools.Type: GrantFiled: April 16, 2021Date of Patent: November 8, 2022Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY LTD.Inventors: Lee-Chun Chen, Yi-Chien Yang, Chia-Lin Hsu
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Patent number: 11166653Abstract: Some embodiments relate to a reconfigurable biosensor adapted for performing tests in a plurality of modes or a smartphone or wearable device comprising the reconfigurable biosensor.Type: GrantFiled: October 12, 2016Date of Patent: November 9, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Drew Hall, Alexander Chuan Sun
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Patent number: 10969362Abstract: A particular-gas concentration-measuring apparatus measures a particular gas concentration being the concentration of a particular gas in a measurement-object gas. The particular-gas concentration-measuring apparatus comprises a particular-gas concentration derivation unit. The particular-gas concentration derivation unit causes an electromotive-force acquisition unit to acquire an electromotive force and derives a correction value compensating for the difference between a correction-value derivation electromotive force that is the electromotive force and the reference electromotive force at a correction-value derivation time. The correction-value derivation time is a time during which a sensing electrode is exposed to a correction-value derivation gas, the correction-value derivation gas being the measurement-object gas where neither ammonia nor a combustible gas is assumed to be included.Type: GrantFiled: January 31, 2019Date of Patent: April 6, 2021Assignee: NGK INSULATORS, LTD.Inventor: Taku Okamoto
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Patent number: 10738673Abstract: Provided is an electrically heated catalytic converter including at least a conductive substrate and an electrode member that is fixed to the substrate, in which a protective film is formed on a surface of at least a portion of the electrode member. In the electrically heated catalytic converter, at least a portion of the protective film is formed of Al2O3, SiO2, a composite material of Al2O3 and SiO2, or a composite oxide including Al2O3, SiO2, or a composite material of Al2O3 and SiO2 as a major component, the protective film has an amorphous structure or a partially crystalline glass structure having a crystallization rate of 30 vol % or lower with respect to the entire portion of the protective film, and a thickness of the protective film is in a range of 100 nm to 2 ?m.Type: GrantFiled: April 27, 2017Date of Patent: August 11, 2020Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, NGK INSULATORS, LTD.Inventors: Rentaro Mori, Yoshiyuki Kasai, Yoshimasa Omiya
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Patent number: 10641730Abstract: An oxidation-reduction substance equilibrium potential estimating method is provided, the method including: applying a voltage to an electrode contacting a sample containing an oxidation-reduction substance and sweeping the voltage; measuring a current flowing through the electrode; if an integrated value of the current becomes a value within a reference range, determining whether to sweep the voltage in an opposite direction to a sweep direction in the previous sweeping or to terminate sweeping of the voltage; if it is determined to terminate sweeping of the voltage, estimating an oxidation-reduction substance equilibrium potential at a value of the voltage; and if it is determined to sweep the voltage, sweeping the voltage in an opposite direction to a sweep direction in the previous sweeping.Type: GrantFiled: May 12, 2017Date of Patent: May 5, 2020Assignee: ASAHI KASEI KABUSHIKI KAISHAInventors: Masaaki Ayabe, Ken Udagawa
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Patent number: 10539493Abstract: The particulate matter detection sensor includes a conductive part, and the pair of electrodes that are arranged at specified spacing so as to face each other. The conductive part is formed into a plate shape using a conductive material having electrical resistivity that is higher than particulate matter. One major surface of the conductive part functions as an accumulation surface on which particulate matter accumulates. The pair of electrodes are formed on this accumulation surface.Type: GrantFiled: July 24, 2017Date of Patent: January 21, 2020Assignee: DENSO CORPORATIONInventors: Hironobu Shimokawa, Kazuhiko Koike, Masahiro Yamamoto, Go Miyagawa
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Patent number: 10429338Abstract: A gas sensor in which an electrode is prevented from being poisoned is provided. A mixed-potential type gas sensor includes a sensor element composed a solid electrolyte. The sensor element includes: a measurement gas introduction space having an open end at a distal end and extending in a longitudinal direction; a sensing electrode provided on an inner side of the measurement gas introduction space; and a heater configured to heat the sensor element. The concentration of the gas component is determined based on a potential difference between the sensing electrode and a reference electrode, while the heater heats the sensor element so that a place having a temperature higher than the temperature of the sensing electrode and the melting point of a poisoning substance exists between the open end and the sensing electrode and the temperature decreases toward the sensing electrode.Type: GrantFiled: August 25, 2017Date of Patent: October 1, 2019Assignee: NGK Insulators, Ltd.Inventors: Taku Okamoto, Noriko Hirata, Yuki Nakayama, Kosuke Monna
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Patent number: 10390162Abstract: The method can include depositing a graphene oxide containing material from solution to form a laminar nano-structure of graphene oxide paper, and assembling at least a portion of the graphene oxide paper as a diaphragm of the acoustic transducer. The acoustic transducer can be a magnetic induction based microphone, a diaphragm loudspeaker, or a magnetic induction based loudspeaker, for instance.Type: GrantFiled: October 6, 2015Date of Patent: August 20, 2019Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITYInventors: Peter Gaskell, Robert-Eric Gaskell, Thomas Szkopek, Jung Wook Hong
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Patent number: 9346783Abstract: A method of producing an oxidized compound is disclosed. An electric potential is measured of an oxidation reaction solution for producing an oxidized compound by an oxidation reaction, and an end point is determined of the oxidation reaction on the basis of a predefined decrease of the electric potential. Preferably, after the electric potential of the oxidation reaction solution is reached to a highest electric potential, a point is determined where the amount of an electric potential dropped from the highest electric potential reaches the predefined amount of an electric potential as the end point of the oxidation reaction. The method also may introduce an oxidation reaction terminating agent to the oxidation reaction solution immediately after determining the end point of the oxidation reaction.Type: GrantFiled: October 31, 2013Date of Patent: May 24, 2016Assignee: Takeda Pharmaceutical Company LimitedInventors: Masayoshi Kaneko, Shigeo Yabuno, Kenji Iwaoka, Hidetoshi Nishimura
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Patent number: 9255904Abstract: A sensor device for sensing at least a proportion of at least one gas component of a gas in a measurement gas space, in particular for detecting oxygen in an exhaust gas of a combustion machine, is proposed. The sensor device includes at least one sensor element. The sensor element includes at least one first electrode and at least one first reference electrode and at least one second reference electrode. The second reference electrode is connected to at least one reference gas channel. The first electrode is connected to the first reference electrode and the second reference electrode by at least one respective solid electrolyte. The sensor element has at least one diffusion element between the first reference electrode and the reference gas channel.Type: GrantFiled: October 17, 2012Date of Patent: February 9, 2016Assignee: ROBERT BOSCH GMBHInventors: Peer Kruse, Jens Schneider, Lothar Diehl, Gerhard Schneider, Christoph Peters
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Patent number: 9194900Abstract: An electrode evaluation apparatus for evaluating a characteristic of an electrode based on an electrochemical property includes a potential control unit, an impedance acquiring unit, a current value acquiring unit, and a normalized impedance calculation unit. The potential control unit is configured to control a potential applied to an electrode. The impedance acquiring unit is configured to acquire an impedance characteristic of the electrode under a specific DC operating condition provided by the potential control unit. The current value acquiring unit is configured to acquire a temporal change in direct current value under the specific DC operating condition. The normalized impedance calculation unit is configured to apply the temporal change in direct current value acquired by the current value acquiring unit to calculate a normalized impedance where impedance acquired by the impedance acquiring unit is multiplied by the direct current value.Type: GrantFiled: February 6, 2013Date of Patent: November 24, 2015Assignee: YOKOGAWA ELECTRIC CORPORATIONInventors: Souichirou Torai, Daisuke Yamazaki, Nobuhiro Tomosada, Tomomi Akutsu, Makoto Kawano, Tetsuo Yano
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Patent number: 9188525Abstract: A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component.Type: GrantFiled: February 13, 2015Date of Patent: November 17, 2015Assignee: AGAMATRIX, INC.Inventors: Sridhar G. Iyengar, Ian S. Harding
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Patent number: 9075004Abstract: Devices and methods are provided for determining the concentration of a reduced form of a redox species. For example, a device can include a working electrode and a counter electrode spaced by a predetermined distance so that reaction produces from the counter electrode arrive at the working electrode. An electric potential difference can be applied between the electrodes, and the potential of the working electrode can be selected such that the rate of electro-oxidation of the reduced form of the species is diffusion controlled. Current as a function of time can be determined, the magnitude of the steady state current can be estimated, and a value indicative of the diffusion coefficient and/or of the concentration of the reduced form of the species can be obtained from the change in current with time and the magnitude of the steady state current. Other embodiments of apparatuses, devices, and methods are also provided.Type: GrantFiled: December 2, 2013Date of Patent: July 7, 2015Assignee: LifeScan, Inc.Inventors: Alastair McIndoe Hodges, Thomas William Beck, Oddvar Johansen
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Publication number: 20150148257Abstract: Provided is a method for detecting analyte in a sample, which method comprises: (a) contacting the sample with a peptide nucleic acid (PNA) probe; (b) performing an electrochemical impedance spectrometry (EIS) measurement on the sample; (c) determining the presence, absence, quantity and/or identity of the analyte from the EIS measurement; wherein the analyte comprises nucleic acid; and wherein the quantity of analyte in the sample when the sample is taken is substantially the same as the quantity of analyte in the sample when the sample is subjected to the EIS measurement.Type: ApplicationFiled: November 21, 2012Publication date: May 28, 2015Inventors: Holger Schulze, Damion Corrigan, Till Bachmann
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Patent number: 9034169Abstract: The method for detection of cyanide in water is a method for the detection of a highly toxic pollutant, cyanide, in water using ZnO2 nanoparticles synthesized locally by an elegant Pulsed Laser Ablation technique. ZnO2 nanoparticles having a median size of 4 nm are synthesized from pure zinc metal target under UV laser irradiation in a 1-10% H2O2 environment in deionized water. The synthesized ZnO2 nanoparticles are suspended in dimethyl formamide in the presence of Nafion, and then ultrasonicated to create a homogenous suspension, which is used to prepare a thin film of ZnO2 nanoparticles on a metal electrode. The electrode is used for cyanide detection.Type: GrantFiled: March 14, 2013Date of Patent: May 19, 2015Assignee: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALSInventors: Mohammed Ashraf Gondal, Qasem Ahmed Qasem Drmosh, Z. H. Yamani, Tawfik Abdo Saleh
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Patent number: 9028670Abstract: The present invention relates to a method for proportioning nitrate and/or nitrite ions in a solution using a copper electrode, said method being characterized in that it is carried out in constant potential mode and moreover in that it includes the steps of: i. applying a first potential to the copper electrode so as to reduce the copper oxides present on the surface of the metal copper electrode; ii. applying a second potential to the copper electrode so as to oxidize the metal copper formed in Step i into cupric ions; iii. applying a third potential to the copper electrode so as to reduce the copper oxides possibly formed in Step ii. Steps i through iii being carried out in a support electrolyte; and iv.Type: GrantFiled: November 17, 2010Date of Patent: May 12, 2015Assignee: Centre National de la Recherche ScientifiqueInventors: Catherine Debiemme, Hubert Cachet, Thi Tuyet Maï{umlaut over ( )} Trong Long, Nizar Aouina
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Publication number: 20150122669Abstract: The application relates to an electrode for use in the electrochemical detection of a target species, wherein the electrode has a planar surface disposed on which are probe molecules that are capable of binding selectively to the target species, wherein the electrode, prior to binding of the probe molecules with the target species, has an electron transfer resistance per area of the electrode of from 10 megaohms cm?2 to 95 megaohms cm?2.Type: ApplicationFiled: May 1, 2013Publication date: May 7, 2015Inventors: Jason Davis, Paulo Roberto Bueno
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Patent number: 8945370Abstract: An electrochemical method for capsaicinoid and/or related compound detection in a sample by way of a screen printed electrode having a working electrode, a reference electrode, and a counter electrode. The working electrode can be screen-printed using conductive carbon ink; the reference electrode can be screen printed using conductive carbon ink; and the counter electrode can be screen printed using silver/silver chloride. The method includes contacting the electrode with the sample in the presence of electrolyte solution, and determining whether a change in redox potential occurs by way of differential pulse voltammetry, wherein a modulation amplitude is between approximately 0.1 volt/min and approximately 2.0 volt/min, a step potential is between approximately 0.0005 volt and approximately 0.01 volt, a modulation time is 0.05 seconds, and a corresponding interval time is approximately 0.5 second.Type: GrantFiled: March 30, 2012Date of Patent: February 3, 2015Assignee: Agricultural Research Development AgencyInventors: Werasak Surareungchai, Chatuporn Phanthong
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Publication number: 20150027906Abstract: An ammonia sensor that includes an ionic liquid impregnated sensing electrode (anode) and a cathode separated by a membrane. During operation, in the presence of ammonia, the anode and cathode generate current manifesting the electrochemical reaction of ammonia in the sensing electrode. Ionic liquids distributed in the ionomer film in the gas diffusion electrodes ensure the reactivity under wide range of environment conditions while maintaining the ability of the device to quantify ammonia concentration in the environment. The sensor can therefore sustain long time operation without internal humidification due to the non-volatility of the ionic liquids.Type: ApplicationFiled: July 24, 2013Publication date: January 29, 2015Applicant: Hamilton Sundstrand CorporationInventors: Lei Chen, Hsien-chi W. Niu, Joseph V. Mantese
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Publication number: 20150021203Abstract: The disclosed invention relates to an amperometric gas sensor for measuring the concentration of an analyte, comprising: a solid support; and a working electrode in contact with the solid support; wherein the analyte comprises a dopant which when in contact with the solid support increases the electrical conductivity of the solid support. A sterilization process employing the amperometric gas sensor is disclosed.Type: ApplicationFiled: September 30, 2014Publication date: January 22, 2015Inventors: Elizabeth H. Schenk, Peter A. Burke, Michael A. Centanni
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Publication number: 20150021204Abstract: The disclosed invention relates to an amperometric gas sensor for measuring the concentration of an analyte, comprising: a solid support; and a working electrode in contact with the solid support; wherein the analyte comprises a dopant which when in contact with the solid support increases the electrical conductivity of the solid support. A sterilization process employing the amperometric gas sensor is disclosed.Type: ApplicationFiled: September 30, 2014Publication date: January 22, 2015Inventors: Elizabeth H. Schenk, Peter A. Burke, Michael A. Centanni
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Publication number: 20150001099Abstract: A nanodevice includes a nanochannel disposed through a dielectric material. A first electrode is disposed on a first side of the nanochannel, is formed within the dielectric material and has a surface exposed within the nanochannel. A second electrode is disposed on a second side of the nanochannel, is formed within the dielectric material and has a surface exposed within the nanochannel opposite the first electrode. A power circuit is connected between the first and second electrodes to create a potential difference between the first and second electrodes such that portions of a molecule can be identified by a change in electrical properties across the first and second electrodes as the molecule passes.Type: ApplicationFiled: August 15, 2013Publication date: January 1, 2015Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Jingwei Bai, Niina S. Haiminen, Laxmi P. Parida, Gustavo A. Stolovitzky
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Publication number: 20140346060Abstract: A method to detect beta-lactoglobulin (BLG) is described. The method includes the steps of adding a known concentration of hydrogen peroxide to a sample known to, or suspected of containing BLG; and electrolyzing the sample using a working electrode at a fixed potential sufficient to electrolyze BLG, and measuring a current signal within the sample. A diminution of the current signal in the sample as compared to a corresponding current signal from a standard solution containing a known concentration of hydrogen peroxide and no BLG indicates that the sample contains BLG.Type: ApplicationFiled: August 7, 2014Publication date: November 27, 2014Inventors: Sundaram Gunasekaran, Jiang Yang
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Publication number: 20140349005Abstract: Disclosed herein are biosensor systems and related methods for detecting analytes in aqueous and biologic environments. A biosensor system for detecting binding of an analyte of interest may include a detector configured to detect a change in an electrical property on a surface thereof. The detector may be a FET. The system also may include a passive layer disposed on a top surface of the detector. Further, the system may include a hydrophobic layer disposed on the passive layer. The system also may include a receptor-attachment material configured for binding to an analyte. A receptor may bind to the analyte, and the receptor may be attached to the receptor-attachment material. The binding of the analyte to the receptor can cause the change of the electrical property at the surface. In response to the change for example, a current may change for indicating the binding of the analyte to the receptor.Type: ApplicationFiled: December 3, 2012Publication date: November 27, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Allen Dale Everett, Howard Katz, Kalpana Besar, Weiguo Huang
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Publication number: 20140346059Abstract: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.Type: ApplicationFiled: June 10, 2014Publication date: November 27, 2014Inventors: Mark A. Akeson, David W. Deamer, William B. Dunbar, Roger Jinteh Arrigo Chen, Noah A. Wilson
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Publication number: 20140342359Abstract: Contemplated methods and devices comprise use of a charged probe and a neutralizer in the electrochemical detection of a wide range of analytes, including nucleic acids, proteins, and small molecules. In certain embodiments the neutralizer forms a complex with the probe that has a reduced charge magnitude compared to the probe itself, and is displaced from the probe when the complex is exposed to the analyte.Type: ApplicationFiled: November 21, 2012Publication date: November 20, 2014Inventors: Shana O. Kelley, Alexandre Zaragoza, Edward Hartley Sargent, Jagotamoy Das, Kristin Cederquist
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Patent number: 8882988Abstract: The potentiometric device and method selective for pioglitazone relates to the detection of pioglitazone in urine, in other liquid biological samples, and in pharmaceutical preparations for quality control testing and the like, and particularly to the use of a potentiometric sensor for potentiometric detection and measurement of the concentration of pioglitazone. The potentiometric sensor includes a plasticized polyvinyl chloride (PVC) matrix membrane having an ionophore impregnated or embedded therein. The ionophore is an iodobismuth anion in which the iodobismuth anion forms a complex with pioglitazone. The polymer membrane is plasticized with either ortho-nitrophenyl octyl ether (NPOE) or dioctyl phthalate (DOP).Type: GrantFiled: December 26, 2012Date of Patent: November 11, 2014Assignee: UMM Al-Qura UniversityInventor: Amr Lotfy Saber Hefny
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Publication number: 20140284222Abstract: Described herein is a gas meter system (5) for detecting toxic gas combinations including a housing (10) having an opening (20), a measuring cell (15) enclosed by the housing and comprising a plurality of gas sensors (17) in fluid communication with the environment via the opening in the housing, and an evaluating circuit (32). The gas sensors detects a concentration of a first gas and a concentration of a second gas so the evaluating circuit can identify a hazard due to an additive or synergistic toxic effect upon combined exposure to the first gas and the second gas. Related apparatus, systems, methods and/or articles are described.Type: ApplicationFiled: November 1, 2011Publication date: September 25, 2014Applicant: Draeger Safety, Inc.Inventors: Richard William Wanek, JR., Greg Martin Sesny
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Publication number: 20140262832Abstract: A method to detect beta-lactoglobulin (BLG) is described. The method includes the steps of adding a known concentration of hydrogen peroxide to a sample known to, or suspected of containing BLG; and electrolyzing the sample using a working electrode at a fixed potential sufficient to electrolyze BLG, and measuring a current signal within the sample. A diminution of the current signal in the sample as compared to a corresponding current signal from a standard solution containing a known concentration of hydrogen peroxide and no BLG indicates that the sample contains BLG.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: Wisconsin Alumni Research FoundationInventors: Sundaram Gunasekaran, Jiang Yang
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Publication number: 20140251831Abstract: Detecting a leak from a site in a sealed system with a source of pressurized gas which is capable of passing through the site, a composition of matter which adheres to the surfaces of the system and which is capable of showing the presence of the gas escaping from the site. The method includes: injecting gas into the system to a pressure in excess of the surrounding pressure, and covering the external surface with the composition to identify the location of the site by the interaction of the escaping gas with the composition. The composition is foam that includes a surfactant which forms a least one bubble in the presence of escaping gas and an indicator which changes color in the presence of the escaping gas. The leak is an opening down to at least the size of a hole 0.001? in diameter. A gas detector may also be used.Type: ApplicationFiled: March 7, 2013Publication date: September 11, 2014Inventors: Kenneth D. Ley, Neal R. Pederson, Steven G. Thoma, Bernie C. Thompson
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Publication number: 20140251832Abstract: An electrochemical assay uses paramagnetic particles (10) including a coating of electroactive material (12) in order to detect or measure an analyte (30) of interest. The analyte is brought within the vicinity of an electrode (42) along with the coated paramagnetic particles (10). Application of a potential converts the electroactive coating (12) on the paramagnetic particles (10) into ions that can be measured using, for example, anodic stripping voltammetry. The level of ions corresponds to the amount of analyte of interest in the sample.Type: ApplicationFiled: October 22, 2012Publication date: September 11, 2014Inventor: Robert Andrew Porter
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Publication number: 20140224673Abstract: The disclosure relates to the use of nanoparticles that are coated with unique oligonucleotide (e.g., DNA) sequences of various base lengths (“nano-DNA”) that act as barcodes for product authentication, product serialization, brand protection, track-and-trace, intelligent supply chain, and law enforcement. The nano-DNA can be incorporated into inks, dyes, resins, labels, and other markings at all manufacturing levels, including the product (unit) level, to encode company and product-specific information. The nano-DNA can also be embedded in the product itself during the manufacturing process. Furthermore, the nano-DNA can be quickly, simply, and inexpensively monitored and verified using an electrochemical biosensor device in resource-limited field conditions.Type: ApplicationFiled: February 6, 2014Publication date: August 14, 2014Applicant: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITYInventor: Evangelyn C. Alocilja
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Publication number: 20140216950Abstract: The invention discloses an erythropoietin receptor modified electrode, which is a glassy carbon electrode with erythropoietin receptor as recognition element fixed onto the electrode surface via ZnO sol-gel. The modified electrode can be prepared easily, and its performance is stable. After 50-day storage in the dark at 4° C., its response current remained approximately 77% of the original value. An electrochemical biosensor using this modified electrode as working electrode, a platinum electrode as counter electrode, a saturated calomel electrode as reference electrode, and 2 mmol/L K3[Fe(CN)6]-K4[Fe(CN)6] phosphate buffer as the test base solution, can detect erythropoietin (EPO) and/or recombinant human erythropoietin (rhEPO) in a fast, specific, and sensitive manner, with a linear range of 5 pg/L-500 ng/L and a limit of detection of 0.5 pg/L. In particular, according to peak potential differences, the biosensor allows accurate discrimination of EPO and rhEPO.Type: ApplicationFiled: October 9, 2012Publication date: August 7, 2014Applicant: First Affiliated Hospital, Third Military Medical University, Chinese People's Liberation Army, P.R.Inventors: Liqun Zhang, Yunxia Wang, Weiling Fu
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Publication number: 20140174952Abstract: The potentiometric device and method selective for pioglitazone relates to the detection of pioglitazone in urine, in other liquid biological samples, and in pharmaceutical preparations for quality control testing and the like, and particularly to the use of a potentiometric sensor for potentiometric detection and measurement of the concentration of pioglitazone. The potentiometric sensor includes a plasticized polyvinyl chloride (PVC) matrix membrane having an ionophore impregnated or embedded therein. The ionophore is an iodobismuth anion in which the iodobismuth anion forms a complex with pioglitazone. The polymer membrane is plasticized with either ortho-nitrophenyl octyl ether (NPOE) or dioctyl phthalate (DOP).Type: ApplicationFiled: December 26, 2012Publication date: June 26, 2014Applicant: UMM AL-QURA UNIVERSITYInventor: AMR LOTFY SABER HEFNY
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Patent number: 8753494Abstract: The present disclosure relates to a gas sensor including a nanopore electrode and a fluorine compound coated on the nanopore electrode, and also relates to a preparing method of the gas sensor.Type: GrantFiled: August 16, 2012Date of Patent: June 17, 2014Assignee: Ewha University—Industry Collaboration FoundationInventors: Youngmi Lee, Myung Hwa Kim, Min-Cheol Oh, Hyunkyung Do, Kyung Jang, Ji-Hyang Jang
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Publication number: 20140154811Abstract: Technologies are generally described for gas filtration and detection devices. Example devices may include a graphene membrane and a sensing device. The graphene membrane may be perforated with a plurality of discrete pores having a size-selective to enable one or more molecules to pass through the pores. A sensing device may be attached to a supporting permeable substrate and coupled with the graphene membrane. A fluid mixture including two or more molecules may be exposed to the graphene membrane. Molecules having a smaller diameter than the discrete pores may be directed through the graphene pores, and may be detected by the sensing device. Molecules having a larger size than the discrete pores may be prevented from crossing the graphene membrane. The sensing device may be configured to identify a presence of a selected molecule within the mixture without interference from contaminating factors.Type: ApplicationFiled: November 30, 2012Publication date: June 5, 2014Inventors: Angele Sjong, Kraig Anderson, Gary L. Duerksen, Seth Adrian Miller
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Publication number: 20140124383Abstract: An electrode chip for detecting a biomolecule includes a substrate; and an electrode that includes an electrode substrate, at least one of a metallic salt or a metallic oxide provided on an outermost surface on an opposite side of the electrode substrate from a side provided with the substrate, and a biomolecular probe-immobilizing material which is provided on the outermost surface and to which a biomolecular probe is fixed.Type: ApplicationFiled: April 20, 2012Publication date: May 8, 2014Inventors: Yuji Miyahara, Akira Matsumoto, Tatsuro Goda, Yasuhiro Maeda, Chiho Kataoka
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Publication number: 20140128589Abstract: The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion. includes an electrode system, and the nucleic acid molecule to be evaluated is arranged on the base is used. In the present invention, it is preferred that a plurality of kinds of nucleic acid molecule to be evaluated is arranged on the base, and the plurality of kinds of nucleic acid molecules to be evaluated is evaluated by a single device.Type: ApplicationFiled: July 2, 2012Publication date: May 8, 2014Inventors: Naoto Kaneko, Katsunori Horii, Jou Akitomi, Shintarou Katou, Iwao Waga
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Publication number: 20140116892Abstract: Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined.Type: ApplicationFiled: March 26, 2013Publication date: May 1, 2014Applicant: TECHNISCHE UNIVERSITÄT MÜNCHENInventor: TECHNISCHE UNIVERSITÄT MÜNCHEN
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Patent number: 8712701Abstract: Provided is a potentiometric sensor chip in which the positional relationship among a reference electrode, a measurement electrode, and a sample inlet which enables measurement from the start of a reaction is defined, and further provided is a method for detecting the start time of the reaction. A very small amount of sample is measured with high accuracy. The very small quantity of sample is measured by a rate assay. When a reference electrode (103) is disposed between a sample inlet (102) and a measurement electrode (104), a sample solution arrives at the reference electrode (103) earlier than at the measurement electrode (104), whereby the surface potential of the measurement electrode (104) can be measured simultaneously when the sample solution arrives at the measurement electrode (104) and dissolves a reagent and thereby a reaction starts.Type: GrantFiled: October 29, 2009Date of Patent: April 29, 2014Assignee: Hitachi, Ltd.Inventors: Yu Ishige, Masao Kamahori, Kuniaki Nagamine
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Publication number: 20140102915Abstract: The present disclosure includes an electrochemical proximity assay (ECPA) which leverages two aptamer or antibody-oligonucleotide probes and proximity-dependent DNA hybridization to move a redox active molecule near an electrically conductive base. The ECPA of the present disclosure produces rapid, quantitative results, enabling point-of-care use in the detection of biomarkers of disease.Type: ApplicationFiled: October 12, 2012Publication date: April 17, 2014Applicant: AUBURN UNIVERSITYInventors: Jiaming Hu, Tanyu Wang, Christopher J. Easley, Curtis G. Shannon
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Publication number: 20140102916Abstract: Described is an electrochemical flow cell (1) for analyzing fluid samples including a first member (100) including a first working surface (101), the first working surface (101) including a sample outlet (102), and a second member (200) including a second working surface (201), the second working surface (201) including a working electrode (202). The first and second member (100, 200) being connectable to each other to create a chamber (2) in between the first (101) and second working surface (201). The first working surface (101) being opposite and spaced apart from the second working surface (201) and the sample outlet (102) being directed at the working electrode (202). The electrochemical flow cell (1) includes an adjustment element for stepless adjustment of a distance (d) between the first working surface (101) and the second working surface (201).Type: ApplicationFiled: October 12, 2012Publication date: April 17, 2014Applicant: Antec Leyden B.V.Inventors: Herman Robert LOUW, Hendrik-Jan Brouwer, Nicolaas Reinhoud
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Publication number: 20140093897Abstract: The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport and electrical conductance.Type: ApplicationFiled: March 22, 2012Publication date: April 3, 2014Applicants: Stealth Peptides International, Inc., Cornell UniversityInventors: Hazel H. Szeto, Alexander V. Birk, D. Travis Wilson
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Publication number: 20140083866Abstract: Described herein is a device comprising: a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a fluid and having a capacitance; first circuitry configured to controllably set the plurality of first reaction electrode to a predetermined voltage and allow the capacitance of the plurality of first reaction electrode to charge or discharge through the fluid; and second circuitry configured to measure a rate of charging or discharging of the capacitance of the plurality of first reaction electrodes. Also described herein is a method of using this device to sequence DNA.Type: ApplicationFiled: March 15, 2013Publication date: March 27, 2014Inventors: Jonathan S. DANIELS, Oguz H. ELIBOL, Grace M. CREDO, Xing SU
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Publication number: 20140069823Abstract: A disposable urea sensor has a laminated body having a fluid sample inlet end and an electrical contact end, a fluid sample inlet, a substantially flat sample chamber in communication between the fluid sample inlet and a vent opening, the sample chamber being adapted to collect a fluid sample through the fluid sample inlet, a working electrode and a reference electrode within the sample chamber, and a reagent matrix disposed on the working electrode wherein the reagent matrix contains urease.Type: ApplicationFiled: November 12, 2013Publication date: March 13, 2014Applicant: NOVA BIOMEDICAL CORPORATIONInventors: Handani Winarta, Jianhong Pei, Mary Lauro, Chung Chang Young, Xiaohua Cai
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Patent number: 8663452Abstract: A method using an electrolytic cell to electrolyze urea to produce at least one of H2 and NH3 is described. An electrolytic cell having a cathode with a first conducting component, an anode with a second conducting component, urea and an alkaline electrolyte composition in electrical communication with the anode and the cathode is used to electrolyze urea. The alkaline electrolyte composition has a hydroxide concentration of at least 0.01 M.Type: GrantFiled: October 12, 2012Date of Patent: March 4, 2014Assignee: Ohio UniversityInventor: Gerardine G. Botte
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Publication number: 20140051080Abstract: Compounds of general formula I are used as labels in an electrochemical assay: (I) in which: Fc and Fc? are substituted or unsubstituted ferrocenyl moieties, X is a C1 to C6 alkylene chain which is optionally interrupted by —O— or —NH—; Y is a C1 to C6 alkylene chain which is optionally interrupted by —O— or —NH—; Z is a C1 to C12 alkylene chain which may optionally be substituted and/or may optionally be interrupted by —O—, —S—, cycloalkyl, —CO—, —CON R1—, —NR1CO— or —NR1— in which R1 represents hydrogen or C1 to C4 alkyl; and R is a linker group. Compounds I are used to make labelled substrates, as well as functionalised compounds for making the labelled substrates.Type: ApplicationFiled: December 22, 2011Publication date: February 20, 2014Inventors: Jonathan Sharp, Stephen Flower, Christopher Frost
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Publication number: 20140021067Abstract: An electrochemical sensor for sensing a gaseous analyte includes a substrate having at least two electrodes disposed thereon, and a carbon nanotube-polyaniline (CNT/PANI) film disposed on the substrate and in contact with at least two electrodes. The CNT/PANI film includes carbon nanotubes coated with a thin layer of polyaniline. The thickness of the polyaniline coating is such that electron transport can occur along and/or between the carbon nanotubes.Type: ApplicationFiled: September 19, 2013Publication date: January 23, 2014Applicant: The Research Foundation for The State University of New YorkInventor: Vladimir Samuilov